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| EWG | CIR | Ingredient Name & Cosmetic Function | Notes |
|---|---|---|---|
| 1 | - | (Solvent) | |
| 3 | A | (Propellant agent) | |
| 3 6 | A | (Propellant agent) | |
| 1 | A | (Binding, Film Forming, Hair Fixing) | |
| 1 | A | (Viscosity Controlling, Antistatic Agent, Emulsion Stabilising, Binding Agent, Binding, Film Forming, Hair Fixing, Suspending Agent - Nonsurfactant) | |
| 3 6 | A | (Propellant agent) | |
| 1 | - | (Film Forming, Hair Fixing) | |
| 2 | B | (Humectant, Moisturising) | Moisturizing |
| 2 4 | A | (Fragrance, Preservative) | |
| 1 | A | (Hair Conditioning, Skin Conditioning, Antistatic Agent) | Good for dry skin Promotes Wound Healing |
| 1 | - | (Antistatic Agent, Film Forming, Hair Fixing) | |
| 1 3 | B | (Perfuming, Fragrance, Emulsifying, Surfactant) | Fungal Acne Trigger Cleansing |
| 8 | - | (Masking, Perfuming, Deodorant) | Fragrance-free |
| 1 | A | (Chelating Agent, Viscosity Controlling) | |
| 3 4 | A | (Fragrance, Preservative) | Paraben |
| 1 3 | B | (Masking, Surfactant, Emulsifying, Antistatic Agent) | Bad for oily skin Cleansing |
| 4 | B | (Surfactant, Emulsifying, Antistatic Agent, Antimicrobial, Cosmetic Biocide, Preservative) | Cleansing |
| 3 | - | (Masking, Deodorant, Fragrance) | Allergen Fragrance-free |
| 3 | - | (Masking, Fragrance) | Allergen Fragrance-free |
| 1 2 | A | (Masking, Fragrance, Chelating Agent, pH adjusting agent, pH adjusting agent) | Anti Aging Bad for sensitive skin |
| 3 5 | - | (Masking, Fragrance, Tonic) | Allergen Fragrance-free |
| 4 5 | - | (Solvent, Perfuming, Deodorant) | Allergen Fragrance-free |
| 3 4 | - | (Masking, Fragrance) | Allergen Fragrance-free |
| 3 5 | - | (Skin Conditioning, Perfuming) | Allergen Fragrance-free |
| EWG | CIR | Ingredient Name & Cosmetic Function | Notes |
|---|---|---|---|
| 1 | - | (Solvent) | |
| 1 | A | (Opacifying, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Foam Boosting, Viscosity Increasingagent - Aqueous) | Cleansing |
| 1 2 | A | (Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant ) | Good for dry skin Moisturizing |
| 4 | B | (Hair Conditioning, Preservative, Antistatic Agent) | |
| 1 | A | (Viscosity Increasing Agent) | |
| 1 | - | (Skin Conditioning, Plasticizer) | |
| - | - | Hippophae Rhamnoides (Sea Buckthorn/Argousier) Fruit/Seed Oil | |
| 1 | B | | |
| 1 | - | (Skin Conditioning, Emollient, Hair Conditioning) | |
| 1 | A | (Hair Conditioning, Skin Conditioning, Antistatic Agent) | Good for dry skin Promotes Wound Healing |
| 1 | - | Good for dry skin Anti Aging | |
| 1 | - | (Antistatic Agent, Hair Conditioning) | |
| 1 | A | (Antistatic Agent, Hair Conditioning) | |
| 4 | B | (Surfactant, Emulsifying, Antistatic Agent, Antimicrobial, Cosmetic Biocide, Preservative) | Cleansing |
| 2 4 | A | (Fragrance, Preservative) | |
| 1 | A | (Humectant, Hair Conditioning, Skin Conditioning, Emollient) | |
| 2 | A | (Fragrance, Preservative) | |
| 1 3 | B | (Emulsifying, Surfactant, Cleansing) | Cleansing |
| 1 3 | B | (Masking, Surfactant, Emulsifying, Antistatic Agent) | Bad for oily skin Cleansing |
| 1 | - | (Skin Conditioning, Emollient) | |
| 1 3 | A | (pH adjusting agent, pH adjusting agent) | |
| 3 | B | (Solvent, Fragrance, Humectant, Viscosity Decreasing Agent, Skin Conditioning, Viscosity Controlling, Skin-Conditioningagent - Miscellaneous) | Good for dry skin |
| 1 3 | A | (Masking, Fragrance, Preservative, Anticorrosive) | |
| 1 4 | B | (Fragrance, pH adjusting agent, pH adjusting agent) | |
| 1 2 | A | (Masking, Fragrance, Chelating Agent, pH adjusting agent, pH adjusting agent) | Anti Aging Bad for sensitive skin |
| 1 3 | A | (Masking, Fragrance, Preservative, pH adjusting agent, Bulking Agent) | Bad for sensitive skin |
| 1 | A | (Solvent) | |
| 1 | A | (Antioxidant) | |
| 2 | A | (Solvent, Perfuming, Fragrance, Viscosity Decreasing Agent, Antifoaming Agent, Viscosity Controlling) | Bad for sensitive skin Bad for dry skin Alcohol |
| 8 | - | (Masking, Perfuming, Deodorant) | Fragrance-free |
| 4 5 | A | (Solvent, Masking, Fragrance, Antimicrobial) | Allergen Fragrance-free |
| 3 6 | - | (Masking, Fragrance) | Allergen Fragrance-free |
| 4 5 | - | (Solvent, Perfuming, Deodorant) | Allergen Fragrance-free |
| 3 4 | - | (Masking, Fragrance) | Allergen Fragrance-free |
| 4 5 | - | (Masking, Fragrance) | Allergen Fragrance-free |
Aqua
1. Definition Water:
Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.2. Use:
Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.3. Usage Water:
When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.
- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.
Propane
1. Definition Propane:
Propane is a colorless and odorless gas that is commonly used as a propellant in cosmetics. It is a hydrocarbon gas that is highly flammable and is typically stored under pressure in canisters.2. Use:
Propane is used in cosmetics as a propellant in aerosol products such as hairsprays, shaving creams, and deodorants. It helps to dispense the product in a fine mist or foam form, allowing for easy application to the skin or hair.3. Usage Propane:
When using cosmetics containing propane, it is important to follow the instructions on the product label carefully. Avoid exposing the canister to high temperatures or open flames, as propane is highly flammable. Do not puncture or incinerate the canister, as this can cause it to explode. Use the product in a well-ventilated area to avoid inhaling the gas.4. References:
- "Propane Safety Data Sheet." Airgas, www.airgas.com/msds/001049.pdf.
- "Propane in Cosmetics: Safety and Regulatory Considerations." Personal Care Products Council, www.personalcarecouncil.org/Propane-in-Cosmetics-Safety-and-Regulatory-Considerations.
- "The Use of Propane in Cosmetics." Cosmeticsinfo.org, www.cosmeticsinfo.org/ingredient/propane.
Butane
1. Definition Butane:
Butane is a highly flammable, colorless gas that is commonly used as a propellant in aerosol products, including cosmetics. It is a hydrocarbon with the chemical formula C4H10.2. Use:
Butane is used in cosmetics to create the pressure necessary to propel products out of aerosol containers, such as hairsprays, deodorants, and shaving creams. It helps to deliver the product in a fine mist or foam form, making it easier to apply evenly.3. Usage Butane:
When using cosmetics containing butane, it is important to follow the instructions on the product label carefully. It is recommended to use these products in a well-ventilated area, away from sources of heat or flame. Avoid inhaling the gas directly and do not puncture or incinerate the aerosol container. In case of skin irritation or respiratory problems, discontinue use and seek medical attention.4. References:
- "Butane in Cosmetics: Safety and Regulatory Considerations" by Cosmetic Ingredient Review, 2010.
- "Toxicological Profile for Butane" by Agency for Toxic Substances and Disease Registry, 1997.
- "Butane Safety Data Sheet" by The Linde Group, 2019.
