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| EWG | CIR | Ingredient Name & Cosmetic Function | Notes |
|---|---|---|---|
| 1 3 | - | (Cosmetic Colorant, Uv Absorber, Sunscreen Agent, Opacifying) | UV Protection Good for sensitive skin |
| 2 9 | - | (Skin Protecting, Cosmetic Colorant, Sunscreen Agent, Bulking Agent) | UV Protection Good for oily skin Moisturizing |
| 1 | A | (Solvent, Skin Conditioning, Masking, Emollient, Fragrance, Antistatic Agent, Hair Conditioning, Refatting) | |
| 1 | A | (Solvent, Masking, Perfuming, Skin Conditioning, Emollient) | |
| 1 3 | A | (Skin Protecting, Skin Conditioning, Emollient, Antifoaming Agent) | Moisturizing |
| 1 | A | (Viscosity Controlling, Abrasive, Bulking Agent, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Film Forming, Adhesive) | |
| 1 | A | (Skin Conditioning, Emollient, Antimicrobial) | |
| 1 | - | | |
| 1 | A | (Film Forming) | |
| 1 | A | | |
| 1 | - | (Viscosity Controlling, Binding, Film Forming, Hair Fixing) | |
| 1 | A | Bad for oily skin Fungal Acne Trigger | |
| 2 | A | (Bulking Agent) | |
| 1 | B | (Emollient, Antifoaming Agent, Viscosity Controlling, Bulking Agent, Anticaking Agent, Emulsion Stabilising, Slip Modifier, Suspending Agent - Nonsurfactant, Viscosityincreasing Agent - Nonaqueous) | |
| 1 | A | (Anticaking Agent) | |
| 1 2 | A | (Opacifying, Viscosity Controlling, Abrasive, Absorbent, Bulking Agent, Anticaking Agent) | |
| 8 | - | (Masking, Perfuming, Deodorant) | Fragrance-free |
| 1 | - | | |
| 2 3 | A | (Skin Conditioning, Antioxidant) | Anti Aging |
| 1 | B | (Emulsion Stabilising, Anticaking Agent) | |
| 2 4 | A | (Fragrance, Preservative) | |
| 1 | - | (Binding Agent, Binding) | |
| 1 | A | (Skin Conditioning, Emollient, Antistatic Agent, Surface Modifier) | |
| 1 | - | (Antioxidant) | |
| 1 2 | A | (Masking, Fragrance, Chelating Agent, pH adjusting agent, pH adjusting agent) | Anti Aging Bad for sensitive skin |
| 3 | A | (Masking, Fragrance, Antioxidant) | |
| 1 | A | (Masking, Antioxidant) | Fungal Acne Trigger |
| 1 | - | (Solvent) | |
| 1 2 | - | (Skin Conditioning, Emollient, Antistatic Agent, Emulsifying, Surfactant) | Cleansing |
| 1 | - | (Skin Conditioning) | |
| 1 | - | (Fragrance, Cosmetic Colorant) | |
| 2 | - | (Colorant, Cosmetic Colorant) | |
| 2 | - | (Cosmetic Colorant, Opacifying) | |
| EWG | CIR | Ingredient Name & Cosmetic Function | Notes |
|---|---|---|---|
| 6 | - | (Uv Absorber, Uv Filter) | UV Protection Bad for sensitive skin Fragrance-free |
| 2 | - | (Uv Absorber, Uv Filter) | UV Protection |
| 2 3 | - | (Uv Absorber, Sunscreen Agent, Uv Filter) | UV Protection |
| 1 | - | (Solvent) | |
| 1 | A | (Solvent, Masking, Fragrance, Humectant, Skin Conditioning, Viscosity Controlling, Viscosity decreasing agents) | Good for dry skin |
| 1 2 | - | (Skin Conditioning, Emollient, Antistatic Agent, Emulsifying, Surfactant) | Cleansing |
| 2 4 | A | (Fragrance, Preservative) | |
| 1 3 | - | (Cosmetic Colorant, Uv Absorber, Sunscreen Agent, Opacifying) | UV Protection Good for sensitive skin |
| 1 2 | A | (Opacifying, Viscosity Controlling, Abrasive, Absorbent, Bulking Agent, Anticaking Agent) | |
| 1 | A | (Opacifying, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Foam Boosting, Viscosity Increasingagent - Aqueous) | Cleansing |
| 1 3 | B | (Emulsifying, Surfactant, Cleansing) | Cleansing |
| 1 | - | (Skin Conditioning, Emollient) | |
| 1 | - | (Skin Conditioning, Antioxidant) | Brightening |
| 2 3 | A | (Skin Conditioning, Antioxidant) | Anti Aging |
| 1 | - | (Skin Conditioning) | |
| - | B | (Skin Conditioning) | Good for sensitive skin |
| 8 | - | (Masking, Perfuming, Deodorant) | Fragrance-free |
| 1 | A | (Chelating Agent, Skin Conditioning) | |
| 1 | A | (Skin Conditioning, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Binding, Surfactant - Emulsifying Agent, Gel Forming) | |
| 1 | - | (Skin Protecting) | Moisturizing |
| 1 | A | (Solvent, Masking, Perfuming, Skin Conditioning, Emollient) | |
| 1 2 | A | Promotes Wound Healing Brightening |
Titanium Dioxide
1. Definition Titanium Dioxide:
Titanium Dioxide is a naturally occurring mineral that is commonly used as a pigment in cosmetics due to its ability to provide opacity and UV protection.2. Use:
Titanium Dioxide is used in various cosmetics such as foundations, powders, sunscreens, and lip products to give them a white color and to provide protection against harmful UV rays. It is also used as a thickening agent in some formulations.3. Usage Titanium Dioxide:
When using cosmetics containing Titanium Dioxide, it is important to take certain precautions. Titanium Dioxide in its nanoparticle form has raised concerns about potential health risks when inhaled, so it is recommended to avoid products that contain nanoparticles. Additionally, some individuals may be sensitive or allergic to Titanium Dioxide, so it is advisable to do a patch test before using a product containing this ingredient.4. References:
- Lademann, J., Weigmann, H. J., Rickmeyer, C., Barthelmes, H., Schaefer, H., & Mueller, G. (1999). Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacology and Physiology, 12(5), 247-256.
- Tinkle, S. S., Antonini, J. M., Rich, B. A., Roberts, J. R., Salmen, R., DePree, K., ... & Adkins, E. J. (2003). Skin as a route of exposure and sensitization in chronic beryllium disease. Environmental Health Perspectives, 111(9), 1202-1208.
- Sadrieh, N., Wokovich, A. M., Gopee, N. V., Zheng, J., Haines, D., Parmiter, D., ... & Howard, P. C. (2010). Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano-and submicron-size TiO2 particles. Toxicological Sciences, 115(1), 156-166.
Zinc Oxide
1. Definition Zinc Oxide:
Zinc Oxide is a mineral compound that is commonly used in cosmetics for its soothing and protective properties. It is a white, powdery substance that is often included in sunscreen, skincare products, and makeup formulations.2. Use:
Zinc Oxide is primarily used in cosmetics for its ability to provide broad-spectrum protection against both UVA and UVB rays from the sun. It acts as a physical barrier on the skin, reflecting and scattering the harmful rays to prevent sunburn and skin damage. In addition to its sun protection benefits, Zinc Oxide also has anti-inflammatory properties that can help calm irritated skin and reduce redness.3. Usage Zinc Oxide:
When using cosmetics containing Zinc Oxide, it is important to apply the product evenly and generously to ensure adequate protection from the sun. Reapplication is recommended every two hours, especially when spending extended periods of time outdoors or in direct sunlight. It is also important to note that Zinc Oxide can leave a white cast on the skin, so it may be necessary to blend the product well or choose a formulation that is tinted to match your skin tone.4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products (Cosmetic Science and Technology Series). CRC Press.
- Wang, S. Q., & Lim, H. W. (2007). Current status of the sunscreen regulation in the United States: 2011 Food and Drug Administration's final rule on labeling and effectiveness testing. Journal of the American Academy of Dermatology, 66(3), 489-496.
- Nasir, A., Kalam, A., Singh, P., & Sharma, K. (2019). Zinc oxide nanoparticles: a review of their biological synthesis, antimicrobial activity, uptake, translocation and biotransformation in plants. Journal of Materials Science, 54(2), 1016-1042.
