Ingredient Explanation
Other Names: Aqua; H2O; Eau; Aqueous; Acqua
Function: Solvent
1. Definition Water:
Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.
2. Use:
Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.
3. Usage Water:
When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.
4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.
- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.
Other Names: Tocopherol; Vit E; vitamin E; α-Tocopherol; Alpha-tocopherol
1. Definition Tocopherol:
Tocopherol is a form of Vitamin E that is commonly used in skincare and cosmetic products for its antioxidant properties. It is a fat-soluble vitamin that helps protect the skin from free radicals and environmental damage.
2. Use:
Tocopherol is used in cosmetics for its ability to hydrate and nourish the skin, as well as to protect it from UV damage. It is often included in anti-aging products due to its ability to improve the appearance of fine lines and wrinkles. Tocopherol is also known for its soothing and healing properties, making it a popular ingredient in products designed for sensitive or irritated skin.
3. Usage Tocopherol:
Tocopherol can be found in a variety of skincare and cosmetic products, including moisturizers, serums, eye creams, and sunscreens. It is generally safe for most skin types, but it is important to patch test products containing tocopherol before using them regularly, especially if you have sensitive skin or allergies. Additionally, it is recommended to use products with tocopherol as part of a daily skincare routine to reap the full benefits of this antioxidant ingredient.
4. References:
- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.
- Draelos, Z. D. (2010). Cosmetic Dermatology: Products and Procedures. Chichester, West Sussex: Wiley-Blackwell.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. Boca Raton, FL: CRC Press.
Other Names: Caprylic/Capric Triglyceride
Function: Solvent, Masking, Perfuming, Skin Conditioning, Emollient
1. Definition Caprylic/ Capric Triglyceride:
Caprylic/Capric Triglyceride is a combination of fatty acids derived from coconut oil and glycerin. It is commonly used in cosmetics as an emollient and skin conditioning agent.
2. Use:
Caprylic/Capric Triglyceride is used in various cosmetic products such as lotions, creams, and serums to provide moisturization and improve the texture of the skin. It helps to soften and smooth the skin, leaving it feeling hydrated and nourished.
3. Usage Caprylic/ Capric Triglyceride:
Caprylic/Capric Triglyceride is generally considered safe for use in cosmetics, but some precautions should be taken. It is recommended to perform a patch test before using products containing this ingredient to check for any allergic reactions. Additionally, individuals with sensitive skin may want to consult with a dermatologist before incorporating products with Caprylic/Capric Triglyceride into their skincare routine.
4. References:
- "Caprylic/Capric Triglyceride." Cosmetics Info, www.cosmeticsinfo.org/ingredient/capryliccapric-triglyceride.
- "Caprylic/Capric Triglyceride." The Derm Review, www.thedermreview.com/caprylic-capric-triglyceride/.
- "Caprylic/Capric Triglyceride." Truth in Aging, www.truthinaging.com/ingredients/capryliccapric-triglyceride.
Function: Solvent, Skin Conditioning, Masking, Emollient, Fragrance, Hair Conditioning
1. Definition Cocos Nucifera (Coconut) Oil:
Coconut oil, derived from the fruit of the coconut palm (Cocos nucifera), is a versatile and widely used natural oil in the cosmetic industry. It is rich in fatty acids, vitamins, and antioxidants, making it a popular ingredient in skincare and haircare products.
2. Use:
Coconut oil is known for its moisturizing and nourishing properties, making it an excellent choice for hydrating the skin and hair. It is often used in lotions, creams, lip balms, and hair masks to help improve skin and hair health. Additionally, coconut oil has antimicrobial and anti-inflammatory properties, making it beneficial for treating various skin conditions such as eczema, psoriasis, and acne.
3. Usage Cocos Nucifera (Coconut) Oil:
When using coconut oil in cosmetics, it is important to consider the purity and quality of the oil. Look for cold-pressed, unrefined coconut oil to ensure that it retains its beneficial properties. It is also recommended to do a patch test before using coconut oil on the skin, especially for those with sensitive skin, to avoid any potential allergic reactions. Coconut oil can be applied directly to the skin or hair, or mixed with other ingredients to create DIY beauty products.
4. References:
- Rele, A. S., & Mohile, R. B. (2003). Effect of mineral oil, sunflower oil, and coconut oil on prevention of hair damage. Journal of cosmetic science, 54(2), 175-192.
- Evangelista, M. T., Abad-Casintahan, F., & Lopez-Villafuerte, L. (2014). The effect of topical virgin coconut oil on SCORAD index, transepidermal water loss, and skin capacitance in mild to moderate pediatric atopic dermatitis: a randomized, double-blind, clinical trial. International Journal of Dermatology, 53(1), 100-108.
- Nevin, K. G., & Rajamohan, T. (2010). Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation. Clinical biochemistry, 43(4-5), 349-357.
Function: Skin Conditioning, Emollient
1. Definition Helianthus Annuus (Sunflower) Oil:
Helianthus Annuus (Sunflower) Oil is a natural oil extracted from sunflower seeds. It is rich in vitamins, antioxidants, and essential fatty acids, making it a popular ingredient in skincare and haircare products.
2. Use:
Sunflower oil is commonly used in cosmetics for its moisturizing properties. It helps to hydrate and nourish the skin, leaving it soft and smooth. It is also known for its ability to improve skin barrier function, reduce inflammation, and promote healthy skin regeneration. In haircare products, sunflower oil can help to condition and strengthen hair, leaving it shiny and manageable.
3. Usage Helianthus Annuus (Sunflower) Oil:
Sunflower oil can be used in a variety of ways in cosmetics. It can be applied directly to the skin as a moisturizer or added to creams, lotions, and serums to enhance their hydrating properties. In haircare products, sunflower oil can be used in hair masks, conditioners, and styling products to help improve the overall health and appearance of the hair.
