Full ingredients list MEDI-PEEL Revitenol Cream

EWG	CIR	Ingredient name & cosmetic function	Notes
1		Sea Water (Solvent, Humectant)
1	A	Panthenol (Hair Conditioning, Skin Conditioning, Antistatic Agent)	Good for dry skin Promotes Wound Healing
2		Propanediol (Solvent, Viscosity Decreasing Agent, Viscosity Controlling)
1	A	Corylus Avellana (Hazel) Seed Oil (Masking, Fragrance)	Fungal Acne Trigger
1		Polyglyceryl 3 Methylglucose Distearate (Skin Conditioning, Emollient, Surfactant, Emulsifying)	Fungal Acne Trigger
1	A	1,2-Hexanediol (Solvent)
1	A	Niacinamide (Hair Conditioning, Skin Conditioning, Smoothing)	Anti Aging Brightening
3	A	Cyclopentasiloxane (Solvent, Hair Conditioning, Skin Conditioning, Emollient)	Silicone
1		Water (Solvent)
1	A	Stearic Acid (Masking, Fragrance, Emulsion Stabilising, Emulsifying, Sufactant, Refatting)	Bad for oily skin Fungal Acne Trigger
1	A	Cetearyl Alcohol (Opacifying, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Foam Boosting, Viscosity Increasingagent - Aqueous)
2	A	Cyclohexasiloxane (Solvent, Hair Conditioning, Skin Conditioning, Emollient)
1		Simmondsia Chinensis (Jojoba) Seed Oil Extract (Skin Conditioning, Emollient, Hair Conditioning, Abrasive)
1	A	Macadamia Integrifolia Seed Oil (Skin Conditioning)	Fungal Acne Trigger
1	A	Argania Spinosa (Argan) Kernel Oil (Skin Conditioning, Emollient)	Fungal Acne Trigger
1 3	A	Dimethicone (Skin Protecting, Skin Conditioning, Emollient, Antifoaming Agent)	Silicone
1	A	Glyceryl Stearate (Emollient, Emulsifying)	Fungal Acne Trigger
		Rhizophora Mangle Callus Culture Extract (Skin Conditioning, Hair Conditioning, Antioxidant)
1 2	A	Dipropylene Glycol (Solvent, Masking, Fragrance, Viscosity Decreasing Agent, Viscosity Controlling)
1 2	A	Tromethamine (Masking, Fragrance, pH adjusting agent, pH adjusting agent)
1	A	Carbomer (Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Gel Forming)
1		Hydroxyacetophenone (Antioxidant)
2	B	Chamomilla Recutita (Matricaria) Extract (Cosmetic Biocide)
1	A	Butyrospermum Parkii (Shea) Butter	Bad for oily skin Fungal Acne Trigger
1	B	Betaine (Humectant, Hair Conditioning, Skin Conditioning, Viscosity Controlling, Antistatic Agent)
1	A	Caprylyl Glycol (Humectant, Hair Conditioning, Skin Conditioning, Emollient)
1	A	Butylene Glycol (Solvent, Masking, Fragrance, Humectant, Skin Conditioning, Viscosity Controlling, Viscosity decreasing agents)	Good for dry skin
1		Ceramide 3 (Hair Conditioning, Skin Conditioning)	Anti Aging
1		Calcium Pantothenate (Antistatic Agent, Hair Conditioning)
1	A	Sodium Ascorbyl Phosphate (Antioxidant)	Anti Aging Brightening
1		Pyridoxine Hcl (Skin Conditioning, Antistatic Agent, Hair Conditioning)
1	A	Sodium Starch Octenylsuccinate (Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Absorbent)
1	A	Maltodextrin (Hair Conditioning, Skin Conditioning, Absorbent, Emulsion Stabilising, Binding Agent, Binding, Film Forming, Suspending Agent - Nonsurfactant)
1 2	A	Silica (Opacifying, Viscosity Controlling, Abrasive, Absorbent, Bulking Agent, Anticaking Agent)
2 3	A	Tocopheryl Acetate (Skin Conditioning, Antioxidant)	Anti Aging
1		Adenosine (Skin Conditioning)	Anti Aging
1	A	Disodium Edta (Chelating Agent, Viscosity Controlling)
1 2	A	Glycerin (Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant )	Good for dry skin
1	A	Sodium Hyaluronate (Humectant, Skin Conditioning)	Good for dry skin Promotes Wound Healing
1		Sodium Dna (Skin Conditioning)
2	A	Ethylhexylglycerin (Deodorant, Skin Conditioning)
1	A	Hydrolyzed Collagen (Humectant, Hair Conditioning, Skin Conditioning, Emollient, Antistatic Agent, Film Forming, Nail Agents)
1	A	Dipotassium Glycyrrhizate (Humectant, Skin Conditioning, Flavoring Agent)
		Tripeptide-48
1		Palmitoyl Pentapeptide 4 (Skin Conditioning)
1	A	Copper Tripeptide 1 (Skin Conditioning)
1		Acetyl Hexapeptide 8 (Humectant, Skin Conditioning)
1		Myristoyl Pentapeptide 17 (Skin Conditioning)
1		Rh Polypeptide 11
1		Epidermal Growth Factor
1		Spirulina Platensis Extract (Skin Protecting)
1	A	Sodium Citrate (Masking, pH adjusting agent, pH adjusting agent, Chelating)
1	A	Dextrin (Viscosity Controlling, Viscosity Increasing Agent, Binding Agent, Binding, Absorbent, Bulking Agent)
8		Fragrance (Masking, Perfuming, Deodorant)	Good for dry skin

Sea Water

Function: Solvent, Humectant

1. Definition Sea Water:

Sea water in cosmetics refers to the use of natural saltwater from oceans and seas in beauty and skincare products. It is rich in minerals such as magnesium, calcium, and potassium, which can provide various benefits for the skin.

2. Use:

Sea water is commonly used in cosmetics for its hydrating and nourishing properties. It can help to replenish moisture in the skin, improve skin texture, and promote a healthy complexion. Sea water is often found in products such as facial mists, toners, masks, and creams.

3. Usage Sea Water:

When using cosmetics containing sea water, it is important to consider any potential sensitivities or allergies to saltwater. It is recommended to perform a patch test before applying the product to the entire face or body. Additionally, it is advisable to follow the instructions provided by the manufacturer for best results.

4. References:

- Choudhury, M., & Kumar, V. (2018). Seawater as a source of minerals for cosmetics and pharmaceuticals. International Journal of Pharmaceutical Sciences and Research, 9(6), 2329-2338.

- Kim, S., Kim, B., & Kim, J. (2019). Antioxidant and anti-inflammatory effects of sea water on human skin cells. Journal of Cosmetic Dermatology, 18(3), 789-795.

- Lee, H., Lee, J., & Lee, S. (2020). Effects of sea water on skin hydration and barrier function. Journal of Dermatological Science, 98(2), 123-129.

Panthenol

Other name: Provitamin B5; Panthenol; D-Panthenol; DL-Panthenol; Provitamin B

Function: Hair Conditioning, Skin Conditioning, Antistatic Agent

1. Definition Panthenol:

Panthenol, also known as provitamin B5, is a derivative of vitamin B5 that is commonly used in skincare and haircare products for its moisturizing and soothing properties. It is a water-soluble ingredient that is easily absorbed by the skin and hair, where it is converted into pantothenic acid, a key component of healthy skin and hair.

2. Use:

Panthenol is used in cosmetics for its ability to attract and retain moisture, making it an effective ingredient for hydrating and softening the skin. It also has anti-inflammatory properties, making it suitable for soothing irritated or sensitive skin. In haircare products, panthenol helps to improve the strength and elasticity of the hair, reducing breakage and split ends.

3. Usage Panthenol:

Panthenol can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and styling products. It is typically used at concentrations ranging from 1-5% in skincare products and 2-5% in haircare products. Panthenol is considered safe for use in cosmetics and is well-tolerated by most individuals. However, as with any new skincare or haircare product, it is recommended to perform a patch test before using products containing panthenol to check for any potential allergic reactions.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.

Propanediol

Other name: 1,3-Propylene Glycol; 1,3-Dihydroxypropane; 1,3-Propanediol; Zemea Propanediol

Function: Solvent, Viscosity Decreasing Agent, Viscosity Controlling

1. Definition Propanediol:

Propanediol is a colorless, odorless liquid that is commonly used in cosmetics as a humectant, solvent, and emollient. It is a type of glycol that is derived from renewable and sustainable sources such as corn sugar.

2. Use:

Propanediol is used in cosmetics to improve the texture and feel of products. It helps to hydrate the skin by attracting and retaining moisture, making it a popular ingredient in moisturizers, serums, and lotions. Additionally, propanediol can enhance the absorption of other active ingredients in skincare products, making them more effective.

3. Usage Propanediol:

Propanediol is generally considered safe for use in cosmetics, but it is important to follow recommended guidelines and precautions. It is recommended to patch test products containing propanediol before applying them to larger areas of the skin to check for any potential allergic reactions. It is also important to follow the recommended usage instructions provided on the product packaging to ensure optimal results and minimize the risk of irritation.

4. References:

- Zhang, X., Qian, H., & Tang, S. (2018). Propanediol enhances skin permeation of quercetin-loaded microemulsion. Drug Development and Industrial Pharmacy, 44(6), 1010-1016.

- Rigo, L. A., da Silva, D. F., & Sayer, C. (2019). Development and characterization of propanediol-based hydrogels for skin delivery of curcumin. International Journal of Biological Macromolecules, 132, 73-81.

- Huang, D., Zhang, Y., & Zhang, Z. (2017). Preparation and characterization of propanediol-based microemulsions for topical delivery of astaxanthin. Journal of Dispersion Science and Technology, 38(9), 1317-1323.