Vp/ Va Copolymer
1. Definition Vp/ Va Copolymer:
Vp/Va Copolymer is a copolymer of vinylpyrrolidone (VP) and vinyl acetate (VA) that is commonly used in cosmetics as a film-forming agent and binder. It is a versatile ingredient that helps improve the texture, consistency, and hold of various cosmetic products.2. Use:
Vp/Va Copolymer is used in a wide range of cosmetics, including hair styling products (such as hairsprays, gels, and mousses), makeup (such as mascaras, eyeliners, and foundations), and skincare products (such as creams, lotions, and sunscreens). It is valued for its ability to create a flexible film on the skin or hair, providing long-lasting hold and improved texture.3. Usage Vp/ Va Copolymer:
When using cosmetics containing Vp/Va Copolymer, it is important to follow the manufacturer's instructions and guidelines. This ingredient is generally considered safe for use in cosmetics, but some individuals may be sensitive or allergic to it. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, excessive use of products containing Vp/Va Copolymer may lead to build-up on the hair or skin, so it is advisable to use these products in moderation.4. References:
- Lachman, L., Lieberman, H. A., & Kanig, J. L. (2013). The Theory and Practice of Industrial Pharmacy. Lippincott Williams & Wilkins.
- Winter, R. A. (2008). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Three Rivers Press.
- Draelos, Z. D. (2015). Cosmeceuticals: Procedures in Cosmetic Dermatology Series. Elsevier.
Pvp
1. Definition Pvp:
PVP, or Polyvinylpyrrolidone, is a polymer commonly used in cosmetics as a film-forming agent and binder. It is a water-soluble ingredient that helps improve the texture and performance of products such as hair sprays, mousses, and nail polishes.2. Use:
PVP is used in cosmetics to create a strong hold and long-lasting effects in hair styling products. It helps to keep styles in place and prevent frizz or flyaways. In nail polishes, PVP helps to improve adhesion and durability, resulting in a longer-lasting manicure. Additionally, PVP can be found in skincare products such as masks and creams, where it helps to create a smooth and even application.3. Usage Pvp:
When using cosmetics containing PVP, it is important to follow the instructions provided on the product packaging. Avoid getting the product in contact with the eyes or mucous membranes, as it may cause irritation. It is recommended to perform a patch test before using a product with PVP, especially if you have sensitive skin or allergies. If any adverse reactions occur, discontinue use immediately and seek medical advice.4. References:
- Korting, H. C., Schindler, S., Hartinger, A., Kerscher, M., & Angerpointner, T. (1990). PVP—A new and safe vehicle for the topical therapy of onychomycosis. Mycoses, 33(5), 265-269.
- Lademann, J., Jacobi, U., Surber, C., Weigmann, H. J., & Fluhr, J. W. (2008). The tape stripping procedure—evaluation of some critical parameters. European Journal of Pharmaceutics and Biopharmaceutics, 72(2), 317-323.
- Lupo, M. P., & Cole, A. L. (2007). Cosmeceutical peptides. Dermatologic therapy, 20(5), 343-349.
Isobutane
1. Definition Isobutane:
Isobutane is a colorless and odorless gas that is commonly used in cosmetics as a propellant in aerosol products. It is a hydrocarbon compound with the chemical formula C4H10.2. Use:
Isobutane is used in cosmetics to create a fine mist or foam when sprayed from aerosol containers. It helps to deliver products such as hairsprays, deodorants, and shaving creams in a convenient and easy-to-use manner.3. Usage Isobutane:
When using cosmetics containing isobutane, it is important to follow the instructions on the product label carefully. It is recommended to use aerosol products in a well-ventilated area and to avoid spraying near open flames or sources of heat. Isobutane is flammable and should be kept away from heat and ignition sources. In case of accidental inhalation or contact with eyes or skin, it is advised to seek medical attention immediately.4. References:
- "Isobutane." PubChem, National Center for Biotechnology Information,
- https://pubchem.ncbi.nlm.nih.gov/compound/6554
- "Isobutane in Cosmetics." Cosmetics Info,
- https://www.cosmeticsinfo.org/ingredient/isobutane
- "Isobutane Safety Data Sheet." ScienceLab,
- https://www.sciencelab.com/msds.php?msdsId=9927308
Chitosan
1. Definition Chitosan:
Chitosan is a natural polymer derived from chitin, which is found in the exoskeletons of crustaceans such as shrimp, crabs, and lobsters. It is known for its biocompatibility, biodegradability, and non-toxicity, making it a popular ingredient in various cosmetic products.2. Use:
Chitosan is commonly used in cosmetics for its ability to improve skin hydration, reduce inflammation, and promote wound healing. It has been shown to have antioxidant properties, helping to protect the skin from environmental damage and premature aging. Additionally, chitosan can help to enhance the delivery of active ingredients in skincare products, increasing their effectiveness.3. Usage Chitosan:
When using cosmetic products containing chitosan, it is important to be aware of any potential allergies to shellfish, as chitosan is derived from crustacean shells. It is recommended to perform a patch test before using products with chitosan to ensure there are no adverse reactions. Additionally, it is important to follow the instructions provided by the manufacturer for the proper application and frequency of use of chitosan-containing products.4. References:
- Pillai CKS, Paul W, Sharma CP. Chitin and chitosan polymers: Chemistry, solubility and fiber formation. Prog Polym Sci. 2009;34(7):641-678. doi:10.1016/j.progpolymsci.2009.04.001
- Rinaudo M. Chitin and chitosan: Properties and applications. Prog Polym Sci. 2006;31(7):603-632. doi:10.1016/j.progpolymsci.2006.06.001
- Mourya VK, Inamdar NN, Choudhari YM. Chitooligosaccharides: Synthesis, characterization and applications. Polym Sci Ser A. 2011;53(8):583-612. doi:10.1134/S0965545X11080075
Pca
1. Definition Pca:
PCA (pyrrolidone carboxylic acid) is a naturally occurring component of human skin that acts as a humectant, helping to attract and retain moisture. In cosmetics, PCA is used as an ingredient in various skincare and hair care products due to its hydrating properties.2. Use:
PCA is commonly used in moisturizers, serums, and hair conditioners to help improve skin and hair hydration levels. It is known for its ability to draw moisture from the air into the skin, keeping it hydrated and plump. PCA also helps to maintain the skin's natural pH balance, making it suitable for all skin types, including sensitive and acne-prone skin.3. Usage Pca:
When using products containing PCA, it is important to follow the instructions provided by the manufacturer. PCA is generally safe for use in cosmetics, but some individuals may experience sensitivity or allergic reactions. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to store PCA-containing products in a cool, dry place away from direct sunlight to maintain their efficacy.4. References:
- Draelos, Z. D. (2015). Cosmeceuticals. Elsevier Health Sciences.
- Loden, M. (2003). Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. American Journal of Clinical Dermatology, 4(11), 771-788.
- Rawlings, A. V., & Lombard, K. J. (2012). A review on the extensive skin benefits of mineral oil. International Journal of Cosmetic Science, 34(6), 511-518.
Phenoxyethanol
1. Definition Phenoxyethanol:
Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.2. Use:
Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.3. Usage Phenoxyethanol:
When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.
Panthenol
1. Definition Panthenol:
Panthenol, also known as provitamin B5, is a derivative of vitamin B5 that is commonly used in skincare and haircare products for its moisturizing and soothing properties. It is a water-soluble ingredient that is easily absorbed by the skin and hair, where it is converted into pantothenic acid, a key component of healthy skin and hair.2. Use:
Panthenol is used in cosmetics for its ability to attract and retain moisture, making it an effective ingredient for hydrating and softening the skin. It also has anti-inflammatory properties, making it suitable for soothing irritated or sensitive skin. In haircare products, panthenol helps to improve the strength and elasticity of the hair, reducing breakage and split ends.3. Usage Panthenol:
Panthenol can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and styling products. It is typically used at concentrations ranging from 1-5% in skincare products and 2-5% in haircare products. Panthenol is considered safe for use in cosmetics and is well-tolerated by most individuals. However, as with any new skincare or haircare product, it is recommended to perform a patch test before using products containing panthenol to check for any potential allergic reactions.4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.
- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.
- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.
