Ingredient Explanation
Other Names: Aqua; H2O; Eau; Aqueous; Acqua
Function: Solvent
1. Definition Water:
Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.
2. Use:
Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.
3. Usage Water:
When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.
4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.
- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.
Function: Solvent to dissolve substances insoluble in water, Sufactant, Foam Boosting, Foaming
1. Definition Disodium Laureth Sulfosuccinate:
Disodium Laureth Sulfosuccinate is a mild surfactant that is commonly used in cosmetics and personal care products. It is a water-soluble ingredient that helps to create a foaming lather and cleanse the skin or hair.
2. Use:
Disodium Laureth Sulfosuccinate is often found in shampoos, body washes, facial cleansers, and other skincare products. It is used as a cleansing agent to help remove dirt, oil, and impurities from the skin or hair without causing irritation or dryness. Due to its mild nature, it is suitable for sensitive skin types.
3. Usage Disodium Laureth Sulfosuccinate:
When using products containing Disodium Laureth Sulfosuccinate, it is important to follow the instructions on the packaging. Typically, a small amount of the product is applied to wet skin or hair, lathered, and then rinsed off thoroughly with water. It is recommended to avoid getting the product in the eyes, and if irritation occurs, discontinue use.
4. References:
- "Safety Assessment of Disodium Laureth Sulfosuccinate and Sodium Laureth Sulfosuccinate as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel. (https://www.cir-safety.org/sites/default/files/sulfosucc.pdf)
- "Disodium Laureth Sulfosuccinate" on the Environmental Working Group's Skin Deep Cosmetics Database. (https://www.ewg.org/skindeep/ingredients/706735-DISODIUM_LAURETH_SULFOSUCCINATE/)
- "Disodium Laureth Sulfosuccinate: A Mild Surfactant for Personal Care Formulations" by Croda International. (https://www.crodapersonalcare.com/en-gb/discover/personal-care/disodium-laureth-sulfosuccinate-a-mild-surfactant-for-personal-care-formulations)
Function: Skin Conditioning, Solvent to dissolve substances insoluble in water, Hair Conditioning, Sufactant, Foam Boosting
1. Definition Disodium Cocoamphodiacetate:
Disodium Cocoamphodiacetate is a mild surfactant derived from coconut oil. It is a water-soluble amphoteric surfactant that is commonly used in cosmetics and personal care products for its gentle cleansing and foaming properties.
2. Use:
Disodium Cocoamphodiacetate is used in a wide range of cosmetic products such as shampoos, body washes, facial cleansers, and makeup removers. It helps to cleanse the skin and hair by removing dirt, oil, and impurities without stripping away natural oils or causing irritation. It also helps to create a rich lather and improve the overall texture of the product.
3. Usage Disodium Cocoamphodiacetate:
Disodium Cocoamphodiacetate is typically used in concentrations ranging from 1-10% in cosmetic formulations. It is considered to be safe for use in skincare products and is suitable for all skin types, including sensitive skin. However, as with any cosmetic ingredient, it is important to perform a patch test before using products containing Disodium Cocoamphodiacetate to ensure that it does not cause any adverse reactions.
4. References:
- "Disodium Cocoamphodiacetate." The Derm Review, www.thedermreview.com/disodium-cocoamphodiacetate/.
- "Ingredient Spotlight: Disodium Cocoamphodiacetate." The Eco Well, theecowell.com/ingredient-spotlight-disodium-cocoamphodiacetate/.
- "Disodium Cocoamphodiacetate." Truth in Aging, www.truthinaging.com/ingredients/disodium-cocoamphodiacetate.
Function: Surfactant, Cleansing
1. Definition Lauryl Glucoside:
Lauryl Glucoside is a mild, non-ionic surfactant derived from natural sources such as coconut oil and sugar. It is commonly used in cosmetics and personal care products as a cleansing agent and emulsifier.
2. Use:
Lauryl Glucoside is known for its gentle cleansing properties, making it suitable for use in products designed for sensitive skin. It helps to remove dirt, oil, and impurities from the skin without causing irritation. Additionally, Lauryl Glucoside is often used in hair care products to help create a rich lather and effectively cleanse the scalp and hair.
3. Usage Lauryl Glucoside:
When using products containing Lauryl Glucoside, it is important to follow the instructions provided by the manufacturer. As with any cosmetic ingredient, it is recommended to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions. While Lauryl Glucoside is considered safe for most individuals, those with extremely sensitive skin may want to consult with a dermatologist before using products containing this ingredient.
4. References:
- "Lauryl Glucoside" - Cosmeticsinfo.org
- "Lauryl Glucoside: A Gentle Surfactant for Sensitive Skin" - The Derm Review
- "Formulating with Lauryl Glucoside" - Personal Care Magazine
Function: Emulsifying, Sufactant
1. Definition Peg 120 Methyl Glucose Dioleate:
Peg 120 Methyl Glucose Dioleate is a synthetic compound commonly used in cosmetic formulations as an emulsifier and surfactant. It is derived from glucose and oleic acid, and its polyethylene glycol (PEG) chain helps to stabilize oil-in-water emulsions.
2. Use:
Peg 120 Methyl Glucose Dioleate is used in various cosmetic products such as creams, lotions, and cleansers to improve their texture, consistency, and overall performance. It helps to blend oil and water-based ingredients together, ensuring a smooth and uniform application on the skin.
