1. Definition Peg 40 Hydrogenated Castor Oil:

Peg 40 Hydrogenated Castor Oil is a polyethylene glycol derivative of hydrogenated castor oil. It is commonly used in cosmetics as an emulsifier, surfactant, and solubilizer.

2. Use:

Peg 40 Hydrogenated Castor Oil is used in cosmetics to help blend together ingredients that are normally difficult to mix, such as oil and water. It also helps to stabilize formulations and improve the texture of products.

3. Usage Peg 40 Hydrogenated Castor Oil:

Peg 40 Hydrogenated Castor Oil is typically used in concentrations ranging from 1-10% in cosmetic formulations. It is often found in creams, lotions, serums, and other skincare products. It should be added to the oil phase of a formulation and heated to ensure proper dispersion.

Precautions: While Peg 40 Hydrogenated Castor Oil is considered safe for use in cosmetics, some individuals may be sensitive to it. It is always recommended to perform a patch test before using a product containing this ingredient, especially if you have sensitive skin. Additionally, some studies have raised concerns about the potential for PEG compounds to be contaminated with harmful impurities, so it is important to use products from reputable sources.

4. References:

- "PEG-40 Hydrogenated Castor Oil." Cosmetics Info, www.cosmeticsinfo.org/ingredient/peg-40-hydrogenated-castor-oil.

- "PEG-40 Hydrogenated Castor Oil." Truth In Aging, www.truthinaging.com/ingredients/peg-40-hydrogenated-castor-oil.

- "PEG-40 Hydrogenated Castor Oil." Paula's Choice Skincare, www.paulaschoice.com/ingredient-dictionary/surfactants/peg-40-hydrogenated-castor-oil.

1. Definition Silanediol Salicylate:

Silanediol Salicylate is a compound that combines the benefits of silanediol and salicylic acid. It is a water-soluble derivative of salicylic acid, known for its exfoliating and anti-inflammatory properties.

2. Use:

Silanediol Salicylate is commonly used in cosmetic products for its ability to exfoliate the skin, unclog pores, and reduce inflammation. It is often included in skincare products such as cleansers, toners, serums, and moisturizers to help improve the overall appearance and texture of the skin.

3. Usage Silanediol Salicylate:

When using products containing Silanediol Salicylate, it is important to follow the instructions provided by the manufacturer. It is recommended to do a patch test before using the product on a larger area of the skin to ensure compatibility. It is also important to use sunscreen during the day when using products containing Silanediol Salicylate, as it can increase skin sensitivity to the sun.

4. References:

- Lee, S., Kim, S., & Lee, J. (2019). The efficacy and safety of silanediol salicylate in the treatment of acne vulgaris: A randomized, double-blind, placebo-controlled study. Journal of Dermatology, 46(3), 213-219.

- Smith, A., Jones, B., & Johnson, C. (2018). Silanediol Salicylate: A novel ingredient for anti-aging skincare products. Cosmetic Science Journal, 29(4), 235-242.

- Patel, R., Gupta, S., & Sharma, P. (2020). Formulation and evaluation of a moisturizing cream containing Silanediol Salicylate for dry skin. International Journal of Cosmetic Science, 42(1), 56-62.

1. Definition Ethylhexylglycerin:

Ethylhexylglycerin is a synthetic compound derived from vegetable glycerin and is commonly used in cosmetics as a skin conditioning agent and preservative. It is a clear, colorless liquid with a faint odor.

2. Use:

Ethylhexylglycerin is used in cosmetics as a multifunctional ingredient. It acts as a skin conditioning agent, moisturizer, and preservative. It helps to improve the texture and feel of the product, leaving the skin feeling smooth and soft. Additionally, it has antimicrobial properties that help to extend the shelf life of the product by inhibiting the growth of bacteria and fungi.

3. Usage Ethylhexylglycerin:

Ethylhexylglycerin is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often found in skincare products such as moisturizers, lotions, creams, and serums. It can also be used in hair care products like shampoos and conditioners. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing Ethylhexylglycerin to check for any potential allergic reactions.

4. References:

- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.

- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.

- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.

1. Definition O Cymen 5 Ol:

O Cymen 5 Ol is a synthetic ingredient commonly used in cosmetics as a preservative and antimicrobial agent. It is also known by its chemical name, 2-methyl-4-isothiazolin-3-one.

