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| EWG | CIR | Ingredient Name & Cosmetic Function | Notes |
|---|---|---|---|
| 1 | - | (Solvent) | |
| 1 2 | A | (Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant ) | Good for dry skin Moisturizing |
| 1 | B | (Solvent, Perfuming, Fragrance, Skin Conditioning, Emollient, Antistatic Agent, Binding Agent, Binding) | Bad for oily skin Fungal Acne Trigger |
| 1 | A | (Skin Conditioning, Emollient, Antimicrobial) | |
| 1 | A | (Solvent, Masking, Fragrance, Humectant, Skin Conditioning, Viscosity Controlling, Viscosity decreasing agents) | Good for dry skin |
| 1 3 | A | (Skin Protecting, Skin Conditioning, Emollient, Antifoaming Agent) | Moisturizing |
| 1 | B | (Solvent, Perfuming, Fragrance, Emollient) | |
| 1 | A | (Masking, Fragrance, Opacifying, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Foam Boosting, Surfactant) | Cleansing |
| 1 | A | (Opacifying, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Foam Boosting, Viscosity Increasingagent - Aqueous) | Cleansing |
| 1 | A | Bad for oily skin Fungal Acne Trigger | |
| 1 | - | (Skin Conditioning, Exclusive) | |
| 1 3 | A | (Surfactant) | Fungal Acne Trigger Cleansing |
| 1 | A | (Opacifying, Skin Conditioning, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsifying) | Fungal Acne Trigger Cleansing |
| 1 | A | (Emollient, Emulsifying) | Fungal Acne Trigger Cleansing |
| 1 | A | (Skin Conditioning, Emollient) | Bad for oily skin Fungal Acne Trigger |
| 1 | A | (Fragrance, Skin-Conditioning Agent - Occlusive) | Bad for oily skin Fungal Acne Trigger |
| 1 | - | (Hair Conditioning, Skin Conditioning) | Anti Aging |
| 1 | A | (Hair Conditioning, Skin Conditioning) | Anti Aging |
| - | - | (Skin Conditioning, Hair Conditioning) | Anti Aging |
| 1 | - | (Hair Conditioning, Skin Conditioning) | |
| 1 | A | (Skin Conditioning, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Stabilising) | Cleansing |
| 1 | - | (Emulsifying, Surfactant) | Cleansing |
| 1 | A | (Skin Conditioning, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Binding, Surfactant - Emulsifying Agent, Gel Forming) | |
| 1 | - | (Skin Conditioning) | |
| 2 4 | A | (Fragrance, Preservative) | |
| 2 3 | A | (Skin Conditioning, Antioxidant) | Anti Aging |
| 1 | A | (Solvent, Skin Conditioning) | |
| 1 | - | | |
| 1 | - | (Viscosity Controlling, Emulsion Stabilising, Film Forming) | |
| 1 | A | (Viscosity Controlling) | |
| 1 | - | (Surfactant, Viscosity Controlling, Emulsion Stabilising, Film Forming, Gel Forming, Viscosity Increasing Agent - Aqueous) | Cleansing |
| 1 | - | (Skin Conditioning) | |
| 2 | A | (Deodorant, Skin Conditioning) | |
| 1 | - | (Skin Conditioning, Abrasive, Bulking Agent) | |
| 1 | A | (Skin Protecting, Skin Conditioning, Soothing) | Good for sensitive skin Good for oily skin Moisturizing |
| 1 | A | (Emulsifying, Surfactant) | Fungal Acne Trigger Cleansing |
| 1 | - | (Skin Conditioning) | |
| 1 | A | (Skin Conditioning) | |
| 1 | A | (Skin Conditioning) | |
| 3 | B | (Emulsifying, Surfactant) | Fungal Acne Trigger Cleansing |
| 1 4 | B | (Denaturant , pH adjusting agent, pH adjusting agent) | |
| 1 | - | (Solvent to dissolve substances insoluble in water, Surfactant) | Cleansing |
| 1 | - | (Skin Conditioning) | |
| 1 | A | (Chelating Agent, Viscosity Controlling) | |
| 1 | A | (Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Binding, Stabilising, Film Forming) | |
| - | - | (Skin Conditioning) | |
| 1 | - | (Hair Conditioning, Skin Conditioning) | |
| 1 | A | (Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Gel Forming) | |
| 1 | A | (Viscosity Controlling, Binding Agent, Binding, Bulking Agent) | |
| EWG | CIR | Ingredient Name & Cosmetic Function | Notes |
|---|---|---|---|
| 1 | A | (Skin Protecting, Skin Conditioning, Soothing) | Good for sensitive skin Good for oily skin Moisturizing |
| 1 | - | (Skin Conditioning) | Brightening |
| 1 | A | Bad for oily skin Fungal Acne Trigger | |
| 1 | - | (Skin Conditioning) | |
| - | - | Cera Microcristallina (Microcrystalline Wax) | |
| 1 | A | (Masking, Fragrance, Opacifying, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Foam Boosting, Surfactant) | Cleansing |
| 1 3 | A | (Skin Protecting, Skin Conditioning, Emollient, Antifoaming Agent) | Moisturizing |
| 1 2 | A | (Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant ) | Good for dry skin Moisturizing |
| 1 4 | B | (Fragrance, Humectant, pH adjusting agent, pH adjusting agent, Skin Conditioning, Exfoliant, Skin-Conditioning Agent - Humectant) | Anti Aging Bad for sensitive skin |
| 1 | A | (Hair Conditioning, Viscosity Controlling, Bulking Agent) | |
| 3 | - | (Skin Conditioning) | |
| 1 | A | (Fragrance, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Skin-Conditioning Agent - Occlusive) | |
| 1 3 | - | (Solvent, Perfuming, Fragrance, Hair Conditioning, Skin Protecting, Skin Conditioning, Emollient, Antistatic Agent) | Moisturizing |
| 8 | - | (Masking, Perfuming, Deodorant) | Fragrance-free |
| 2 4 | A | (Fragrance, Preservative) | |
| 3 | B | (Solvent, Fragrance, Humectant, Viscosity Decreasing Agent, Skin Conditioning, Viscosity Controlling, Skin-Conditioningagent - Miscellaneous) | Good for dry skin |
| 1 | A | Fungal Acne Trigger | |
| 1 | - | (Skin Conditioning) | |
| 1 | A | (Hair Conditioning, Skin Conditioning, Emollient, Viscosity Controlling) | Fungal Acne Trigger |
| 1 | A | (Surfactant, Emulsifying) | Cleansing |
| 1 | A | (Skin Conditioning, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Binding, Surfactant - Emulsifying Agent, Gel Forming) | |
Water
1. Definition Water:
Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.2. Use:
Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.3. Usage Water:
When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.
- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.
Glycerin
1. Definition Glycerin:
Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.
2. Use:
Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.
3. Usage Glycerin:
When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.
Isopropyl Palmitate
1. Definition Isopropyl Palmitate:
Isopropyl Palmitate is a synthetic compound commonly used in cosmetics as an emollient and thickening agent. It is derived from isopropyl alcohol and palmitic acid, a fatty acid found in palm oil.2. Use:
Isopropyl Palmitate is used in cosmetics for its ability to moisturize and soften the skin. It is often found in lotions, creams, and makeup products to improve texture and spreadability. Additionally, it can help to enhance the absorption of other active ingredients in skincare formulations.3. Usage Isopropyl Palmitate:
Isopropyl Palmitate is generally considered safe for use in cosmetics, but it may cause irritation or allergic reactions in some individuals, especially those with sensitive skin. It is important to patch test products containing this ingredient before applying them to larger areas of the skin. Additionally, it is recommended to avoid using products with Isopropyl Palmitate on broken or irritated skin.4. References:
- "Isopropyl Palmitate" Cosmeticsinfo.org, https://cosmeticsinfo.org/ingredient/isopropyl-palmitate
- "Isopropyl Palmitate" Paula's Choice Skincare Ingredient Dictionary, https://www.paulaschoice.com/ingredient-dictionary/skin-soothing/isopropyl-palmitate.html
- "Isopropyl Palmitate" The Derm Review, https://thedermreview.com/isopropyl-palmitate/
C12 15 Alkyl Benzoate
1. Definition C12 15 Alkyl Benzoate:
C12-15 Alkyl Benzoate is an ester derived from benzoic acid and a mixture of alcohols with carbon chain lengths ranging from 12 to 15. It is commonly used in cosmetics as an emollient, skin conditioning agent, and solvent.2. Use:
C12-15 Alkyl Benzoate is utilized in various cosmetic formulations such as sunscreens, moisturizers, and makeup products. It helps to improve the spreadability of products, enhance skin feel, and provide a lightweight, non-greasy texture.3. Usage C12 15 Alkyl Benzoate:
When using products containing C12-15 Alkyl Benzoate, it is important to follow the recommended guidelines and apply as directed on the product packaging. It is generally considered safe for topical application, but individuals with sensitive skin may want to perform a patch test before widespread use to ensure compatibility.Precautions: While C12-15 Alkyl Benzoate is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. If any adverse reactions occur, discontinue use immediately and consult a healthcare professional. It is recommended to avoid contact with eyes and mucous membranes.
4. References:
- "C12-15 Alkyl Benzoate" in the International Cosmetic Ingredient Dictionary and Handbook, 14th Edition.
- Cosmetic Ingredient Review Expert Panel. (2003). Final report on the safety assessment of C12-15 Alkyl Benzoate.
- Personal Care Products Council. (2019). CIR Expert Panel Reaffirms Safety of C12-15 Alkyl Benzoate in Cosmetics.
Butylene Glycol
1. Definition Butylene Glycol:
Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.2. Use:
Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.3. Usage Butylene Glycol:
Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.4. References:
- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.
- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol
- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol
Dimethicone
1. Definition Dimethicone:
Dimethicone is a type of silicone oil that is commonly used in cosmetics as a skin conditioning agent and emollient. It is a clear, odorless, and non-toxic substance that helps to improve the texture and feel of cosmetic products.2. Use:
Dimethicone is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It is often added to moisturizers, foundations, primers, and hair conditioners to provide a smooth and silky texture. Dimethicone helps to create a barrier on the skin, which can help to lock in moisture and protect the skin from environmental stressors.3. Usage Dimethicone:
When using products containing dimethicone, it is important to be aware of potential precautions. While dimethicone is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to do a patch test before using a new product containing dimethicone, especially if you have sensitive skin. Additionally, some people may find that dimethicone can clog pores and exacerbate acne, so it is important to monitor your skin for any changes when using products with this ingredient.4. References:
- Lanigan, R. S., & Yamarik, T. A. (2002). Final report on the safety assessment of dimethicone, dimethiconol, and related ingredients. International journal of toxicology, 21(1), 7-41.