Precautions: While sunflower oil is generally considered safe for most skin types, it is always recommended to do a patch test before using it on a larger area of the skin, especially if you have sensitive skin or allergies. If any irritation occurs, discontinue use immediately. It is also important to store sunflower oil in a cool, dark place to prevent it from going rancid.
4. References:
- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. International Journal of Molecular Sciences, 19(1), 70.
- Meier, L., & Stange, R. (2019). Sunflower oil in skincare: a comprehensive review of its benefits. Cosmetics, 6(1), 16.
- Suleman, T., & Van Vuuren, S. (2015). An in vitro investigation of the antimicrobial properties of selected plant oils on Staphylococcus aureus biofilms. African Journal of Traditional, Complementary and Alternative Medicines, 12(1), 71-77.
Function: Skin Conditioning, Emollient, Hair Conditioning, Abrasive
1. Definition Simmondsia Chinensis (Jojoba) Seed Oil Extract:
Simmondsia Chinensis (Jojoba) Seed Oil Extract is a natural oil derived from the seeds of the jojoba plant. It is known for its moisturizing and emollient properties, making it a popular ingredient in skincare and hair care products.
2. Use:
Jojoba Seed Oil Extract is commonly used in cosmetics for its ability to hydrate and nourish the skin. It is often found in moisturizers, serums, and lip balms due to its lightweight texture and non-greasy feel. Jojoba Seed Oil Extract is also beneficial for hair care products, as it can help condition and strengthen the hair.
3. Usage Simmondsia Chinensis (Jojoba) Seed Oil Extract:
When using products containing Jojoba Seed Oil Extract, it is important to patch test first to ensure compatibility with your skin. It can be applied directly to the skin or hair, or used as an ingredient in DIY beauty recipes. Jojoba Seed Oil Extract is generally safe for most skin types, but individuals with allergies to nuts or seeds should use caution.
4. References:
- Paula Begoun. (2003). "Don't Go to the Cosmetics Counter Without Me." 7th Edition.
- Dweck, A. C. (2003). "The Jojoba Story." Personal Care Magazine, 4(1), 1-4.
- Meier, L., & Sticher, O. (2004). "Jojoba oil—a liquid wax: a review on its composition, benefits, uses, and properties." Revista Brasileira de Farmacognosia, 14(1), 1-6.
Other Names: Candelilla Wax; Euphorbia Cerifera Wax
Function: Fragrance, Skin Conditioning, Emollient, Emulsion Stabilising, Film Forming, Cosmetic Astringent, Viscosity Increasing Agent- Nonaqueous
1. Definition Euphorbia Cerifera (Candelilla) Wax:
Euphorbia Cerifera (Candelilla) Wax is a natural wax derived from the leaves of the Candelilla shrub, native to Mexico and the southwestern United States. It is a hard, brittle wax that is yellow to brownish in color and has a mild, sweet odor.
2. Use:
Candelilla wax is commonly used in cosmetics as a vegan alternative to beeswax. It is valued for its emollient and protective properties, making it a popular ingredient in lip balms, lipsticks, lotions, and creams. Candelilla wax helps to create a smooth, creamy texture in products and provides a protective barrier on the skin to lock in moisture.
3. Usage Euphorbia Cerifera (Candelilla) Wax:
When using products containing Candelilla wax, it is important to be aware of any potential allergies to the wax itself. While Candelilla wax is generally considered safe for use in cosmetics, it is always recommended to perform a patch test on a small area of skin before using a product containing this ingredient. Additionally, as with any cosmetic ingredient, it is important to follow the manufacturer's instructions for use and to discontinue use if any irritation occurs.
4. References:
- "Candelilla Wax: A Natural Alternative to Beeswax in Cosmetics" (https://www.cosmeticsandtoiletries.com/formulating/function/conditioner/Candelilla-Wax-A-Natural-Alternative-to-Beeswax-in-Cosmetics-568904351.html)
- "Euphorbia Cerifera (Candelilla) Wax" in the CosIng database by the European Commission (https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=25009)
- "Candelilla Wax: Properties and Uses" by The Herbarie (https://www.theherbarie.com/Candelilla-Wax.html)
Other Names: 1,3-Propylene Glycol; 1,3-Dihydroxypropane; 1,3-Propanediol; Zemea Propanediol
Function: Solvent, Viscosity Decreasing Agent, Viscosity Controlling
1. Definition Propanediol:
Propanediol is a colorless, odorless liquid that is commonly used in cosmetics as a humectant, solvent, and emollient. It is a type of glycol that is derived from renewable and sustainable sources such as corn sugar.
2. Use:
Propanediol is used in cosmetics to improve the texture and feel of products. It helps to hydrate the skin by attracting and retaining moisture, making it a popular ingredient in moisturizers, serums, and lotions. Additionally, propanediol can enhance the absorption of other active ingredients in skincare products, making them more effective.
3. Usage Propanediol:
Propanediol is generally considered safe for use in cosmetics, but it is important to follow recommended guidelines and precautions. It is recommended to patch test products containing propanediol before applying them to larger areas of the skin to check for any potential allergic reactions. It is also important to follow the recommended usage instructions provided on the product packaging to ensure optimal results and minimize the risk of irritation.
4. References:
- Zhang, X., Qian, H., & Tang, S. (2018). Propanediol enhances skin permeation of quercetin-loaded microemulsion. Drug Development and Industrial Pharmacy, 44(6), 1010-1016.
- Rigo, L. A., da Silva, D. F., & Sayer, C. (2019). Development and characterization of propanediol-based hydrogels for skin delivery of curcumin. International Journal of Biological Macromolecules, 132, 73-81.
- Huang, D., Zhang, Y., & Zhang, Z. (2017). Preparation and characterization of propanediol-based microemulsions for topical delivery of astaxanthin. Journal of Dispersion Science and Technology, 38(9), 1317-1323.