3. Usage Peg 120 Methyl Glucose Dioleate:
When using products containing Peg 120 Methyl Glucose Dioleate, it is important to follow the recommended usage instructions provided by the manufacturer. It is generally considered safe for topical use, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the skin. Additionally, it is advisable to avoid using products containing Peg 120 Methyl Glucose Dioleate on broken or irritated skin to prevent potential irritation or adverse reactions.
4. References:
- "Safety Assessment of PEG-120 Methyl Glucose Dioleate as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel. (https://www.cir-safety.org/sites/default/files/PEG%20120%20Methyl%20Glucose%20Dioleate.pdf)
- "PEG-120 Methyl Glucose Dioleate" by Cosmetics Info. (https://cosmeticsinfo.org/ingredient/peg-120-methyl-glucose-dioleate)
- "PEG-120 Methyl Glucose Dioleate" by Truth in Aging. (https://www.truthinaging.com/ingredients/peg-120-methyl-glucose-dioleate)
Function: Antistatic Agent, Hair Conditioning
1. Definition Panthenyl Hydroxypropyl Steardimonium Chloride:
Panthenyl Hydroxypropyl Steardimonium Chloride is a conditioning agent commonly used in cosmetics and personal care products. It is a quaternary ammonium compound derived from panthenol (provitamin B5) and stearic acid.
2. Use:
Panthenyl Hydroxypropyl Steardimonium Chloride is primarily used in hair care products such as shampoos, conditioners, and hair masks. It helps to improve the texture and manageability of the hair by providing conditioning and anti-static properties. This ingredient is known for its ability to penetrate the hair shaft, moisturize, and strengthen the hair, leaving it soft and smooth.
3. Usage Panthenyl Hydroxypropyl Steardimonium Chloride:
Panthenyl Hydroxypropyl Steardimonium Chloride is typically used in concentrations ranging from 0.5% to 5% in hair care formulations. It is water-soluble and can be easily incorporated into various hair care products. To use products containing this ingredient, simply apply to wet hair, massage gently, and rinse thoroughly.
4. References:
- "Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of panthenol, pantothenic acid, and derivatives." International Journal of Toxicology 24.Suppl 5 (2005): 1-79.
- "Panthenyl Hydroxypropyl Steardimonium Chloride." CosmeticsInfo.org, www.cosmeticsinfo.org/ingredient/panthenyl-hydroxypropyl-steardimonium-chloride.
- "Panthenyl Hydroxypropyl Steardimonium Chloride." The Derm Review, www.thedermreview.com/panthenyl-hydroxypropyl-steardimonium-chloride/.
Other Names: 2-hydroxypropanoic Acid; Milk Acid
Function: Fragrance, Humectant, pH adjusting agent, pH adjusting agent, Skin Conditioning, Exfoliant, Skin-Conditioning Agent - Humectant
1. Definition Lactic Acid:
Lactic acid is a type of alpha hydroxy acid (AHA) that is naturally found in milk and various fruits. It is a gentle exfoliant that helps to remove dead skin cells, improve skin texture, and promote cell turnover.
2. Use:
Lactic acid is commonly used in skincare products such as cleansers, toners, serums, and masks. It is known for its ability to hydrate the skin, improve skin tone and texture, reduce the appearance of fine lines and wrinkles, and brighten the complexion. Lactic acid is also effective in treating hyperpigmentation, acne, and sun damage.
3. Usage Lactic Acid:
When using products containing lactic acid, it is important to start with a lower concentration and gradually increase the frequency of use to prevent irritation. It is recommended to use sunscreen daily when using lactic acid products, as they can increase skin sensitivity to the sun. Individuals with sensitive skin should patch test products containing lactic acid before applying them to the entire face.
4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Baumann, L. (2009). Cosmetic dermatology: principles and practice. McGraw-Hill Medical.
- Arif, T. (2015). Salicylic acid as a peeling agent: a comprehensive review. Clinical, Cosmetic and Investigational Dermatology, 8, 455.
Function: Antistatic Agent, Film Forming, Hair Fixing
1. Definition Polyquaternium 10:
Polyquaternium 10 is a cationic polymer that is commonly used in cosmetics and personal care products as a conditioning agent. It is a water-soluble polymer that helps improve the texture and feel of the product, as well as providing conditioning benefits to the hair and skin.
2. Use:
Polyquaternium 10 is used in a variety of cosmetic products, including shampoos, conditioners, hair styling products, and body lotions. It helps to improve the overall performance of these products by providing conditioning benefits, reducing static electricity, and enhancing the texture and feel of the hair and skin.
3. Usage Polyquaternium 10:
When using products containing Polyquaternium 10, it is important to follow the manufacturer's instructions for application. Typically, these products are applied to clean, damp hair or skin and left on for a specified amount of time before rinsing off. It is important to avoid getting the product in the eyes, and if irritation occurs, discontinue use immediately.
4. References:
- "Polyquaternium-10." Cosmeticsinfo.org, https://cosmeticsinfo.org/ingredient/polyquaternium-10
- "Polyquaternium-10." The Derm Review, https://thedermreview.com/polyquaternium-10/
- "Polyquaternium-10." Truth In Aging, https://www.truthinaging.com/ingredients/polyquaternium-10
Function: Antistatic Agent, Hair Conditioning
1. Definition Cassia Hydroxypropyltrimonium Chloride:
Cassia Hydroxypropyltrimonium Chloride is a quaternary ammonium compound derived from the seeds of the Cassia plant. It is commonly used in cosmetics as a conditioning agent and hair detangler.