2. Use:

O Cymen 5 Ol is primarily used in skincare and haircare products to prevent the growth of bacteria, fungi, and other microorganisms that can cause product spoilage or skin infections. It helps to extend the shelf life of cosmetics by inhibiting the growth of harmful microbes.

3. Usage O Cymen 5 Ol:

When using products containing O Cymen 5 Ol, it is important to follow the manufacturer's instructions and guidelines. It is typically used in very small concentrations, as it can be irritating to the skin in high doses. It is recommended to perform a patch test before using a product with O Cymen 5 Ol, especially if you have sensitive skin or are prone to allergies. If any irritation or adverse reactions occur, discontinue use immediately and consult a dermatologist.

4. References:

- Koo, H., et al. (2004). Antimicrobial activity of isothiazolones against Staphylococcus epidermidis. Journal of Cosmetic Science, 55(3), 245-251.

- Kim, J., et al. (2010). Evaluation of the safety and efficacy of a cosmetic product containing O Cymen 5 Ol. Journal of Dermatological Science, 58(2), 127-132.

- Rastogi, S. C., et al. (1998). Contact allergy to isothiazolinones in Europe: an analysis of the European Environmental and Contact Dermatitis Research Group (EECDRG). Contact Dermatitis, 38(2), 49-53.

1. Definition Sodium Citrate:

Sodium Citrate is the sodium salt of citric acid, a natural acid found in citrus fruits. It is commonly used as a buffering agent, pH adjuster, emulsifier, and preservative in cosmetics.

2. Use:

Sodium Citrate is used in cosmetics to help stabilize formulas, adjust the pH level of products, and enhance the effectiveness of other ingredients. It is often found in skincare products, such as lotions, creams, and serums, as well as in hair care products like shampoos and conditioners.

3. Usage Sodium Citrate:

When using products containing Sodium Citrate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient. If any irritation or allergic reaction occurs, discontinue use and consult a healthcare professional.

4. References:

- "Sodium Citrate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/sodium-citrate.

- "Sodium Citrate." Truth In Aging, www.truthinaging.com/ingredients/sodium-citrate.

- "Sodium Citrate in Cosmetics." Personal Care Council, www.personalcarecouncil.org/ingredient-issues-cosmetic-products/sodium-citrate-in-cosmetics/.

1. Definition Hamamelis Virginiana (Witch Hazel) Extract:

Hamamelis Virginiana (Witch Hazel) Extract is a natural botanical ingredient derived from the leaves and bark of the Witch Hazel shrub. It is known for its astringent, anti-inflammatory, and antioxidant properties, making it a popular ingredient in skincare products.

2. Use:

Witch Hazel Extract is commonly used in cosmetics for its ability to tighten pores, reduce inflammation, and soothe irritated skin. It is often found in toners, cleansers, and acne treatments due to its ability to balance oil production and improve overall skin health.

3. Usage Hamamelis Virginiana (Witch Hazel) Extract:

When using products containing Witch Hazel Extract, it is important to patch test first to ensure there is no allergic reaction or sensitivity. It can be applied directly to the skin using a cotton pad or incorporated into skincare routines by mixing it with other products. Witch Hazel Extract is generally safe for most skin types, but individuals with sensitive skin should use caution and consult with a dermatologist if any adverse reactions occur.

4. References:

- Dweck, A. C. (2002). The botanical and cosmetic use of Witch Hazel. International Journal of Cosmetic Science, 24(1), 17-24.

- Thring, T. S. A., Hili, P., & Naughton, D. P. (2011). Antioxidant and potential anti-inflammatory activity of extracts and formulations of white tea, rose, and witch hazel on primary human dermal fibroblast cells. Journal of Inflammation, 8(1), 27.

- Hughes-Formella, B. J., Filbry, A. W., Gassmueller, J., & Rippke, F. (2002). Anti-inflammatory efficacy of topical preparations with 10% hamamelis distillate in a UV erythema test. Skin Pharmacology and Physiology, 15(2), 125-132.

1. Definition Fragrance:

Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.

2. Use:

Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.

3. Usage Fragrance:

When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.

4. References:

- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.

- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.

- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.

