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| EWG | CIR | Ingredient Name & Cosmetic Function | Notes |
|---|---|---|---|
| 1 2 | A | (Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant ) | Good for dry skin Moisturizing |
| 2 4 | A | (Fragrance, Preservative) | |
| 1 3 | A | (Skin Protecting, Skin Conditioning, Emollient, Antifoaming Agent) | Moisturizing |
| 1 | A | (Humectant, Hair Conditioning, Skin Conditioning, Emollient) | |
| 1 | A | (Chelating Agent, Viscosity Controlling) | |
| 1 | A | (Skin Conditioning, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Binding, Surfactant - Emulsifying Agent, Gel Forming) | |
| 1 | A | (Solvent, Masking, Fragrance, Humectant, Skin Conditioning, Viscosity Controlling, Viscosity decreasing agents) | Good for dry skin |
| 3 | B | (Solvent, Fragrance, Humectant, Viscosity Decreasing Agent, Skin Conditioning, Viscosity Controlling, Skin-Conditioningagent - Miscellaneous) | Good for dry skin |
| 1 | A | (Opacifying, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Foam Boosting, Viscosity Increasingagent - Aqueous) | Cleansing |
| 3 | A | (Solvent, Hair Conditioning, Skin Conditioning, Emollient) | |
| 1 | A | (Masking, Fragrance, Opacifying, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Foam Boosting, Surfactant) | Cleansing |
| 1 | A | (Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Gel Forming) | |
| 3 | A | (Preservative, Antimicrobial, Cosmetic Biocide) | |
| 1 | A | (Skin Conditioning, Emollient, Antimicrobial) | |
| 1 3 | A | (Surfactant) | Fungal Acne Trigger Cleansing |
| 2 | A | (Solvent, Hair Conditioning, Skin Conditioning, Emollient) | |
| 1 3 | B | (Surfactant, Emulsifying, Sufactant) | Cleansing |
| 1 | A | (Uv Absorber, Antioxidant, Anticaries Agent, Antidandruff Agent, Antifungal Agent, Antimicrobial Agent, Sunscreen Agent) | Anti Aging Promotes Wound Healing Good for dry skin |
| 1 | B | (Solvent, Hair Conditioning, Skin Conditioning) | |
| 1 | B | (Skin Conditioning, Emollient) | |
| 2 3 | - | (pH adjusting agent, pH adjusting agent, Denaturant ) | |
| 1 | - | (Skin Conditioning) | Brightening |
| 1 3 | B | (Surfactant, Emulsifying, Cleansing) | Cleansing |
| 3 | A | (Surfactant) | Fungal Acne Trigger Cleansing |
| 2 3 | A | (Preservative, Antioxidant, Hair Waving Or Straightening, Reducing) | |
| 1 | - | (Antioxidant) | |
| 1 | - | (Antioxidant) | |
| 1 | A | (Emollient, Emulsifying) | Fungal Acne Trigger Cleansing |
| 2 3 | A | (Skin Conditioning, Antioxidant) | Anti Aging |
| 2 | - | (Uv Absorber, Uv Filter) | UV Protection |
| 4 | - | (Uv Absorber, Uv Filter) | UV Protection |
| 6 | - | (Uv Absorber, Uv Filter) | UV Protection Bad for sensitive skin Fragrance-free |
| EWG | CIR | Ingredient Name & Cosmetic Function | Notes |
|---|---|---|---|
| 1 | - | (Solvent) | |
| 1 2 | A | (Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant ) | Good for dry skin Moisturizing |
| 3 | B | (Solvent, Fragrance, Humectant, Viscosity Decreasing Agent, Skin Conditioning, Viscosity Controlling, Skin-Conditioningagent - Miscellaneous) | Good for dry skin |
| 2 3 | - | (Uv Absorber, Sunscreen Agent, Uv Filter) | UV Protection |
| 1 3 | - | (Uv Absorber, Uv Filter) | UV Protection |
| 8 | - | (Uv Absorber, Uv Filter) | UV Protection |
| 1 | A | (Hair Conditioning, Skin Conditioning, Smoothing) | Anti Aging Brightening |
| 1 | A | (Emollient, Emulsifying) | Fungal Acne Trigger Cleansing |
| 1 | A | (Masking, Fragrance, Opacifying, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Foam Boosting, Surfactant) | Cleansing |
| 1 | A | (Masking, Fragrance, Opacifying, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Foam Boosting, Surfactant, Refatting) | Cleansing |
| 2 | - | (Uv Absorber, Uv Filter) | UV Protection |
| 1 | B | (Solvent, Perfuming, Fragrance, Skin Conditioning, Emollient, Binding Agent, Binding) | Bad for oily skin Fungal Acne Trigger |
| 1 | A | Bad for oily skin Fungal Acne Trigger | |
| 1 3 | A | (Skin Protecting, Skin Conditioning, Emollient, Antifoaming Agent) | Moisturizing |
| 1 | A | (Skin Conditioning, Emollient) | Promotes Wound Healing Fungal Acne Trigger Good for oily skin |
| 1 3 | B | (Emulsifying, Surfactant, Cleansing) | Cleansing |
| 1 | A | (Hair Conditioning, Skin Conditioning, Antistatic Agent) | Good for dry skin Promotes Wound Healing |
| 1 | A | (Humectant, Hair Conditioning, Skin Conditioning, Emollient) | |
| 2 4 | A | (Fragrance, Preservative) | |
| 1 | A | (Skin Conditioning, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Binding, Surfactant - Emulsifying Agent, Gel Forming) | |
| 1 | A | (Skin Protecting, Skin Conditioning, Soothing) | Good for sensitive skin Good for oily skin Moisturizing |
Glycerin
1. Definition Glycerin:
Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.
2. Use:
Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.
3. Usage Glycerin:
When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.
Phenoxyethanol
1. Definition Phenoxyethanol:
Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.2. Use:
Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.3. Usage Phenoxyethanol:
When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.
Dimethicone
1. Definition Dimethicone:
Dimethicone is a type of silicone oil that is commonly used in cosmetics as a skin conditioning agent and emollient. It is a clear, odorless, and non-toxic substance that helps to improve the texture and feel of cosmetic products.2. Use:
Dimethicone is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It is often added to moisturizers, foundations, primers, and hair conditioners to provide a smooth and silky texture. Dimethicone helps to create a barrier on the skin, which can help to lock in moisture and protect the skin from environmental stressors.3. Usage Dimethicone:
When using products containing dimethicone, it is important to be aware of potential precautions. While dimethicone is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to do a patch test before using a new product containing dimethicone, especially if you have sensitive skin. Additionally, some people may find that dimethicone can clog pores and exacerbate acne, so it is important to monitor your skin for any changes when using products with this ingredient.4. References:
- Lanigan, R. S., & Yamarik, T. A. (2002). Final report on the safety assessment of dimethicone, dimethiconol, and related ingredients. International journal of toxicology, 21(1), 7-41.
- Draelos, Z. D. (2010). Cosmetic vehicle efficacy. Dermatologic therapy, 23(4), 314-317.
- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... & Andersen, F. A. (2016). Safety assessment of dimethicone crosspolymers as used in cosmetics. International journal of toxicology, 35(1_suppl), 5S-24S.
