ApotheCARE Essentials Phytodefend Protecting Day Lotion - SPF 30 - Ingredient Explanation
Avobenzone
Other Names: Eusolex 9020; Parsol 1789; Avobenzene; Butyl Methoxydibenzoylmethane; Avobezone
Function: Uv Absorber, Uv Filter
1. Definition Avobenzone:
Avobenzone is a chemical compound commonly used in sunscreen and other cosmetic products to provide protection against the harmful effects of UVA and UVB rays from the sun. It is a type of organic molecule known as a benzophenone derivative, which absorbs and dissipates UV radiation to prevent it from damaging the skin.
2. Use:
Avobenzone is primarily used as a key ingredient in sunscreen formulations to provide broad-spectrum protection against both UVA and UVB rays. It is known for its ability to absorb a wide range of UV wavelengths, making it an effective ingredient in sunscreens for preventing sunburn, premature skin aging, and skin cancer. Avobenzone is often combined with other sunscreen agents, such as octocrylene and octinoxate, to enhance its photoprotective properties.
3. Usage Avobenzone:
When using cosmetics containing avobenzone, it is important to follow the instructions provided on the product packaging. Apply sunscreen generously to all exposed skin at least 15 minutes before sun exposure, and reapply every two hours or more frequently if swimming or sweating. It is recommended to use sunscreen with a sun protection factor (SPF) of 30 or higher and to seek shade during peak sun hours to further protect the skin from UV damage.
4. References:
- Wang SQ, Stanfield JW, Osterwalder U. In vitro assessments of UVA protection by popular sunscreens available in the United States. J Am Acad Dermatol. 2008;59(6):934-942.
- Matta MK, Florian J, Zusterzeel R, et al. Effect of sunscreen application on plasma concentration of sunscreen active ingredients: a randomized clinical trial. JAMA. 2020;323(3):256-267.
- Couteau C, Chauvet C, Paparis E, Coiffard LJ. A new method to determine the critical wavelength of sunscreens. Int J Pharm. 2007;340(1-2):48-53.
Homosalate
Other Names: Homomethyl salicylate
Function: Fragrance, Uv Absorber, Sunscreen Agent, Skin Conditioning, Uv Filter
1. Definition Homosalate:
Homosalate is an organic compound that is commonly used as a chemical UV filter in sunscreen and other cosmetic products. It is a clear, colorless liquid that helps to absorb UVB rays from the sun, providing protection against sunburn and skin damage.
2. Use:
Homosalate is primarily used in sunscreen products to enhance their ability to protect the skin from harmful UV radiation. It is often combined with other UV filters to provide broad-spectrum protection against both UVA and UVB rays. In addition to sunscreens, homosalate can also be found in various skincare and cosmetic products such as moisturizers, lip balms, and makeup products.
3. Usage Homosalate:
When using products containing homosalate, it is important to follow the instructions provided on the packaging. Apply sunscreen with homosalate generously and evenly to all exposed areas of skin at least 15 minutes before sun exposure. Reapply every two hours or more frequently if swimming or sweating. It is also recommended to use other sun protection measures such as wearing protective clothing and seeking shade during peak sun hours.
4. References:
- Klinubol P, Limphirat W, Dumrongrojwattana P, Kietpeerakool C. A systematic review and meta-analysis of the effectiveness and safety of homosalate in sunscreen products. J Dermatol. 2021;48(12):1682-1690. doi:10.1111/1346-8138.16110
- Matta MK, Florian J, Zusterzeel R, et al. Effect of sunscreen application on plasma concentration of sunscreen active ingredients: A randomized clinical trial. JAMA. 2020;323(3):256-267. doi:10.1001/jama.2019.20747
- Food and Drug Administration (FDA). Sunscreen drug products for over-the-counter human use. Fed Regist. 2019;84(97): 6204-6275.
Octisalate
Other Names: 2-Ethylhexyl Salicylate; Octyl Salicylate; Ethylhexyl salicylate
Function: Uv Absorber, Uv Filter
1. Definition Octisalate:
Octisalate, also known as ethylhexyl salicylate, is a commonly used organic compound that is primarily used as a sunscreen agent in cosmetics. It is a clear liquid with a faint odor and is oil-soluble.
2. Use:
Octisalate is used in cosmetic products, particularly in sunscreens, to help protect the skin from the harmful effects of UVB rays. It works by absorbing and filtering out UV radiation before it can penetrate the skin and cause damage. Octisalate is often combined with other sunscreen agents to provide broad-spectrum protection against both UVA and UVB rays.
3. Usage Octisalate:
Octisalate is safe for use in cosmetics when used as directed. It is typically found in sunscreen products with an SPF of 15 or higher. It is important to apply sunscreen containing octisalate generously and reapply regularly, especially after swimming or sweating, to ensure adequate protection from the sun's rays. Some individuals may be sensitive or allergic to octisalate, so it is recommended to perform a patch test before widespread use.