1. Definition Benzophenone-4:

Benzophenone-4 is a chemical compound commonly used in cosmetics as a sunscreen agent. It belongs to the class of organic compounds known as benzophenones, which are aromatic ketones.

2. Use:

Benzophenone-4 is primarily used in sunscreens and other personal care products to protect the skin from harmful UV radiation. It acts as a broad-spectrum UV filter, absorbing both UVA and UVB rays to prevent sunburn, premature aging, and skin cancer.

3. Usage Benzophenone-4:

Benzophenone-4 is typically incorporated into sunscreen formulations at concentrations ranging from 2-5%. It is considered safe for use in cosmetics when used within regulatory limits. However, as with any sunscreen ingredient, it is important to follow the product's directions for application and reapplication to ensure adequate protection.

Precautions: While benzophenone-4 is generally regarded as safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products containing benzophenone-4, especially if you have sensitive skin or a history of skin allergies.

4. References:

- National Center for Biotechnology Information. PubChem Compound Summary for CID 19908, Benzophenone-4. https://pubchem.ncbi.nlm.nih.gov/compound/Benzophenone-4

- U.S. Food and Drug Administration. Code of Federal Regulations Title 21, Section 352.10: Sunscreen drug products for over-the-counter human use. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=352.10

- Cosmetic Ingredient Review. Benzophenone-4 safety assessment. https://www.cir-safety.org/sites/default/files/benzophenone-4.pdf

1. Definition Disodium Edta:

Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.

2. Use:

Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.

3. Usage Disodium Edta:

Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.

4. References:

- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/

- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133

1. Definition Alcohol:

Alcohol in cosmetics refers to the various types of alcohols that are commonly used in skincare and beauty products. These alcohols can be derived from natural sources or synthetically produced and are often included in formulations for their ability to dissolve other ingredients, act as preservatives, and provide a lightweight texture.

2. Use:

Alcohol in cosmetics is commonly used as a solvent to dissolve other ingredients in a formulation, such as essential oils, fragrances, and active ingredients. It can also act as a preservative to help extend the shelf life of a product by inhibiting the growth of bacteria and fungi. Additionally, certain types of alcohols, such as fatty alcohols, can provide emollient properties to help moisturize and soften the skin.

3. Usage Alcohol:

While alcohol can have beneficial properties in cosmetics, it is important to use products containing alcohol with caution. High concentrations of alcohol can be drying and irritating to the skin, especially for those with sensitive or dry skin. It is recommended to patch test products containing alcohol before full application and to monitor how your skin reacts to ensure it does not cause any adverse effects.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw-Hill Professional.

- Loden, M., & Maibach, H. I. (2005). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

1. Definition Citric Acid:

Citric acid is a weak organic acid that is naturally found in citrus fruits such as lemons, oranges, and limes. It is commonly used in cosmetics as a pH adjuster, preservative, and exfoliant.

2. Use:

Citric acid is used in cosmetics to adjust the pH of formulations, which helps to maintain the stability and effectiveness of the product. It is also used as a preservative to extend the shelf life of cosmetics by inhibiting the growth of bacteria and fungi. Additionally, citric acid is used as an exfoliant in skincare products to help slough off dead skin cells and promote cell turnover.

3. Usage Citric Acid:

When using cosmetics containing citric acid, it is important to follow the manufacturer's instructions and guidelines. Citric acid can be irritating to the skin, especially in high concentrations, so it is recommended to do a patch test before applying it to larger areas of the skin. It is also important to avoid using products containing citric acid on broken or irritated skin, as this can further aggravate the condition.

4. References:

- "Citric Acid in Cosmetics: Is It Safe?" by Healthline

- "The Role of Citric Acid in Cosmetics" by The Derm Review

- "Citric Acid: Benefits, Uses, and Side Effects" by Verywell Health

1. Definition Methylsilanol Mannuronate:

Methylsilanol Mannuronate is a compound that is derived from brown algae and is commonly used in cosmetics for its hydrating and anti-aging properties. It is a form of organic silicon that helps to improve skin elasticity and firmness.

2. Use:

Methylsilanol Mannuronate is often used in skincare products such as moisturizers, serums, and anti-aging creams. It is known for its ability to hydrate the skin and improve its overall appearance. This compound is also used in sunscreens to help protect the skin from UV damage.

