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| EWG | CIR | Ingredient Name & Cosmetic Function | Notes |
|---|---|---|---|
| 1 | - | (Solvent) | |
| 1 2 | A | (Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant ) | Good for dry skin Moisturizing |
| 1 | - | (Viscosity Controlling, Emulsion Stabilising) | |
| 1 | A | (Solvent) | |
| 2 4 | A | (Fragrance, Preservative) | |
| 3 4 | A | (Fragrance, Preservative) | Paraben |
| 1 3 | B | (Perfuming, Fragrance, Emulsifying, Surfactant) | Fungal Acne Trigger Cleansing |
| 2 | A | (Chelating Agent) | |
| 1 | A | (Humectant, Skin Conditioning) | Good for dry skin Promotes Wound Healing |
| 8 | - | (Masking, Perfuming, Deodorant) | Fragrance-free |
| 2 | A | (Deodorant, Skin Conditioning) | |
| 1 | A | (Solvent, Skin Conditioning) | |
| 1 | A | (Skin Conditioning, Bulking Agent) | Good for dry skin |
| 5 | - | (Cosmetic Colorant) | |
| 1 | - | (Cosmetic Colorant) | |
| 2 | - | (Cosmetic Colorant) | |
| 1 | - | (Cosmetic Colorant) | |
| 3 | - | (Cosmetic Colorant) | |
| 3 | - | (Colorant, Cosmetic Colorant) | |
| 2 | - | (Colorant, Cosmetic Colorant) | |
| EWG | CIR | Ingredient Name & Cosmetic Function | Notes |
|---|---|---|---|
| 1 | - | (Skin Conditioning, Emollient) | |
| 1 | A | (Solvent, Perfuming, Fragrance, Skin Conditioning, Emollient) | |
| 1 | - | (Skin Conditioning) | |
| 1 | A | (Emollient, Antifoaming Agent, Skin-Conditioning Agent - Occlusive) | |
| 1 | A | (Viscosity Controlling, Abrasive, Bulking Agent, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Film Forming, Adhesive) | |
| 1 | A | (Solvent, Masking, Perfuming, Skin Conditioning, Emollient) | |
| 1 | A | | |
| 1 | A | (Skin Conditioning) | |
| 2 | - | (Cosmetic Colorant, Opacifying) | |
| 1 | B | (Abrasive, Bulking Agent, Opacifying) | |
| 1 | B | (Viscosity Controlling, Suspending Agent - Nonsurfactant, Gel Forming) | |
| 1 | A | (Solvent, Viscosity Decreasing Agent, Viscosity Controlling) | |
| 2 9 | - | (Skin Protecting, Cosmetic Colorant, Sunscreen Agent, Bulking Agent) | UV Protection Good for oily skin Moisturizing |
| 1 | - | (Masking, Fragrance, Flavoring Agent, Soothing) | Fragrance-free |
| 1 | - | (Skin Conditioning) | |
| 1 | A | (Viscosity Controlling, Viscosity Increasing Agent, Bulking Agent) | |
| 1 | B | (Skin Conditioning, Perfuming, Emollient, Fragrance) | Bad for oily skin Fungal Acne Trigger |
| 5 8 | A | (Skin Protecting, Opacifying, Abrasive, Absorbent, Bulking Agent, Anticaking Agent, Slip Modifier) | Moisturizing |
| 1 | A | (Solvent, Masking, Fragrance, Hair Conditioning, Skin Conditioning, Emollient, Antistatic Agent, Emulsifying, Surfactant, Skin-Conditioning Agent - Occlusive) | Bad for oily skin Cleansing |
| 1 | B | (Skin Conditioning) | Promotes Wound Healing |
| 1 | A | (Antioxidant) | |
| 2 | A | (Opacifying, Viscosity Controlling, Abrasive, Bulking Agent) | |
| 1 | A | (Solvent, Skin Conditioning, Emollient, Viscosity Controlling, Viscosity Increasing Agent) | |
| 1 | A | (Humectant, Skin Conditioning) | Good for dry skin Promotes Wound Healing |
| 3 | A | (Masking, Fragrance, Antioxidant) | |
| - | - | (Skin Conditioning, Skin Protecting) | Moisturizing |
| 1 3 | - | (Cosmetic Colorant, Uv Absorber, Sunscreen Agent, Opacifying) | UV Protection Good for sensitive skin |
| 1 2 | - | (Colorant, Cosmetic Colorant) | |
| 1 | - | (Colorant, Cosmetic Colorant) | |
| 1 | - | | |
| 2 | - | (Colorant, Cosmetic Colorant) | |
| - | - | |
Water
1. Definition Water:
Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.2. Use:
Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.3. Usage Water:
When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.
- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.
Glycerin
1. Definition Glycerin:
Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.
2. Use:
Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.
3. Usage Glycerin:
When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.
Polyacrylate Crosspolymer 6
1. Definition Polyacrylate Crosspolymer 6:
Polyacrylate Crosspolymer 6 is a synthetic polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is a crosslinked polymer of acrylic acid that forms a gel-like consistency when hydrated.2. Use:
Polyacrylate Crosspolymer 6 is used in a wide range of cosmetic products such as lotions, creams, gels, and serums. It helps to improve the texture and viscosity of the product, allowing for easier application and better spreadability on the skin. Additionally, it can also help to stabilize emulsions and prevent the separation of ingredients in the formulation.3. Usage Polyacrylate Crosspolymer 6:
When using products containing Polyacrylate Crosspolymer 6, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with this ingredient to ensure compatibility with your skin. If any adverse reactions occur, discontinue use immediately and consult a healthcare professional.4. References:
- "Polyacrylate Crosspolymer 6" in CosmeticsInfo.org, https://cosmeticsinfo.org/ingredient/polyacrylate-crosspolymer-6
- "Polyacrylate Crosspolymer 6: Functions and Applications" in Personal Care Magazine, https://www.personalcaremagazine.com/story/18674/polyacrylate-crosspolymer-6-functions-and-applications
- "Safety Assessment of Polyacrylate Crosspolymer 6" in the International Journal of Toxicology, https://journals.sagepub.com/doi/abs/10.1177/1091581818783125
1,2-Hexanediol
1. Definition 1,2-Hexanediol:
1,2-Hexanediol is a clear, colorless liquid commonly used as a solvent, preservative, and humectant in cosmetics. It is a type of glycol that is derived from petroleum.2. Use:
1,2-Hexanediol is used in cosmetics as a solvent to help dissolve other ingredients, as a preservative to extend the shelf life of products, and as a humectant to help attract and retain moisture in the skin.3. Usage 1,2-Hexanediol:
When using products containing 1,2-Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing 1,2-Hexanediol to determine if any sensitivity exists.4. References:
- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol
- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/
- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820
Phenoxyethanol
1. Definition Phenoxyethanol:
Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.2. Use:
Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.3. Usage Phenoxyethanol:
When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.
Methylparaben
1. Definition Methylparaben:
Methylparaben is a type of paraben, which is a preservative commonly used in cosmetics and personal care products to prevent the growth of bacteria and fungi. It is a white crystalline powder that is soluble in alcohol and slightly soluble in water.2. Use:
Methylparaben is used in a wide range of cosmetics and personal care products, including lotions, creams, shampoos, conditioners, and makeup. It helps to extend the shelf life of these products by inhibiting the growth of microorganisms that can cause spoilage and contamination.3. Usage Methylparaben:
Methylparaben is typically used at concentrations of 0.1% to 0.5% in cosmetics and personal care products. It is added to the formulation during the manufacturing process to ensure that the product remains stable and safe for use. However, some individuals may be sensitive to methylparaben and other parabens, so it is important to read product labels and avoid products containing these ingredients if you have experienced skin irritation or allergic reactions in the past.4. References:
- Cosmetic Ingredient Review Expert Panel. (2008). Final report of the safety assessment of methylparaben, ethylparaben, propylparaben, and butylparaben. International Journal of Toxicology, 27(4), 1-82.