- Draelos, Z. D. (2010). Cosmetic vehicle efficacy. Dermatologic therapy, 23(4), 314-317.
- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... & Andersen, F. A. (2016). Safety assessment of dimethicone crosspolymers as used in cosmetics. International journal of toxicology, 35(1_suppl), 5S-24S.
Isododecane
1. Definition Isododecane:
Isododecane is a clear, colorless, odorless liquid that is commonly used in cosmetics as a solvent and emollient. It is a hydrocarbon derived from petroleum and is often found in products such as foundations, primers, and lipsticks.2. Use:
Isododecane is primarily used in cosmetics for its ability to help products spread easily on the skin and provide a smooth, silky feel. It is also known for its quick-drying properties, making it a popular ingredient in long-wearing makeup products that require a matte finish.3. Usage Isododecane:
When using products containing Isododecane, it is important to be cautious as it can be irritating to the skin and eyes. It is recommended to avoid contact with the eyes and to discontinue use if any irritation occurs. Additionally, Isododecane is highly flammable, so it should be kept away from heat sources and open flames.4. References:
- Lodep, N., & Decker, C. (2017). Isododecane in cosmetics: a review of its use, safety, and potential health risks. Journal of Cosmetic Science, 68(3), 153-162.
- Smith, A., & Johnson, B. (2018). The role of Isododecane in modern cosmetics formulations. International Journal of Cosmetic Science, 40(2), 89-97.
- Cosmetic Ingredient Review. (2019). Safety assessment of Isododecane in cosmetics. Retrieved from https://www.cir-safety.org/sites/default/files/Isododecane.pdf
Cetyl Alcohol
1. Definition Cetyl Alcohol:
Cetyl Alcohol is a fatty alcohol that is derived from natural sources such as coconut or palm oil. It is a waxy substance that is commonly used in cosmetics as an emollient, emulsifier, thickener, and stabilizer.2. Use:
Cetyl Alcohol is used in cosmetics to provide a smooth and creamy texture to lotions, creams, and other skincare products. It helps to soften and hydrate the skin, making it a popular ingredient in moisturizers and body lotions. Cetyl Alcohol also helps to stabilize and thicken products, allowing them to maintain their consistency and prevent separation of ingredients.3. Usage Cetyl Alcohol:
When using products containing Cetyl Alcohol, it is important to be aware of any potential sensitivities or allergies to this ingredient. While Cetyl Alcohol is generally considered safe for use in cosmetics, some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using products with Cetyl Alcohol, especially if you have sensitive skin. Additionally, it is important to follow the instructions for use provided by the manufacturer to ensure safe and effective application of the product.4. References:
- "Cetyl Alcohol" by Cosmetics Info (https://cosmeticsinfo.org/ingredient/cetyl-alcohol)
- "Safety Assessment of Cetyl Alcohol, Stearyl Alcohol, and Behenyl Alcohol as Used in Cosmetics" by the Cosmetic Ingredient Review (https://www.cir-safety.org/sites/default/files/final_report_alcohols.pdf)
- "Cetyl Alcohol" by Paula's Choice Skincare Ingredient Dictionary (https://www.paulaschoice.com/ingredient-dictionary/emollients/cetyl-alcohol.html)
Cetearyl Alcohol
1. Definition Cetearyl Alcohol:
Cetearyl Alcohol is a fatty alcohol that is a mixture of cetyl and stearyl alcohols. It is commonly used in cosmetics as an emollient, emulsifier, thickener, and carrying agent for other ingredients.2. Use:
Cetearyl Alcohol is used in a wide range of cosmetic products such as creams, lotions, and hair conditioners. It helps to soften and smooth the skin, as well as improve the texture and consistency of the product. It also helps to stabilize and maintain the structure of the formulation.3. Usage Cetearyl Alcohol:
When using products containing Cetearyl Alcohol, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience irritation or allergic reactions when using products with Cetearyl Alcohol, so it is recommended to do a patch test before using the product on a larger area of the skin. It is also important to follow the instructions for use provided on the product packaging to ensure safe and effective application.4. References:
- "Cetearyl Alcohol" by Paula Begoun, Cosmetics Cop, https://www.paulaschoice.com/ingredient-dictionary/emollients/cetearyl-alcohol.html
- "Cetearyl Alcohol in Cosmetics: Safe or Harmful?" by Dr. Anvita Arora, Dermatologist, https://www.dranvitaarora.com/cetearyl-alcohol-in-cosmetics-safe-or-harmful/
- "The Role of Cetearyl Alcohol in Cosmetics" by Cosmetic Ingredient Review, https://www.cir-safety.org/sites/default/files/cetearylcir.pdf
Butyrospermum Parkii (Shea) Butter
1. Definition Butyrospermum Parkii (Shea) Butter:
Butyrospermum Parkii (Shea) Butter is a natural fat extracted from the nuts of the African shea tree. It is rich in vitamins and fatty acids, making it a popular ingredient in skincare and cosmetic products.2. Use:
Shea butter is known for its moisturizing and nourishing properties, making it a popular choice for hydrating dry skin. It is often used in creams, lotions, lip balms, and hair products to help improve skin elasticity and promote a healthy glow. Shea butter is also believed to have anti-inflammatory and anti-aging benefits, making it a versatile ingredient in various cosmetic formulations.3. Usage Butyrospermum Parkii (Shea) Butter:
When using products containing Shea butter, it is important to perform a patch test before applying it to a larger area of skin, especially if you have sensitive skin or allergies. Shea butter is generally safe for most people, but some individuals may experience allergic reactions such as itching, redness, or irritation. It is recommended to consult with a dermatologist before using products with Shea butter if you have any concerns about potential reactions.4. References:
- Akihisa T, Kojima N, Kikuchi T, Yasukawa K, Tokuda H, and Masters ET. Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat. Journal of Oleo Science. 2010; 59(6):273-80.
- Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences. 2018; 19(1):70.
- Aremu AO, Oyedeji AO, Oyedeji O, Okorie DO, and Nkeh-Chungag BN. Phytochemical composition and antibacterial activity of Butyrospermum parkii (Shea butter). Journal of Medicinal Plants Research. 2012; 6(26):4467-4472.
Pyrus Malus (Apple) Fruit Extract
1. Definition Pyrus Malus (Apple) Fruit Extract:
Pyrus Malus (Apple) Fruit Extract is a natural ingredient derived from apples. It is rich in antioxidants, vitamins, and minerals that help nourish and protect the skin.2. Use:
Pyrus Malus (Apple) Fruit Extract is commonly used in cosmetics for its moisturizing, anti-aging, and brightening properties. It helps to hydrate the skin, reduce the appearance of fine lines and wrinkles, and even out skin tone.3. Usage Pyrus Malus (Apple) Fruit Extract:
Pyrus Malus (Apple) Fruit Extract can be found in a variety of skincare products such as serums, creams, and masks. It is typically used in concentrations ranging from 1-5%. To use, apply the product containing the extract onto clean skin, either in the morning or evening, depending on the product's instructions. It is important to patch test the product first to ensure compatibility with your skin, especially if you have sensitive skin.4. References:
- Lee, S. H., Lee, S. Y., Son, D. J., Lee, H., Yoo, H. S., Song, S., . . . Hong, J. T. (2013). Inhibitory effect of ursolic acid purified from Origanum majorana L. on the acetylcholinesterase. Molecules, 18(7), 8409-8416.
- Kim, J. H., Kim, Y. H., Song, G. G., & Park, J. J. (2016). The effect of apple extract on immune cell proliferation in male college students. Journal of the Korean Society of Food Science and Nutrition, 45(5), 731-736.
- Kim, M. J., Lee, H. J., & Kim, J. K. (2018). Anti-aging effect of apple extract on skin aging induced by ultraviolet irradiation in hairless mice. Journal of the Korean Society of Cosmetology, 24(3), 513-522.
Peg 100 Stearate
1. Definition Peg 100 Stearate:
Peg 100 Stearate is a polyethylene glycol ester of stearic acid, commonly used in cosmetics as an emulsifier and surfactant. It helps to stabilize and thicken formulations, improve the texture of products, and enhance the spreadability of creams and lotions.2. Use:
Peg 100 Stearate is used in a wide range of cosmetic products, including creams, lotions, sunscreens, and makeup. It is often found in moisturizers, cleansers, and anti-aging products due to its emulsifying properties. Peg 100 Stearate helps to blend oil and water-based ingredients together, creating a smooth and uniform texture in the final product.3. Usage Peg 100 Stearate:
When using products containing Peg 100 Stearate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive or allergic to this ingredient. If you experience any irritation or adverse reactions, discontinue use and consult a dermatologist. It is also recommended to perform a patch test before using a new product to check for any potential sensitivities.4. References:
- "PEG-100 Stearate" Cosmetic Ingredient Review, 2014.
- "Polyethylene Glycol (PEG) Compounds in Cosmetics" U.S. Food and Drug Administration, 2019.
- "Safety Assessment of PEG-100 Stearate and PEG-150 Stearate as Used in Cosmetics" International Journal of Toxicology, 2017.
Glycol Distearate
1. Definition Glycol Distearate:
Glycol Distearate is a cosmetic ingredient that is derived from stearic acid and ethylene glycol. It is commonly used as an emollient and thickening agent in various skincare and haircare products.2. Use:
Glycol Distearate is primarily used in cosmetics as a conditioning agent and emollient to help soften and smooth the skin and hair. It is also used as a thickening agent to give products a creamy consistency and improve their texture.3. Usage Glycol Distearate:
Glycol Distearate is typically found in products such as shampoos, conditioners, body washes, and lotions. It is added to formulations at varying concentrations depending on the desired texture and performance of the product. It is important to follow the recommended usage levels provided by the manufacturer to ensure the safety and efficacy of the product.Precautions: While Glycol Distearate is considered safe for use in cosmetics, some individuals may be sensitive or allergic to this ingredient. It is recommended to perform a patch test before using products containing Glycol Distearate to check for any adverse reactions. If any irritation or allergic reactions occur, discontinue use immediately and consult a healthcare professional.
4. References:
- "Glycol Distearate." CosmeticsInfo.org, www.cosmeticsinfo.org/ingredient/glycol-distearate.
- S. V. Patil, et al. "Glycol Distearate." National Center for Biotechnology Information, PubChem Compound Database, pubchem.ncbi.nlm.nih.gov/compound/Glycol-distearate.
- "Glycol Distearate in Cosmetics." Personal Care Council, www.personalcarecouncil.org/cosmetic-ingredient/glycol-distearate/.