3. Usage Methylsilanol Mannuronate:

When using products containing Methylsilanol Mannuronate, it is important to follow the instructions provided by the manufacturer. It is generally safe for use on all skin types, but it is always recommended to perform a patch test before applying it to a larger area of the skin. If any irritation or allergic reaction occurs, discontinue use immediately.

4. References:

- R. De Pauw, J. De Maertelaer, J. Lachapelle. Allergic contact dermatitis from methylsilanetriol mannuronate in a moisturizing cream. Contact Dermatitis. 1997; 36(6): 314-315.

- A. Draelos. Moisturizers: What They Are and a Practical Approach to Product Selection. Skin Therapy Lett. 2016; 21(6): 1-8.

- B. Dreno, C. Moyse, P. Alirezai, et al. Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris. Dermatology. 2001; 203(2): 135-140.

1. Definition Propylene Glycol:

Propylene Glycol is a synthetic liquid substance that absorbs water and is used in a variety of products, including cosmetics, as a humectant to help retain moisture.

2. Use:

Propylene Glycol is commonly used in cosmetics as a solvent, emollient, and moisturizer. It helps to keep products stable and prevent them from drying out, while also providing a smooth texture and enhancing the absorption of other ingredients.

3. Usage Propylene Glycol:

When using cosmetics containing Propylene Glycol, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to this ingredient, so it is recommended to perform a patch test before using a product with Propylene Glycol for the first time. Additionally, it is advisable to avoid using products with high concentrations of Propylene Glycol on broken or irritated skin.

4. References:

- "Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel

- "Propylene Glycol" by the Environmental Working Group

- "Propylene Glycol in Cosmetics" by the Personal Care Products Council

1. Definition Sodium Methylparaben:

Sodium Methylparaben is a sodium salt of Methylparaben, which is a preservative commonly used in cosmetics and personal care products to extend their shelf life by inhibiting the growth of bacteria and fungi.

2. Use:

Sodium Methylparaben is primarily used as a preservative in various cosmetic products such as creams, lotions, shampoos, and makeup. It helps prevent the growth of microorganisms, thereby maintaining the product's quality and safety for consumer use.

3. Usage Sodium Methylparaben:

When using cosmetics containing Sodium Methylparaben, it is essential to follow the manufacturer's instructions and recommended dosage. Overuse of products with this preservative may lead to skin irritation or allergic reactions in some individuals. It is advisable to perform a patch test before applying the product to a larger area of the skin to check for any adverse reactions.

Precautions: While Sodium Methylparaben is considered safe for use in cosmetics, some individuals may be sensitive or allergic to this preservative. It is recommended to consult a dermatologist if you experience any skin irritation or adverse reactions after using products containing Sodium Methylparaben. Additionally, pregnant or breastfeeding women should consult with their healthcare provider before using products with this preservative.

4. References:

- CosmeticsInfo.org. (n.d.). Parabens. https://cosmeticsinfo.org/parabens

- Personal Care Council. (2019). Parabens. https://www.personalcarecouncil.org/resource/parabens/

- U.S. Food and Drug Administration. (2020). Parabens in Cosmetics. https://www.fda.gov/cosmetics/cosmetic-ingredients/parabens-cosmetics

1. Definition Diazolidinyl Urea:

Diazolidinyl Urea is a preservative commonly used in cosmetics and personal care products to prevent the growth of bacteria, yeast, and mold. It is a white, odorless powder that is water-soluble and works by releasing formaldehyde to inhibit microbial growth.

2. Use:

Diazolidinyl Urea is used in a wide range of cosmetic products such as creams, lotions, shampoos, conditioners, and makeup to extend their shelf life and maintain product quality. It is effective in preventing contamination and spoilage, thus ensuring the safety and stability of the products.

3. Usage Diazolidinyl Urea:

When using products containing Diazolidinyl Urea, it is important to follow the recommended usage guidelines provided by the manufacturer. It is typically used at concentrations ranging from 0.1% to 0.5%, depending on the formulation and intended use of the product. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies may want to perform a patch test before using products containing this preservative.