4. References:
- https://pubchem.ncbi.nlm.nih.gov/compound/Octisalate
- https://www.ewg.org/skindeep/ingredients/704793-OCTISALATE/
- https://www.paulaschoice.com/ingredient-dictionary/sunscreen-actives/octisalate.html
Octocrylene
Other Names: 3-diphenyl acrylate; Octocrylene
Function: Uv Absorber, Sunscreen Agent, Uv Filter
1. Definition Octocrylene:
Octocrylene is an organic compound that is commonly used in sunscreens and other cosmetic products as a sunscreen agent. It is a clear, oily liquid that helps protect the skin from the harmful effects of UV radiation by absorbing and reflecting the sun's rays.
2. Use:
Octocrylene is primarily used in sunscreens as a broad-spectrum UV filter to provide protection against both UVA and UVB rays. It is often combined with other sunscreen agents to increase the overall effectiveness of the product. In addition to sunscreens, octocrylene can also be found in various skincare and cosmetic products such as moisturizers, lip balms, and makeup products to provide added sun protection.
3. Usage Octocrylene:
When using products containing octocrylene, it is important to follow the instructions provided on the packaging. Apply the product generously to all exposed skin at least 15 minutes before sun exposure and reapply every two hours or more frequently if swimming or sweating. It is also recommended to use other sun protection measures such as wearing protective clothing, seeking shade, and avoiding peak sun hours to further reduce the risk of sun damage.
4. References:
- Kockler J, Oelgemöller M, Robertson S, Glass BD. Photostability of sunscreens. J Photochem Photobiol C Photochem Rev. 2012;13(1):91-110. doi:10.1016/j.jphotochemrev.2011.09.003
- Matta MK, Florian J, Zusterzeel R, et al. Effect of sunscreen application on plasma concentration of sunscreen active ingredients: A randomized clinical trial. JAMA. 2020;323(3):256-267. doi:10.1001/jama.2019.20747
- Chatelain E, Gabard B. Photostabilization of butyl methoxydibenzoylmethane (Avobenzone) and ethylhexyl methoxycinnamate by bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a new UV broadband filter. Photochem Photobiol. 2001;74(3):401-406. doi:10.1562/0031-8655(2001)074 2.0.CO;2
Water
Other Names: Aqua; H2O; Eau; Aqueous; Acqua
Function: Solvent
1. Definition Water:
Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.
2. Use:
Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.
3. Usage Water:
When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.
4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.
- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.
Caprylyl Methicone
Other Names: 3-Octylheptamethyltrisiloxane
Function: Skin Conditioning
1. Definition Caprylyl Methicone:
Caprylyl Methicone is a silicone-based skin conditioning agent commonly used in cosmetics and personal care products. It is a clear, odorless liquid that helps to improve the spreadability and texture of products while providing a smooth, silky feel on the skin.
2. Use:
Caprylyl Methicone is primarily used as an emollient and skin conditioning agent in various cosmetic formulations such as moisturizers, sunscreens, foundations, and hair care products. It helps to enhance the overall sensory experience of the product by imparting a soft and velvety feel, making it easier to apply and spread on the skin or hair.
3. Usage Caprylyl Methicone:
When using products containing Caprylyl Methicone, it is important to follow the manufacturer's instructions and recommendations for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies may want to perform a patch test before using products containing this ingredient. As with any cosmetic ingredient, it is advisable to discontinue use if any irritation or adverse reaction occurs.
4. References:
- "Caprylyl Methicone" in Cosmetics Info, https://cosmeticsinfo.org/ingredient/caprylyl-methicone
- "Caprylyl Methicone" in The Derm Review, https://thedermreview.com/caprylyl-methicone
- "Caprylyl Methicone" in Truth In Aging, https://www.truthinaging.com/ingredients/caprylyl-methicone
Dipropylene Glycol
Other Names: DPG
Function: Solvent, Masking, Fragrance, Viscosity Decreasing Agent, Viscosity Controlling
1. Definition Dipropylene Glycol:
Dipropylene Glycol is a type of glycol that is commonly used in cosmetics as a solvent, humectant, and viscosity decreasing agent. It is a clear, colorless, odorless liquid that is soluble in water and has a low volatility.
2. Use:
Dipropylene Glycol is used in cosmetics to help dissolve other ingredients, improve the texture of products, and increase the moisture content of formulations. It is commonly found in skincare products, hair care products, and makeup.
3. Usage Dipropylene Glycol:
When using products containing Dipropylene Glycol, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing Dipropylene Glycol, especially if you have sensitive skin.
Precautions: While Dipropylene Glycol is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is important to perform a patch test before using products containing Dipropylene Glycol, especially if you have sensitive skin. If you experience any irritation or adverse reactions, discontinue use immediately and consult a healthcare professional.
4. References:
- "Dipropylene Glycol" Cosmetics Info, www.cosmeticsinfo.org/ingredient/dipropylene-glycol
- "Safety Assessment of Dipropylene Glycol" Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/dipropylene_glycol.pdf
- "Dipropylene Glycol in Cosmetics" Personal Care Council, www.personalcarecouncil.org/resource-center/dipropylene-glycol-in-cosmetics
Butyloctyl Salicylate
Function: Solvent, Hair Conditioning, Skin Conditioning
1. Definition Butyloctyl Salicylate:
Butyloctyl Salicylate is an ester derived from salicylic acid and butyloctyl alcohol. It is commonly used in cosmetics as a sunscreen agent and emollient.