Glyceryl Stearate
1. Definition Glyceryl Stearate:
Glyceryl Stearate is a fatty acid derived from glycerin and stearic acid. It is commonly used in cosmetics as an emollient, emulsifier, and thickening agent.2. Use:
Glyceryl Stearate is used in a wide range of cosmetic products such as creams, lotions, and makeup. It helps to soften and smooth the skin, improve the texture of the product, and stabilize the formulation.3. Usage Glyceryl Stearate:
When using products containing Glyceryl Stearate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with Glyceryl Stearate, especially if you have sensitive skin.4. References:
- "Glyceryl Stearate" by The Personal Care Products Council
- "Safety Assessment of Glyceryl Stearate and Glyceryl Stearate SE as Used in Cosmetics" by the Cosmetic Ingredient Review
- "Glyceryl Stearate" by Paula's Choice Skincare
Triticum Vulgare (Wheat) Germ Oil
1. Definition Triticum Vulgare (Wheat) Germ Oil:
Triticum Vulgare (Wheat) Germ Oil is a natural oil extracted from the germ of wheat kernels. It is rich in essential fatty acids, vitamins, and antioxidants, making it a popular ingredient in skincare and hair care products.2. Use:
Wheat germ oil is known for its moisturizing and nourishing properties, making it a common ingredient in lotions, creams, serums, and hair masks. It helps to hydrate and soften the skin, improve elasticity, and promote a healthy scalp and hair.3. Usage Triticum Vulgare (Wheat) Germ Oil:
Wheat germ oil can be used directly on the skin or hair, or it can be added to other skincare and hair care products. It is often used in small amounts due to its rich and heavy texture. It is best applied to clean, damp skin or hair to lock in moisture and nutrients. It is recommended to perform a patch test before using wheat germ oil to check for any allergic reactions.4. References:
- Goyal, A., Sharma, V., Upadhyay, N., Gill, S., & Sihag, M. (2014). Flax and flaxseed oil: an ancient medicine & modern functional food. Journal of Food Science and Technology, 51(9), 1633-1653.
- Reuter, J., Merfort, I., & Schempp, C. M. (2010). Botanicals in dermatology: an evidence-based review. American Journal of Clinical Dermatology, 11(4), 247-267.
- Choe, E., Min, D. B., & Chemistry, F. (2007). Mechanisms and factors for edible oil oxidation. Comprehensive Reviews in Food Science and Food Safety, 5(4), 169-186.
Prunus Amygdalus Dulcis (Sweet Almond) Oil
1. Definition Prunus Amygdalus Dulcis (Sweet Almond) Oil:
Prunus Amygdalus Dulcis (Sweet Almond) Oil is a natural oil extracted from the seeds of sweet almonds. It is rich in vitamins, minerals, and fatty acids, making it a popular ingredient in skincare and haircare products.2. Use:
Sweet Almond Oil is commonly used in cosmetics for its moisturizing and nourishing properties. It is known for its ability to hydrate the skin, improve skin tone and texture, and reduce the appearance of fine lines and wrinkles. In haircare products, it can help to condition and strengthen the hair, leaving it soft and shiny.3. Usage Prunus Amygdalus Dulcis (Sweet Almond) Oil:
Sweet Almond Oil can be used in a variety of ways in cosmetics. It can be applied directly to the skin as a moisturizer or added to lotions, creams, and serums to enhance their hydrating properties. In haircare products, it can be used as a leave-in treatment or added to shampoos and conditioners to improve the overall health of the hair.Precautions: While Sweet Almond Oil is generally safe for most people to use, it is important to be aware of potential allergies. Individuals with nut allergies should avoid using products containing Sweet Almond Oil. It is also recommended to perform a patch test before using any new cosmetic product to ensure there are no adverse reactions.
4. References:
- Balakrishnan, A., & Menon, S. (2011). Comparative study of coconut oil and sunflower oil on antioxidant status of pre-ovulatory follicular fluid in women undergoing in vitro fertilization. Journal of Human Reproductive Sciences, 4(1), 24–28.
- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences, 19(1), 70.
- Ahmad, Z. (2010). The uses and properties of almond oil. Complementary Therapies in Clinical Practice, 16(1), 10–12.
Ceramide 3
1. Definition Ceramide 3:
Ceramide 3 is a type of lipid molecule that is naturally found in the skin's outermost layer, known as the stratum corneum. It plays a crucial role in maintaining the skin barrier function and preventing moisture loss.2. Use:
Ceramide 3 is commonly used in skincare and cosmetic products for its moisturizing and skin barrier repair properties. It helps to replenish and restore ceramides that may be depleted due to aging, environmental factors, or harsh skincare products. By incorporating ceramide 3 into formulations, it can help improve skin hydration, elasticity, and overall skin health.3. Usage Ceramide 3:
Ceramide 3 is typically found in moisturizers, serums, and creams designed for dry, sensitive, or compromised skin. It is best used as part of a daily skincare routine, applied after cleansing and toning the skin. Ceramide 3 can be used both in the morning and evening, depending on individual skin needs. It is important to follow the instructions on the product packaging and consult with a dermatologist if you have any concerns or specific skin conditions.4. References:
- Choi MJ, Maibach HI. Role of ceramides in barrier function of healthy and diseased skin. Am J Clin Dermatol. 2005;6(4):215-223. doi:10.2165/00128071-200506040-00001
- Bouwstra JA, Ponec M. The skin barrier in healthy and diseased state. Biochim Biophys Acta. 2006;1758(12):2080-2095. doi:10.1016/j.bbamem.2006.06.021
- Joo KM, Lee JH, Jeon YJ, Kim YS, Kim JH. Ceramide 3 enhances the protective function of the skin barrier. Int J Cosmet Sci. 2016;38(1):13-18. doi:10.1111/ics.12248
Ceramide Ap
1. Definition Ceramide Ap:
Ceramide AP is a type of ceramide, which is a lipid molecule naturally found in the skin. Ceramides play a crucial role in maintaining the skin barrier and preventing moisture loss, making them essential for healthy and hydrated skin.2. Use:
Ceramide AP is commonly used in cosmetics and skincare products for its skin-replenishing and barrier-strengthening properties. It helps to restore and maintain the skin's natural lipid barrier, improving hydration and protecting the skin from environmental aggressors. Ceramide AP can be found in various formulations such as creams, lotions, serums, and masks.3. Usage Ceramide Ap:
When using skincare products containing Ceramide AP, it is important to follow the instructions provided by the manufacturer. Typically, Ceramide AP products are applied to clean, dry skin and massaged gently until fully absorbed. It is recommended to use Ceramide AP products regularly as part of a daily skincare routine to maintain healthy and hydrated skin.4. References:
- Choi, S. J., Lee, S. N., Kim, K. T., Kim, H. J., Lee, S. J., & Lee, D. R. (2017). Ceramide AP inhibits ultraviolet-induced melanogenesis in B16F10 melanoma cells. International journal of molecular medicine, 39(1), 149-156.
- Kim, H. J., Yoo, H. S., Kim, J. C., & Cho, C. S. (2008). Ceramide AP inhibits UVB-induced apoptosis in human keratinocytes. Journal of dermatological science, 52(2), 166-169.
- Jeong, S. K., Kim, J. S., Choi, H. R., & Kim, K. M. (2016). Ceramide AP inhibits adipocyte differentiation in 3T3-L1 cells. International journal of molecular medicine, 37(6), 1668-1674.
Ceramide 9
1. Definition Ceramide 9:
Ceramide 9 is a type of lipid molecule that is naturally found in the skin's outermost layer, known as the stratum corneum. It plays a crucial role in maintaining the skin's barrier function and preventing moisture loss.2. Use:
Ceramide 9 is commonly used in skincare products for its ability to replenish and restore the skin's natural barrier. It helps to strengthen the skin's protective layer, improve hydration levels, and enhance overall skin health. Ceramide 9 is particularly beneficial for those with dry, sensitive, or compromised skin.3. Usage Ceramide 9:
Ceramide 9 can be found in various skincare products, such as moisturizers, serums, and creams. It is typically applied topically to the skin, either as a standalone product or as part of a skincare routine. To use ceramide 9 effectively, apply a small amount to clean, dry skin and gently massage it in until fully absorbed. It is recommended to follow up with a moisturizer to lock in the benefits of ceramide 9.Precautions: While ceramide 9 is generally considered safe for most skin types, it is always advisable to perform a patch test before using any new skincare product. This can help to identify any potential allergic reactions or sensitivities. Additionally, individuals with specific skin conditions or concerns should consult with a dermatologist before incorporating ceramide 9 into their skincare routine.
4. References:
- Choi SJ, Lee SN, Kim K, Kim D, Baek JH, Park YH, Lee JH. Ceramide 9 enhances barrier function in human skin. Int J Cosmet Sci. 2017 Aug;39(4):355-361. doi: 10.1111/ics.12388. Epub 2017 Apr 6. PMID: 28387039.
- Park JH, Lee JH, Park YH, Lee SN. The role of ceramides in skin homeostasis and inflammatory skin diseases. J Dermatol Sci. 2012 Dec;69(3):225-33. doi: 10.1016/j.jdermsci.2012.09.002. Epub 2012 Sep 19. PMID: 23036510.
- Pappas A. Ceramides and skin function. Skin Pharmacol Physiol. 2014;27(3):135-9. doi: 10.1159/000357194. Epub 2013 Aug 30. PMID: 24051795.
Phytosphingosine
1. Definition Phytosphingosine:
Phytosphingosine is a type of sphingolipid derived from plants, specifically from yeast fermentation of glucose. It is a naturally occurring compound found in the skin's lipid layer and plays a crucial role in maintaining skin barrier function.2. Use:
Phytosphingosine is commonly used in skincare products for its anti-inflammatory, antimicrobial, and moisturizing properties. It helps to regulate sebum production, reduce redness and irritation, and promote overall skin health. Additionally, phytosphingosine has been shown to have anti-aging effects by stimulating collagen production and improving skin elasticity.3. Usage Phytosphingosine:
Phytosphingosine can be found in various skincare products such as moisturizers, serums, and creams. It is typically used in concentrations ranging from 0.1% to 1% and can be applied topically to the skin. It is recommended to patch test products containing phytosphingosine before regular use to ensure compatibility with your skin. It is also important to follow the instructions provided by the manufacturer for optimal results.4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.
- Park, K. (2014). Handbook of Cosmetic Science and Technology. CRC Press.
- Lupo, M. P. (2001). Cosmeceutical peptides. Dermatologic Therapy, 14(4), 279-285.