Caprylyl Glycol
1. Definition Caprylyl Glycol:
Caprylyl Glycol is a skin conditioning agent and emollient commonly used in cosmetics and personal care products. It is derived from caprylic acid, which is found in coconut and palm oils.2. Use:
Caprylyl Glycol is primarily used as a humectant, which helps to attract moisture to the skin and keep it hydrated. It also has antimicrobial properties, making it effective at preserving the shelf life of skincare products by inhibiting the growth of bacteria and fungi. Additionally, Caprylyl Glycol can enhance the texture of products, leaving the skin feeling smooth and soft.3. Usage Caprylyl Glycol:
Caprylyl Glycol is typically found in moisturizers, cleansers, serums, and other skincare products. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing Caprylyl Glycol to their entire face. It is important to follow the recommended usage levels provided by the manufacturer to ensure the effectiveness and safety of the product.4. References:
- Monkare J, Maczka W, Matuszak Ż, et al. Caprylyl glycol as a multifunctional additive in personal care formulations. Cosmetics. 2020;7(1):17. doi:10.3390/cosmetics7010017
- Lodeiro C, Margus T, Pinto S, et al. Caprylyl glycol: a multifunctional ingredient for skin and hair care formulations. SOFW J. 2017;143(11):42-48.
- Draelos ZD. The science behind skin care: moisturizers. J Drugs Dermatol. 2013;12(9):s27-s30.
Disodium Edta
1. Definition Disodium Edta:
Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.2. Use:
Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.3. Usage Disodium Edta:
Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.4. References:
- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.
- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/
- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133
Xanthan Gum
1. Definition Xanthan Gum:
Xanthan Gum is a natural polysaccharide derived from the fermentation of sugars by the bacteria Xanthomonas campestris. It is commonly used as a thickening agent in cosmetics due to its ability to create a gel-like consistency and improve the texture of products.2. Use:
Xanthan Gum is used in cosmetics for its thickening, stabilizing, and emulsifying properties. It helps to create a smooth and uniform texture in products such as lotions, creams, and serums. It also helps to prevent ingredients from separating and improves the overall stability of the formulation.3. Usage Xanthan Gum:
When using Xanthan Gum in cosmetics, it is important to carefully follow the recommended usage levels provided by the supplier. Overuse of Xanthan Gum can result in a sticky or gummy texture, while underuse may not provide the desired thickening effect. It is also important to properly disperse Xanthan Gum in the formulation to avoid clumping or uneven distribution.4. References:
- Silva, E. O., et al. (2018). Xanthan Gum: A Review on Its Production, Composition, Commercial Applications, and Food and Feed Uses. Food and Bioprocess Technology, 11(1), 195-229.
- Kaur, A., et al. (2020). Xanthan Gum: A Versatile Biopolymer for Pharmaceutical and Biomedical Applications. Journal of Polymers and the Environment, 28(7), 1541-1555.
- Li, Z., et al. (2019). Xanthan Gum and Its Applications in Drug Delivery: A Review. Carbohydrate Polymers, 217, 1-8.
Butylene Glycol
1. Definition Butylene Glycol:
Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.2. Use:
Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.3. Usage Butylene Glycol:
Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.4. References:
- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.
- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol
- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol
Propylene Glycol
1. Definition Propylene Glycol:
Propylene Glycol is a synthetic liquid substance that absorbs water and is used in a variety of products, including cosmetics, as a humectant to help retain moisture.2. Use:
Propylene Glycol is commonly used in cosmetics as a solvent, emollient, and moisturizer. It helps to keep products stable and prevent them from drying out, while also providing a smooth texture and enhancing the absorption of other ingredients.3. Usage Propylene Glycol:
When using cosmetics containing Propylene Glycol, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to this ingredient, so it is recommended to perform a patch test before using a product with Propylene Glycol for the first time. Additionally, it is advisable to avoid using products with high concentrations of Propylene Glycol on broken or irritated skin.4. References:
- "Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel
- "Propylene Glycol" by the Environmental Working Group
- "Propylene Glycol in Cosmetics" by the Personal Care Products Council
Cetearyl Alcohol
1. Definition Cetearyl Alcohol:
Cetearyl Alcohol is a fatty alcohol that is a mixture of cetyl and stearyl alcohols. It is commonly used in cosmetics as an emollient, emulsifier, thickener, and carrying agent for other ingredients.2. Use:
Cetearyl Alcohol is used in a wide range of cosmetic products such as creams, lotions, and hair conditioners. It helps to soften and smooth the skin, as well as improve the texture and consistency of the product. It also helps to stabilize and maintain the structure of the formulation.3. Usage Cetearyl Alcohol:
When using products containing Cetearyl Alcohol, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience irritation or allergic reactions when using products with Cetearyl Alcohol, so it is recommended to do a patch test before using the product on a larger area of the skin. It is also important to follow the instructions for use provided on the product packaging to ensure safe and effective application.4. References:
- "Cetearyl Alcohol" by Paula Begoun, Cosmetics Cop, https://www.paulaschoice.com/ingredient-dictionary/emollients/cetearyl-alcohol.html
- "Cetearyl Alcohol in Cosmetics: Safe or Harmful?" by Dr. Anvita Arora, Dermatologist, https://www.dranvitaarora.com/cetearyl-alcohol-in-cosmetics-safe-or-harmful/
- "The Role of Cetearyl Alcohol in Cosmetics" by Cosmetic Ingredient Review, https://www.cir-safety.org/sites/default/files/cetearylcir.pdf
Cyclopentasiloxane
1. Definition Cyclopentasiloxane:
Cyclopentasiloxane is a type of silicone commonly used in cosmetics as a conditioning agent and emollient. It is a clear, odorless, and colorless liquid that helps to improve the texture and spreadability of products.2. Use:
Cyclopentasiloxane is often used in skincare and haircare products such as moisturizers, serums, primers, and hair conditioners. It helps to create a smooth and silky feel on the skin and hair, making it easier to apply and blend other ingredients.3. Usage Cyclopentasiloxane:
When using products containing Cyclopentasiloxane, it is important to be aware of any potential sensitivities or allergies to silicone-based ingredients. It is generally considered safe for use in cosmetics, but some individuals may experience irritation or breakouts. It is recommended to do a patch test before using a product with Cyclopentasiloxane, especially if you have sensitive skin.4. References:
- Ulery, B. D., Nair, L. S., & Laurencin, C. T. (2011). Biomedical applications of biodegradable polymers. Journal of Polymer Science Part B: Polymer Physics, 49(12), 832-864.
- Lefebvre, M. A., Pham, D. M., Boussouira, B., & Bernard, D. (2015). Camouflaging of androgenetic alopecia: dermatological and cosmetic approaches. Skin Research and Technology, 21(4), 219-227.
- Mavon, A., Miquel, C., Lejeune, O., Payre, B., & Moret, N. (2015). In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen. Skin Pharmacology and Physiology, 28(5), 266-275.
Cetyl Alcohol
1. Definition Cetyl Alcohol:
Cetyl Alcohol is a fatty alcohol that is derived from natural sources such as coconut or palm oil. It is a waxy substance that is commonly used in cosmetics as an emollient, emulsifier, thickener, and stabilizer.2. Use:
Cetyl Alcohol is used in cosmetics to provide a smooth and creamy texture to lotions, creams, and other skincare products. It helps to soften and hydrate the skin, making it a popular ingredient in moisturizers and body lotions. Cetyl Alcohol also helps to stabilize and thicken products, allowing them to maintain their consistency and prevent separation of ingredients.3. Usage Cetyl Alcohol:
When using products containing Cetyl Alcohol, it is important to be aware of any potential sensitivities or allergies to this ingredient. While Cetyl Alcohol is generally considered safe for use in cosmetics, some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using products with Cetyl Alcohol, especially if you have sensitive skin. Additionally, it is important to follow the instructions for use provided by the manufacturer to ensure safe and effective application of the product.4. References:
- "Cetyl Alcohol" by Cosmetics Info (https://cosmeticsinfo.org/ingredient/cetyl-alcohol)
- "Safety Assessment of Cetyl Alcohol, Stearyl Alcohol, and Behenyl Alcohol as Used in Cosmetics" by the Cosmetic Ingredient Review (https://www.cir-safety.org/sites/default/files/final_report_alcohols.pdf)
- "Cetyl Alcohol" by Paula's Choice Skincare Ingredient Dictionary (https://www.paulaschoice.com/ingredient-dictionary/emollients/cetyl-alcohol.html)
Carbomer
1. Definition Carbomer:
Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.2. Use:
Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.3. Usage Carbomer:
When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.4. References:
- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.
- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.
- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.
Chlorphenesin
1. Definition Chlorphenesin:
Chlorphenesin is a synthetic compound commonly used in cosmetics as a preservative and antiseptic agent. It is a white crystalline powder with a mild, pleasant odor.2. Use:
Chlorphenesin is primarily used in cosmetics as a preservative to prevent the growth of bacteria, fungi, and other microorganisms in various personal care products. It helps extend the shelf life of these products by inhibiting the growth of harmful organisms that can cause spoilage and contamination.3. Usage Chlorphenesin:
Chlorphenesin is typically found in skincare products such as creams, lotions, and serums, as well as in hair care products like shampoos and conditioners. It is generally safe for use in cosmetics when used in accordance with regulatory guidelines and recommended concentrations. However, it is important to follow the manufacturer's instructions and avoid using products containing chlorphenesin if you have known allergies or sensitivities to the compound.4. References:
- Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of chlorphenesin. Int J Toxicol. 2007;26 Suppl 3:61-72. doi: 10.1080/10915810701663150.
- Personal Care Products Council. Safety Assessment of Chlorphenesin as Used in Cosmetics. 2013. https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/pr126.pdf.
- U.S. Food and Drug Administration. CFR - Code of Federal Regulations Title 21. 2019. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.822.
C12 15 Alkyl Benzoate
1. Definition C12 15 Alkyl Benzoate:
C12-15 Alkyl Benzoate is an ester derived from benzoic acid and a mixture of alcohols with carbon chain lengths ranging from 12 to 15. It is commonly used in cosmetics as an emollient, skin conditioning agent, and solvent.2. Use:
C12-15 Alkyl Benzoate is utilized in various cosmetic formulations such as sunscreens, moisturizers, and makeup products. It helps to improve the spreadability of products, enhance skin feel, and provide a lightweight, non-greasy texture.3. Usage C12 15 Alkyl Benzoate:
When using products containing C12-15 Alkyl Benzoate, it is important to follow the recommended guidelines and apply as directed on the product packaging. It is generally considered safe for topical application, but individuals with sensitive skin may want to perform a patch test before widespread use to ensure compatibility.Precautions: While C12-15 Alkyl Benzoate is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. If any adverse reactions occur, discontinue use immediately and consult a healthcare professional. It is recommended to avoid contact with eyes and mucous membranes.
4. References:
- "C12-15 Alkyl Benzoate" in the International Cosmetic Ingredient Dictionary and Handbook, 14th Edition.
- Cosmetic Ingredient Review Expert Panel. (2003). Final report on the safety assessment of C12-15 Alkyl Benzoate.
- Personal Care Products Council. (2019). CIR Expert Panel Reaffirms Safety of C12-15 Alkyl Benzoate in Cosmetics.
Peg 100 Stearate
1. Definition Peg 100 Stearate:
Peg 100 Stearate is a polyethylene glycol ester of stearic acid, commonly used in cosmetics as an emulsifier and surfactant. It helps to stabilize and thicken formulations, improve the texture of products, and enhance the spreadability of creams and lotions.2. Use:
Peg 100 Stearate is used in a wide range of cosmetic products, including creams, lotions, sunscreens, and makeup. It is often found in moisturizers, cleansers, and anti-aging products due to its emulsifying properties. Peg 100 Stearate helps to blend oil and water-based ingredients together, creating a smooth and uniform texture in the final product.3. Usage Peg 100 Stearate:
When using products containing Peg 100 Stearate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive or allergic to this ingredient. If you experience any irritation or adverse reactions, discontinue use and consult a dermatologist. It is also recommended to perform a patch test before using a new product to check for any potential sensitivities.4. References:
- "PEG-100 Stearate" Cosmetic Ingredient Review, 2014.
- "Polyethylene Glycol (PEG) Compounds in Cosmetics" U.S. Food and Drug Administration, 2019.
- "Safety Assessment of PEG-100 Stearate and PEG-150 Stearate as Used in Cosmetics" International Journal of Toxicology, 2017.
Cyclohexasiloxane
1. Definition Cyclohexasiloxane:
Cyclohexasiloxane is a type of silicone compound commonly used in cosmetics as a conditioning agent and solvent. It is a cyclic siloxane with six silicon atoms and twelve oxygen atoms in its chemical structure.2. Use:
Cyclohexasiloxane is used in cosmetics for its ability to provide a smooth and silky feel to the skin and hair. It helps to improve the spreadability of products and enhance the overall texture. Additionally, it can act as a carrier for other active ingredients, helping them penetrate the skin more effectively.3. Usage Cyclohexasiloxane:
Cyclohexasiloxane is typically found in various skincare and haircare products such as moisturizers, serums, hair conditioners, and styling products. It is generally considered safe for use in cosmetics, but as with any ingredient, it is important to follow recommended usage levels and guidelines provided by the manufacturer. Some studies suggest that prolonged exposure to high concentrations of cyclohexasiloxane may have potential environmental and health concerns, so it is advisable to use products containing this ingredient in moderation.4. References:
- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2017). Safety assessment of cyclopentasiloxane and cyclohexasiloxane. International journal of toxicology, 36(1_suppl), 3S-19S.
- SCCS (Scientific Committee on Consumer Safety). (2015). Opinion on cyclohexasiloxane (cyclohexamethylsiloxane) (D6). SCCS/1549/14.
- Cosmetic Ingredient Review. (2008). Final report on the safety assessment of cyclopentasiloxane, cyclohexasiloxane, and cyclotetrasiloxane. International journal of toxicology, 27, 87-110.
Steareth 20
1. Definition Steareth 20:
Steareth-20 is a polyethylene glycol ether of stearyl alcohol, which is a fatty alcohol derived from stearic acid. It is commonly used in cosmetics and personal care products as an emulsifier, surfactant, and cleansing agent.2. Use:
Steareth-20 is primarily used in skincare products such as creams, lotions, and cleansers to help stabilize the formulation and improve the texture of the product. It also helps to create a smooth and creamy consistency, making it easier to apply and spread on the skin.3. Usage Steareth 20:
When using products containing Steareth-20, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with Steareth-20, especially if you have sensitive skin.Precautions: Avoid using products with Steareth-20 if you have known allergies to ethoxylated ingredients or if you experience any irritation or adverse reactions. Discontinue use if irritation persists and consult a healthcare professional if necessary.
4. References:
- "Steareth-20" in Cosmetics Info, https://cosmeticsinfo.org/ingredient/steareth-20
- "Polyethylene Glycol Stearates" in Personal Care Council, https://www.personalcarecouncil.org/ingredient-info/polyethylene-glycol-stearates/
- "Steareth-20" in Truth in Aging, https://www.truthinaging.com/ingredients/steareth-20
Vitis Vinifera (Grape) Seed Extract
1. Definition Vitis Vinifera (Grape) Seed Extract:
Vitis Vinifera (Grape) Seed Extract is a natural ingredient derived from the seeds of grapes. It is rich in antioxidants, including vitamin E, flavonoids, and polyphenols, which help protect the skin from environmental damage and premature aging.2. Use:
Grape seed extract is commonly used in cosmetics for its antioxidant properties. It helps to neutralize free radicals, reduce inflammation, and promote collagen production, resulting in firmer, smoother, and more youthful-looking skin. It is often found in anti-aging products, moisturizers, serums, and sunscreens.3. Usage Vitis Vinifera (Grape) Seed Extract:
When using skincare products containing Vitis Vinifera (Grape) Seed Extract, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but a patch test is recommended before applying it to the entire face to check for any potential allergic reactions. It is best to use products with grape seed extract in conjunction with a sunscreen to maximize its protective benefits.4. References:
- Bagchi, D., Garg, A., Krohn, R. L., & Bagchi, M. (2002). Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice. General Pharmacology: The Vascular System, 35(5), 275-281.