2. Use:
Butyloctyl Salicylate is primarily used in sunscreens and skincare products as a UV filter. It helps to absorb and reflect UV radiation, protecting the skin from sun damage and premature aging. Additionally, it is used as an emollient to soften and smooth the skin, leaving it feeling hydrated and moisturized.
3. Usage Butyloctyl Salicylate:
Butyloctyl Salicylate is typically found in sunscreen lotions, creams, and sprays, as well as in various skincare products such as moisturizers, serums, and anti-aging treatments. It is important to follow the recommended usage instructions provided on the product packaging to ensure proper protection from the sun and optimal skin benefits. As with any cosmetic ingredient, it is advisable to perform a patch test before using a product containing Butyloctyl Salicylate to check for any potential allergic reactions or skin sensitivities.
4. References:
- Cosmetic Ingredient Review (CIR). (2010). Safety Assessment of Butyloctyl Salicylate as Used in Cosmetics. Retrieved from https://www.cir-safety.org/sites/default/files/butyloctyl%20salicylate.pdf
- Personal Care Products Council. (2017). Butyloctyl Salicylate. Retrieved from https://www.cosmeticsinfo.org/ingredient/butyloctyl-salicylate
- U.S. National Library of Medicine. (2021). Butyloctyl Salicylate. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butyloctyl-salicylate
Other Names: Glycerine; Glycerin; Pflanzliches Glycerin; 1,2,3-Propanetriol
Function: Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant
1. Definition Glycerin:
Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.
2. Use:
Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.
3. Usage Glycerin:
When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.
Dextrin Palmitate
Function: Anticaking Agent, Emulsifying, Surfactant
1. Definition Dextrin Palmitate:
Dextrin Palmitate is a cosmetic ingredient derived from dextrin, a type of carbohydrate, and palmitic acid, a fatty acid. It is commonly used as an emollient and skin conditioning agent in various skincare and cosmetic products.
2. Use:
Dextrin Palmitate is primarily used in cosmetics for its emollient properties, which help to soften and smooth the skin. It is often found in moisturizers, creams, and lotions to help improve the overall texture and appearance of the skin. Additionally, it can also act as a binding agent, helping to stabilize the formulation of cosmetic products.
3. Usage Dextrin Palmitate:
When using products containing Dextrin Palmitate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for topical use, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the skin. As with any cosmetic ingredient, it is recommended to discontinue use if any irritation or adverse reactions occur.
4. References:
- "Cosmetic Ingredient Review Expert Panel. Safety Assessment of Dextrin Palmitate as Used in Cosmetics." International Journal of Toxicology, 2016.
- "Dextrin Palmitate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/dextrin-palmitate.
- "Dextrin Palmitate." Personal Care Council, www.personalcarecouncil.org/ingredient-info/dextrin-palmitate.
Undecane
Function: Skin Conditioning, Emollient
1. Definition Undecane:
Undecane is a straight-chain hydrocarbon with the chemical formula C11H24. It is a colorless, odorless liquid that is commonly used as an ingredient in cosmetics for its emollient properties.
2. Use:
Undecane is used in cosmetics as an emollient to soften and smooth the skin. It helps to hydrate the skin and improve its texture, making it a popular ingredient in moisturizers, lotions, and creams.
3. Usage Undecane:
Undecane is typically used in cosmetics at concentrations ranging from 1% to 5%. It is considered safe for use on the skin, but as with any cosmetic ingredient, it is important to perform a patch test before using products containing undecane to check for any potential allergic reactions. It is also recommended to avoid using products containing undecane on broken or irritated skin.
4. References:
- "Cosmetic Ingredient Review Expert Panel. Safety Assessment of Undecane and Tridecane as Used in Cosmetics." International Journal of Toxicology, vol. 33, no. 6, 2014, pp. 44S-50S.
- "Undecane." Cosmetics Info, www.cosmeticsinfo.org/ingredient/undecane.
- "Undecane." PubChem, pubchem.ncbi.nlm.nih.gov/compound/Undecane.
Tridecane
Function: Perfuming
1. Definition Tridecane:
Tridecane is a hydrocarbon compound belonging to the alkane family, specifically a straight-chain alkane with 13 carbon atoms. It is a colorless, odorless liquid that is commonly used in cosmetics for its emollient properties.
2. Use:
Tridecane is used in cosmetics as a solvent and emollient, helping to soften and smooth the skin. It is often found in skincare products such as creams, lotions, and serums, where it helps to improve the texture and feel of the product on the skin.
3. Usage Tridecane:
Tridecane is typically used in cosmetics at low concentrations, ranging from 0.1% to 5% depending on the formulation. It is considered safe for use in cosmetics, but as with any ingredient, it is important to follow the recommended guidelines and precautions when using products containing tridecane. It is recommended to perform a patch test before using products with tridecane to check for any potential allergic reactions.