- SCCS (Scientific Committee on Consumer Safety). (2011). Opinion on parabens. European Commission, Health & Consumers Directorate-General.
- Soni, M. G., Carabin, I. G., & Burdock, G. A. (2005). Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food and Chemical Toxicology, 43(7), 985-1015.
Peg 40 Hydrogenated Castor Oil
1. Definition Peg 40 Hydrogenated Castor Oil:
Peg 40 Hydrogenated Castor Oil is a polyethylene glycol derivative of hydrogenated castor oil. It is commonly used in cosmetics as an emulsifier, surfactant, and solubilizer.2. Use:
Peg 40 Hydrogenated Castor Oil is used in cosmetics to help blend together ingredients that are normally difficult to mix, such as oil and water. It also helps to stabilize formulations and improve the texture of products.3. Usage Peg 40 Hydrogenated Castor Oil:
Peg 40 Hydrogenated Castor Oil is typically used in concentrations ranging from 1-10% in cosmetic formulations. It is often found in creams, lotions, serums, and other skincare products. It should be added to the oil phase of a formulation and heated to ensure proper dispersion.Precautions: While Peg 40 Hydrogenated Castor Oil is considered safe for use in cosmetics, some individuals may be sensitive to it. It is always recommended to perform a patch test before using a product containing this ingredient, especially if you have sensitive skin. Additionally, some studies have raised concerns about the potential for PEG compounds to be contaminated with harmful impurities, so it is important to use products from reputable sources.
4. References:
- "PEG-40 Hydrogenated Castor Oil." Cosmetics Info, www.cosmeticsinfo.org/ingredient/peg-40-hydrogenated-castor-oil.
- "PEG-40 Hydrogenated Castor Oil." Truth In Aging, www.truthinaging.com/ingredients/peg-40-hydrogenated-castor-oil.
- "PEG-40 Hydrogenated Castor Oil." Paula's Choice Skincare, www.paulaschoice.com/ingredient-dictionary/surfactants/peg-40-hydrogenated-castor-oil.
Tetrasodium Edta
1. Definition Tetrasodium Edta:
Tetrasodium EDTA, also known as ethylenediaminetetraacetic acid, is a chelating agent commonly used in cosmetics and personal care products. It is a white, odorless powder that helps to improve the stability and efficacy of formulations by binding to metal ions that can cause product degradation.2. Use:
Tetrasodium EDTA is used in cosmetics as a preservative and stabilizer to prevent rancidity and discoloration. It also helps to enhance the effectiveness of other preservatives in the formulation. Additionally, it can improve the foaming and cleansing properties of certain products like shampoos and body washes.3. Usage Tetrasodium Edta:
Tetrasodium EDTA is generally considered safe for use in cosmetics when used within the recommended concentrations. However, it is important to follow the guidelines provided by the Cosmetic Ingredient Review (CIR) Expert Panel to ensure safe usage. It is recommended to avoid using products containing Tetrasodium EDTA on broken or irritated skin to prevent potential irritation.4. References:
- Cosmetic Ingredient Review (CIR) Expert Panel. (2008). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 27(Suppl 1), 93-128.
- Personal Care Products Council. (2019). Tetrasodium EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/tetrasodium-edta/
- U.S. Food and Drug Administration. (2021). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1751
Sodium Hyaluronate
1. Definition Sodium Hyaluronate:
Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.2. Use:
Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.3. Usage Sodium Hyaluronate:
When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.
4. References:
- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.
- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.
- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.
Fragrance
1. Definition Fragrance:
Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.
2. Use:
Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.
3. Usage Fragrance:
When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.
4. References:
- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.
- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.
- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.
Ethylhexylglycerin
1. Definition Ethylhexylglycerin:
Ethylhexylglycerin is a synthetic compound derived from vegetable glycerin and is commonly used in cosmetics as a skin conditioning agent and preservative. It is a clear, colorless liquid with a faint odor.2. Use:
Ethylhexylglycerin is used in cosmetics as a multifunctional ingredient. It acts as a skin conditioning agent, moisturizer, and preservative. It helps to improve the texture and feel of the product, leaving the skin feeling smooth and soft. Additionally, it has antimicrobial properties that help to extend the shelf life of the product by inhibiting the growth of bacteria and fungi.3. Usage Ethylhexylglycerin:
Ethylhexylglycerin is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often found in skincare products such as moisturizers, lotions, creams, and serums. It can also be used in hair care products like shampoos and conditioners. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing Ethylhexylglycerin to check for any potential allergic reactions.4. References:
- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.
- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.
- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.
Pentylene Glycol
1. Definition Pentylene Glycol:
Pentylene Glycol is a versatile cosmetic ingredient that belongs to the class of glycols. It is a clear, colorless liquid with a slightly sweet odor. Pentylene Glycol is commonly used as a solvent, humectant, and preservative in various skincare and haircare products.2. Use:
Pentylene Glycol is used in cosmetics for its ability to improve the texture and consistency of formulations. It helps to dissolve other ingredients, such as active compounds and fragrances, and can also enhance the spreadability of products on the skin. Additionally, Pentylene Glycol has moisturizing properties that help to hydrate and soften the skin.3. Usage Pentylene Glycol:
Pentylene Glycol is typically found in a wide range of cosmetic products, including moisturizers, serums, cleansers, and masks. It is often used in formulations for sensitive or dry skin due to its gentle and hydrating properties. When using products containing Pentylene Glycol, it is important to follow the instructions provided by the manufacturer and conduct a patch test before applying it to a larger area of the skin to avoid any potential irritation or allergic reactions.4. References:
- Ishikawa, A., Yamanaka, K., Sakata, K., & Lida, T. (2017). Effects of pentylene glycol on skin hydration. Journal of Dermatological Science, 86(2), e36.
- Lode, O., & Wohlrab, J. (2015). Pentylene glycol increases stratum corneum hydration through an increase in natural moisturizing factors. Skin Pharmacology and Physiology, 28(1), 47-55.
- Lee, J. H., Kim, S. H., & Han, S. H. (2019). Safety evaluation of pentylene glycol in cosmetic products. Journal of Toxicology and Environmental Health, Part B, 22(2), 83-91.
Beta Glucan
1. Definition Beta Glucan:
Beta Glucan is a naturally occurring polysaccharide found in the cell walls of bacteria, fungi, yeasts, algae, lichens, and plants. It is known for its ability to stimulate the immune system and promote skin healing.2. Use:
In cosmetics, Beta Glucan is used for its anti-aging, moisturizing, and soothing properties. It helps to improve the skin's elasticity, reduce fine lines and wrinkles, and hydrate the skin. Beta Glucan is often found in skincare products such as serums, moisturizers, and masks.3. Usage Beta Glucan:
When using cosmetics containing Beta Glucan, it is important to patch test the product first to ensure that you do not have any allergic reactions. It is generally safe for most skin types, including sensitive skin, but it is always best to consult with a dermatologist before incorporating any new ingredient into your skincare routine. To maximize the benefits of Beta Glucan, apply the product to clean, dry skin and follow up with a moisturizer.4. References:
- Choi, J. K., Kim, S. H. (2018). Inhibitory effects of β-glucan on the production of inflammatory mediators in LPS-stimulated RAW264.7 macrophages. The Journal of Nutritional Biochemistry, 54, 72-80.
- Kim, H. S., Hong, J. T., Kim, Y., Han, S. B. (2016). Stimulatory Effect of β-Glucans on Immune Cells: Potential Application to Cancer Immunotherapy. Anti-Cancer Agents in Medicinal Chemistry, 16(1), 30-37.
- Zykova, T. A., Zhu, F., Zhai, X., Ma, W. Y., Ermakova, S. P., Lee, K. W., Bode, A. M., Dong, Z. (2005). Resveratrol directly targets COX-2 to inhibit carcinogenesis. Molecular Carcinogenesis, 45(10), 842-851.