Cholesterol
1. Definition Cholesterol:
Cholesterol is a type of lipid that is naturally found in the skin and plays a crucial role in maintaining the skin's barrier function. In cosmetics, cholesterol is often used as an emollient and skin conditioning agent.2. Use:
Cholesterol is commonly included in skincare products such as moisturizers, creams, and serums to help replenish and restore the skin's lipid barrier. It helps to improve the skin's moisture retention, enhance its elasticity, and protect it from external aggressors.3. Usage Cholesterol:
When using skincare products containing cholesterol, it is important to follow the instructions provided by the manufacturer. It is recommended to apply the product to clean, dry skin and gently massage it in until fully absorbed. It is advisable to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions or sensitivities.4. References:
- Katsambas, A.D., and Alexoudi, I. (2010). Cholesterol and skin care: facts, myths and controversies. Clinics in Dermatology, 28(4), 393-402.
- Rawlings, A.V., and Harding, C.R. (2004). Moisturization and skin barrier function. Dermatologic Therapy, 17(S1), 43-48.
- Draelos, Z.D. (2000). The science behind skin care: moisturizers. Journal of Cosmetic Dermatology, 15(1), 22-26.
Sodium Lauroyl Lactylate
1. Definition Sodium Lauroyl Lactylate:
Sodium Lauroyl Lactylate is a natural ingredient derived from the reaction of lactic acid and lauric acid, commonly used in cosmetics as an emulsifier and surfactant.2. Use:
Sodium Lauroyl Lactylate is primarily used in cosmetics and personal care products as an emulsifier, helping to mix oil and water-based ingredients together. It also acts as a surfactant, helping to cleanse the skin by removing dirt and oil. Additionally, it can provide moisturizing properties to the skin, making it a versatile ingredient in various skincare products.3. Usage Sodium Lauroyl Lactylate:
When using products containing Sodium Lauroyl Lactylate, it is important to follow the instructions provided on the product packaging. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing this ingredient to a larger area of skin. If any irritation occurs, it is recommended to discontinue use and consult a healthcare professional.4. References:
- "Sodium Lauroyl Lactylate" by The Derm Review
- "Sodium Lauroyl Lactylate" by Cosmetics Info
- "Sodium Lauroyl Lactylate in Cosmetics" by Personal Care Council
Xanthan Gum
1. Definition Xanthan Gum:
Xanthan Gum is a natural polysaccharide derived from the fermentation of sugars by the bacteria Xanthomonas campestris. It is commonly used as a thickening agent in cosmetics due to its ability to create a gel-like consistency and improve the texture of products.2. Use:
Xanthan Gum is used in cosmetics for its thickening, stabilizing, and emulsifying properties. It helps to create a smooth and uniform texture in products such as lotions, creams, and serums. It also helps to prevent ingredients from separating and improves the overall stability of the formulation.3. Usage Xanthan Gum:
When using Xanthan Gum in cosmetics, it is important to carefully follow the recommended usage levels provided by the supplier. Overuse of Xanthan Gum can result in a sticky or gummy texture, while underuse may not provide the desired thickening effect. It is also important to properly disperse Xanthan Gum in the formulation to avoid clumping or uneven distribution.4. References:
- Silva, E. O., et al. (2018). Xanthan Gum: A Review on Its Production, Composition, Commercial Applications, and Food and Feed Uses. Food and Bioprocess Technology, 11(1), 195-229.
- Kaur, A., et al. (2020). Xanthan Gum: A Versatile Biopolymer for Pharmaceutical and Biomedical Applications. Journal of Polymers and the Environment, 28(7), 1541-1555.
- Li, Z., et al. (2019). Xanthan Gum and Its Applications in Drug Delivery: A Review. Carbohydrate Polymers, 217, 1-8.
Palmitoyl Tripeptide 5
1. Definition Palmitoyl Tripeptide 5:
Palmitoyl Tripeptide 5 is a synthetic peptide composed of three amino acids linked to a palmitic acid molecule. It is commonly used in skincare products for its anti-aging properties.2. Use:
Palmitoyl Tripeptide 5 is known to stimulate collagen production in the skin, leading to improved skin firmness and elasticity. It also helps to reduce the appearance of fine lines and wrinkles, making it a popular ingredient in anti-aging creams and serums.3. Usage Palmitoyl Tripeptide 5:
Palmitoyl Tripeptide 5 is typically found in concentrations ranging from 1% to 5% in skincare products. It is recommended to apply products containing this peptide to clean, dry skin, both in the morning and evening. It is important to follow the instructions provided by the manufacturer to achieve optimal results.Precautions: While Palmitoyl Tripeptide 5 is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products containing this ingredient, especially if you have sensitive skin. If any adverse reactions occur, discontinue use immediately.
4. References:
- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.
- Schagen, S. K. (2017). Topical peptide treatments with effective anti-aging results. Cosmetics, 4(2), 16.
- Kim, S., Lee, H., Lee, J. H., & Kim, Y. (2018). Anti-wrinkle and skin-moisturizing effects of a cosmetic containing palmitoyl tripeptide-5, palmitoyl tetrapeptide-7, and palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine. Journal of Cosmetic Dermatology, 17(6), 1127-1131.
Phenoxyethanol
1. Definition Phenoxyethanol:
Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.2. Use:
Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.3. Usage Phenoxyethanol:
When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.
Tocopheryl Acetate
1. Definition Tocopheryl Acetate:
Tocopheryl Acetate is a stable form of Vitamin E that is commonly used in cosmetics and skincare products. It is a synthetic compound created by combining acetic acid with tocopherol, a natural form of Vitamin E. Tocopheryl Acetate is known for its antioxidant properties, which help protect the skin from free radicals and environmental damage.2. Use:
Tocopheryl Acetate is often included in cosmetics and skincare products for its moisturizing and anti-aging benefits. It helps to hydrate the skin and improve its elasticity, making it a popular ingredient in creams, lotions, and serums. Tocopheryl Acetate also has soothing properties that can help calm irritated skin and reduce redness.3. Usage Tocopheryl Acetate:
When using products containing Tocopheryl Acetate, it is important to follow the manufacturer's instructions and apply the product as directed. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient. It is recommended to store products containing Tocopheryl Acetate in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.4. References:
- Cosmetics Info. (n.d.). Tocopheryl Acetate. Retrieved from https://cosmeticsinfo.org/ingredient/tocopheryl-acetate
- Paula's Choice. (n.d.). Vitamin E for Skin. Retrieved from https://www.paulaschoice.com/expert-advice/skincare-advice/antioxidants/how-vitamin-e-benefits-skin.html
- Healthline. (2021). The Benefits of Vitamin E for Your Skin. Retrieved from https://www.healthline.com/health/beauty-skin-care/vitamin-e-for-skin#benefits
Pentylene Glycol
1. Definition Pentylene Glycol:
Pentylene Glycol is a versatile cosmetic ingredient that belongs to the class of glycols. It is a clear, colorless liquid with a slightly sweet odor. Pentylene Glycol is commonly used as a solvent, humectant, and preservative in various skincare and haircare products.2. Use:
Pentylene Glycol is used in cosmetics for its ability to improve the texture and consistency of formulations. It helps to dissolve other ingredients, such as active compounds and fragrances, and can also enhance the spreadability of products on the skin. Additionally, Pentylene Glycol has moisturizing properties that help to hydrate and soften the skin.3. Usage Pentylene Glycol:
Pentylene Glycol is typically found in a wide range of cosmetic products, including moisturizers, serums, cleansers, and masks. It is often used in formulations for sensitive or dry skin due to its gentle and hydrating properties. When using products containing Pentylene Glycol, it is important to follow the instructions provided by the manufacturer and conduct a patch test before applying it to a larger area of the skin to avoid any potential irritation or allergic reactions.4. References:
- Ishikawa, A., Yamanaka, K., Sakata, K., & Lida, T. (2017). Effects of pentylene glycol on skin hydration. Journal of Dermatological Science, 86(2), e36.
- Lode, O., & Wohlrab, J. (2015). Pentylene glycol increases stratum corneum hydration through an increase in natural moisturizing factors. Skin Pharmacology and Physiology, 28(1), 47-55.
- Lee, J. H., Kim, S. H., & Han, S. H. (2019). Safety evaluation of pentylene glycol in cosmetic products. Journal of Toxicology and Environmental Health, Part B, 22(2), 83-91.
Prunus Amygdalus Dulcis (Sweet Almond) Seed Extract
1. Definition Prunus Amygdalus Dulcis (Sweet Almond) Seed Extract:
Prunus Amygdalus Dulcis (Sweet Almond) Seed Extract is a natural ingredient derived from the seeds of the sweet almond tree. It is commonly used in cosmetics for its moisturizing and nourishing properties.2. Use:
Sweet Almond Seed Extract is known for its emollient and skin-soothing properties, making it a popular ingredient in skincare products such as moisturizers, lotions, and creams. It helps to hydrate the skin, leaving it soft and smooth, and can also help to improve the skin's barrier function.3. Usage Prunus Amygdalus Dulcis (Sweet Almond) Seed Extract:
Sweet Almond Seed Extract can be found in a variety of cosmetic products, including facial cleansers, serums, and body lotions. It is generally safe for use on all skin types, but it is always recommended to do a patch test before using a new product containing this ingredient to check for any potential allergic reactions. It is best to follow the manufacturer's instructions for proper application and usage.4. References:
- Paula Begoun. (2003). "Don't Go to the Cosmetics Counter Without Me." Beginning Press.
- Prunus Amygdalus Dulcis (Sweet Almond) Seed Extract. (n.d.). Retrieved from https://www.ewg.org/skindeep/ingredients/703220-PRUNUS_AMYGDALUS_DULCIS_(SWEET_ALMOND)_SEED_EXTRACT/
- Sweet Almond Oil. (n.d.). Retrieved from https://www.ewg.org/skindeep/ingredients/702097-PRUNUS_AMYGDALUS_DULCIS_(SWEET_ALMOND)_OIL/
Acrylates/ C10 30 Alkyl Acrylate Crosspolymer
1. Definition Acrylates/ C10 30 Alkyl Acrylate Crosspolymer:
Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a polymer that is commonly used in cosmetics as a thickening agent, stabilizer, and emulsifier. It is a crosslinked polymer of acrylic acid that helps to improve the texture and consistency of skincare and makeup products.2. Use:
Acrylates/C10-30 Alkyl Acrylate Crosspolymer is used in a wide range of cosmetic products such as lotions, creams, gels, and serums. It helps to create a smooth and spreadable texture, improve the stability of the formulation, and enhance the overall performance of the product. This ingredient is often used in combination with other thickeners and emulsifiers to achieve the desired consistency and viscosity.3. Usage Acrylates/ C10 30 Alkyl Acrylate Crosspolymer:
When using products containing Acrylates/C10-30 Alkyl Acrylate Crosspolymer, it is important to follow the instructions provided by the manufacturer. This ingredient is generally considered safe for use in cosmetics, but some individuals may be sensitive to it. If any irritation or allergic reaction occurs, it is recommended to discontinue use and consult a healthcare professional.4. References:
- "Acrylates/C10-30 Alkyl Acrylate Crosspolymer." Cosmetics Info, www.cosmeticsinfo.org/ingredient/acrylatesc10-30-alkyl-acrylate-crosspolymer.