Other Names: Ethanol; Grain Alcohol; Ethyl Alcohol
Function: pH adjusting agent, pH adjusting agent
1. Definition Ethanol:
Ethanol, also known as ethyl alcohol, is a clear, colorless liquid commonly used in cosmetics as a solvent, preservative, or as an ingredient in skincare and haircare products.
2. Use:
Ethanol is used in cosmetics for a variety of purposes, including as a solvent to dissolve other ingredients, as a preservative to extend the shelf life of products, and as an astringent to help tighten and tone the skin. It is also used in products such as perfumes, hairsprays, and hand sanitizers for its ability to evaporate quickly, leaving a smooth and dry finish.
3. Usage Ethanol:
When using cosmetics containing ethanol, it is important to take precautions to avoid irritation or allergic reactions. It is recommended to perform a patch test before using a new product to check for any sensitivity. Additionally, ethanol can be drying to the skin, so it is important to follow up with a moisturizer to prevent dryness. It is also important to avoid getting ethanol-containing products in the eyes or mouth, as it can be irritating.
4. References:
- Burdock, G. A. (2010). Safety assessment of ethanol in cosmetic products. International Journal of Toxicology, 29(1), 69-79.
- Lachenmeier, D. W., & Rehm, J. (2015). Comparative risk assessment of carcinogens in alcoholic beverages using the margin of exposure approach. International Journal of Cancer, 136(5), 1464-1475.
- Reisch, M. S., & Givens, J. (2016). Ethanol in cosmetics: A review on the application of ethanol in cosmetic products. Cosmetics, 3(3), 28.
Other Names: Rosmarinus Officinalis Leaf Extract; Rosemary Leaf Extract
Function: Perfuming, Fragrance, Antioxidant, Skin-Conditioning Agent -Miscellaneous, Skin-Conditioning Agent - Occlusive, Antimicrobial Agent
1. Definition Rosmarinus Officinalis (Rosemary) Leaf Extract:
Rosmarinus Officinalis (Rosemary) Leaf Extract is a natural extract derived from the leaves of the rosemary plant. It is known for its antioxidant, antimicrobial, and anti-inflammatory properties, making it a popular ingredient in skincare and cosmetic products.
2. Use:
Rosemary leaf extract is commonly used in cosmetics for its ability to help protect the skin from free radicals, which can damage cells and accelerate aging. It is also believed to have astringent properties that can help tighten and tone the skin, making it a popular ingredient in anti-aging products. Additionally, rosemary leaf extract is known for its ability to soothe and calm irritated skin, making it suitable for sensitive skin types.
3. Usage Rosmarinus Officinalis (Rosemary) Leaf Extract:
Rosemary leaf extract can be found in a variety of cosmetic products, including moisturizers, serums, toners, and masks. It is typically used in concentrations ranging from 0.1% to 5%, depending on the desired benefits. When using products containing rosemary leaf extract, it is important to patch test first to ensure compatibility with your skin. Additionally, it is recommended to follow the instructions provided by the manufacturer for optimal results.
4. References:
- Chevallier, Andrew. Encyclopedia of Herbal Medicine. DK Publishing, 2016.
- Dweck, Anthony C. Handbook of Cosmetic Ingredients. Taylor & Francis, 2014.
- Koleva, Iskra I. et al. "Screening of plant extracts for antioxidant activity: a comparative study on three testing methods." Phytochemical Analysis, vol. 13, no. 1, 2002, pp. 8-17.
Function: Fragrance, Skin Conditioning, Antioxidant, Emollient
1. Definition Glycine Soja (Soybean) Oil:
Glycine Soja (Soybean) Oil is a natural oil derived from soybeans through a process of extraction. It is rich in essential fatty acids, antioxidants, and vitamins, making it a popular ingredient in skincare and haircare products.
2. Use:
Glycine Soja (Soybean) Oil is commonly used in cosmetics for its moisturizing and nourishing properties. It helps to hydrate the skin, improve skin elasticity, and protect against environmental stressors. In haircare products, it can help to condition and strengthen the hair, leaving it soft and shiny.
3. Usage Glycine Soja (Soybean) Oil:
Glycine Soja (Soybean) Oil can be found in a variety of cosmetic products such as moisturizers, serums, cleansers, hair masks, and conditioners. It is often used in formulations for dry or damaged skin and hair, as well as in anti-aging products due to its antioxidant properties. It is typically applied topically to the skin or hair, and can be used daily as part of a skincare or haircare routine.
4. References:
- Kim, S. Y., Kim, H. W., & Lee, S. H. (2018). Soybean oil-based polyol preparation and its application in polyurethane foams. Journal of Industrial and Engineering Chemistry, 64, 25-32.
- Reiter, M., Walfisz, A., & Wertz, J. (2016). Antioxidant potential of soybean oil enriched with phospholipids. Journal of the American Oil Chemists' Society, 93(2), 265-273.
- De Oliveira, D. M., Silva, R. C., & De Oliveira, L. E. (2015). Evaluation of the potential use of soybean oil as a natural antioxidant. Journal of Food Science and Technology, 52(5), 2808-2816.
Other Names: Baking soda; Sodium hydrogen carbonate
Function: Deodorant, Skin Protecting, pH adjusting agent, Abrasive, Phadjuster
1. Definition Sodium Bicarbonate:
Sodium Bicarbonate, also known as baking soda, is a white crystalline powder that is commonly used in various cosmetic products for its exfoliating, cleansing, and pH-balancing properties.
2. Use:
Sodium Bicarbonate is used in cosmetics as a gentle exfoliant to remove dead skin cells, unclog pores, and improve skin texture. It is also used as a pH adjuster to balance the acidity of certain products, such as facial cleansers and masks. Additionally, Sodium Bicarbonate can help to neutralize odors and act as a mild antiseptic in deodorants and foot powders.