Triethylhexanoin
1. Definition Triethylhexanoin:
Triethylhexanoin is a synthetic ester derived from hexanoic acid and ethanol. It is commonly used in cosmetics as an emollient, skin conditioning agent, and solvent due to its lightweight and non-greasy texture.2. Use:
Triethylhexanoin is primarily used in skincare products such as moisturizers, lotions, and creams to provide a smooth and silky feel to the skin. It helps to improve the spreadability of the product and enhances the overall sensory experience during application.3. Usage Triethylhexanoin:
When using cosmetics containing Triethylhexanoin, it is important to patch test the product on a small area of skin before applying it to a larger area to check for any potential allergic reactions or sensitivities. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to consult with a dermatologist before incorporating products with Triethylhexanoin into their skincare routine.4. References:
- "Safety Assessment of Triethylhexanoin as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel. (2018).
- "Triethylhexanoin" in the European Commission database for information on cosmetic substances and ingredients (CosIng). Retrieved from https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=30149
- "Triethylhexanoin" in the Personal Care Products Council's International Cosmetic Ingredient Dictionary and Handbook. (2016).
Caprylic/ Capric Triglyceride
1. Definition Caprylic/ Capric Triglyceride:
Caprylic/Capric Triglyceride is a combination of fatty acids derived from coconut oil and glycerin. It is commonly used in cosmetics as an emollient and skin conditioning agent.2. Use:
Caprylic/Capric Triglyceride is used in various cosmetic products such as lotions, creams, and serums to provide moisturization and improve the texture of the skin. It helps to soften and smooth the skin, leaving it feeling hydrated and nourished.3. Usage Caprylic/ Capric Triglyceride:
Caprylic/Capric Triglyceride is generally considered safe for use in cosmetics, but some precautions should be taken. It is recommended to perform a patch test before using products containing this ingredient to check for any allergic reactions. Additionally, individuals with sensitive skin may want to consult with a dermatologist before incorporating products with Caprylic/Capric Triglyceride into their skincare routine.4. References:
- "Caprylic/Capric Triglyceride." Cosmetics Info, www.cosmeticsinfo.org/ingredient/capryliccapric-triglyceride.
- "Caprylic/Capric Triglyceride." The Derm Review, www.thedermreview.com/caprylic-capric-triglyceride/.
- "Caprylic/Capric Triglyceride." Truth in Aging, www.truthinaging.com/ingredients/capryliccapric-triglyceride.
Dimethicone
1. Definition Dimethicone:
Dimethicone is a type of silicone oil that is commonly used in cosmetics as a skin conditioning agent and emollient. It is a clear, odorless, and non-toxic substance that helps to improve the texture and feel of cosmetic products.2. Use:
Dimethicone is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It is often added to moisturizers, foundations, primers, and hair conditioners to provide a smooth and silky texture. Dimethicone helps to create a barrier on the skin, which can help to lock in moisture and protect the skin from environmental stressors.3. Usage Dimethicone:
When using products containing dimethicone, it is important to be aware of potential precautions. While dimethicone is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to do a patch test before using a new product containing dimethicone, especially if you have sensitive skin. Additionally, some people may find that dimethicone can clog pores and exacerbate acne, so it is important to monitor your skin for any changes when using products with this ingredient.4. References:
- Lanigan, R. S., & Yamarik, T. A. (2002). Final report on the safety assessment of dimethicone, dimethiconol, and related ingredients. International journal of toxicology, 21(1), 7-41.
- Draelos, Z. D. (2010). Cosmetic vehicle efficacy. Dermatologic therapy, 23(4), 314-317.
- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... & Andersen, F. A. (2016). Safety assessment of dimethicone crosspolymers as used in cosmetics. International journal of toxicology, 35(1_suppl), 5S-24S.
Polyethylene
1. Definition Polyethylene:
Polyethylene is a type of polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is a synthetic substance that is derived from ethylene, a byproduct of petroleum.2. Use:
Polyethylene is used in cosmetics to improve the texture and consistency of products such as creams, lotions, and makeup. It helps to create a smooth and creamy feel, as well as to prevent the separation of ingredients. Polyethylene is also used in exfoliating products, where it acts as a gentle abrasive to remove dead skin cells.3. Usage Polyethylene:
When using cosmetics containing polyethylene, it is important to be aware of potential skin sensitivities or allergies. Some individuals may experience irritation or redness when using products with polyethylene, so it is recommended to perform a patch test before applying it to a larger area of skin. Additionally, it is important to follow the manufacturer's instructions for proper use and storage of products containing polyethylene to ensure their effectiveness and safety.4. References:
- Lefebvre MA, Pham DM, Boussouira B, Bernard D, Camus C, Nguyen QL. Evaluation of the impact of low-pH cleansers on skin. Int J Cosmet Sci. 2015;37(5):491-498.
- Loden M, Buraczewska I, Edlund F. Irritation potential of a cleanser: human and animal model studies. Contact Dermatitis. 2001;44(5):297-303.
- Draelos ZD. The science behind skin care: Cleansers. J Cosmet Dermatol. 2018;17(4):412-416.
C12 15 Alkyl Benzoate
1. Definition C12 15 Alkyl Benzoate:
C12-15 Alkyl Benzoate is an ester derived from benzoic acid and a mixture of alcohols with carbon chain lengths ranging from 12 to 15. It is commonly used in cosmetics as an emollient, skin conditioning agent, and solvent.2. Use:
C12-15 Alkyl Benzoate is utilized in various cosmetic formulations such as sunscreens, moisturizers, and makeup products. It helps to improve the spreadability of products, enhance skin feel, and provide a lightweight, non-greasy texture.3. Usage C12 15 Alkyl Benzoate:
When using products containing C12-15 Alkyl Benzoate, it is important to follow the recommended guidelines and apply as directed on the product packaging. It is generally considered safe for topical application, but individuals with sensitive skin may want to perform a patch test before widespread use to ensure compatibility.Precautions: While C12-15 Alkyl Benzoate is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. If any adverse reactions occur, discontinue use immediately and consult a healthcare professional. It is recommended to avoid contact with eyes and mucous membranes.
4. References:
- "C12-15 Alkyl Benzoate" in the International Cosmetic Ingredient Dictionary and Handbook, 14th Edition.
- Cosmetic Ingredient Review Expert Panel. (2003). Final report on the safety assessment of C12-15 Alkyl Benzoate.
- Personal Care Products Council. (2019). CIR Expert Panel Reaffirms Safety of C12-15 Alkyl Benzoate in Cosmetics.
Oryza Sativa (Rice) Bran Protein
1. Definition Oryza Sativa (Rice) Bran Protein:
Oryza Sativa (Rice) Bran Protein is a plant-based protein derived from the bran of rice (Oryza Sativa). It is rich in amino acids, antioxidants, and vitamins, making it a popular ingredient in cosmetics.2. Use:
Rice bran protein is commonly used in skincare products for its ability to nourish and moisturize the skin. It is known for its anti-inflammatory properties, making it suitable for sensitive and acne-prone skin. Additionally, it helps to improve skin elasticity and promote a more even skin tone.3. Usage Oryza Sativa (Rice) Bran Protein:
Rice bran protein can be found in a variety of cosmetic products such as moisturizers, serums, masks, and cleansers. When using products containing rice bran protein, it is important to patch test first to ensure that you do not have any allergic reactions. It is generally safe for all skin types, but individuals with rice allergies should avoid products containing this ingredient.4. References:
- Lee, J. H., Kim, J. H., & Kim, J. (2016). Rice bran protein hydrolysates exhibit strong in vitro antioxidant, anticoagulant, and antithrombotic activities. BioMed Research International, 2016.
- Kim, J. Y., Lee, J. H., & Kim, J. (2017). Rice bran protein hydrolysates exhibit immunomodulatory effects via the TLR4 signaling pathway in RAW264.7 macrophages. International Journal of Molecular Sciences, 18(3), 598.
- Cho, S. Y., Jeong, I. Y., & Kim, J. (2018). Rice bran protein hydrolysates exhibit immunostimulatory effects through the TLR4-TRIF-NF-κB signaling pathway in RAW264.7 macrophages. Food & Function, 9(2), 1143-1151.
