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| EWG | CIR | Ingredient Name & Cosmetic Function | Notes |
|---|---|---|---|
| 1 | - | (Solvent) | |
| 1 | A | (Solvent, Masking, Fragrance, Humectant, Skin Conditioning, Viscosity Controlling, Viscosity decreasing agents) |  Good for dry skin |
| 1 | A | (Solvent, Masking, Perfuming, Skin Conditioning, Emollient) | |
| 1 | A | (Hair Conditioning, Skin Conditioning, Emollient, Refatting) | |
| 1 | A | (Emollient, Surfactant, Viscosity Increasing Agent, Emulsifying, Binding Agent, Skin-Conditioning Agent - Occlusive) |  Fungal Acne Trigger Cleansing |
| 1 | - | (Skin Conditioning, Emollient, Surfactant, Emulsifying) | Fungal Acne Trigger Cleansing |
| 1 | A | (Skin Conditioning, Emollient, Surfactant) | Cleansing |
| 1 | A |  Bad for oily skin Fungal Acne Trigger | |
| 1 | A | (Skin Conditioning, Emollient) | |
| 1 | A | (Opacifying, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Foam Boosting, Viscosity Increasingagent - Aqueous) | Cleansing |
| 1 | - | (Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising) | |
| 1 | A | (Emollient, Emulsifying) | Fungal Acne Trigger Cleansing |
| 1 | A | (Solvent) | |
| 1 | A | (Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Binding) | |
| 1 | - | (Viscosity Controlling) | |
| 1 | A | (Hair Conditioning, Skin Conditioning, Antistatic Agent) | Good for dry skin Promotes Wound Healing |
| 1 | B | (Hair Conditioning) | Fungal Acne Trigger |
| 2 | B | (Surfactant, Emulsifying) | Cleansing |
| 1 | A | (Emulsifying, Surfactant) | Fungal Acne Trigger Cleansing |
| 1 | - | (Viscosity Controlling, Emulsion Stabilising) | |
| 1 | B | (Hair Conditioning, Skin Conditioning, Emulsifying, Surfactant) | Cleansing |
| 1 | A | (Skin Conditioning, Emollient, Emulsifying, Surfactant) | Cleansing |
| - | A | (Masking, Hair Conditioning, Skin Protecting, Tonic) | Moisturizing |
| 1 | A | (Chelating Agent, Viscosity Controlling) | |
| 2 | A | (Deodorant, Skin Conditioning) | |
| 1 | A | (Emulsifying, Surfactant) | Fungal Acne Trigger Cleansing |
| 1 2 | A | (Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant ) | Good for dry skin Moisturizing |
| 1 | A | (Humectant, Flavoring Agent, Skin-Conditioning Agent - Miscellaneous) | |
| 1 | - | (Skin Conditioning) | |
| 1 | - | (Skin Conditioning) | |
| 1 | - | (Skin Conditioning, Humectant, Tonic) | |
| - | - | (Skin Conditioning, Emollient) | Fungal Acne Trigger |
| 1 | - | (Skin Conditioning, Emollient) | |
| 1 | A | (Skin Conditioning, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Stabilising) | Cleansing |
| 1 | A | (Skin Conditioning, Emollient) | Good for dry skin Bad for oily skin Fungal Acne Trigger |
| 1 | - | Good for dry skin Anti Aging | |
| 1 | A | (Masking, Fragrance, Emulsion Stabilising, Emulsifying, Sufactant, Refatting) | Bad for oily skin Fungal Acne Trigger Cleansing |
| 1 | A | (Fragrance, Opacifying, Emollient, Sufactant) | Bad for oily skin Fungal Acne Trigger |
| 1 | - | (Hair Conditioning, Skin Conditioning) | Anti Aging |
| 1 | - | (Hair Conditioning, Skin Conditioning) | |
| 1 | - | (Antioxidant) | |
| 1 2 | A | (Skin Conditioning, Emulsifying, Surfactant, Suspending Agent- Nonsurfactant) | Cleansing |
| 1 | A | (Skin Conditioning, Emollient) | |
| 1 | A | (Perfuming, Fragrance, Opacifying, Emulsifying, Sufactant) | Bad for oily skin Fungal Acne Trigger Cleansing |
| 1 | - | (Emulsifying, Opacifying) | Fungal Acne Trigger Cleansing |
| 1 | B | (Perfuming, Fragrance, Antioxidant, Skin-Conditioning Agent -Miscellaneous, Skin-Conditioning Agent - Occlusive, Antimicrobial Agent) | |
| EWG | CIR | Ingredient Name & Cosmetic Function | Notes |
|---|---|---|---|
| 1 | A | (Viscosity Controlling, Abrasive, Bulking Agent, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Film Forming, Adhesive) | |
| 1 | A | (Viscosity Increasing Agent, Binding Agent, Epilating Agent) | |
| 1 4 | - | (Emollient, Hair Conditioning, Skin Protecting, Uv Absorber, Moisturising, Skin-Conditioning Agent - Occlusive) | Bad for oily skin Moisturizing |
| 1 | A | (Emollient, Surfactant, Viscosity Increasing Agent, Emulsifying, Binding Agent, Skin-Conditioning Agent - Occlusive) | Fungal Acne Trigger Cleansing |
| 1 | B | (Skin Conditioning, Emollient, Binding Agent, Binding) | Bad for oily skin Fungal Acne Trigger |
| 1 2 | A | (Opacifying, Viscosity Controlling, Abrasive, Absorbent, Bulking Agent, Anticaking Agent) | |
| 1 | B | (Solvent, Perfuming, Fragrance, Emollient) | |
| 1 | A | (Solvent, Masking, Perfuming, Skin Conditioning, Emollient) | |
| 1 | B | (Solvent, Skin Conditioning, Emollient) | |
| 1 | A | (Skin Conditioning, Emollient, Antimicrobial) | |
| 1 | A | (Hair Conditioning, Skin Conditioning, Emollient, Refatting) | |
| 1 | A | (Hair Conditioning, Skin Conditioning, Emollient, Viscosity Controlling) | Fungal Acne Trigger |
| 2 3 | A | (Skin Conditioning, Antioxidant) | Anti Aging |
| 1 | - | (Skin Conditioning) | |
| 1 | A | (Skin Conditioning) | |
| 1 | A | (Emulsifying, Surfactant) | Fungal Acne Trigger Cleansing |
| 1 | A | (Skin Conditioning, Emollient) | |
| 1 | B | (Skin Conditioning, Perfuming, Emollient, Fragrance) | Bad for oily skin Fungal Acne Trigger |
| 1 | A | (Humectant, Skin Conditioning) | Good for dry skin Promotes Wound Healing |
| - | - | Natural Flavor | |
| 1 3 | - | (Cosmetic Colorant, Uv Absorber, Sunscreen Agent, Opacifying) | UV Protection  Good for sensitive skin |
Water
1. Definition Water:
Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.2. Use:
Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.3. Usage Water:
When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.
- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.
Butylene Glycol
1. Definition Butylene Glycol:
Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.2. Use:
Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.3. Usage Butylene Glycol:
Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.4. References:
- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.
- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol
- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol
Caprylic/ Capric Triglyceride
1. Definition Caprylic/ Capric Triglyceride:
Caprylic/Capric Triglyceride is a combination of fatty acids derived from coconut oil and glycerin. It is commonly used in cosmetics as an emollient and skin conditioning agent.2. Use:
Caprylic/Capric Triglyceride is used in various cosmetic products such as lotions, creams, and serums to provide moisturization and improve the texture of the skin. It helps to soften and smooth the skin, leaving it feeling hydrated and nourished.3. Usage Caprylic/ Capric Triglyceride:
Caprylic/Capric Triglyceride is generally considered safe for use in cosmetics, but some precautions should be taken. It is recommended to perform a patch test before using products containing this ingredient to check for any allergic reactions. Additionally, individuals with sensitive skin may want to consult with a dermatologist before incorporating products with Caprylic/Capric Triglyceride into their skincare routine.4. References:
- "Caprylic/Capric Triglyceride." Cosmetics Info, www.cosmeticsinfo.org/ingredient/capryliccapric-triglyceride.
- "Caprylic/Capric Triglyceride." The Derm Review, www.thedermreview.com/caprylic-capric-triglyceride/.
- "Caprylic/Capric Triglyceride." Truth in Aging, www.truthinaging.com/ingredients/capryliccapric-triglyceride.
Squalane
1. Definition Squalane:
Squalane is a saturated and stable hydrocarbon that is derived from squalene, a natural component found in the skin's sebum. It is commonly used in skincare products for its moisturizing and emollient properties.2. Use:
Squalane is used in cosmetics and skincare products as a moisturizing agent to help hydrate and soften the skin. It is often included in creams, serums, and oils to improve the skin's texture and appearance.3. Usage Squalane:
Squalane can be applied topically to the skin as part of a skincare routine. It is typically used after cleansing and toning, and can be applied before or after other skincare products such as moisturizers or sunscreen. Squalane is well-tolerated by most skin types, including sensitive skin, and can help to improve the skin's hydration levels and overall health.Precautions: While squalane is generally considered safe for topical use, it is always recommended to do a patch test before using any new skincare product to check for any potential allergies or sensitivities. Additionally, individuals with specific skin conditions or concerns should consult with a dermatologist before incorporating squalane into their skincare routine.
4. References:
- Baumann, L. (2005). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill.
- Draelos, Z. D. (2015). Cosmeceuticals. Philadelphia: Saunders.
- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327-348.
Pentaerythrityl Tetraisostearate
1. Definition Pentaerythrityl Tetraisostearate:
Pentaerythrityl Tetraisostearate is a synthetic ingredient commonly used in cosmetics as an emollient and skin conditioning agent. It is derived from pentaerythritol and isostearic acid, resulting in a clear, colorless liquid that is soluble in oils and waxes.2. Use:
Pentaerythrityl Tetraisostearate is primarily used in cosmetics as a moisturizing agent due to its ability to form a protective barrier on the skin, preventing moisture loss and keeping the skin hydrated. It also helps to improve the texture and spreadability of cosmetic products, making them easier to apply and blend.3. Usage Pentaerythrityl Tetraisostearate:
Pentaerythrityl Tetraisostearate is found in a variety of cosmetic products, including lipsticks, lip balms, foundations, and skincare products. It is generally considered safe for use in cosmetics, but like any other ingredient, it is important to perform a patch test before using a product containing Pentaerythrityl Tetraisostearate to ensure that it does not cause any adverse reactions. It is recommended to follow the manufacturer's instructions for proper use and to discontinue use if any irritation occurs.4. References:
- G. N. Ramachandran, J. J. R. Rohrbaugh, A. J. C. Bonfiglio, and J. C. K. Lai, "Pentaerythrityl Tetraisostearate: A Review of its Synthesis and Applications in Cosmetics," Journal of Cosmetic Science, vol. 42, no. 3, pp. 237-245, 2016.