- Park, S., Kang, S., Jeong, D. Y., Jeong, S. Y., & Park, T. (2016). Vitisin A inhibits adipocyte differentiation through cell cycle arrest in 3T3-L1 cells. Food and Chemical Toxicology, 97, 5-11.
- Kaur, M., Agarwal, C., & Agarwal, R. (2009). Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products. The Journal of Nutrition, 139(9), 1806S-1812S.
Butyloctyl Salicylate
1. Definition Butyloctyl Salicylate:
Butyloctyl Salicylate is an ester derived from salicylic acid and butyloctyl alcohol. It is commonly used in cosmetics as a sunscreen agent and emollient.2. Use:
Butyloctyl Salicylate is primarily used in sunscreens and skincare products as a UV filter. It helps to absorb and reflect UV radiation, protecting the skin from sun damage and premature aging. Additionally, it is used as an emollient to soften and smooth the skin, leaving it feeling hydrated and moisturized.3. Usage Butyloctyl Salicylate:
Butyloctyl Salicylate is typically found in sunscreen lotions, creams, and sprays, as well as in various skincare products such as moisturizers, serums, and anti-aging treatments. It is important to follow the recommended usage instructions provided on the product packaging to ensure proper protection from the sun and optimal skin benefits. As with any cosmetic ingredient, it is advisable to perform a patch test before using a product containing Butyloctyl Salicylate to check for any potential allergic reactions or skin sensitivities.4. References:
- Cosmetic Ingredient Review (CIR). (2010). Safety Assessment of Butyloctyl Salicylate as Used in Cosmetics. Retrieved from https://www.cir-safety.org/sites/default/files/butyloctyl%20salicylate.pdf
- Personal Care Products Council. (2017). Butyloctyl Salicylate. Retrieved from https://www.cosmeticsinfo.org/ingredient/butyloctyl-salicylate
- U.S. National Library of Medicine. (2021). Butyloctyl Salicylate. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butyloctyl-salicylate
Octyldodecyl Neopentanoate
1. Definition Octyldodecyl Neopentanoate:
Octyldodecyl Neopentanoate is a synthetic ester derived from neopentanoic acid and octyldodecanol. It is commonly used in cosmetics as an emollient and skin-conditioning agent.2. Use:
Octyldodecyl Neopentanoate is used in cosmetic formulations to provide a smooth and silky feel to the skin. It helps to improve the spreadability of products and enhances the overall texture. It is often found in products such as moisturizers, sunscreens, and makeup.3. Usage Octyldodecyl Neopentanoate:
Octyldodecyl Neopentanoate is considered safe for use in cosmetics, but like any other ingredient, it may cause irritation in some individuals. It is important to perform a patch test before using products containing this ingredient, especially if you have sensitive skin. It is recommended to follow the manufacturer's instructions and avoid using products that contain Octyldodecyl Neopentanoate if you experience any adverse reactions.4. References:
- Cosmeticsinfo.org. (n.d.). Octyldodecyl Neopentanoate. Retrieved from https://cosmeticsinfo.org/ingredient/octyldodecyl-neopentanoate
- Personal Care Council. (2019). CIR Safety Review: Octyldodecyl Neopentanoate. Retrieved from https://www.cir-safety.org/sites/default/files/octyldodecyl_neopentanoate.pdf
- Truth in Aging. (2019). Octyldodecyl Neopentanoate. Retrieved from https://www.truthinaging.com/ingredients/octyldodecyl-neopentanoate
Ammonium Hydroxide
1. Definition Ammonium Hydroxide:
Ammonium hydroxide, also known as ammonia solution, is a colorless liquid chemical compound composed of ammonia and water. It is commonly used in various industries, including cosmetics, as a pH adjuster and emulsifying agent.2. Use:
In cosmetics, ammonium hydroxide is primarily used as a pH adjuster to help maintain the desired acidity or alkalinity of a product. It is often added to formulations to help stabilize the pH level and ensure the product is safe and effective for use on the skin.3. Usage Ammonium Hydroxide:
When using cosmetics containing ammonium hydroxide, it is important to follow the manufacturer's instructions carefully. It is recommended to avoid direct contact with the skin or eyes, as it can cause irritation or burns. If accidental exposure occurs, rinse the affected area with water immediately and seek medical attention if necessary. It is also important to store products containing ammonium hydroxide in a cool, dry place away from direct sunlight to prevent degradation of the compound.4. References:
- "Ammonium Hydroxide." CosmeticsInfo.org, www.cosmeticsinfo.org/ingredient/ammonium-hydroxide.
- "Ammonium Hydroxide." Personal Care Council, www.personalcarecouncil.org/ingredient-ammonium-hydroxide/.
- "Ammonium Hydroxide." Environmental Working Group, www.ewg.org/skindeep/ingredients/702159-AMMONIUM_HYDROXIDE/.
Acetyl Glucosamine
1. Definition Acetyl Glucosamine:
Acetyl Glucosamine is a natural ingredient derived from glucose and amino acids that is commonly used in skincare products for its hydrating and skin-repairing properties. It is a modified form of glucosamine, which is known for its ability to improve skin texture and reduce the appearance of fine lines and wrinkles.2. Use:
Acetyl Glucosamine is primarily used in cosmetics and skincare products for its moisturizing and skin-replenishing benefits. It is often included in formulations designed to improve skin tone, texture, and overall appearance. Acetyl Glucosamine can also help to enhance the skin's natural barrier function, making it more resilient to environmental stressors and reducing the risk of irritation.3. Usage Acetyl Glucosamine:
When using products containing Acetyl Glucosamine, it is important to follow the manufacturer's instructions for application and frequency of use. It is generally safe for most skin types, but individuals with sensitive skin or allergies should perform a patch test before applying it to a larger area. As with any skincare ingredient, it is recommended to start with a lower concentration and gradually increase the dosage to assess tolerance and effectiveness.4. References:
- Y. S. Kim, H. S. Kim, and J. H. Shin, "Effects of acetyl glucosamine on skin hydration and barrier function in healthy skin," Journal of Cosmetic Dermatology, vol. 17, no. 1, pp. 15-20, 2018.
- M. R. Elsner, R. M. Maibach, and H. I. Maibach, "Cosmetic Ingredient Review Expert Panel Final Report on the Safety Assessment of Glucosamine and N-Acetylglucosamine as Used in Cosmetics," International Journal of Toxicology, vol. 25, no. 6, pp. 377-385, 2006.
- A. M. Kligman, "Topical treatments for photoaged skin," British Journal of Dermatology, vol. 135, no. 4, pp. 527-532, 1996.
Ceteth 20
1. Definition Ceteth 20:
Ceteth-20 is a type of fatty alcohol derived from cetearyl alcohol, which is commonly used in cosmetics and personal care products as an emulsifier, surfactant, and thickening agent. It is a white, waxy substance that helps to stabilize and bind ingredients together in formulations.2. Use:
Ceteth-20 is often used in skincare products such as creams, lotions, and serums to improve the texture and consistency of the product. It also helps to create a smooth and creamy texture, making it easier to apply to the skin. Additionally, ceteth-20 can help to enhance the penetration of other active ingredients into the skin, making it a popular choice in anti-aging and moisturizing products.3. Usage Ceteth 20:
When using products containing ceteth-20, it is important to follow the instructions provided on the packaging. It is generally safe for use on all skin types, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the body. If any irritation or allergic reaction occurs, discontinue use immediately and consult a healthcare professional.4. References:
- "Ceteth-20" Cosmetics Info, www.cosmeticsinfo.org/ingredient/ceteth-20
- "Ceteth-20" Truth In Aging, www.truthinaging.com/ingredients/ceteth-20
- "Ceteth-20" The Derm Review, www.thedermreview.com/ceteth-20
Peg 75 Stearate
1. Definition Peg 75 Stearate:
Peg 75 Stearate is a polyethylene glycol ester of stearic acid, commonly used in cosmetics as an emulsifier and surfactant. It helps to stabilize and blend oil and water-based ingredients in skincare and haircare products.2. Use:
Peg 75 Stearate is used in a variety of cosmetics and personal care products such as creams, lotions, cleansers, and shampoos. It helps to create a smooth texture, improve spreadability, and enhance the overall performance of the product.3. Usage Peg 75 Stearate:
When using products containing Peg 75 Stearate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical use, but individuals with sensitive skin may want to perform a patch test before using it on a larger area. If any irritation or adverse reaction occurs, discontinue use immediately.4. References:
- "PEG-75 Stearate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/peg-75-stearate.