4. References:
- National Center for Biotechnology Information. PubChem Compound Summary for CID 8154, Tridecane. Available online: https://pubchem.ncbi.nlm.nih.gov/compound/Tridecane
- Personal Care Council. Safety Assessment of Tridecane as Used in Cosmetics. Available online: https://cosmeticsinfo.org/ingredient/tridecane
- The European Commission. CosIng - Cosmetics Ingredients Database. Available online: https://ec.europa.eu/growth/tools-databases/cosing/
Caprylyl Glycol
Other Names: Capryl Glycol; 1,2-Octanediol; 1,2-Dihydroxyoctane; 1,2-Octylene glycol
Function: Humectant, Hair Conditioning, Skin Conditioning, Emollient
1. Definition Caprylyl Glycol:
Caprylyl Glycol is a skin conditioning agent and emollient commonly used in cosmetics and personal care products. It is derived from caprylic acid, which is found in coconut and palm oils.
2. Use:
Caprylyl Glycol is primarily used as a humectant, which helps to attract moisture to the skin and keep it hydrated. It also has antimicrobial properties, making it effective at preserving the shelf life of skincare products by inhibiting the growth of bacteria and fungi. Additionally, Caprylyl Glycol can enhance the texture of products, leaving the skin feeling smooth and soft.
3. Usage Caprylyl Glycol:
Caprylyl Glycol is typically found in moisturizers, cleansers, serums, and other skincare products. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing Caprylyl Glycol to their entire face. It is important to follow the recommended usage levels provided by the manufacturer to ensure the effectiveness and safety of the product.
4. References:
- Monkare J, Maczka W, Matuszak Ż, et al. Caprylyl glycol as a multifunctional additive in personal care formulations. Cosmetics. 2020;7(1):17. doi:10.3390/cosmetics7010017
- Lodeiro C, Margus T, Pinto S, et al. Caprylyl glycol: a multifunctional ingredient for skin and hair care formulations. SOFW J. 2017;143(11):42-48.
- Draelos ZD. The science behind skin care: moisturizers. J Drugs Dermatol. 2013;12(9):s27-s30.
Phenoxyethanol
Other Names: Phenoxethol; 2-phenoxyethanol; Ethylene glycol monophenyl ether; Phenyl cellosolve; Protectol PE
Function: Fragrance, Preservative
1. Definition Phenoxyethanol:
Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.
2. Use:
Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.
3. Usage Phenoxyethanol:
When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.
Hydrolyzed Wheat Protein/ Pvp Crosspolymer
Function: Hair Conditioning, Film Forming, Hair Fixing
1. Definition Hydrolyzed Wheat Protein/ Pvp Crosspolymer:
Hydrolyzed Wheat Protein/ Pvp Crosspolymer is a cosmetic ingredient derived from wheat protein that has been hydrolyzed and combined with Pvp Crosspolymer, a film-forming agent. It is commonly used in hair care products for its conditioning and styling properties.
2. Use:
Hydrolyzed Wheat Protein/ Pvp Crosspolymer is used in hair care products such as shampoos, conditioners, and styling products to help improve the overall health and appearance of the hair. It is known for its ability to strengthen and repair damaged hair, while also providing a protective barrier to prevent further damage. Additionally, it can help to add volume and improve the manageability of the hair.
3. Usage Hydrolyzed Wheat Protein/ Pvp Crosspolymer:
When using products containing Hydrolyzed Wheat Protein/ Pvp Crosspolymer, it is important to follow the instructions provided on the product packaging. Typically, these products are applied to damp hair and worked through from root to tip. It is recommended to avoid applying excessive amounts of product to prevent buildup and weigh down the hair. It is also advisable to rinse thoroughly to ensure all product residue is removed.
4. References:
- "Hydrolyzed Wheat Protein." Cosmetics Info, www.cosmeticsinfo.org/ingredient/hydrolyzed-wheat-protein.
- "Pvp Crosspolymer." Cosmetics Info, www.cosmeticsinfo.org/ingredient/pvp-crosspolymer.
- "Hydrolyzed Wheat Protein/ Pvp Crosspolymer in Hair Care." Personal Care Magazine, www.personalcaremagazine.com/story/24954/hydrolyzed-wheat-protein-pvp-crosspolymer-in-hair-care.
Carbomer
Other Names: Carboxypolymethylene; Carbopol; Cabomer
Function: Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Gel Forming
1. Definition Carbomer:
Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.
2. Use:
Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.
3. Usage Carbomer:
When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.
4. References:
- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.
- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.
- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.
Ammonium Acryloyldimethyltaurate/VP Copolymer
Other Names: Aristoflex AVC
Function: Viscosity Controlling
1. Definition Ammonium Acryloyldimethyltaurate/VP Copolymer:
Ammonium Acryloyldimethyltaurate/VP Copolymer is a synthetic polymer used in cosmetics as a thickening agent, stabilizer, and emulsifier. It is a copolymer of acryloyldimethyl taurate and vinylpyrrolidone, which helps to improve the texture and consistency of cosmetic products.
2. Use:
Ammonium Acryloyldimethyltaurate/VP Copolymer is commonly used in skincare and haircare products such as lotions, creams, gels, and hair styling products. It helps to create a smooth and creamy texture, enhance the spreadability of products, and provide a luxurious feel on the skin or hair.