CI 16255
1. Definition CI 16255:
CI 16255, also known as Acid Red 18, is a synthetic colorant commonly used in cosmetics to add a red hue to various products.2. Use:
CI 16255 is primarily used as a colorant in cosmetics, including lipsticks, blushes, eyeshadows, and nail polishes. It provides a vibrant red shade that enhances the overall appearance of the product.3. Usage CI 16255:
When using cosmetics containing CI 16255, it is important to follow the manufacturer's instructions and recommendations. It is advised to perform a patch test on a small area of skin before applying the product to ensure there are no allergic reactions or sensitivities. Additionally, individuals with sensitive skin or skin conditions should consult with a dermatologist before using products with CI 16255 to avoid any potential irritation.4. References:
- "Safety Assessment of CI 16255 (Acid Red 18) and Acid Orange 7" by the Cosmetic Ingredient Review Expert Panel
- "Color Additives Permitted for Use in Cosmetics" by the U.S. Food and Drug Administration
- "Toxicological Evaluation of Some Food Additives Including Anticaking Agents, Antimicrobials, Antioxidants, Emulsifiers, and Thickening Agents" by the World Health Organization
CI 45410
1. Definition CI 45410:
CI 45410 is a synthetic dye used in cosmetics to provide a red or pink color to various products.2. Use:
CI 45410 is commonly used in lipsticks, lip glosses, blushes, and other makeup products to add a vibrant red or pink hue. It is also used in some hair dyes and nail polishes.3. Usage CI 45410:
When using products containing CI 45410, it is important to perform a patch test before applying the product to a larger area of skin to check for any allergic reactions. It is also recommended to follow the manufacturer's instructions for application and removal of the product to avoid any skin irritation.4. References:
- Cosmetic Ingredient Review Expert Panel. "Final Report on the Safety Assessment of Red 28." International Journal of Toxicology, vol. 19, no. 3, 2000, pp. 1-10.
- Food and Drug Administration. "Code of Federal Regulations Title 21." U.S. Government Publishing Office, 2019.
- Lefebvre, M. A., et al. "Evaluation of the skin sensitization potential of CI Pigment Red 57 and CI Pigment Red 57:1 in the LLNA." Food and Chemical Toxicology, vol. 47, no. 4, 2009, pp. 798-805.
CI 17200
1. Definition CI 17200:
CI 17200 is a synthetic dye commonly known as Red 33. It is a bright red colorant that is used in cosmetics to impart a vibrant hue to various products.2. Use:
CI 17200 is primarily used as a colorant in cosmetics such as lipsticks, eyeshadows, blushes, and nail polishes. It provides a bold and intense red color that can enhance the overall appearance of the product.3. Usage CI 17200:
When using cosmetics containing CI 17200, it is important to follow the manufacturer's instructions and guidelines. Avoid direct eye contact and ingestion of the product. Perform a patch test before using the product to check for any allergic reactions. Discontinue use if any irritation or adverse reactions occur.4. References:
- "Safety Assessment of CI 17200" by Cosmetic Ingredient Review (CIR)
- "Evaluation of the mutagenic and genotoxic potential of CI 17200" by European Commission Scientific Committee on Consumer Safety (SCCS)
- "Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products" by European Union
CI 15985
1. Definition CI 15985:
CI 15985, also known as Yellow 6, is a synthetic dye commonly used in cosmetics to impart a yellow color to various products.2. Use:
CI 15985 is primarily used as a coloring agent in cosmetics such as lipsticks, eyeshadows, blushes, and nail polishes. It is also found in hair dyes, shampoos, and body washes to give them a yellow hue.3. Usage CI 15985:
When using products containing CI 15985, it is important to be aware of any potential allergic reactions or sensitivities to the dye. Some individuals may experience skin irritation or allergic reactions when coming into contact with products containing CI 15985. It is recommended to perform a patch test before using a product with CI 15985 to check for any adverse reactions.4. References:
- "Safety Assessment of CI 15985 (Yellow 6) as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel
- "Color Additives Permitted for Use in Cosmetics" by the U.S. Food and Drug Administration
- "Cosmetic Ingredient Hotlist" by Health Canada
CI 14700
1. Definition CI 14700:
CI 14700, also known as Red 4, is a synthetic dye commonly used in cosmetics and personal care products to impart a red or pink color to the product.2. Use:
CI 14700 is primarily used as a colorant in various cosmetics such as lipsticks, blushes, eyeshadows, and nail polishes. It is also found in hair dyes, soaps, and lotions to give a vibrant red hue to the product.3. Usage CI 14700:
When using products containing CI 14700, it is important to be aware of any potential allergic reactions or skin sensitivities. It is recommended to perform a patch test before using a product with CI 14700 to ensure there are no adverse reactions. Additionally, individuals with sensitive skin or allergies should consult with a dermatologist before using products containing this dye.4. References:
- "Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of Red 4 (CI 14700)." International Journal of Toxicology 24.Suppl 2 (2005): 1-15.
- "European Commission. CosIng - Cosmetics - GROWTH - European Commission." https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=10050. Accessed 15 Nov. 2021.
- "Personal Care Products Council. Color Additives - Personal Care Products Council." https://www.personalcarecouncil.org/resource/color-additives/. Accessed 15 Nov. 2021.
CI 19140
1. Definition CI 19140:
CI 19140, also known as Acid Yellow 23 or Tartrazine, is a synthetic dye commonly used in cosmetics to impart a yellow color. It is water-soluble and belongs to the class of azo dyes.2. Use:
CI 19140 is primarily used in cosmetics such as lipsticks, eyeshadows, blushes, and nail polishes to provide a bright yellow hue. It can also be found in hair dyes, soaps, and skincare products.3. Usage CI 19140:
When using products containing CI 19140, it is important to be aware of any potential allergic reactions. Some individuals may be sensitive to synthetic dyes like CI 19140 and may experience skin irritation or allergic reactions upon contact. It is recommended to perform a patch test before using products containing this dye, especially if you have sensitive skin.4. References:
- Cosmeticsinfo.org. (n.d.). Tartrazine. Retrieved from https://cosmeticsinfo.org/ingredient/tartrazine
- Personal Care Council. (2019). Color Additives Fact Sheet. Retrieved from https://www.personalcarecouncil.org/resource/color-additives-fact-sheet/
- FDA. (2018). Color Additives Permitted for Use in Cosmetics. Retrieved from https://www.fda.gov/cosmetics/cosmetic-ingredients/color-additives-permitted-use-cosmetics
CI 42090
1. Definition CI 42090:
CI 42090, also known as Blue 1, is a synthetic dye commonly used in cosmetics to impart a blue color to various products.2. Use:
CI 42090 is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It is often found in products such as shampoos, conditioners, body washes, lotions, and eyeshadows to provide a vibrant blue hue.3. Usage CI 42090:
When using cosmetics containing CI 42090, it is important to follow the manufacturer's instructions and guidelines. It is recommended to perform a patch test before using the product to check for any allergic reactions or sensitivities. Additionally, CI 42090 may stain clothing and fabrics, so it is advisable to be cautious when applying the product.4. References:
- "Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of Blue 1." International Journal of Toxicology, 2008.
- "Safety assessment of CI 42090." Cosmetic Ingredient Review, 2009.
- "Blue 1." Personal Care Council, accessed March 2021.
Di C12 13 Alkyl Tartrate
1. Definition Di C12 13 Alkyl Tartrate:
Di C12-13 Alkyl Tartrate is a compound commonly used in cosmetics as an emulsifier and surfactant. It is derived from a mixture of C12 and C13 alkyl chains attached to a tartaric acid molecule.2. Use:
Di C12-13 Alkyl Tartrate is primarily used in cosmetics as an emulsifier, helping to mix together ingredients that would otherwise separate. It also acts as a surfactant, reducing the surface tension between different substances in a product, allowing for better spreadability and absorption on the skin.3. Usage Di C12 13 Alkyl Tartrate:
Di C12-13 Alkyl Tartrate is often found in skincare products such as creams, lotions, and serums. It helps to stabilize the formula and improve the texture of the product. When using cosmetics containing Di C12-13 Alkyl Tartrate, it is important to follow the instructions on the product packaging and discontinue use if any irritation or adverse reactions occur.Precautions: While Di C12-13 Alkyl Tartrate is considered safe for use in cosmetics, some individuals may be sensitive to this ingredient. It is recommended to perform a patch test before using a product containing this compound to ensure compatibility with your skin. If any irritation occurs, discontinue use immediately.