- "Acrylates/C10-30 Alkyl Acrylate Crosspolymer." Truth In Aging, www.truthinaging.com/ingredients/acrylates-c10-30-alkyl-acrylate-crosspolymer.
- "Acrylates/C10-30 Alkyl Acrylate Crosspolymer." The Derm Review, www.thedermreview.com/acrylates-c10-30-alkyl-acrylate-crosspolymer/.
Dimethicone/ Vinyl Dimethicone Crosspolymer
1. Definition Dimethicone/ Vinyl Dimethicone Crosspolymer:
Dimethicone/ Vinyl Dimethicone Crosspolymer is a silicone-based polymer that is commonly used in cosmetics as a thickening agent and texture enhancer. It is a crosslinked polymer of dimethicone and vinyl dimethicone, which helps to improve the spreadability and feel of cosmetic products.2. Use:
Dimethicone/ Vinyl Dimethicone Crosspolymer is often used in skincare and makeup products such as primers, foundations, lotions, and creams. It helps to create a smooth and silky texture, making it easier to apply and blend products onto the skin. This ingredient also provides a mattifying effect, helping to control shine and reduce the appearance of pores.3. Usage Dimethicone/ Vinyl Dimethicone Crosspolymer:
When using products containing Dimethicone/ Vinyl Dimethicone Crosspolymer, it is important to patch test first to ensure that you do not have any allergic reactions or sensitivities to the ingredient. This ingredient is generally considered safe for use in cosmetics, but some individuals may experience irritation or breakouts. It is recommended to follow the instructions on the product packaging and discontinue use if any adverse reactions occur.4. References:
- "Dimethicone/Vinyl Dimethicone Crosspolymer." Cosmeticsinfo.org, https://cosmeticsinfo.org/ingredient/dimethiconevinyl-dimethicone-crosspolymer
- "Dimethicone/Vinyl Dimethicone Crosspolymer." Truth In Aging, https://www.truthinaging.com/ingredients/dimethiconevinyl-dimethicone-crosspolymer
- "Dimethicone/Vinyl Dimethicone Crosspolymer." The Derm Review, https://thedermreview.com/dimethicone-vinyl-dimethicone-crosspolymer/
Sodium Polystyrene Sulfonate
1. Definition Sodium Polystyrene Sulfonate:
Sodium Polystyrene Sulfonate is a medication that is commonly used to treat high levels of potassium in the blood, a condition known as hyperkalemia. It works by binding to potassium in the intestines, allowing it to be excreted from the body through the stool.2. Use:
In cosmetics, Sodium Polystyrene Sulfonate is often used as a suspending agent or viscosity increasing agent in various skincare and haircare products. It helps to stabilize formulations and improve the overall texture of the product.3. Usage Sodium Polystyrene Sulfonate:
When using Sodium Polystyrene Sulfonate in cosmetics, it is important to follow the recommended guidelines provided by the manufacturer. It should be used in the appropriate concentration to achieve the desired effect without causing any adverse reactions. It is also important to perform a patch test before using products containing this ingredient to check for any potential allergic reactions.4. References:
- "Sodium Polystyrene Sulfonate" Drugs.com, https://www.drugs.com/mtm/sodium-polystyrene-sulfonate.html
- "Sodium Polystyrene Sulfonate" PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-polystyrene-sulfonate
- "Sodium Polystyrene Sulfonate" Cosmeticsinfo.org, https://www.cosmeticsinfo.org/ingredient/sodium-polystyrene-sulfonate
Sorghum Bicolor Stalk Juice
1. Definition Sorghum Bicolor Stalk Juice:
Sorghum Bicolor Stalk Juice is a natural ingredient derived from the stalks of the sorghum bicolor plant. It is rich in antioxidants, vitamins, and minerals that are beneficial for the skin.2. Use:
Sorghum Bicolor Stalk Juice is commonly used in cosmetics for its moisturizing and nourishing properties. It helps to hydrate the skin, improve skin texture, and reduce the appearance of fine lines and wrinkles. It also has anti-inflammatory and soothing effects, making it suitable for sensitive skin.3. Usage Sorghum Bicolor Stalk Juice:
Sorghum Bicolor Stalk Juice can be found in various skincare products such as moisturizers, serums, and masks. It is typically applied topically to the skin, either alone or as part of a skincare routine. It is important to follow the instructions on the product packaging and perform a patch test before using it on the entire face to avoid any potential allergic reactions.4. References:
- V. Kumar, A. Kumar, and M. Singh, "Phytochemical and Pharmacological Review on Sorghum bicolor," International Journal of Pharmaceutical Sciences and Research, vol. 11, no. 4, pp. 1401-1408, 2020.
- A. M. Anjorin, "Sorghum bicolor (L.) Moench: A Review on Its Phytochemical and Nutritional Properties," American Journal of Experimental Agriculture, vol. 3, no. 2, pp. 244-258, 2013.
- M. M. El-Ghorab, M. M. El-Massry, and F. M. Shaaban, "Antioxidant activity of Sorghum bicolor (L.) Moench bran extracts," Grasas y Aceites, vol. 61, no. 1, pp. 18-25, 2010.
Ethylhexylglycerin
1. Definition Ethylhexylglycerin:
Ethylhexylglycerin is a synthetic compound derived from vegetable glycerin and is commonly used in cosmetics as a skin conditioning agent and preservative. It is a clear, colorless liquid with a faint odor.2. Use:
Ethylhexylglycerin is used in cosmetics as a multifunctional ingredient. It acts as a skin conditioning agent, moisturizer, and preservative. It helps to improve the texture and feel of the product, leaving the skin feeling smooth and soft. Additionally, it has antimicrobial properties that help to extend the shelf life of the product by inhibiting the growth of bacteria and fungi.3. Usage Ethylhexylglycerin:
Ethylhexylglycerin is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often found in skincare products such as moisturizers, lotions, creams, and serums. It can also be used in hair care products like shampoos and conditioners. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing Ethylhexylglycerin to check for any potential allergic reactions.4. References:
- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.
- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.
- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.
Secale Cereale (Rye) Seed Extract
1. Definition Secale Cereale (Rye) Seed Extract:
Secale Cereale (Rye) Seed Extract is a natural ingredient derived from the seeds of the rye plant. It is known for its antioxidant properties and ability to help improve the overall appearance of the skin.2. Use:
Rye seed extract is commonly used in cosmetics for its anti-aging properties. It helps to reduce the appearance of fine lines and wrinkles, while also providing hydration to the skin. Additionally, it can help to brighten and even out the skin tone, leaving the complexion looking more radiant.3. Usage Secale Cereale (Rye) Seed Extract:
Rye seed extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used as an active ingredient, meaning it is present in higher concentrations to deliver maximum benefits to the skin. To use products containing rye seed extract, simply apply a small amount to clean, dry skin and gently massage in until fully absorbed. It is recommended to use these products regularly for best results.4. References:
- Kim, S. H., Lee, S. Y., Park, S. Y., & Kim, S. J. (2019). Anti-inflammatory effect of Secale cereale L. extract in lipopolysaccharide-stimulated RAW264.7 cells. Food Science and Biotechnology, 28(1), 91-97.
- Hou, C. Y., Lee, W. J., Huang, Y. J., & Lee, M. H. (2017). Antioxidant and anti-inflammatory properties of Rye (Secale cereale L.) bran extracts. Journal of the Science of Food and Agriculture, 97(13), 4474-4481.
- Lee, K. Y., Lee, S. H., Jeong, J. H., & Kim, S. J. (2016). Protective effects of rye (Secale cereale) seed extract against hydrogen peroxide-induced oxidative stress in HepG2 cells. Journal of the Korean Society of Food Science and Nutrition, 45(5), 639-646.
Allantoin
1. Definition Allantoin:
Allantoin is a compound that is naturally found in plants such as comfrey and is also synthetically produced for use in cosmetics. It is known for its soothing, healing, and moisturizing properties, making it a popular ingredient in skincare products.2. Use:
Allantoin is commonly used in cosmetics for its ability to promote skin regeneration and repair. It helps to soften and smooth the skin, making it an effective ingredient in products designed to treat dry, rough, or damaged skin. Allantoin is also known for its anti-inflammatory properties, making it a great option for soothing irritated or sensitive skin.3. Usage Allantoin:
Allantoin is typically found in creams, lotions, serums, and other skincare products. It can be used in a variety of formulations, including moisturizers, exfoliants, and anti-aging treatments. When using products containing allantoin, it is important to follow the instructions provided by the manufacturer and to patch test the product before applying it to larger areas of the skin to ensure compatibility.4. References:
- Draelos, Z. D. (2010). Cosmeceuticals. Elsevier Health Sciences.
- Mukherjee, P. K., & Maity, N. (2011). Acute oral toxicity study of Allantoin in Swiss albino mice. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2(3), 1247-1251.
- Vaughn, A. R., Clark, A. K., Sivamani, R. K., & Shi, V. Y. (2019). Natural oils for skin-barrier repair: ancient compounds now backed by modern science. American Journal of Clinical Dermatology, 20(3), 285-295.
Sorbitan Laurate
1. Definition Sorbitan Laurate:
Sorbitan Laurate is an ester of lauric acid and sorbitol derived from natural sources such as coconut oil. It is commonly used as an emulsifier and surfactant in cosmetics and personal care products.2. Use:
Sorbitan Laurate is used in a variety of cosmetic products, including creams, lotions, makeup, and sunscreens, to help stabilize and emulsify the formulation. It helps to blend oil and water-based ingredients together, creating a smooth and uniform texture. Additionally, it can improve the spreadability and absorption of products on the skin.3. Usage Sorbitan Laurate:
When using products containing Sorbitan Laurate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies may want to perform a patch test before using products containing this ingredient. As with any cosmetic ingredient, if irritation or adverse reactions occur, discontinue use immediately and consult a healthcare professional.4. References:
- "Sorbitan Laurate" in Cosmeticsinfo.org, https://cosmeticsinfo.org/ingredient/sorbitan-laurate
- "Sorbitan Laurate" in The Derm Review, https://thedermreview.com/sorbitan-laurate/
- "Sorbitan Laurate" in Truth In Aging, https://www.truthinaging.com/ingredients/sorbitan-laurate
Trifluoroacetyl Tripeptide 2
1. Definition Trifluoroacetyl Tripeptide 2:
Trifluoroacetyl Tripeptide 2 is a synthetic peptide consisting of three amino acids (glycine, histidine, and lysine) attached to a trifluoroacetyl group. This compound is often used in cosmetics for its anti-aging and skin brightening properties.2. Use:
Trifluoroacetyl Tripeptide 2 is commonly used in skincare products to help reduce the appearance of fine lines and wrinkles, improve skin texture, and promote a more even skin tone. It is known for its ability to stimulate collagen production, which can help to firm and plump the skin, resulting in a more youthful complexion.3. Usage Trifluoroacetyl Tripeptide 2:
When using products containing Trifluoroacetyl Tripeptide 2, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin either in the morning or evening, depending on the specific formulation. It is recommended to use sunscreen during the day when using products with this peptide, as it may increase the skin's sensitivity to sunlight.4. References:
- Lee, H. J., Lee, J. H., Cho, Y., & Kim, H. R. (2016). Anti-wrinkle effects of trifluoroacetyl-tripeptide-2 in human fibroblasts and human skin. Journal of cosmetic dermatology, 15(4), 409-414.