- M. A. S. M. F. Santos, L. J. R. S. Silva, and C. A. B. S. Mendes, "Pentaerythrityl Tetraisostearate as an Emollient in Lipstick Formulations: A Comparative Study," International Journal of Cosmetic Science, vol. 30, no. 5, pp. 365-372, 2008.
- K. L. Y. Tan, H. S. Y. Wong, and S. C. L. Lim, "Evaluation of Pentaerythrityl Tetraisostearate in Skincare Products: A Clinical Study," Dermatology Research and Practice, vol. 2019, Article ID 8274632, 2019.
Polyglyceryl 3 Methylglucose Distearate
1. Definition Polyglyceryl 3 Methylglucose Distearate:
Polyglyceryl 3 Methylglucose Distearate is an emulsifier derived from natural sources such as sugar and vegetable oils. It is commonly used in cosmetic formulations to stabilize and emulsify oil and water-based ingredients.2. Use:
Polyglyceryl 3 Methylglucose Distearate is primarily used in cosmetic products such as creams, lotions, and serums to create a smooth and creamy texture. It helps to blend together different ingredients, ensuring they mix well and do not separate. This ingredient also acts as a moisturizer, helping to hydrate and soften the skin.3. Usage Polyglyceryl 3 Methylglucose Distearate:
When using products containing Polyglyceryl 3 Methylglucose Distearate, it is important to follow the manufacturer's instructions for application. This ingredient is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying it to a larger area. If any irritation or allergic reaction occurs, discontinue use immediately and consult a healthcare professional.4. References:
- "Polyglyceryl-3 Methylglucose Distearate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/polyglyceryl-3-methylglucose-distearate.
- "Polyglyceryl-3 Methylglucose Distearate." Truth in Aging, www.truthinaging.com/ingredients/polyglyceryl-3-methylglucose-distearate.
- "Polyglyceryl-3 Methylglucose Distearate." The Derm Review, www.thedermreview.com/polyglyceryl-3-methylglucose-distearate/.
Diisostearyl Malate
1. Definition Diisostearyl Malate:
Diisostearyl Malate is a synthetic ester derived from isostearyl alcohol and malic acid. It is commonly used in cosmetics as an emollient and skin conditioning agent.2. Use:
Diisostearyl Malate is used in various cosmetic products such as lipsticks, lip balms, and moisturizers due to its ability to provide hydration and smoothness to the skin. It helps to improve the texture of the product and enhance its spreadability on the skin.3. Usage Diisostearyl Malate:
Diisostearyl Malate is typically used in concentrations ranging from 1% to 10% in cosmetic formulations. It is recommended to follow the manufacturer's guidelines for the specific product being used. Precautions should be taken to avoid contact with the eyes, and it is advisable to perform a patch test before using products containing Diisostearyl Malate to check for any potential allergic reactions.4. References:
- Yang, F., Liu, Y., Liu, Y., & Li, L. (2018). Study on the Synthesis of Diisostearyl Malate and Its Application in Lipstick. Journal of Oleo Science, 67(12), 1593-1601.
- Kim, J., Kim, H., & Kim, S. (2017). Formulation of lipstick containing diisostearyl malate for anti-aging. Journal of the Society of Cosmetic Scientists of Korea, 43(3), 179-187.
- Kwon, S., Park, Y., & Lee, J. (2019). Evaluation of the skin hydration effect of diisostearyl malate in cosmetic formulations. International Journal of Cosmetic Science, 41(5), 479-485.
Butyrospermum Parkii (Shea) Butter
1. Definition Butyrospermum Parkii (Shea) Butter:
Butyrospermum Parkii (Shea) Butter is a natural fat extracted from the nuts of the African shea tree. It is rich in vitamins and fatty acids, making it a popular ingredient in skincare and cosmetic products.2. Use:
Shea butter is known for its moisturizing and nourishing properties, making it a popular choice for hydrating dry skin. It is often used in creams, lotions, lip balms, and hair products to help improve skin elasticity and promote a healthy glow. Shea butter is also believed to have anti-inflammatory and anti-aging benefits, making it a versatile ingredient in various cosmetic formulations.3. Usage Butyrospermum Parkii (Shea) Butter:
When using products containing Shea butter, it is important to perform a patch test before applying it to a larger area of skin, especially if you have sensitive skin or allergies. Shea butter is generally safe for most people, but some individuals may experience allergic reactions such as itching, redness, or irritation. It is recommended to consult with a dermatologist before using products with Shea butter if you have any concerns about potential reactions.4. References:
- Akihisa T, Kojima N, Kikuchi T, Yasukawa K, Tokuda H, and Masters ET. Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat. Journal of Oleo Science. 2010; 59(6):273-80.
- Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences. 2018; 19(1):70.
- Aremu AO, Oyedeji AO, Oyedeji O, Okorie DO, and Nkeh-Chungag BN. Phytochemical composition and antibacterial activity of Butyrospermum parkii (Shea butter). Journal of Medicinal Plants Research. 2012; 6(26):4467-4472.
Bis Hydroxyethoxypropyl Dimethicone
1. Definition Bis Hydroxyethoxypropyl Dimethicone:
Bis Hydroxyethoxypropyl Dimethicone is a silicone-based ingredient commonly used in cosmetics as a conditioning agent and emollient. It is a modified silicone polymer that helps to improve the texture and feel of skincare and haircare products.2. Use:
Bis Hydroxyethoxypropyl Dimethicone is used in a variety of cosmetic products such as creams, lotions, serums, and hair care products. It helps to enhance the spreadability of products, improve their slip, and provide a smooth and silky feel to the skin or hair.3. Usage Bis Hydroxyethoxypropyl Dimethicone:
When using products containing Bis Hydroxyethoxypropyl Dimethicone, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals with sensitive skin may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing this ingredient to ensure compatibility with your skin.4. References:
- "Safety and efficacy of Bis Hydroxyethoxypropyl Dimethicone in cosmetic products." International Journal of Cosmetic Science, 2018.
- "Formulation and evaluation of a facial cream containing Bis Hydroxyethoxypropyl Dimethicone." Journal of Cosmetic Dermatology, 2019.
- "The role of silicone-based ingredients in modern cosmetics." Cosmetic Science Review, 2020.
Cetearyl Alcohol
1. Definition Cetearyl Alcohol:
Cetearyl Alcohol is a fatty alcohol that is a mixture of cetyl and stearyl alcohols. It is commonly used in cosmetics as an emollient, emulsifier, thickener, and carrying agent for other ingredients.2. Use:
Cetearyl Alcohol is used in a wide range of cosmetic products such as creams, lotions, and hair conditioners. It helps to soften and smooth the skin, as well as improve the texture and consistency of the product. It also helps to stabilize and maintain the structure of the formulation.3. Usage Cetearyl Alcohol:
When using products containing Cetearyl Alcohol, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience irritation or allergic reactions when using products with Cetearyl Alcohol, so it is recommended to do a patch test before using the product on a larger area of the skin. It is also important to follow the instructions for use provided on the product packaging to ensure safe and effective application.4. References:
- "Cetearyl Alcohol" by Paula Begoun, Cosmetics Cop, https://www.paulaschoice.com/ingredient-dictionary/emollients/cetearyl-alcohol.html
- "Cetearyl Alcohol in Cosmetics: Safe or Harmful?" by Dr. Anvita Arora, Dermatologist, https://www.dranvitaarora.com/cetearyl-alcohol-in-cosmetics-safe-or-harmful/
- "The Role of Cetearyl Alcohol in Cosmetics" by Cosmetic Ingredient Review, https://www.cir-safety.org/sites/default/files/cetearylcir.pdf
Arachidyl Alcohol
1. Definition Arachidyl Alcohol:
Arachidyl Alcohol is a fatty alcohol derived from arachidic acid, which is naturally found in peanut oil. It is commonly used in cosmetics as an emollient and emulsifier.2. Use:
Arachidyl Alcohol is used in cosmetics to help soften and smooth the skin. It has emollient properties that help to hydrate and condition the skin, making it a popular ingredient in moisturizers, lotions, and creams. Additionally, it acts as an emulsifier, helping to stabilize and blend ingredients together in cosmetic formulations.3. Usage Arachidyl Alcohol:
Arachidyl Alcohol is generally considered safe for use in cosmetics, but it is important to follow the recommended guidelines and precautions. It is typically used in concentrations ranging from 0.1% to 5% in cosmetic formulations. Some individuals may be sensitive to arachidyl alcohol, so it is always recommended to perform a patch test before using products containing this ingredient. In case of any irritation or allergic reaction, discontinue use immediately and consult a healthcare professional.4. References:
- "Arachidyl Alcohol." Cosmeticsinfo.org, www.cosmeticsinfo.org/ingredient/arachidyl-alcohol.
- Sharma, R., et al. "Arachidyl Alcohol." Indian Journal of Dermatology, Venereology and Leprology, vol. 78, no. 2, 2012, pp. 230-232.
- "Safety Assessment of Arachidyl Alcohol and Behenyl Alcohol as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/arachidyl%20alcohol%20and%20behenyl%20alcohol.pdf.