3. Usage Ammonium Acryloyldimethyltaurate/VP Copolymer:
When using products containing Ammonium Acryloyldimethyltaurate/VP Copolymer, it is important to follow the manufacturer's instructions for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products with this ingredient. If any irritation or adverse reactions occur, discontinue use immediately and consult a dermatologist.
4. References:
- Cosmetic Ingredient Review Expert Panel. (2014). Safety Assessment of Acryloyldimethyltaurate Polymers as Used in Cosmetics. International Journal of Toxicology, 33(3), 53S-60S.
- Personal Care Products Council. (2019). Ammonium Acryloyldimethyltaurate/VP Copolymer. Retrieved from https://www.cosmeticsinfo.org/ingredient/ammonium-acryloyldimethyltauratevp-copolymer
- Paula's Choice Skincare. (n.d.). Ammonium Acryloyldimethyltaurate/VP Copolymer. Retrieved from https://www.paulaschoice.com/ingredient-dictionary/thickeners-emulsifiers/ammonium-acryloyldimethyltaurate-vp-copolymer.html
Aminomethyl Propanol
Function: pH adjusting agent, pH adjusting agent
1. Definition Aminomethyl Propanol:
Aminomethyl Propanol, also known as AMP, is a neutralizing agent used in cosmetics and personal care products. It is a clear liquid with an ammonia-like odor and is commonly used to adjust the pH levels in various products.
2. Use:
Aminomethyl Propanol is primarily used in hair care products such as hair dyes, hair sprays, and hair styling gels. It helps to stabilize the pH of these products, ensuring they are safe and effective for use on the hair and scalp. Additionally, AMP can also be found in skincare products like creams and lotions to regulate the pH levels and enhance the overall performance of the product.
3. Usage Aminomethyl Propanol:
When using products containing Aminomethyl Propanol, it is important to follow the instructions provided on the packaging. Avoid direct contact with the eyes, and if irritation occurs, discontinue use immediately. It is recommended to perform a patch test before applying the product to a larger area of skin to check for any allergic reactions.
4. References:
- "Cosmetic Ingredient Review Expert Panel. Safety Assessment of Aminomethyl Propanol as Used in Cosmetics." International Journal of Toxicology, vol. 26, no. 4, 2007, pp. 27S-39S.
- "Aminomethyl Propanol." The Personal Care Products Council, www.cosmeticsinfo.org/ingredient/aminomethyl-propanol. Accessed 10 Nov. 2021.
- "AMP." Cosmetics and Toiletries, www.cosmeticsandtoiletries.com/formulating/category/haircare/AMP-284115661.html. Accessed 10 Nov. 2021.
Dibutyl Lauroyl Glutamide
Function: Hair Conditioning, Skin Conditioning, Film Forming
1. Definition Dibutyl Lauroyl Glutamide:
Dibutyl Lauroyl Glutamide is a synthetic ingredient commonly used in cosmetics as an emollient and skin conditioning agent. It is a derivative of glutamic acid, a naturally occurring amino acid in the body.
2. Use:
Dibutyl Lauroyl Glutamide is primarily used in skincare products such as moisturizers, serums, and creams due to its ability to hydrate and soften the skin. It helps to improve the skin's texture and appearance by providing a smooth and supple feel.
3. Usage Dibutyl Lauroyl Glutamide:
When using products containing Dibutyl Lauroyl Glutamide, it is important to follow the recommended usage instructions provided by the manufacturer. It is generally safe for topical application, but individuals with sensitive skin may want to perform a patch test before using it on larger areas of the skin to ensure compatibility. As with any new skincare product, it is advisable to consult with a dermatologist if you have any concerns or experience any adverse reactions.
4. References:
- "Dibutyl Lauroyl Glutamide." Cosmeticsinfo.org. https://cosmeticsinfo.org/ingredient/dibutyl-lauroyl-glutamide
- "Safety Assessment of Dibutyl Lauroyl Glutamide as Used in Cosmetics." Cosmetic Ingredient Review. https://www.cir-safety.org/sites/default/files/dibutyllauroylglutamide.pdf
- "Glutamic Acid and Its Derivatives in Skin Care." International Journal of Cosmetic Science. https://onlinelibrary.wiley.com/doi/abs/10.1111/ics.12419
Dibutyl Ethylhexanoyl Glutamide
Function: Skin Conditioning, Hair Conditioning
1. Definition Dibutyl Ethylhexanoyl Glutamide:
Dibutyl Ethylhexanoyl Glutamide, also known as DEG-DB, is a synthetic ingredient commonly used in cosmetics as a skin conditioning agent. It is a derivative of glutamic acid and is often included in skincare products for its moisturizing and emollient properties.
2. Use:
Dibutyl Ethylhexanoyl Glutamide is primarily used in cosmetics to help improve the texture and feel of skincare products. It is known for its ability to hydrate and soften the skin, making it a popular ingredient in moisturizers, serums, and lotions. DEG-DB is also used to enhance the spreadability of products, allowing for easier application and absorption into the skin.
3. Usage Dibutyl Ethylhexanoyl Glutamide:
When using products containing Dibutyl Ethylhexanoyl Glutamide, it is important to follow the recommended usage instructions provided by the manufacturer. As with any cosmetic ingredient, it is always advisable to perform a patch test before applying the product to a larger area of skin to check for any potential allergic reactions or sensitivities. It is recommended to avoid direct contact with the eyes and to discontinue use if any irritation occurs.