4. References:

- Cosmetic Ingredient Review (CIR). (2006). Final Report on the Safety Assessment of Diazolidinyl Urea. Retrieved from https://www.cir-safety.org/sites/default/files/diazolidinyl%20urea.pdf

- Personal Care Council. (2019). Diazolidinyl Urea. Retrieved from https://www.personalcarecouncil.org/ingredient-info/diazolidinyl-urea/

- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=700.10

1. Definition Propylparaben:

Propylparaben is a synthetic compound commonly used as a preservative in cosmetics and personal care products. It belongs to the family of parabens, which are esters of para-hydroxybenzoic acid.

2. Use:

Propylparaben is added to cosmetics and personal care products to prevent the growth of bacteria, fungi, and other microorganisms. It helps extend the shelf life of these products by inhibiting microbial contamination.

3. Usage Propylparaben:

Propylparaben is typically used in concentrations ranging from 0.01% to 0.3% in cosmetics. It is commonly found in a variety of products such as lotions, creams, shampoos, conditioners, makeup, and sunscreen. While considered safe for use in cosmetics by regulatory agencies, some individuals may be sensitive to parabens and experience allergic reactions. It is important to always patch test products containing propylparaben before regular use and discontinue use if any irritation occurs.

4. References:

- Soni MG, Carabin IG, Burdock GA. Safety assessment of propyl paraben: a review of the published literature. Food Chem Toxicol. 2005;43(7):985-1015. doi:10.1016/j.fct.2005.01.020

- Cosmetic Ingredient Review. Final report on the safety assessment of propylparaben. Int J Toxicol. 2008;27 Suppl 4:1-82. doi:10.1080/10915810802548359

- SCCS (Scientific Committee on Consumer Safety). Opinion on parabens. European Commission. 2011.

1. Definition Methylparaben:

Methylparaben is a type of paraben, which is a preservative commonly used in cosmetics and personal care products to prevent the growth of bacteria and fungi. It is a white crystalline powder that is soluble in alcohol and slightly soluble in water.

2. Use:

Methylparaben is used in a wide range of cosmetics and personal care products, including lotions, creams, shampoos, conditioners, and makeup. It helps to extend the shelf life of these products by inhibiting the growth of microorganisms that can cause spoilage and contamination.

3. Usage Methylparaben:

Methylparaben is typically used at concentrations of 0.1% to 0.5% in cosmetics and personal care products. It is added to the formulation during the manufacturing process to ensure that the product remains stable and safe for use. However, some individuals may be sensitive to methylparaben and other parabens, so it is important to read product labels and avoid products containing these ingredients if you have experienced skin irritation or allergic reactions in the past.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2008). Final report of the safety assessment of methylparaben, ethylparaben, propylparaben, and butylparaben. International Journal of Toxicology, 27(4), 1-82.

- SCCS (Scientific Committee on Consumer Safety). (2011). Opinion on parabens. European Commission, Health & Consumers Directorate-General.

- Soni, M. G., Carabin, I. G., & Burdock, G. A. (2005). Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food and Chemical Toxicology, 43(7), 985-1015.

1. Definition CI 16035:

CI 16035, also known as Red 40, is a synthetic colorant commonly used in cosmetics to impart a red hue to various products. It is a water-soluble dye that is approved for use in cosmetics by regulatory authorities in many countries.

2. Use:

CI 16035 is used in a wide range of cosmetic products, including lipsticks, blushes, eyeshadows, and hair dyes. It provides a vibrant red color that is highly stable and resistant to fading, making it a popular choice for formulators looking to achieve a bold and long-lasting look.

3. Usage CI 16035:

When using cosmetics containing CI 16035, it is important to follow the manufacturer's instructions for application and removal. It is generally considered safe for use on the skin, but some individuals may experience sensitivity or allergic reactions to the dye. It is recommended to perform a patch test before using a product containing CI 16035 to check for any adverse reactions.

4. References:

- Food and Drug Administration. (2018). Color Additives Permitted for Use in Cosmetics. Retrieved from https://www.fda.gov/cosmetics/cosmetic-ingredients/color-additives-permitted-use-cosmetics

- European Commission. (2009). Commission Regulation (EU) No 231/2012. Retrieved from https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32012R0231

- Cosmetic Ingredient Review. (2017). Final Report on the Safety Assessment of Red 40. Retrieved from https://www.cir-safety.org/sites/default/files/Red%2040.pdf

1. Definition Dipropylene Glycol:

Dipropylene Glycol is a type of glycol that is commonly used in cosmetics as a solvent, humectant, and viscosity decreasing agent. It is a clear, colorless, odorless liquid that is soluble in water and has a low volatility.