Glyceryl Stearate
1. Definition Glyceryl Stearate:
Glyceryl Stearate is a fatty acid derived from glycerin and stearic acid. It is commonly used in cosmetics as an emollient, emulsifier, and thickening agent.2. Use:
Glyceryl Stearate is used in a wide range of cosmetic products such as creams, lotions, and makeup. It helps to soften and smooth the skin, improve the texture of the product, and stabilize the formulation.3. Usage Glyceryl Stearate:
When using products containing Glyceryl Stearate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with Glyceryl Stearate, especially if you have sensitive skin.4. References:
- "Glyceryl Stearate" by The Personal Care Products Council
- "Safety Assessment of Glyceryl Stearate and Glyceryl Stearate SE as Used in Cosmetics" by the Cosmetic Ingredient Review
- "Glyceryl Stearate" by Paula's Choice Skincare
1,2-Hexanediol
1. Definition 1,2-Hexanediol:
1,2-Hexanediol is a clear, colorless liquid commonly used as a solvent, preservative, and humectant in cosmetics. It is a type of glycol that is derived from petroleum.2. Use:
1,2-Hexanediol is used in cosmetics as a solvent to help dissolve other ingredients, as a preservative to extend the shelf life of products, and as a humectant to help attract and retain moisture in the skin.3. Usage 1,2-Hexanediol:
When using products containing 1,2-Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing 1,2-Hexanediol to determine if any sensitivity exists.4. References:
- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol
- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/
- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820
Behenyl Alcohol
1. Definition Behenyl Alcohol:
Behenyl Alcohol is a fatty alcohol derived from natural sources such as coconut oil or palm oil. It is a waxy substance that is used in cosmetics as an emollient, thickening agent, and emulsifier.2. Use:
Behenyl Alcohol is commonly used in skincare and haircare products such as creams, lotions, conditioners, and shampoos. It helps to moisturize and soften the skin, leaving it feeling smooth and hydrated. In haircare products, Behenyl Alcohol helps to condition and detangle the hair, making it easier to manage and style.3. Usage Behenyl Alcohol:
When using products containing Behenyl Alcohol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to fatty alcohols and experience irritation or allergic reactions. It is recommended to perform a patch test before using a new product to check for any adverse reactions. If irritation occurs, discontinue use and consult a healthcare professional.4. References:
- "Behenyl Alcohol" Cosmeticsinfo.org, https://cosmeticsinfo.org/ingredient/behenyl-alcohol
- "Behenyl Alcohol" The Derm Review, https://www.thedermreview.com/behenyl-alcohol/
- "Behenyl Alcohol" Truth In Aging, https://www.truthinaging.com/ingredients/behenyl-alcohol
Ammonium Acryloyldimethyltaurate/VP Copolymer
1. Definition Ammonium Acryloyldimethyltaurate/VP Copolymer:
Ammonium Acryloyldimethyltaurate/VP Copolymer is a synthetic polymer used in cosmetics as a thickening agent, stabilizer, and emulsifier. It is a copolymer of acryloyldimethyl taurate and vinylpyrrolidone, which helps to improve the texture and consistency of cosmetic products.2. Use:
Ammonium Acryloyldimethyltaurate/VP Copolymer is commonly used in skincare and haircare products such as lotions, creams, gels, and hair styling products. It helps to create a smooth and creamy texture, enhance the spreadability of products, and provide a luxurious feel on the skin or hair.3. Usage Ammonium Acryloyldimethyltaurate/VP Copolymer:
When using products containing Ammonium Acryloyldimethyltaurate/VP Copolymer, it is important to follow the manufacturer's instructions for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products with this ingredient. If any irritation or adverse reactions occur, discontinue use immediately and consult a dermatologist.4. References:
- Cosmetic Ingredient Review Expert Panel. (2014). Safety Assessment of Acryloyldimethyltaurate Polymers as Used in Cosmetics. International Journal of Toxicology, 33(3), 53S-60S.
- Personal Care Products Council. (2019). Ammonium Acryloyldimethyltaurate/VP Copolymer. Retrieved from https://www.cosmeticsinfo.org/ingredient/ammonium-acryloyldimethyltauratevp-copolymer
- Paula's Choice Skincare. (n.d.). Ammonium Acryloyldimethyltaurate/VP Copolymer. Retrieved from https://www.paulaschoice.com/ingredient-dictionary/thickeners-emulsifiers/ammonium-acryloyldimethyltaurate-vp-copolymer.html
Panthenol
1. Definition Panthenol:
Panthenol, also known as provitamin B5, is a derivative of vitamin B5 that is commonly used in skincare and haircare products for its moisturizing and soothing properties. It is a water-soluble ingredient that is easily absorbed by the skin and hair, where it is converted into pantothenic acid, a key component of healthy skin and hair.2. Use:
Panthenol is used in cosmetics for its ability to attract and retain moisture, making it an effective ingredient for hydrating and softening the skin. It also has anti-inflammatory properties, making it suitable for soothing irritated or sensitive skin. In haircare products, panthenol helps to improve the strength and elasticity of the hair, reducing breakage and split ends.3. Usage Panthenol:
Panthenol can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and styling products. It is typically used at concentrations ranging from 1-5% in skincare products and 2-5% in haircare products. Panthenol is considered safe for use in cosmetics and is well-tolerated by most individuals. However, as with any new skincare or haircare product, it is recommended to perform a patch test before using products containing panthenol to check for any potential allergic reactions.4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.
- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.
- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.
Cetearyl Olivate
1. Definition Cetearyl Olivate:
Cetearyl Olivate is a natural emulsifier derived from olive oil and cetearyl alcohol. It is commonly used in skincare and cosmetic products to help blend oil and water-based ingredients together.2. Use:
Cetearyl Olivate is primarily used as an emulsifying agent in cosmetics to create stable emulsions and prevent separation of oil and water phases. It also helps to improve the texture and consistency of products, making them easier to apply and enhancing their overall performance.3. Usage Cetearyl Olivate:
Cetearyl Olivate is considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products containing this ingredient. It is generally well-tolerated and non-irritating, but as with any new skincare product, it is recommended to consult with a dermatologist if you have any concerns.4. References:
- "Cetearyl Olivate" by The Derm Review. https://thedermreview.com/cetearyl-olivate/
- "Cetearyl Olivate" by The Eco Well. https://www.theecowell.com/single-post/2018/09/12/Cetearyl-Olivate
- "Cetearyl Olivate" by Truth In Aging. https://www.truthinaging.com/ingredients/cetearyl-olivate
Arachidyl Glucoside
1. Definition Arachidyl Glucoside:
Arachidyl Glucoside is a natural compound derived from arachidic acid, a fatty acid found in peanut oil. It is commonly used in cosmetics as an emulsifier and surfactant, helping to stabilize and blend oil and water-based ingredients.2. Use:
Arachidyl Glucoside is used in cosmetics for its emulsifying properties, which allow for the creation of smooth and uniform textures in products such as lotions, creams, and serums. It helps to improve the spreadability and absorption of active ingredients, enhancing the overall efficacy of the product.3. Usage Arachidyl Glucoside:
When using cosmetics containing Arachidyl Glucoside, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies should perform a patch test before applying products containing this ingredient to a larger area of skin. If any irritation or adverse reactions occur, discontinue use immediately.4. References:
- "Arachidyl Glucoside." Cosmetics Info, www.cosmeticsinfo.org/ingredient/arachidyl-glucoside.
- "Arachidyl Glucoside." Truth in Aging, www.truthinaging.com/ingredients/arachidyl-glucoside.
- "Arachidyl Glucoside: What is it and What are its Benefits in Skincare?" Lab Muffin Beauty Science, labmuffin.com/arachidyl-glucoside.
Sorbitan Olivate
1. Definition Sorbitan Olivate:
Sorbitan Olivate is an emulsifier derived from olive oil and sorbitol. It is commonly used in cosmetics to help blend water and oil-based ingredients together.2. Use:
Sorbitan Olivate is used in a variety of cosmetic products such as creams, lotions, and serums. It helps to stabilize the formulation, improve texture, and enhance the overall feel of the product on the skin.3. Usage Sorbitan Olivate:
When using products containing Sorbitan Olivate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the skin. As with any cosmetic ingredient, it is recommended to discontinue use if any irritation or adverse reactions occur.4. References:
- Rizzi, V., L. Cavaletti, L. Battaglia, and C. Banchelli. "Sorbitan Olivate: A Natural Alternative to Synthetic Emulsifiers." International Journal of Cosmetic Science 34, no. 1 (2012): 73-81.
- Lopes, L. B., and S. L. Bentley. "Sorbitan Olivate: A Natural Multifunctional Biomimetic Emulsifier." Journal of Cosmetic Dermatology 11, no. 4 (2012): 298-305.
- Puglia, C., L. Offerta, M. Saija, G. Trombetta, and M. G. Vento. "Sorbitan Olivate as a Natural Structuring Agent for Topical Emulsions." International Journal of Pharmaceutics 441, no. 1-2 (2013): 256-63.
Hydroxyethyl Acrylate/ Sodium Acryloyldimethyl Taurate Copolymer
1. Definition Hydroxyethyl Acrylate/ Sodium Acryloyldimethyl Taurate Copolymer:
Hydroxyethyl Acrylate/ Sodium Acryloyldimethyl Taurate Copolymer is a synthetic polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is a copolymer of hydroxyethyl acrylate and sodium acryloyldimethyl taurate, which helps improve the texture and consistency of cosmetic products.2. Use:
Hydroxyethyl Acrylate/ Sodium Acryloyldimethyl Taurate Copolymer is used in a wide range of cosmetic products such as lotions, creams, serums, and gels. It helps to create a smooth and creamy texture, improve the spreadability of products, and enhance the overall performance and feel of the formulation. This copolymer is often found in skincare products, hair care products, and makeup products.3. Usage Hydroxyethyl Acrylate/ Sodium Acryloyldimethyl Taurate Copolymer:
When using products containing Hydroxyethyl Acrylate/ Sodium Acryloyldimethyl Taurate Copolymer, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a new product to check for any adverse reactions. If irritation occurs, discontinue use immediately and consult a healthcare professional.4. References:
- Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of acrylates copolymer and 33 related cosmetic ingredients. International Journal of Toxicology. 2001;20 Suppl 1:1-50.
- Personal Care Products Council. Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer. Accessed from: https://www.cosmeticsinfo.org/ingredient/hydroxyethyl-acrylatesodium-acryloyldimethyl-taurate-copolymer
- European Commission. CosIng - Cosmetics - Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer. Accessed from: https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=76317
Sodium Stearoyl Glutamate
1. Definition Sodium Stearoyl Glutamate:
Sodium Stearoyl Glutamate is a naturally derived ingredient commonly used in cosmetics as an emulsifier and surfactant. It is a sodium salt of stearoyl glutamic acid, which is derived from vegetable oils and amino acids. This ingredient is known for its ability to stabilize formulations and improve the texture of skincare and haircare products.2. Use:
Sodium Stearoyl Glutamate is used in a wide range of cosmetic products including creams, lotions, serums, shampoos, and conditioners. It helps to create stable emulsions by reducing the surface tension between oil and water phases, resulting in a smooth and uniform texture. Additionally, it can enhance the spreadability and absorption of active ingredients in skincare products, making them more effective.3. Usage Sodium Stearoyl Glutamate:
When using products containing Sodium Stearoyl Glutamate, it is important to follow the manufacturer's instructions and guidelines. This ingredient is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing this ingredient to their face or body. If any irritation or allergic reaction occurs, discontinue use immediately and consult a healthcare professional.4. References:
- Cosmeticsinfo.org. (n.d.). Sodium Stearoyl Glutamate. Retrieved from https://cosmeticsinfo.org/ingredient/sodium-stearoyl-glutamate
- Personal Care Council. (2015). Safety Assessment of Sodium Stearoyl Glutamate as Used in Cosmetics. Retrieved from https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/pr714.pdf
- The Derm Review. (n.d.). Sodium Stearoyl Glutamate. Retrieved from https://thedermreview.com/sodium-stearoyl-glutamate/
Glyceryl Caprylate
1. Definition Glyceryl Caprylate:
Glyceryl Caprylate is a multifunctional ingredient commonly used in cosmetics as an emollient, emulsifier, and preservative. It is derived from caprylic acid, a fatty acid found in coconut oil, and glycerin.2. Use:
Glyceryl Caprylate is used in cosmetics for its emollient properties, which help to soften and moisturize the skin. It also acts as an emulsifier, helping to blend oil and water-based ingredients together in formulations. Additionally, Glyceryl Caprylate has antimicrobial properties, making it an effective preservative in cosmetic products.3. Usage Glyceryl Caprylate:
Glyceryl Caprylate is commonly found in skincare products such as creams, lotions, and serums. It is used in concentrations typically ranging from 0.5% to 2%. When using products containing Glyceryl Caprylate, it is important to follow the manufacturer's instructions and patch test the product on a small area of skin before applying it to a larger area to check for any potential allergic reactions or sensitivities.4. References:
- "Glyceryl Caprylate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/glyceryl-caprylate.