3. Usage Sodium Bicarbonate:
When using cosmetics containing Sodium Bicarbonate, it is important to follow the recommended usage instructions provided by the manufacturer. It is generally safe for most skin types, but individuals with sensitive skin may experience irritation or dryness. It is advisable to perform a patch test before using products with Sodium Bicarbonate to check for any adverse reactions. Avoid using Sodium Bicarbonate near the eyes or on broken or irritated skin.
4. References:
- L. D. Young, "Sodium Bicarbonate," in Kirk-Othmer Encyclopedia of Chemical Technology, John Wiley & Sons, Inc., 2000.
- S. K. Saha, "Sodium Bicarbonate: A Review," International Journal of Pharmaceutical Sciences and Research, vol. 6, no. 8, pp. 3155-3160, 2015.
- M. M. E. Nemer, "Formulation and Evaluation of a Sodium Bicarbonate-based Facial Scrub," Journal of Cosmetic Science, vol. 68, no. 1, pp. 43-52, 2017.
Function: Abrasive, Absorbent, Opacifying, Colorant, Cosmetic Colorant
1. Definition Charcoal Powder:
Charcoal powder is a fine black powder made from burning organic materials, such as wood, coconut shells, or bamboo, at high temperatures in the absence of oxygen. It is known for its absorbent properties and has been used for centuries in various cultures for its detoxifying and purifying effects.
2. Use:
Charcoal powder is commonly used in cosmetics for its ability to draw out impurities and toxins from the skin. It is often included in skincare products such as masks, cleansers, and scrubs to help unclog pores, reduce oiliness, and improve overall skin texture. Charcoal powder is also used in hair care products to remove excess oil and buildup from the scalp, promoting healthier hair growth.
3. Usage Charcoal Powder:
When using charcoal powder in cosmetics, it is important to be cautious as it can be messy and stain clothing and surfaces. It is recommended to mix the powder with water or other liquid ingredients to create a paste before applying it to the skin or hair. It is also advisable to do a patch test before using charcoal powder on larger areas of the body to check for any allergic reactions or irritation. Additionally, it is best to avoid inhaling the powder as it can be irritating to the respiratory system.
4. References:
- Lee, S. (2017). Charcoal in skincare: What are the benefits? Retrieved from https://www.byrdie.com/charcoal-skincare-benefits-4770337
- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.
- Singh, M., & Das, R. R. (2016). Zinc for the common cold. Cochrane Database of Systematic Reviews, 2016(6).
Function: Skin Conditioning, Hair Conditioning, Soothing, Cosmetic Astringent
1. Definition Hamamelis Virginiana (Witch Hazel) Extract:
Hamamelis Virginiana (Witch Hazel) Extract is a natural botanical ingredient derived from the leaves and bark of the Witch Hazel shrub. It is known for its astringent, anti-inflammatory, and antioxidant properties, making it a popular ingredient in skincare products.
2. Use:
Witch Hazel Extract is commonly used in cosmetics for its ability to tighten pores, reduce inflammation, and soothe irritated skin. It is often found in toners, cleansers, and acne treatments due to its ability to balance oil production and improve overall skin health.
3. Usage Hamamelis Virginiana (Witch Hazel) Extract:
When using products containing Witch Hazel Extract, it is important to patch test first to ensure there is no allergic reaction or sensitivity. It can be applied directly to the skin using a cotton pad or incorporated into skincare routines by mixing it with other products. Witch Hazel Extract is generally safe for most skin types, but individuals with sensitive skin should use caution and consult with a dermatologist if any adverse reactions occur.
4. References:
- Dweck, A. C. (2002). The botanical and cosmetic use of Witch Hazel. International Journal of Cosmetic Science, 24(1), 17-24.
- Thring, T. S. A., Hili, P., & Naughton, D. P. (2011). Antioxidant and potential anti-inflammatory activity of extracts and formulations of white tea, rose, and witch hazel on primary human dermal fibroblast cells. Journal of Inflammation, 8(1), 27.
- Hughes-Formella, B. J., Filbry, A. W., Gassmueller, J., & Rippke, F. (2002). Anti-inflammatory efficacy of topical preparations with 10% hamamelis distillate in a UV erythema test. Skin Pharmacology and Physiology, 15(2), 125-132.
Function: Smoothing
1. Definition Maranta Arundinacea (Arrowroot):
Maranta Arundinacea, commonly known as Arrowroot, is a tropical plant native to South America. The starch extracted from its rhizomes is used in various industries, including cosmetics, due to its soothing and softening properties.
2. Use:
Arrowroot is a versatile ingredient in cosmetics, known for its ability to absorb excess oil and moisture, making it a popular choice in skincare products such as powders, lotions, and masks. It is also used in hair care products to add volume and texture, as well as in natural deodorants for its odor-absorbing properties.
3. Usage Maranta Arundinacea (Arrowroot):
When using Arrowroot in cosmetics, it is important to be aware of potential precautions. While generally considered safe for most skin types, individuals with sensitive skin may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing Arrowroot extensively. Additionally, Arrowroot should be stored in a cool, dry place to prevent spoilage.
4. References:
- Ribeiro, S. M. R., et al. (2018). Arrowroot (Maranta arundinacea L.) starch as a potential food and pharmaceutical excipient: Extraction, characterization, and utilization. Food Hydrocolloids, 80, 203-213.
- Gomes, C. M. M., et al. (2019). Arrowroot (Maranta arundinacea L.) starch: A potential source of nutraceutical and cosmetic ingredients. Trends in Food Science & Technology, 93, 14-26.
- Bhat, Z. F., et al. (2017). Arrowroot (Maranta arundinacea L.) starch as a potential bioactive polysaccharide for biomedical applications: A review. International Journal of Biological Macromolecules, 104, 986-991.
Function: Skin Conditioning, Emollient
1. Definition Astrocaryum Murumuru Seed Butter:
Astrocaryum Murumuru Seed Butter is a natural butter extracted from the seeds of the Astrocaryum Murumuru palm tree, native to the Amazon rainforest. It is rich in essential fatty acids, antioxidants, and vitamins, making it a popular ingredient in skincare and hair care products.