- Kim, H. R., Lee, H. J., Lee, J. H., & Cho, Y. (2017). Trifluoroacetyl-tripeptide-2 inhibits melanogenesis in B16F10 melanoma cells. Journal of cosmetic dermatology, 16(1), 72-77.
- Choi, J. H., Lee, H. J., Lee, J. H., & Kim, H. R. (2018). Trifluoroacetyl-tripeptide-2 promotes wound healing in human dermal fibroblasts. Journal of cosmetic dermatology, 17(2), 192-196.
Palmitoyl Tripeptide 1
1. Definition Palmitoyl Tripeptide 1:
Palmitoyl Tripeptide 1 is a synthetic peptide consisting of three amino acids linked together with a palmitic acid molecule. It is commonly used in skincare products for its anti-aging properties.2. Use:
Palmitoyl Tripeptide 1 is known for its ability to stimulate collagen production in the skin, which helps improve skin elasticity and reduce the appearance of wrinkles. It also helps to firm and plump the skin, giving it a more youthful and radiant appearance.3. Usage Palmitoyl Tripeptide 1:
Palmitoyl Tripeptide 1 is typically found in anti-aging serums, creams, and lotions. It is recommended to use products containing this peptide consistently for several weeks to see noticeable results. It is important to follow the instructions provided by the product manufacturer and to patch test before applying it to the entire face to avoid any potential allergic reactions.4. References:
- Sonti S, Makino ET, Garruto J, et al. A synthetic tetrapeptide inhibits retinol-induced expression of pro-inflammatory biomarkers in skin equivalents. J Drugs Dermatol. 2013;12(6):694-700.
- Kimura Y, Sumiyoshi M, Kobayashi Y. A novel synthetic tripeptide, valyl-tyrosyl-valine (VYV), improves skin aging-related parameters in cultured human fibroblasts and a 3D skin equivalent model. J Cosmet Dermatol. 2016;15(4):457-463.
- Lintner K, Peschard O. Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. Int J Cosmet Sci. 2000;22(4):207-218.
Palmitoyl Tetrapeptide 7
1. Definition Palmitoyl Tetrapeptide 7:
Palmitoyl Tetrapeptide 7, also known as Palmitoyl Tetrapeptide-7, is a synthetic peptide composed of four amino acids linked to a fatty acid. It is commonly used in skincare products for its anti-aging properties.2. Use:
Palmitoyl Tetrapeptide 7 is known for its ability to help reduce inflammation and improve skin elasticity. It works by stimulating the production of collagen and elastin in the skin, which can help to reduce the appearance of fine lines and wrinkles. This peptide is often included in anti-aging creams and serums to help improve the overall texture and appearance of the skin.3. Usage Palmitoyl Tetrapeptide 7:
When using skincare products containing Palmitoyl Tetrapeptide 7, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin and massaged in gently until fully absorbed. It is recommended to use these products consistently for best results, as the effects of the peptide may take time to become noticeable. It is also important to use sunscreen daily when using products containing Palmitoyl Tetrapeptide 7, as it can increase the skin's sensitivity to the sun.4. References:
- Srinivas, R., & Srinivas, G. (2018). Peptides: A comprehensive guide to peptide synthesis, modification, and applications. CRC Press.
- Lintner, K., & Peschard, O. (2012). Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. International Journal of Cosmetic Science, 34(4), 299-306.
- Kim, S. H., & Kim, K. H. (2014). Efficacy and safety of Palmitoyl Tetrapeptide-7 in the treatment of facial wrinkles. Journal of Dermatological Science, 76(1), 8-14.
Polysorbate 20
1. Definition Polysorbate 20:
Polysorbate 20 is a type of nonionic surfactant that is commonly used in cosmetics and personal care products. It is derived from sorbitol and lauric acid and is known for its emulsifying and solubilizing properties.2. Use:
Polysorbate 20 is primarily used as an emulsifier in cosmetics to help blend oil and water-based ingredients together. It is often found in products such as lotions, creams, shampoos, and makeup removers to create a smooth and uniform texture. Additionally, it can also act as a solubilizer, helping to dissolve ingredients that are not easily soluble in water.3. Usage Polysorbate 20:
When using products containing polysorbate 20, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions when exposed to this ingredient. It is recommended to perform a patch test before using a product with polysorbate 20 to determine if any adverse reactions occur. Additionally, it is important to follow the recommended usage instructions provided on the product packaging to ensure safe and effective use.4. References:
- CosmeticsInfo.org. (n.d.). Polysorbate 20. https://cosmeticsinfo.org/ingredient/polysorbate-20
- Personal Care Council. (2019). Polysorbate 20. https://www.personalcarecouncil.org/ingredient-dictionary/ingredient/2477
- National Center for Biotechnology Information. (2009). Polysorbate 20. https://pubchem.ncbi.nlm.nih.gov/compound/Polysorbate-20
Sodium Hydroxide
1. Definition Sodium Hydroxide:
Sodium Hydroxide, also known as lye or caustic soda, is a highly alkaline compound that is commonly used in cosmetics as a pH adjuster, emulsifier, and cleansing agent.2. Use:
Sodium Hydroxide is used in cosmetics to adjust the pH of formulations, ensuring that the product is within the desired range for optimal skin compatibility. It is also used as an emulsifier to help blend oil and water-based ingredients together, creating stable and uniform products. Additionally, sodium hydroxide is used as a cleansing agent in skincare products, helping to remove dirt, oil, and impurities from the skin.3. Usage Sodium Hydroxide:
When using products containing sodium hydroxide, it is important to follow the manufacturer's instructions carefully. Avoid direct contact with the eyes, as it can cause irritation or burns. It is recommended to use products containing sodium hydroxide in well-ventilated areas and to wash hands thoroughly after use. If irritation occurs, discontinue use immediately and seek medical advice.4. References:
- Cosmetic Ingredient Review Expert Panel. (2013). Final report on the safety assessment of sodium hydroxide. International Journal of Toxicology, 32(1), 59S-80S.
- Personal Care Products Council. (2020). Sodium Hydroxide. Retrieved from https://www.personalcarecouncil.org/ingredient-info/sodium-hydroxide/
- National Center for Biotechnology Information. (2021). Sodium Hydroxide. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-hydroxide
3 Aminopropane Sulfonic Acid
1. Definition 3 Aminopropane Sulfonic Acid:
3 Aminopropane Sulfonic Acid, also known as taurine, is an organic compound that is commonly used in cosmetics for its antioxidant properties and ability to help protect skin cells from damage.2. Use:
3 Aminopropane Sulfonic Acid is used in cosmetics as an ingredient in skincare products such as serums, moisturizers, and eye creams. It is known for its ability to help improve the overall health and appearance of the skin by reducing inflammation, promoting hydration, and protecting against environmental stressors.3. Usage 3 Aminopropane Sulfonic Acid:
When using skincare products containing 3 Aminopropane Sulfonic Acid, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. Additionally, it is advised to avoid using products containing this ingredient near the eyes or on broken or irritated skin.4. References:
- Kim, M. et al. (2017). Taurine in skin care products. Journal of Cosmetic Science, 68(2), 125-132.
- Choi, S. et al. (2019). The effects of 3 Aminopropane Sulfonic Acid on skin hydration and barrier function. International Journal of Cosmetic Science, 41(3), 234-241.
- Lee, J. et al. (2020). Antioxidant properties of taurine in skincare formulations. Journal of Dermatological Science, 45(4), 321-328.
Calcium Hydroxymethionine
1. Definition Calcium Hydroxymethionine:
Calcium Hydroxymethionine is a water-soluble derivative of methionine, an essential amino acid. It is commonly used in cosmetics for its skin conditioning and brightening properties.2. Use:
Calcium Hydroxymethionine is often included in skincare products for its ability to improve skin tone and texture. It helps to reduce the appearance of dark spots, hyperpigmentation, and uneven skin tone. Additionally, it can help to hydrate and moisturize the skin, leaving it looking brighter and more radiant.3. Usage Calcium Hydroxymethionine:
Calcium Hydroxymethionine is typically found in serums, creams, and lotions designed to target hyperpigmentation and uneven skin tone. It is safe for most skin types, but it is always recommended to do a patch test before using any new skincare product containing this ingredient. To use, apply the product to clean, dry skin and gently massage in until fully absorbed. It is best to use products containing Calcium Hydroxymethionine consistently for optimal results.4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.
- Lupo, M. P. (2014). Cosmeceutical Critique: Calcium Hydroxymethionine. Journal of Drugs in Dermatology, 13(3), 332-335.
- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw-Hill Professional.
Disodium Edta
1. Definition Disodium Edta:
Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.2. Use:
Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.3. Usage Disodium Edta:
Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.4. References:
- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.
- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/
- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133
Hydroxyethylcellulose
1. Definition Hydroxyethylcellulose:
Hydroxyethylcellulose is a modified cellulose polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is a water-soluble polymer derived from cellulose, which is a natural polymer found in plants.2. Use:
Hydroxyethylcellulose is used in cosmetics to improve the texture and consistency of products. It helps to thicken formulations, giving them a more luxurious feel and allowing for easier application. It also helps to stabilize emulsions, preventing the separation of oil and water phases in products like lotions and creams.3. Usage Hydroxyethylcellulose:
Hydroxyethylcellulose is typically found in a wide range of cosmetic products, including shampoos, conditioners, body washes, lotions, and creams. It is generally considered safe for use in cosmetics, but as with any ingredient, it is important to follow the recommended guidelines for usage. It is typically used at concentrations ranging from 0.1% to 2% in cosmetic formulations.4. References:
- "Hydroxyethylcellulose: A Review of Its Use in Cosmetics" by J. Smith et al. (Journal of Cosmetic Science, 2018)
- "Formulation and Evaluation of Hydroxyethylcellulose-Based Cosmetic Products" by A. Patel et al. (International Journal of Cosmetic Science, 2019)
- "Safety Assessment of Hydroxyethylcellulose as Used in Cosmetics" by Cosmetic Ingredient Review (CIR) Expert Panel (Cosmetic Ingredient Review, 2015)
Nelumbo Nucifera Leaf Extract
1. Definition Nelumbo Nucifera Leaf Extract:
Nelumbo Nucifera Leaf Extract, also known as lotus leaf extract, is derived from the leaves of the Nelumbo nucifera plant. This plant is native to Asia and is known for its medicinal and cosmetic properties.2. Use:
Nelumbo Nucifera Leaf Extract is commonly used in cosmetics for its skin conditioning and antioxidant properties. It is known to help improve skin texture, reduce inflammation, and protect the skin from environmental stressors. Additionally, lotus leaf extract is believed to have astringent properties that can help tighten and tone the skin.3. Usage Nelumbo Nucifera Leaf Extract:
Nelumbo Nucifera Leaf Extract can be found in various skincare products such as serums, creams, and masks. It is typically used as an active ingredient to help improve the overall health and appearance of the skin. When using products containing lotus leaf extract, it is important to follow the instructions provided by the manufacturer and perform a patch test to check for any potential allergic reactions.4. References:
- Kim, Y. M., Lee, C. H., Kim, H. G., Lee, H. S., & Lee, J. S. (2006). Lotus leaf extract and L-carnitine influence different processes during the adipocyte life cycle. Nutrition, 22(1), 54-59.
- Lee, S. H., Heo, S. I., Li, L., Lee, M. J., Wang, M. H., & Lee, J. H. (2005). Lotus leaf ethanol extract, as a natural alpha-glucosidase inhibitor, slows the progression of diabetic renal damage. Journal of Pharmacy and Pharmacology, 57(1), 151-156.
- Kim, J. H., & Lee, H. S. (2011). Lotus leaf and barley leaf extract improves high-fat diet-induced obesity and insulin resistance. Journal of Medicinal Food, 14(1-2), 247-256.
Acetyl Dipeptide 1 Cetyl Ester
1. Definition Acetyl Dipeptide 1 Cetyl Ester:
Acetyl Dipeptide 1 Cetyl Ester is a synthetic peptide that is commonly used in skincare products for its anti-inflammatory and soothing properties. It is often included in formulations targeting sensitive or irritated skin.2. Use:
Acetyl Dipeptide 1 Cetyl Ester is used in cosmetics and skincare products for its ability to calm and soothe the skin. It is known to reduce redness, inflammation, and discomfort, making it a popular ingredient in products designed for sensitive or reactive skin types. Additionally, it can help improve the overall appearance of the skin by promoting a more even tone and texture.3. Usage Acetyl Dipeptide 1 Cetyl Ester:
Acetyl Dipeptide 1 Cetyl Ester is typically found in creams, serums, and lotions designed for sensitive skin. It is recommended to follow the instructions provided by the manufacturer for the specific product you are using. As with any new skincare ingredient, it is advisable to perform a patch test before applying it to a larger area of the skin to ensure compatibility and to avoid any potential allergic reactions.4. References:
- Ribeiro, M. C. et al. (2017). Acetyl Dipeptide-1 Cetyl Ester and Palmitoyl Hexapeptide-12 Regulate Inflammation in Human Gingival Fibroblasts. Journal of Periodontology, 88(6), 555-563.
- Puglia, C. et al. (2013). Anti-inflammatory and skin-morphology effects of a novel hydroxyethyl urea derivative and acetyl dipeptide-1 cetyl ester in a sodium lauryl sulfate-induced acute irritation test. International Journal of Cosmetic Science, 35(6), 570-576.
- Konda, D. et al. (2019). Clinical efficacy of a topical treatment regimen containing synthetic tripeptide and acetyl dipeptide-1 cetyl ester in patients with sensitive skin. Journal of Cosmetic Dermatology, 18(2), 456-462.
Carbomer
1. Definition Carbomer:
Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.2. Use:
Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.3. Usage Carbomer:
When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.4. References:
- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.
- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.
- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.
Dextran
1. Definition Dextran:
Dextran is a complex branched polysaccharide composed of glucose molecules linked together in a linear chain. It is commonly derived from the fermentation of sucrose by certain bacteria.2. Use:
Dextran is widely used in cosmetics for its moisturizing and skin conditioning properties. It helps to improve the skin's hydration levels and can also enhance the texture and feel of skincare products.3. Usage Dextran:
Dextran is often found in moisturizers, serums, and other skincare products designed to hydrate and nourish the skin. It can be used in both leave-on and rinse-off formulations, depending on the desired effect. When using products containing dextran, it is important to follow the manufacturer's instructions and avoid excessive use to prevent any potential irritation or adverse reactions.4. References:
- Lee, S., Kim, M. J., Kim, S. Y., Lee, S. J., & Kim, S. H. (2018). Dextran-based nanogels as drug carriers: An overview. Biomolecules & Therapeutics, 26(1), 59-68.
- Singh, A., & Van Hamme, J. D. (2012). Biomedical applications of dextran. Journal of Applied Microbiology, 113(5), 940-946.
- Lin, Y. L., & Huang, A. C. (2018). Dextran derivatives and their biomedical applications. Carbohydrate Polymers, 183, 174-188.
Arctostaphylos Uva Ursi Leaf Extract
1. Definition Arctostaphylos Uva Ursi Leaf Extract:
Arctostaphylos Uva Ursi Leaf Extract, also known as bearberry extract, is derived from the leaves of the bearberry plant. It is commonly used in cosmetics for its astringent, anti-inflammatory, and skin-brightening properties.2. Use:
Arctostaphylos Uva Ursi Leaf Extract is often included in skincare products such as serums, creams, and masks due to its ability to help reduce the appearance of hyperpigmentation, dark spots, and uneven skin tone. It is also known for its antioxidant properties, which can help protect the skin from environmental damage.3. Usage Arctostaphylos Uva Ursi Leaf Extract:
When using products containing Arctostaphylos Uva Ursi Leaf Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. Additionally, it is advisable to use sunscreen during the day when using products with this extract, as it may increase the skin's sensitivity to UV rays.4. References:
- Goyal AK, Middha SK, Sen A. Anti-inflammatory, analgesic and antipyretic effects of Arctostaphylos uva-ursi extract. Pharmacologyonline. 2011;2:1061-1068.
- Lin LT, Liu LT, Chiang LC, Lin CC. In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother Res. 2002;16(5):440-444. doi:10.1002/ptr.927
- Thring TS, Hili P, Naughton DP. Antioxidant and potential anti-inflammatory activity of extracts and formulations of white tea, rose, and witch hazel on primary human dermal fibroblast cells. J Inflamm (Lond). 2011;8:27. doi:10.1186/1476-9255-8-27
Carum Petroselinum (Parsley) Extract
1. Definition Carum Petroselinum (Parsley) Extract:
Carum Petroselinum (Parsley) Extract is a botanical extract derived from the leaves of the parsley plant. It is rich in vitamins, minerals, and antioxidants, making it a popular ingredient in skincare and haircare products.2. Use:
Carum Petroselinum (Parsley) Extract is known for its anti-inflammatory, antioxidant, and skin-brightening properties. It can help to reduce redness and inflammation, protect the skin from environmental damage, and promote a more even skin tone. In haircare products, parsley extract is believed to strengthen hair follicles, promote hair growth, and improve scalp health.3. Usage Carum Petroselinum (Parsley) Extract:
Carum Petroselinum (Parsley) Extract is commonly found in a variety of cosmetic products, including serums, creams, lotions, shampoos, and conditioners. It is typically used in small concentrations and can be applied directly to the skin or hair. It is important to patch test products containing parsley extract before use, especially for those with sensitive skin, to ensure there are no allergic reactions.4. References:
- Dweck, A. C. (2009). Parsley: A review of ethnopharmacology, phytochemistry and biological activities. Journal of Ethnopharmacology, 65(2), 133-142.
- Goyal, S., & Arora, D. (2010). Phyto-pharmacology of Carum petroselinum. International Journal of Pharmaceutical Sciences and Research, 1(9), 1-6.
- Kaur, G., & Kalia, A. N. (2016). Phytochemistry and pharmacological activities of Petroselinum crispum: A review. Journal of Pharmacognosy and Phytochemistry, 5(2), 207-212.
Cera Microcristallina (Microcrystalline Wax)
Ingredient data is being updated. Please check back later.
Lactic Acid
1. Definition Lactic Acid:
Lactic acid is a type of alpha hydroxy acid (AHA) that is naturally found in milk and various fruits. It is a gentle exfoliant that helps to remove dead skin cells, improve skin texture, and promote cell turnover.2. Use:
Lactic acid is commonly used in skincare products such as cleansers, toners, serums, and masks. It is known for its ability to hydrate the skin, improve skin tone and texture, reduce the appearance of fine lines and wrinkles, and brighten the complexion. Lactic acid is also effective in treating hyperpigmentation, acne, and sun damage.3. Usage Lactic Acid:
When using products containing lactic acid, it is important to start with a lower concentration and gradually increase the frequency of use to prevent irritation. It is recommended to use sunscreen daily when using lactic acid products, as they can increase skin sensitivity to the sun. Individuals with sensitive skin should patch test products containing lactic acid before applying them to the entire face.4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Baumann, L. (2009). Cosmetic dermatology: principles and practice. McGraw-Hill Medical.
- Arif, T. (2015). Salicylic acid as a peeling agent: a comprehensive review. Clinical, Cosmetic and Investigational Dermatology, 8, 455.
Magnesium Sulfate
1. Definition Magnesium Sulfate:
Magnesium Sulfate, also known as Epsom salt, is a mineral compound consisting of magnesium, sulfur, and oxygen. It is commonly used in cosmetics for its various benefits for the skin and hair.2. Use:
Magnesium Sulfate is often included in skincare products such as bath salts, body scrubs, and masks due to its exfoliating and detoxifying properties. It can help to remove dead skin cells, unclog pores, and improve overall skin texture. In hair care products, it is used to promote hair growth, strengthen hair follicles, and reduce scalp inflammation.3. Usage Magnesium Sulfate:
When using products containing Magnesium Sulfate, it is important to follow the instructions provided on the packaging. It is generally safe for most skin types, but individuals with sensitive skin may experience irritation. It is recommended to do a patch test before using the product on a larger area of the skin. Avoid contact with the eyes and rinse thoroughly if contact occurs. Overuse of products containing Magnesium Sulfate may lead to dryness or irritation, so it is best to use them in moderation.4. References:
- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2013). Safety assessment of magnesium sulfate as used in cosmetics. International journal of toxicology, 32(6_suppl), 5S-22S.
- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.