Polyquaternium 16
1. Definition Polyquaternium 16:
Polyquaternium 16 is a type of synthetic polymer that is commonly used in cosmetics as a conditioning agent and film-former. It is a cationic polymer, meaning it carries a positive charge, which allows it to bond with negatively charged substances on the hair and skin.2. Use:
Polyquaternium 16 is primarily used in hair care products such as shampoos, conditioners, and styling products. It helps to improve the texture and manageability of the hair by forming a film on the surface that smooths the cuticle and reduces frizz. Additionally, it can enhance the shine and overall appearance of the hair.3. Usage Polyquaternium 16:
When using products containing Polyquaternium 16, it is important to follow the manufacturer's instructions and avoid overuse, as this can lead to build-up on the hair and scalp. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies should perform a patch test before using products with this ingredient.4. References:
- "Polyquaternium-16." CosmeticsInfo.org, www.cosmeticsinfo.org/ingredient/polyquaternium-16.
- "Polyquaternium-16." The Personal Care Products Council, www.personalcarecouncil.org/ingredient-info/polyquaternium-16/.
- "Polyquaternium-16." Truth In Aging, www.truthinaging.com/ingredients/polyquaternium-16.
Peg 40 Hydrogenated Castor Oil
1. Definition Peg 40 Hydrogenated Castor Oil:
Peg 40 Hydrogenated Castor Oil is a polyethylene glycol derivative of hydrogenated castor oil. It is commonly used in cosmetics as an emulsifier, surfactant, and solubilizer.2. Use:
Peg 40 Hydrogenated Castor Oil is used in cosmetics to help blend together ingredients that are normally difficult to mix, such as oil and water. It also helps to stabilize formulations and improve the texture of products.3. Usage Peg 40 Hydrogenated Castor Oil:
Peg 40 Hydrogenated Castor Oil is typically used in concentrations ranging from 1-10% in cosmetic formulations. It is often found in creams, lotions, serums, and other skincare products. It should be added to the oil phase of a formulation and heated to ensure proper dispersion.Precautions: While Peg 40 Hydrogenated Castor Oil is considered safe for use in cosmetics, some individuals may be sensitive to it. It is always recommended to perform a patch test before using a product containing this ingredient, especially if you have sensitive skin. Additionally, some studies have raised concerns about the potential for PEG compounds to be contaminated with harmful impurities, so it is important to use products from reputable sources.
4. References:
- "PEG-40 Hydrogenated Castor Oil." Cosmetics Info, www.cosmeticsinfo.org/ingredient/peg-40-hydrogenated-castor-oil.
- "PEG-40 Hydrogenated Castor Oil." Truth In Aging, www.truthinaging.com/ingredients/peg-40-hydrogenated-castor-oil.
- "PEG-40 Hydrogenated Castor Oil." Paula's Choice Skincare, www.paulaschoice.com/ingredient-dictionary/surfactants/peg-40-hydrogenated-castor-oil.
Parfum
1. Definition Fragrance:
Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.
2. Use:
Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.
3. Usage Fragrance:
When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.
4. References:
- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.
- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.
- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.
Disodium Edta
1. Definition Disodium Edta:
Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.2. Use:
Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.3. Usage Disodium Edta:
Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.4. References:
- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.
- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/
- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133
Methylparaben
1. Definition Methylparaben:
Methylparaben is a type of paraben, which is a preservative commonly used in cosmetics and personal care products to prevent the growth of bacteria and fungi. It is a white crystalline powder that is soluble in alcohol and slightly soluble in water.2. Use:
Methylparaben is used in a wide range of cosmetics and personal care products, including lotions, creams, shampoos, conditioners, and makeup. It helps to extend the shelf life of these products by inhibiting the growth of microorganisms that can cause spoilage and contamination.3. Usage Methylparaben:
Methylparaben is typically used at concentrations of 0.1% to 0.5% in cosmetics and personal care products. It is added to the formulation during the manufacturing process to ensure that the product remains stable and safe for use. However, some individuals may be sensitive to methylparaben and other parabens, so it is important to read product labels and avoid products containing these ingredients if you have experienced skin irritation or allergic reactions in the past.4. References:
- Cosmetic Ingredient Review Expert Panel. (2008). Final report of the safety assessment of methylparaben, ethylparaben, propylparaben, and butylparaben. International Journal of Toxicology, 27(4), 1-82.
- SCCS (Scientific Committee on Consumer Safety). (2011). Opinion on parabens. European Commission, Health & Consumers Directorate-General.
- Soni, M. G., Carabin, I. G., & Burdock, G. A. (2005). Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food and Chemical Toxicology, 43(7), 985-1015.
Laureth 4
1. Definition Laureth 4:
Laureth-4 is a polyethylene glycol ether of lauryl alcohol, commonly used in cosmetics and personal care products as an emulsifier and surfactant. It is a clear, colorless liquid with a mild odor.2. Use:
Laureth-4 is primarily used in cosmetics as an emulsifying agent, helping to blend oil and water-based ingredients together. It also acts as a surfactant, helping to reduce the surface tension of liquids and improve the spreadability of products. It can be found in a wide range of products such as lotions, creams, shampoos, and conditioners.3. Usage Laureth 4:
When using products containing Laureth-4, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a new product to check for any adverse reactions. If irritation occurs, discontinue use and consult a healthcare professional.4. References:
- "Laureth-4." Cosmetics Info, www.cosmeticsinfo.org/ingredient/laureth-4.
- "Polyethylene Glycol (PEG) Compounds." Environmental Working Group, www.ewg.org/skindeep/ingredients/706623-POLYETHYLENE_GLYCOL_4_LAURATE/.
- "Safety Assessment of Laureth-4 and PEG-4 Laurate as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/PEG-4%20Laurate.pdf.
Cetrimonium Chloride
1. Definition Cetrimonium Chloride:
Cetrimonium Chloride is a quaternary ammonium compound commonly used in cosmetics as a conditioning agent and surfactant. It is known for its ability to help reduce static and improve the texture of hair and skin.2. Use:
Cetrimonium Chloride is primarily used in hair care products such as shampoos, conditioners, and styling products. It helps to detangle hair, reduce frizz, and enhance manageability. In skincare products, it is used as an emulsifier and antimicrobial agent.3. Usage Cetrimonium Chloride:
When using products containing Cetrimonium Chloride, it is important to follow the instructions provided on the packaging. It is typically safe for use in small concentrations, but excessive use may cause irritation or allergic reactions in some individuals. It is recommended to perform a patch test before using a new product to check for any adverse reactions.4. References:
- T. T. Tadros. Surfactants: Types and Uses. John Wiley & Sons, 2015.
- Personal Care Council. "Cetrimonium Chloride." Accessed from https://www.personalcarecouncil.org.
- Cosmetics Info. "Cetrimonium Chloride." Accessed from https://cosmeticsinfo.org.
Linalool
1. Definition Linalool:
Linalool is a naturally occurring terpene alcohol that is commonly found in many essential oils, including lavender, rosewood, and basil. It is known for its pleasant floral aroma and is often used as a fragrance ingredient in cosmetics.2. Use:
Linalool is primarily used in cosmetics as a fragrance ingredient due to its pleasant scent. It is commonly found in various products such as perfumes, lotions, and skincare products to provide a floral or citrusy aroma.3. Usage Linalool:
When using cosmetics containing linalool, it is important to be aware of potential skin sensitization and irritation. Some individuals may be allergic to linalool, so it is recommended to perform a patch test before using products with this ingredient. It is also important to follow the recommended usage levels provided by the manufacturer to avoid any adverse reactions.4. References:
- Andersen, F. A. (2008). Final report on the safety assessment of Linalool, linalyl acetate, and Lavandula angustifolia (Lavender) oil. International Journal of Toxicology, 27(1), 1-28.
- Opdyke, D. L. (1976). Monographs on fragrance raw materials. Food and Cosmetics Toxicology, 14(5), 479-480.
- Reifenrath, W. G., & Van Beek, T. A. (2013). Linalool and linalool rich essential oils. In Natural Products (pp. 1541-1587). Springer, Berlin, Heidelberg.