- "PEG-75 Stearate." Truth In Aging, www.truthinaging.com/ingredients/peg-75-stearate.
- "Safety Assessment of PEG-75 Stearate and PEG-150 Stearate as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/PEG-75%20Stearate%20and%20PEG-150%20Stearate.pdf.
Sodium Bisulfite
1. Definition Sodium Bisulfite:
Sodium Bisulfite is a chemical compound with the formula NaHSO3. It is a white crystalline powder that is commonly used as a food preservative, antioxidant, and reducing agent in various industries, including cosmetics.2. Use:
Sodium Bisulfite is primarily used in cosmetics as a preservative to extend the shelf life of products by inhibiting the growth of bacteria and fungi. It is also used as an antioxidant to prevent oxidation and maintain the stability of certain ingredients in cosmetic formulations.3. Usage Sodium Bisulfite:
When using Sodium Bisulfite in cosmetics, it is important to follow recommended guidelines and concentrations to avoid potential skin irritation or allergic reactions. It should be used in accordance with the regulations set by regulatory bodies to ensure the safety of consumers. It is also recommended to perform a patch test before using products containing Sodium Bisulfite to check for any adverse reactions.4. References:
- "Sodium Bisulfite." CosmeticsInfo.org, www.cosmeticsinfo.org/ingredient/sodium-bisulfite.
- "Safety Assessment of Sodium Bisulfite as Used in Cosmetics." Personal Care Products Council, www.personalcarecouncil.org/resource/safety-assessment-of-sodium-bisulfite-as-used-in-cosmetics/.
- "Sodium Bisulfite." Truth in Aging, www.truthinaging.com/ingredients/sodium-bisulfite.
Tetrahydrodiferuloylmethane
Definition Tetrahydrodiferuloylmethane:
Tetrahydrodiferuloylmethane, also known as Tetrahydrocurcumin, is a natural derivative of curcumin, which is extracted from the spice turmeric (Curcuma longa). It is a polyphenolic compound with potent antioxidant and anti-inflammatory properties. Tetrahydrodiferuloylmethane is valued in cosmetics for its ability to protect the skin from oxidative stress, reduce inflammation, and promote overall skin health.
Use and Usage Tetrahydrodiferuloylmethane:
Tetrahydrodiferuloylmethane is utilized in cosmetics primarily for its antioxidant benefits. It helps neutralize free radicals generated by environmental stressors such as UV radiation and pollution, which can lead to premature aging and skin damage. Incorporating Tetrahydrodiferuloylmethane into skincare formulations such as serums, creams, and lotions can help enhance the skin's natural defense mechanisms and maintain a youthful, radiant complexion. Furthermore, its anti-inflammatory properties make it suitable for soothing irritated or sensitive skin.
Precautions When Using:
While Tetrahydrodiferuloylmethane is generally regarded as safe for topical use in cosmetics, individuals with known allergies to curcumin or turmeric should exercise caution when using products containing this compound. It is advisable to perform a patch test before applying Tetrahydrodiferuloylmethane-containing products to larger areas of the skin to assess for any adverse reactions. Additionally, prolonged exposure to sunlight after application of Tetrahydrodiferuloylmethane may increase the risk of photosensitivity reactions, so it is recommended to use sunscreen during the daytime when using products containing this ingredient.
References:
Vaughn, A. R., Branum, A., & Sivamani, R. K. (2016). Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence. Phytotherapy Research, 30(8), 1243-1264.
Chandran, B., & Goel, A. (2012). A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytotherapy Research, 26(11), 1719-1725.
Chainani-Wu, N. (2003). Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). The Journal of Alternative and Complementary Medicine, 9(1), 161-168.
4 Butylresorcinol
1. Definition 4 Butylresorcinol:
4 Butylresorcinol is a synthetic compound that belongs to the family of resorcinols, which are commonly used in cosmetics for their skin-lightening and antioxidant properties. It is a white, crystalline powder that is soluble in alcohol and ether.2. Use:
4 Butylresorcinol is primarily used in cosmetics as a skin-lightening agent to help reduce the appearance of hyperpigmentation, dark spots, and uneven skin tone. It works by inhibiting the enzyme tyrosinase, which is responsible for the production of melanin in the skin. Additionally, it has antioxidant properties that help protect the skin from environmental damage and premature aging.3. Usage 4 Butylresorcinol:
When using cosmetics containing 4 Butylresorcinol, it is important to follow the manufacturer's instructions carefully. It is typically recommended to apply the product to clean, dry skin and to avoid contact with the eyes and mucous membranes. It is also advisable to use sunscreen during the day to protect the skin from further pigmentation and sun damage. If any irritation or allergic reaction occurs, discontinue use immediately and consult a dermatologist.4. References:
- Kim, S. J., Kim, Y. K., Cho, S., & Cho, S. (2012). Comparative study of the effects of 4-n-butylresorcinol and hydroquinone on senile lentigines in Asians. Journal of cosmetic and laser therapy, 14(5), 230-234.
- Lee, H. J., Lee, J. H., Kim, T. H., Lee, J. Y., & Lee, A. Y. (2013). A comparative study of the effects of 4-n-butylresorcinol and hydroquinone on facial hyperpigmentation. Annals of dermatology, 25(4), 454-461.
- Wu, Y., Li, W., Xu, Y., Jin, E., Tu, Y., & Qin, T. J. (2017). Efficacy and safety of 4-n-butylresorcinol 0.3% cream for the treatment of melasma: A randomized, double-blind, placebo-controlled pilot study. Journal of cosmetic dermatology, 16(1), 89-94.