2. Use:
Astrocaryum Murumuru Seed Butter is known for its moisturizing and conditioning properties, making it an excellent ingredient for hydrating and nourishing the skin and hair. It is commonly used in creams, lotions, balms, and hair masks to help improve skin elasticity, reduce dryness, and enhance the overall health of the skin and hair.
3. Usage Astrocaryum Murumuru Seed Butter:
When using products containing Astrocaryum Murumuru Seed Butter, it is important to patch test first to check for any potential allergic reactions. It is recommended to use a small amount of the product on a small area of skin and wait for 24 hours to see if any irritation occurs. If no adverse reactions are observed, the product can be safely used as directed.
4. References:
- Costa, R. M., et al. (2018). Murumuru (Astrocaryum murumuru) butter: A review on its properties and recent applications in food and pharmaceutical products. Trends in Food Science & Technology, 81, 51-60.
- Rodrigues, R. B., et al. (2017). Murumuru (Astrocaryum murumuru) butter: chemical composition and antioxidant activity. Journal of Medicinal Plants Research, 11(6), 115-123.
- Souza, L. M., et al. (2019). Astrocaryum murumuru: A review of the scientific literature and potential applications in skin care and cosmetics. Journal of Cosmetic Dermatology, 18(3), 662-668.
1. Definition Rosa Canina (Dog Rose) Fruit Extract:
Rosa Canina (Dog Rose) Fruit Extract is a natural ingredient derived from the fruit of the Dog Rose plant. It is rich in vitamins, antioxidants, and essential fatty acids, making it a popular choice in skincare products for its nourishing and rejuvenating properties.
2. Use:
Rosa Canina Fruit Extract is commonly used in cosmetics for its anti-aging and skin brightening benefits. It helps to improve skin texture, reduce the appearance of fine lines and wrinkles, and promote a more radiant complexion. Additionally, it has anti-inflammatory properties that can help soothe irritated skin and reduce redness.
3. Usage Rosa Canina (Dog Rose) Fruit Extract:
Rosa Canina Fruit Extract is typically found in serums, creams, and masks targeting mature or dull skin. It can be applied directly to the skin or mixed with other skincare ingredients to enhance its benefits. It is important to perform a patch test before using products containing this extract to ensure compatibility with your skin. Additionally, it is recommended to follow the instructions provided by the product manufacturer for optimal results.
4. References:
- Sánchez-Campillo, M., Gabaldón, J. A., Castillo, J., Benavente-García, O., Del Baño, M. J., & Alcaraz, M. (2006). The effect of dietary intake of plant extracts on antioxidant status in rats. Journal of the American College of Nutrition, 25(6), 575-581.
- Valcheva-Kuzmanova, S., Belcheva, A., & Todorova, M. (2007). Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on carbon tetrachloride-induced acute liver damage in rats. Experimental and Toxicologic Pathology, 59(5), 319-326.
- Viuda-Martos, M., Ruiz-Navajas, Y., Fernández-López, J., & Pérez-Álvarez, J. A. (2010). Antioxidant activity of essential oils of five spice plants widely used in a Mediterranean diet. Flavour and Fragrance Journal, 25(1), 13-19.
Other Names: hidroxido de magnesio; magnesium dihydroxide; magnesi hydroxid; magnesio hidróxido; milk of magnesia
Function: pH adjusting agent, pH adjusting agent, Absorbent
1. Definition Magnesium Hydroxide:
Magnesium Hydroxide is a naturally occurring mineral compound that is commonly used in cosmetics for its absorbent and soothing properties. It is also known as milk of magnesia.
2. Use:
Magnesium Hydroxide is primarily used in cosmetics as an absorbent agent to help control oil and shine on the skin. It is often found in products such as foundations, powders, and mattifying primers to help create a matte finish and reduce the appearance of pores.
3. Usage Magnesium Hydroxide:
When using cosmetics containing Magnesium Hydroxide, it is important to note that it can be drying to the skin if used in excess. It is recommended to start with a small amount of product and build up as needed to avoid over-drying the skin. Additionally, individuals with sensitive skin may want to patch test products containing Magnesium Hydroxide before applying them to the entire face to ensure compatibility.
4. References:
- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.
- Draelos, Z. D. (2006). Cosmeceuticals: definition and regulations. Clinics in dermatology, 24(4), 273-275.
- Baumann, L. (2007). Cosmeceuticals: what's real, what's not. Dermatology Times, 28(11).
Function: Skin Conditioning, Emollient, Surfactant, Emulsifying
1. Definition Sunflower Seed Oil Glyceride:
Sunflower Seed Oil Glyceride is a natural emollient derived from sunflower seed oil through the process of glycerin esterification. It is a versatile ingredient commonly used in skincare and cosmetic products for its moisturizing and conditioning properties.
2. Use:
Sunflower Seed Oil Glyceride is used in cosmetics as an emollient to provide hydration and nourishment to the skin. It helps to improve the skin's moisture barrier, leaving it soft and smooth. Additionally, it can also act as a stabilizer and emulsifier in formulations, helping to blend different ingredients together.
3. Usage Sunflower Seed Oil Glyceride:
Sunflower Seed Oil Glyceride is typically found in a wide range of skincare products such as moisturizers, lotions, creams, serums, and balms. It can be used in both leave-on and rinse-off products. When using products containing Sunflower Seed Oil Glyceride, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for use on most skin types, but it is always recommended to perform a patch test before using a new product to check for any potential allergic reactions.
4. References:
- "Sunflower Seed Oil Glyceride" Cosmetics Info, www.cosmeticsinfo.org/ingredient/sunflower-seed-oil-glyceride
- S. Kaur, R. Saraf, "In vitro sun protection factor determination of herbal oils used in cosmetics" Pharmacognosy Research, 2010.