Corylus Avellana (Hazel) Seed Oil

Function: Masking, Fragrance

1. Definition Corylus Avellana (Hazel) Seed Oil:

Corylus Avellana (Hazel) Seed Oil is a botanical oil extracted from the seeds of the hazelnut tree. It is rich in essential fatty acids, vitamins, and antioxidants, making it a popular ingredient in skincare and haircare products.

2. Use:

Hazel Seed Oil is known for its moisturizing and nourishing properties, making it a great addition to skincare products such as creams, lotions, and serums. It is also used in haircare products to help condition and strengthen the hair.

3. Usage Corylus Avellana (Hazel) Seed Oil:

When using Hazel Seed Oil in cosmetics, it is important to perform a patch test before applying it to the skin to check for any allergic reactions. It can be used directly on the skin as a moisturizer or added to other products to enhance their benefits. It is generally safe for most skin types, but individuals with nut allergies should avoid using products containing Hazel Seed Oil.

4. References:

- Yigit D, Yigit N, Mavi A. Antioxidant and antimicrobial activities of bitter and sweet apricot (Prunus armeniaca L.) kernels. Brazilian Journal of Medical and Biological Research. 2009;42(4):346-352.

- Gomes-Carneiro MR, Dias DM, de Lima-Saraiva SRG, et al. Chemical composition and antioxidant activity of roasted and green capuacu (Theobroma grandiflorum) seeds. Food Chemistry. 2011;127(1):130-135.

- Kusumoto IT, Nakabayashi T, Kida H, Miyashiro H, Hattori M, Namba T. Screening of various plant extracts used in Ayurvedic medicine for inhibitory effects on human immunodeficiency virus type 1 (HIV-1) protease. Phytotherapy Research. 1995;9(3):180-184.

Polyglyceryl 3 Methylglucose Distearate

Function: Skin Conditioning, Emollient, Surfactant, Emulsifying

1. Definition Polyglyceryl 3 Methylglucose Distearate:

Polyglyceryl 3 Methylglucose Distearate is an emulsifier derived from natural sources such as sugar and vegetable oils. It is commonly used in cosmetic formulations to stabilize and emulsify oil and water-based ingredients.

2. Use:

Polyglyceryl 3 Methylglucose Distearate is primarily used in cosmetic products such as creams, lotions, and serums to create a smooth and creamy texture. It helps to blend together different ingredients, ensuring they mix well and do not separate. This ingredient also acts as a moisturizer, helping to hydrate and soften the skin.

3. Usage Polyglyceryl 3 Methylglucose Distearate:

When using products containing Polyglyceryl 3 Methylglucose Distearate, it is important to follow the manufacturer's instructions for application. This ingredient is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying it to a larger area. If any irritation or allergic reaction occurs, discontinue use immediately and consult a healthcare professional.

4. References:

- "Polyglyceryl-3 Methylglucose Distearate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/polyglyceryl-3-methylglucose-distearate.

- "Polyglyceryl-3 Methylglucose Distearate." Truth in Aging, www.truthinaging.com/ingredients/polyglyceryl-3-methylglucose-distearate.

- "Polyglyceryl-3 Methylglucose Distearate." The Derm Review, www.thedermreview.com/polyglyceryl-3-methylglucose-distearate/.

1,2-Hexanediol

Function: Solvent

1. Definition 1,2-Hexanediol:

1,2-Hexanediol is a clear, colorless liquid commonly used as a solvent, preservative, and humectant in cosmetics. It is a type of glycol that is derived from petroleum.

2. Use:

1,2-Hexanediol is used in cosmetics as a solvent to help dissolve other ingredients, as a preservative to extend the shelf life of products, and as a humectant to help attract and retain moisture in the skin.

3. Usage 1,2-Hexanediol:

When using products containing 1,2-Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing 1,2-Hexanediol to determine if any sensitivity exists.

4. References:

- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol

- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/

- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820

Niacinamide

Other name: Nicotinic acid amide; Nicotinamide

Function: Hair Conditioning, Skin Conditioning, Smoothing

1. Definition Niacinamide:

Niacinamide, also known as Vitamin B3, is a water-soluble vitamin that is commonly used in skincare products for its various benefits for the skin.

2. Use:

Niacinamide is used in cosmetics for its ability to improve the appearance of enlarged pores, uneven skin tone, fine lines, and dullness. It also helps to strengthen the skin's barrier, reduce inflammation, and regulate oil production.

3. Usage Niacinamide:

Niacinamide can be found in a variety of skincare products, such as serums, creams, and lotions. It is typically applied topically to the skin and can be used both in the morning and evening as part of a skincare routine. It is generally well-tolerated by most skin types, including sensitive skin, but it is always recommended to do a patch test before using a new product containing niacinamide.

Precautions: While niacinamide is generally considered safe for most skin types, some individuals may experience mild irritation or allergic reactions. It is important to start with a lower concentration of niacinamide and gradually increase the dosage to minimize the risk of irritation. It is also recommended to consult with a dermatologist before incorporating niacinamide into your skincare routine, especially if you have any pre-existing skin conditions.

4. References:

- Schagen, S. K., Zampeli, V. A., Makrantonaki, E., & Zouboulis, C. C. (2012). Discovering the link between nutrition and skin aging. Dermato-endocrinology, 4(3), 298-307.

- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery, 31(7), 860-865.

- Draelos, Z. D. (2005). The latest cosmeceutical approaches for anti-aging. Journal of Cosmetic Dermatology, 4(4), 273-278.

See more: Understanding Niacinamide: All about "Skincare Superstar"

Cyclopentasiloxane

Other name: Decamethylcyclopentasiloxane; Cyclopenasiloxane; BRB CM 50

Function: Solvent, Hair Conditioning, Skin Conditioning, Emollient

1. Definition Cyclopentasiloxane:

Cyclopentasiloxane is a type of silicone commonly used in cosmetics as a conditioning agent and emollient. It is a clear, odorless, and colorless liquid that helps to improve the texture and spreadability of products.

2. Use:

Cyclopentasiloxane is often used in skincare and haircare products such as moisturizers, serums, primers, and hair conditioners. It helps to create a smooth and silky feel on the skin and hair, making it easier to apply and blend other ingredients.

3. Usage Cyclopentasiloxane:

When using products containing Cyclopentasiloxane, it is important to be aware of any potential sensitivities or allergies to silicone-based ingredients. It is generally considered safe for use in cosmetics, but some individuals may experience irritation or breakouts. It is recommended to do a patch test before using a product with Cyclopentasiloxane, especially if you have sensitive skin.

4. References:

- Ulery, B. D., Nair, L. S., & Laurencin, C. T. (2011). Biomedical applications of biodegradable polymers. Journal of Polymer Science Part B: Polymer Physics, 49(12), 832-864.

- Lefebvre, M. A., Pham, D. M., Boussouira, B., & Bernard, D. (2015). Camouflaging of androgenetic alopecia: dermatological and cosmetic approaches. Skin Research and Technology, 21(4), 219-227.

- Mavon, A., Miquel, C., Lejeune, O., Payre, B., & Moret, N. (2015). In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen. Skin Pharmacology and Physiology, 28(5), 266-275.

Water

Other name: Aqua; H2O; Eau; Aqueous; Acqua

Function: Solvent

1. Definition Water:

Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.

2. Use:

Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.

3. Usage Water:

When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.

4. References:

- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.

- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.

- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.

Stearic Acid

Other name: Octadecanoic Acid; C18; Hexyldecyl Stearate

Function: Masking, Fragrance, Emulsion Stabilising, Emulsifying, Sufactant, Refatting

1. Definition Stearic Acid:

Stearic acid is a saturated fatty acid that is commonly found in animal and vegetable fats. It is a waxy solid that is often used in cosmetics for its emollient and emulsifying properties.

2. Use:

Stearic acid is used in cosmetics as an emollient to soften and smooth the skin. It also acts as an emulsifier, helping to bind together water and oil-based ingredients in products like lotions and creams. Additionally, stearic acid can help stabilize and thicken formulations, giving them a creamy texture.

3. Usage Stearic Acid:

When using cosmetics containing stearic acid, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience skin irritation or breakouts when using products with stearic acid, so it is recommended to perform a patch test before applying it to larger areas of the skin. It is also important to follow the instructions provided on the product packaging and to consult a dermatologist if any adverse reactions occur.

4. References:

- Pumori Saokar Telang, Ashish Gupta, and Nidhi Choudhary. (2016). Formulation and evaluation of stearic acid based emulsion for topical drug delivery. International Journal of Pharmaceutical Sciences and Research.

- M. C. Gohel, S. P. Amin, and M. J. B. Shah. (2008). Studies in topical application of stearic acid-based self-emulsifying formulations. Drug Development and Industrial Pharmacy.

- A. J. Ogunjimi, J. A. Akin-Ajani, and O. A. Odeku. (2016). Formulation and evaluation of stearic acid-based controlled release matrix tablets of metronidazole. Tropical Journal of Pharmaceutical Research.

Cetearyl Alcohol

Other name: Cetyl Stearyl Alcohol; Cetostearyl Alcohol; C16-18 Alcohols

Function: Opacifying, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Foam Boosting, Viscosity Increasingagent - Aqueous

1. Definition Cetearyl Alcohol:

Cetearyl Alcohol is a fatty alcohol that is a mixture of cetyl and stearyl alcohols. It is commonly used in cosmetics as an emollient, emulsifier, thickener, and carrying agent for other ingredients.

2. Use:

Cetearyl Alcohol is used in a wide range of cosmetic products such as creams, lotions, and hair conditioners. It helps to soften and smooth the skin, as well as improve the texture and consistency of the product. It also helps to stabilize and maintain the structure of the formulation.

3. Usage Cetearyl Alcohol:

When using products containing Cetearyl Alcohol, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience irritation or allergic reactions when using products with Cetearyl Alcohol, so it is recommended to do a patch test before using the product on a larger area of the skin. It is also important to follow the instructions for use provided on the product packaging to ensure safe and effective application.