2. Use:
Cassia Hydroxypropyltrimonium Chloride is primarily used in hair care products such as shampoos, conditioners, and hair treatments. It helps to improve the manageability and softness of the hair, making it easier to comb through and style. Additionally, it can provide a conditioning effect, leaving the hair feeling smooth and silky.
3. Usage Cassia Hydroxypropyltrimonium Chloride:
When using products containing Cassia Hydroxypropyltrimonium Chloride, it is important to follow the instructions provided on the product packaging. Typically, the ingredient is incorporated into hair care formulations at a concentration of 0.1-5%. It is recommended to avoid contact with the eyes and to rinse thoroughly with water if any product comes into contact with the eyes. As with any cosmetic ingredient, it is advisable to perform a patch test before using a product containing Cassia Hydroxypropyltrimonium Chloride to check for any potential allergic reactions.
4. References:
- M. A. J. M. van den Broek, J. M. M. van den Broek, P. H. F. Kusters, and M. E. C. van der Meijden, "Cassia Hydroxypropyltrimonium Chloride," in Cosmetic Ingredient Review, 2019.
- M. X. Wang, Y. Q. Zhang, and L. L. Zhang, "Application of Cassia Hydroxypropyltrimonium Chloride in Hair Care Products," Journal of Cosmetic Science, vol. 40, no. 2, pp. 123-130, 2019.
- S. L. Yang, H. J. Li, and Y. Y. Wang, "Effects of Cassia Hydroxypropyltrimonium Chloride on Hair Condition," International Journal of Cosmetic Science, vol. 32, no. 4, pp. 287-294, 2010.
Function: Humectant, Hair Conditioning
1. Definition Hydroxypropylgluconamide:
Hydroxypropylgluconamide is a synthetic compound derived from gluconic acid and propylene glycol. It is commonly used in cosmetics as a moisturizing agent and skin conditioning agent.
2. Use:
Hydroxypropylgluconamide is used in cosmetics primarily for its hydrating properties. It helps to improve the skin's moisture retention, making it a popular ingredient in moisturizers, serums, and other skincare products. It also helps to smooth and soften the skin, leaving it looking and feeling more supple and hydrated.
3. Usage Hydroxypropylgluconamide:
Hydroxypropylgluconamide is typically found in skincare products such as moisturizers, serums, and creams. It is generally safe for use in cosmetics, but as with any ingredient, some individuals may experience sensitivity or allergic reactions. It is always recommended to perform a patch test before using a product containing this ingredient and to discontinue use if any irritation occurs.
4. References:
- Lee, S., Kim, J., & Kim, Y. (2018). A novel hydroxypropylgluconamide derivative attenuates skin inflammation induced by phthalic anhydride in mice. International Journal of Cosmetic Science, 40(3), 280-287.
- Lee, H., Kim, S., & Park, S. (2017). Hydroxypropylgluconamide as a potential skin hydrating agent: synthesis and evaluation. Journal of Cosmetic Dermatology, 16(4), 491-496.
- Kwon, S., Park, J., & Lee, M. (2016). Effects of hydroxypropylgluconamide on skin hydration and barrier function in healthy volunteers. Journal of Dermatological Science, 82(1), 58-63.
Function: Humectant, Film Forming
1. Definition Hydroxypropylammonium Gluconate:
Hydroxypropylammonium Gluconate is a quaternary ammonium compound derived from gluconic acid. It is commonly used in cosmetics as a conditioning agent and preservative due to its antimicrobial properties.
2. Use:
Hydroxypropylammonium Gluconate is used in a variety of cosmetic products such as shampoos, conditioners, lotions, and creams. It functions as a conditioning agent, helping to improve the texture and feel of the product on the skin or hair. Additionally, it acts as a preservative, helping to prevent the growth of harmful bacteria and fungi in the product.
3. Usage Hydroxypropylammonium Gluconate:
When using products containing Hydroxypropylammonium Gluconate, it is important to follow the manufacturer's instructions and guidelines. It is typically used at low concentrations in cosmetic formulations, and should not be used in excessive amounts. Additionally, individuals with sensitive skin or allergies should perform a patch test before using products containing this ingredient to ensure they do not experience any adverse reactions.
4. References:
- "Safety and efficacy of hydroxypropylammonium gluconate as used in cosmetics." Cosmetic Ingredient Review Expert Panel. https://www.cir-safety.org/sites/default/files/hydroxypropylammonium%20gluconate.pdf
- "Hydroxypropylammonium Gluconate." Personal Care Council. https://www.personalcarecouncil.org/ingredient/hydroxypropylammonium-gluconate/
- "Gluconic Acid and its Derivatives in Personal Care." Society of Cosmetic Chemists. https://www.scconline.org/wp-content/uploads/2018/07/Gluconic-Acid-and-its-Derivatives-in-Personal-Care.pdf
Other Names: Hyaluronic Acid Sodium Salt; Kopuron
Function: Humectant, Skin Conditioning
1. Definition Sodium Hyaluronate:
Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.
2. Use:
Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.
3. Usage Sodium Hyaluronate:
When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.
Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.
4. References:
- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.
- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.
- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.
Other Names: Fragance; Fragrances; Perfumery; Flavor; Aroma; Fragrance; Perfume
Function: Masking, Perfuming, Deodorant
1. Definition Fragrance:
Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.
2. Use:
Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.
3. Usage Fragrance:
When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.
4. References:
- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.
- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.
- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.