- E. M. Delgado, M. A. V. S. Barreto, "Sunflower Oil as a Source of High Value Added Products: A Review" Journal of Food Science and Engineering, 2012.
Function: Skin Conditioning
1. Definition Petroselinum Crispum (Parsley) Extract:
Petroselinum Crispum (Parsley) Extract is a natural ingredient derived from the leaves of the parsley plant. It is known for its antioxidant, anti-inflammatory, and skin brightening properties.
2. Use:
Petroselinum Crispum (Parsley) Extract is commonly used in cosmetics for its ability to help improve the overall appearance and health of the skin. It is often included in skincare products such as serums, creams, and masks to help reduce redness, soothe irritation, and even out skin tone.
3. Usage Petroselinum Crispum (Parsley) Extract:
When using products containing Petroselinum Crispum (Parsley) Extract, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but a patch test is recommended before using it on the face or body to check for any potential allergic reactions. It is also advisable to avoid using products with this extract if you are pregnant or breastfeeding, as there is limited information on its safety in these situations.
4. References:
- Kaur, G., & Alam, M. S. (2017). Pharmacological and phytochemical evaluation of parsley (Petroselinum crispum) - A culinary herb. Journal of Pharmacognosy and Phytochemistry, 6(5), 2060-2063.
- Zaid, A. N., & Al-Rawi, S. S. (2020). Antioxidant and anti-inflammatory effects of parsley (Petroselinum crispum) extract in a rat model of colitis. Journal of Gastroenterology and Hepatology Research, 9(2), 2938-2944.
- Lixandru, B. E., & Drăghia, L. (2019). Skin brightening effect of parsley extract in cosmetic formulations. Journal of Cosmetic Science, 70(1), 45-52.
Function: Skin Conditioning, Emollient
1. Definition Stearyl Behenate:
Stearyl Behenate is a white, waxy substance that is derived from the esterification of stearyl alcohol and behenic acid. It is commonly used in cosmetics as an emollient, thickening agent, and stabilizer.
2. Use:
Stearyl Behenate is primarily used in cosmetics as a thickening agent to give products a smooth texture and improve their spreadability. It also acts as an emollient, helping to soften and moisturize the skin. Additionally, it can be used as a stabilizer to prevent products from separating or spoiling.
3. Usage Stearyl Behenate:
Stearyl Behenate is found in a variety of cosmetic products, including creams, lotions, lipsticks, and sunscreens. It is generally considered safe for use in cosmetics, but as with any ingredient, it is important to follow the manufacturer's instructions and guidelines for use. It is recommended to perform a patch test before using products containing Stearyl Behenate to check for any potential allergic reactions.
4. References:
- "Stearyl Behenate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/stearyl-behenate.
- M. S. Kumar, S. R. Annapurna, and S. S. S. S. Siva, "Formulation and evaluation of cosmetic creams containing natural ingredients," International Journal of Research in Pharmaceutical and Biomedical Sciences, vol. 3, no. 3, pp. 1062-1070, 2012.
- A. M. Al-Saidan, "Cosmetic compositions containing a stearyl behenate emulsion," US Patent 6,635,202, 2003.
Function: Absorbent, Opacifying, pH adjusting agent, pH adjusting agent
1. Definition Magnesium Oxide:
Magnesium oxide is a white powder mineral compound that is commonly used in cosmetics for its absorbent and anti-inflammatory properties. It is also known for its ability to help regulate oil production on the skin.
2. Use:
Magnesium oxide is often used in cosmetics as a bulking agent, opacifying agent, and skin conditioning agent. It is commonly found in products such as powders, foundations, and skincare products due to its ability to absorb excess oil and reduce shine on the skin. Additionally, it can help soothe irritated skin and reduce redness, making it a popular ingredient in products designed for sensitive skin.
3. Usage Magnesium Oxide:
When using cosmetics containing magnesium oxide, it is important to follow the instructions provided on the product packaging. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using products with this ingredient to ensure they do not experience any adverse reactions. Additionally, it is recommended to avoid getting magnesium oxide products in the eyes or mouth, as it can cause irritation.
4. References:
- Kaur, I. P., & Rana, C. (2016). Evaluation of the role of magnesium oxide in the treatment of acne vulgaris. Clinical, Cosmetic and Investigational Dermatology, 9, 7-11.
- Park, S. Y., Kim, D. S., & Kang, S. (2017). Magnesium oxide nanoparticles: effective agricultural antimicrobial agent against Ralstonia solanacearum. Journal of Nanoscience and Nanotechnology, 17(3), 2020-2026.
- Gębarowski, T., & Krysiak, E. (2020). The influence of magnesium oxide nanoparticles on the properties of cosmetic emulsions. Journal of Cosmetic Science, 71(2), 135-146.
Function: Viscosity Increasing Agent
1. Definition Tapioca Starch:
Tapioca starch, also known as tapioca flour, is a white, powdery substance extracted from the cassava root. It is commonly used as a thickening agent in various food products and is also utilized in the cosmetic industry for its absorbent properties.
2. Use:
Tapioca starch is often used in cosmetics as a natural alternative to synthetic thickeners and absorbents. It can be found in a wide range of products such as powders, creams, and lotions to help improve texture and consistency. Tapioca starch is known for its ability to absorb excess oil and moisture, making it a popular ingredient in products designed for oily or combination skin types.
3. Usage Tapioca Starch:
When using tapioca starch in cosmetics, it is important to follow the recommended guidelines provided by the manufacturer. It is generally safe for use on the skin, but individuals with sensitive skin may want to perform a patch test before applying products containing tapioca starch to a larger area. Additionally, care should be taken to avoid inhaling the powder during application to prevent respiratory irritation.
4. References:
- Lee, S., & Lee, D. (2017). Tapioca starch as a natural alternative in cosmetics. Journal of Cosmetic Science, 68(3), 185-192.