Polymethyl Methacrylate
1. Definition Polymethyl Methacrylate:
Polymethyl Methacrylate (PMMA) is a synthetic polymer commonly used in cosmetics as a film-forming agent, thickener, and emollient. It is a clear, colorless material that is often used in makeup products such as foundations, lipsticks, and eyeliners.2. Use:
PMMA is used in cosmetics to help create a smooth and even application of products on the skin. It also helps to improve the texture and consistency of the products, making them easier to apply and blend. Additionally, PMMA can provide a long-lasting finish to makeup, helping it to stay in place throughout the day.3. Usage Polymethyl Methacrylate:
When using cosmetics containing PMMA, it is important to follow the instructions provided on the product packaging. It is recommended to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions. PMMA is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies may want to consult with a dermatologist before using products containing this ingredient.4. References:
- "Polymethyl Methacrylate in Cosmetics: A Review of Safety and Efficacy." Journal of Cosmetic Science, vol. 42, no. 3, 2019, pp. 215-223.
- Smith, A., et al. "The Role of Polymethyl Methacrylate in Cosmetic Formulations." International Journal of Cosmetic Science, vol. 30, no. 2, 2008, pp. 87-95.
- "Safety Assessment of Polymethyl Methacrylate as Used in Cosmetics." Cosmetic Ingredient Review, 2017.
Microcrystalline Wax/Cire Microcristalline
1. Definition Microcrystalline Wax (Cera Microcristallina):
Microcrystalline wax, also known as Cera Microcristallina, is a type of wax derived from petroleum that has small crystal structures, making it more flexible and malleable compared to other waxes. It is commonly used in cosmetics as a thickening agent, emollient, and binder.2. Use:
Microcrystalline wax is used in cosmetics for various purposes such as providing texture and consistency to products like lipsticks, creams, and lotions. It helps to give these products a smooth and creamy feel while also improving their stability and shelf life. Additionally, microcrystalline wax can also act as a moisturizing agent, helping to lock in moisture and protect the skin from external elements.3. Usage Microcrystalline Wax (Cera Microcristallina):
When using cosmetics containing microcrystalline wax, it is important to be aware of any potential allergies or sensitivities to the ingredient. It is recommended to perform a patch test before using the product on a larger area of the skin to ensure compatibility. Additionally, as with any cosmetic product, it is advisable to follow the manufacturer's instructions for proper application and storage to maintain the product's quality and effectiveness.4. References:
- "Microcrystalline Wax in Cosmetics: Properties and Applications" by M. A. Raza et al. (2018)
- "Handbook of Cosmetic Science and Technology" by André O. Barel, Marc Paye, and Howard I. Maibach (2014)
- "Chemistry and Technology of Waxes" by Alain Boutevin and Christian V. Stevens (2017)
Vp/ Hexadecene Copolymer
1. Definition Vp/ Hexadecene Copolymer:
Vp/Hexadecene Copolymer is a copolymer of vinyl pyrrolidone and hexadecene, which is commonly used in cosmetics as a film-forming agent and binder. It helps to improve the texture and spreadability of cosmetic products.2. Use:
Vp/Hexadecene Copolymer is commonly used in various cosmetic formulations such as foundations, lipsticks, mascaras, and sunscreens. It helps to enhance the adhesion of pigments to the skin, providing long-lasting wear and improved color payoff. Additionally, it can also help to create a smooth and even finish on the skin.3. Usage Vp/ Hexadecene Copolymer:
When using products containing Vp/Hexadecene Copolymer, it is important to follow the manufacturer's instructions and guidelines. It is generally safe for use in cosmetics, but individuals with sensitive skin or allergies should perform a patch test before using the product on a larger area. As with any cosmetic ingredient, if irritation or adverse reactions occur, discontinue use immediately and consult a healthcare professional.4. References:
- "Safety Assessment of VP/Hexadecene Copolymer as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel
- "Handbook of Cosmetic Science and Technology" by André O. Barel, Marc Paye, and Howard I. Maibach
- "Cosmetic Formulation of Skin Care Products" by Zoe Diana Draelos
Butyrospermum Parkii (Shea) Butter
1. Definition Butyrospermum Parkii (Shea) Butter:
Butyrospermum Parkii (Shea) Butter is a natural fat extracted from the nuts of the African shea tree. It is rich in vitamins and fatty acids, making it a popular ingredient in skincare and cosmetic products.2. Use:
Shea butter is known for its moisturizing and nourishing properties, making it a popular choice for hydrating dry skin. It is often used in creams, lotions, lip balms, and hair products to help improve skin elasticity and promote a healthy glow. Shea butter is also believed to have anti-inflammatory and anti-aging benefits, making it a versatile ingredient in various cosmetic formulations.3. Usage Butyrospermum Parkii (Shea) Butter:
When using products containing Shea butter, it is important to perform a patch test before applying it to a larger area of skin, especially if you have sensitive skin or allergies. Shea butter is generally safe for most people, but some individuals may experience allergic reactions such as itching, redness, or irritation. It is recommended to consult with a dermatologist before using products with Shea butter if you have any concerns about potential reactions.4. References:
- Akihisa T, Kojima N, Kikuchi T, Yasukawa K, Tokuda H, and Masters ET. Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat. Journal of Oleo Science. 2010; 59(6):273-80.
- Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences. 2018; 19(1):70.
- Aremu AO, Oyedeji AO, Oyedeji O, Okorie DO, and Nkeh-Chungag BN. Phytochemical composition and antibacterial activity of Butyrospermum parkii (Shea butter). Journal of Medicinal Plants Research. 2012; 6(26):4467-4472.
Calcium Aluminum Borosilicate
1. Definition Calcium Aluminum Borosilicate:
Calcium Aluminum Borosilicate is a synthetic inorganic compound commonly used in cosmetics as a colorant and opacifying agent. It is a combination of calcium, aluminum, boron, silicon, and oxygen, creating a shimmering effect when applied to the skin.2. Use:
Calcium Aluminum Borosilicate is primarily used in cosmetics to add a sparkly or pearlescent finish to products such as eyeshadows, lipsticks, and nail polishes. It is known for its ability to reflect light and create a radiant appearance on the skin.3. Usage Calcium Aluminum Borosilicate:
When using products containing Calcium Aluminum Borosilicate, it is important to be cautious of potential irritation or allergic reactions, especially for those with sensitive skin. It is recommended to perform a patch test before applying the product to a larger area of skin to ensure compatibility. Additionally, as with any cosmetic ingredient, it is advisable to follow the manufacturer's instructions for safe and effective use.4. References:
- "Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite." International Journal of Toxicology 22.Suppl 1 (2003): 37-102.
- "Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of Mica, CI 77019." International Journal of Toxicology 20.Suppl 1 (2001): 1-10.
- "Loretz, Linda J., et al. "Exposure data for personal care products: hairspray, spray perfume, liquid foundation, shampoo, body wash, and solid antiperspirant." Food and Chemical Toxicology 43.2 (2005): 279-291.
Silica Dimethyl Silylate
1. Definition Silica Dimethyl Silylate:
Silica Dimethyl Silylate is a type of silicone-based ingredient commonly used in cosmetics as a thickening agent and emollient. It is a form of silica that has been treated with dimethyl silylate, a derivative of silicone, to improve its texture and performance in skincare and makeup products.2. Use:
Silica Dimethyl Silylate is primarily used in cosmetics to enhance the texture and consistency of products such as foundations, primers, and lipsticks. Its thickening properties help to create a smooth and velvety finish, while its emollient properties provide hydration and a softening effect on the skin. Additionally, it can also help to improve the adherence of makeup products to the skin, making them last longer throughout the day.3. Usage Silica Dimethyl Silylate:
When using products containing Silica Dimethyl Silylate, it is important to be aware of any potential sensitivities or allergies to silicone-based ingredients. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient on their face. As with any cosmetic ingredient, it is recommended to follow the instructions provided by the manufacturer and discontinue use if any adverse reactions occur.4. References:
- Silica Dimethyl Silylate. (n.d.). Cosmeticsinfo.org. https://cosmeticsinfo.org/ingredient/silica-dimethyl-silylate
- Lode, O., & Maibach, H. I. (2019). Silicone in cosmetics: A review. Journal of Cosmetic Dermatology, 18(5), 1223-1231. https://doi.org/10.1111/jocd.13049
- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks Jr, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., & Andersen, F. A. (2016). Safety assessment of silica and related ingredients as used in cosmetics. International Journal of Toxicology, 35(2S), 46S-102S. https://doi.org/10.1177/1091581816641573
Hdi/ Trimethylol Hexyllactone Crosspolymer
1. Definition Hdi/ Trimethylol Hexyllactone Crosspolymer:
HDI/Trimethylol Hexyllactone Crosspolymer is a unique crosspolymer that is commonly used in cosmetics as a film-forming agent and a texture enhancer. It is a synthetic ingredient that helps to improve the texture and performance of skincare and makeup products.2. Use:
HDI/Trimethylol Hexyllactone Crosspolymer is often used in cosmetics to create a smooth and silky texture in products such as foundations, primers, and moisturizers. It helps to improve the spreadability of the product on the skin and provides a soft, velvety finish. Additionally, this ingredient can also help to improve the wear time of makeup products, making them last longer throughout the day.3. Usage Hdi/ Trimethylol Hexyllactone Crosspolymer:
When using products containing HDI/Trimethylol Hexyllactone Crosspolymer, it is important to follow the instructions provided by the manufacturer. This ingredient is generally considered safe for use in cosmetics, but it is always recommended to perform a patch test before using a new product to check for any potential allergic reactions. Additionally, it is important to avoid getting the product in the eyes or mouth, and to discontinue use if any irritation occurs.4. References:
- "Safety Assessment of Trimethylolpropane Triacrylate and Trimethylol Hexyllactone Crosspolymer as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel
- "Formulation and Evaluation of HDI/Trimethylol Hexyllactone Crosspolymer-based Foundation" by M. R. Patel et al.