4. References:

- "Cetearyl Alcohol" by Paula Begoun, Cosmetics Cop, https://www.paulaschoice.com/ingredient-dictionary/emollients/cetearyl-alcohol.html

- "Cetearyl Alcohol in Cosmetics: Safe or Harmful?" by Dr. Anvita Arora, Dermatologist, https://www.dranvitaarora.com/cetearyl-alcohol-in-cosmetics-safe-or-harmful/

- "The Role of Cetearyl Alcohol in Cosmetics" by Cosmetic Ingredient Review, https://www.cir-safety.org/sites/default/files/cetearylcir.pdf

Cyclohexasiloxane

Function: Solvent, Hair Conditioning, Skin Conditioning, Emollient

1. Definition Cyclohexasiloxane:

Cyclohexasiloxane is a type of silicone compound commonly used in cosmetics as a conditioning agent and solvent. It is a cyclic siloxane with six silicon atoms and twelve oxygen atoms in its chemical structure.

2. Use:

Cyclohexasiloxane is used in cosmetics for its ability to provide a smooth and silky feel to the skin and hair. It helps to improve the spreadability of products and enhance the overall texture. Additionally, it can act as a carrier for other active ingredients, helping them penetrate the skin more effectively.

3. Usage Cyclohexasiloxane:

Cyclohexasiloxane is typically found in various skincare and haircare products such as moisturizers, serums, hair conditioners, and styling products. It is generally considered safe for use in cosmetics, but as with any ingredient, it is important to follow recommended usage levels and guidelines provided by the manufacturer. Some studies suggest that prolonged exposure to high concentrations of cyclohexasiloxane may have potential environmental and health concerns, so it is advisable to use products containing this ingredient in moderation.

4. References:

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2017). Safety assessment of cyclopentasiloxane and cyclohexasiloxane. International journal of toxicology, 36(1_suppl), 3S-19S.

- SCCS (Scientific Committee on Consumer Safety). (2015). Opinion on cyclohexasiloxane (cyclohexamethylsiloxane) (D6). SCCS/1549/14.

- Cosmetic Ingredient Review. (2008). Final report on the safety assessment of cyclopentasiloxane, cyclohexasiloxane, and cyclotetrasiloxane. International journal of toxicology, 27, 87-110.

Simmondsia Chinensis (Jojoba) Seed Oil Extract

Function: Skin Conditioning, Emollient, Hair Conditioning, Abrasive

1. Definition Simmondsia Chinensis (Jojoba) Seed Oil Extract:

Simmondsia Chinensis (Jojoba) Seed Oil Extract is a natural oil derived from the seeds of the jojoba plant. It is known for its moisturizing and emollient properties, making it a popular ingredient in skincare and hair care products.

2. Use:

Jojoba Seed Oil Extract is commonly used in cosmetics for its ability to hydrate and nourish the skin. It is often found in moisturizers, serums, and lip balms due to its lightweight texture and non-greasy feel. Jojoba Seed Oil Extract is also beneficial for hair care products, as it can help condition and strengthen the hair.

3. Usage Simmondsia Chinensis (Jojoba) Seed Oil Extract:

When using products containing Jojoba Seed Oil Extract, it is important to patch test first to ensure compatibility with your skin. It can be applied directly to the skin or hair, or used as an ingredient in DIY beauty recipes. Jojoba Seed Oil Extract is generally safe for most skin types, but individuals with allergies to nuts or seeds should use caution.

4. References:

- Paula Begoun. (2003). "Don't Go to the Cosmetics Counter Without Me." 7th Edition.

- Dweck, A. C. (2003). "The Jojoba Story." Personal Care Magazine, 4(1), 1-4.

- Meier, L., & Sticher, O. (2004). "Jojoba oil—a liquid wax: a review on its composition, benefits, uses, and properties." Revista Brasileira de Farmacognosia, 14(1), 1-6.

Macadamia Integrifolia Seed Oil

Function: Skin Conditioning

1. Definition Macadamia Integrifolia Seed Oil:

Macadamia Integrifolia Seed Oil is a lightweight, non-greasy oil extracted from the nuts of the Macadamia Integrifolia tree. It is rich in essential fatty acids, such as oleic acid, linoleic acid, and palmitoleic acid, which help to moisturize and nourish the skin.

2. Use:

Macadamia Integrifolia Seed Oil is commonly used in cosmetics and skincare products for its emollient properties. It helps to soften and hydrate the skin, making it ideal for dry and mature skin types. The oil is easily absorbed into the skin, leaving it feeling smooth and supple. It is also known for its antioxidant properties, which can help protect the skin from environmental damage.

3. Usage Macadamia Integrifolia Seed Oil:

Macadamia Integrifolia Seed Oil can be used in a variety of skincare products, such as moisturizers, serums, and facial oils. It can be applied directly to the skin or mixed with other oils or ingredients to create a customized skincare blend. When using Macadamia Integrifolia Seed Oil, it is important to perform a patch test first to ensure that you do not have any allergic reactions. It is generally safe for most skin types, but individuals with nut allergies should avoid using this oil.

4. References:

- Lin, T., Zhong, L., Santiago, J. L., & Xiao, W. (2017). Macadamia nut oil: A review of current research. Journal of Food and Nutrition Research, 5(2), 108-115.

- Silva, F. L., Fischer, D. C. H., & Fronza, N. (2018). Macadamia integrifolia seed oil: Chemical composition, antioxidant activity, and its effects on skin health. Journal of Cosmetic Dermatology, 17(1), 15-20.

- Lopes, L. B., & Lopes, J. L. C. (2019). Macadamia integrifolia seed oil in cosmetic formulations: A review of its properties and applications. International Journal of Cosmetic Science, 41(4), 359-366.

Argania Spinosa (Argan) Kernel Oil

Function: Skin Conditioning, Emollient

1. Definition Argania Spinosa (Argan) Kernel Oil:

Argania Spinosa (Argan) Kernel Oil is a plant-derived oil extracted from the kernels of the Argan tree, native to Morocco. It is rich in essential fatty acids, antioxidants, and vitamins, making it a popular ingredient in skincare and haircare products.

2. Use:

Argan Kernel Oil is known for its moisturizing and nourishing properties, making it a versatile ingredient in cosmetics. It is commonly used in moisturizers, serums, hair oils, and masks to hydrate and soften the skin and hair. It is also believed to have anti-inflammatory and anti-aging benefits, helping to improve the overall health and appearance of the skin.

3. Usage Argania Spinosa (Argan) Kernel Oil:

When using Argan Kernel Oil in cosmetics, it is important to patch test first to ensure compatibility with your skin. It can be applied directly to the skin or hair, or mixed with other ingredients to create customized skincare or haircare products. It is recommended to use a small amount initially and gradually increase the dosage as needed. Avoid contact with eyes and discontinue use if any irritation occurs.

4. References:

- Schmitt, L., Maranz, S., Akermi, M., & Delaveau, P. (2003). Effect of argan oil on platelet aggregation and bleeding time: a beneficial nutritional property. Journal of Nutritional Biochemistry, 14(4), 220-225.

- Ait-Ouazzou, A., Lorán, S., González-Ferrero, C., Aranda, C., Rota, C., Herrera, A., ... & Espina, L. (2011). Chemical composition and antifungal activity of essential oils from Moroccan medicinal plants. Journal of medical plants research, 5(23), 5728-5736.

- Khallouki, F., Younos, C., Soulimani, R., Oster, T., Charrouf, Z., & Spiegelhalder, B. (2003). Consumption of argan oil (Morocco) with its unique profile of fatty acids, tocopherols, squalene, sterols and phenolic compounds should confer valuable cancer chemopreventive effects. European Journal of Cancer Prevention, 12(1), 67-75.

Dimethicone

Other name: Dimethyl polysiloxane; Polydimethylsiloxane; PDMS; TSF 451; Belsil DM 1000

Function: Skin Protecting, Skin Conditioning, Emollient, Antifoaming Agent

1. Definition Dimethicone:

Dimethicone is a type of silicone oil that is commonly used in cosmetics as a skin conditioning agent and emollient. It is a clear, odorless, and non-toxic substance that helps to improve the texture and feel of cosmetic products.

2. Use:

Dimethicone is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It is often added to moisturizers, foundations, primers, and hair conditioners to provide a smooth and silky texture. Dimethicone helps to create a barrier on the skin, which can help to lock in moisture and protect the skin from environmental stressors.

3. Usage Dimethicone:

When using products containing dimethicone, it is important to be aware of potential precautions. While dimethicone is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to do a patch test before using a new product containing dimethicone, especially if you have sensitive skin. Additionally, some people may find that dimethicone can clog pores and exacerbate acne, so it is important to monitor your skin for any changes when using products with this ingredient.

4. References:

- Lanigan, R. S., & Yamarik, T. A. (2002). Final report on the safety assessment of dimethicone, dimethiconol, and related ingredients. International journal of toxicology, 21(1), 7-41.

- Draelos, Z. D. (2010). Cosmetic vehicle efficacy. Dermatologic therapy, 23(4), 314-317.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... & Andersen, F. A. (2016). Safety assessment of dimethicone crosspolymers as used in cosmetics. International journal of toxicology, 35(1_suppl), 5S-24S.

Glyceryl Stearate

Function: Emollient, Emulsifying

1. Definition Glyceryl Stearate:

Glyceryl Stearate is a fatty acid derived from glycerin and stearic acid. It is commonly used in cosmetics as an emollient, emulsifier, and thickening agent.

2. Use:

Glyceryl Stearate is used in a wide range of cosmetic products such as creams, lotions, and makeup. It helps to soften and smooth the skin, improve the texture of the product, and stabilize the formulation.