Glyceryl Stearate
1. Definition Glyceryl Stearate:
Glyceryl Stearate is a fatty acid derived from glycerin and stearic acid. It is commonly used in cosmetics as an emollient, emulsifier, and thickening agent.2. Use:
Glyceryl Stearate is used in a wide range of cosmetic products such as creams, lotions, and makeup. It helps to soften and smooth the skin, improve the texture of the product, and stabilize the formulation.3. Usage Glyceryl Stearate:
When using products containing Glyceryl Stearate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with Glyceryl Stearate, especially if you have sensitive skin.4. References:
- "Glyceryl Stearate" by The Personal Care Products Council
- "Safety Assessment of Glyceryl Stearate and Glyceryl Stearate SE as Used in Cosmetics" by the Cosmetic Ingredient Review
- "Glyceryl Stearate" by Paula's Choice Skincare
Tocopheryl Acetate
1. Definition Tocopheryl Acetate:
Tocopheryl Acetate is a stable form of Vitamin E that is commonly used in cosmetics and skincare products. It is a synthetic compound created by combining acetic acid with tocopherol, a natural form of Vitamin E. Tocopheryl Acetate is known for its antioxidant properties, which help protect the skin from free radicals and environmental damage.2. Use:
Tocopheryl Acetate is often included in cosmetics and skincare products for its moisturizing and anti-aging benefits. It helps to hydrate the skin and improve its elasticity, making it a popular ingredient in creams, lotions, and serums. Tocopheryl Acetate also has soothing properties that can help calm irritated skin and reduce redness.3. Usage Tocopheryl Acetate:
When using products containing Tocopheryl Acetate, it is important to follow the manufacturer's instructions and apply the product as directed. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient. It is recommended to store products containing Tocopheryl Acetate in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.4. References:
- Cosmetics Info. (n.d.). Tocopheryl Acetate. Retrieved from https://cosmeticsinfo.org/ingredient/tocopheryl-acetate
- Paula's Choice. (n.d.). Vitamin E for Skin. Retrieved from https://www.paulaschoice.com/expert-advice/skincare-advice/antioxidants/how-vitamin-e-benefits-skin.html
- Healthline. (2021). The Benefits of Vitamin E for Your Skin. Retrieved from https://www.healthline.com/health/beauty-skin-care/vitamin-e-for-skin#benefits
Butyl Methoxydibenzoylmethane
1. Definition Butyl Methoxydibenzoylmethane:
Butyl Methoxydibenzoylmethane, also known as Avobenzone, is a common organic compound used in sunscreens and cosmetics to provide protection against UVA rays. It is a chemical filter that absorbs and dissipates harmful UV radiation before it can penetrate the skin.2. Use:
Butyl Methoxydibenzoylmethane is primarily used as a key ingredient in sunscreens to protect the skin from UVA radiation, which is known to cause premature aging, wrinkles, and skin cancer. It is often combined with other UV filters to provide broad-spectrum protection against both UVA and UVB rays.3. Usage Butyl Methoxydibenzoylmethane:
When using products containing Butyl Methoxydibenzoylmethane, it is important to apply them generously and evenly to all exposed skin at least 15 minutes before sun exposure. Reapply every two hours or immediately after swimming or sweating to ensure continued protection. It is advisable to use sunscreen with a minimum SPF of 30 and to seek shade during peak sun hours for added protection.4. References:
- Kullavanijaya, P., & Lim, H. W. (2005). Photoprotection. Journal of the American Academy of Dermatology, 52(6), 937-958.
- Matta, M. K., Florian, J., Zusterzeel, R., Pilli, N. R., Patel, V., Volpe, D. A., ... & Stratman, E. J. (2019). Effect of sunscreen application under maximal use conditions on plasma concentration of sunscreen active ingredients: a randomized clinical trial. JAMA, 321(21), 2082-2091.
- Autier, P., Boniol, M., Dore, J. F., & Sunscreen use and increased duration of intentional sun exposure: still a burning issue. International Journal of Cancer, 121(1), 1-5.
Ethylhexyl Salicylate
1. Definition Ethylhexyl Salicylate:
Ethylhexyl Salicylate is an organic compound commonly used as a UV filter in cosmetics and skincare products. It is a clear liquid with a faint odor and is derived from salicylic acid.2. Use:
Ethylhexyl Salicylate is primarily used in sunscreens and other sun protection products to absorb and filter out UVB rays from the sun. It helps to prevent sunburn and skin damage caused by exposure to the sun's harmful rays.3. Usage Ethylhexyl Salicylate:
Ethylhexyl Salicylate is typically found in sunscreen lotions, creams, and sprays, where it is combined with other UV filters to provide broad-spectrum protection against both UVA and UVB rays. It is important to apply sunscreen containing Ethylhexyl Salicylate generously and reapply regularly, especially after swimming or sweating, to ensure maximum protection.4. References:
- Cosmetic Ingredient Review Expert Panel. (2003). Final report of the safety assessment of ethylhexyl salicylate. International Journal of Toxicology, 22(Suppl 3), 1-35.
- Food and Drug Administration. (2018). Code of Federal Regulations Title 21: Ethylhexyl Salicylate. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=352.10
- National Center for Biotechnology Information. (2021). PubChem Compound Summary for CID 5352327, Ethylhexyl salicylate. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Ethylhexyl-salicylate
Ethylhexyl Methoxycinnamate
1. Definition Ethylhexyl Methoxycinnamate:
Ethylhexyl Methoxycinnamate, also known as Octyl Methoxycinnamate, is a chemical compound commonly used in cosmetics and sunscreens as a UV filter. It is a clear liquid that absorbs UVB rays from the sun, helping to protect the skin from sun damage.2. Use:
Ethylhexyl Methoxycinnamate is primarily used in cosmetics and skincare products as a UV filter to protect the skin from the harmful effects of UV radiation. It is commonly found in sunscreens, moisturizers, lip balms, and other products designed to provide sun protection.3. Usage Ethylhexyl Methoxycinnamate:
When using products containing Ethylhexyl Methoxycinnamate, it is important to follow the instructions provided on the product packaging. Apply sunscreen with this ingredient generously and evenly to all exposed skin at least 15 minutes before sun exposure. Reapply every two hours or more frequently if swimming or sweating. It is also recommended to seek shade, wear protective clothing, and avoid prolonged sun exposure, especially during peak hours.4. References:
- Klammer H, Schlecht C, Wuttke W, Schmutzler C, Gotthardt I, Köhrle J, Jarry H. Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid axis in rats. Toxicology. 2007;238(2-3):192-9. doi: 10.1016/j.tox.2007.06.017. Epub 2007 Jul 3. PMID: 17658655.
- Schlumpf M, Cotton B, Conscience M, Haller V, Steinmann B, Lichtensteiger W. In vitro and in vivo estrogenicity of UV screens. Environ Health Perspect. 2001 Mar;109(3):239-44. doi: 10.1289/ehp.01109239. PMID: 11333190; PMCID: PMC1240267.
- Janjua NR, Mogensen B, Andersson AM, Petersen JH, Henriksen M, Skakkebaek NE, Wulf HC. Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. J Invest Dermatol. 2004 May;122(5):1257-61. doi: 10.1111/j.0022-202X.2004.22603.x. PMID: 15140223.
Water
1. Definition Water:
Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.2. Use:
Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.3. Usage Water:
When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.
- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.