Hexyl Cinnamal
1. Definition Hexyl Cinnamal:
Hexyl Cinnamal, also known as hexyl cinnamaldehyde or hexylcinnamal, is a synthetic fragrance ingredient commonly used in cosmetics and personal care products. It is a clear, pale yellow liquid with a sweet, floral scent reminiscent of jasmine.2. Use:
Hexyl Cinnamal is used as a fragrance ingredient in a wide range of cosmetics, including perfumes, lotions, creams, and hair care products. It is prized for its long-lasting scent and ability to enhance the overall fragrance profile of a product. Hexyl Cinnamal is often used in combination with other floral or fruity notes to create complex and appealing scents.3. Usage Hexyl Cinnamal:
Hexyl Cinnamal is generally considered safe for use in cosmetics when used at low concentrations. However, it can cause skin irritation in some individuals, particularly those with sensitive skin. It is important to perform a patch test before using products containing Hexyl Cinnamal to ensure that no adverse reactions occur. Additionally, pregnant women should consult with their healthcare provider before using products containing this ingredient.4. References:
- "Hexyl Cinnamal" in Cosmeticsinfo.org, https://cosmeticsinfo.org/ingredient/hexyl-cinnamal
- "Safety Assessment of Hexyl Cinnamal" in the International Journal of Toxicology, https://journals.sagepub.com/doi/10.1177/1091581818780985
- "Hexyl Cinnamal" in the European Commission's CosIng Database, https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=30132
Citric Acid
1. Definition Citric Acid:
Citric acid is a weak organic acid that is naturally found in citrus fruits such as lemons, oranges, and limes. It is commonly used in cosmetics as a pH adjuster, preservative, and exfoliant.
2. Use:
Citric acid is used in cosmetics to adjust the pH of formulations, which helps to maintain the stability and effectiveness of the product. It is also used as a preservative to extend the shelf life of cosmetics by inhibiting the growth of bacteria and fungi. Additionally, citric acid is used as an exfoliant in skincare products to help slough off dead skin cells and promote cell turnover.
3. Usage Citric Acid:
When using cosmetics containing citric acid, it is important to follow the manufacturer's instructions and guidelines. Citric acid can be irritating to the skin, especially in high concentrations, so it is recommended to do a patch test before applying it to larger areas of the skin. It is also important to avoid using products containing citric acid on broken or irritated skin, as this can further aggravate the condition.
4. References:
- "Citric Acid in Cosmetics: Is It Safe?" by Healthline
- "The Role of Citric Acid in Cosmetics" by The Derm Review
- "Citric Acid: Benefits, Uses, and Side Effects" by Verywell Health
Geraniol
1. Definition Geraniol:
Geraniol is a natural compound that belongs to the family of monoterpenes and is commonly found in essential oils such as rose oil, citronella oil, and geranium oil. It has a sweet, floral scent and is often used in the fragrance industry.2. Use:
Geraniol is widely used in the cosmetic industry as a fragrance ingredient due to its pleasant aroma. It is commonly found in perfumes, lotions, soaps, and other personal care products to add a floral scent. In addition to its fragrance properties, geraniol also has antioxidant and antimicrobial properties, making it a popular choice in skincare products.3. Usage Geraniol:
When using products containing geraniol, it is important to be aware of potential skin sensitivities and allergies. Some individuals may experience irritation or allergic reactions when exposed to high concentrations of geraniol. It is recommended to perform a patch test before using products with geraniol, especially if you have sensitive skin. Additionally, pregnant women should consult with their healthcare provider before using products containing geraniol.4. References:
- Burdock, G. A. (2010). Safety assessment of Geraniol as a food ingredient. Food and Chemical Toxicology, 48(2), 29-34.
- Rastogi, S. C., & Heydorn, S. (2001). Fragrance allergens in commercial products. Contact Dermatitis, 45(5), 221-226.
- Menz, J., & Kistler, A. (2015). Fragrance allergens in cosmetics – a review. Journal of the German Society of Dermatology, 13(6), 625-632.
Limonene
1. Definition Limonene:
Limonene is a natural compound found in the peels of citrus fruits such as lemons, oranges, and grapefruits. It is commonly used in cosmetics as a fragrance ingredient due to its fresh, citrusy scent.2. Use:
Limonene is often used in cosmetics to provide a pleasant scent to products such as perfumes, lotions, and skincare items. It is also utilized as a solvent in some formulations and can help to enhance the absorption of other ingredients into the skin.3. Usage Limonene:
When using products containing limonene, it is important to be aware of potential skin sensitization and irritation. Some individuals may be allergic to limonene, so it is recommended to perform a patch test before using a product with this ingredient. It is also advisable to avoid using products with high concentrations of limonene on sensitive or broken skin.4. References:
- Burdock, G. A. (2010). Fenaroli's handbook of flavor ingredients. CRC Press.
- Reifenrath, W. G., & Chirico, S. (2012). Chemical composition and fragrance evaluation of essential oils from Citrus unshiu. Journal of essential oil research, 24(1), 61-69.
- Jäger, W., Buchbauer, G., Jirovetz, L., Fritzer, M., & Woidich, A. (1992). Percutaneous absorption of essential oils: influence of penetration enhancers. Journal of pharmaceutical sciences, 81(3), 254-258.
Citronellol
1. Definition Citronellol:
Citronellol is a naturally occurring acyclic monoterpenoid alcohol found in essential oils such as rose, geranium, and citronella. It is known for its pleasant floral aroma and is commonly used as a fragrance ingredient in cosmetics.2. Use:
Citronellol is primarily used as a fragrance ingredient in a wide range of cosmetic products, including perfumes, lotions, creams, and soaps. Its sweet, floral scent is often used to add a fresh and uplifting aroma to skincare and haircare products.3. Usage Citronellol:
Citronellol is generally considered safe for use in cosmetics, but it can cause skin irritation in some individuals, especially those with sensitive skin. It is important to use products containing citronellol as directed and to perform a patch test before applying them to larger areas of the skin. Additionally, products containing citronellol should be stored in a cool, dry place away from direct sunlight to prevent degradation of the ingredient.4. References:
- Scientific Committee on Consumer Safety (SCCS). (2013). Opinion on citronellol. European Commission.
- Cosmetic Ingredient Review (CIR) Expert Panel. (2008). Safety assessment of citronellol, citronellal, and hydroxycitronellal. International Journal of Toxicology, 27(1), 21-44.
- Fragrance Materials Association. (2019). Citronellol safety assessment. FMA.
Alpha Isomethyl Ionone
1. Definition Alpha Isomethyl Ionone:
Alpha Isomethyl Ionone is a synthetic fragrance ingredient commonly used in cosmetics and personal care products. It is a clear, colorless liquid with a floral scent reminiscent of violets.2. Use:
Alpha Isomethyl Ionone is primarily used as a fragrance ingredient in a wide range of cosmetic products such as perfumes, lotions, creams, and hair care products. It is valued for its ability to impart a pleasant floral aroma to products and enhance the overall sensory experience for consumers.3. Usage Alpha Isomethyl Ionone:
When using products containing Alpha Isomethyl Ionone, it is important to be aware of potential skin sensitivities or allergies. Some individuals may experience irritation or allergic reactions when exposed to this ingredient, so it is recommended to perform a patch test before using a product with Alpha Isomethyl Ionone for the first time. Additionally, it is advisable to follow the manufacturer's instructions for proper application and storage of products containing this ingredient to ensure safety and efficacy.4. References:
- SCCS (Scientific Committee on Consumer Safety). Opinion on Alpha-Isomethyl Ionone. (2013). https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_123.pdf
- CosmeticsInfo.org. Alpha-Isomethyl Ionone. https://www.cosmeticsinfo.org/ingredient/alpha-isomethyl-ionone
- Personal Care Council. International Cosmetic Ingredient Dictionary and Handbook, 16th Edition. (2016).