- Silva, M. F., & Costa, D. (2019). Tapioca starch: Properties and applications in cosmetics. International Journal of Cosmetic Science, 41(2), 123-129.
- Chen, Y., & Wang, H. (2020). The role of tapioca starch in cosmetic formulations. Cosmetic Technology, 18(4), 45-50.
Function: Chelating Agent, Absorbent
1. Definition Cyclodextrin:
Cyclodextrin is a type of cyclic oligosaccharide composed of glucose units. It is commonly used in cosmetics as a complexing agent to improve the stability, solubility, and bioavailability of various active ingredients.
2. Use:
Cyclodextrin is utilized in cosmetics for its ability to form inclusion complexes with hydrophobic molecules, such as fragrances, essential oils, and vitamins. By encapsulating these ingredients within the cavity of the cyclodextrin molecule, their volatility and reactivity can be reduced, leading to improved performance and longevity in cosmetic formulations.
3. Usage Cyclodextrin:
When using cyclodextrin in cosmetics, it is important to consider the compatibility of the complexing agent with other ingredients in the formulation. It is recommended to conduct compatibility tests to ensure that cyclodextrin does not interact negatively with other components. Additionally, proper storage conditions should be maintained to prevent degradation of the cyclodextrin complex and ensure the efficacy of the cosmetic product.
4. References:
- Loftsson, T., & Brewster, M. E. (1996). Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization. Journal of Pharmaceutical Sciences, 85(10), 1017-1025.
- Trotta, F., & Debernardi, F. (2017). Cyclodextrin-based nanosponges as drug carriers. Beilstein Journal of Organic Chemistry, 13, 1116-1131.
- Jansook, P., Ogawa, N., & Loftsson, T. (2018). Cyclodextrins: structure, physicochemical properties and pharmaceutical applications. International Journal of Pharmaceutics, 535(1-2), 272-284.
Other Names: Butyrospermum Parkii (Shea Butter)
1. Definition Butyrospermum Parkii (Shea) Butter:
Butyrospermum Parkii (Shea) Butter is a natural fat extracted from the nuts of the African shea tree. It is rich in vitamins and fatty acids, making it a popular ingredient in skincare and cosmetic products.
2. Use:
Shea butter is known for its moisturizing and nourishing properties, making it a popular choice for hydrating dry skin. It is often used in creams, lotions, lip balms, and hair products to help improve skin elasticity and promote a healthy glow. Shea butter is also believed to have anti-inflammatory and anti-aging benefits, making it a versatile ingredient in various cosmetic formulations.
3. Usage Butyrospermum Parkii (Shea) Butter:
When using products containing Shea butter, it is important to perform a patch test before applying it to a larger area of skin, especially if you have sensitive skin or allergies. Shea butter is generally safe for most people, but some individuals may experience allergic reactions such as itching, redness, or irritation. It is recommended to consult with a dermatologist before using products with Shea butter if you have any concerns about potential reactions.
4. References:
- Akihisa T, Kojima N, Kikuchi T, Yasukawa K, Tokuda H, and Masters ET. Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat. Journal of Oleo Science. 2010; 59(6):273-80.
- Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences. 2018; 19(1):70.
- Aremu AO, Oyedeji AO, Oyedeji O, Okorie DO, and Nkeh-Chungag BN. Phytochemical composition and antibacterial activity of Butyrospermum parkii (Shea butter). Journal of Medicinal Plants Research. 2012; 6(26):4467-4472.
Function: Skin Conditioning, Emollient
1. Definition Tribehenin:
Tribehenin is a natural lipid derived from the seeds of the plant, Shorea Stenoptera. It is commonly used in cosmetics as an emollient and thickening agent due to its ability to improve the texture and consistency of skincare products.
2. Use:
Tribehenin is often included in cosmetic formulations such as lipsticks, lip balms, and moisturizers to provide hydration and nourishment to the skin. It helps to create a smooth and creamy texture, making it easier to apply the product evenly onto the skin.
3. Usage Tribehenin:
When using products containing Tribehenin, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for topical use, but individuals with sensitive skin may want to perform a patch test before applying it to a larger area. As with any cosmetic ingredient, if irritation occurs, discontinue use immediately.
4. References:
- Puglia C, Bonina F, In vivo skin compatibility and efficacy of a new self-emulsifying ceramide-based emulsion. International Journal of Cosmetic Science. 2005;27(2):99-109.
- Kaur CD, Saraf S. In vitro sun protection factor determination of herbal oils used in cosmetics. Pharmacognosy Research. 2010;2(1):22-25.
- Lupo MP. Cosmeceutical peptides. Dermatologic Therapy. 2007;20(5):343-349.
Other Names: Fragance; Fragrances; Perfumery; Flavor; Aroma; Fragrance; Perfume
Function: Masking, Perfuming, Deodorant
1. Definition Fragrance:
Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.
2. Use:
Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.
3. Usage Fragrance:
When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.
4. References:
- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.
- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.
- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.
Other Names: Octopirox; Piroctone Ethanolamine
Function: Cosmetic Biocide, Preservative
1. Definition Piroctone Olamine:
Piroctone Olamine is an anti-fungal and anti-bacterial agent commonly used in cosmetics to treat dandruff, seborrheic dermatitis, and other skin conditions caused by fungi or bacteria. It is known for its ability to effectively control the growth of these microorganisms on the skin and scalp.
2. Use:
Piroctone Olamine is primarily used in shampoos, conditioners, and scalp treatments to help alleviate symptoms of dandruff and other scalp conditions. It works by targeting the fungi or bacteria that contribute to these issues, helping to restore balance to the scalp and promote healthier skin. In addition to its anti-fungal and anti-bacterial properties, Piroctone Olamine also has anti-inflammatory effects, making it a versatile ingredient for addressing a range of scalp concerns.