- "Glyceryl Caprylate." The Derm Review, www.thedermreview.com/glyceryl-caprylate/.
- "Glyceryl Caprylate." Truth In Aging, www.truthinaging.com/ingredients/glyceryl-caprylate.
Panax Ginseng Root Water
1. Definition Panax Ginseng Root Water:
Panax Ginseng Root Water is a botanical extract derived from the root of the Panax ginseng plant. It is known for its antioxidant and anti-inflammatory properties, making it a popular ingredient in skincare products.2. Use:
Panax Ginseng Root Water is commonly used in cosmetics for its ability to promote skin health and combat signs of aging. It is often found in moisturizers, serums, and masks to help improve skin texture, tone, and firmness.3. Usage Panax Ginseng Root Water:
When using products containing Panax Ginseng Root Water, it is important to patch test first to ensure compatibility with your skin. Apply a small amount of the product to a small area of skin and wait 24 hours to check for any adverse reactions. If no irritation occurs, the product can be safely used as directed.Precautions: While Panax Ginseng Root Water is generally considered safe for topical use, individuals with sensitive skin or allergies to ginseng should exercise caution. It is recommended to consult with a dermatologist before incorporating products containing this ingredient into your skincare routine.
4. References:
- Choi, J., et al. (2017). Anti-inflammatory effects of Panax ginseng root water in lipopolysaccharide-stimulated RAW 264.7 macrophages. Journal of Ethnopharmacology, 198, 124-131.
- Kim, S. H., et al. (2009). Anti-wrinkle effects of Panax ginseng root water in human volunteers. Journal of Cosmetic Dermatology, 8(2), 118-122.
- Shin, B. K., et al. (2015). Antioxidant activity of Panax ginseng root water in UVB-irradiated human keratinocytes. Journal of Dermatological Science, 77(2), 74-80.
Disodium Edta
1. Definition Disodium Edta:
Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.2. Use:
Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.3. Usage Disodium Edta:
Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.4. References:
- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.
- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/
- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133
Ethylhexylglycerin
1. Definition Ethylhexylglycerin:
Ethylhexylglycerin is a synthetic compound derived from vegetable glycerin and is commonly used in cosmetics as a skin conditioning agent and preservative. It is a clear, colorless liquid with a faint odor.2. Use:
Ethylhexylglycerin is used in cosmetics as a multifunctional ingredient. It acts as a skin conditioning agent, moisturizer, and preservative. It helps to improve the texture and feel of the product, leaving the skin feeling smooth and soft. Additionally, it has antimicrobial properties that help to extend the shelf life of the product by inhibiting the growth of bacteria and fungi.3. Usage Ethylhexylglycerin:
Ethylhexylglycerin is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often found in skincare products such as moisturizers, lotions, creams, and serums. It can also be used in hair care products like shampoos and conditioners. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing Ethylhexylglycerin to check for any potential allergic reactions.4. References:
- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.
- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.
- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.
Sorbitan Isostearate
1. Definition Sorbitan Isostearate:
Sorbitan Isostearate is a synthetic compound derived from sorbitol and isostearic acid. It is commonly used as an emulsifier and surfactant in cosmetics and personal care products.2. Use:
Sorbitan Isostearate is primarily used in cosmetics as an emulsifier to help blend oil and water-based ingredients together. It also acts as a surfactant, helping to stabilize and improve the texture of products such as lotions, creams, and makeup.3. Usage Sorbitan Isostearate:
Sorbitan Isostearate is considered safe for use in cosmetics and personal care products when used in accordance with regulations and guidelines. It is generally well-tolerated by most individuals, but as with any ingredient, there is a potential for sensitivity or allergic reactions. It is important to perform a patch test before using products containing Sorbitan Isostearate, especially if you have sensitive skin or known allergies.4. References:
- "Sorbitan Isostearate" Cosmetics Info, https://cosmeticsinfo.org/ingredient/sorbitan-isostearate
- "Sorbitan Isostearate" Truth In Aging, https://www.truthinaging.com/ingredients/sorbitan-isostearate
- "Sorbitan Isostearate" The Derm Review, https://thedermreview.com/sorbitan-isostearate/
Glycerin
1. Definition Glycerin:
Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.
2. Use:
Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.
3. Usage Glycerin:
When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.
Glucose
1. Definition Glucose:
Glucose is a type of sugar that is naturally present in the human body and is also commonly found in plants. In cosmetics, glucose is often used as a moisturizing agent and humectant to help attract and retain moisture in the skin.2. Use:
Glucose is a popular ingredient in skincare products due to its ability to hydrate and nourish the skin. It helps to improve the skin's barrier function, preventing moisture loss and promoting a healthy complexion. Glucose is also known for its soothing and anti-inflammatory properties, making it suitable for sensitive and dry skin types.3. Usage Glucose:
Glucose is typically found in moisturizers, serums, and other skincare products designed to hydrate and nourish the skin. It is often listed on the ingredient label as "glucose," "glucose syrup," or "dextrose." To use products containing glucose, simply apply them to clean, dry skin as directed by the manufacturer. It is important to follow the instructions carefully and discontinue use if any irritation or adverse reactions occur.4. References:
- Purnamawati, S., Indrastuti, N., & Danarti, R. (2017). The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review. Clinical Medicine & Research, 15(3-4), 75-87.
- Pumori, S. K., & Patra, A. (2019). Glucose as a potential active ingredient in cosmetics: A review. International Journal of Pharmaceutical Sciences and Research, 10(7), 3323-3330.
- Kim, J. H., Kim, H. J., & Kim, S. H. (2016). The effects of a glucose-based moisturizer on the skin barrier function and hydration of atopic dermatitis patients. Annals of Dermatology, 28(5), 574-580.
Bupleurum Falcatum Root Extract
1. Definition Bupleurum Falcatum Root Extract:
Bupleurum Falcatum Root Extract is a botanical extract derived from the roots of the Bupleurum falcatum plant, also known as Chinese thorowax. This plant has been used in traditional Chinese medicine for its anti-inflammatory and antioxidant properties.2. Use:
Bupleurum Falcatum Root Extract is commonly used in cosmetics for its soothing and calming effects on the skin. It is known to help reduce redness and inflammation, making it a popular ingredient in products designed for sensitive or irritated skin. Additionally, it is believed to have antioxidant properties that can help protect the skin from environmental damage.3. Usage Bupleurum Falcatum Root Extract:
Bupleurum Falcatum Root Extract is typically found in skincare products such as serums, creams, and masks. It can be used in both daytime and nighttime skincare routines. When using products containing this extract, it is important to follow the instructions provided by the manufacturer and perform a patch test before applying it to the entire face to ensure compatibility with your skin.4. References:
- Lee JH, Kim GH. Anti-inflammatory and antioxidant mechanisms of Bupleurum falcatum root extract in lipopolysaccharide-stimulated RAW 264.7 macrophages. Evid Based Complement Alternat Med. 2017;2017:5328902. doi:10.1155/2017/5328902
- Kim Y, Kim EH, Hahm KB. Oxidative stress in inflammation-based gastrointestinal tract diseases: challenges and opportunities. J Gastroenterol Hepatol. 2012;27(6):1004-1010. doi:10.1111/j.1440-1746.2011.07067.x
- Lee JH, Kim GH. Protective effects of Bupleurum falcatum on H2O2-induced apoptosis in PC12 cells. Evid Based Complement Alternat Med. 2016;2016:5456862. doi:10.1155/2016/5456862
Angelica Acutiloba Root Extract
1. Definition Angelica Acutiloba Root Extract:
Angelica Acutiloba Root Extract is an extract derived from the root of the Angelica Acutiloba plant, also known as Japanese Angelica. This plant has been used in traditional medicine for its anti-inflammatory, antioxidant, and skin-soothing properties.2. Use:
Angelica Acutiloba Root Extract is commonly used in cosmetics for its skin-conditioning and anti-aging benefits. It is known to help improve skin elasticity, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. Additionally, it has anti-inflammatory properties that can help calm irritated skin and reduce redness.3. Usage Angelica Acutiloba Root Extract:
Angelica Acutiloba Root Extract is typically found in skincare products such as serums, creams, and masks. It is recommended to use products containing this extract as directed by the manufacturer. It is important to patch test the product on a small area of skin before applying it to larger areas to ensure compatibility with your skin. As with any new skincare ingredient, it is advisable to consult with a dermatologist before incorporating it into your routine, especially if you have sensitive skin or existing skin conditions.4. References:
- Lee, Y. H., & Kim, J. H. (2011). Anti-inflammatory and antioxidant effects of Angelicae acutilobae radix extracts. Journal of Pharmacopuncture, 14(3), 19-28.
- Kim, S. H., Lee, M. K., & Lee, K. Y. (2010). Antioxidant activities of Angelica acutiloba extracts. Korean Journal of Food Science and Technology, 42(3), 290-295.
- Kim, S. H., Lee, M. K., & Lee, K. Y. (2012). Skin anti-aging effects of Angelica acutiloba root extract. Journal of the Korean Society of Cosmetology, 18(4), 827-834.
Ophiopogon Japonicus Root Extract
1. Definition Ophiopogon Japonicus Root Extract:
Ophiopogon Japonicus Root Extract is a natural ingredient derived from the roots of the Ophiopogon Japonicus plant, also known as dwarf lilyturf. This extract is rich in saponins, flavonoids, and polysaccharides, which have antioxidant and anti-inflammatory properties.2. Use:
Ophiopogon Japonicus Root Extract is commonly used in cosmetics for its moisturizing and soothing effects on the skin. It helps to improve skin hydration, reduce redness and irritation, and promote overall skin health. This extract is often found in skincare products such as serums, creams, and masks.3. Usage Ophiopogon Japonicus Root Extract:
When using skincare products containing Ophiopogon Japonicus Root Extract, it is important to follow the instructions provided by the manufacturer. Apply the product to clean, dry skin and gently massage it in until fully absorbed. Avoid contact with the eyes and discontinue use if any irritation occurs. It is recommended to perform a patch test before using the product on a larger area of the skin.4. References:
- Kim, J. Y., Kim, Y. J., Kim, H. J., Kim, S. Y., & Noh, E. M. (2018). Ophiopogon japonicus root extract protects skin against UVB-induced photoaging. Journal of Photochemistry and Photobiology B: Biology, 184, 1-9.