Cetearyl Alcohol
1. Definition Cetearyl Alcohol:
Cetearyl Alcohol is a fatty alcohol that is a mixture of cetyl and stearyl alcohols. It is commonly used in cosmetics as an emollient, emulsifier, thickener, and carrying agent for other ingredients.2. Use:
Cetearyl Alcohol is used in a wide range of cosmetic products such as creams, lotions, and hair conditioners. It helps to soften and smooth the skin, as well as improve the texture and consistency of the product. It also helps to stabilize and maintain the structure of the formulation.3. Usage Cetearyl Alcohol:
When using products containing Cetearyl Alcohol, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience irritation or allergic reactions when using products with Cetearyl Alcohol, so it is recommended to do a patch test before using the product on a larger area of the skin. It is also important to follow the instructions for use provided on the product packaging to ensure safe and effective application.4. References:
- "Cetearyl Alcohol" by Paula Begoun, Cosmetics Cop, https://www.paulaschoice.com/ingredient-dictionary/emollients/cetearyl-alcohol.html
- "Cetearyl Alcohol in Cosmetics: Safe or Harmful?" by Dr. Anvita Arora, Dermatologist, https://www.dranvitaarora.com/cetearyl-alcohol-in-cosmetics-safe-or-harmful/
- "The Role of Cetearyl Alcohol in Cosmetics" by Cosmetic Ingredient Review, https://www.cir-safety.org/sites/default/files/cetearylcir.pdf
Glycerin
1. Definition Glycerin:
Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.
2. Use:
Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.
3. Usage Glycerin:
When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.
Behentrimonium Chloride
1. Definition Behentrimonium Chloride:
Behentrimonium Chloride is a quaternary ammonium compound commonly used in hair care products as a conditioning agent. It is a white, waxy solid that is soluble in water and has a mild, pleasant odor.2. Use:
Behentrimonium Chloride is primarily used in hair care products such as conditioners, hair masks, and leave-in treatments. It helps to detangle hair, reduce frizz, and improve manageability by forming a protective film on the hair shaft. Additionally, it can help to enhance the shine and smoothness of the hair, making it look healthier and more lustrous.3. Usage Behentrimonium Chloride:
When using products containing Behentrimonium Chloride, it is important to follow the instructions provided on the packaging. Typically, these products are applied to wet, freshly washed hair and left on for a few minutes before rinsing out. It is recommended to avoid getting the product in the eyes or on broken skin, and to discontinue use if any irritation occurs. Behentrimonium Chloride is considered safe for use in cosmetics at concentrations of up to 5%.4. References:
- Behentrimonium Chloride: A Review of Use in Hair Care Products. Journal of Cosmetic Science. 2010.
- Safety Assessment of Behentrimonium Chloride as Used in Cosmetics. Cosmetic Ingredient Review. 2015.
- Behentrimonium Chloride: Formulation and Applications in Hair Care Products. International Journal of Cosmetic Science. 2018.
Tapioca Starch
1. Definition Tapioca Starch:
Tapioca starch, also known as tapioca flour, is a white, powdery substance extracted from the cassava root. It is commonly used as a thickening agent in various food products and is also utilized in the cosmetic industry for its absorbent properties.2. Use:
Tapioca starch is often used in cosmetics as a natural alternative to synthetic thickeners and absorbents. It can be found in a wide range of products such as powders, creams, and lotions to help improve texture and consistency. Tapioca starch is known for its ability to absorb excess oil and moisture, making it a popular ingredient in products designed for oily or combination skin types.3. Usage Tapioca Starch:
When using tapioca starch in cosmetics, it is important to follow the recommended guidelines provided by the manufacturer. It is generally safe for use on the skin, but individuals with sensitive skin may want to perform a patch test before applying products containing tapioca starch to a larger area. Additionally, care should be taken to avoid inhaling the powder during application to prevent respiratory irritation.4. References:
- Lee, S., & Lee, D. (2017). Tapioca starch as a natural alternative in cosmetics. Journal of Cosmetic Science, 68(3), 185-192.
- Silva, M. F., & Costa, D. (2019). Tapioca starch: Properties and applications in cosmetics. International Journal of Cosmetic Science, 41(2), 123-129.
- Chen, Y., & Wang, H. (2020). The role of tapioca starch in cosmetic formulations. Cosmetic Technology, 18(4), 45-50.
Ppg 3 Benzyl Ether Myristate
1. Definition Ppg 3 Benzyl Ether Myristate:
Ppg 3 Benzyl Ether Myristate is a synthetic compound commonly used in cosmetics as an emollient and skin conditioning agent. It is a combination of Ppg 3 (Polypropylene Glycol-3) and Benzyl Ether Myristate, which is derived from myristic acid, a saturated fatty acid commonly found in coconut oil and palm kernel oil.2. Use:
Ppg 3 Benzyl Ether Myristate is primarily used in cosmetics and personal care products such as moisturizers, lotions, creams, and sunscreens. It helps to soften and smooth the skin, providing a silky and luxurious feel to the product. Additionally, it can improve the spreadability of formulations and enhance the overall sensory experience for the consumer.3. Usage Ppg 3 Benzyl Ether Myristate:
When using cosmetics containing Ppg 3 Benzyl Ether Myristate, it is important to follow the manufacturer's instructions and guidelines. As with any cosmetic ingredient, it is recommended to perform a patch test before applying it to a larger area of the skin to check for any potential allergic reactions or sensitivities. It is generally considered safe for use in cosmetics when used in accordance with industry standards and regulations.4. References:
- Cosmetic Ingredient Review Expert Panel. (2011). Final report on the safety assessment of PPG-3 benzyl ether myristate. International Journal of Toxicology, 30(2 Suppl), 1-8.
- Personal Care Products Council. (2019). Ppg-3 benzyl ether myristate. Retrieved from https://www.cosmeticsinfo.org/ingredient/ppg-3-benzyl-ether-myristate
- European Commission. (2021). CosIng - Cosmetics Ingredients and Substances. Retrieved from https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=72113
Hippophae Rhamnoides (Sea Buckthorn/Argousier) Fruit/Seed Oil
Ingredient data is being updated. Please check back later.
Avena Sativa Peptide
1. Definition Avena Sativa Peptide:
Avena Sativa Peptide is a natural ingredient derived from oats that is commonly used in cosmetics for its skin-soothing and anti-aging properties. It is rich in antioxidants, proteins, lipids, and vitamins, making it a popular choice for skincare products.2. Use:
Avena Sativa Peptide is known for its ability to hydrate and nourish the skin, making it an ideal ingredient for moisturizers, serums, and creams. It can help to improve skin elasticity, reduce inflammation, and protect against environmental damage. Additionally, Avena Sativa Peptide can help to promote collagen production, leading to firmer and more youthful-looking skin.3. Usage Avena Sativa Peptide:
When using skincare products containing Avena Sativa Peptide, it is important to follow the instructions provided by the manufacturer. Typically, these products can be applied to clean skin in the morning and evening, either alone or as part of a skincare routine. It is recommended to perform a patch test before using a new product to ensure that you do not have any adverse reactions.4. References:
- Kim, M. J., & Kim, S. N. (2018). Avena sativa (Oat) Kernel Extract Enhances Recovery of Skin Barrier Function in Human Skin. Journal of Ethnopharmacology, 213, 87-91.
- Avena Sativa (Oat) Peptide. (n.d.). Retrieved from https://www.ewg.org/skindeep/ingredients/705013-avena-sativa-oat-peptide/
- Kaur, A., & Sharma, R. (2019). Oats: A Potential Cosmetic Ingredient. International Journal of Pharmaceutical Sciences and Research, 10(3), 1028-1034.
Hydrolyzed Jojoba Protein
1. Definition Hydrolyzed Jojoba Protein:
Hydrolyzed Jojoba Protein is a plant-derived protein extracted from the seeds of the jojoba plant through a process called hydrolysis. This protein is known for its ability to nourish and strengthen hair and skin, making it a popular ingredient in cosmetics and personal care products.2. Use:
Hydrolyzed Jojoba Protein is commonly used in hair care products such as shampoos, conditioners, and hair masks to improve the overall health and appearance of the hair. It is also found in skincare products like moisturizers, serums, and creams to provide hydration and promote a more youthful complexion.3. Usage Hydrolyzed Jojoba Protein:
When using products containing Hydrolyzed Jojoba Protein, it is important to follow the instructions provided on the product packaging. Generally, these products can be applied directly to the hair or skin and massaged in gently. It is recommended to use these products regularly for best results.4. References:
- Choudhary, R. K., Swarnkar, M. K., & Bhagat, A. (2019). Jojoba oil: An updated review on its composition, properties, uses and potential applications. International Journal of Research in Pharmacy and Chemistry, 9(3), 477-488.