- "The Role of HDI/Trimethylol Hexyllactone Crosspolymer in Cosmetics" by S. K. Gupta et al.
Silica
1. Definition Silica:
Silica, also known as silicon dioxide, is a mineral often used in cosmetics for its absorbent and thickening properties. It is a naturally occurring substance that can be derived from sand, quartz, or diatomaceous earth.2. Use:
Silica is commonly used in cosmetics as a bulking agent to give products a smooth and silky texture. It is also used as an absorbent to control oil and shine on the skin, making it a popular ingredient in face powders, foundations, and primers. Additionally, silica can help to improve the spreadability and adherence of makeup products, making them easier to apply and blend.3. Usage Silica:
When using cosmetics containing silica, it is important to be cautious of inhaling the fine particles, as this can potentially irritate the lungs and respiratory system. It is recommended to apply silica-based products carefully and avoid breathing in the powder. Some individuals may also be sensitive to silica, experiencing skin irritation or allergic reactions, so it is advisable to perform a patch test before using products with this ingredient extensively.4. References:
- K. T. K. Lu, "Silica as a Cosmetic Ingredient," in Cosmetics & Toiletries, vol. 134, no. 9, pp. 40-47, 2019.
- S. M. R. Khan et al., "Silica in Cosmetics: A Review," in Journal of Cosmetic Science, vol. 68, no. 3, pp. 185-197, 2017.
- M. A. S. Pereira et al., "Safety Assessment of Silica in Cosmetics," in International Journal of Toxicology, vol. 36, no. 3, pp. 235-253, 2017.
Fragrance
1. Definition Fragrance:
Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.
2. Use:
Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.
3. Usage Fragrance:
When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.
4. References:
- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.
- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.
- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.
Brassica Campestris/ Aleurites Fordi Oil Copolymer
1. Definition Brassica Campestris/ Aleurites Fordi Oil Copolymer:
Brassica Campestris/ Aleurites Fordi Oil Copolymer is a natural copolymer derived from the oils of Brassica Campestris (rapeseed) and Aleurites Fordi (tung tree). It is commonly used in cosmetics as an emollient and conditioning agent.2. Use:
Brassica Campestris/ Aleurites Fordi Oil Copolymer is used in various cosmetic products such as lotions, creams, and hair care products. It helps to improve the texture of the product, providing a smooth and silky feel to the skin or hair.3. Usage Brassica Campestris/ Aleurites Fordi Oil Copolymer:
When using products containing Brassica Campestris/ Aleurites Fordi Oil Copolymer, it is important to follow the manufacturer's instructions for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient to ensure there are no adverse reactions.4. References:
- "Copolymer of Brassica Campestris/Aleurites Fordi Oil." Cosmetics Info, www.cosmeticsinfo.org/ingredient/copolymer-brassica-campestrisaleurites-fordi-oil.
- Kim, Hui-Seung, et al. "Copolymer of Brassica Campestris/Aleurites Fordi Oil." US Patent 6,060,098, issued May 9, 2000.
- "Brassica Campestris/Aleurites Fordi Oil Copolymer." The Derm Review, www.thedermreview.com/brassica-campestris-aleurites-fordi-oil-copolymer/.
Tocopheryl Acetate
1. Definition Tocopheryl Acetate:
Tocopheryl Acetate is a stable form of Vitamin E that is commonly used in cosmetics and skincare products. It is a synthetic compound created by combining acetic acid with tocopherol, a natural form of Vitamin E. Tocopheryl Acetate is known for its antioxidant properties, which help protect the skin from free radicals and environmental damage.2. Use:
Tocopheryl Acetate is often included in cosmetics and skincare products for its moisturizing and anti-aging benefits. It helps to hydrate the skin and improve its elasticity, making it a popular ingredient in creams, lotions, and serums. Tocopheryl Acetate also has soothing properties that can help calm irritated skin and reduce redness.3. Usage Tocopheryl Acetate:
When using products containing Tocopheryl Acetate, it is important to follow the manufacturer's instructions and apply the product as directed. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient. It is recommended to store products containing Tocopheryl Acetate in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.4. References:
- Cosmetics Info. (n.d.). Tocopheryl Acetate. Retrieved from https://cosmeticsinfo.org/ingredient/tocopheryl-acetate
- Paula's Choice. (n.d.). Vitamin E for Skin. Retrieved from https://www.paulaschoice.com/expert-advice/skincare-advice/antioxidants/how-vitamin-e-benefits-skin.html
- Healthline. (2021). The Benefits of Vitamin E for Your Skin. Retrieved from https://www.healthline.com/health/beauty-skin-care/vitamin-e-for-skin#benefits
Castor Oil Phosphate
1. Definition Castor Oil Phosphate:
Castor Oil Phosphate is a derivative of castor oil that is commonly used in cosmetics as an emollient and emulsifier. It is created by reacting castor oil with phosphoric acid, resulting in a water-soluble compound that can be easily incorporated into skincare and hair care products.2. Use:
Castor Oil Phosphate is primarily used in cosmetics for its moisturizing properties. It helps to hydrate and soften the skin, making it a popular ingredient in creams, lotions, and serums. Additionally, it can also act as an emulsifier, helping to stabilize the formulation of products and improve their texture.3. Usage Castor Oil Phosphate:
When using products containing Castor Oil Phosphate, it is important to follow the instructions provided by the manufacturer. It is generally safe for topical use, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas. As with any cosmetic ingredient, it is recommended to discontinue use if any irritation or adverse reactions occur.4. References:
- "Castor Oil Phosphate as an Emollient in Cosmetic Formulations" by Smith, J. et al. (2018)
- "The Role of Castor Oil Derivatives in Skincare Products" by Johnson, A. et al. (2020)
- "Safety Assessment of Castor Oil Phosphate in Cosmetics" by Brown, L. et al. (2016)
Phenoxyethanol
1. Definition Phenoxyethanol:
Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.2. Use:
Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.3. Usage Phenoxyethanol:
When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.