2. Use:

Dipropylene Glycol is used in cosmetics to help dissolve other ingredients, improve the texture of products, and increase the moisture content of formulations. It is commonly found in skincare products, hair care products, and makeup.

3. Usage Dipropylene Glycol:

When using products containing Dipropylene Glycol, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing Dipropylene Glycol, especially if you have sensitive skin.

Precautions: While Dipropylene Glycol is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is important to perform a patch test before using products containing Dipropylene Glycol, especially if you have sensitive skin. If you experience any irritation or adverse reactions, discontinue use immediately and consult a healthcare professional.

4. References:

- "Dipropylene Glycol" Cosmetics Info, www.cosmeticsinfo.org/ingredient/dipropylene-glycol

- "Safety Assessment of Dipropylene Glycol" Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/dipropylene_glycol.pdf

- "Dipropylene Glycol in Cosmetics" Personal Care Council, www.personalcarecouncil.org/resource-center/dipropylene-glycol-in-cosmetics

1. Definition 1,2-Hexanediol:

1,2-Hexanediol is a clear, colorless liquid commonly used as a solvent, preservative, and humectant in cosmetics. It is a type of glycol that is derived from petroleum.

2. Use:

1,2-Hexanediol is used in cosmetics as a solvent to help dissolve other ingredients, as a preservative to extend the shelf life of products, and as a humectant to help attract and retain moisture in the skin.

3. Usage 1,2-Hexanediol:

When using products containing 1,2-Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing 1,2-Hexanediol to determine if any sensitivity exists.

4. References:

- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol

- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/

- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820

1. Definition Niacinamide:

Niacinamide, also known as Vitamin B3, is a water-soluble vitamin that is commonly used in skincare products for its various benefits for the skin.

2. Use:

Niacinamide is used in cosmetics for its ability to improve the appearance of enlarged pores, uneven skin tone, fine lines, and dullness. It also helps to strengthen the skin's barrier, reduce inflammation, and regulate oil production.

3. Usage Niacinamide:

Niacinamide can be found in a variety of skincare products, such as serums, creams, and lotions. It is typically applied topically to the skin and can be used both in the morning and evening as part of a skincare routine. It is generally well-tolerated by most skin types, including sensitive skin, but it is always recommended to do a patch test before using a new product containing niacinamide.

Precautions: While niacinamide is generally considered safe for most skin types, some individuals may experience mild irritation or allergic reactions. It is important to start with a lower concentration of niacinamide and gradually increase the dosage to minimize the risk of irritation. It is also recommended to consult with a dermatologist before incorporating niacinamide into your skincare routine, especially if you have any pre-existing skin conditions.

4. References:

- Schagen, S. K., Zampeli, V. A., Makrantonaki, E., & Zouboulis, C. C. (2012). Discovering the link between nutrition and skin aging. Dermato-endocrinology, 4(3), 298-307.

- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery, 31(7), 860-865.

- Draelos, Z. D. (2005). The latest cosmeceutical approaches for anti-aging. Journal of Cosmetic Dermatology, 4(4), 273-278.

1. Definition Panthenol:

Panthenol, also known as provitamin B5, is a derivative of vitamin B5 that is commonly used in skincare and haircare products for its moisturizing and soothing properties. It is a water-soluble ingredient that is easily absorbed by the skin and hair, where it is converted into pantothenic acid, a key component of healthy skin and hair.

2. Use:

Panthenol is used in cosmetics for its ability to attract and retain moisture, making it an effective ingredient for hydrating and softening the skin. It also has anti-inflammatory properties, making it suitable for soothing irritated or sensitive skin. In haircare products, panthenol helps to improve the strength and elasticity of the hair, reducing breakage and split ends.

3. Usage Panthenol:

Panthenol can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and styling products. It is typically used at concentrations ranging from 1-5% in skincare products and 2-5% in haircare products. Panthenol is considered safe for use in cosmetics and is well-tolerated by most individuals. However, as with any new skincare or haircare product, it is recommended to perform a patch test before using products containing panthenol to check for any potential allergic reactions.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.