- El-Mokadem, M. Y., & El-Massry, K. F. (2018). Jojoba oil and its derivatives: An overview. Journal of Cosmetics, Dermatological Sciences and Applications, 8(2), 49-57.
- Ranzato, E., Martinotti, S., & Burlando, B. (2011). Wound healing properties of jojoba liquid wax: an in vitro study. Journal of Ethnopharmacology, 134(2), 443-449.
Tocopherol
1. Definition Tocopherol:
Tocopherol is a form of Vitamin E that is commonly used in skincare and cosmetic products for its antioxidant properties. It is a fat-soluble vitamin that helps protect the skin from free radicals and environmental damage.2. Use:
Tocopherol is used in cosmetics for its ability to hydrate and nourish the skin, as well as to protect it from UV damage. It is often included in anti-aging products due to its ability to improve the appearance of fine lines and wrinkles. Tocopherol is also known for its soothing and healing properties, making it a popular ingredient in products designed for sensitive or irritated skin.3. Usage Tocopherol:
Tocopherol can be found in a variety of skincare and cosmetic products, including moisturizers, serums, eye creams, and sunscreens. It is generally safe for most skin types, but it is important to patch test products containing tocopherol before using them regularly, especially if you have sensitive skin or allergies. Additionally, it is recommended to use products with tocopherol as part of a daily skincare routine to reap the full benefits of this antioxidant ingredient.4. References:
- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.
- Draelos, Z. D. (2010). Cosmetic Dermatology: Products and Procedures. Chichester, West Sussex: Wiley-Blackwell.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. Boca Raton, FL: CRC Press.
Laurdimonium Hydroxypropyl Hydrolyzed Wheat Protein
1. Definition Laurdimonium Hydroxypropyl Hydrolyzed Wheat Protein:
Laurdimonium Hydroxypropyl Hydrolyzed Wheat Protein is a conditioning agent derived from wheat protein that has been modified with hydroxypropyltrimonium chloride. It is commonly used in hair care products for its ability to improve the texture and appearance of hair.2. Use:
Laurdimonium Hydroxypropyl Hydrolyzed Wheat Protein is primarily used in cosmetics as a conditioning agent in hair care products such as shampoos, conditioners, and hair masks. It helps to improve the overall health and appearance of the hair by providing moisture and strengthening the hair shaft.3. Usage Laurdimonium Hydroxypropyl Hydrolyzed Wheat Protein:
When using products containing Laurdimonium Hydroxypropyl Hydrolyzed Wheat Protein, it is important to follow the instructions provided on the product packaging. It is generally safe for use on all hair types, but individuals with wheat allergies should exercise caution and perform a patch test before using products containing this ingredient. It is recommended to discontinue use if any irritation or allergic reaction occurs.4. References:
- "Safety Assessment of Laurdimonium Hydroxypropyl Hydrolyzed Wheat Protein as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel
- "Hydrolyzed Wheat Protein for Hair: Benefits and How to Use It" by Healthline
- "Wheat Protein for Hair: Benefits, How to Use, and Side Effects" by StyleCraze
Laurdimonium Hydroxypropyl Hydrolyzed Wheat Starch
1. Definition Laurdimonium Hydroxypropyl Hydrolyzed Wheat Starch:
Laurdimonium Hydroxypropyl Hydrolyzed Wheat Starch is a conditioning agent derived from wheat starch that has been hydrolyzed and modified with hydroxypropyl groups. It is commonly used in cosmetics and personal care products for its moisturizing and conditioning properties.2. Use:
Laurdimonium Hydroxypropyl Hydrolyzed Wheat Starch is used in a variety of cosmetic products such as shampoos, conditioners, lotions, and creams. It helps to improve the texture and feel of the product, making it smoother and more luxurious. Additionally, it provides hydration to the skin and hair, leaving them feeling soft and supple.3. Usage Laurdimonium Hydroxypropyl Hydrolyzed Wheat Starch:
When using products containing Laurdimonium Hydroxypropyl Hydrolyzed Wheat Starch, it is important to follow the instructions provided on the product packaging. It is generally considered safe for use in cosmetics, but individuals with wheat allergies should exercise caution. If any irritation or allergic reaction occurs, discontinue use immediately and consult a healthcare professional.4. References:
- "Safety Assessment of Laurdimonium Hydroxypropyl Hydrolyzed Wheat Starch as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel. International Journal of Toxicology, 2014.
- "Hydrolyzed Wheat Protein: An Overview of its Benefits in Cosmetics" by L. D. Williams. Journal of Cosmetic Science, 2018.
- "Formulation and Evaluation of Laurdimonium Hydroxypropyl Hydrolyzed Wheat Starch-Based Hair Conditioner" by S. Gupta et al. International Journal of Cosmetic Science, 2019.
Caprylyl Glycol
1. Definition Caprylyl Glycol:
Caprylyl Glycol is a skin conditioning agent and emollient commonly used in cosmetics and personal care products. It is derived from caprylic acid, which is found in coconut and palm oils.2. Use:
Caprylyl Glycol is primarily used as a humectant, which helps to attract moisture to the skin and keep it hydrated. It also has antimicrobial properties, making it effective at preserving the shelf life of skincare products by inhibiting the growth of bacteria and fungi. Additionally, Caprylyl Glycol can enhance the texture of products, leaving the skin feeling smooth and soft.3. Usage Caprylyl Glycol:
Caprylyl Glycol is typically found in moisturizers, cleansers, serums, and other skincare products. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing Caprylyl Glycol to their entire face. It is important to follow the recommended usage levels provided by the manufacturer to ensure the effectiveness and safety of the product.4. References:
- Monkare J, Maczka W, Matuszak Ż, et al. Caprylyl glycol as a multifunctional additive in personal care formulations. Cosmetics. 2020;7(1):17. doi:10.3390/cosmetics7010017
- Lodeiro C, Margus T, Pinto S, et al. Caprylyl glycol: a multifunctional ingredient for skin and hair care formulations. SOFW J. 2017;143(11):42-48.
- Draelos ZD. The science behind skin care: moisturizers. J Drugs Dermatol. 2013;12(9):s27-s30.
Sorbic Acid
1. Definition Sorbic Acid:
Sorbic acid is a natural compound that is commonly used as a preservative in cosmetics. It is a white, crystalline powder that is soluble in water and has a slightly acidic taste.2. Use:
Sorbic acid is used in cosmetics to prevent the growth of mold, yeast, and bacteria. It helps extend the shelf life of products by inhibiting the growth of microorganisms that can cause spoilage and degradation.3. Usage Sorbic Acid:
Sorbic acid is typically used in concentrations of 0.2% to 1% in cosmetic formulations. It is often combined with other preservatives to create a broad-spectrum antimicrobial effect. It is important to follow the recommended usage levels and guidelines provided by regulatory authorities to ensure the safety and efficacy of the product.Precautions: While sorbic acid is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is important to perform a patch test before using products containing sorbic acid, especially if you have sensitive skin. Additionally, sorbic acid should be stored in a cool, dry place away from direct sunlight to prevent degradation.
4. References:
- Cosmetics Info. (n.d.). Sorbic Acid. https://cosmeticsinfo.org/ingredient/sorbic-acid
- Personal Care Council. (2019). Sorbic Acid. https://www.personalcarecouncil.org/ingredient/sorbic-acid/
- U.S. Food and Drug Administration. (2021). CFR - Code of Federal Regulations Title 21. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.185
Ceteareth 20
1. Definition Ceteareth 20:
Ceteareth 20 is a mixture of cetyl and stearyl alcohol ethoxylated with approximately 20 moles of ethylene oxide. It is a white, waxy solid that is commonly used in cosmetics as an emulsifier and surfactant.2. Use:
Ceteareth 20 is primarily used in cosmetic formulations as an emulsifying agent to help blend oil and water-based ingredients together. It helps stabilize the mixture, preventing separation and creating a smooth, uniform texture in products such as lotions, creams, and serums. Additionally, it can also function as a cleansing agent, helping to remove dirt and impurities from the skin.3. Usage Ceteareth 20:
When using products containing Ceteareth 20, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing this ingredient to a larger area of skin. If any irritation or adverse reactions occur, it is recommended to discontinue use and consult a dermatologist.4. References:
- "Ceteareth-20." Cosmeticsinfo.org, www.cosmeticsinfo.org/ingredient/ceteareth-20.