- Schreml, S., Szeimies, R. M., Prantl, L., Karrer, S., & Landthaler, M. (2008). A new concept of skin aging: In vivo aging of dermal collagen in skin. Experimental dermatology, 17(7), 549-557.
Manganese Sulfate
1. Definition Manganese Sulfate:
Manganese Sulfate is a chemical compound that is commonly used in cosmetics as a coloring agent. It is a pale pink to pale red crystalline powder that is water-soluble.2. Use:
Manganese Sulfate is primarily used in cosmetics to impart a pink or red color to various products such as lipsticks, eyeshadows, and blushes. It is also used in hair dyes and nail polishes to achieve desired shades.3. Usage Manganese Sulfate:
When using cosmetics containing Manganese Sulfate, it is important to follow the manufacturer's instructions and guidelines. It is recommended to perform a patch test before using the product on a larger area to check for any allergic reactions. Additionally, it is advisable to avoid ingesting or inhaling the product and to keep it out of reach of children.4. References:
- "Manganese Sulfate." CosmeticsInfo.org, www.cosmeticsinfo.org/ingredient/manganese-sulfate.
- "Manganese Sulfate in Cosmetics." Personal Care Council, www.personalcarecouncil.org/resource-center/manganese-sulfate-in-cosmetics/.
- "Safety Assessment of Manganese Compounds as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/manganese.pdf.
Paraffin
1. Definition Paraffin:
Paraffin is a type of mineral oil that is commonly used in cosmetics as an emollient to soften and smooth the skin. It is derived from petroleum and is a mixture of hydrocarbons.2. Use:
Paraffin is used in a variety of cosmetic products such as creams, lotions, lip balms, and hair care products. It helps to create a protective barrier on the skin, preventing moisture loss and keeping the skin hydrated. Paraffin also helps to improve the texture of the skin, making it feel soft and smooth.3. Usage Paraffin:
When using products containing paraffin, it is important to be aware of any potential allergies or sensitivities to the ingredient. Some people may experience irritation or breakouts when using products with paraffin, so it is recommended to do a patch test before applying it to a larger area of the skin. It is also important to follow the instructions on the product packaging and not to use excessive amounts of paraffin-containing products.4. References:
- "Paraffin in Cosmetics: What You Need to Know" by The Cosmetic Ingredient Review, https://www.cir-safety.org/ingredients/paraffin
- "The Benefits of Paraffin Wax for Skin" by Healthline, https://www.healthline.com/health/beauty-skin-care/paraffin-wax-benefits#benefits
- "The Truth About Paraffin Wax and Your Skin" by Dermascope, https://www.dermascope.com/scope-this/the-truth-about-paraffin-wax-and-your-skin
Paraffinum Liquidum (Mineral Oil)
1. Definition Mineral Oil:
Mineral oil is a colorless and odorless oil derived from petroleum. It is a common ingredient in skincare and cosmetic products due to its ability to lock in moisture and create a protective barrier on the skin.2. Use:
Mineral oil is used in cosmetics as an emollient to soften and smooth the skin. It is often found in moisturizers, lip balms, and makeup products to provide hydration and improve the overall texture of the skin.3. Usage Mineral Oil:
When using products containing mineral oil, it is important to note that it may clog pores for some individuals, leading to breakouts or irritation. It is recommended to perform a patch test before applying mineral oil-based products to the entire face or body to ensure compatibility with your skin.4. References:
- "Mineral Oil: The Good, the Bad, and the Ugly" by Paula Begoun
- "Mineral Oil in Skin Care: Good or Bad?" by Dr. Cynthia Bailey
- "The Truth About Mineral Oil" by Dr. Leslie Baumann
Parfum (Fragrance)
1. Definition Fragrance:
Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.
2. Use:
Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.
3. Usage Fragrance:
When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.
4. References:
- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.
- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.
- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.
Propylene Glycol
1. Definition Propylene Glycol:
Propylene Glycol is a synthetic liquid substance that absorbs water and is used in a variety of products, including cosmetics, as a humectant to help retain moisture.2. Use:
Propylene Glycol is commonly used in cosmetics as a solvent, emollient, and moisturizer. It helps to keep products stable and prevent them from drying out, while also providing a smooth texture and enhancing the absorption of other ingredients.3. Usage Propylene Glycol:
When using cosmetics containing Propylene Glycol, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to this ingredient, so it is recommended to perform a patch test before using a product with Propylene Glycol for the first time. Additionally, it is advisable to avoid using products with high concentrations of Propylene Glycol on broken or irritated skin.4. References:
- "Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel
- "Propylene Glycol" by the Environmental Working Group
- "Propylene Glycol in Cosmetics" by the Personal Care Products Council
Prunus Armeniaca (Apricot) Kernel Oil
1. Definition Prunus Armeniaca (Apricot) Kernel Oil:
Prunus Armeniaca (Apricot) Kernel Oil is a lightweight oil extracted from the kernels of apricots. It is rich in essential fatty acids, vitamins A and E, and antioxidants, making it a popular ingredient in skincare and haircare products.2. Use:
Apricot Kernel Oil is commonly used in cosmetics for its moisturizing and nourishing properties. It helps to hydrate and soften the skin, leaving it smooth and supple. The oil is also known for its ability to improve skin tone and texture, reduce inflammation, and promote skin elasticity. In haircare products, it can help to condition and strengthen the hair, leaving it shiny and manageable.3. Usage Prunus Armeniaca (Apricot) Kernel Oil:
Apricot Kernel Oil can be used in a variety of ways in cosmetics. It can be applied directly to the skin as a moisturizer or added to lotions, creams, serums, and balms to enhance their hydrating properties. In haircare products, it can be used in hair masks, conditioners, and styling products to improve the overall health and appearance of the hair.Precautions: While Apricot Kernel Oil is generally considered safe for most skin types, it is always recommended to perform a patch test before using it on larger areas of the skin. Some individuals may be allergic to apricots or other tree nuts, so it is important to check for any potential sensitivities. Additionally, it is best to store the oil in a cool, dark place away from direct sunlight to prevent oxidation and maintain its quality.
4. References:
- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. International Journal of Molecular Sciences, 19(1), 70.
- Ahmad, Z. (2010). The uses and properties of almond oil. Complementary Therapies in Clinical Practice, 16(1), 10-12.
- Ranzato, E., Martinotti, S., & Burlando, B. (2011). Wound healing properties of jojoba liquid wax: an in vitro study. Journal of Ethnopharmacology, 134(2), 443-449.
Reseda Luteola Extract
1. Definition Reseda Luteola Extract:
Reseda Luteola Extract, also known as weld or dyer's rocket, is a natural plant extract derived from the Reseda Luteola plant. It is commonly used in cosmetics for its skin conditioning and soothing properties.2. Use:
Reseda Luteola Extract is used in cosmetics for its anti-inflammatory, antioxidant, and anti-aging properties. It helps to soothe and calm irritated skin, reduce redness, and protect the skin from environmental damage. It is often found in skincare products such as serums, creams, and masks.3. Usage Reseda Luteola Extract:
Reseda Luteola Extract can be found in various skincare products, including creams, lotions, serums, and masks. It is typically used in small concentrations and should be applied to clean skin as part of a regular skincare routine. It is generally safe for most skin types, but it is always recommended to do a patch test before using any new product containing Reseda Luteola Extract to ensure compatibility with your skin.4. References:
- Kim, J. E., Park, S. J., Lee, J. H., Park, Y. H., & Park, S. D. (2015). Anti-inflammatory mechanism of Reseda luteola L. in lipopolysaccharide-stimulated RAW 264.7 macrophages. Journal of Ethnopharmacology, 168, 1-8.
- Wang, J., Zhang, Q., Zhang, Z., Li, Z., & Zhao, H. (2018). Antioxidant and anti-inflammatory activities of Reseda luteola L. extracts. Industrial Crops and Products, 120, 226-233.
- Pazyar, N., Yaghoobi, R., & Jamshydian, N. (2012). Herbal and plant therapy in patients with acne. Journal of the European Academy of Dermatology and Venereology, 26(1), 106-115.
Simmondsia Chinensis Seed Oil
1. Definition Simmondsia Chinensis (Jojoba) Seed Oil:
Simmondsia Chinensis (Jojoba) Seed Oil is a natural oil extracted from the seeds of the Jojoba plant. It is known for its moisturizing and nourishing properties, making it a popular ingredient in skincare and haircare products.2. Use:
Jojoba Seed Oil is commonly used in cosmetics for its ability to mimic the natural oils produced by the skin, making it suitable for all skin types. It is often found in moisturizers, serums, and hair treatments due to its hydrating and conditioning properties. Jojoba Seed Oil is also known for its anti-inflammatory and antibacterial properties, making it beneficial for soothing irritated skin and preventing breakouts.3. Usage Simmondsia Chinensis (Jojoba) Seed Oil:
Jojoba Seed Oil can be used directly on the skin or hair as a standalone product or mixed with other ingredients to create DIY skincare or haircare products. It can be applied to the face, body, or hair to moisturize, nourish, and protect the skin and hair follicles. When using Jojoba Seed Oil, it is important to perform a patch test first to ensure compatibility with your skin and to avoid any potential allergic reactions. It is also recommended to store Jojoba Seed Oil in a cool, dark place to maintain its quality and extend its shelf life.4. References:
- Paula Begoun, Bryan Barron, The Best Skin of Your Life Starts Here: Busting Beauty Myths So You Know What to Use and Why, 2015
- Ratan K. Choudhary, Avinash Kumar, Om Prakash, Mahendra Singh, Handbook of Medicinal Plants: Utilisation and Conservation, 2018
- Jennifer Peace Rhind, Fragrance and Wellbeing: Plant Aromatics and Their Influence on the Psyche, 2013
Sorbitan Caprylate
1. Definition Sorbitan Caprylate:
Sorbitan Caprylate is a natural emulsifier derived from sorbitol and caprylic acid. It is commonly used in cosmetics as a stabilizer and preservative.2. Use:
Sorbitan Caprylate is used in a variety of cosmetic products such as creams, lotions, and serums to help maintain the stability of the formulation. It also acts as a preservative, extending the shelf life of the product by inhibiting the growth of bacteria and fungi.3. Usage Sorbitan Caprylate:
When using products containing Sorbitan Caprylate, it is important to follow the manufacturer's instructions for application. It is generally considered safe for topical use, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient. It is recommended to avoid contact with eyes and mucous membranes.4. References:
- Cosmeticsinfo.org. (n.d.). Sorbitan Caprylate. Retrieved from https://cosmeticsinfo.org/ingredient/sorbitan-caprylate
- Personal Care Council. (2019). Sorbitan Caprylate. Retrieved from https://www.personalcarecouncil.org/ingredient-info/sorbitan-caprylate/
- U.S. Food and Drug Administration. (2021). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.845
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