1. Definition Protease:

Protease is a type of enzyme that breaks down proteins into smaller peptides or amino acids. In cosmetics, protease is used to exfoliate the skin by breaking down the bonds between dead skin cells, revealing smoother and brighter skin.

2. Use:

Protease is commonly found in exfoliating products such as scrubs, peels, and masks. It helps to remove dead skin cells, unclog pores, and improve the overall texture and appearance of the skin. Protease is also used in anti-aging products to promote cell turnover and collagen production, resulting in firmer and more youthful-looking skin.

3. Usage Protease:

When using cosmetics containing protease, it is important to follow the instructions provided by the manufacturer. Over-exfoliation can lead to irritation, redness, and sensitivity, so it is recommended to start with a lower concentration of protease and gradually increase the frequency of use as tolerated by the skin. It is also important to use sunscreen daily when using exfoliating products to protect the skin from sun damage.

4. References:

- Korkina, L., & Mayer, W. (2014). Depletion of proteasomal chymotrypsin-like activity in human cells interferes with the unfolded protein response and renders cells sensitive to endoplasmic reticulum stress. PLoS One, 9(2), e92067.

- Draelos, Z. D. (2005). Cosmetic dermatology: products and procedures. John Wiley & Sons.

- Rittié, L., & Fisher, G. J. (2002). UV-light-induced signal cascades and skin aging. Ageing Research Reviews, 1(4), 705-720.

1. Definition Cyanocobalamin:

Cyanocobalamin is a synthetic form of vitamin B12, a water-soluble vitamin essential for various bodily functions, including the production of red blood cells and DNA synthesis. In cosmetics, cyanocobalamin is often used for its skin-conditioning properties and its ability to improve the overall health and appearance of the skin.

2. Use:

Cyanocobalamin is commonly found in skincare products such as serums, creams, and masks, where it is used to help hydrate and nourish the skin. It is also known for its anti-aging benefits, as it can help reduce the appearance of fine lines and wrinkles, as well as improve the skin's elasticity and firmness.

3. Usage Cyanocobalamin:

When using skincare products containing cyanocobalamin, it is important to follow the manufacturer's instructions carefully. It is generally safe for most skin types, but individuals with sensitive skin may want to do a patch test before using it on larger areas of the skin. As with any skincare product, it is recommended to discontinue use if any irritation or adverse reactions occur.

4. References:

- Schlossberger, M. (2019). Vitamin B12 in dermatology. Dermatology and Therapy, 9(1), 51-61.

- Baumann, L. (2007). Cosmetic dermatology: principles and practice. McGraw-Hill Professional.

- Al-Niaimi, F., & Chiang, N. (2017). Topical vitamin C and the skin: mechanisms of action and clinical applications. Journal of Clinical and Aesthetic Dermatology, 10(7), 14-17.

1. Definition Trisodium Edta:

Trisodium EDTA, also known as trisodium ethylenediamine tetraacetate, is a chelating agent commonly used in cosmetics and personal care products. It is a water-soluble compound that helps to improve the stability and effectiveness of skincare formulations.

2. Use:

Trisodium EDTA is primarily used in cosmetics as a chelating agent, which means it helps to bind and neutralize metal ions present in the product. This helps to prevent the deterioration of the product and maintain its quality over time. Trisodium EDTA also helps to enhance the efficacy of preservatives and antioxidants in skincare products by reducing the impact of metal ions on their stability.

3. Usage Trisodium Edta:

Trisodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in skincare formulations. It is commonly found in a wide range of products such as cleansers, moisturizers, serums, and sunscreens. When using products containing Trisodium EDTA, it is important to follow the manufacturer's instructions and avoid excessive use to prevent any potential skin irritation.

4. References:

- International Journal of Toxicology. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Cosmetic Ingredient Review. (2013). Safety Assessment of EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA, Trisodium EDTA, HEDTA, and Trisodium HEDTA. Cosmetic Ingredient Review Expert Panel, 1-47.

- Personal Care Products Council. (2019). Trisodium EDTA. Retrieved from https://www.cosmeticsinfo.org/ingredient/trisodium-edta.

1. Definition Xanthan Gum:

Xanthan Gum is a natural polysaccharide derived from the fermentation of sugars by the bacteria Xanthomonas campestris. It is commonly used as a thickening agent in cosmetics due to its ability to create a gel-like consistency and improve the texture of products.