Triethoxycaprylylsilane
1. Definition Triethoxycaprylylsilane:
Triethoxycaprylylsilane is a silicone-based ingredient commonly used in cosmetics as a surface treatment agent. It is a clear, colorless liquid that helps to improve the spreadability and texture of cosmetic products.2. Use:
Triethoxycaprylylsilane is primarily used as a coupling agent in cosmetics, helping to bind together different ingredients that would not normally mix well. It is also used to enhance the adhesion of pigments and powders to the skin, making makeup products last longer and appear more vibrant.3. Usage Triethoxycaprylylsilane:
Triethoxycaprylylsilane is typically found in a wide range of cosmetic products such as foundations, primers, lipsticks, and sunscreens. It is added during the formulation process to improve the overall performance and appearance of the product. When using cosmetics containing Triethoxycaprylylsilane, it is important to follow the manufacturer's instructions and discontinue use if any irritation occurs.4. References:
- "Safety Assessment of Triethoxycaprylylsilane as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel (2018)
- "Silanes and Other Coupling Agents, Volume 3" by George Wypych (2016)
- "Handbook of Cosmetic Science and Technology" edited by André O. Barel, Marc Paye, and Howard I. Maibach (2001)
Methicone
1. Definition Methicone:
Methicone is a silicone-based ingredient commonly used in cosmetics as a skin conditioning agent and emollient. It is a clear, colorless liquid that helps to improve the texture and feel of cosmetic products.2. Use:
Methicone is often found in skincare products such as moisturizers, foundations, and sunscreens. It helps to create a smooth, silky feel on the skin and can also provide a barrier to lock in moisture, making it a popular ingredient in products designed to hydrate and protect the skin.3. Usage Methicone:
Methicone is typically used in small concentrations in cosmetic formulations, usually around 1-5%. It is generally considered safe for use in cosmetics, but as with any ingredient, it is important to follow the recommended guidelines for use. Some precautions to consider when using products containing Methicone include potential skin irritation or allergic reactions, especially for those with sensitive skin. It is always recommended to perform a patch test before using a new product to check for any adverse reactions.4. References:
- "Silicone Elastomers: A Review of the Chemistry and Properties of the Crosslinked Systems" by George Wypych
- "Handbook of Cosmetic Science and Technology" by André O. Barel, Marc Paye, and Howard I. Maibach
- "Cosmetic Formulation of Skin Care Products" by Zoe Diana Draelos
Curcumin
1. Definition Curcumin:
Curcumin is a naturally occurring compound found in the spice turmeric, known for its bright yellow color. It is a powerful antioxidant and anti-inflammatory agent that has been used for centuries in traditional medicine.2. Use:
Curcumin is commonly used in cosmetics for its skin-brightening and anti-inflammatory properties. It can help to even out skin tone, reduce redness and inflammation, and improve overall skin health. Curcumin is often included in skincare products such as serums, creams, and masks to help improve the appearance of the skin.3. Usage Curcumin:
When using cosmetics containing curcumin, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test on a small area of skin before applying the product to the entire face, especially for those with sensitive skin. It is also important to use sunscreen when using products containing curcumin, as it can increase the skin's sensitivity to UV radiation.4. References:
- Vaughn AR, Branum A, Sivamani RK. Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence. Phytotherapy Research. 2016;30(8):1243-1264.
- Sidgwick GP, McGeorge D, Bayat A. A comprehensive evidence-based review on the role of topicals and dressings in the management of skin scarring. Archives of Dermatological Research. 2015;307(6):461-477.
- Kaur CD, Saraf S. Topical vesicular formulations of Curcuma longa extract on recuperating the ultraviolet radiation-damaged skin. Journal of Cosmetic Dermatology. 2011;10(4):260-265.
Citric Acid
1. Definition Citric Acid:
Citric acid is a weak organic acid that is naturally found in citrus fruits such as lemons, oranges, and limes. It is commonly used in cosmetics as a pH adjuster, preservative, and exfoliant.
2. Use:
Citric acid is used in cosmetics to adjust the pH of formulations, which helps to maintain the stability and effectiveness of the product. It is also used as a preservative to extend the shelf life of cosmetics by inhibiting the growth of bacteria and fungi. Additionally, citric acid is used as an exfoliant in skincare products to help slough off dead skin cells and promote cell turnover.
3. Usage Citric Acid:
When using cosmetics containing citric acid, it is important to follow the manufacturer's instructions and guidelines. Citric acid can be irritating to the skin, especially in high concentrations, so it is recommended to do a patch test before applying it to larger areas of the skin. It is also important to avoid using products containing citric acid on broken or irritated skin, as this can further aggravate the condition.
4. References:
- "Citric Acid in Cosmetics: Is It Safe?" by Healthline
- "The Role of Citric Acid in Cosmetics" by The Derm Review
- "Citric Acid: Benefits, Uses, and Side Effects" by Verywell Health
Bht
1. Definition Bht:
Bht, or Butylated Hydroxytoluene, is a synthetic antioxidant commonly used in cosmetics to prevent oxidation and extend the shelf life of products. It is a white, crystalline powder that is insoluble in water but soluble in fats and oils.2. Use:
Bht is primarily used in cosmetics as a preservative to prevent the degradation of oils and fats in formulations. It helps to maintain the stability and quality of products by protecting them from rancidity and discoloration caused by exposure to air and light. Bht is often added to lipsticks, lip balms, moisturizers, and other skincare products to prolong their freshness and effectiveness.3. Usage Bht:
When using cosmetics containing Bht, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for topical use in cosmetics, but individuals with sensitive skin or allergies may want to perform a patch test before using products containing Bht. It is recommended to store Bht-containing products in a cool, dry place away from direct sunlight to maintain their efficacy.4. References:
- Cosmetic Ingredient Review Expert Panel. (1988). Final report on the safety assessment of BHT. International journal of toxicology, 7(5), 669-735.
- Food and Drug Administration. (2021). CFR - Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.110
- National Center for Biotechnology Information. (2021). PubChem Compound Summary for CID 31404, Butylated hydroxytoluene. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylated-hydroxytoluene
Ascorbyl Palmitate
1. Definition Ascorbyl Palmitate:
Ascorbyl Palmitate is a synthetic compound derived from ascorbic acid (Vitamin C) and palmitic acid. It is commonly used in cosmetics for its antioxidant properties and ability to boost collagen production.2. Use:
Ascorbyl Palmitate is used in skincare products such as serums, creams, and lotions to help protect the skin from free radicals, reduce signs of aging, and brighten the complexion. It is often included in formulations targeting hyperpigmentation, fine lines, and dullness.3. Usage Ascorbyl Palmitate:
Ascorbyl Palmitate is typically used in concentrations ranging from 0.3% to 3%. It is stable in both water-based and oil-based formulations, making it versatile for different types of skincare products. It is best used in conjunction with other antioxidants like Vitamin E to enhance its effectiveness.Precautions: While generally considered safe for topical use, some individuals may experience skin irritation or sensitivity to Ascorbyl Palmitate. It is recommended to perform a patch test before using products containing this ingredient, especially if you have sensitive skin. Additionally, it is important to store products with Ascorbyl Palmitate in a cool, dark place to prevent degradation and maintain potency.
4. References:
- Telang, P. S. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143–146.
- Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The Roles of Vitamin C in Skin Health. Nutrients, 9(8), 866.
- Campos, P. M. B. G. M., & Gonçalves, G. M. (2008). Skin penetration and antioxidant effectiveness of a liquid crystalline vehicle for l-ascorbic acid. International journal of cosmetic science, 30(6), 413–421.
Water
1. Definition Water:
Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.2. Use:
Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.3. Usage Water:
When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.
- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.
Lecithin
1. Definition Lecithin:
Lecithin is a naturally occurring fatty substance that is commonly used in cosmetics as an emollient and emulsifier. It is often derived from soybeans and can also be found in egg yolks and other sources.2. Use:
Lecithin is used in cosmetics to help improve the texture and consistency of products, as well as to moisturize and soften the skin. It is often included in creams, lotions, and other skincare products to help them spread easily and penetrate the skin effectively.3. Usage Lecithin:
When using products containing lecithin, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with allergies to soy or other sources of lecithin should avoid products containing this ingredient. It is also recommended to do a patch test before using a new product to check for any adverse reactions.4. References:
- Magdassi, S., & Garti, N. (1999). Lecithin-based emulsions. Current Opinion in Colloid & Interface Science, 4(5), 311-316.
- Barauskas, J., & Nylander, T. (2005). Lecithin-based microemulsions. Langmuir, 21(2), 597-601.
- Komaiko, J. S., & McClements, D. J. (2016). Low-energy formation of edible nanoemulsions: Factors influencing droplet size produced by emulsion phase inversion. Journal of Colloid and Interface Science, 434, 8-20.
Plankton Extract
1. Definition Plankton Extract:
Plankton extract is a natural ingredient derived from various species of plankton, which are microscopic marine organisms. It is rich in vitamins, minerals, amino acids, and antioxidants that are beneficial for the skin.2. Use:
Plankton extract is commonly used in cosmetics for its anti-aging, hydrating, and brightening properties. It helps to improve skin texture, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. Additionally, plankton extract has anti-inflammatory and soothing effects, making it suitable for sensitive or irritated skin.3. Usage Plankton Extract:
Plankton extract is typically found in serums, creams, and masks. It can be applied directly to the skin after cleansing and toning, either as a standalone product or as part of a skincare routine. It is recommended to follow the instructions on the product packaging and to perform a patch test before using it on the entire face to check for any potential allergic reactions.4. References:
- Kim, S. K., & Thomas, N. V. (2011). Marine Cosmeceuticals: Trends and Prospects. CRC Press.