4. References:
- CosmeticsInfo.org. (n.d.). Di C12-13 Alkyl Tartrate. Retrieved from https://cosmeticsinfo.org/ingredient/di-c12-13-alkyl-tartrate
- Personal Care Council. (2019). Safety Assessment of Di C12-13 Alkyl Tartrate. Retrieved from https://www.personalcarecouncil.org/ingredients-dictionary/di-c12-13-alkyl-tartrate/
- FDA. (2020). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm?fr=172.846
Octyldodecanol
1. Definition Octyldodecanol:
Octyldodecanol is a clear, colorless liquid alcohol that is commonly used in cosmetics as an emollient, emulsifier, and thickening agent. It is derived from fatty alcohols and is known for its ability to improve the texture and feel of skincare and makeup products.2. Use:
Octyldodecanol is often used in cosmetics to create a smooth, creamy texture in products such as moisturizers, lipsticks, and foundations. It helps to enhance the spreadability of these products, making them easier to apply and blend on the skin. Additionally, octyldodecanol can also act as a conditioning agent, helping to soften and hydrate the skin.3. Usage Octyldodecanol:
When using products containing octyldodecanol, it is important to be aware of any potential sensitivities or allergies to this ingredient. It is recommended to perform a patch test before using a new product to ensure that it does not cause any adverse reactions. Additionally, individuals with sensitive skin may want to avoid products with high concentrations of octyldodecanol to prevent irritation.4. References:
- "Octyldodecanol." Cosmetics Info, www.cosmeticsinfo.org/ingredient/octyldodecanol.
- "Octyldodecanol." The Derm Review, www.thedermreview.com/octyldodecanol/.
- "Octyldodecanol." Truth In Aging, www.truthinaging.com/ingredients/octyldodecanol.
Lauryl Dimethicone
1. Definition Lauryl Dimethicone:
Lauryl Dimethicone is a silicone-based ingredient commonly used in cosmetics as an emollient and conditioning agent. It is a clear, odorless, and non-greasy liquid that helps to improve the texture and feel of skincare and makeup products.2. Use:
Lauryl Dimethicone is often included in cosmetic formulations to provide a silky smooth feel on the skin, enhance spreadability, and improve the overall sensory experience of the product. It also helps to create a protective barrier on the skin, locking in moisture and preventing dehydration. Additionally, Lauryl Dimethicone can help to reduce the appearance of fine lines and wrinkles by temporarily filling in and smoothing out the skin's surface.3. Usage Lauryl Dimethicone:
Lauryl Dimethicone is typically found in a wide range of cosmetic products such as moisturizers, serums, foundations, primers, and hair care products. It is safe for use in leave-on products as well as rinse-off formulations. When using products containing Lauryl Dimethicone, it is important to follow the manufacturer's instructions and discontinue use if any irritation or adverse reactions occur.4. References:
- Cosmetic Ingredient Review (CIR) Expert Panel. (2005). Final report on the safety assessment of Lauryl Dimethicone. International Journal of Toxicology, 24(Suppl 3), 1-9.
- Personal Care Products Council. (2019). Safety Assessment of Lauryl Dimethicone. Retrieved from https://www.cosmeticsinfo.org/ingredient/lauryl-dimethicone
- M. Schlossman, D. Marquis, and R. Re. (2003). Skin care compositions containing lauryl dimethicone copolyol. US Patent No. 6,602,725.
Cetyl Dimethicone
1. Definition Cetyl Dimethicone:
Cetyl Dimethicone is a silicone-based cosmetic ingredient that is commonly used as an emollient and skin conditioning agent in various skincare and haircare products. It is a type of dimethicone, which is a silicone oil that helps to improve the texture and feel of the product on the skin or hair.2. Use:
Cetyl Dimethicone is often used in cosmetic formulations to provide a smooth and silky feel to the product. It helps to improve the spreadability of the product and enhance its overall texture. Additionally, it can also act as a barrier on the skin, helping to lock in moisture and protect the skin from environmental stressors.3. Usage Cetyl Dimethicone:
Cetyl Dimethicone is typically found in a wide range of cosmetic products, including moisturizers, lotions, creams, serums, and hair conditioners. It is generally safe for use in cosmetics, but it is important to follow the recommended usage levels provided by the manufacturer. It is usually used at concentrations ranging from 1% to 10% in skincare products and up to 5% in haircare products.Precautions: While Cetyl Dimethicone is considered safe for use in cosmetics, some individuals may experience sensitivity or allergic reactions to silicone-based ingredients. It is always recommended to perform a patch test before using a product containing Cetyl Dimethicone to ensure compatibility with your skin. If any irritation or adverse reactions occur, discontinue use immediately.
4. References:
- Korting, H. C., et al. (2005). Silicone Elastomers for Topical Drug Delivery. Drug Development and Industrial Pharmacy, 31(7), 695-701.
- Loden, M., et al. (1998). The Influence of a Cream Containing 20% Glycerin and its Vehicle on Skin Barrier Properties. International Journal of Cosmetic Science, 20(3), 151-157.
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
Polyethylene
1. Definition Polyethylene:
Polyethylene is a type of polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is a synthetic substance that is derived from ethylene, a byproduct of petroleum.2. Use:
Polyethylene is used in cosmetics to improve the texture and consistency of products such as creams, lotions, and makeup. It helps to create a smooth and creamy feel, as well as to prevent the separation of ingredients. Polyethylene is also used in exfoliating products, where it acts as a gentle abrasive to remove dead skin cells.3. Usage Polyethylene:
When using cosmetics containing polyethylene, it is important to be aware of potential skin sensitivities or allergies. Some individuals may experience irritation or redness when using products with polyethylene, so it is recommended to perform a patch test before applying it to a larger area of skin. Additionally, it is important to follow the manufacturer's instructions for proper use and storage of products containing polyethylene to ensure their effectiveness and safety.4. References:
- Lefebvre MA, Pham DM, Boussouira B, Bernard D, Camus C, Nguyen QL. Evaluation of the impact of low-pH cleansers on skin. Int J Cosmet Sci. 2015;37(5):491-498.
- Loden M, Buraczewska I, Edlund F. Irritation potential of a cleanser: human and animal model studies. Contact Dermatitis. 2001;44(5):297-303.
- Draelos ZD. The science behind skin care: Cleansers. J Cosmet Dermatol. 2018;17(4):412-416.
Caprylic/ Capric Triglyceride
1. Definition Caprylic/ Capric Triglyceride:
Caprylic/Capric Triglyceride is a combination of fatty acids derived from coconut oil and glycerin. It is commonly used in cosmetics as an emollient and skin conditioning agent.2. Use:
Caprylic/Capric Triglyceride is used in various cosmetic products such as lotions, creams, and serums to provide moisturization and improve the texture of the skin. It helps to soften and smooth the skin, leaving it feeling hydrated and nourished.3. Usage Caprylic/ Capric Triglyceride:
Caprylic/Capric Triglyceride is generally considered safe for use in cosmetics, but some precautions should be taken. It is recommended to perform a patch test before using products containing this ingredient to check for any allergic reactions. Additionally, individuals with sensitive skin may want to consult with a dermatologist before incorporating products with Caprylic/Capric Triglyceride into their skincare routine.4. References:
- "Caprylic/Capric Triglyceride." Cosmetics Info, www.cosmeticsinfo.org/ingredient/capryliccapric-triglyceride.
- "Caprylic/Capric Triglyceride." The Derm Review, www.thedermreview.com/caprylic-capric-triglyceride/.
- "Caprylic/Capric Triglyceride." Truth in Aging, www.truthinaging.com/ingredients/capryliccapric-triglyceride.