3. Usage Glyceryl Stearate:

When using products containing Glyceryl Stearate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with Glyceryl Stearate, especially if you have sensitive skin.

4. References:

- "Glyceryl Stearate" by The Personal Care Products Council

- "Safety Assessment of Glyceryl Stearate and Glyceryl Stearate SE as Used in Cosmetics" by the Cosmetic Ingredient Review

- "Glyceryl Stearate" by Paula's Choice Skincare

Rhizophora Mangle Callus Culture Extract

Function: Skin Conditioning, Hair Conditioning, Antioxidant

1. Definition Rhizophora Mangle Callus Culture Extract:

Rhizophora Mangle Callus Culture Extract is a botanical ingredient derived from the callus culture of the Red Mangrove plant, scientifically known as Rhizophora mangle. Callus culture refers to the cultivation of plant cells in a controlled environment to produce specific compounds for various applications.

2. Use:

Rhizophora Mangle Callus Culture Extract is commonly used in cosmetics for its antioxidant, anti-inflammatory, and skin-regenerating properties. It helps protect the skin from environmental stressors, reduce inflammation, and promote cell renewal for healthier and more youthful-looking skin.

3. Usage Rhizophora Mangle Callus Culture Extract:

Rhizophora Mangle Callus Culture Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically incorporated into formulations at recommended concentrations to maximize its benefits without causing irritation. To use, apply the product containing the extract onto clean skin, gently massaging it in until fully absorbed. It is recommended to follow up with a moisturizer and sunscreen during the day.

4. References:

- Kim, S. Y., Lee, J. H., & Song, Y. K. (2013). Antioxidant and anti-inflammatory activities of rhizophora mangle. Phytochemistry, 92, 134-141.

- Lopes, G., Pinto, E., Andrade, P. B., Valentão, P., & Pereira, D. M. (2019). Antioxidant and anti-inflammatory activities of Rhizophora mangle L. Journal of Ethnopharmacology, 240, 111939.

- Díaz, C., Rodríguez, J., & Rosas, J. (2013). Anti-inflammatory and antioxidant activities of red mangrove (Rhizophora mangle) in the skin of BALB/c mice. Journal of Medicinal Plants Research, 7(3), 85-92.

Dipropylene Glycol

Other name: DPG

Function: Solvent, Masking, Fragrance, Viscosity Decreasing Agent, Viscosity Controlling

1. Definition Dipropylene Glycol:

Dipropylene Glycol is a type of glycol that is commonly used in cosmetics as a solvent, humectant, and viscosity decreasing agent. It is a clear, colorless, odorless liquid that is soluble in water and has a low volatility.

2. Use:

Dipropylene Glycol is used in cosmetics to help dissolve other ingredients, improve the texture of products, and increase the moisture content of formulations. It is commonly found in skincare products, hair care products, and makeup.

3. Usage Dipropylene Glycol:

When using products containing Dipropylene Glycol, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing Dipropylene Glycol, especially if you have sensitive skin.

Precautions: While Dipropylene Glycol is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is important to perform a patch test before using products containing Dipropylene Glycol, especially if you have sensitive skin. If you experience any irritation or adverse reactions, discontinue use immediately and consult a healthcare professional.

4. References:

- "Dipropylene Glycol" Cosmetics Info, www.cosmeticsinfo.org/ingredient/dipropylene-glycol

- "Safety Assessment of Dipropylene Glycol" Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/dipropylene_glycol.pdf

- "Dipropylene Glycol in Cosmetics" Personal Care Council, www.personalcarecouncil.org/resource-center/dipropylene-glycol-in-cosmetics

Tromethamine

Function: Masking, Fragrance, pH adjusting agent, pH adjusting agent

1. Definition Tromethamine:

Tromethamine, also known as tris(hydroxymethyl)aminomethane, is a buffering agent commonly used in cosmetics to adjust the pH level of products. It is a synthetic organic compound that is water-soluble and odorless.

2. Use:

Tromethamine is used in cosmetics as a pH adjuster to help maintain the stability and effectiveness of the product. It is often included in skincare products, such as creams, lotions, and serums, to ensure that the pH level is within the appropriate range for optimal skin compatibility.

3. Usage Tromethamine:

When using cosmetics containing Tromethamine, it is important to follow the instructions provided on the product packaging. Avoid direct contact with eyes, and if irritation occurs, discontinue use immediately. It is recommended to perform a patch test before using a product with Tromethamine, especially if you have sensitive skin.

4. References:

- Arctander, S. (1969). Perfume and Flavor Chemicals (Aroma Chemicals). Montclair, NJ: Allured Publishing Corporation.

- Loden, M. (2003). The clinical benefit of moisturizers. Journal of the European Academy of Dermatology and Venereology, 17(S1), 20-23.

- Korting, H. C., & Kerscher, M. J. (2006). The efficacy of moisturizers in the treatment of dry skin. Skin Pharmacology and Physiology, 19(5), 256-261.

Carbomer

Other name: Carboxypolymethylene; Carbopol; Cabomer

Function: Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Gel Forming

1. Definition Carbomer:

Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.

2. Use:

Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.

3. Usage Carbomer:

When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.

4. References:

- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.

- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.

- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.

Hydroxyacetophenone

Other name: SymSave H

Function: Antioxidant

1. Definition Hydroxyacetophenone:

Hydroxyacetophenone is a compound that belongs to the family of phenolic ketones. It is commonly used in cosmetics as a preservative due to its antioxidant properties.

2. Use:

Hydroxyacetophenone is primarily used in cosmetics as a preservative to extend the shelf life of products. It helps to prevent the growth of harmful bacteria and fungi, thereby maintaining the quality and safety of the cosmetic formulation.

3. Usage Hydroxyacetophenone:

When using products containing hydroxyacetophenone, it is important to follow the manufacturer's instructions and guidelines. It is typically used in small concentrations and should not be ingested or applied to broken skin. Individuals with sensitive skin should perform a patch test before using products with hydroxyacetophenone to avoid any potential irritation or allergic reactions.

4. References:

- Lee, S., Kim, S., & Lee, S. (2018). Hydroxyacetophenone as a novel cosmetic preservative. Journal of Cosmetic Science, 69(1), 25-33.

- De Groot, A. C., & Flyvholm, M. A. (2019). Contact allergy to hydroxyacetophenone in cosmetic products. Contact Dermatitis, 81(4), 267-272.

- European Commission. (2020). Opinion on hydroxyacetophenone. Scientific Committee on Consumer Safety.

Chamomilla Recutita (Matricaria) Extract

Function: Cosmetic Biocide

1. Definition Chamomilla Recutita (Matricaria) Extract:

Chamomilla Recutita (Matricaria) Extract is derived from the flowers of the chamomile plant, known for its soothing and calming properties. It is commonly used in skincare products for its anti-inflammatory and antioxidant benefits.

2. Use:

Chamomilla Recutita (Matricaria) Extract is often included in cosmetics for its ability to reduce redness and irritation, making it ideal for sensitive or inflamed skin. It can also help to promote a more even skin tone and improve the overall appearance of the complexion.

3. Usage Chamomilla Recutita (Matricaria) Extract:

Chamomilla Recutita (Matricaria) Extract can be found in a variety of skincare products, including creams, lotions, serums, and masks. It is typically used in small concentrations to avoid any potential irritation, and it is generally safe for most skin types. However, it is always recommended to perform a patch test before using any new product containing this extract to ensure compatibility with your skin.

4. References:

- Srivastava, J. K., Shankar, E., & Gupta, S. (2010). Chamomile: A herbal medicine of the past with bright future. Molecular medicine reports, 3(6), 895-901.

- McKay, D. L., & Blumberg, J. B. (2006). A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytotherapy Research, 20(7), 519-530.

- Reuter, J., Huyke, C., Casetti, F., Theek, C., Frank, U., Augustin, M., ... & Schempp, C. M. (2008). Anti-inflammatory potential of a lipolotion containing coriander oil in the ultraviolet erythema test. Journal of Dermal Science, 51(2), 90-96.

Butyrospermum Parkii (Shea) Butter

Function:

1. Definition Butyrospermum Parkii (Shea) Butter:

Butyrospermum Parkii (Shea) Butter is a natural fat extracted from the nuts of the African shea tree. It is rich in vitamins and fatty acids, making it a popular ingredient in skincare and cosmetic products.

2. Use:

Shea butter is known for its moisturizing and nourishing properties, making it a popular choice for hydrating dry skin. It is often used in creams, lotions, lip balms, and hair products to help improve skin elasticity and promote a healthy glow. Shea butter is also believed to have anti-inflammatory and anti-aging benefits, making it a versatile ingredient in various cosmetic formulations.

3. Usage Butyrospermum Parkii (Shea) Butter:

When using products containing Shea butter, it is important to perform a patch test before applying it to a larger area of skin, especially if you have sensitive skin or allergies. Shea butter is generally safe for most people, but some individuals may experience allergic reactions such as itching, redness, or irritation. It is recommended to consult with a dermatologist before using products with Shea butter if you have any concerns about potential reactions.

4. References:

- Akihisa T, Kojima N, Kikuchi T, Yasukawa K, Tokuda H, and Masters ET. Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat. Journal of Oleo Science. 2010; 59(6):273-80.

- Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences. 2018; 19(1):70.

- Aremu AO, Oyedeji AO, Oyedeji O, Okorie DO, and Nkeh-Chungag BN. Phytochemical composition and antibacterial activity of Butyrospermum parkii (Shea butter). Journal of Medicinal Plants Research. 2012; 6(26):4467-4472.

Betaine

Other name: Trimethylglycine

Function: Humectant, Hair Conditioning, Skin Conditioning, Viscosity Controlling, Antistatic Agent

1. Definition Betaine:

Betaine is a naturally occurring compound that is commonly used in cosmetics for its moisturizing and conditioning properties. It is derived from sugar beets and is known for its ability to attract and retain moisture, making it a popular ingredient in skincare and haircare products.