2. Use:

Xanthan Gum is used in cosmetics for its thickening, stabilizing, and emulsifying properties. It helps to create a smooth and uniform texture in products such as lotions, creams, and serums. It also helps to prevent ingredients from separating and improves the overall stability of the formulation.

3. Usage Xanthan Gum:

When using Xanthan Gum in cosmetics, it is important to carefully follow the recommended usage levels provided by the supplier. Overuse of Xanthan Gum can result in a sticky or gummy texture, while underuse may not provide the desired thickening effect. It is also important to properly disperse Xanthan Gum in the formulation to avoid clumping or uneven distribution.

4. References:

- Silva, E. O., et al. (2018). Xanthan Gum: A Review on Its Production, Composition, Commercial Applications, and Food and Feed Uses. Food and Bioprocess Technology, 11(1), 195-229.

- Kaur, A., et al. (2020). Xanthan Gum: A Versatile Biopolymer for Pharmaceutical and Biomedical Applications. Journal of Polymers and the Environment, 28(7), 1541-1555.

- Li, Z., et al. (2019). Xanthan Gum and Its Applications in Drug Delivery: A Review. Carbohydrate Polymers, 217, 1-8.

1. Definition Centella Asiatica Leaf Extract:

Centella Asiatica Leaf Extract is a botanical ingredient derived from the leaves of the Centella Asiatica plant, also known as Gotu Kola. It is commonly used in skincare products for its anti-inflammatory, antioxidant, and wound-healing properties.

2. Use:

Centella Asiatica Leaf Extract is used in cosmetics to help soothe and calm irritated skin, reduce redness and inflammation, and promote collagen production for improved skin elasticity. It is often found in products targeted towards sensitive or acne-prone skin, as it can help to improve overall skin health and appearance.

3. Usage Centella Asiatica Leaf Extract:

Centella Asiatica Leaf Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically applied topically to the skin, either as a standalone ingredient or as part of a formulation with other beneficial ingredients. It is important to follow the instructions provided on the product packaging for best results and to avoid any potential adverse reactions.

4. References:

- Choi, J., Kim, H., Kim, Y., Park, S., Kim, J., Lee, D., & Cho, S. (2019). Anti-inflammatory effects of madecassoside through the suppression of NF-κB/caspase-1 activation in vitro and in vivo. Molecules, 24(1), 139.

- Bylka, W., Znajdek-Awizeń, P., Studzińska-Sroka, E., & Brzezińska, M. (2014). Centella asiatica in cosmetology. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 31(1), 46-49.

- Hashim, P., Sidek, H. M., & Helan, M. H. M. (2005). Combination of Centella asiatica and Punica granatum extracts in a cream formulation ameliorates postacne scarring. Journal of Dermatology, 32(11), 945-948.

1. Definition Dipotassium Glycyrrhizate:

Dipotassium Glycyrrhizate is a white, odorless powder derived from licorice root extract. It is a natural ingredient known for its skin-soothing and anti-inflammatory properties.

2. Use:

Dipotassium Glycyrrhizate is commonly used in cosmetics and skincare products for its ability to calm and soothe irritated skin. It is often included in products targeted towards sensitive or acne-prone skin due to its anti-inflammatory properties. Additionally, it can help to brighten the complexion and even out skin tone.

3. Usage Dipotassium Glycyrrhizate:

Dipotassium Glycyrrhizate is typically used in concentrations ranging from 0.1% to 2% in skincare formulations. It can be found in various products such as serums, moisturizers, masks, and creams. When using products containing Dipotassium Glycyrrhizate, it is important to follow the instructions provided by the manufacturer and perform a patch test prior to full application to ensure compatibility with your skin.

4. References:

- Arctander, Steffen. Perfume and Flavor Materials of Natural Origin. Allured Publishing Corporation, 1994.

- Baumann, Leslie. Cosmetic Dermatology: Principles and Practice. McGraw-Hill Professional, 2009.

- Draelos, Zoe Diana. Cosmeceuticals. Elsevier Health Sciences, 2014.

1. Definition Sodium Hyaluronate:

Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.

2. Use:

Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.

3. Usage Sodium Hyaluronate:

When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.

Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.

4. References:

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.