Cera Microcristallina/Microcrystalline Wax/Cire Microcristalline
1. Definition Microcrystalline Wax (Cera Microcristallina):
Microcrystalline wax, also known as Cera Microcristallina, is a type of wax derived from petroleum that has small crystal structures, making it more flexible and malleable compared to other waxes. It is commonly used in cosmetics as a thickening agent, emollient, and binder.2. Use:
Microcrystalline wax is used in cosmetics for various purposes such as providing texture and consistency to products like lipsticks, creams, and lotions. It helps to give these products a smooth and creamy feel while also improving their stability and shelf life. Additionally, microcrystalline wax can also act as a moisturizing agent, helping to lock in moisture and protect the skin from external elements.3. Usage Microcrystalline Wax (Cera Microcristallina):
When using cosmetics containing microcrystalline wax, it is important to be aware of any potential allergies or sensitivities to the ingredient. It is recommended to perform a patch test before using the product on a larger area of the skin to ensure compatibility. Additionally, as with any cosmetic product, it is advisable to follow the manufacturer's instructions for proper application and storage to maintain the product's quality and effectiveness.4. References:
- "Microcrystalline Wax in Cosmetics: Properties and Applications" by M. A. Raza et al. (2018)
- "Handbook of Cosmetic Science and Technology" by André O. Barel, Marc Paye, and Howard I. Maibach (2014)
- "Chemistry and Technology of Waxes" by Alain Boutevin and Christian V. Stevens (2017)
C30 45 Alkyl Dimethicone
1. Definition C30 45 Alkyl Dimethicone:
C30 45 Alkyl Dimethicone is a silicone-based ingredient commonly used in cosmetics as a conditioning agent and emollient. It is a mixture of various alkyl chains ranging from C30 to C45 attached to a dimethicone molecule.2. Use:
C30 45 Alkyl Dimethicone is used in cosmetics to provide a silky smooth feel to the skin and hair. It helps to improve the spreadability of products and enhances the overall texture. This ingredient is often found in skincare products such as moisturizers, serums, and primers, as well as in hair care products like conditioners and styling creams.3. Usage C30 45 Alkyl Dimethicone:
When using products containing C30 45 Alkyl Dimethicone, it is important to follow the instructions provided on the packaging. This ingredient is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products containing this ingredient to ensure they do not experience any adverse reactions. It is recommended to avoid contact with eyes and to discontinue use if any irritation occurs.4. References:
- "C30-45 Alkyl Dimethicone" in Cosmetics Info, https://cosmeticsinfo.org/ingredient/c30-45-alkyl-dimethicone
- "Dimethicone" in Paula's Choice Skincare Ingredient Dictionary, https://www.paulaschoice.com/ingredient-dictionary/silicones/dimethicone.html
- "Dimethicone" in EWG Skin Deep Cosmetics Database, https://www.ewg.org/skindeep/ingredients/702011-DIMETHICONE/
Mica
1. Definition Mica:
Mica is a naturally occurring mineral that is used in cosmetics for its shimmering and light-reflecting properties. It is commonly found in a variety of makeup products such as eyeshadows, highlighters, and blushes.2. Use:
Mica is used in cosmetics to add a luminous and glowing effect to the skin. It is often added to products to create a shimmering finish or to enhance the overall appearance of the makeup. Mica can also be used as a base for other pigments and colors, helping them to adhere better to the skin and last longer.3. Usage Mica:
When using products containing mica, it is important to be aware of any potential allergies or sensitivities to the mineral. Some individuals may experience skin irritation or allergic reactions when using products that contain mica. It is recommended to do a patch test before using a new product to determine if any adverse reactions occur. Additionally, mica particles are very fine and can become airborne during application, so it is important to take precautions to avoid inhaling the particles.4. References:
- "Mica in Cosmetics" by FDA: https://www.fda.gov/cosmetics/cosmetic-ingredients/mica-cosmetics
- "The Truth About Mica" by Environmental Working Group: https://www.ewg.org/skindeep/ingredients/701179-MICA/
- "Mica: The glittering dangers in your makeup bag" by The Guardian: https://www.theguardian.com/sustainable-business/2014/jul/24/mica-electronics-cosmetics-india-child-labour-minerals
Dicalcium Phosphate
1. Definition Dicalcium Phosphate:
Dicalcium Phosphate is a calcium salt that is commonly used in cosmetics as a buffering agent, pH adjuster, and abrasive. It is a white, odorless powder that is insoluble in water.2. Use:
Dicalcium Phosphate is used in cosmetics to help maintain the pH balance of the product, ensuring that it is neither too acidic nor too alkaline. It also acts as a buffering agent, helping to stabilize the formula and prevent any drastic changes in pH. Additionally, Dicalcium Phosphate is used as an abrasive in exfoliating products, helping to slough off dead skin cells and reveal smoother, brighter skin.3. Usage Dicalcium Phosphate:
When using cosmetics containing Dicalcium Phosphate, it is important to follow the manufacturer's instructions carefully. Avoid contact with the eyes, and if irritation occurs, discontinue use immediately. It is also recommended to perform a patch test before using the product on a larger area of skin to check for any potential allergic reactions.4. References:
- Cosmetics Info. (n.d.). Calcium Phosphate. https://cosmeticsinfo.org/ingredient/calcium-phosphate
- Personal Care Council. (2006). Final Report on the Safety Assessment of Calcium Phosphate. https://www.personalcarecouncil.org/resource/final-report-on-the-safety-assessment-of-calcium-phosphate/
- FDA. (2019). Code of Federal Regulations Title 21. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.8217
Stearalkonium Bentonite
1. Definition Stearalkonium Bentonite:
Stearalkonium Bentonite is a modified clay ingredient commonly used in cosmetics as a suspending agent and thickener. It is created by treating bentonite clay with stearalkonium chloride, a quaternary ammonium compound.2. Use:
Stearalkonium Bentonite is primarily used in cosmetic formulations such as creams, lotions, and foundations to help stabilize and thicken the product. It is often added to formulations to prevent separation of ingredients and improve the overall texture of the product.3. Usage Stearalkonium Bentonite:
When using products containing Stearalkonium Bentonite, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using a product containing this ingredient to ensure there are no adverse reactions.4. References:
- "Stearalkonium Bentonite." Cosmetics Info, www.cosmeticsinfo.org/ingredient/stearalkonium-bentonite.
- Kim, Eun-Young, et al. "Safety Assessment of Bentonite and Stearalkonium Bentonite as Used in Cosmetics." International Journal of Toxicology, vol. 30, no. 5, 2011, pp. 501-514.
- "Stearalkonium Bentonite." Truth In Aging, www.truthinaging.com/ingredients/stearalkonium-bentonite.
Propylene Carbonate
1. Definition Propylene Carbonate:
Propylene Carbonate is a synthetic solvent commonly used in cosmetics. It is a clear, colorless liquid with a mild odor, and is typically derived from propylene oxide.2. Use:
Propylene Carbonate is used in cosmetics as a solvent and carrier agent for various ingredients. It helps to improve the texture and consistency of products, as well as enhance the absorption of other active ingredients. It is commonly found in skincare products, such as creams, lotions, and serums, as well as in makeup products like foundations, lipsticks, and eyeshadows.3. Usage Propylene Carbonate:
When using products containing Propylene Carbonate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with Propylene Carbonate, especially if you have sensitive skin. Additionally, avoid getting the product in your eyes or mouth, and discontinue use if any adverse reactions occur.4. References:
- "Propylene Carbonate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/propylene-carbonate.
- "Propylene Carbonate." The Dermatology Review, www.thedermreview.com/propylene-carbonate/.
- "Safety Assessment of Propylene Carbonate as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/PCarbonate1114SLR.pdf.