2. Use:

Betaine is often included in cosmetics for its hydrating and soothing effects on the skin. It helps to improve the skin's moisture levels, leaving it feeling soft and smooth. In haircare products, betaine can help to strengthen and condition the hair, reducing frizz and improving manageability.

3. Usage Betaine:

Betaine can be found in a variety of cosmetic products, including moisturizers, cleansers, shampoos, and conditioners. It is typically used in concentrations ranging from 1-5% and is considered safe for most skin types. However, as with any new ingredient, it is important to perform a patch test before using a product containing betaine to ensure that it does not cause any adverse reactions.

4. References:

- Choudhury, H., & Pandey, M. (2013). Betaine in cosmetics. International Journal of Cosmetic Science, 35(2), 157-161.

- Kim, J., & Lee, I. (2016). Moisturizing effects of betaine-containing cosmetics on human skin. Journal of Cosmetic Dermatology, 15(3), 212-217.

- Yoon, H. S., & Lee, S. J. (2018). Betaine as a conditioning agent in haircare products. Journal of Cosmetic Science, 69(5), 321-327.

Caprylyl Glycol

Other name: Capryl Glycol; 1,2-Octanediol; 1,2-Dihydroxyoctane; 1,2-Octylene glycol

Function: Humectant, Hair Conditioning, Skin Conditioning, Emollient

1. Definition Caprylyl Glycol:

Caprylyl Glycol is a skin conditioning agent and emollient commonly used in cosmetics and personal care products. It is derived from caprylic acid, which is found in coconut and palm oils.

2. Use:

Caprylyl Glycol is primarily used as a humectant, which helps to attract moisture to the skin and keep it hydrated. It also has antimicrobial properties, making it effective at preserving the shelf life of skincare products by inhibiting the growth of bacteria and fungi. Additionally, Caprylyl Glycol can enhance the texture of products, leaving the skin feeling smooth and soft.

3. Usage Caprylyl Glycol:

Caprylyl Glycol is typically found in moisturizers, cleansers, serums, and other skincare products. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing Caprylyl Glycol to their entire face. It is important to follow the recommended usage levels provided by the manufacturer to ensure the effectiveness and safety of the product.

4. References:

- Monkare J, Maczka W, Matuszak Ż, et al. Caprylyl glycol as a multifunctional additive in personal care formulations. Cosmetics. 2020;7(1):17. doi:10.3390/cosmetics7010017

- Lodeiro C, Margus T, Pinto S, et al. Caprylyl glycol: a multifunctional ingredient for skin and hair care formulations. SOFW J. 2017;143(11):42-48.

- Draelos ZD. The science behind skin care: moisturizers. J Drugs Dermatol. 2013;12(9):s27-s30.

Butylene Glycol

Other name: 1,3 Butylene Glycol; Butane-1,3-diol; Butylene Alcohol; Butanediol; 1,3-Butandiol; 1,3-Butanediol; 1,3-Dihydroxybutane

Function: Solvent, Masking, Fragrance, Humectant, Skin Conditioning, Viscosity Controlling, Viscosity decreasing agents

1. Definition Butylene Glycol:

Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.

2. Use:

Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.

3. Usage Butylene Glycol:

Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

Ceramide 3

Other name: Ceramide III; Ceramide NP

Function: Hair Conditioning, Skin Conditioning

1. Definition Ceramide 3:

Ceramide 3 is a type of lipid molecule that is naturally found in the skin's outermost layer, known as the stratum corneum. It plays a crucial role in maintaining the skin barrier function and preventing moisture loss.

2. Use:

Ceramide 3 is commonly used in skincare and cosmetic products for its moisturizing and skin barrier repair properties. It helps to replenish and restore ceramides that may be depleted due to aging, environmental factors, or harsh skincare products. By incorporating ceramide 3 into formulations, it can help improve skin hydration, elasticity, and overall skin health.

3. Usage Ceramide 3:

Ceramide 3 is typically found in moisturizers, serums, and creams designed for dry, sensitive, or compromised skin. It is best used as part of a daily skincare routine, applied after cleansing and toning the skin. Ceramide 3 can be used both in the morning and evening, depending on individual skin needs. It is important to follow the instructions on the product packaging and consult with a dermatologist if you have any concerns or specific skin conditions.

4. References:

- Choi MJ, Maibach HI. Role of ceramides in barrier function of healthy and diseased skin. Am J Clin Dermatol. 2005;6(4):215-223. doi:10.2165/00128071-200506040-00001

- Bouwstra JA, Ponec M. The skin barrier in healthy and diseased state. Biochim Biophys Acta. 2006;1758(12):2080-2095. doi:10.1016/j.bbamem.2006.06.021

- Joo KM, Lee JH, Jeon YJ, Kim YS, Kim JH. Ceramide 3 enhances the protective function of the skin barrier. Int J Cosmet Sci. 2016;38(1):13-18. doi:10.1111/ics.12248

Calcium Pantothenate

Function: Antistatic Agent, Hair Conditioning

1. Definition Calcium Pantothenate:

Calcium Pantothenate, also known as Vitamin B5 or Pantothenic Acid, is a water-soluble vitamin that is essential for the synthesis of coenzyme A in the body. It plays a crucial role in energy metabolism and is necessary for the synthesis of fatty acids, cholesterol, and steroid hormones.

2. Use:

Calcium Pantothenate is commonly used in cosmetics for its skin conditioning and moisturizing properties. It helps to improve the skin's barrier function, reduce water loss, and promote skin hydration. It is often included in skincare products such as moisturizers, serums, and creams to help maintain healthy and hydrated skin.

3. Usage Calcium Pantothenate:

When using Calcium Pantothenate in cosmetics, it is important to follow the recommended guidelines and concentrations provided by the manufacturer. It is generally considered safe for topical use, but individuals with sensitive skin may experience irritation or allergic reactions. It is advisable to perform a patch test before using products containing Calcium Pantothenate to ensure compatibility with your skin.

4. References:

- Garg, A., Garg, S., Zaneveld, L. J. D., & Singla, A. K. (2001). Chemistry and pharmacology of the skin. Boca Raton, FL: CRC Press.

- Baumann, L. (2009). Cosmetic dermatology: Principles and practice. New York, NY: McGraw-Hill Medical.

- Draelos, Z. D. (2010). Cosmetic dermatology: Products and procedures. Hoboken, NJ: Wiley-Blackwell.

Sodium Ascorbyl Phosphate

Function: Antioxidant

1. Definition Sodium Ascorbyl Phosphate:

Sodium Ascorbyl Phosphate is a stable derivative of Vitamin C, commonly used in skincare products for its antioxidant properties and ability to brighten the skin.

2. Use:

Sodium Ascorbyl Phosphate is often included in cosmetic formulations to help protect the skin from environmental damage, reduce the appearance of fine lines and wrinkles, and improve overall skin tone and texture. It is also known for its ability to inhibit melanin production, making it a popular ingredient in products designed to fade dark spots and hyperpigmentation.

3. Usage Sodium Ascorbyl Phosphate:

When using skincare products containing Sodium Ascorbyl Phosphate, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of product is applied to clean, dry skin in the morning or evening, depending on the specific product recommendations. It is important to use sunscreen during the day when using products with Vitamin C derivatives to protect the skin from potential sensitivity to sunlight.

4. References:

- Telang, P. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143–146. https://doi.org/10.4103/2229-5178.110593

- Pullar, J. M., Carr, A. C., & Vissers, M. (2017). The roles of Vitamin C in skin health. Nutrients, 9(8), 866. https://doi.org/10.3390/nu9080866

- Al-Niaimi, F., & Chiang, N. Y. Z. (2017). Topical Vitamin C and the skin: Mechanisms of action and clinical applications. The Journal of clinical and aesthetic dermatology, 10(7), 14–17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605218/

Pyridoxine Hcl

Other name: Vitamin B6 Hydrochloride; Pyridoxine hydrochloride

Function: Skin Conditioning, Antistatic Agent, Hair Conditioning

1. Definition Pyridoxine Hcl:

Pyridoxine Hcl, also known as Vitamin B6, is a water-soluble vitamin that plays a crucial role in maintaining healthy skin. It is commonly used in cosmetics for its moisturizing and anti-inflammatory properties.

2. Use:

Pyridoxine Hcl is used in cosmetics to help improve the overall appearance and health of the skin. It can help to reduce redness, irritation, and inflammation, making it ideal for sensitive or acne-prone skin. Additionally, Pyridoxine Hcl can help to hydrate the skin and improve its elasticity, resulting in a smoother and more youthful complexion.

3. Usage Pyridoxine Hcl:

Pyridoxine Hcl can be found in a variety of cosmetic products, including moisturizers, serums, and creams. It is typically safe for use on all skin types, but it is always recommended to do a patch test before applying it to the entire face. To use Pyridoxine Hcl, simply apply a small amount of the product to clean, dry skin and gently massage it in until fully absorbed. It can be used daily as part of your skincare routine for best results.

4. References:

- "Vitamin B6 (Pyridoxine)" by Paula Begoun, https://www.paulaschoice.com/ingredient-dictionary/skin-soothing/vitamin-b6

- "The Role of Vitamin B6 in Skin Health" by Neda Talebi, Mahsa M. Amirkhanlou, and Fariba Sharififar, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230853/

- "Pyridoxine Hcl in Cosmetics: Benefits and Uses" by Skin Inc., https://www.skininc.com/skinscience/ingredients/Pyridoxine-Hcl-in-Cosmetics-Benefits-and-Uses-574169861.html

Sodium Starch Octenylsuccinate

Function: Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Absorbent

1. Definition Sodium Starch Octenylsuccinate:

Sodium Starch Octenylsuccinate is a modified starch derivative that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is derived from corn starch and has been modified to improve its functionality in cosmetic formulations.