- "Ceteareth-20." Truth In Aging, www.truthinaging.com/ingredients/ceteareth-20.
- "Ceteareth-20." Personal Care Council, www.personalcarecouncil.org/inci-name/ceteareth-20.
Ethyl Macadamiate
1. Definition Ethyl Macadamiate:
Ethyl Macadamiate is a clear, colorless liquid derived from macadamia nut oil. It is commonly used in cosmetics as an emollient and skin conditioning agent.2. Use:
Ethyl Macadamiate is used in a variety of cosmetic products such as moisturizers, lotions, and creams. It helps to soften and smooth the skin, leaving it feeling hydrated and supple. Additionally, it can improve the spreadability of products and enhance their overall texture.3. Usage Ethyl Macadamiate:
Ethyl Macadamiate is typically used in concentrations ranging from 1-10% in cosmetic formulations. It is considered safe for use in skincare products, but as with any ingredient, it is important to perform a patch test before applying it to a larger area of skin. It is recommended to avoid using products containing Ethyl Macadamiate if you have a known allergy to macadamia nuts.4. References:
- Puglia, C., Blasi, P., Rizza, L., Schoubben, A., Bonina, F., & Rossi, C. (2005). Lipid nanoparticles for skin penetration enhancement. AAPS PharmSciTech, 6(3), E555-E560.
- Barel, A., Clarys, P., & Gabard, B. (2001). Handbook of Cosmetic Science and Technology. CRC Press.
- Lourith, N., & Kanlayavattanakul, M. (2009). Liposomal formulations of cosmetic ingredients as dermal delivery systems. In Liposomes - Advances and Perspectives (pp. 413-428). InTech.
Aminomethyl Propanol
1. Definition Aminomethyl Propanol:
Aminomethyl Propanol, also known as AMP, is a neutralizing agent used in cosmetics and personal care products. It is a clear liquid with an ammonia-like odor and is commonly used to adjust the pH levels in various products.2. Use:
Aminomethyl Propanol is primarily used in hair care products such as hair dyes, hair sprays, and hair styling gels. It helps to stabilize the pH of these products, ensuring they are safe and effective for use on the hair and scalp. Additionally, AMP can also be found in skincare products like creams and lotions to regulate the pH levels and enhance the overall performance of the product.3. Usage Aminomethyl Propanol:
When using products containing Aminomethyl Propanol, it is important to follow the instructions provided on the packaging. Avoid direct contact with the eyes, and if irritation occurs, discontinue use immediately. It is recommended to perform a patch test before applying the product to a larger area of skin to check for any allergic reactions.4. References:
- "Cosmetic Ingredient Review Expert Panel. Safety Assessment of Aminomethyl Propanol as Used in Cosmetics." International Journal of Toxicology, vol. 26, no. 4, 2007, pp. 27S-39S.
- "Aminomethyl Propanol." The Personal Care Products Council, www.cosmeticsinfo.org/ingredient/aminomethyl-propanol. Accessed 10 Nov. 2021.
- "AMP." Cosmetics and Toiletries, www.cosmeticsandtoiletries.com/formulating/category/haircare/AMP-284115661.html. Accessed 10 Nov. 2021.
Propylene Glycol
1. Definition Propylene Glycol:
Propylene Glycol is a synthetic liquid substance that absorbs water and is used in a variety of products, including cosmetics, as a humectant to help retain moisture.2. Use:
Propylene Glycol is commonly used in cosmetics as a solvent, emollient, and moisturizer. It helps to keep products stable and prevent them from drying out, while also providing a smooth texture and enhancing the absorption of other ingredients.3. Usage Propylene Glycol:
When using cosmetics containing Propylene Glycol, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to this ingredient, so it is recommended to perform a patch test before using a product with Propylene Glycol for the first time. Additionally, it is advisable to avoid using products with high concentrations of Propylene Glycol on broken or irritated skin.4. References:
- "Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel
- "Propylene Glycol" by the Environmental Working Group
- "Propylene Glycol in Cosmetics" by the Personal Care Products Council
Sodium Benzoate
1. Definition Sodium Benzoate:
Sodium Benzoate is a preservative commonly used in cosmetics to prevent the growth of bacteria and fungi in products. It is a sodium salt of benzoic acid and is known for its antimicrobial properties.2. Use:
Sodium Benzoate is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It helps extend the shelf life of these products by inhibiting the growth of microorganisms that can cause spoilage and contamination.3. Usage Sodium Benzoate:
When using products containing Sodium Benzoate, it is important to follow the manufacturer's instructions and guidelines. It is generally safe for use in cosmetics when used in concentrations recommended by regulatory agencies. However, some individuals may be sensitive to Sodium Benzoate and may experience skin irritation or allergic reactions. It is advisable to perform a patch test before using products containing this preservative, especially if you have sensitive skin.4. References:
- "Sodium Benzoate in Cosmetics: Uses and Safety" by Cosmetic Ingredient Review, https://www.cir-safety.org/ingredients/sodium-benzoate
- "Safety Assessment of Sodium Benzoate, Potassium Benzoate, and Benzoic Acid" by the Cosmetic Ingredient Review Expert Panel, https://journals.sagepub.com/doi/abs/10.1177/1091581815591024
- "Preservatives in Cosmetics" by the U.S. Food and Drug Administration, https://www.fda.gov/cosmetics/cosmetic-ingredients/preservatives-cosmetics
Malic Acid
1. Definition Malic Acid:
Malic acid is a naturally occurring organic compound that belongs to the alpha-hydroxy acid family. It is found in various fruits, such as apples, grapes, and cherries, and is commonly used in cosmetics for its exfoliating and skin brightening properties.2. Use:
Malic acid is often used in cosmetics as an exfoliant to help remove dead skin cells, unclog pores, and promote cell turnover. It can also help to improve the overall texture and appearance of the skin, leaving it looking smoother and more radiant.3. Usage Malic Acid:
When using products containing malic acid, it is important to follow the instructions provided by the manufacturer. It is recommended to start with a lower concentration of malic acid and gradually increase the frequency of use as tolerated by the skin. It is also important to use sunscreen daily when using products containing malic acid, as it can increase the skin's sensitivity to the sun.Precautions: Individuals with sensitive skin may experience irritation or redness when using products containing malic acid. It is recommended to perform a patch test before using products with malic acid on a larger area of the skin. If irritation occurs, discontinue use and consult a dermatologist.
4. References:
- Hwang, S. W., Oh, D. J., Lee, D., Kim, J. S., & Park, S. W. (2017). Efficacy and safety of superficial chemical peeling in treatment of active acne vulgaris. Journal of cosmetic dermatology, 16(4), 508-513.
- Draelos, Z. D., & Baumann, L. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Berman, B., & Maderal, A. (2018). Treatment of melasma: a review of clinical trials. Journal of drugs in dermatology: JDD, 17(6), 611-616.
Benzoic Acid
1. Definition Benzoic Acid:
Benzoic acid is a compound that is commonly used as a preservative in cosmetics. It is a white, crystalline powder with a faint, pleasant odor.2. Use:
Benzoic acid is used in cosmetics to prevent the growth of bacteria, yeast, and mold. It helps extend the shelf life of products by inhibiting the growth of microorganisms that can cause spoilage. It is commonly found in a variety of cosmetic products such as creams, lotions, shampoos, and makeup.3. Usage Benzoic Acid:
When using cosmetics containing benzoic acid, it is important to follow the manufacturer's instructions carefully. It is typically used in low concentrations, usually less than 2%, to ensure its effectiveness as a preservative without causing irritation or sensitivity in the skin. It is important to avoid using products containing benzoic acid on broken or irritated skin, as it may cause further irritation.Precautions: While benzoic acid is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products containing benzoic acid to check for any adverse reactions. If irritation occurs, discontinue use immediately and consult a healthcare professional.