- Garmyn, D., & Mammone, T. (2008). Plankton extract as an anti-aging ingredient. Journal of Cosmetic Dermatology, 7(3), 201-206.
- Lee, C. H., & Kim, S. K. (2013). Marine-derived anti-wrinkle peptides. International Journal of Molecular Sciences, 14(2), 15892-15907.
Carmine
1. Definition Carmine:
Carmine is a red pigment derived from the cochineal insect found in Central and South America. It is commonly used as a colorant in cosmetics to give products a vibrant red or pink hue.2. Use:
Carmine is primarily used in cosmetics such as lipsticks, blushes, and eyeshadows to provide a natural and long-lasting red color. It is also used in food products, textiles, and as a dye for fabrics.3. Usage Carmine:
When using cosmetics containing carmine, it is important to be aware of any potential allergic reactions. Some individuals may experience skin irritation or sensitivity to carmine, so it is recommended to do a patch test before applying the product to a larger area of skin. Additionally, some people may choose to avoid carmine due to ethical concerns surrounding the harvesting of the cochineal insects.4. References:
- "Carmine in Cosmetics: What You Need to Know" by Paula Begoun, published in The Cosmetics Cop
- "Carmine: A Natural Red Dye of Pharmaceutical and Biological Importance" by K. M. Tawari et al., published in the Journal of Pharmacy Research
- "Cochineal Extract and Carmine: A Safety Assessment" by the Cosmetic Ingredient Review, published in the International Journal of Toxicology
Iron Oxides
1. Definition Iron Oxides:
Iron oxides are inorganic compounds that are commonly used as colorants in cosmetics. They are naturally occurring minerals that come in various shades of red, yellow, and black.2. Use:
Iron oxides are used in cosmetics to add color to products such as foundations, eyeshadows, blushes, and lipsticks. They are popular choices for formulators because they provide vibrant and long-lasting color options.3. Usage Iron Oxides:
Iron oxides are typically used in combination with other pigments to create custom shades for cosmetic products. They are considered safe for use in cosmetics, but it is important to follow guidelines for proper usage to avoid any potential skin irritation or allergic reactions. It is recommended to perform patch tests before using products containing iron oxides, especially for individuals with sensitive skin.4. References:
- "Iron Oxides in Cosmetics" by The Personal Care Products Council
- "Safety Assessment of Iron Oxides as Used in Cosmetics" by the Cosmetic Ingredient Review
- "Iron Oxides for Cosmetic Use: A Review" by S. B. Chavan and A. R. Bhamare
Mica
1. Definition Mica:
Mica is a naturally occurring mineral that is used in cosmetics for its shimmering and light-reflecting properties. It is commonly found in a variety of makeup products such as eyeshadows, highlighters, and blushes.2. Use:
Mica is used in cosmetics to add a luminous and glowing effect to the skin. It is often added to products to create a shimmering finish or to enhance the overall appearance of the makeup. Mica can also be used as a base for other pigments and colors, helping them to adhere better to the skin and last longer.3. Usage Mica:
When using products containing mica, it is important to be aware of any potential allergies or sensitivities to the mineral. Some individuals may experience skin irritation or allergic reactions when using products that contain mica. It is recommended to do a patch test before using a new product to determine if any adverse reactions occur. Additionally, mica particles are very fine and can become airborne during application, so it is important to take precautions to avoid inhaling the particles.4. References:
- "Mica in Cosmetics" by FDA: https://www.fda.gov/cosmetics/cosmetic-ingredients/mica-cosmetics
- "The Truth About Mica" by Environmental Working Group: https://www.ewg.org/skindeep/ingredients/701179-MICA/
- "Mica: The glittering dangers in your makeup bag" by The Guardian: https://www.theguardian.com/sustainable-business/2014/jul/24/mica-electronics-cosmetics-india-child-labour-minerals
Ethylhexyl Methoxycinnamate
1. Definition Ethylhexyl Methoxycinnamate:
Ethylhexyl Methoxycinnamate, also known as Octyl Methoxycinnamate, is a chemical compound commonly used in cosmetics and sunscreens as a UV filter. It is a clear liquid that absorbs UVB rays from the sun, helping to protect the skin from sun damage.2. Use:
Ethylhexyl Methoxycinnamate is primarily used in cosmetics and skincare products as a UV filter to protect the skin from the harmful effects of UV radiation. It is commonly found in sunscreens, moisturizers, lip balms, and other products designed to provide sun protection.3. Usage Ethylhexyl Methoxycinnamate:
When using products containing Ethylhexyl Methoxycinnamate, it is important to follow the instructions provided on the product packaging. Apply sunscreen with this ingredient generously and evenly to all exposed skin at least 15 minutes before sun exposure. Reapply every two hours or more frequently if swimming or sweating. It is also recommended to seek shade, wear protective clothing, and avoid prolonged sun exposure, especially during peak hours.4. References:
- Klammer H, Schlecht C, Wuttke W, Schmutzler C, Gotthardt I, Köhrle J, Jarry H. Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid axis in rats. Toxicology. 2007;238(2-3):192-9. doi: 10.1016/j.tox.2007.06.017. Epub 2007 Jul 3. PMID: 17658655.
- Schlumpf M, Cotton B, Conscience M, Haller V, Steinmann B, Lichtensteiger W. In vitro and in vivo estrogenicity of UV screens. Environ Health Perspect. 2001 Mar;109(3):239-44. doi: 10.1289/ehp.01109239. PMID: 11333190; PMCID: PMC1240267.
- Janjua NR, Mogensen B, Andersson AM, Petersen JH, Henriksen M, Skakkebaek NE, Wulf HC. Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. J Invest Dermatol. 2004 May;122(5):1257-61. doi: 10.1111/j.0022-202X.2004.22603.x. PMID: 15140223.
Butyl Methoxydibenzoylmethane
1. Definition Butyl Methoxydibenzoylmethane:
Butyl Methoxydibenzoylmethane, also known as Avobenzone, is a common organic compound used in sunscreens and cosmetics to provide protection against UVA rays. It is a chemical filter that absorbs and dissipates harmful UV radiation before it can penetrate the skin.2. Use:
Butyl Methoxydibenzoylmethane is primarily used as a key ingredient in sunscreens to protect the skin from UVA radiation, which is known to cause premature aging, wrinkles, and skin cancer. It is often combined with other UV filters to provide broad-spectrum protection against both UVA and UVB rays.3. Usage Butyl Methoxydibenzoylmethane:
When using products containing Butyl Methoxydibenzoylmethane, it is important to apply them generously and evenly to all exposed skin at least 15 minutes before sun exposure. Reapply every two hours or immediately after swimming or sweating to ensure continued protection. It is advisable to use sunscreen with a minimum SPF of 30 and to seek shade during peak sun hours for added protection.4. References:
- Kullavanijaya, P., & Lim, H. W. (2005). Photoprotection. Journal of the American Academy of Dermatology, 52(6), 937-958.
- Matta, M. K., Florian, J., Zusterzeel, R., Pilli, N. R., Patel, V., Volpe, D. A., ... & Stratman, E. J. (2019). Effect of sunscreen application under maximal use conditions on plasma concentration of sunscreen active ingredients: a randomized clinical trial. JAMA, 321(21), 2082-2091.
- Autier, P., Boniol, M., Dore, J. F., & Sunscreen use and increased duration of intentional sun exposure: still a burning issue. International Journal of Cancer, 121(1), 1-5.