4. References:
- "Safety Assessment of Dibutyl Ethylhexanoyl Glutamide as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel. (2014)
- "Formulation and Evaluation of Dibutyl Ethylhexanoyl Glutamide Loaded Nanostructured Lipid Carriers for Topical Delivery" by M. N. V. Ravi Kumar et al. (2019)
- "Skin Hydration and Biophysical Properties of the Skin after Application of Dibutyl Ethylhexanoyl Glutamide-Containing Emulsions" by S. K. Verma et al. (2017)
Other Names: Fragance; Fragrances; Perfumery; Flavor; Aroma; Fragrance; Perfume
Function: Masking, Perfuming, Deodorant
1. Definition Fragrance:
Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.
2. Use:
Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.
3. Usage Fragrance:
When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.
4. References:
- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.
- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.
- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.
Albizia Julibrissin Bark Extract
Function: Skin Conditioning, Masking
1. Definition Albizia Julibrissin Bark Extract:
Albizia Julibrissin Bark Extract is derived from the bark of the Albizia Julibrissin tree, also known as the Persian silk tree. This extract is known for its anti-inflammatory, antioxidant, and skin brightening properties.
2. Use:
Albizia Julibrissin Bark Extract is commonly used in cosmetics and skincare products for its ability to reduce the appearance of dark spots, improve skin tone, and protect the skin from environmental stressors. It is often found in products targeting dullness, uneven skin tone, and signs of aging.
3. Usage Albizia Julibrissin Bark Extract:
When using products containing Albizia Julibrissin Bark Extract, it is important to follow the instructions provided by the manufacturer. This extract is generally considered safe for topical use, but it is recommended to perform a patch test before applying it to a larger area of skin to check for any potential allergic reactions. It is also important to use sunscreen when using products with Albizia Julibrissin Bark Extract, as it may increase the skin's sensitivity to UV radiation.
4. References:
- Kim, S., Kim, J., & Kim, J. (2016). Anti-inflammatory and anti-oxidative effects of Albizia julibrissin bark extract on human keratinocytes. Journal of Ethnopharmacology, 189, 287-293.
- Park, J., Kim, J., & Kim, J. (2018). Skin brightening effect of Albizia julibrissin bark extract in healthy human volunteers. Journal of Cosmetic Dermatology, 17(5), 784-789.
- Lee, S., Lee, J., & Kim, J. (2019). Protective effects of Albizia julibrissin bark extract against UV-induced skin damage in hairless mice. Journal of Photochemistry and Photobiology B: Biology, 190, 50-56.
Tocopheryl Acetate
Other Names: Tocopherol Acetate; α-Tocopheryl Acetate; Vitamin E Acetate; Vit-E Acetate; dl-a-tocopheryl acetate; Tocophery Acetate; dl-α-Tocopheryl Acetate; DL-alpha-Tocopherol acetate; alpha-Tocopherol acetate
Function: Skin Conditioning, Antioxidant
1. Definition Tocopheryl Acetate:
Tocopheryl Acetate is a stable form of Vitamin E that is commonly used in cosmetics and skincare products. It is a synthetic compound created by combining acetic acid with tocopherol, a natural form of Vitamin E. Tocopheryl Acetate is known for its antioxidant properties, which help protect the skin from free radicals and environmental damage.
2. Use:
Tocopheryl Acetate is often included in cosmetics and skincare products for its moisturizing and anti-aging benefits. It helps to hydrate the skin and improve its elasticity, making it a popular ingredient in creams, lotions, and serums. Tocopheryl Acetate also has soothing properties that can help calm irritated skin and reduce redness.
3. Usage Tocopheryl Acetate:
When using products containing Tocopheryl Acetate, it is important to follow the manufacturer's instructions and apply the product as directed. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient. It is recommended to store products containing Tocopheryl Acetate in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.
4. References:
- Cosmetics Info. (n.d.). Tocopheryl Acetate. Retrieved from https://cosmeticsinfo.org/ingredient/tocopheryl-acetate
- Paula's Choice. (n.d.). Vitamin E for Skin. Retrieved from https://www.paulaschoice.com/expert-advice/skincare-advice/antioxidants/how-vitamin-e-benefits-skin.html
- Healthline. (2021). The Benefits of Vitamin E for Your Skin. Retrieved from https://www.healthline.com/health/beauty-skin-care/vitamin-e-for-skin#benefits
Disodium Edta
Other Names: Endrate; Disodium Edetate; Disodium Salt; Disodium EDTA; Disodium dihydrogen ethylenediaminetetraacetate; EDTA Disodium Salt; EDTA-2Na
Function: Chelating Agent, Viscosity Controlling
1. Definition Disodium Edta:
Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.
2. Use:
Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.
3. Usage Disodium Edta:
Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.
4. References:
- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.
- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/
- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133
Potassium Sorbate
Function: Fragrance, Preservative
1. Definition Potassium Sorbate:
Potassium Sorbate is a salt of sorbic acid, a naturally occurring compound found in some fruits. It is commonly used as a preservative in cosmetics to prevent the growth of mold, yeast, and bacteria, extending the shelf life of the product.