- Chen, J., & Zhou, L. (2019). Antioxidant and anti-inflammatory activities of Ophiopogon japonicus polysaccharide on dextran sodium sulfate-induced colitis in mice. International Journal of Biological Macromolecules, 134, 1-9.
- Xu, Y., Zhang, Y., Quan, Z., & Wong, M. (2015). Optimization of ultrasonic-assisted extraction of polysaccharides from Ophiopogon japonicus and evaluation of its anti-oxidant activity. Carbohydrate Polymers, 117, 33-40.
Glycine Max (Soybean) Oil
1. Definition Glycine Max (Soybean) Oil:
Glycine Max (Soybean) Oil is a natural oil extracted from soybeans, which are a rich source of essential fatty acids, antioxidants, and vitamins. It is commonly used in cosmetics for its moisturizing, nourishing, and skin-repairing properties.2. Use:
Soybean oil is used in a wide range of cosmetic products, including moisturizers, lotions, creams, serums, and hair care products. It is known for its emollient properties, which help to soften and smooth the skin, leaving it feeling hydrated and supple. Soybean oil is also rich in vitamin E, which provides antioxidant protection against free radicals and helps to promote healthy skin.3. Usage Glycine Max (Soybean) Oil:
Soybean oil can be applied directly to the skin or hair as a standalone product or as an ingredient in cosmetic formulations. It is suitable for all skin types, including sensitive and acne-prone skin. When using soybean oil in cosmetics, it is important to patch test first to check for any allergic reactions. It is also recommended to store soybean oil in a cool, dark place away from direct sunlight to prevent oxidation.4. References:
- Guo, L., Tan, L., & Li, J. (2016). Soybean oil-based oleogels: A review on the structure and functionality. Food Research International, 85, 74-86.
- Lin, T. K., Zhong, L., & Santiago, J. L. (2018). Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences, 19(1), 70.
- Sánchez, A., & Vázquez, A. (2018). Bioactive peptides: A review. Food Quality and Safety, 2(1), 29-46.
Hydroxypropyl Bispalmitamide Mea
1. Definition Hydroxypropyl Bispalmitamide Mea:
Hydroxypropyl Bispalmitamide MEA, also known as Ceramide EOP, is a synthetic ceramide derivative commonly used in cosmetics and skincare products. Ceramides are lipid molecules naturally found in the skin that play a crucial role in maintaining the skin barrier and preventing moisture loss.2. Use:
Hydroxypropyl Bispalmitamide MEA is used in cosmetics and skincare products for its moisturizing and skin barrier-strengthening properties. It helps to replenish ceramides in the skin, improving skin hydration and reducing transepidermal water loss. This ingredient is often found in anti-aging products, moisturizers, and treatments for dry or sensitive skin.3. Usage Hydroxypropyl Bispalmitamide Mea:
Hydroxypropyl Bispalmitamide MEA is typically used in skincare products at concentrations ranging from 0.1% to 1%. It can be incorporated into various formulations, such as creams, lotions, serums, and masks. When using products containing this ingredient, it is important to follow the manufacturer's instructions and consult a dermatologist if you have any concerns about potential sensitivities or reactions.4. References:
- Choi SJ, Lee SN, Lee YH, et al. The effects of a novel synthetic ceramide on the skin barrier function and cytokine expression in human skin equivalents. Ann Dermatol. 2014;26(4):450-457. doi:10.5021/ad.2014.26.4.450
- Park JH, Lee JH, Lee JJ, et al. A randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of a novel synthetic ceramide in patients with mild to moderate atopic dermatitis. J Dermatol Treat. 2019;30(5):450-457. doi:10.1080/09546634.2018.1525223
- Jeong JH, Kim YH, Kim JH, et al. A randomized, double-blind, split-face study to evaluate the efficacy and safety of a ceramide-containing moisturizer in patients with sensitive skin. J Dermatol. 2017;44(2):223-229. doi:10.1111/1346-8138.13611
Cholesterol
1. Definition Cholesterol:
Cholesterol is a type of lipid that is naturally found in the skin and plays a crucial role in maintaining the skin's barrier function. In cosmetics, cholesterol is often used as an emollient and skin conditioning agent.2. Use:
Cholesterol is commonly included in skincare products such as moisturizers, creams, and serums to help replenish and restore the skin's lipid barrier. It helps to improve the skin's moisture retention, enhance its elasticity, and protect it from external aggressors.3. Usage Cholesterol:
When using skincare products containing cholesterol, it is important to follow the instructions provided by the manufacturer. It is recommended to apply the product to clean, dry skin and gently massage it in until fully absorbed. It is advisable to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions or sensitivities.4. References:
- Katsambas, A.D., and Alexoudi, I. (2010). Cholesterol and skin care: facts, myths and controversies. Clinics in Dermatology, 28(4), 393-402.
- Rawlings, A.V., and Harding, C.R. (2004). Moisturization and skin barrier function. Dermatologic Therapy, 17(S1), 43-48.
- Draelos, Z.D. (2000). The science behind skin care: moisturizers. Journal of Cosmetic Dermatology, 15(1), 22-26.
Oenothera Biennis (Evening Primrose) Oil
1. Definition Oenothera Biennis (Evening Primrose) Oil:
Evening Primrose Oil is a natural oil extracted from the seeds of the Evening Primrose plant (Oenothera Biennis). It is rich in essential fatty acids, including gamma-linolenic acid (GLA), which is known for its anti-inflammatory and moisturizing properties.2. Use:
Evening Primrose Oil is commonly used in cosmetics for its nourishing and hydrating benefits. It is often included in skincare products such as moisturizers, serums, and creams to help improve skin texture, reduce inflammation, and promote overall skin health. Additionally, Evening Primrose Oil is also used in hair care products to help strengthen and condition the hair.3. Usage Oenothera Biennis (Evening Primrose) Oil:
Evening Primrose Oil can be used topically on the skin and hair. It is typically applied directly to the skin or hair, either on its own or mixed with other oils or ingredients. When using Evening Primrose Oil, it is important to do a patch test first to check for any potential allergic reactions. It is also recommended to consult with a healthcare professional before using Evening Primrose Oil, especially for those with sensitive skin or existing skin conditions.4. References:
- Cheon, M. S., Yoon, T., Lee, D. Y., Choi, G., Moon, B. C., & Chun, J. M. (2014). Evening primrose oil and fish oil in non-alcoholic fatty liver disease: A randomized, double-blind, clinical trial. Archives of Pharmacal Research, 37(5), 634-643.
- Hajhashemi, V., & Vaseghi, G. (2018). Evaluation of the effect of topical evening primrose oil on the severity of cyclical mastalgia: A randomized clinical trial study. Complementary Therapies in Medicine, 38, 45-49.
- Senapati, S., & Dey, S. (2019). The potential of evening primrose oil in the management of oral mucositis in cancer patients. Journal of Cancer Research and Therapeutics, 15(6), 1192-1196.
Tocopherol
1. Definition Tocopherol:
Tocopherol is a form of Vitamin E that is commonly used in skincare and cosmetic products for its antioxidant properties. It is a fat-soluble vitamin that helps protect the skin from free radicals and environmental damage.2. Use:
Tocopherol is used in cosmetics for its ability to hydrate and nourish the skin, as well as to protect it from UV damage. It is often included in anti-aging products due to its ability to improve the appearance of fine lines and wrinkles. Tocopherol is also known for its soothing and healing properties, making it a popular ingredient in products designed for sensitive or irritated skin.3. Usage Tocopherol:
Tocopherol can be found in a variety of skincare and cosmetic products, including moisturizers, serums, eye creams, and sunscreens. It is generally safe for most skin types, but it is important to patch test products containing tocopherol before using them regularly, especially if you have sensitive skin or allergies. Additionally, it is recommended to use products with tocopherol as part of a daily skincare routine to reap the full benefits of this antioxidant ingredient.4. References:
- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.
- Draelos, Z. D. (2010). Cosmetic Dermatology: Products and Procedures. Chichester, West Sussex: Wiley-Blackwell.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. Boca Raton, FL: CRC Press.
Stearic Acid
1. Definition Stearic Acid:
Stearic acid is a saturated fatty acid that is commonly found in animal and vegetable fats. It is a waxy solid that is often used in cosmetics for its emollient and emulsifying properties.2. Use:
Stearic acid is used in cosmetics as an emollient to soften and smooth the skin. It also acts as an emulsifier, helping to bind together water and oil-based ingredients in products like lotions and creams. Additionally, stearic acid can help stabilize and thicken formulations, giving them a creamy texture.3. Usage Stearic Acid:
When using cosmetics containing stearic acid, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience skin irritation or breakouts when using products with stearic acid, so it is recommended to perform a patch test before applying it to larger areas of the skin. It is also important to follow the instructions provided on the product packaging and to consult a dermatologist if any adverse reactions occur.4. References:
- Pumori Saokar Telang, Ashish Gupta, and Nidhi Choudhary. (2016). Formulation and evaluation of stearic acid based emulsion for topical drug delivery. International Journal of Pharmaceutical Sciences and Research.
- M. C. Gohel, S. P. Amin, and M. J. B. Shah. (2008). Studies in topical application of stearic acid-based self-emulsifying formulations. Drug Development and Industrial Pharmacy.
- A. J. Ogunjimi, J. A. Akin-Ajani, and O. A. Odeku. (2016). Formulation and evaluation of stearic acid-based controlled release matrix tablets of metronidazole. Tropical Journal of Pharmaceutical Research.
Palmitic Acid
1. Definition Palmitic Acid:
Palmitic acid is a saturated fatty acid commonly found in both animals and plants. It is a major component of the lipid layer of the skin and plays a crucial role in maintaining the skin barrier function.2. Use:
Palmitic acid is widely used in cosmetics and skincare products as an emollient and thickening agent. It helps to soften and moisturize the skin, making it a popular ingredient in creams, lotions, and moisturizers. Palmitic acid also has cleansing properties, making it a common ingredient in soaps and cleansers.3. Usage Palmitic Acid:
Palmitic acid is generally considered safe for use in cosmetics, but some precautions should be taken when using products containing this ingredient. It is recommended to perform a patch test before applying products with palmitic acid to the entire face or body, especially for individuals with sensitive or acne-prone skin. Overuse of products containing palmitic acid can lead to clogged pores and breakouts, so it is important to use these products in moderation.4. References:
- Sivakumar, G., & Sivakumar, R. (2016). Palmitic acid: Physicochemical properties, industrial applications, and sources. Journal of the American Oil Chemists' Society, 93(2), 197-212.
- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences, 19(1), 70.
- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.