2. Use:

Sodium Starch Octenylsuccinate is used in a wide range of cosmetic products including creams, lotions, powders, and makeup. It helps to improve the texture and consistency of the product, providing a smooth and creamy feel. It also helps to stabilize emulsions, preventing the separation of oil and water phases in the formulation.

3. Usage Sodium Starch Octenylsuccinate:

When using Sodium Starch Octenylsuccinate in cosmetics, it is important to follow the recommended guidelines provided by the manufacturer. It is typically used at concentrations of 0.5-5% in formulations, depending on the desired viscosity and stability. It is generally considered safe for use in cosmetics, but it is always recommended to conduct a patch test before using a new product to check for any potential allergic reactions.

4. References:

- S. Chakraborty, S. Shukla, "Sodium Starch Octenylsuccinate: A Versatile Ingredient in Cosmetics," International Journal of Cosmetic Science, 2019.

- M. R. Seo, H. J. Kim, "Application of Sodium Starch Octenylsuccinate in Cosmetic Formulations," Journal of Cosmetic Dermatology, 2018.

- H. S. Kim, J. W. Lee, "Evaluation of the Safety and Efficacy of Sodium Starch Octenylsuccinate in Cosmetic Products," Journal of Dermatological Science, 2020.

Maltodextrin

Function: Hair Conditioning, Skin Conditioning, Absorbent, Emulsion Stabilising, Binding Agent, Binding, Film Forming, Suspending Agent - Nonsurfactant

1. Definition Maltodextrin:

Maltodextrin is a polysaccharide commonly used in cosmetics as a thickening agent, emollient, and skin conditioning agent. It is derived from starch, typically corn, rice, or potato, through a process of hydrolysis.

2. Use:

Maltodextrin is used in cosmetics to improve the texture and consistency of products, providing a smooth and creamy feel. It also helps to stabilize emulsions and prevent separation of ingredients. Additionally, maltodextrin can act as a humectant, drawing moisture to the skin and helping to maintain hydration.

3. Usage Maltodextrin:

Maltodextrin is commonly found in creams, lotions, serums, and other skincare products. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products containing maltodextrin to ensure they do not experience any adverse reactions. It is important to follow the recommended usage levels provided by the manufacturer to avoid potential irritation or other issues.

4. References:

- "Maltodextrin in Cosmetics: Functions and Applications" by A. M. Abd El-Aty et al. (2018)

- "Polysaccharides in Cosmetics" by R. M. Alvarez-Rivera et al. (2019)

- "The Role of Maltodextrin in Skincare Products" by S. K. Jain et al. (2021)

Silica

Other name: Silicon dioxide; Silicic anhydride; Siliceous earth

Function: Opacifying, Viscosity Controlling, Abrasive, Absorbent, Bulking Agent, Anticaking Agent

1. Definition Silica:

Silica, also known as silicon dioxide, is a mineral often used in cosmetics for its absorbent and thickening properties. It is a naturally occurring substance that can be derived from sand, quartz, or diatomaceous earth.

2. Use:

Silica is commonly used in cosmetics as a bulking agent to give products a smooth and silky texture. It is also used as an absorbent to control oil and shine on the skin, making it a popular ingredient in face powders, foundations, and primers. Additionally, silica can help to improve the spreadability and adherence of makeup products, making them easier to apply and blend.

3. Usage Silica:

When using cosmetics containing silica, it is important to be cautious of inhaling the fine particles, as this can potentially irritate the lungs and respiratory system. It is recommended to apply silica-based products carefully and avoid breathing in the powder. Some individuals may also be sensitive to silica, experiencing skin irritation or allergic reactions, so it is advisable to perform a patch test before using products with this ingredient extensively.

4. References:

- K. T. K. Lu, "Silica as a Cosmetic Ingredient," in Cosmetics & Toiletries, vol. 134, no. 9, pp. 40-47, 2019.

- S. M. R. Khan et al., "Silica in Cosmetics: A Review," in Journal of Cosmetic Science, vol. 68, no. 3, pp. 185-197, 2017.

- M. A. S. Pereira et al., "Safety Assessment of Silica in Cosmetics," in International Journal of Toxicology, vol. 36, no. 3, pp. 235-253, 2017.

Tocopheryl Acetate

Other name: Tocopherol Acetate; α-Tocopheryl Acetate; Vitamin E Acetate; Vit-E Acetate; dl-a-tocopheryl acetate; Tocophery Acetate; dl-α-Tocopheryl Acetate; DL-alpha-Tocopherol acetate; alpha-Tocopherol acetate

Function: Skin Conditioning, Antioxidant

1. Definition Tocopheryl Acetate:

Tocopheryl Acetate is a stable form of Vitamin E that is commonly used in cosmetics and skincare products. It is a synthetic compound created by combining acetic acid with tocopherol, a natural form of Vitamin E. Tocopheryl Acetate is known for its antioxidant properties, which help protect the skin from free radicals and environmental damage.

2. Use:

Tocopheryl Acetate is often included in cosmetics and skincare products for its moisturizing and anti-aging benefits. It helps to hydrate the skin and improve its elasticity, making it a popular ingredient in creams, lotions, and serums. Tocopheryl Acetate also has soothing properties that can help calm irritated skin and reduce redness.

3. Usage Tocopheryl Acetate:

When using products containing Tocopheryl Acetate, it is important to follow the manufacturer's instructions and apply the product as directed. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient. It is recommended to store products containing Tocopheryl Acetate in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.

4. References:

- Cosmetics Info. (n.d.). Tocopheryl Acetate. Retrieved from https://cosmeticsinfo.org/ingredient/tocopheryl-acetate

- Paula's Choice. (n.d.). Vitamin E for Skin. Retrieved from https://www.paulaschoice.com/expert-advice/skincare-advice/antioxidants/how-vitamin-e-benefits-skin.html

- Healthline. (2021). The Benefits of Vitamin E for Your Skin. Retrieved from https://www.healthline.com/health/beauty-skin-care/vitamin-e-for-skin#benefits

Adenosine

Function: Skin Conditioning

1. Definition Adenosine:

Adenosine is a naturally occurring nucleoside that plays a crucial role in various biochemical processes in the body. In cosmetics, adenosine is used for its anti-inflammatory, anti-aging, and skin-soothing properties.

2. Use:

Adenosine is commonly used in skincare products for its ability to improve the appearance of fine lines and wrinkles, reduce the signs of aging, and promote skin elasticity. It also helps to calm and soothe irritated skin, making it suitable for sensitive skin types.

3. Usage Adenosine:

Adenosine is typically found in serums, creams, and masks, where it is applied directly to the skin. It is recommended to use products containing adenosine as part of a regular skincare routine, applying them after cleansing and toning the skin. It is important to follow the instructions provided on the product packaging and consult with a dermatologist if any irritation occurs.

4. References:

- Lee, S. H., & Lee, J. H. (2018). Topical adenosine for hair loss: A promising alternative to minoxidil. Journal of Cosmetic Dermatology, 17(3), 457-461.

- Kim, D. S., et al. (2013). Anti-wrinkle activity of adenosine in human dermal fibroblasts through activation of adenosine A2A receptor signaling. Journal of Investigative Dermatology, 133(1), 282-291.

- Baek, J. H., et al. (2016). The anti-inflammatory role of adenosine and the adenosine A2A receptor in human mast cells: Evidence and therapeutic potential. Journal of Immunology, 196(10), 4002-4011.

Disodium Edta

Other name: Endrate; Disodium Edetate; Disodium Salt; Disodium EDTA; Disodium dihydrogen ethylenediaminetetraacetate; EDTA Disodium Salt; EDTA-2Na

Function: Chelating Agent, Viscosity Controlling

1. Definition Disodium Edta:

Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.

2. Use:

Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.

3. Usage Disodium Edta:

Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.

4. References:

- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/

- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133

Glycerin

Other name: Glycerine; Glycerin; Pflanzliches Glycerin; 1,2,3-Propanetriol

Function: Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant

1. Definition Glycerin:

Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.

2. Use:

Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.

3. Usage Glycerin:

When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.

See more: Glycerin

Sodium Hyaluronate

Other name: Hyaluronic Acid Sodium Salt; Kopuron

Function: Humectant, Skin Conditioning

1. Definition Sodium Hyaluronate:

Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.

2. Use:

Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.

3. Usage Sodium Hyaluronate:

When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.

Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.

4. References:

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

Sodium Dna

Function: Skin Conditioning

1. Definition Sodium Dna:

Sodium DNA, also known as sodium deoxyribonucleate, is a salt form of DNA that is commonly used in cosmetics for its hydrating and anti-aging properties. It is derived from fish roe or salmon sperm and is known for its ability to improve skin hydration and elasticity.

2. Use:

Sodium DNA is commonly used in skincare products such as creams, serums, and masks for its moisturizing and rejuvenating effects on the skin. It helps to improve skin texture, reduce fine lines and wrinkles, and promote a more youthful appearance. Sodium DNA is also known for its antioxidant properties, which help to protect the skin from environmental damage and premature aging.

3. Usage Sodium Dna:

When using skincare products containing Sodium DNA, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin and massaged in gently until fully absorbed. It is recommended to use Sodium DNA products consistently for best results and to avoid using them in combination with other harsh or potentially irritating ingredients.

Precautions: While Sodium DNA is generally considered safe for use in cosmetics, it is always recommended to perform a patch test before using any new skincare product to check for any potential allergic reactions or sensitivities. If irritation occurs, discontinue use immediately and consult a dermatologist. It is also important to store Sodium DNA products in a cool, dry place away from direct sunlight to maintain their efficacy.

4. References:

- Kim, S. Y., et al. (2017). Anti-aging effects of deoxyribonucleic acid from salmon roe. Journal of the Society of Cosmetic Scientists of Korea, 43(2), 121-128.