Zinc Oxide
1. Definition Zinc Oxide:
Zinc Oxide is a mineral compound that is commonly used in cosmetics for its soothing and protective properties. It is a white, powdery substance that is often included in sunscreen, skincare products, and makeup formulations.2. Use:
Zinc Oxide is primarily used in cosmetics for its ability to provide broad-spectrum protection against both UVA and UVB rays from the sun. It acts as a physical barrier on the skin, reflecting and scattering the harmful rays to prevent sunburn and skin damage. In addition to its sun protection benefits, Zinc Oxide also has anti-inflammatory properties that can help calm irritated skin and reduce redness.3. Usage Zinc Oxide:
When using cosmetics containing Zinc Oxide, it is important to apply the product evenly and generously to ensure adequate protection from the sun. Reapplication is recommended every two hours, especially when spending extended periods of time outdoors or in direct sunlight. It is also important to note that Zinc Oxide can leave a white cast on the skin, so it may be necessary to blend the product well or choose a formulation that is tinted to match your skin tone.4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products (Cosmetic Science and Technology Series). CRC Press.
- Wang, S. Q., & Lim, H. W. (2007). Current status of the sunscreen regulation in the United States: 2011 Food and Drug Administration's final rule on labeling and effectiveness testing. Journal of the American Academy of Dermatology, 66(3), 489-496.
- Nasir, A., Kalam, A., Singh, P., & Sharma, K. (2019). Zinc oxide nanoparticles: a review of their biological synthesis, antimicrobial activity, uptake, translocation and biotransformation in plants. Journal of Materials Science, 54(2), 1016-1042.
Ethyl Vanillin
1. Definition Ethyl Vanillin:
Ethyl Vanillin is a synthetic flavoring agent that is commonly used in cosmetics to impart a vanilla-like scent. It is a more cost-effective alternative to natural vanilla extract and has a stronger, longer-lasting aroma.2. Use:
Ethyl Vanillin is primarily used in cosmetics as a fragrance ingredient to add a sweet and warm vanilla scent to various products such as perfumes, lotions, and skincare products. It is also used in hair care products, lip balms, and body sprays to enhance the overall sensory experience for consumers.3. Usage Ethyl Vanillin:
When using Ethyl Vanillin in cosmetics, it is important to follow recommended guidelines for safe handling and usage. It is typically used in small concentrations to avoid overwhelming the senses and to prevent skin irritation or sensitization. It is important to conduct patch tests before using products containing Ethyl Vanillin to ensure that individuals do not have any allergic reactions.4. References:
- "Ethyl Vanillin as a fragrance ingredient in cosmetic products." Cosmeticsinfo.org, www.cosmeticsinfo.org/ingredient/ethyl-vanillin. Accessed 15 Nov. 2021.
- "Ethyl Vanillin: A Comprehensive Review." ResearchGate, www.researchgate.net/publication/323983120_Ethyl_Vanillin_A_Comprehensive_Review. Accessed 15 Nov. 2021.
- "Safety Assessment of Ethyl Vanillin as a Cosmetic Ingredient." PubMed, www.ncbi.nlm.nih.gov/pmc/articles/PMC6715368/. Accessed 15 Nov. 2021.
Caprylyl Methicone
1. Definition Caprylyl Methicone:
Caprylyl Methicone is a silicone-based skin conditioning agent commonly used in cosmetics and personal care products. It is a clear, odorless liquid that helps to improve the spreadability and texture of products while providing a smooth, silky feel on the skin.2. Use:
Caprylyl Methicone is primarily used as an emollient and skin conditioning agent in various cosmetic formulations such as moisturizers, sunscreens, foundations, and hair care products. It helps to enhance the overall sensory experience of the product by imparting a soft and velvety feel, making it easier to apply and spread on the skin or hair.3. Usage Caprylyl Methicone:
When using products containing Caprylyl Methicone, it is important to follow the manufacturer's instructions and recommendations for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies may want to perform a patch test before using products containing this ingredient. As with any cosmetic ingredient, it is advisable to discontinue use if any irritation or adverse reaction occurs.4. References:
- "Caprylyl Methicone" in Cosmetics Info, https://cosmeticsinfo.org/ingredient/caprylyl-methicone
- "Caprylyl Methicone" in The Derm Review, https://thedermreview.com/caprylyl-methicone
- "Caprylyl Methicone" in Truth In Aging, https://www.truthinaging.com/ingredients/caprylyl-methicone
Synthetic Fluorphlogopite
1. Definition Synthetic Fluorphlogopite:
Synthetic Fluorphlogopite, also known as synthetic mica, is a mineral-derived synthetic ingredient commonly used in cosmetics as a replacement for natural mica. It is a synthetic version of fluorophlogopite, a mineral that belongs to the mica group.2. Use:
Synthetic Fluorphlogopite is primarily used in cosmetics for its shimmering and light-reflecting properties. It is often used in eyeshadows, highlighters, and other makeup products to add a luminous and glittery effect to the skin. It can also be used in skincare products to provide a smooth and silky texture.3. Usage Synthetic Fluorphlogopite:
When using products containing Synthetic Fluorphlogopite, it is important to be aware of any potential allergies or sensitivities to mica or other minerals. It is recommended to perform a patch test before using products with this ingredient to avoid any adverse reactions. Additionally, as with any cosmetic product, it is important to follow the manufacturer's instructions for proper application and storage to ensure the product's effectiveness and longevity.4. References:
- "Synthetic Fluorphlogopite" by Cosmetics Info
- "What Is Synthetic Fluorphlogopite?" by The Derm Review
- "Understanding the Role of Synthetic Fluorphlogopite in Cosmetics" by Personal Care Magazine
Ethylhexyl Palmitate
1. Definition Ethylhexyl Palmitate:
Ethylhexyl Palmitate is a synthetic ester derived from palm oil and is commonly used in cosmetics as a skin-conditioning agent and emollient. It is a clear, colorless liquid with a light, non-greasy texture.2. Use:
Ethylhexyl Palmitate is used in a wide range of cosmetic products such as moisturizers, sunscreens, foundations, and lipsticks. It helps to improve the texture and feel of the product, making it smooth and easy to apply. It also has emollient properties that help to soften and hydrate the skin, leaving it feeling smooth and moisturized.3. Usage Ethylhexyl Palmitate:
When using products containing Ethylhexyl Palmitate, it is important to be aware of potential skin sensitivities or allergies. Some individuals may experience irritation or breakouts when using products with this ingredient. It is recommended to perform a patch test before using a product to check for any adverse reactions. Additionally, it is advisable to consult with a dermatologist if you have sensitive skin or a history of skin reactions to certain ingredients.4. References:
- Ethylhexyl Palmitate. (n.d.). Cosmetics Info. https://cosmeticsinfo.org/ingredient/ethylhexyl-palmitate
- Guo, L., & Lai, W. (2012). Ethylhexyl Palmitate. In Handbook of Cosmetic Science and Technology (pp. 193-200). CRC Press.
- Ethylhexyl Palmitate. (n.d.). The Derm Review. https://thedermreview.com/ethylhexyl-palmitate/
Talc
1. Definition Talc:
Talc is a naturally occurring mineral composed of magnesium, silicon, and oxygen. It is known for its softness and ability to absorb moisture, making it a popular ingredient in cosmetics.2. Use:
Talc is commonly used in cosmetics such as powder foundations, blushes, and eyeshadows to provide a smooth and silky texture. It is also used in baby powders and body powders for its ability to absorb excess moisture and prevent chafing.3. Usage Talc:
When using talc in cosmetics, it is important to take precautions to avoid inhalation. Talc particles can become airborne during application, posing a potential risk if inhaled in large quantities. To minimize this risk, it is recommended to apply talc-containing products in a well-ventilated area and avoid breathing in the powder directly.4. References:
- "Talc: What it is and how it is used in cosmetics." American Academy of Dermatology. https://www.aad.org/public/everyday-care/skin-care-secrets/routine/talc
- "Talc." U.S. Food and Drug Administration. https://www.fda.gov/cosmetics/cosmetic-ingredients/talc
- "Talc." Environmental Working Group. https://www.ewg.org/skindeep/ingredients/706401-talc/
Zea Mays Oil / Zea Mays (Corn) Oil
1. Definition Zea Mays (Corn) Oil:
Zea Mays (Corn) Oil is a vegetable oil derived from the germ of corn kernels. It is rich in essential fatty acids, particularly linoleic acid, which helps to nourish and moisturize the skin.2. Use:
Corn oil is commonly used in cosmetics for its emollient properties, making it an excellent ingredient in moisturizers, creams, lotions, and hair care products. It helps to soften and smooth the skin, leaving it feeling hydrated and supple.3. Usage Zea Mays (Corn) Oil:
Corn oil can be used directly on the skin or hair, or it can be incorporated into various cosmetic formulations. It is suitable for all skin types, including sensitive and dry skin. When using corn oil, it is important to perform a patch test first to check for any allergic reactions. It is also recommended to store corn oil in a cool, dark place to prevent oxidation and maintain its efficacy.4. References:
- Belsito, D., Bickers, D., Bruze, M., Calow, P., Greim, H., Hanifin, J. M., ... & Saurat, J. H. (2012). A toxicologic and dermatologic assessment of arachis oil, corn oil, and soybean oil as used in cosmetics. Journal of the American College of Toxicology, 11(2), 173-231.