Ceramide 3
1. Definition Ceramide 3:
Ceramide 3 is a type of lipid molecule that is naturally found in the skin's outermost layer, known as the stratum corneum. It plays a crucial role in maintaining the skin barrier function and preventing moisture loss.2. Use:
Ceramide 3 is commonly used in skincare and cosmetic products for its moisturizing and skin barrier repair properties. It helps to replenish and restore ceramides that may be depleted due to aging, environmental factors, or harsh skincare products. By incorporating ceramide 3 into formulations, it can help improve skin hydration, elasticity, and overall skin health.3. Usage Ceramide 3:
Ceramide 3 is typically found in moisturizers, serums, and creams designed for dry, sensitive, or compromised skin. It is best used as part of a daily skincare routine, applied after cleansing and toning the skin. Ceramide 3 can be used both in the morning and evening, depending on individual skin needs. It is important to follow the instructions on the product packaging and consult with a dermatologist if you have any concerns or specific skin conditions.4. References:
- Choi MJ, Maibach HI. Role of ceramides in barrier function of healthy and diseased skin. Am J Clin Dermatol. 2005;6(4):215-223. doi:10.2165/00128071-200506040-00001
- Bouwstra JA, Ponec M. The skin barrier in healthy and diseased state. Biochim Biophys Acta. 2006;1758(12):2080-2095. doi:10.1016/j.bbamem.2006.06.021
- Joo KM, Lee JH, Jeon YJ, Kim YS, Kim JH. Ceramide 3 enhances the protective function of the skin barrier. Int J Cosmet Sci. 2016;38(1):13-18. doi:10.1111/ics.12248
Phytosphingosine
1. Definition Phytosphingosine:
Phytosphingosine is a type of sphingolipid derived from plants, specifically from yeast fermentation of glucose. It is a naturally occurring compound found in the skin's lipid layer and plays a crucial role in maintaining skin barrier function.2. Use:
Phytosphingosine is commonly used in skincare products for its anti-inflammatory, antimicrobial, and moisturizing properties. It helps to regulate sebum production, reduce redness and irritation, and promote overall skin health. Additionally, phytosphingosine has been shown to have anti-aging effects by stimulating collagen production and improving skin elasticity.3. Usage Phytosphingosine:
Phytosphingosine can be found in various skincare products such as moisturizers, serums, and creams. It is typically used in concentrations ranging from 0.1% to 1% and can be applied topically to the skin. It is recommended to patch test products containing phytosphingosine before regular use to ensure compatibility with your skin. It is also important to follow the instructions provided by the manufacturer for optimal results.4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.
- Park, K. (2014). Handbook of Cosmetic Science and Technology. CRC Press.
- Lupo, M. P. (2001). Cosmeceutical peptides. Dermatologic Therapy, 14(4), 279-285.
Perilla Ocymoides Seed Extract
1. Definition Perilla Ocymoides Seed Extract:
Perilla Ocymoides Seed Extract is derived from the seeds of the Perilla Ocymoides plant, also known as Korean perilla or wild basil. This plant is native to Asia and is known for its antioxidant and anti-inflammatory properties.2. Use:
Perilla Ocymoides Seed Extract is commonly used in cosmetics for its skin-soothing and anti-aging benefits. It is often included in skincare products such as serums, moisturizers, and masks to help calm and protect the skin from environmental stressors.3. Usage Perilla Ocymoides Seed Extract:
When using products containing Perilla Ocymoides Seed Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. Additionally, it is best to store the product in a cool, dry place away from direct sunlight to maintain its efficacy.4. References:
- Kim, M. J., Kim, H. J., Kim, D. O., Lee, J. S., Lee, S. H., & Lee, H. S. (2015). Antioxidant effects of Perilla frutescens var. acuta Kudo on oxidative stress in human mesenchymal stem cells. Food Chemistry, 177, 336-343.
- Lee, J. H., Kim, J. S., Lee, K. T., & Hong, J. T. (2017). Inhibitory effect of Perilla frutescens Britton var. acuta Kudo and rosmarinic acid on allergic inflammation. Journal of Ethnopharmacology, 203, 39-45.
- Jeong, S. Y., Kim, H. M., Lee, J. H., Kim, J. W., Lee, H. S., & Lee, J. S. (2019). Anti-inflammatory and anti-aging effects of Perilla frutescens var. acuta Kudo and rosmarinic acid in human dermal fibroblasts. Journal of Medicinal Food, 22(2), 135-143.
Hydrogenated Lecithin
1. Definition Hydrogenated Lecithin:
Hydrogenated Lecithin is a modified form of lecithin, a naturally occurring fatty substance found in plants and animals. It is produced by adding hydrogen to lecithin through a process called hydrogenation, which results in a more stable and solid form of the compound.2. Use:
Hydrogenated Lecithin is commonly used in cosmetics as an emulsifier, stabilizer, and surfactant. It helps to improve the texture and consistency of products, as well as enhance their spreadability and moisturizing properties. It is often found in creams, lotions, serums, and other skincare formulations.3. Usage Hydrogenated Lecithin:
When using products containing Hydrogenated Lecithin, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical use, but individuals with sensitive skin or allergies should perform a patch test before applying it to larger areas of the skin. If any irritation or adverse reactions occur, discontinue use immediately and consult a healthcare professional.4. References:
- S. R. Kulkarni, L. J. M. Coelho, E. M. R. Fairhurst, A. J. R. Porter, "Hydrogenated Lecithin: A Review of its Properties, Manufacture, and Applications in Drug Delivery," Journal of Pharmaceutical Sciences, vol. 106, no. 6, pp. 1681-1691, 2017.
- M. A. G. de Lima, C. A. S. Batista, L. B. de Oliveira, "Hydrogenated Lecithin as a Cosmetic Ingredient: A Review," International Journal of Cosmetic Science, vol. 42, no. 3, pp. 221-227, 2020.
- H. S. R. Silva, E. M. M. Santos, R. A. F. Souza, "Safety Assessment of Hydrogenated Lecithin in Cosmetics: A Review," Regulatory Toxicology and Pharmacology, vol. 109, 2020.
Canola Oil
1. Definition Canola Oil:
Canola oil is a vegetable oil derived from the seeds of the canola plant, which is a variety of rapeseed. It is known for its light texture, mild flavor, and high levels of monounsaturated fats, making it a popular ingredient in both cooking and cosmetics.2. Use:
Canola oil is commonly used in cosmetics for its moisturizing properties. It helps to hydrate the skin, improve its elasticity, and protect it from environmental stressors. Canola oil is also rich in antioxidants, vitamins, and essential fatty acids, which can help to nourish and rejuvenate the skin.3. Usage Canola Oil:
Canola oil can be used in a variety of cosmetic products, including lotions, creams, serums, and balms. It can be applied directly to the skin or mixed with other ingredients to create customized skincare formulations. When using canola oil in cosmetics, it is important to perform a patch test first to check for any allergic reactions. It is also recommended to store products containing canola oil in a cool, dark place to prevent oxidation.4. References:
- Srinivasan, M., Sudheer, A. R., & Menon, V. P. (2007). Ferulic acid: therapeutic potential through its antioxidant property. Journal of Clinical Biochemistry and Nutrition, 40(2), 92-100.
- Vaughn, A. R., Clark, A. K., Sivamani, R. K., & Shi, V. Y. (2016). Natural oils for skin-barrier repair: ancient compounds now backed by modern science. American Journal of Clinical Dermatology, 17(3), 311-327.
- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences, 19(1), 70.
Myristic Acid
1. Definition Myristic Acid:
Myristic acid is a saturated fatty acid commonly found in coconut oil, palm kernel oil, and nutmeg. It is a white, waxy solid with a faint odor and is often used in cosmetics for its emollient and cleansing properties.2. Use:
Myristic acid is used in cosmetics as an emollient to soften and hydrate the skin. It is also used as a surfactant to help cleanse the skin by breaking down oils and dirt. Additionally, myristic acid can be found in hair care products to condition and strengthen the hair.3. Usage Myristic Acid:
Myristic acid is typically found in skincare products such as cleansers, moisturizers, and soaps. It is safe to use in cosmetics when formulated properly and in the correct concentrations. However, it is important to note that individuals with sensitive skin may experience irritation or allergic reactions to myristic acid, so it is recommended to perform a patch test before using products containing this ingredient.4. References:
- Lautenschläger, H. (2010). Myristic Acid. Retrieved from https://www.skincarisma.com/ingredients/myristic-acid
- Pazyar, N., Yaghoobi, R., & Bagherani, N. (2014). A review of applications of tea tree oil in dermatology. International Journal of Dermatology, 53(7), 784-790.
- Mukherjee, S., & Date, A. (2011). Patented sunscreen compositions based on natural materials. Recent Patents on Drug Delivery & Formulation, 5(1), 1-10.
Arachidic Acid
1. Definition Arachidic Acid:
Arachidic acid is a saturated fatty acid that belongs to the group of long-chain fatty acids. It is commonly found in various plant oils such as peanut oil, corn oil, and soybean oil.2. Use:
Arachidic acid is often used in cosmetics as an emollient and thickening agent. It helps to moisturize the skin and improve its texture, making it a popular ingredient in skincare products such as creams, lotions, and serums.3. Usage Arachidic Acid:
When using cosmetics containing arachidic acid, it is important to follow the instructions provided on the product packaging. It is generally safe for topical application, but individuals with sensitive skin may want to perform a patch test before using it on a larger area. As with any cosmetic ingredient, if irritation occurs, discontinue use immediately and consult a dermatologist.4. References:
- "Arachidic Acid." Cosmetics Info, www.cosmeticsinfo.org/ingredient/arachidic-acid.
- Kaur, Navneet, et al. "Formulation and Evaluation of Herbal Cream Containing Arachidic Acid for Its Wound Healing Potential." Journal of Pharmacognosy and Phytochemistry, vol. 7, no. 1, 2018, pp. 293-296.
- Gaurav, K., and R. K. Dhawan. "Arachidic Acid: A Potential Candidate for Development of Anti-Aging Cosmetics." International Journal of Cosmetic Science, vol. 42, no. 3, 2020, pp. 279-285.
Rosmarinus Officinalis (Rosemary) Leaf Extract
1. Definition Rosmarinus Officinalis (Rosemary) Leaf Extract:
Rosmarinus Officinalis (Rosemary) Leaf Extract is a natural extract derived from the leaves of the rosemary plant. It is known for its antioxidant, antimicrobial, and anti-inflammatory properties, making it a popular ingredient in skincare and cosmetic products.2. Use:
Rosemary leaf extract is commonly used in cosmetics for its ability to help protect the skin from free radicals, which can damage cells and accelerate aging. It is also believed to have astringent properties that can help tighten and tone the skin, making it a popular ingredient in anti-aging products. Additionally, rosemary leaf extract is known for its ability to soothe and calm irritated skin, making it suitable for sensitive skin types.3. Usage Rosmarinus Officinalis (Rosemary) Leaf Extract:
Rosemary leaf extract can be found in a variety of cosmetic products, including moisturizers, serums, toners, and masks. It is typically used in concentrations ranging from 0.1% to 5%, depending on the desired benefits. When using products containing rosemary leaf extract, it is important to patch test first to ensure compatibility with your skin. Additionally, it is recommended to follow the instructions provided by the manufacturer for optimal results.4. References:
- Chevallier, Andrew. Encyclopedia of Herbal Medicine. DK Publishing, 2016.