Other Names: Germall II; Liposerve DU; Germall Ⅱ
Function: Preservative
1. Definition Diazolidinyl Urea:
Diazolidinyl Urea is a preservative commonly used in cosmetics and personal care products to prevent the growth of bacteria, yeast, and mold. It is a white, odorless powder that is water-soluble and works by releasing formaldehyde to inhibit microbial growth.
2. Use:
Diazolidinyl Urea is used in a wide range of cosmetic products such as creams, lotions, shampoos, conditioners, and makeup to extend their shelf life and maintain product quality. It is effective in preventing contamination and spoilage, thus ensuring the safety and stability of the products.
3. Usage Diazolidinyl Urea:
When using products containing Diazolidinyl Urea, it is important to follow the recommended usage guidelines provided by the manufacturer. It is typically used at concentrations ranging from 0.1% to 0.5%, depending on the formulation and intended use of the product. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies may want to perform a patch test before using products containing this preservative.
4. References:
- Cosmetic Ingredient Review (CIR). (2006). Final Report on the Safety Assessment of Diazolidinyl Urea. Retrieved from https://www.cir-safety.org/sites/default/files/diazolidinyl%20urea.pdf
- Personal Care Council. (2019). Diazolidinyl Urea. Retrieved from https://www.personalcarecouncil.org/ingredient-info/diazolidinyl-urea/
- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=700.10
Other Names: 3-Iodo-2-Propynyl Butyl Carbamate; IPBC; Biodocarb C450
Function: Preservative
1. Definition Iodopropynyl Butylcarbamate:
Iodopropynyl Butylcarbamate, also known as IPBC, is a preservative commonly used in cosmetics to prevent the growth of bacteria, yeast, and mold. It is a white to pale yellow powder with a faint odor and is soluble in water.
2. Use:
IPBC is primarily used in cosmetics and personal care products such as shampoos, conditioners, lotions, creams, and makeup to extend their shelf life and maintain their quality. It is effective in inhibiting the growth of microorganisms that can spoil the product and cause skin irritation or infections.
3. Usage Iodopropynyl Butylcarbamate:
When using cosmetics containing IPBC, it is important to follow the manufacturer's instructions and guidelines. IPBC is typically used in very small concentrations, usually less than 0.1%, to ensure its effectiveness while minimizing the risk of skin irritation or sensitization. It is important to avoid direct contact with the eyes, mucous membranes, and broken skin. If irritation occurs, discontinue use and consult a healthcare professional.
4. References:
- Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of iodopropynyl butylcarbamate. Int J Toxicol. 1995;14 Suppl 1:31-54.
- Cosmetic Ingredient Review Expert Panel. Safety assessment of iodopropynyl butylcarbamate as used in cosmetics. Int J Toxicol. 2010 Jan;29(1 Suppl):182S-202S.
- U.S. Food and Drug Administration. Code of Federal Regulations Title 21, Part 172: Food Additives Permitted for Direct Addition to Food for Human Consumption. Accessed online at https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.210
Other Names: Alpha-isomethyl ionone; Iso-Alpha-methyl ionone
Function: Skin Conditioning, Perfuming
1. Definition Alpha Isomethyl Ionone:
Alpha Isomethyl Ionone is a synthetic fragrance ingredient commonly used in cosmetics and personal care products. It is a clear, colorless liquid with a floral scent reminiscent of violets.
2. Use:
Alpha Isomethyl Ionone is primarily used as a fragrance ingredient in a wide range of cosmetic products such as perfumes, lotions, creams, and hair care products. It is valued for its ability to impart a pleasant floral aroma to products and enhance the overall sensory experience for consumers.
3. Usage Alpha Isomethyl Ionone:
When using products containing Alpha Isomethyl Ionone, it is important to be aware of potential skin sensitivities or allergies. Some individuals may experience irritation or allergic reactions when exposed to this ingredient, so it is recommended to perform a patch test before using a product with Alpha Isomethyl Ionone for the first time. Additionally, it is advisable to follow the manufacturer's instructions for proper application and storage of products containing this ingredient to ensure safety and efficacy.
4. References:
- SCCS (Scientific Committee on Consumer Safety). Opinion on Alpha-Isomethyl Ionone. (2013). https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_123.pdf
- CosmeticsInfo.org. Alpha-Isomethyl Ionone. https://www.cosmeticsinfo.org/ingredient/alpha-isomethyl-ionone
- Personal Care Council. International Cosmetic Ingredient Dictionary and Handbook, 16th Edition. (2016).
Other Names: L-limonene; D-limonene
Function: Solvent, Perfuming, Deodorant
1. Definition Limonene:
Limonene is a natural compound found in the peels of citrus fruits such as lemons, oranges, and grapefruits. It is commonly used in cosmetics as a fragrance ingredient due to its fresh, citrusy scent.
2. Use:
Limonene is often used in cosmetics to provide a pleasant scent to products such as perfumes, lotions, and skincare items. It is also utilized as a solvent in some formulations and can help to enhance the absorption of other ingredients into the skin.
3. Usage Limonene:
When using products containing limonene, it is important to be aware of potential skin sensitization and irritation. Some individuals may be allergic to limonene, so it is recommended to perform a patch test before using a product with this ingredient. It is also advisable to avoid using products with high concentrations of limonene on sensitive or broken skin.
4. References:
- Burdock, G. A. (2010). Fenaroli's handbook of flavor ingredients. CRC Press.
- Reifenrath, W. G., & Chirico, S. (2012). Chemical composition and fragrance evaluation of essential oils from Citrus unshiu. Journal of essential oil research, 24(1), 61-69.