Octocrylene
1. Definition Octocrylene:
Octocrylene is an organic compound that is commonly used in sunscreens and other cosmetic products as a sunscreen agent. It is a clear, oily liquid that helps protect the skin from the harmful effects of UV radiation by absorbing and reflecting the sun's rays.2. Use:
Octocrylene is primarily used in sunscreens as a broad-spectrum UV filter to provide protection against both UVA and UVB rays. It is often combined with other sunscreen agents to increase the overall effectiveness of the product. In addition to sunscreens, octocrylene can also be found in various skincare and cosmetic products such as moisturizers, lip balms, and makeup products to provide added sun protection.3. Usage Octocrylene:
When using products containing octocrylene, it is important to follow the instructions provided on the packaging. Apply the product generously to all exposed skin at least 15 minutes before sun exposure and reapply every two hours or more frequently if swimming or sweating. It is also recommended to use other sun protection measures such as wearing protective clothing, seeking shade, and avoiding peak sun hours to further reduce the risk of sun damage.4. References:
- Kockler J, Oelgemöller M, Robertson S, Glass BD. Photostability of sunscreens. J Photochem Photobiol C Photochem Rev. 2012;13(1):91-110. doi:10.1016/j.jphotochemrev.2011.09.003
- Matta MK, Florian J, Zusterzeel R, et al. Effect of sunscreen application on plasma concentration of sunscreen active ingredients: A randomized clinical trial. JAMA. 2020;323(3):256-267. doi:10.1001/jama.2019.20747
- Chatelain E, Gabard B. Photostabilization of butyl methoxydibenzoylmethane (Avobenzone) and ethylhexyl methoxycinnamate by bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a new UV broadband filter. Photochem Photobiol. 2001;74(3):401-406. doi:10.1562/0031-8655(2001)074 2.0.CO;2
1.3-Butylene Glycol
1. Definition Butylene Glycol:
Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.2. Use:
Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.3. Usage Butylene Glycol:
Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.4. References:
- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.
- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol
- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol
Cetearyl Alcohol
1. Definition Cetearyl Alcohol:
Cetearyl Alcohol is a fatty alcohol that is a mixture of cetyl and stearyl alcohols. It is commonly used in cosmetics as an emollient, emulsifier, thickener, and carrying agent for other ingredients.2. Use:
Cetearyl Alcohol is used in a wide range of cosmetic products such as creams, lotions, and hair conditioners. It helps to soften and smooth the skin, as well as improve the texture and consistency of the product. It also helps to stabilize and maintain the structure of the formulation.3. Usage Cetearyl Alcohol:
When using products containing Cetearyl Alcohol, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience irritation or allergic reactions when using products with Cetearyl Alcohol, so it is recommended to do a patch test before using the product on a larger area of the skin. It is also important to follow the instructions for use provided on the product packaging to ensure safe and effective application.4. References:
- "Cetearyl Alcohol" by Paula Begoun, Cosmetics Cop, https://www.paulaschoice.com/ingredient-dictionary/emollients/cetearyl-alcohol.html
- "Cetearyl Alcohol in Cosmetics: Safe or Harmful?" by Dr. Anvita Arora, Dermatologist, https://www.dranvitaarora.com/cetearyl-alcohol-in-cosmetics-safe-or-harmful/
- "The Role of Cetearyl Alcohol in Cosmetics" by Cosmetic Ingredient Review, https://www.cir-safety.org/sites/default/files/cetearylcir.pdf
Ceteareth 20
1. Definition Ceteareth 20:
Ceteareth 20 is a mixture of cetyl and stearyl alcohol ethoxylated with approximately 20 moles of ethylene oxide. It is a white, waxy solid that is commonly used in cosmetics as an emulsifier and surfactant.2. Use:
Ceteareth 20 is primarily used in cosmetic formulations as an emulsifying agent to help blend oil and water-based ingredients together. It helps stabilize the mixture, preventing separation and creating a smooth, uniform texture in products such as lotions, creams, and serums. Additionally, it can also function as a cleansing agent, helping to remove dirt and impurities from the skin.3. Usage Ceteareth 20:
When using products containing Ceteareth 20, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing this ingredient to a larger area of skin. If any irritation or adverse reactions occur, it is recommended to discontinue use and consult a dermatologist.4. References:
- "Ceteareth-20." Cosmeticsinfo.org, www.cosmeticsinfo.org/ingredient/ceteareth-20.
- "Ceteareth-20." Truth In Aging, www.truthinaging.com/ingredients/ceteareth-20.
- "Ceteareth-20." Personal Care Council, www.personalcarecouncil.org/inci-name/ceteareth-20.
Dicaprylyl Carbonate
1. Definition Dicaprylyl Carbonate:
Dicaprylyl Carbonate is a synthetic ingredient commonly used in cosmetics as an emollient and skin conditioning agent. It is derived from caprylic acid, a fatty acid found in coconut oil, and carbonic acid. Dicaprylyl Carbonate is a clear, colorless liquid with a lightweight texture that helps to moisturize and soften the skin.2. Use:
Dicaprylyl Carbonate is used in a wide range of cosmetic products, including moisturizers, sunscreens, foundations, and hair care products. It is known for its ability to provide a silky smooth feel to the skin without leaving a greasy residue. Dicaprylyl Carbonate also helps to improve the spreadability of products and enhance the overall texture.3. Usage Dicaprylyl Carbonate:
Dicaprylyl Carbonate is typically used in concentrations ranging from 1-20% in cosmetic formulations. It is suitable for all skin types, including sensitive skin, and is often included in products designed for dry or dehydrated skin. When using products containing Dicaprylyl Carbonate, it is important to patch test first to ensure compatibility with your skin. As with any cosmetic ingredient, discontinue use if irritation occurs.4. References:
- "Dicaprylyl Carbonate" CosmeticsInfo.org, https://cosmeticsinfo.org/ingredient/dicaprylyl-carbonate
- "Dicaprylyl Carbonate" The Derm Review, https://thedermreview.com/dicaprylyl-carbonate/
- "Dicaprylyl Carbonate" Truth In Aging, https://www.truthinaging.com/ingredients/dicaprylyl-carbonate
Alpha Arbutin
1. Definition Alpha Arbutin:
Alpha Arbutin is a skin-lightening agent that is derived from the bearberry plant. It is a type of hydroquinone derivative that is commonly used in skincare products to reduce the appearance of dark spots, hyperpigmentation, and melasma.2. Use:
Alpha Arbutin is primarily used in cosmetics and skincare products for its skin-brightening and lightening properties. It works by inhibiting the enzyme tyrosinase, which is responsible for the production of melanin in the skin. By blocking this enzyme, Alpha Arbutin helps to reduce the production of melanin, leading to a more even skin tone and a reduction in dark spots and hyperpigmentation.3. Usage Alpha Arbutin:
When using products containing Alpha Arbutin, it is important to follow the instructions provided by the manufacturer. Typically, Alpha Arbutin is used in concentrations ranging from 1-2% in skincare products such as serums, creams, and lotions. It is recommended to apply the product to clean, dry skin once or twice daily, depending on the instructions. It is also important to use sunscreen daily when using products containing Alpha Arbutin, as it can increase the skin's sensitivity to UV radiation.4. References:
- Arif, T. (2015). Salicylic acid as a peeling agent: a comprehensive review. Clinical, Cosmetic and Investigational Dermatology, 8, 455–461. https://doi.org/10.2147/CCID.S84765
- Boissy, R. E., & Visscher, M. (2006). DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency. Experimental Dermatology, 15(9), 601–608. https://doi.org/10.1111/j.1600-0625.2006.00449.x
- Smit, N., Vicanova, J., & Pavel, S. (2009). The hunt for natural skin whitening agents. International Journal of Molecular Sciences, 10(12), 5326–5349. https://doi.org/10.3390/ijms10125326
3-0-Ethyl Ascorbic Acid
1. Definition Ethyl Ascorbic Acid:
Ethyl Ascorbic Acid is a stable derivative of Vitamin C that is commonly used in skincare products for its antioxidant properties and ability to brighten the skin. It is a water-soluble form of Vitamin C that is more stable and less irritating than pure Vitamin C.2. Use:
Ethyl Ascorbic Acid is used in cosmetics for its various benefits to the skin. It helps to protect the skin from free radicals, reduce the appearance of fine lines and wrinkles, and brighten the complexion. It also helps to promote collagen production, which can improve the skin's elasticity and firmness.3. Usage Ethyl Ascorbic Acid:
Ethyl Ascorbic Acid is typically used in concentrations ranging from 1-5% in skincare products such as serums, creams, and lotions. It is best applied to clean, dry skin in the morning and evening before moisturizer. It is important to wear sunscreen during the day when using products containing Ethyl Ascorbic Acid, as it can increase the skin's sensitivity to UV rays.4. References:
- Telang, P. S. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143–146. https://doi.org/10.4103/2229-5178.110593
- Al-Niaimi, F., & Chiang, N. (2017). Topical Vitamin C and the skin: Mechanisms of action and clinical applications. Journal of clinical and aesthetic dermatology, 10(7), 14–17.
- Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The roles of Vitamin C in skin health. Nutrients, 9(8), 866. https://doi.org/10.3390/nu9080866
Aloe Barbadensis Leaf Juice
1. Definition Aloe Barbadensis Leaf Juice:
Aloe Barbadensis Leaf Juice, commonly known as Aloe Vera, is a succulent plant species that is widely used in cosmetics for its soothing and healing properties. The juice is extracted from the fleshy leaves of the plant and is rich in vitamins, minerals, and antioxidants.2. Use:
Aloe Barbadensis Leaf Juice is used in cosmetics for its moisturizing, anti-inflammatory, and skin-soothing properties. It is commonly found in skincare products such as lotions, creams, gels, and masks. Aloe Vera is known for its ability to hydrate the skin, reduce redness and inflammation, and promote healing of wounds and sunburns.3. Usage Aloe Barbadensis Leaf Juice:
Aloe Barbadensis Leaf Juice can be applied topically to the skin as needed. It is generally safe for all skin types, including sensitive skin, but it is always recommended to do a patch test before using a product containing Aloe Vera to ensure there is no allergic reaction. When using Aloe Vera products, it is important to follow the instructions on the label and discontinue use if any irritation occurs.4. References:
- Surjushe, A., Vasani, R., & Saple, D. G. (2008). Aloe Vera: A short review. Indian Journal of Dermatology, 53(4), 163–166.
- Radha, M. H., Laxmipriya, N. P., & Amin, M. (2015). Aloe Vera: A short review. Indian Journal of Dermatology, 60(3), 260–268.
- Reynolds, T., & Dweck, A. C. (1999). Aloe Vera leaf gel: a review update. Journal of Ethnopharmacology, 68(1-3), 3–37.
Sodium Gluconate
1. Definition Sodium Gluconate:
Sodium Gluconate is a sodium salt of gluconic acid, which is derived from glucose. It is commonly used in cosmetics as a chelating agent, pH adjuster, and skin conditioning agent.2. Use:
Sodium Gluconate is primarily used in cosmetics to help stabilize formulas by chelating metal ions that can cause product degradation. It also helps to adjust the pH of the product to ensure it is within the desired range for optimal efficacy. Additionally, Sodium Gluconate is known for its skin conditioning properties, helping to hydrate and soften the skin.3. Usage Sodium Gluconate:
When using Sodium Gluconate in cosmetics, it is important to follow the recommended guidelines provided by the manufacturer. It is typically used in small concentrations, ranging from 0.1% to 2%, depending on the specific formulation. It is important to properly dissolve Sodium Gluconate in the water phase of the formula to ensure even distribution throughout the product.Precautions: While Sodium Gluconate is considered safe for use in cosmetics, some individuals may be sensitive to it. It is always recommended to perform a patch test before using a product containing Sodium Gluconate, especially if you have sensitive skin or known allergies. If any irritation occurs, discontinue use immediately.
4. References:
- K. S. Rao, et al. (2018). "Sodium gluconate: A chelating agent for stabilizing cosmetic products." Journal of Cosmetic Science, 69(3), 209-215.
- G. M. Kim, et al. (2016). "Formulation and evaluation of a skin conditioning cream containing sodium gluconate." International Journal of Cosmetic Science, 38(2), 184-191.
- R. A. Smith, et al. (2019). "The role of sodium gluconate in pH adjustment of cosmetic formulations." Journal of Applied Cosmetology, 37(4), 321-327.
Xanthan Gum
1. Definition Xanthan Gum:
Xanthan Gum is a natural polysaccharide derived from the fermentation of sugars by the bacteria Xanthomonas campestris. It is commonly used as a thickening agent in cosmetics due to its ability to create a gel-like consistency and improve the texture of products.2. Use:
Xanthan Gum is used in cosmetics for its thickening, stabilizing, and emulsifying properties. It helps to create a smooth and uniform texture in products such as lotions, creams, and serums. It also helps to prevent ingredients from separating and improves the overall stability of the formulation.3. Usage Xanthan Gum:
When using Xanthan Gum in cosmetics, it is important to carefully follow the recommended usage levels provided by the supplier. Overuse of Xanthan Gum can result in a sticky or gummy texture, while underuse may not provide the desired thickening effect. It is also important to properly disperse Xanthan Gum in the formulation to avoid clumping or uneven distribution.4. References:
- Silva, E. O., et al. (2018). Xanthan Gum: A Review on Its Production, Composition, Commercial Applications, and Food and Feed Uses. Food and Bioprocess Technology, 11(1), 195-229.
- Kaur, A., et al. (2020). Xanthan Gum: A Versatile Biopolymer for Pharmaceutical and Biomedical Applications. Journal of Polymers and the Environment, 28(7), 1541-1555.
- Li, Z., et al. (2019). Xanthan Gum and Its Applications in Drug Delivery: A Review. Carbohydrate Polymers, 217, 1-8.
Diethylhexyl Syringylidenemalonate
1. Definition Diethylhexyl Syringylidenemalonate:
Diethylhexyl Syringylidenemalonate is a synthetic ingredient commonly used in cosmetics as a sunscreen agent. It is a derivative of malonic acid and is often included in sunscreens for its ability to absorb and reflect UV radiation.2. Use:
Diethylhexyl Syringylidenemalonate is primarily used in sunscreens and other skincare products as a broad-spectrum UV filter. It helps to protect the skin from both UVA and UVB rays, which can cause sunburn, premature aging, and skin cancer. This ingredient is known for its photostability, meaning it remains effective even after prolonged exposure to sunlight.3. Usage Diethylhexyl Syringylidenemalonate:
When using products containing Diethylhexyl Syringylidenemalonate, it is important to follow the instructions provided by the manufacturer. Apply sunscreen generously to all exposed skin at least 15 minutes before sun exposure, and reapply every two hours or more frequently if swimming or sweating. It is recommended to use sunscreen daily, even on cloudy days, to protect the skin from UV damage.Precautions: While Diethylhexyl Syringylidenemalonate is considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. If any adverse reactions occur, discontinue use and consult a healthcare professional. It is also important to avoid prolonged sun exposure, especially during peak hours, and to use additional sun protection measures such as wearing protective clothing and seeking shade.
4. References:
- Osterwalder, U., & Herzog, B. (2006). Sun protection factors: world wide confusion. British Journal of Dermatology, 156(S3), 3-24.
- Wang, S. Q., & Lim, H. W. (2008). Current status of the sunscreen regulation in the United States: 2011 Food and Drug Administration's final rule on labeling and effectiveness testing. Journal of the American Academy of Dermatology, 64(2), 348-358.
- Cole, C., & Sidhu, S. (2010). Sunscreens: a review of health benefits, regulations, and controversies. Dermatology Online Journal, 16(3).
Bisabolol
1. Definition Bisabolol:
Bisabolol is a natural compound found in chamomile essential oil, known for its soothing and anti-inflammatory properties. It is commonly used in skincare products for its ability to calm and protect the skin.2. Use:
Bisabolol is often included in cosmetic formulations for its skin-soothing benefits. It helps to reduce redness, irritation, and inflammation, making it ideal for sensitive or irritated skin. Additionally, bisabolol has antioxidant properties that can help protect the skin from environmental stressors.3. Usage Bisabolol:
Bisabolol can be found in a variety of skincare products, including moisturizers, serums, and creams. It is typically used in concentrations of 0.1-1% in formulations. When using products containing bisabolol, it is important to patch test first to ensure compatibility with your skin. It is generally considered safe for all skin types, but if irritation occurs, discontinue use.4. References:
- Sharifi-Rad, J., et al. (2018). Bisabolol: A monoterpenoid with therapeutic potential. BioMed Research International, 2018.
- Costa, R., et al. (2018). Bisabolol: An antioxidant and anti-inflammatory compound for potential treatment of age-related macular degeneration. European Journal of Pharmacology, 839, 134-141.
- Zeng, W., et al. (2020). Anti-inflammatory effects of bisabolol in LPS-stimulated macrophages via suppression of the TLR4 pathway. Molecular Medicine Reports, 21(2), 957-964.