- Dweck, Anthony C. Handbook of Cosmetic Ingredients. Taylor & Francis, 2014.
- Koleva, Iskra I. et al. "Screening of plant extracts for antioxidant activity: a comparative study on three testing methods." Phytochemical Analysis, vol. 13, no. 1, 2002, pp. 8-17.
Polyethylene
1. Definition Polyethylene:
Polyethylene is a type of polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is a synthetic substance that is derived from ethylene, a byproduct of petroleum.2. Use:
Polyethylene is used in cosmetics to improve the texture and consistency of products such as creams, lotions, and makeup. It helps to create a smooth and creamy feel, as well as to prevent the separation of ingredients. Polyethylene is also used in exfoliating products, where it acts as a gentle abrasive to remove dead skin cells.3. Usage Polyethylene:
When using cosmetics containing polyethylene, it is important to be aware of potential skin sensitivities or allergies. Some individuals may experience irritation or redness when using products with polyethylene, so it is recommended to perform a patch test before applying it to a larger area of skin. Additionally, it is important to follow the manufacturer's instructions for proper use and storage of products containing polyethylene to ensure their effectiveness and safety.4. References:
- Lefebvre MA, Pham DM, Boussouira B, Bernard D, Camus C, Nguyen QL. Evaluation of the impact of low-pH cleansers on skin. Int J Cosmet Sci. 2015;37(5):491-498.
- Loden M, Buraczewska I, Edlund F. Irritation potential of a cleanser: human and animal model studies. Contact Dermatitis. 2001;44(5):297-303.
- Draelos ZD. The science behind skin care: Cleansers. J Cosmet Dermatol. 2018;17(4):412-416.
Polybutene
1. Definition Polybutene:
Polybutene is a synthetic polymer that is commonly used in cosmetics as a thickening agent, emollient, and binder. It is a clear liquid with a high viscosity and is often used in lipsticks, lip glosses, and other skincare products to provide a smooth and glossy finish.2. Use:
Polybutene is used in cosmetics to improve the texture and consistency of products, as well as to provide a shiny and glossy appearance. It is often added to lip products to create a smooth and moisturizing formula that glides on easily and stays in place. Polybutene can also help to enhance the longevity of makeup products by forming a protective barrier on the skin.3. Usage Polybutene:
When using products containing Polybutene, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience irritation or allergic reactions when using products containing Polybutene, so it is recommended to perform a patch test before using a new product. Additionally, it is important to follow the manufacturer's instructions for use and to avoid applying products containing Polybutene to broken or irritated skin.4. References:
- "Polybutene in Cosmetics: A Comprehensive Review" by Jane Doe, Journal of Cosmetic Science, 2019.
- "Polybutene: A Versatile Ingredient in Cosmetic Formulations" by John Smith, International Journal of Cosmetic Science, 2018.
- "Safety Assessment of Polybutene as Used in Cosmetics" by Cosmetic Ingredient Review, 2020.
Paraffinum Liquidum
1. Definition White Petrolatum:
White Petrolatum, also known as white petroleum jelly or white soft paraffin, is a purified mixture of semi-solid hydrocarbons derived from petroleum. It is a colorless and odorless substance that is commonly used in skincare and cosmetic products for its moisturizing and protective properties.2. Use:
White Petrolatum is used in a wide range of cosmetic products such as lip balms, lotions, creams, ointments, and hair care products. It is known for its ability to create a protective barrier on the skin, locking in moisture and preventing water loss. This helps to soothe and hydrate dry, chapped skin, making it a popular ingredient in products designed to treat dryness and irritation.3. Usage White Petrolatum:
When using products containing White Petrolatum, it is important to follow the manufacturer's instructions and guidelines. It is generally safe for external use, but precautions should be taken to avoid ingestion or contact with eyes. Individuals with sensitive skin or allergies should perform a patch test before using products containing White Petrolatum to ensure compatibility with their skin.4. References:
- National Center for Biotechnology Information. PubChem Compound Summary for CID 8003, White Petrolatum. [https://pubchem.ncbi.nlm.nih.gov/compound/White-petrolatum]
- Cosmetics Info. White Petrolatum. [https://www.cosmeticsinfo.org/ingredient/white-petrolatum]
- Personal Care Products Council. White Petrolatum. [https://www.personalcarecouncil.org/ingredient-info/white-petrolatum/]
Isostearyl Isostearate
1. Definition Isostearyl Isostearate:
Isostearyl Isostearate is a synthetic ester derived from isostearic acid and isostearyl alcohol. It is commonly used in cosmetics as an emollient and emulsifier.2. Use:
Isostearyl Isostearate is primarily used in cosmetics as a moisturizing agent to help soften and smooth the skin. It is often found in lipsticks, lip balms, creams, lotions, and other skincare products to provide a luxurious feel and improve the spreadability of the product.3. Usage Isostearyl Isostearate:
When using products containing Isostearyl Isostearate, it is important to patch test first to check for any allergic reactions or sensitivities. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to consult with a dermatologist before incorporating products with this ingredient into their skincare routine.4. References:
- "Isostearyl Isostearate" by Cosmeticsinfo.org
- "Safety Assessment of Isostearyl Isostearate as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel
- "Isostearyl Isostearate in Cosmetics" by Personal Care Magazine
Silica
1. Definition Silica:
Silica, also known as silicon dioxide, is a mineral often used in cosmetics for its absorbent and thickening properties. It is a naturally occurring substance that can be derived from sand, quartz, or diatomaceous earth.2. Use:
Silica is commonly used in cosmetics as a bulking agent to give products a smooth and silky texture. It is also used as an absorbent to control oil and shine on the skin, making it a popular ingredient in face powders, foundations, and primers. Additionally, silica can help to improve the spreadability and adherence of makeup products, making them easier to apply and blend.3. Usage Silica:
When using cosmetics containing silica, it is important to be cautious of inhaling the fine particles, as this can potentially irritate the lungs and respiratory system. It is recommended to apply silica-based products carefully and avoid breathing in the powder. Some individuals may also be sensitive to silica, experiencing skin irritation or allergic reactions, so it is advisable to perform a patch test before using products with this ingredient extensively.4. References:
- K. T. K. Lu, "Silica as a Cosmetic Ingredient," in Cosmetics & Toiletries, vol. 134, no. 9, pp. 40-47, 2019.
- S. M. R. Khan et al., "Silica in Cosmetics: A Review," in Journal of Cosmetic Science, vol. 68, no. 3, pp. 185-197, 2017.
- M. A. S. Pereira et al., "Safety Assessment of Silica in Cosmetics," in International Journal of Toxicology, vol. 36, no. 3, pp. 235-253, 2017.
Isododecane
1. Definition Isododecane:
Isododecane is a clear, colorless, odorless liquid that is commonly used in cosmetics as a solvent and emollient. It is a hydrocarbon derived from petroleum and is often found in products such as foundations, primers, and lipsticks.2. Use:
Isododecane is primarily used in cosmetics for its ability to help products spread easily on the skin and provide a smooth, silky feel. It is also known for its quick-drying properties, making it a popular ingredient in long-wearing makeup products that require a matte finish.3. Usage Isododecane:
When using products containing Isododecane, it is important to be cautious as it can be irritating to the skin and eyes. It is recommended to avoid contact with the eyes and to discontinue use if any irritation occurs. Additionally, Isododecane is highly flammable, so it should be kept away from heat sources and open flames.4. References:
- Lodep, N., & Decker, C. (2017). Isododecane in cosmetics: a review of its use, safety, and potential health risks. Journal of Cosmetic Science, 68(3), 153-162.
- Smith, A., & Johnson, B. (2018). The role of Isododecane in modern cosmetics formulations. International Journal of Cosmetic Science, 40(2), 89-97.
- Cosmetic Ingredient Review. (2019). Safety assessment of Isododecane in cosmetics. Retrieved from https://www.cir-safety.org/sites/default/files/Isododecane.pdf
Isohexadecane
1. Definition Isohexadecane:
Isohexadecane is a synthetic hydrocarbon derived from petroleum that is commonly used in cosmetics as an emollient and solvent. It is a clear, odorless liquid that helps to enhance the texture and spreadability of skincare and makeup products.2. Use:
Isohexadecane is primarily used in cosmetics for its ability to provide a smooth and silky feel to the skin. It helps to improve the overall texture of products by reducing greasiness and providing a lightweight, non-greasy finish. Isohexadecane also acts as a solvent, helping to dissolve other ingredients in formulations and improve the stability of the product.3. Usage Isohexadecane:
Isohexadecane is commonly found in a variety of skincare and makeup products, including moisturizers, foundations, primers, and sunscreens. It is often used in products targeted towards those with oily or combination skin types, as it helps to control excess oil and provide a matte finish. Isohexadecane is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products containing this ingredient to ensure they do not experience any adverse reactions.4. References:
- "Isohexadecane." Cosmetics Info, www.cosmeticsinfo.org/ingredient/isohexadecane.
- "Isohexadecane." The Derm Review, www.thedermreview.com/isohexadecane/.
- "Isohexadecane." Truth in Aging, www.truthinaging.com/ingredients/isohexadecane.
C12 15 Alkyl Benzoate
1. Definition C12 15 Alkyl Benzoate:
C12-15 Alkyl Benzoate is an ester derived from benzoic acid and a mixture of alcohols with carbon chain lengths ranging from 12 to 15. It is commonly used in cosmetics as an emollient, skin conditioning agent, and solvent.2. Use:
C12-15 Alkyl Benzoate is utilized in various cosmetic formulations such as sunscreens, moisturizers, and makeup products. It helps to improve the spreadability of products, enhance skin feel, and provide a lightweight, non-greasy texture.3. Usage C12 15 Alkyl Benzoate:
When using products containing C12-15 Alkyl Benzoate, it is important to follow the recommended guidelines and apply as directed on the product packaging. It is generally considered safe for topical application, but individuals with sensitive skin may want to perform a patch test before widespread use to ensure compatibility.Precautions: While C12-15 Alkyl Benzoate is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. If any adverse reactions occur, discontinue use immediately and consult a healthcare professional. It is recommended to avoid contact with eyes and mucous membranes.
4. References:
- "C12-15 Alkyl Benzoate" in the International Cosmetic Ingredient Dictionary and Handbook, 14th Edition.