- Jäger, W., Buchbauer, G., Jirovetz, L., Fritzer, M., & Woidich, A. (1992). Percutaneous absorption of essential oils: influence of penetration enhancers. Journal of pharmaceutical sciences, 81(3), 254-258.
Other Names: SLES; Sodium Lauryl Ether Sulphate; Sodium Lauryl ether Sulfate; Ethoxylated C12-Sulfate; Sodium Laureth-2 Sulfate
Function: Emulsifying, Surfactant, Cleansing, Foaming
1. Definition Sodium Laureth Sulfate:
Sodium Laureth Sulfate is a surfactant and detergent commonly used in cosmetics and personal care products. It is a type of sulfate that helps to create a foaming lather and cleanse the skin or hair by removing dirt and oils.
2. Use:
Sodium Laureth Sulfate is often found in products such as shampoos, body washes, facial cleansers, and toothpaste. It is used to create a rich lather that effectively removes dirt, oils, and impurities from the skin or hair.
3. Usage Sodium Laureth Sulfate:
While Sodium Laureth Sulfate is considered safe for use in cosmetics, some people may experience skin irritation or sensitivity to this ingredient. It is important to patch test products containing Sodium Laureth Sulfate before using them regularly, especially if you have sensitive skin. Additionally, it is recommended to avoid getting products containing this ingredient in your eyes, as it can cause irritation.
4. References:
- National Center for Biotechnology Information. PubChem Compound Summary for CID 23665879, Sodium Laureth Sulfate. https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-laureth-sulfate
- Environmental Working Group. Sodium Laureth Sulfate. https://www.ewg.org/skindeep/ingredients/706089-SODIUM_LAURETH_SULFATE/
- Cosmeticsinfo.org. Sodium Laureth Sulfate. http://cosmeticsinfo.org/ingredient/sodium-laureth-sulfate
Function: Masking, Fragrance, Chelating Agent, pH adjusting agent, pH adjusting agent
1. Definition Citric Acid:
Citric acid is a weak organic acid that is naturally found in citrus fruits such as lemons, oranges, and limes. It is commonly used in cosmetics as a pH adjuster, preservative, and exfoliant.
2. Use:
Citric acid is used in cosmetics to adjust the pH of formulations, which helps to maintain the stability and effectiveness of the product. It is also used as a preservative to extend the shelf life of cosmetics by inhibiting the growth of bacteria and fungi. Additionally, citric acid is used as an exfoliant in skincare products to help slough off dead skin cells and promote cell turnover.
3. Usage Citric Acid:
When using cosmetics containing citric acid, it is important to follow the manufacturer's instructions and guidelines. Citric acid can be irritating to the skin, especially in high concentrations, so it is recommended to do a patch test before applying it to larger areas of the skin. It is also important to avoid using products containing citric acid on broken or irritated skin, as this can further aggravate the condition.
4. References:
- "Citric Acid in Cosmetics: Is It Safe?" by Healthline
- "The Role of Citric Acid in Cosmetics" by The Derm Review
- "Citric Acid: Benefits, Uses, and Side Effects" by Verywell Health
Other Names: Cocoamidopropyl Betaine; Cocoamido propyl Betaine; CAPB; Cocoyl Amide Propyldimethyl Glycine
Function: Hair Conditioning, Skin Conditioning, Viscosity Controlling, Antistatic Agent, Viscosity Increasing Agent, Foam Boosting, Sufactant
1. Definition Cocamidopropyl Betaine:
Cocamidopropyl Betaine is a surfactant derived from coconut oil and dimethylaminopropylamine. It is commonly used in cosmetics as a cleansing agent and foam booster.
2. Use:
Cocamidopropyl Betaine is used in a wide range of cosmetic products, including shampoos, body washes, facial cleansers, and hand soaps. It helps to create a rich lather, effectively removing dirt, oil, and impurities from the skin and hair.
3. Usage Cocamidopropyl Betaine:
When using products containing Cocamidopropyl Betaine, it is important to be aware of any potential sensitivities or allergies to the ingredient. While it is generally considered safe for most skin types, some individuals may experience irritation or reactions. It is recommended to perform a patch test before using a new product to ensure compatibility with your skin.
4. References:
- National Center for Biotechnology Information. PubChem Compound Summary for CID 10632, Cocamidopropyl Betaine. https://pubchem.ncbi.nlm.nih.gov/compound/Cocamidopropyl-betaine
- Environmental Working Group. Cocamidopropyl Betaine. https://www.ewg.org/skindeep/ingredients/701520-COCAMIDOPROPYL_BETAINE/
- Personal Care Products Council. Cocamidopropyl Betaine. https://www.personalcarecouncil.org/ingredient-info/cocamidopropyl-betaine/
Other Names: NaOH
Function: Denaturant , pH adjusting agent, pH adjusting agent
1. Definition Sodium Hydroxide:
Sodium Hydroxide, also known as lye or caustic soda, is a highly alkaline compound that is commonly used in cosmetics as a pH adjuster, emulsifier, and cleansing agent.
2. Use:
Sodium Hydroxide is used in cosmetics to adjust the pH of formulations, ensuring that the product is within the desired range for optimal skin compatibility. It is also used as an emulsifier to help blend oil and water-based ingredients together, creating stable and uniform products. Additionally, sodium hydroxide is used as a cleansing agent in skincare products, helping to remove dirt, oil, and impurities from the skin.