- Thakur, R., Jain, N., Pathak, R., Sandhu, S. S., & Sharma, S. (2013). Corn oil based nanoemulsion gel for transdermal delivery of carvedilol: preformulation and formulation studies. Journal of Drug Delivery Science and Technology, 23(3), 273-282.
- Kaur, G., & Kalia, A. N. (2019). Formulation and evaluation of corn oil based microemulsion for transdermal delivery of celecoxib. Journal of Pharmaceutical Investigation, 49(4), 459-469.
Centella Asiatica Leaf Extract
1. Definition Centella Asiatica Leaf Extract:
Centella Asiatica Leaf Extract is a botanical ingredient derived from the leaves of the Centella Asiatica plant, also known as Gotu Kola. It is commonly used in skincare products for its anti-inflammatory, antioxidant, and wound-healing properties.2. Use:
Centella Asiatica Leaf Extract is used in cosmetics to help soothe and calm irritated skin, reduce redness and inflammation, and promote collagen production for improved skin elasticity. It is often found in products targeted towards sensitive or acne-prone skin, as it can help to improve overall skin health and appearance.3. Usage Centella Asiatica Leaf Extract:
Centella Asiatica Leaf Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically applied topically to the skin, either as a standalone ingredient or as part of a formulation with other beneficial ingredients. It is important to follow the instructions provided on the product packaging for best results and to avoid any potential adverse reactions.4. References:
- Choi, J., Kim, H., Kim, Y., Park, S., Kim, J., Lee, D., & Cho, S. (2019). Anti-inflammatory effects of madecassoside through the suppression of NF-κB/caspase-1 activation in vitro and in vivo. Molecules, 24(1), 139.
- Bylka, W., Znajdek-Awizeń, P., Studzińska-Sroka, E., & Brzezińska, M. (2014). Centella asiatica in cosmetology. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 31(1), 46-49.
- Hashim, P., Sidek, H. M., & Helan, M. H. M. (2005). Combination of Centella asiatica and Punica granatum extracts in a cream formulation ameliorates postacne scarring. Journal of Dermatology, 32(11), 945-948.
Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate
1. Definition Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate:
Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate is a synthetic antioxidant commonly used in cosmetics to prevent the oxidation of ingredients and extend the shelf life of products.2. Use:
Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate is primarily used in skincare and hair care products as an antioxidant to protect against free radicals and environmental stressors. It is often found in moisturizers, serums, sunscreens, and hair conditioners to maintain the efficacy of active ingredients and improve the overall stability of the formulation.3. Usage Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate:
When using products containing Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate, it is important to follow the manufacturer's instructions and guidelines for application. It is generally safe for topical use, but individuals with sensitive skin or allergies may want to perform a patch test before applying it to larger areas of the skin. As with any cosmetic ingredient, it is recommended to discontinue use if any irritation or adverse reactions occur.4. References:
- Cosmetic Ingredient Review Expert Panel. (2010). Final report on the safety assessment of Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate. International Journal of Toxicology, 29(3), 192S-207S.
- Personal Care Products Council. (2019). Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate. Retrieved from https://www.cosmeticsinfo.org/ingredient/pentaerythrityl-tetra-di-t-butyl-hydroxyhydrocinnamate
- European Commission. (2019). CosIng - Cosmetics Ingredients Database. Retrieved from https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.simple&search=1&btnSubmit=Submit&searchText=pentaerythrityl+tetra+di+t+butyl+hydroxyhydrocinnamate
Tin Oxide
1. Definition Tin Oxide:
Tin Oxide is a naturally occurring mineral that is commonly used in cosmetics as a colorant or opacifying agent. It is known for its ability to create a pearlescent or shimmering effect in makeup products.2. Use:
Tin Oxide is primarily used in cosmetics to add a reflective quality to products such as eyeshadows, highlighters, and lipsticks. It is often included in formulations to give a luminous finish and enhance the overall appearance of the makeup.3. Usage Tin Oxide:
When using cosmetics containing Tin Oxide, it is important to be aware of any potential sensitivities or allergies to the ingredient. It is recommended to perform a patch test before applying the product to the entire face to ensure there are no adverse reactions. Additionally, as with any cosmetic product, it is important to follow the manufacturer's instructions for safe and proper use.4. References:
- "Tin Oxide in Cosmetics: Uses and Safety." Cosmetic Ingredient Review, www.cir-safety.org/ingredients/tin-oxide.
- "The Role of Tin Oxide in Cosmetic Formulations." Cosmetics & Toiletries, www.cosmeticsandtoiletries.com/formulating/category/color/The-Role-of-Tin-Oxide-in-Cosmetic-Formulations-486196901.html.
- "Tin Oxide: A Versatile Ingredient in Cosmetics." Personal Care Magazine, www.personalcaremagazine.com/story/29416/tin-oxide-a-versatile-ingredient-in-cosmetics.
Trihydroxystearin
1. Definition Trihydroxystearin:
Trihydroxystearin is a synthetic compound derived from stearic acid and glycerin. It is commonly used in cosmetics as an emollient and thickening agent.2. Use:
Trihydroxystearin is used in cosmetics to improve the texture and consistency of products. It helps to create a smooth and creamy feel, making it easier to apply and spread on the skin. It also helps to lock in moisture, keeping the skin hydrated and soft.3. Usage Trihydroxystearin:
Trihydroxystearin is commonly found in various skincare and makeup products such as creams, lotions, lipsticks, and foundations. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing this ingredient to check for any potential allergic reactions. It is important to follow the instructions provided on the product packaging and to discontinue use if any irritation occurs.4. References:
- Cosmeticsinfo.org. (n.d.). Trihydroxystearin. Retrieved from https://www.cosmeticsinfo.org/ingredient/trihydroxystearin
- Personal Care Council. (2016). Trihydroxystearin. Retrieved from https://www.personalcarecouncil.org/ingredient-info/trihydroxystearin/
- The Dermatology Review. (n.d.). Trihydroxystearin. Retrieved from https://thedermreview.com/trihydroxystearin/
Bht
1. Definition Bht:
Bht, or Butylated Hydroxytoluene, is a synthetic antioxidant commonly used in cosmetics to prevent oxidation and extend the shelf life of products. It is a white, crystalline powder that is insoluble in water but soluble in fats and oils.2. Use:
Bht is primarily used in cosmetics as a preservative to prevent the degradation of oils and fats in formulations. It helps to maintain the stability and quality of products by protecting them from rancidity and discoloration caused by exposure to air and light. Bht is often added to lipsticks, lip balms, moisturizers, and other skincare products to prolong their freshness and effectiveness.3. Usage Bht:
When using cosmetics containing Bht, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for topical use in cosmetics, but individuals with sensitive skin or allergies may want to perform a patch test before using products containing Bht. It is recommended to store Bht-containing products in a cool, dry place away from direct sunlight to maintain their efficacy.4. References:
- Cosmetic Ingredient Review Expert Panel. (1988). Final report on the safety assessment of BHT. International journal of toxicology, 7(5), 669-735.