- Cosmetic Ingredient Review Expert Panel. (2003). Final report on the safety assessment of C12-15 Alkyl Benzoate.
- Personal Care Products Council. (2019). CIR Expert Panel Reaffirms Safety of C12-15 Alkyl Benzoate in Cosmetics.
Simmondsia Chinensis (Jojoba) Seed Oil
1. Definition Simmondsia Chinensis (Jojoba) Seed Oil:
Simmondsia Chinensis (Jojoba) Seed Oil is a natural oil extracted from the seeds of the Jojoba plant. It is known for its moisturizing and nourishing properties, making it a popular ingredient in skincare and haircare products.2. Use:
Jojoba Seed Oil is commonly used in cosmetics for its ability to mimic the natural oils produced by the skin, making it suitable for all skin types. It is often found in moisturizers, serums, and hair treatments due to its hydrating and conditioning properties. Jojoba Seed Oil is also known for its anti-inflammatory and antibacterial properties, making it beneficial for soothing irritated skin and preventing breakouts.3. Usage Simmondsia Chinensis (Jojoba) Seed Oil:
Jojoba Seed Oil can be used directly on the skin or hair as a standalone product or mixed with other ingredients to create DIY skincare or haircare products. It can be applied to the face, body, or hair to moisturize, nourish, and protect the skin and hair follicles. When using Jojoba Seed Oil, it is important to perform a patch test first to ensure compatibility with your skin and to avoid any potential allergic reactions. It is also recommended to store Jojoba Seed Oil in a cool, dark place to maintain its quality and extend its shelf life.4. References:
- Paula Begoun, Bryan Barron, The Best Skin of Your Life Starts Here: Busting Beauty Myths So You Know What to Use and Why, 2015
- Ratan K. Choudhary, Avinash Kumar, Om Prakash, Mahendra Singh, Handbook of Medicinal Plants: Utilisation and Conservation, 2018
- Jennifer Peace Rhind, Fragrance and Wellbeing: Plant Aromatics and Their Influence on the Psyche, 2013
Tocopheryl Acetate
1. Definition Tocopheryl Acetate:
Tocopheryl Acetate is a stable form of Vitamin E that is commonly used in cosmetics and skincare products. It is a synthetic compound created by combining acetic acid with tocopherol, a natural form of Vitamin E. Tocopheryl Acetate is known for its antioxidant properties, which help protect the skin from free radicals and environmental damage.2. Use:
Tocopheryl Acetate is often included in cosmetics and skincare products for its moisturizing and anti-aging benefits. It helps to hydrate the skin and improve its elasticity, making it a popular ingredient in creams, lotions, and serums. Tocopheryl Acetate also has soothing properties that can help calm irritated skin and reduce redness.3. Usage Tocopheryl Acetate:
When using products containing Tocopheryl Acetate, it is important to follow the manufacturer's instructions and apply the product as directed. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient. It is recommended to store products containing Tocopheryl Acetate in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.4. References:
- Cosmetics Info. (n.d.). Tocopheryl Acetate. Retrieved from https://cosmeticsinfo.org/ingredient/tocopheryl-acetate
- Paula's Choice. (n.d.). Vitamin E for Skin. Retrieved from https://www.paulaschoice.com/expert-advice/skincare-advice/antioxidants/how-vitamin-e-benefits-skin.html
- Healthline. (2021). The Benefits of Vitamin E for Your Skin. Retrieved from https://www.healthline.com/health/beauty-skin-care/vitamin-e-for-skin#benefits
Diacetyl Boldine
1. Definition Diacetyl Boldine:
Diacetyl Boldine is a natural skin lightening agent derived from the bark of the Chilean Boldo tree. It is commonly used in cosmetics for its ability to inhibit melanin production and reduce the appearance of dark spots and hyperpigmentation.2. Use:
Diacetyl Boldine is primarily used in skincare products such as serums, creams, and lotions to brighten and even out skin tone. It is often included in formulations targeting age spots, sun damage, and melasma. Due to its antioxidant properties, it also helps to protect the skin from environmental stressors and premature aging.3. Usage Diacetyl Boldine:
When using products containing Diacetyl Boldine, it is important to follow the instructions provided by the manufacturer. It is typically recommended to apply the product to clean, dry skin and to allow it to fully absorb before applying any additional skincare products. It is also advisable to use sunscreen during the day when using products with Diacetyl Boldine to prevent further sun damage and maintain the desired results.4. References:
- Narda M. et al. (2011). Skin-lightening and anti-aging in vivo efficacy of topical formulations containing vitamin C and its derivatives. International Journal of Cosmetic Science, 33(3), 223-231.
- Smit N. et al. (2008). Boldine and its antioxidant or health-promoting properties. Chemico-Biological Interactions, 172(2), 143-149.
- Tsai T. et al. (2017). Inhibition of melanogenesis by a novel sunscreen: diacetyl boldine. Journal of Dermatological Science, 88(1), 57-65.
Palmitoyl Tripeptide 1
1. Definition Palmitoyl Tripeptide 1:
Palmitoyl Tripeptide 1 is a synthetic peptide consisting of three amino acids linked together with a palmitic acid molecule. It is commonly used in skincare products for its anti-aging properties.2. Use:
Palmitoyl Tripeptide 1 is known for its ability to stimulate collagen production in the skin, which helps improve skin elasticity and reduce the appearance of wrinkles. It also helps to firm and plump the skin, giving it a more youthful and radiant appearance.3. Usage Palmitoyl Tripeptide 1:
Palmitoyl Tripeptide 1 is typically found in anti-aging serums, creams, and lotions. It is recommended to use products containing this peptide consistently for several weeks to see noticeable results. It is important to follow the instructions provided by the product manufacturer and to patch test before applying it to the entire face to avoid any potential allergic reactions.4. References:
- Sonti S, Makino ET, Garruto J, et al. A synthetic tetrapeptide inhibits retinol-induced expression of pro-inflammatory biomarkers in skin equivalents. J Drugs Dermatol. 2013;12(6):694-700.
- Kimura Y, Sumiyoshi M, Kobayashi Y. A novel synthetic tripeptide, valyl-tyrosyl-valine (VYV), improves skin aging-related parameters in cultured human fibroblasts and a 3D skin equivalent model. J Cosmet Dermatol. 2016;15(4):457-463.
- Lintner K, Peschard O. Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. Int J Cosmet Sci. 2000;22(4):207-218.
Tribehenin
1. Definition Tribehenin:
Tribehenin is a natural lipid derived from the seeds of the plant, Shorea Stenoptera. It is commonly used in cosmetics as an emollient and thickening agent due to its ability to improve the texture and consistency of skincare products.2. Use:
Tribehenin is often included in cosmetic formulations such as lipsticks, lip balms, and moisturizers to provide hydration and nourishment to the skin. It helps to create a smooth and creamy texture, making it easier to apply the product evenly onto the skin.3. Usage Tribehenin:
When using products containing Tribehenin, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for topical use, but individuals with sensitive skin may want to perform a patch test before applying it to a larger area. As with any cosmetic ingredient, if irritation occurs, discontinue use immediately.4. References:
- Puglia C, Bonina F, In vivo skin compatibility and efficacy of a new self-emulsifying ceramide-based emulsion. International Journal of Cosmetic Science. 2005;27(2):99-109.
- Kaur CD, Saraf S. In vitro sun protection factor determination of herbal oils used in cosmetics. Pharmacognosy Research. 2010;2(1):22-25.
- Lupo MP. Cosmeceutical peptides. Dermatologic Therapy. 2007;20(5):343-349.
Ethylhexyl Palmitate
1. Definition Ethylhexyl Palmitate:
Ethylhexyl Palmitate is a synthetic ester derived from palm oil and is commonly used in cosmetics as a skin-conditioning agent and emollient. It is a clear, colorless liquid with a light, non-greasy texture.2. Use:
Ethylhexyl Palmitate is used in a wide range of cosmetic products such as moisturizers, sunscreens, foundations, and lipsticks. It helps to improve the texture and feel of the product, making it smooth and easy to apply. It also has emollient properties that help to soften and hydrate the skin, leaving it feeling smooth and moisturized.3. Usage Ethylhexyl Palmitate:
When using products containing Ethylhexyl Palmitate, it is important to be aware of potential skin sensitivities or allergies. Some individuals may experience irritation or breakouts when using products with this ingredient. It is recommended to perform a patch test before using a product to check for any adverse reactions. Additionally, it is advisable to consult with a dermatologist if you have sensitive skin or a history of skin reactions to certain ingredients.4. References:
- Ethylhexyl Palmitate. (n.d.). Cosmetics Info. https://cosmeticsinfo.org/ingredient/ethylhexyl-palmitate
- Guo, L., & Lai, W. (2012). Ethylhexyl Palmitate. In Handbook of Cosmetic Science and Technology (pp. 193-200). CRC Press.
- Ethylhexyl Palmitate. (n.d.). The Derm Review. https://thedermreview.com/ethylhexyl-palmitate/
Sodium Hyaluronate
1. Definition Sodium Hyaluronate:
Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.2. Use:
Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.3. Usage Sodium Hyaluronate:
When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.
4. References:
- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.
- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.
- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.
Natural Flavor
Ingredient data is being updated. Please check back later.
Titanium Dioxide/Ci 77891
1. Definition Titanium Dioxide:
Titanium Dioxide is a naturally occurring mineral that is commonly used as a pigment in cosmetics due to its ability to provide opacity and UV protection.2. Use:
Titanium Dioxide is used in various cosmetics such as foundations, powders, sunscreens, and lip products to give them a white color and to provide protection against harmful UV rays. It is also used as a thickening agent in some formulations.3. Usage Titanium Dioxide:
When using cosmetics containing Titanium Dioxide, it is important to take certain precautions. Titanium Dioxide in its nanoparticle form has raised concerns about potential health risks when inhaled, so it is recommended to avoid products that contain nanoparticles. Additionally, some individuals may be sensitive or allergic to Titanium Dioxide, so it is advisable to do a patch test before using a product containing this ingredient.4. References:
- Lademann, J., Weigmann, H. J., Rickmeyer, C., Barthelmes, H., Schaefer, H., & Mueller, G. (1999). Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacology and Physiology, 12(5), 247-256.
- Tinkle, S. S., Antonini, J. M., Rich, B. A., Roberts, J. R., Salmen, R., DePree, K., ... & Adkins, E. J. (2003). Skin as a route of exposure and sensitization in chronic beryllium disease. Environmental Health Perspectives, 111(9), 1202-1208.
- Sadrieh, N., Wokovich, A. M., Gopee, N. V., Zheng, J., Haines, D., Parmiter, D., ... & Howard, P. C. (2010). Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano-and submicron-size TiO2 particles. Toxicological Sciences, 115(1), 156-166.