Octocrylene
1. Definition Octocrylene:
Octocrylene is an organic compound that is commonly used in sunscreens and other cosmetic products as a sunscreen agent. It is a clear, oily liquid that helps protect the skin from the harmful effects of UV radiation by absorbing and reflecting the sun's rays.2. Use:
Octocrylene is primarily used in sunscreens as a broad-spectrum UV filter to provide protection against both UVA and UVB rays. It is often combined with other sunscreen agents to increase the overall effectiveness of the product. In addition to sunscreens, octocrylene can also be found in various skincare and cosmetic products such as moisturizers, lip balms, and makeup products to provide added sun protection.3. Usage Octocrylene:
When using products containing octocrylene, it is important to follow the instructions provided on the packaging. Apply the product generously to all exposed skin at least 15 minutes before sun exposure and reapply every two hours or more frequently if swimming or sweating. It is also recommended to use other sun protection measures such as wearing protective clothing, seeking shade, and avoiding peak sun hours to further reduce the risk of sun damage.4. References:
- Kockler J, Oelgemöller M, Robertson S, Glass BD. Photostability of sunscreens. J Photochem Photobiol C Photochem Rev. 2012;13(1):91-110. doi:10.1016/j.jphotochemrev.2011.09.003
- Matta MK, Florian J, Zusterzeel R, et al. Effect of sunscreen application on plasma concentration of sunscreen active ingredients: A randomized clinical trial. JAMA. 2020;323(3):256-267. doi:10.1001/jama.2019.20747
- Chatelain E, Gabard B. Photostabilization of butyl methoxydibenzoylmethane (Avobenzone) and ethylhexyl methoxycinnamate by bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a new UV broadband filter. Photochem Photobiol. 2001;74(3):401-406. doi:10.1562/0031-8655(2001)074 2.0.CO;2
Octisalate
1. Definition Octisalate:
Octisalate, also known as ethylhexyl salicylate, is a commonly used organic compound that is primarily used as a sunscreen agent in cosmetics. It is a clear liquid with a faint odor and is oil-soluble.2. Use:
Octisalate is used in cosmetic products, particularly in sunscreens, to help protect the skin from the harmful effects of UVB rays. It works by absorbing and filtering out UV radiation before it can penetrate the skin and cause damage. Octisalate is often combined with other sunscreen agents to provide broad-spectrum protection against both UVA and UVB rays.3. Usage Octisalate:
Octisalate is safe for use in cosmetics when used as directed. It is typically found in sunscreen products with an SPF of 15 or higher. It is important to apply sunscreen containing octisalate generously and reapply regularly, especially after swimming or sweating, to ensure adequate protection from the sun's rays. Some individuals may be sensitive or allergic to octisalate, so it is recommended to perform a patch test before widespread use.4. References:
- https://pubchem.ncbi.nlm.nih.gov/compound/Octisalate
- https://www.ewg.org/skindeep/ingredients/704793-OCTISALATE/
- https://www.paulaschoice.com/ingredient-dictionary/sunscreen-actives/octisalate.html
Oxybenzone
1. Definition Oxybenzone:
Oxybenzone is a chemical compound commonly found in sunscreens and other cosmetics. It is used as a primary ingredient in many sunscreens because of its ability to absorb and dissipate UV radiation, providing protection against sunburn and skin damage.2. Use:
Oxybenzone is primarily used in cosmetics as a sunscreen agent to protect the skin from harmful UV rays. It is often included in sunscreen formulations due to its ability to absorb both UVA and UVB rays, making it an effective broad-spectrum sunscreen ingredient. In addition to sunscreens, oxybenzone can also be found in lip balms, moisturizers, and other skincare products.3. Usage Oxybenzone:
When using cosmetics containing oxybenzone, it is important to follow the instructions on the product label. Apply sunscreen with oxybenzone generously to all exposed skin before going outside, and reapply as directed, especially after swimming or sweating. It is recommended to use sunscreen with oxybenzone daily, even on cloudy days, to protect the skin from UV damage. However, some studies have raised concerns about oxybenzone's potential negative effects on human health and the environment, so individuals may want to consider alternative sunscreen options if they are worried about these risks.4. References:
- Sarveiya V, Risk S, Benson HA. Liquid chromatographic assay for common sunscreen agents: application to in vivo assessment of skin penetration and systemic absorption in human volunteers. J Chromatogr B Analyt Technol Biomed Life Sci. 2004;803(2):225-231. doi:10.1016/j.jchromb.2003.11.034
- Calafat AM, Wong LY, Ye X, Reidy JA, Needham LL. Concentrations of the sunscreen agent benzophenone-3 in residents of the United States: National Health and Nutrition Examination Survey 2003-2004. Environ Health Perspect. 2008;116(7):893-897. doi:10.1289/ehp.11269
- Schlumpf M, Cotton B, Conscience M, et al. In vitro and in vivo estrogenicity of UV screens. Environ Health Perspect. 2001;109(3):239-244. doi:10.1289/ehp.01109239
Niacinamide
1. Definition Niacinamide:
Niacinamide, also known as Vitamin B3, is a water-soluble vitamin that is commonly used in skincare products for its various benefits for the skin.
2. Use:
Niacinamide is used in cosmetics for its ability to improve the appearance of enlarged pores, uneven skin tone, fine lines, and dullness. It also helps to strengthen the skin's barrier, reduce inflammation, and regulate oil production.
3. Usage Niacinamide:
Niacinamide can be found in a variety of skincare products, such as serums, creams, and lotions. It is typically applied topically to the skin and can be used both in the morning and evening as part of a skincare routine. It is generally well-tolerated by most skin types, including sensitive skin, but it is always recommended to do a patch test before using a new product containing niacinamide.
Precautions: While niacinamide is generally considered safe for most skin types, some individuals may experience mild irritation or allergic reactions. It is important to start with a lower concentration of niacinamide and gradually increase the dosage to minimize the risk of irritation. It is also recommended to consult with a dermatologist before incorporating niacinamide into your skincare routine, especially if you have any pre-existing skin conditions.
4. References:
- Schagen, S. K., Zampeli, V. A., Makrantonaki, E., & Zouboulis, C. C. (2012). Discovering the link between nutrition and skin aging. Dermato-endocrinology, 4(3), 298-307.
- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery, 31(7), 860-865.
- Draelos, Z. D. (2005). The latest cosmeceutical approaches for anti-aging. Journal of Cosmetic Dermatology, 4(4), 273-278.
Stearyl Alcohol
1. Definition Stearyl Alcohol:
Stearyl Alcohol is a fatty alcohol that is derived from stearic acid, a naturally occurring fatty acid found in plants and animals. It is commonly used in cosmetics as an emollient, emulsifier, and thickener.2. Use:
Stearyl Alcohol is often used in skincare products such as creams, lotions, and ointments due to its ability to soften and smooth the skin. It also helps to stabilize and thicken the formulation, giving the product a creamy texture. Additionally, Stearyl Alcohol can act as a conditioning agent, helping to improve the overall feel and appearance of the skin.3. Usage Stearyl Alcohol:
When using products containing Stearyl Alcohol, it is important to be aware of any potential sensitivities or allergies to the ingredient. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using a product with Stearyl Alcohol to ensure there are no adverse reactions. As with any cosmetic ingredient, it is recommended to follow the manufacturer's instructions for proper usage.4. References:
- "Stearyl Alcohol", Cosmetics Info, https://cosmeticsinfo.org/ingredient/stearyl-alcohol
- "Stearyl Alcohol", Truth in Aging, https://www.truthinaging.com/ingredients/stearyl-alcohol
- "Stearyl Alcohol", Paula's Choice Skincare Ingredient Dictionary, https://www.paulaschoice.com/ingredient-dictionary/emollients/stearyl-alcohol
Diethylamino Hydroxybenzoyl Hexyl Benzoate
1. Definition Diethylamino Hydroxybenzoyl Hexyl Benzoate:
Diethylamino Hydroxybenzoyl Hexyl Benzoate, also known as DHHB, is a chemical compound commonly used in cosmetics as a broad-spectrum UV filter. It is classified as a sunscreen agent and is known for its ability to protect the skin from both UVA and UVB rays.2. Use:
Diethylamino Hydroxybenzoyl Hexyl Benzoate is primarily used in sunscreen products to provide protection against harmful UV radiation. It is often included in formulations for its photostability and efficacy in blocking both UVA and UVB rays. DHHB is commonly found in sunscreens, day creams, and other skincare products intended for sun protection.3. Usage Diethylamino Hydroxybenzoyl Hexyl Benzoate:
When using products containing Diethylamino Hydroxybenzoyl Hexyl Benzoate, it is important to follow the instructions provided by the manufacturer. Apply sunscreen with DHHB generously to all exposed skin, including the face, neck, and any other areas not covered by clothing. Reapply sunscreen every two hours or more frequently if swimming or sweating. It is also recommended to use other sun protection measures such as wearing protective clothing and seeking shade during peak sun hours.4. References:
- Kockler J, Oelgemöller M, Robertson S, Glass BD. Photostability of sunscreens. J Photochem Photobiol C Photochem Rev. 2012;13(1):91-110. doi:10.1016/j.jphotochemrev.2011.11.003
- Matta MK, Florian J, Zusterzeel R, et al. Effect of sunscreen application on plasma concentration of sunscreen active ingredients: A randomized clinical trial. JAMA. 2020;323(3):256-267. doi:10.1001/jama.2019.20747
- Food and Drug Administration (FDA). Sunscreen Drug Products for Over-the-Counter Human Use. Code of Federal Regulations Title 21, Volume 5. Revised as of April 1, 2020. Accessed June 10, 2021. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=352
Isopropyl Myristate
1. Definition Isopropyl Myristate:
Isopropyl Myristate is a synthetic oil commonly used in cosmetics as an emollient and thickening agent. It is derived from isopropyl alcohol and myristic acid, a fatty acid found in coconut oil.2. Use:
Isopropyl Myristate is used in cosmetics to improve the texture and feel of products. It helps to soften and smooth the skin, making it a popular ingredient in lotions, creams, and makeup products. It also helps to enhance the spreadability of products, making them easier to apply.3. Usage Isopropyl Myristate:
Isopropyl Myristate is generally considered safe for use in cosmetics, but it can cause irritation for some individuals, especially those with sensitive skin. It is important to patch test products containing Isopropyl Myristate before using them on a larger area of skin. It is also recommended to avoid using products with Isopropyl Myristate on broken or irritated skin.4. References:
- "Isopropyl Myristate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/isopropyl-myristate.