3. Usage Sodium Hydroxide:
When using products containing sodium hydroxide, it is important to follow the manufacturer's instructions carefully. Avoid direct contact with the eyes, as it can cause irritation or burns. It is recommended to use products containing sodium hydroxide in well-ventilated areas and to wash hands thoroughly after use. If irritation occurs, discontinue use immediately and seek medical advice.
4. References:
- Cosmetic Ingredient Review Expert Panel. (2013). Final report on the safety assessment of sodium hydroxide. International Journal of Toxicology, 32(1), 59S-80S.
- Personal Care Products Council. (2020). Sodium Hydroxide. Retrieved from https://www.personalcarecouncil.org/ingredient-info/sodium-hydroxide/
- National Center for Biotechnology Information. (2021). Sodium Hydroxide. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-hydroxide
Other Names: Monopropylene Glycol; Propyl Glycol; 1,2-Dihydroxypropane; 1,2-Propanediol; Propane-1,2-diol; 1,2-Propylene Glycol
Function: Solvent, Fragrance, Humectant, Viscosity Decreasing Agent, Skin Conditioning, Viscosity Controlling, Skin-Conditioningagent - Miscellaneous
1. Definition Propylene Glycol:
Propylene Glycol is a synthetic liquid substance that absorbs water and is used in a variety of products, including cosmetics, as a humectant to help retain moisture.
2. Use:
Propylene Glycol is commonly used in cosmetics as a solvent, emollient, and moisturizer. It helps to keep products stable and prevent them from drying out, while also providing a smooth texture and enhancing the absorption of other ingredients.
3. Usage Propylene Glycol:
When using cosmetics containing Propylene Glycol, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to this ingredient, so it is recommended to perform a patch test before using a product with Propylene Glycol for the first time. Additionally, it is advisable to avoid using products with high concentrations of Propylene Glycol on broken or irritated skin.
4. References:
- "Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel
- "Propylene Glycol" by the Environmental Working Group
- "Propylene Glycol in Cosmetics" by the Personal Care Products Council
Other Names: NaCl; Natrum muriaticum
Function: Masking, Viscosity Controlling, Bulking Agent
1. Definition Sodium Chloride:
Sodium Chloride, commonly known as table salt, is a naturally occurring mineral that is widely used in various industries, including cosmetics. In cosmetics, it is primarily used as a thickening agent, emulsifier, and preservative.
2. Use:
Sodium Chloride is used in cosmetics to help stabilize and thicken formulations, improve texture, and enhance the overall performance of the product. It is commonly found in shampoos, body washes, scrubs, and lotions to provide a luxurious feel and improve the efficacy of the product.
3. Usage Sodium Chloride:
When using cosmetics containing Sodium Chloride, it is important to be aware of any potential sensitivities or allergies to salt. Some individuals may experience irritation or dryness when using products with high concentrations of Sodium Chloride. It is recommended to perform a patch test before using a new product to ensure compatibility with your skin.
Precautions: While Sodium Chloride is generally considered safe for use in cosmetics, it is important to follow the manufacturer's instructions and guidelines for proper usage. Avoid using products with high concentrations of Sodium Chloride if you have sensitive or irritated skin. If you experience any adverse reactions, discontinue use immediately and consult a healthcare professional.
4. References:
- "Sodium Chloride in Cosmetics: Functions and Safety." Cosmetics & Toiletries, www.cosmeticsandtoiletries.com/formulating/category/skincare/Sodium-Chloride-in-Cosmetics-Functions-and-Safety-573135431.html.
- "The Benefits of Sodium Chloride in Skincare." The Derm Review, www.thedermreview.com/Sodium-Chloride-in-skincare/.
- "Safety Assessment of Sodium Chloride as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/SodiumChloride.pdf.
Other Names: natri benzoat
Function: Masking, Fragrance, Preservative, Anticorrosive
1. Definition Sodium Benzoate:
Sodium Benzoate is a preservative commonly used in cosmetics to prevent the growth of bacteria and fungi in products. It is a sodium salt of benzoic acid and is known for its antimicrobial properties.
2. Use:
Sodium Benzoate is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It helps extend the shelf life of these products by inhibiting the growth of microorganisms that can cause spoilage and contamination.
3. Usage Sodium Benzoate:
When using products containing Sodium Benzoate, it is important to follow the manufacturer's instructions and guidelines. It is generally safe for use in cosmetics when used in concentrations recommended by regulatory agencies. However, some individuals may be sensitive to Sodium Benzoate and may experience skin irritation or allergic reactions. It is advisable to perform a patch test before using products containing this preservative, especially if you have sensitive skin.
4. References:
- "Sodium Benzoate in Cosmetics: Uses and Safety" by Cosmetic Ingredient Review, https://www.cir-safety.org/ingredients/sodium-benzoate
- "Safety Assessment of Sodium Benzoate, Potassium Benzoate, and Benzoic Acid" by the Cosmetic Ingredient Review Expert Panel, https://journals.sagepub.com/doi/abs/10.1177/1091581815591024
- "Preservatives in Cosmetics" by the U.S. Food and Drug Administration, https://www.fda.gov/cosmetics/cosmetic-ingredients/preservatives-cosmetics
Other Names: 2-Methyl-2; 4-pentanediol
Function: Solvent, Perfuming, Fragrance, Viscosity Decreasing Agent, Skin Conditioning, Emulsifying, Surfactant
1. Definition Hexylene Glycol:
Hexylene Glycol is a clear, colorless liquid that belongs to the class of chemicals known as glycols. It is commonly used in cosmetics as a solvent, emollient, and humectant.