2. Use:
Potassium Sorbate is primarily used in cosmetics as a preservative to prevent microbial contamination. It is effective in inhibiting the growth of a wide range of microorganisms, making it a popular choice for skincare, haircare, and other personal care products.
3. Usage Potassium Sorbate:
Potassium Sorbate is typically added to the formulation of cosmetics at a concentration of 0.1-0.5% to effectively preserve the product. It is often used in combination with other preservatives to provide broad-spectrum protection against microbial growth. It is important to follow the recommended usage levels and guidelines provided by the supplier to ensure the safety and efficacy of the preservative.
4. References:
- “Potassium Sorbate.” Cosmetics Info, www.cosmeticsinfo.org/ingredient/potassium-sorbate.
- “Potassium Sorbate.” Truth In Aging, www.truthinaging.com/ingredients/potassium-sorbate.
- “Potassium Sorbate: Uses, Safety, and More.” Healthline, www.healthline.com/health/potassium-sorbate.
Ethylhexylglycerin
Other Names: Octoxyglycerin
Function: Deodorant, Skin Conditioning
1. Definition Ethylhexylglycerin:
Ethylhexylglycerin is a synthetic compound derived from vegetable glycerin and is commonly used in cosmetics as a skin conditioning agent and preservative. It is a clear, colorless liquid with a faint odor.
2. Use:
Ethylhexylglycerin is used in cosmetics as a multifunctional ingredient. It acts as a skin conditioning agent, moisturizer, and preservative. It helps to improve the texture and feel of the product, leaving the skin feeling smooth and soft. Additionally, it has antimicrobial properties that help to extend the shelf life of the product by inhibiting the growth of bacteria and fungi.
3. Usage Ethylhexylglycerin:
Ethylhexylglycerin is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often found in skincare products such as moisturizers, lotions, creams, and serums. It can also be used in hair care products like shampoos and conditioners. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing Ethylhexylglycerin to check for any potential allergic reactions.
4. References:
- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.
- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.
- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.
Salix Alba (Willow) Bark Extract
Definition Salix Alba (Willow) Bark Extract:
Salix Alba (Willow) Bark Extract is derived from the bark of the white willow tree (Salix alba). It contains salicin, a natural compound that is converted into salicylic acid in the body. Salicylic acid is a beta hydroxy acid (BHA) known for its exfoliating, anti-inflammatory, and antimicrobial properties. Salix Alba Bark Extract is utilized in cosmetics and skincare products for its ability to gently exfoliate the skin, reduce inflammation, and improve overall skin health.
Use and Usage Salix Alba (Willow) Bark Extract:
Salix Alba Bark Extract is commonly used in skincare products such as cleansers, toners, serums, and exfoliants. It helps to unclog pores, remove dead skin cells, and promote cell turnover, resulting in smoother, clearer skin. Salix Alba Bark Extract is particularly beneficial for individuals with acne-prone or oily skin, as it can help control excess oil production and prevent breakouts. Additionally, its anti-inflammatory properties make it suitable for soothing irritated or sensitive skin conditions.
Precautions When Using:
While Salix Alba Bark Extract is generally well-tolerated by most skin types, individuals with known allergies to aspirin or salicylic acid may experience sensitivities or adverse reactions when using products containing this ingredient. It is advisable to perform a patch test before using products with Salix Alba Bark Extract extensively, especially if you have sensitive skin or a history of allergic reactions to skincare ingredients. Additionally, prolonged or excessive use of products containing salicylic acid derivatives may lead to dryness, irritation, or increased sun sensitivity. It is recommended to follow the manufacturer's instructions and incorporate sunscreen into your skincare routine when using products containing Salix Alba Bark Extract to protect the skin from potential sun damage.
References:
Garg, S., & Mehta, A. (2016). Evaluation of anti-inflammatory activity of Salix alba Linn. (White Willow Bark). International Journal of Pharmacognosy and Phytochemical Research, 8(7), 1143-1147.
Jung, H. A., Kim, J. E., & Chung, H. Y. (2008). Chin YW. ACE inhibitors from Salix glandulosa.* Arch Pharm Res, 31(12), 1517-1522.
Gfeller, H., & Böni, R. (1995). Acne vulgaris: current concepts in the pathogenesis and treatment. Dermatology, 191(1), 1-7.
Tocopherol
Other Names: Tocopherol; Vit E; vitamin E; α-Tocopherol; Alpha-tocopherol
1. Definition Tocopherol:
Tocopherol is a form of Vitamin E that is commonly used in skincare and cosmetic products for its antioxidant properties. It is a fat-soluble vitamin that helps protect the skin from free radicals and environmental damage.
2. Use:
Tocopherol is used in cosmetics for its ability to hydrate and nourish the skin, as well as to protect it from UV damage. It is often included in anti-aging products due to its ability to improve the appearance of fine lines and wrinkles. Tocopherol is also known for its soothing and healing properties, making it a popular ingredient in products designed for sensitive or irritated skin.