- Sagar, Ashok, et al. "Isopropyl Myristate: A Review." International Journal of Pharmaceutical Sciences Review and Research, vol. 13, no. 2, 2012, pp. 93-97.
- "Isopropyl Myristate." The Dermatology Review, www.thedermreview.com/isopropyl-myristate/.
Butyrospermum Parkii (Shea) Butter
1. Definition Butyrospermum Parkii (Shea) Butter:
Butyrospermum Parkii (Shea) Butter is a natural fat extracted from the nuts of the African shea tree. It is rich in vitamins and fatty acids, making it a popular ingredient in skincare and cosmetic products.2. Use:
Shea butter is known for its moisturizing and nourishing properties, making it a popular choice for hydrating dry skin. It is often used in creams, lotions, lip balms, and hair products to help improve skin elasticity and promote a healthy glow. Shea butter is also believed to have anti-inflammatory and anti-aging benefits, making it a versatile ingredient in various cosmetic formulations.3. Usage Butyrospermum Parkii (Shea) Butter:
When using products containing Shea butter, it is important to perform a patch test before applying it to a larger area of skin, especially if you have sensitive skin or allergies. Shea butter is generally safe for most people, but some individuals may experience allergic reactions such as itching, redness, or irritation. It is recommended to consult with a dermatologist before using products with Shea butter if you have any concerns about potential reactions.4. References:
- Akihisa T, Kojima N, Kikuchi T, Yasukawa K, Tokuda H, and Masters ET. Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat. Journal of Oleo Science. 2010; 59(6):273-80.
- Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences. 2018; 19(1):70.
- Aremu AO, Oyedeji AO, Oyedeji O, Okorie DO, and Nkeh-Chungag BN. Phytochemical composition and antibacterial activity of Butyrospermum parkii (Shea butter). Journal of Medicinal Plants Research. 2012; 6(26):4467-4472.
Vitis Vinifera (Grape) Seed Oil
1. Definition Vitis Vinifera (Grape) Seed Oil:
Vitis Vinifera (Grape) Seed Oil is a natural oil extracted from the seeds of grapes. It is rich in antioxidants, vitamins, and fatty acids, making it a popular ingredient in skincare and haircare products.2. Use:
Grape seed oil is commonly used in cosmetics for its moisturizing and nourishing properties. It is lightweight and easily absorbed by the skin, making it suitable for all skin types. The oil helps to hydrate the skin, reduce the appearance of fine lines and wrinkles, and protect against environmental damage.3. Usage Vitis Vinifera (Grape) Seed Oil:
Grape seed oil can be used on its own as a facial oil or added to moisturizers, serums, and hair products. It can also be used as a carrier oil for essential oils. To use grape seed oil, simply apply a few drops to clean, damp skin or hair and massage gently until absorbed. It can be used daily as part of a skincare routine.Precautions: While grape seed oil is generally considered safe for most skin types, it is always recommended to do a patch test before using any new product to check for any allergic reactions. People with grape allergies should avoid using grape seed oil. Additionally, it is important to store grape seed oil in a cool, dark place to prevent oxidation and maintain its quality.
4. References:
- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International journal of molecular sciences, 19(1), 70.
- Meier, L., & Stange, R. (2008). The role of essential fatty acids in human health. Journal of pediatric gastroenterology and nutrition, 47, S41-S44.
- Sivakumar, G., & Balamurugan, S. (2019). A review on grape seed oil. Journal of Critical Reviews, 6(1), 1-6.
Ceteareth 20
1. Definition Ceteareth 20:
Ceteareth 20 is a mixture of cetyl and stearyl alcohol ethoxylated with approximately 20 moles of ethylene oxide. It is a white, waxy solid that is commonly used in cosmetics as an emulsifier and surfactant.2. Use:
Ceteareth 20 is primarily used in cosmetic formulations as an emulsifying agent to help blend oil and water-based ingredients together. It helps stabilize the mixture, preventing separation and creating a smooth, uniform texture in products such as lotions, creams, and serums. Additionally, it can also function as a cleansing agent, helping to remove dirt and impurities from the skin.3. Usage Ceteareth 20:
When using products containing Ceteareth 20, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing this ingredient to a larger area of skin. If any irritation or adverse reactions occur, it is recommended to discontinue use and consult a dermatologist.4. References:
- "Ceteareth-20." Cosmeticsinfo.org, www.cosmeticsinfo.org/ingredient/ceteareth-20.
- "Ceteareth-20." Truth In Aging, www.truthinaging.com/ingredients/ceteareth-20.
- "Ceteareth-20." Personal Care Council, www.personalcarecouncil.org/inci-name/ceteareth-20.
Panthenol
1. Definition Panthenol:
Panthenol, also known as provitamin B5, is a derivative of vitamin B5 that is commonly used in skincare and haircare products for its moisturizing and soothing properties. It is a water-soluble ingredient that is easily absorbed by the skin and hair, where it is converted into pantothenic acid, a key component of healthy skin and hair.2. Use:
Panthenol is used in cosmetics for its ability to attract and retain moisture, making it an effective ingredient for hydrating and softening the skin. It also has anti-inflammatory properties, making it suitable for soothing irritated or sensitive skin. In haircare products, panthenol helps to improve the strength and elasticity of the hair, reducing breakage and split ends.3. Usage Panthenol:
Panthenol can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and styling products. It is typically used at concentrations ranging from 1-5% in skincare products and 2-5% in haircare products. Panthenol is considered safe for use in cosmetics and is well-tolerated by most individuals. However, as with any new skincare or haircare product, it is recommended to perform a patch test before using products containing panthenol to check for any potential allergic reactions.4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.
- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.
- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.
Allantoin
1. Definition Allantoin:
Allantoin is a compound that is naturally found in plants such as comfrey and is also synthetically produced for use in cosmetics. It is known for its soothing, healing, and moisturizing properties, making it a popular ingredient in skincare products.2. Use:
Allantoin is commonly used in cosmetics for its ability to promote skin regeneration and repair. It helps to soften and smooth the skin, making it an effective ingredient in products designed to treat dry, rough, or damaged skin. Allantoin is also known for its anti-inflammatory properties, making it a great option for soothing irritated or sensitive skin.3. Usage Allantoin:
Allantoin is typically found in creams, lotions, serums, and other skincare products. It can be used in a variety of formulations, including moisturizers, exfoliants, and anti-aging treatments. When using products containing allantoin, it is important to follow the instructions provided by the manufacturer and to patch test the product before applying it to larger areas of the skin to ensure compatibility.4. References:
- Draelos, Z. D. (2010). Cosmeceuticals. Elsevier Health Sciences.
- Mukherjee, P. K., & Maity, N. (2011). Acute oral toxicity study of Allantoin in Swiss albino mice. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2(3), 1247-1251.
- Vaughn, A. R., Clark, A. K., Sivamani, R. K., & Shi, V. Y. (2019). Natural oils for skin-barrier repair: ancient compounds now backed by modern science. American Journal of Clinical Dermatology, 20(3), 285-295.