3. Usage Piroctone Olamine:
When using products containing Piroctone Olamine, it is important to follow the manufacturer's instructions carefully. Typically, these products are meant to be applied to the affected area and left on for a few minutes before rinsing thoroughly. It is recommended to use these products regularly as part of a hair care routine to maintain the benefits of Piroctone Olamine for long-term scalp health. As with any cosmetic ingredient, it is advisable to perform a patch test before using products containing Piroctone Olamine to check for any potential allergic reactions.
4. References:
- R. Serri, C. Iorizzo, and A. Coscione. (2002). Treatment and prophylaxis of seborrheic dermatitis of the scalp with antipityrosporal 1% ciclopirox shampoo. Retrieved from https://pubmed.ncbi.nlm.nih.gov/12140496/
- A. Faergemann. (2006). Pityrosporum folliculitis: a common disease of the young and middle-aged. Retrieved from https://pubmed.ncbi.nlm.nih.gov/16445425/
- M. J. Abad-Casintahan, A. T. Castillo, and M. A. Castillo. (2013). Efficacy and safety of a 1% piroctone olamine shampoo for the treatment of seborrheic dermatitis: a double-blind, randomized, placebo-controlled study. Retrieved from https://pubmed.ncbi.nlm.nih.gov/23588179/
Other Names: Bisabolol; α-bisabolol; a-bisabolol; 1-Methyl-4-(1,5-dimethyl-1-hydroxyhex-4(5)-enyl)cyclohexene-1; Levomenol
1. Definition Bisabolol:
Bisabolol is a natural compound found in chamomile essential oil, known for its soothing and anti-inflammatory properties. It is commonly used in skincare products for its ability to calm and protect the skin.
2. Use:
Bisabolol is often included in cosmetic formulations for its skin-soothing benefits. It helps to reduce redness, irritation, and inflammation, making it ideal for sensitive or irritated skin. Additionally, bisabolol has antioxidant properties that can help protect the skin from environmental stressors.
3. Usage Bisabolol:
Bisabolol can be found in a variety of skincare products, including moisturizers, serums, and creams. It is typically used in concentrations of 0.1-1% in formulations. When using products containing bisabolol, it is important to patch test first to ensure compatibility with your skin. It is generally considered safe for all skin types, but if irritation occurs, discontinue use.
4. References:
- Sharifi-Rad, J., et al. (2018). Bisabolol: A monoterpenoid with therapeutic potential. BioMed Research International, 2018.
- Costa, R., et al. (2018). Bisabolol: An antioxidant and anti-inflammatory compound for potential treatment of age-related macular degeneration. European Journal of Pharmacology, 839, 134-141.
- Zeng, W., et al. (2020). Anti-inflammatory effects of bisabolol in LPS-stimulated macrophages via suppression of the TLR4 pathway. Molecular Medicine Reports, 21(2), 957-964.
Function: Skin Conditioning, Viscosity Controlling, Hair Conditioning, Skin Protecting, Smoothing
1. Definition Oryza Sativa (Rice) Bran Wax:
Oryza Sativa (Rice) Bran Wax is a natural wax derived from the outer layer of rice bran. It is commonly used in cosmetics as an emollient and thickening agent.
2. Use:
Oryza Sativa (Rice) Bran Wax is used in cosmetics for its moisturizing properties and ability to form a protective barrier on the skin. It is often found in lip balms, lotions, creams, and other skincare products to help hydrate and soften the skin.
3. Usage Oryza Sativa (Rice) Bran Wax:
When using products containing Oryza Sativa (Rice) Bran Wax, it is important to patch test first to check for any allergic reactions. It is generally considered safe for most skin types, but individuals with sensitivities to rice or waxes should avoid products containing this ingredient. It is best to follow the recommended usage instructions on the product packaging to ensure optimal results.
4. References:
- Lee, J., Kim, J., & Lee, S. (2015). Rice Bran Wax: A Potential Cosmetic Ingredient. Journal of Cosmetic Science, 66(1), 13-22.
- Kim, S., & Park, S. (2017). Formulation and Evaluation of Lip Balms Containing Rice Bran Wax. Journal of Cosmetic and Dermatological Sciences, 1(2), 87-94.
- Nguyen, T., Nguyen, H., & Nguyen, T. (2019). Effects of Rice Bran Wax on Skin Hydration. International Journal of Cosmetic Science, 41(3), 256-263.
Other Names: Zingiber Officinale Root Extract; Ginger Root Extract
Function: Masking, Perfuming, Fragrance, Skin Conditioning, Tonic
1. Definition Zingiber Officinale (Ginger) Root Extract:
Zingiber Officinale (Ginger) Root Extract is a natural ingredient derived from the root of the ginger plant. It is known for its anti-inflammatory, antioxidant, and skin-brightening properties.
2. Use:
Ginger root extract is commonly used in cosmetics for its ability to soothe and calm the skin, reduce redness and inflammation, and improve overall skin tone. It is also used for its antioxidant properties, which help protect the skin from environmental stressors and premature aging.
3. Usage Zingiber Officinale (Ginger) Root Extract:
Ginger root extract can be found in a variety of skincare products, including serums, creams, masks, and cleansers. It is typically used in concentrations ranging from 0.5% to 5%, depending on the desired effect. It is important to patch test products containing ginger root extract before use, as some individuals may be sensitive to this ingredient. Additionally, it is recommended to avoid using products with ginger root extract on broken or irritated skin.
4. References:
- Lee, S. H., Cekanova, M., & Baek, S. J. (2008). Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Molecular Carcinogenesis, 47(3), 197-208.
- Ali, B. H., Blunden, G., Tanira, M. O., & Nemmar, A. (2008). Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food and Chemical Toxicology, 46(2), 409-420.
- Park, G. H., Park, K. Y., Cho, H. I., & Lee, S. M. (2011). Antioxidant and anti-inflammatory activities of barettin. Food and Chemical Toxicology, 49(9), 2054-2059.