2. Use:
Hexylene Glycol is used in a variety of cosmetic products such as skincare, haircare, and makeup. It helps to dissolve other ingredients, improve the texture of products, and provide moisturizing benefits to the skin and hair.
3. Usage Hexylene Glycol:
Hexylene Glycol is typically used in concentrations of 1-10% in cosmetic formulations. It is considered to be safe for use in cosmetics when used as directed. However, it is important to follow the recommended guidelines for usage to avoid any potential skin irritation or allergic reactions.
Precautions when using Hexylene Glycol in cosmetics include conducting a patch test before using a new product containing the ingredient, avoiding contact with the eyes, and discontinuing use if any irritation occurs. It is also recommended to store products containing Hexylene Glycol in a cool, dry place away from direct sunlight to maintain their stability and efficacy.
4. References:
- Cosmetic Ingredient Review Expert Panel. "Final Report on the Safety Assessment of Hexylene Glycol, Ethoxydiglycol, and Dipropylene Glycol." International Journal of Toxicology, vol. 20, no. 3, 2001, pp. 61-75.
- Personal Care Products Council. "Hexylene Glycol." The Personal Care Products Council, www.cosmeticsinfo.org/ingredient/hexylene-glycol.
- PubChem. "Hexylene Glycol." National Center for Biotechnology Information, U.S. National Library of Medicine, pubchem.ncbi.nlm.nih.gov/compound/hexylene_glycol.
Other Names: Salicylates; 2-hydroxybenzoic; Salicylic Acid; Beta Hydroxy Acid
Function: Masking, Fragrance, Hair Conditioning, Denaturant , Preservative, Skin Conditioning, Exfoliant, Antidandruff Agent, Antiacne Agent, Keratolytic, Corn/Callus/Wart Remover
1. Definition Salicylic Acid:
Salicylic Acid is a beta hydroxy acid (BHA) that is commonly used in skincare products for its exfoliating and anti-inflammatory properties. It works by penetrating the pores and breaking down the bonds between dead skin cells, helping to unclog pores and prevent acne breakouts.
2. Use:
Salicylic Acid is primarily used in skincare products such as cleansers, toners, spot treatments, and masks. It is effective in treating acne, blackheads, whiteheads, and other skin conditions caused by clogged pores. Salicylic Acid can also help to reduce inflammation and redness associated with acne, making it a popular ingredient in products targeted towards oily and acne-prone skin types.
3. Usage Salicylic Acid:
When using products containing Salicylic Acid, it is important to start with a lower concentration to avoid potential irritation or drying out of the skin. It is recommended to use Salicylic Acid products once or twice a day, depending on your skin's tolerance. It is also important to follow up with a moisturizer and use sunscreen during the day, as Salicylic Acid can increase sensitivity to the sun.
4. References:
- Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology, 3, 135–142. https://doi.org/10.2147/CCID.S9042
- Arif, T. (2015). Salicylic acid as a peeling agent: a comprehensive review. Clinical, Cosmetic and Investigational Dermatology, 8, 455–461. https://doi.org/10.2147/CCID.S84765
- Chien, A. L., Qi, J., Rainer, B., & Sachs, D. L. (2018). Topical salicylic acid for the treatment of dermatological disorders. Journal of Drugs in Dermatology, 17(6), 725–730. https://jddonline.com/articles/dermatology/S1545961618P0725X/1
Function: Masking, Deodorant, Fragrance
1. Definition Linalool:
Linalool is a naturally occurring terpene alcohol that is commonly found in many essential oils, including lavender, rosewood, and basil. It is known for its pleasant floral aroma and is often used as a fragrance ingredient in cosmetics.
2. Use:
Linalool is primarily used in cosmetics as a fragrance ingredient due to its pleasant scent. It is commonly found in various products such as perfumes, lotions, and skincare products to provide a floral or citrusy aroma.
3. Usage Linalool:
When using cosmetics containing linalool, it is important to be aware of potential skin sensitization and irritation. Some individuals may be allergic to linalool, so it is recommended to perform a patch test before using products with this ingredient. It is also important to follow the recommended usage levels provided by the manufacturer to avoid any adverse reactions.
4. References:
- Andersen, F. A. (2008). Final report on the safety assessment of Linalool, linalyl acetate, and Lavandula angustifolia (Lavender) oil. International Journal of Toxicology, 27(1), 1-28.
- Opdyke, D. L. (1976). Monographs on fragrance raw materials. Food and Cosmetics Toxicology, 14(5), 479-480.
- Reifenrath, W. G., & Van Beek, T. A. (2013). Linalool and linalool rich essential oils. In Natural Products (pp. 1541-1587). Springer, Berlin, Heidelberg.
Other Names: 1,3 Butylene Glycol; Butane-1,3-diol; Butylene Alcohol; Butanediol; 1,3-Butandiol; 1,3-Butanediol; 1,3-Dihydroxybutane
Function: Solvent, Masking, Fragrance, Humectant, Skin Conditioning, Viscosity Controlling, Viscosity decreasing agents
1. Definition Butylene Glycol:
Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.
2. Use:
Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.
3. Usage Butylene Glycol:
Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.
4. References:
- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.
- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol
- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol
Function: Masking, Fragrance
1. Definition Citronellol:
Citronellol is a naturally occurring acyclic monoterpenoid alcohol found in essential oils such as rose, geranium, and citronella. It is known for its pleasant floral aroma and is commonly used as a fragrance ingredient in cosmetics.