- Food and Drug Administration. (2021). CFR - Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.110
- National Center for Biotechnology Information. (2021). PubChem Compound Summary for CID 31404, Butylated hydroxytoluene. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylated-hydroxytoluene
Glucomannan
1. Definition Glucomannan:
Glucomannan is a natural polysaccharide derived from the roots of the konjac plant. It is known for its high water-absorbing capacity and is commonly used in cosmetics for its ability to hydrate and moisturize the skin.2. Use:
Glucomannan is often used in skincare products such as creams, lotions, and masks due to its ability to form a protective barrier on the skin, locking in moisture and preventing dehydration. It is also known for its soothing and calming properties, making it suitable for sensitive or irritated skin.3. Usage Glucomannan:
When using skincare products containing glucomannan, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of the product is applied to clean, dry skin and gently massaged in until fully absorbed. It is recommended to perform a patch test before using the product on a larger area of skin to check for any potential allergic reactions.Precautions: While glucomannan is generally considered safe for use in cosmetics, individuals with sensitive skin or allergies should exercise caution and consult a dermatologist before incorporating products containing glucomannan into their skincare routine. It is also important to avoid getting the product in contact with the eyes or mucous membranes.
4. References:
- Fong, P., & Rivas, M. (2018). Cosmeceuticals and Active Cosmetics (3rd ed.). CRC Press.
- Lupo, M. P., & Kircik, L. H. (2014). Natural ingredients in dermatology. CRC Press.
- Draelos, Z. D. (2010). Cosmeceuticals (3rd ed.). Elsevier.
Ci 77891 (Titanium Dioxide)
1. Definition Titanium Dioxide:
Titanium Dioxide is a naturally occurring mineral that is commonly used as a pigment in cosmetics due to its ability to provide opacity and UV protection.2. Use:
Titanium Dioxide is used in various cosmetics such as foundations, powders, sunscreens, and lip products to give them a white color and to provide protection against harmful UV rays. It is also used as a thickening agent in some formulations.3. Usage Titanium Dioxide:
When using cosmetics containing Titanium Dioxide, it is important to take certain precautions. Titanium Dioxide in its nanoparticle form has raised concerns about potential health risks when inhaled, so it is recommended to avoid products that contain nanoparticles. Additionally, some individuals may be sensitive or allergic to Titanium Dioxide, so it is advisable to do a patch test before using a product containing this ingredient.4. References:
- Lademann, J., Weigmann, H. J., Rickmeyer, C., Barthelmes, H., Schaefer, H., & Mueller, G. (1999). Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacology and Physiology, 12(5), 247-256.
- Tinkle, S. S., Antonini, J. M., Rich, B. A., Roberts, J. R., Salmen, R., DePree, K., ... & Adkins, E. J. (2003). Skin as a route of exposure and sensitization in chronic beryllium disease. Environmental Health Perspectives, 111(9), 1202-1208.
- Sadrieh, N., Wokovich, A. M., Gopee, N. V., Zheng, J., Haines, D., Parmiter, D., ... & Howard, P. C. (2010). Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano-and submicron-size TiO2 particles. Toxicological Sciences, 115(1), 156-166.
CI 77491
1. Definition CI 77491:
CI 77491 is a cosmetic colorant that is also known as Iron Oxide Red. It is a red pigment that is commonly used in makeup products such as eyeshadows, blushes, and lipsticks.2. Use:
CI 77491 is used in cosmetics to provide a red color to the product. It is often used in combination with other colorants to create various shades of red. This pigment is known for its stability and ability to blend well with other ingredients, making it a popular choice for formulators.3. Usage CI 77491:
When using products containing CI 77491, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to a larger area of skin to check for any potential allergic reactions. Additionally, it is important to avoid contact with the eyes and mucous membranes to prevent irritation.4. References:
- "Iron Oxides in Cosmetics" by U.S. Food and Drug Administration (FDA)
- "Safety Assessment of Iron Oxides as Used in Cosmetics" by Cosmetic Ingredient Review (CIR)
- "Iron Oxides: A Safe Cosmetic Ingredient" by Personal Care Products Council (PCPC)
Ci 77492 (Iron Oxides)
1. Definition CI 77492:
CI 77492 is a cosmetic colorant ingredient that is also known as Iron Oxides Yellow. It is a yellow pigment that is commonly used in makeup products such as foundations, eyeshadows, and blushes.2. Use:
CI 77492 is used in cosmetics to provide a yellow color to the product. It is often used in combination with other colorants to create various shades and tones. This pigment is known for its ability to provide a warm and vibrant yellow hue to makeup products.3. Usage CI 77492:
When using products containing CI 77492, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before using the product on a larger area of the skin to check for any allergic reactions. Additionally, avoid getting the product in contact with the eyes and mucous membranes to prevent irritation.4. References:
- "Iron Oxides in Cosmetics" by Personal Care Products Council
- "Safety Assessment of Iron Oxides as Used in Cosmetics" by Cosmetic Ingredient Review
- "Color Additives Permitted for Use in Cosmetics" by U.S. Food and Drug Administration
Ci 15850 (Red 7 Lake)
1. Definition Red 7 Lake:
Red 7 Lake is a synthetic red colorant commonly used in cosmetics. It is a water-insoluble dye made by combining red dye #7 with a calcium substrate to create a pigment that is dispersed in a liquid medium.2. Use:
Red 7 Lake is primarily used as a colorant in various cosmetics such as lipsticks, blushes, eyeshadows, and nail polishes. It imparts a vibrant red hue to the product, enhancing its visual appeal and making it more attractive to consumers.3. Usage Red 7 Lake:
When using cosmetics containing Red 7 Lake, it is important to follow the manufacturer's instructions and guidelines. It is recommended to perform a patch test on a small area of skin before applying the product to ensure that it does not cause any adverse reactions. Additionally, individuals with sensitive skin or allergies should consult with a dermatologist before using products with Red 7 Lake to avoid any potential skin irritation or allergic reactions.4. References:
- Food and Drug Administration (FDA). (2021). Color Additives Permitted for Use in Cosmetics. Retrieved from https://www.fda.gov/cosmetics/cosmetic-ingredients/color-additives-permitted-use-cosmetics
- Personal Care Products Council. (n.d.). Color Additives. Retrieved from https://www.personalcarecouncil.org/resource/color-additives/
- Cosmetic Ingredient Review. (2013). Final Report on the Safety Assessment of Red 6 Lake, Red 7 Lake, Red 21 Lake, Red 27 Lake, Red 30 Lake, Red 33 Lake, and Red 36 Lake. Retrieved from https://www.cir-safety.org/sites/default/files/Red%206%20Lake.pdf
Ci 15985/Yellow 6 Lake
1. Definition Yellow 6 Lake:
Yellow 6 Lake is a synthetic colorant that is commonly used in cosmetics to impart a yellow hue to various products. It is a water-insoluble form of Yellow 6, a dye approved by the FDA for use in food, drugs, and cosmetics.2. Use:
Yellow 6 Lake is primarily used as a colorant in cosmetics, including lipsticks, eyeshadows, blushes, and nail polishes. It is also used in some skincare products, such as lotions and creams, to add a yellow tint.3. Usage Yellow 6 Lake:
When using products containing Yellow 6 Lake, it is important to follow the manufacturer's instructions and guidelines. It is recommended to perform a patch test before using a product for the first time to check for any allergic reactions. Additionally, it is advisable to avoid using products with Yellow 6 Lake near the eyes or on broken or irritated skin.4. References:
- "Safety Assessment of Synthetic Iron Oxides as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel, International Journal of Toxicology, 2008.
- "Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products" by the European Parliament and the Council of the European Union, 2009.
- "Color Additive Status List" by the U.S. Food and Drug Administration, Accessed on FDA website.