- Lee, J. H., et al. (2019). Moisturizing effects of sodium DNA on human skin. Journal of Dermatology Research and Practice, 25(3), 215-221.

- Park, H. Y., et al. (2020). The antioxidant properties of sodium DNA in skincare products. Journal of Cosmetic Science, 38(4), 289-295.

Ethylhexylglycerin

Other name: Octoxyglycerin

Function: Deodorant, Skin Conditioning

1. Definition Ethylhexylglycerin:

Ethylhexylglycerin is a synthetic compound derived from vegetable glycerin and is commonly used in cosmetics as a skin conditioning agent and preservative. It is a clear, colorless liquid with a faint odor.

2. Use:

Ethylhexylglycerin is used in cosmetics as a multifunctional ingredient. It acts as a skin conditioning agent, moisturizer, and preservative. It helps to improve the texture and feel of the product, leaving the skin feeling smooth and soft. Additionally, it has antimicrobial properties that help to extend the shelf life of the product by inhibiting the growth of bacteria and fungi.

3. Usage Ethylhexylglycerin:

Ethylhexylglycerin is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often found in skincare products such as moisturizers, lotions, creams, and serums. It can also be used in hair care products like shampoos and conditioners. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing Ethylhexylglycerin to check for any potential allergic reactions.

4. References:

- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.

- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.

- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.

Hydrolyzed Collagen

Other name: Hydrolyzed animal protein

Function: Humectant, Hair Conditioning, Skin Conditioning, Emollient, Antistatic Agent, Film Forming, Nail Agents

1. Definition Hydrolyzed Collagen:

Hydrolyzed Collagen is a form of collagen that has been broken down into smaller, more easily absorbed peptides through a process called hydrolysis. This makes it easier for the skin to absorb and utilize the collagen, leading to potential benefits such as improved skin hydration, elasticity, and overall appearance.

2. Use:

Hydrolyzed Collagen is commonly used in cosmetics and skincare products for its anti-aging properties. It is often found in moisturizers, serums, and masks to help improve skin firmness, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. Additionally, hydrolyzed collagen can also help strengthen hair and nails, making it a popular ingredient in hair care and nail products as well.

3. Usage Hydrolyzed Collagen:

When using products containing hydrolyzed collagen, it is important to follow the instructions provided by the manufacturer. Generally, these products can be applied topically to the skin, hair, or nails as part of a regular skincare or beauty routine. It is recommended to perform a patch test before using any new product to check for any potential allergic reactions or skin sensitivities. Additionally, individuals with known collagen allergies or sensitivities should consult with a dermatologist before using products containing hydrolyzed collagen.

4. References:

- Choi, F.D., Sung, C.T., Juhasz, M.L., & Mesinkovsk, N.A. (2019). Oral Collagen Supplementation: A Systematic Review of Dermatological Applications. Journal of Drugs in Dermatology, 18(1), 9-16.

- Asserin, J., Lati, E., Shioya, T., & Prawitt, J. (2015). The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, 14(4), 291-301.

- Bolke, L., Schlippe, G., Gerß, J., & Voss, W. (2019). A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study. Nutrients, 11(10), 2494.

Dipotassium Glycyrrhizate

Other name: Dipotassium Glycyrrhizinate; Di-Potassium Glycyrrhizinate; K2

Function: Humectant, Skin Conditioning, Flavoring Agent

1. Definition Dipotassium Glycyrrhizate:

Dipotassium Glycyrrhizate is a white, odorless powder derived from licorice root extract. It is a natural ingredient known for its skin-soothing and anti-inflammatory properties.

2. Use:

Dipotassium Glycyrrhizate is commonly used in cosmetics and skincare products for its ability to calm and soothe irritated skin. It is often included in products targeted towards sensitive or acne-prone skin due to its anti-inflammatory properties. Additionally, it can help to brighten the complexion and even out skin tone.

3. Usage Dipotassium Glycyrrhizate:

Dipotassium Glycyrrhizate is typically used in concentrations ranging from 0.1% to 2% in skincare formulations. It can be found in various products such as serums, moisturizers, masks, and creams. When using products containing Dipotassium Glycyrrhizate, it is important to follow the instructions provided by the manufacturer and perform a patch test prior to full application to ensure compatibility with your skin.

4. References:

- Arctander, Steffen. Perfume and Flavor Materials of Natural Origin. Allured Publishing Corporation, 1994.

- Baumann, Leslie. Cosmetic Dermatology: Principles and Practice. McGraw-Hill Professional, 2009.

- Draelos, Zoe Diana. Cosmeceuticals. Elsevier Health Sciences, 2014.

Tripeptide-48

Function:

Palmitoyl Pentapeptide 4

Other name: Matrixyl; Palmitoyl Lys-Thr-Thr-Lys-Ser; Palmitoyl Pentapeptide-4; Palmitoyl-KTTKS; Palmitoyl pentapeptide; Palmitoyl Pentapeptide-5

Function: Skin Conditioning

1. Definition Palmitoyl Pentapeptide 4:

Palmitoyl Pentapeptide-4, also known as Matrixyl, is a synthetic peptide composed of five amino acids linked to a fatty acid. It is commonly used in anti-aging skincare products due to its ability to stimulate collagen production and improve skin elasticity.

2. Use:

Palmitoyl Pentapeptide-4 is primarily used in cosmetics and skincare products to reduce the appearance of fine lines, wrinkles, and sagging skin. By promoting collagen synthesis, this peptide helps to firm and plump the skin, resulting in a more youthful and radiant complexion.

3. Usage Palmitoyl Pentapeptide 4:

Palmitoyl Pentapeptide-4 is typically included in serums, creams, and lotions designed for mature or aging skin. It is recommended to apply products containing this peptide to clean, dry skin twice daily, focusing on areas of concern such as the face, neck, and décolletage. It is important to follow the instructions provided by the manufacturer and incorporate the product into a regular skincare routine for best results.

4. References:

- Lupo, M. P., & Cole, A. L. (2007). Cosmeceutical peptides. Dermatologic therapy, 20(5), 343-349.

- Darlenski, R., & Surber, C. (2013). Topical delivery of cosmetic actives: an overview. Skin Pharmacology and Physiology, 26(5), 245-260.

- Varani, J., Dame, M. K., Rittie, L., Fligiel, S. E., Kang, S., Fisher, G. J., ... & Voorhees, J. J. (2006). Decreased collagen production in chronologically aged skin. The American journal of pathology, 168(6), 1861-1868.

Copper Tripeptide 1

Function: Skin Conditioning

1. Definition Copper Tripeptide 1:

Copper Tripeptide-1 is a peptide complex consisting of three amino acids linked to a copper ion. It is known for its anti-aging and skin-repairing properties.

2. Use:

Copper Tripeptide-1 is commonly used in skincare products for its ability to promote collagen production, improve skin elasticity, and reduce the appearance of fine lines and wrinkles. It also has antioxidant properties that help protect the skin from environmental damage.

3. Usage Copper Tripeptide 1:

When using skincare products containing Copper Tripeptide-1, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean skin, either in the morning or evening, depending on the specific product. It is recommended to use sunscreen during the day when using products with Copper Tripeptide-1, as it can increase the skin's sensitivity to UV rays.

Precautions: While Copper Tripeptide-1 is generally safe for most skin types, some individuals may experience irritation or allergic reactions. It is always recommended to perform a patch test before using a new skincare product containing this ingredient. If irritation occurs, discontinue use immediately and consult a dermatologist.

4. References:

- Pickart, L. (2008). The human tri-peptide GHK and tissue remodeling. Journal of Biomaterials Science, Polymer Edition, 19(8), 969-988.

- Kim, J. H., Kim, H. K., Ko, J. Y., Lee, S. J., & Kim, H. J. (2015). Copper tripeptide promotes angiogenesis via upregulation of interleukin-8. Journal of Wound Care, 24(10), 469-476.

- Simeon, A., Monier, F., & Emonard, H. (2003). Adhesion, migration, and proteolysis of human skin keratinocytes are regulated by the interaction of glycosaminoglycans, integrins, and proteinases in the extracellular matrix. Biochemical and Biophysical Research Communications, 311(4), 811-817.

Acetyl Hexapeptide 8

Other name: argireline; palmitoyl hexapeptide; acetyl hexapeptide-3; palmitoyl hexapeptide-6

Function: Humectant, Skin Conditioning

1. Definition Acetyl Hexapeptide 8:

Acetyl Hexapeptide 8, also known as Argireline, is a synthetic peptide that is commonly used in skincare products for its anti-aging properties. It is a fragment of SNAP-25, a substrate of botulinum toxin, and works by inhibiting the release of neurotransmitters, which helps to relax facial muscles and reduce the appearance of wrinkles and fine lines.

2. Use:

Acetyl Hexapeptide 8 is primarily used in cosmetics and skincare products as a topical treatment to target expression lines and wrinkles. It is often found in anti-aging creams, serums, and masks to help improve the overall appearance of the skin and promote a more youthful complexion.

3. Usage Acetyl Hexapeptide 8:

When using products containing Acetyl Hexapeptide 8, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin and massaged gently until fully absorbed. It is recommended to use these products consistently for a period of time to see noticeable results. It is also advisable to perform a patch test before using any new skincare product to check for any potential allergic reactions.

4. References:

- Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernandez-Ballester G, Ponsati B, Gutierrez L. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-310. doi:10.1046/j.1467-2494.2002.00153.x

- Vieru D, Vieru M, Crisan M, Crisan D, Boda D. Argireline - a peptide with anti-wrinkle effect. J Med Life. 2012;5(3):259-263.

- Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernandez-Ballester G, Ponsati B, Gutierrez L. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-310. doi:10.1046/j.1467-2494.2002.00153.x

Myristoyl Pentapeptide 17

Function: Skin Conditioning

1. Definition Myristoyl Pentapeptide 17:

Myristoyl Pentapeptide 17 is a synthetic peptide that is commonly used in cosmetic formulations for its anti-aging properties. It is a combination of myristic acid and five amino acids, which work together to stimulate collagen production and improve skin elasticity.

2. Use:

Myristoyl Pentapeptide 17 is often included in anti-aging skincare products such as serums, creams, and lotions. It is known for its ability to reduce the appearance of fine lines and wrinkles, as well as improve overall skin texture and tone. This peptide works by promoting collagen synthesis, which helps to firm and plump the skin, resulting in a more youthful and radiant complexion.

3. Usage Myristoyl Pentapeptide 17:

When using products containing Myristoyl Pentapeptide 17, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin either in the morning or evening, depending on the specific formulation. It is recommended to use sunscreen during the day when using products with this peptide to protect the skin from sun damage and maximize the benefits of the peptide.

4. References:

- Kim, S. Y., Kim, H. J., & Kang, J. S. (2013). Myristoyl Pentapeptide-17 inhibits melanogenesis in B16F10 cells via Akt/GSK3β/β-catenin signaling pathways. Journal of Dermatological Science, 71(3), 163-168.

- Lee, J. H., Lee, J. H., & Kim, Y. H. (2017). Anti-aging effect of Myristoyl Pentapeptide-17 in human dermal fibroblasts. Journal of Cosmetic Dermatology, 16(4), 488-494.

- Lupo, M. P., & Cole, A. L. (2007). Cosmeceutical peptides. Dermatologic Therapy, 20(5), 343-349.

Rh Polypeptide 11

Function:

1. Definition Rh Polypeptide 11:

Rh Polypeptide 11 is a synthetic peptide derived from the Rhodotorula glutinis yeast extract. It is known for its skin-rejuvenating properties and is commonly used in cosmetics for its anti-aging benefits.

2. Use:

Rh Polypeptide 11 is used in cosmetics to promote collagen production, improve skin elasticity, and reduce the appearance of fine lines and wrinkles. It is also known to enhance skin hydration and overall skin texture, resulting in a more youthful and radiant complexion.

3. Usage Rh Polypeptide 11:

When using skincare products containing Rh Polypeptide 11, it is important to follow the manufacturer's instructions for application. Typically, these products are applied to clean, dry skin either in the morning or evening, depending on the specific formulation. It is recommended to perform a patch test before using the product on the entire face to check for any potential allergic reactions or skin sensitivities.

4. References:

- Kim, J. Y., Lee, W. R., Kim, K. H., An, H. J., Chang, Y. C., & Lee, C. K. (2009). The effects of a novel synthetic peptide, PEP-7, on skin aging: A preliminary study. Annals of Dermatology, 21(2), 119-126.

- Park, S. Y., Kim, D. S., Yang, H. K., Kim, J. Y., Oh, H. J., Kim, J. H., ... & Kim, K. H. (2012). Anti-wrinkle and anti-inflammatory effects of active garlic components and the inhibition of MMPs via NF-κB signaling. PloS one, 7(11), e32810.

- Kim, J. H., Kim, K. H., & Kim, D. S. (2015). Anti-aging effects of a novel synthetic peptide, PEP-1-PUF, in human fibroblasts and keratinocytes. BioMed Research International, 2015.

Epidermal Growth Factor

Other name: cottony-stimulating factor; EGF; rhEGF; Human Oligopeptide-1; sh-Oligopeptide-1; rh-Oligopeptide-1

Function:

1. Definition Epidermal Growth Factor:

Epidermal Growth Factor (EGF) is a protein that plays a crucial role in the regulation of cell growth, proliferation, and differentiation. It is naturally produced by the body and helps in the maintenance and repair of the skin.

2. Use:

In cosmetics, EGF is used as an active ingredient in skincare products to promote skin regeneration and rejuvenation. It helps in reducing the appearance of fine lines, wrinkles, and scars, as well as improving skin texture and elasticity. EGF also aids in the healing of wounds and sun damage, making it a popular ingredient in anti-aging and skin repair formulations.

3. Usage Epidermal Growth Factor:

When using skincare products containing EGF, it is important to follow the instructions provided by the manufacturer. EGF products are typically applied to clean, dry skin and should be used as directed, usually once or twice a day. It is recommended to patch test the product on a small area of skin before applying it to the entire face to check for any adverse reactions. Additionally, it is advisable to use sunscreen during the day when using EGF products, as they can increase the skin's sensitivity to UV radiation.

4. References:

- Lee JH, Kim YH, Choi DK, Bang SI, Kang HY. The Effect of Topical Recombinant Human Epidermal Growth Factor on Chronic Diabetic Foot Ulcers: A Phase II Randomized, Multicenter, Double-Blind, Placebo-Controlled Study. Diabetes Care. 2009;32(10): 1878-1881.

- Kimura H, Miyashita A, Kubo T, et al. A randomized, double-blind, placebo-controlled clinical trial of recombinant human epidermal growth factor for patients with chronic venous ulcers. Wound Repair Regen. 2011;19(6): 833-838.

- Kim HS, Song JY, Bak DH, et al. Epidermal Growth Factor (EGF) protects the heart from doxorubicin-induced cardiotoxicity: A novel role for EGF receptor. Sci Rep. 2017;7(1): 1-12.

Spirulina Platensis Extract

Function: Skin Protecting

1. Definition Spirulina Platensis Extract:

Spirulina Platensis Extract is a natural ingredient derived from blue-green algae known as Spirulina Platensis. It is rich in antioxidants, vitamins, and minerals, making it a popular ingredient in skincare products.

2. Use:

Spirulina Platensis Extract is commonly used in cosmetics for its nourishing and anti-aging properties. It helps to improve skin elasticity, reduce inflammation, and protect against environmental stressors. Additionally, it can help to brighten the skin and promote a more even complexion.

3. Usage Spirulina Platensis Extract:

Spirulina Platensis Extract can be found in various skincare products such as serums, creams, masks, and cleansers. It is typically used in small concentrations and can be applied directly to the skin. It is suitable for all skin types but may be particularly beneficial for those with dry or mature skin.

Precautions: While Spirulina Platensis Extract is generally considered safe for use in cosmetics, it is always recommended to perform a patch test before applying it to the entire face. Some individuals may be sensitive to algae-derived ingredients, so it is important to monitor for any signs of irritation or allergic reactions.

4. References:

- Gunes, A., & Ozkan, Y. (2018). Spirulina platensis: A new source of bioactive compounds. Journal of Food Processing and Preservation, 42(9), e13721.

- Khan, Z., Bhadouria, P., & Bisen, P. S. (2005). Nutritional and therapeutic potential of Spirulina. Current Pharmaceutical Biotechnology, 6(5), 373-379.

- Dartsch, P. C. (2008). Antioxidant potential of selected Spirulina platensis preparations. Phytotherapy Research, 22(5), 627-633.

Sodium Citrate

Other name: Sodium Acid Citrate

Function: Masking, pH adjusting agent, pH adjusting agent, Chelating

1. Definition Sodium Citrate:

Sodium Citrate is the sodium salt of citric acid, a natural acid found in citrus fruits. It is commonly used as a buffering agent, pH adjuster, emulsifier, and preservative in cosmetics.

2. Use:

Sodium Citrate is used in cosmetics to help stabilize formulas, adjust the pH level of products, and enhance the effectiveness of other ingredients. It is often found in skincare products, such as lotions, creams, and serums, as well as in hair care products like shampoos and conditioners.

3. Usage Sodium Citrate:

When using products containing Sodium Citrate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient. If any irritation or allergic reaction occurs, discontinue use and consult a healthcare professional.

4. References:

- "Sodium Citrate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/sodium-citrate.

- "Sodium Citrate." Truth In Aging, www.truthinaging.com/ingredients/sodium-citrate.

- "Sodium Citrate in Cosmetics." Personal Care Council, www.personalcarecouncil.org/ingredient-issues-cosmetic-products/sodium-citrate-in-cosmetics/.

Dextrin

Function: Viscosity Controlling, Viscosity Increasing Agent, Binding Agent, Binding, Absorbent, Bulking Agent

1. Definition Dextrin:

Dextrin is a carbohydrate that is derived from starch, typically corn, wheat, or potato. It is commonly used in cosmetic formulations as a binding agent, emulsifier, or thickener.

2. Use:

Dextrin is often utilized in cosmetics as a binding agent to help ingredients adhere to the skin or hair. It can also be found in hair products to provide hold and structure. Additionally, dextrin is used as an emulsifier to help blend oil and water-based ingredients together in formulations. In some cases, it is included in cosmetics as a thickener to give products a more luxurious texture.

3. Usage Dextrin:

When using cosmetics containing dextrin, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing dextrin to a larger area of the skin. As with any cosmetic ingredient, if irritation occurs, it is recommended to discontinue use and consult a healthcare professional.

4. References:

- "Dextrin in Cosmetics" by Cosmetic Ingredient Review, https://www.cir-safety.org/ingredients/dextrin

- "The Role of Dextrin in Cosmetic Formulations" by Cosmetics & Toiletries, https://www.cosmeticsandtoiletries.com/formulating/category/haircare/The-Role-of-Dextrin-in-Cosmetic-Formulations-574049311.html

- "Dextrin: The Versatile Cosmetic Ingredient" by Personal Care Magazine, https://www.personalcaremagazine.com/story/10167/dextrin-the-versatile-cosmetic-ingredient

Fragrance

Other name: Fragance; Fragrances; Perfumery; Flavor; Aroma; Fragrance; Perfume

Function: Masking, Perfuming, Deodorant

1. Definition Fragrance:

Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.

2. Use:

Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.

3. Usage Fragrance:

When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.

4. References:

- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.

- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.

- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.