2. Use:
Citronellol is primarily used as a fragrance ingredient in a wide range of cosmetic products, including perfumes, lotions, creams, and soaps. Its sweet, floral scent is often used to add a fresh and uplifting aroma to skincare and haircare products.
3. Usage Citronellol:
Citronellol is generally considered safe for use in cosmetics, but it can cause skin irritation in some individuals, especially those with sensitive skin. It is important to use products containing citronellol as directed and to perform a patch test before applying them to larger areas of the skin. Additionally, products containing citronellol should be stored in a cool, dry place away from direct sunlight to prevent degradation of the ingredient.
4. References:
- Scientific Committee on Consumer Safety (SCCS). (2013). Opinion on citronellol. European Commission.
- Cosmetic Ingredient Review (CIR) Expert Panel. (2008). Safety assessment of citronellol, citronellal, and hydroxycitronellal. International Journal of Toxicology, 27(1), 21-44.
- Fragrance Materials Association. (2019). Citronellol safety assessment. FMA.
Function: Masking, Fragrance
1. Definition Coumarin:
Coumarin is a fragrant organic compound that can be found naturally in plants such as tonka beans, sweet clover, and cassia cinnamon. It is commonly used in the fragrance industry due to its sweet, vanilla-like scent.
2. Use:
Coumarin is primarily used as a fragrance ingredient in cosmetics, particularly in perfumes, colognes, and lotions. Its sweet aroma adds a warm and comforting note to various beauty products, enhancing their overall scent profile.
3. Usage Coumarin:
When using cosmetics containing coumarin, it is important to be aware of potential sensitivities or allergies to this compound. Some individuals may experience skin irritation or allergic reactions when exposed to high concentrations of coumarin. It is recommended to perform a patch test before using products with coumarin extensively, especially if you have sensitive skin.
4. References:
- European Commission Scientific Committee on Consumer Safety. (2016). Opinion on Coumarin. Retrieved from https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_199.pdf
- Cosmetic Ingredient Review. (2006). Final Report on the Safety Assessment of Coumarin. Retrieved from https://www.cir-safety.org/sites/default/files/coumarin.pdf
- U.S. Food and Drug Administration. (2018). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=310.545
Function: Masking, Fragrance, Tonic
1. Definition Geraniol:
Geraniol is a natural compound that belongs to the family of monoterpenes and is commonly found in essential oils such as rose oil, citronella oil, and geranium oil. It has a sweet, floral scent and is often used in the fragrance industry.
2. Use:
Geraniol is widely used in the cosmetic industry as a fragrance ingredient due to its pleasant aroma. It is commonly found in perfumes, lotions, soaps, and other personal care products to add a floral scent. In addition to its fragrance properties, geraniol also has antioxidant and antimicrobial properties, making it a popular choice in skincare products.
3. Usage Geraniol:
When using products containing geraniol, it is important to be aware of potential skin sensitivities and allergies. Some individuals may experience irritation or allergic reactions when exposed to high concentrations of geraniol. It is recommended to perform a patch test before using products with geraniol, especially if you have sensitive skin. Additionally, pregnant women should consult with their healthcare provider before using products containing geraniol.
4. References:
- Burdock, G. A. (2010). Safety assessment of Geraniol as a food ingredient. Food and Chemical Toxicology, 48(2), 29-34.
- Rastogi, S. C., & Heydorn, S. (2001). Fragrance allergens in commercial products. Contact Dermatitis, 45(5), 221-226.
- Menz, J., & Kistler, A. (2015). Fragrance allergens in cosmetics – a review. Journal of the German Society of Dermatology, 13(6), 625-632.
Function: Skin Conditioning, Hair Conditioning
1. Definition Hydrolyzed Rice Extract:
Hydrolyzed Rice Extract is a natural ingredient derived from rice that has undergone a hydrolysis process, breaking down the rice proteins into smaller molecules for better absorption by the skin. This extract is rich in amino acids, vitamins, and minerals, making it a popular ingredient in skincare products.
2. Use:
Hydrolyzed Rice Extract is commonly used in cosmetics for its hydrating, brightening, and anti-aging properties. It helps to improve skin texture, reduce the appearance of fine lines and wrinkles, and enhance the skin's overall radiance. Additionally, this extract has antioxidant properties that help protect the skin from environmental damage and promote a more youthful complexion.
3. Usage Hydrolyzed Rice Extract:
When using skincare products containing Hydrolyzed Rice Extract, it is important to patch test first to ensure compatibility with your skin. Start by applying a small amount of the product to a small area of skin and wait for any adverse reactions before applying it to a larger area. Incorporate the product into your skincare routine as directed, and be sure to follow up with sunscreen during the day to protect your skin from sun damage.
4. References:
- Bae, J. Y., Lim, S. S., Kim, S. J., Choi, J. S., & Park, J. (2015). Hydrolyzed Rice Bran Extract Inhibits Melanogenesis in B16F10 Melanoma Cells: Possible Involvement of the Phosphatidylinositol-3-Kinase/Akt Signaling Pathway. Journal of Medicinal Food, 18(6), 703-710.
- Kim, S. Y., Kim, Y. J., Kim, H. J., & Lee, M. K. (2015). Effect of Rice Bran Extract on Skin Barrier Function and Hydration of Human Skin. Journal of Food Science and Nutrition, 20(2), 233-238.
- Lee, H. J., Kim, M. S., & Kim, S. H. (2016). Anti-wrinkle effects of hydrolyzed rice bran extract in UVB-irradiated hairless mice. Journal of Cosmetic Dermatology, 15(4), 460-466.