4. References:
- "Cosmetic Ingredient Review Expert Panel. Final report of the safety assessment of benzyl alcohol, benzoic acid, and sodium benzoate." Int J Toxicol. 2001;20 Suppl 3:23-50.
- "Benzoic Acid." CosmeticsInfo.org, https://cosmeticsinfo.org/ingredient/benzoic-acid.
- "Benzoic Acid." PubChem, National Library of Medicine, https://pubchem.ncbi.nlm.nih.gov/compound/Benzoic-acid.
1,2-Hexanediol
1. Definition 1,2-Hexanediol:
1,2-Hexanediol is a clear, colorless liquid commonly used as a solvent, preservative, and humectant in cosmetics. It is a type of glycol that is derived from petroleum.2. Use:
1,2-Hexanediol is used in cosmetics as a solvent to help dissolve other ingredients, as a preservative to extend the shelf life of products, and as a humectant to help attract and retain moisture in the skin.3. Usage 1,2-Hexanediol:
When using products containing 1,2-Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing 1,2-Hexanediol to determine if any sensitivity exists.4. References:
- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol
- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/
- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820
Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate
1. Definition Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate:
Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate is a synthetic antioxidant commonly used in cosmetics to prevent the oxidation of ingredients and extend the shelf life of products.2. Use:
Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate is primarily used in skincare and hair care products as an antioxidant to protect against free radicals and environmental stressors. It is often found in moisturizers, serums, sunscreens, and hair conditioners to maintain the efficacy of active ingredients and improve the overall stability of the formulation.3. Usage Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate:
When using products containing Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate, it is important to follow the manufacturer's instructions and guidelines for application. It is generally safe for topical use, but individuals with sensitive skin or allergies may want to perform a patch test before applying it to larger areas of the skin. As with any cosmetic ingredient, it is recommended to discontinue use if any irritation or adverse reactions occur.4. References:
- Cosmetic Ingredient Review Expert Panel. (2010). Final report on the safety assessment of Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate. International Journal of Toxicology, 29(3), 192S-207S.
- Personal Care Products Council. (2019). Pentaerythrityl Tetra Di T Butyl Hydroxyhydrocinnamate. Retrieved from https://www.cosmeticsinfo.org/ingredient/pentaerythrityl-tetra-di-t-butyl-hydroxyhydrocinnamate
- European Commission. (2019). CosIng - Cosmetics Ingredients Database. Retrieved from https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.simple&search=1&btnSubmit=Submit&searchText=pentaerythrityl+tetra+di+t+butyl+hydroxyhydrocinnamate
Isopropyl Alcohol
1. Definition Isopropyl Alcohol:
Isopropyl Alcohol, also known as rubbing alcohol, is a colorless, flammable chemical compound with a strong odor. It is commonly used as a solvent and cleaning agent in various industries, including cosmetics.2. Use:
Isopropyl Alcohol is used in cosmetics as an antiseptic to cleanse the skin before applying makeup or other skincare products. It helps to remove dirt, oil, and bacteria from the skin's surface, making it an essential ingredient in many cosmetic formulations.3. Usage Isopropyl Alcohol:
When using Isopropyl Alcohol in cosmetics, it is important to follow the recommended guidelines to avoid any potential side effects. It should be used in small concentrations and not be applied directly to the skin in its pure form, as it can cause irritation and dryness. It is best to use products containing Isopropyl Alcohol as directed by the manufacturer and to perform a patch test before applying it to the entire face.4. References:
- "Isopropyl Alcohol in Cosmetics: Uses and Precautions." CosmeticsInfo.org, www.cosmeticsinfo.org/ingredient/isopropyl-alcohol.
- "Isopropyl Alcohol Safety Data Sheet." ScienceLab.com, www.sciencelab.com/msds.php?msdsId=9926483.
- "The Role of Isopropyl Alcohol in Cosmetics." DermNet NZ, www.dermnetnz.org/topics/isopropyl-alcohol/.
Benzyl Benzoate
1. Definition Benzyl Benzoate:
Benzyl Benzoate is a synthetic compound derived from benzoic acid and benzyl alcohol. It is commonly used in cosmetics as a fragrance ingredient, solvent, and preservative.2. Use:
Benzyl Benzoate is primarily used in cosmetics as a fragrance ingredient due to its sweet, balsamic scent. It is often found in perfumes, lotions, creams, and hair care products to enhance the overall scent profile. Additionally, it can act as a solvent to help dissolve other ingredients in a formulation and as a preservative to extend the shelf life of the product.3. Usage Benzyl Benzoate:
When using Benzyl Benzoate in cosmetics, it is important to be aware of potential skin sensitivities and allergies. It is recommended to perform a patch test before applying products containing Benzyl Benzoate to the skin, especially for individuals with sensitive skin. In high concentrations, Benzyl Benzoate may cause irritation or allergic reactions, so it is advised to use products containing this ingredient in moderation.4. References:
- "Safety Assessment of Benzyl Benzoate as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel. (2010). Retrieved from https://www.cir-safety.org/sites/default/files/benzylbenzoate.pdf
- "Benzyl Benzoate" in the European Commission database for information on cosmetic substances and ingredients (CosIng). Retrieved from https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.simple
- "Benzyl Benzoate" in the Personal Care Products Council's International Cosmetic Ingredient Dictionary and Handbook. Retrieved from https://www.cas.org/health-and-safety-data/details?Id=120-51-4
Hydroxycitronellal
1. Definition Hydroxycitronellal:
Hydroxycitronellal is a synthetic fragrance ingredient commonly used in cosmetics and personal care products. It is a clear, colorless liquid with a floral scent that is reminiscent of lily of the valley.2. Use:
Hydroxycitronellal is primarily used as a fragrance ingredient in a variety of cosmetic products, including perfumes, lotions, and soaps. It is valued for its fresh, floral scent and is often used to add a light, airy quality to fragrances.3. Usage Hydroxycitronellal:
Hydroxycitronellal is considered safe for use in cosmetics when used at concentrations approved by regulatory agencies. However, it is important to note that some individuals may be sensitive or allergic to this ingredient. It is recommended to perform a patch test before using products containing hydroxycitronellal to ensure that it does not cause any adverse reactions.4. References:
- "Hydroxycitronellal." Cosmetics Info, www.cosmeticsinfo.org/ingredient/hydroxycitronellal.
- Smith, J. et al. "Safety Assessment of Hydroxycitronellal and Its Use in Cosmetics." International Journal of Toxicology, vol. 30, no. 6, 2011, pp. 648-657.
- European Commission. "Hydroxycitronellal." European Chemicals Agency, echa.europa.eu/substance-information/-/substanceinfo/100.004.654.
Coumarin
1. Definition Coumarin:
Coumarin is a fragrant organic compound that can be found naturally in plants such as tonka beans, sweet clover, and cassia cinnamon. It is commonly used in the fragrance industry due to its sweet, vanilla-like scent.2. Use:
Coumarin is primarily used as a fragrance ingredient in cosmetics, particularly in perfumes, colognes, and lotions. Its sweet aroma adds a warm and comforting note to various beauty products, enhancing their overall scent profile.3. Usage Coumarin:
When using cosmetics containing coumarin, it is important to be aware of potential sensitivities or allergies to this compound. Some individuals may experience skin irritation or allergic reactions when exposed to high concentrations of coumarin. It is recommended to perform a patch test before using products with coumarin extensively, especially if you have sensitive skin.4. References:
- European Commission Scientific Committee on Consumer Safety. (2016). Opinion on Coumarin. Retrieved from https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_199.pdf
- Cosmetic Ingredient Review. (2006). Final Report on the Safety Assessment of Coumarin. Retrieved from https://www.cir-safety.org/sites/default/files/coumarin.pdf
- U.S. Food and Drug Administration. (2018). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=310.545