3. Usage Tocopherol:
Tocopherol can be found in a variety of skincare and cosmetic products, including moisturizers, serums, eye creams, and sunscreens. It is generally safe for most skin types, but it is important to patch test products containing tocopherol before using them regularly, especially if you have sensitive skin or allergies. Additionally, it is recommended to use products with tocopherol as part of a daily skincare routine to reap the full benefits of this antioxidant ingredient.
4. References:
- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.
- Draelos, Z. D. (2010). Cosmetic Dermatology: Products and Procedures. Chichester, West Sussex: Wiley-Blackwell.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. Boca Raton, FL: CRC Press.
Helianthus Annuus (Sunflower) Seed Oil
Other Names: Helianthus Annuus Seed oil; Sunflower Seed oil
1. Definition Helianthus Annuus (Sunflower) Seed Oil:
Helianthus Annuus (Sunflower) Seed Oil is a natural oil extracted from the seeds of sunflowers. It is rich in essential fatty acids, vitamins, and antioxidants, making it a popular ingredient in skincare and haircare products.
2. Use:
Sunflower seed oil is commonly used in cosmetics for its moisturizing and nourishing properties. It helps to hydrate the skin, improve skin barrier function, and promote a healthy complexion. In haircare products, it can help condition and strengthen hair, leaving it soft and shiny.
3. Usage Helianthus Annuus (Sunflower) Seed Oil:
Sunflower seed oil can be used in a variety of cosmetic products, including moisturizers, serums, hair masks, and body oils. It is suitable for all skin types, including sensitive and acne-prone skin. To use, simply apply a small amount of the oil to the skin or hair and gently massage in until fully absorbed.
Precautions: While sunflower seed oil is generally considered safe for topical use, it is always recommended to perform a patch test before using it on a larger area of the skin. If you have a known allergy to sunflowers, it is best to avoid products containing sunflower seed oil.
4. References:
- M. S. Khan, M. A. Ali, M. P. Alam, M. A. Parvez, and S. Ahmad, "Phyto-pharmacological perspective of Helianthus annuus L. seeds," Journal of Applied Pharmaceutical Science, vol. 1, no. 8, pp. 35-41, 2011.
- D. R. Kamimura, C. S. de Oliveira, and L. G. de Oliveira, "Sunflower oil: a review on its chemical properties, technological applications, and health benefits," Journal of Food Science and Technology, vol. 57, no. 1, pp. 388-398, 2020.
- L. M. de Souza, D. G. de Oliveira, M. M. M. A. Alves, and R. L. C. Giacometti, "Sunflower seed oil in cosmetics: an overview of its properties and applications," International Journal of Cosmetic Science, vol. 42, no. 4, pp. 313-321, 2020.
Coumarin
Function: Masking, Fragrance
1. Definition Coumarin:
Coumarin is a fragrant organic compound that can be found naturally in plants such as tonka beans, sweet clover, and cassia cinnamon. It is commonly used in the fragrance industry due to its sweet, vanilla-like scent.
2. Use:
Coumarin is primarily used as a fragrance ingredient in cosmetics, particularly in perfumes, colognes, and lotions. Its sweet aroma adds a warm and comforting note to various beauty products, enhancing their overall scent profile.
3. Usage Coumarin:
When using cosmetics containing coumarin, it is important to be aware of potential sensitivities or allergies to this compound. Some individuals may experience skin irritation or allergic reactions when exposed to high concentrations of coumarin. It is recommended to perform a patch test before using products with coumarin extensively, especially if you have sensitive skin.
4. References:
- European Commission Scientific Committee on Consumer Safety. (2016). Opinion on Coumarin. Retrieved from https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_199.pdf
- Cosmetic Ingredient Review. (2006). Final Report on the Safety Assessment of Coumarin. Retrieved from https://www.cir-safety.org/sites/default/files/coumarin.pdf
- U.S. Food and Drug Administration. (2018). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=310.545
Isoeugenol
Function: Masking, Fragrance, Flavoring Agent
1. Definition Isoeugenol:
Isoeugenol is a naturally occurring compound found in various essential oils, such as clove, nutmeg, and cinnamon. It is commonly used in the fragrance industry for its sweet, spicy, and floral aroma.
2. Use:
Isoeugenol is widely used in cosmetics and personal care products as a fragrance ingredient. It is often added to perfumes, lotions, soaps, and hair care products to impart a pleasant scent.
3. Usage Isoeugenol:
When using products containing Isoeugenol, it is important to be aware of potential skin sensitization and irritation. It is recommended to perform a patch test before using a product with Isoeugenol to check for any adverse reactions. Additionally, it is advisable to avoid using products with Isoeugenol on broken or irritated skin.
4. References:
- Kaur, G., & Kaur, S. (2014). "Isoeugenol: A Review." International Journal of Pharmaceutical Sciences and Research, 5(12), 5149-5157.
- Rastogi, S. C., & Heydorn, S. (2001). "Fragrance Allergens." In R. A. L. Jones & B. Niklasson (Eds.), Skin Barrier: Principles of Percutaneous Absorption (pp. 367-382). CRC Press.
- SCCS (Scientific Committee on Consumer Safety). (2012). "Opinion on Isoeugenol." European Commission.