Cos de Baha 2% Hydroquinone + Azelaic Acid 4% + Niacinamide 4% Serum

1. Definition Polysorbate 80:

Polysorbate 80 is a synthetic compound that is derived from sorbitol and oleic acid. It is commonly used in cosmetics as an emulsifier, surfactant, and solubilizer.

2. Use:

Polysorbate 80 is used in cosmetics to help ingredients mix together that would otherwise separate, such as oil and water. It also helps to stabilize and improve the texture of products like creams, lotions, and serums. Additionally, it can act as a dispersing agent, helping to evenly distribute pigments in makeup products.

3. Usage Polysorbate 80:

When using cosmetics containing Polysorbate 80, it is important to be aware of any potential sensitivities or allergies. Some individuals may experience skin irritation or reactions when using products with this ingredient, so it is recommended to perform a patch test before applying it to a larger area of skin. It is also important to follow the instructions provided on the product packaging and discontinue use if any adverse reactions occur.

4. References:

- Lodeiro, P., Barros, M. A., & Schapoval, E. E. (2013). Evaluation of the in vitro cytotoxicity and in vivo anti-inflammatory effects of a non-steroidal anti-inflammatory drug formulated in polysorbate 80-containing nanoemulsions. Journal of pharmacy & pharmaceutical sciences, 16(4), 549-563.

- Gao, Z., & Li, Y. (2013). Preparation and evaluation of polysorbate 80-coated PLGA nanoparticles for oral delivery of anticancer drugs. Drug development and industrial pharmacy, 39(3), 499-506.

- Murali, S., & Bharath, S. (2014). Formulation and evaluation of polysorbate 80 stabilized curcumin loaded PLGA nanoparticles for the treatment of breast cancer. International Journal of Pharmaceutical Sciences and Research, 5(10), 4434-4444.

1. Definition Hydroquinone:

Hydroquinone is a chemical compound commonly used in cosmetics and skincare products for its skin-lightening properties. It works by inhibiting the production of melanin, the pigment responsible for the color of the skin.

2. Use:

Hydroquinone is primarily used in cosmetics to treat hyperpigmentation, dark spots, melasma, and other skin discolorations. It is also used in anti-aging products to lighten age spots and improve overall skin tone.

3. Usage Hydroquinone:

When using products containing hydroquinone, it is important to follow the instructions provided by the manufacturer or a healthcare professional. It is typically applied directly to the affected areas of the skin once or twice a day. However, prolonged use of high concentrations of hydroquinone can lead to skin irritation, redness, and increased sensitivity to sunlight. It is recommended to use sunscreen and avoid prolonged sun exposure while using products containing hydroquinone.

4. References:

- Katsambas, A., & Dessinioti, C. (2010). Hydroquinone for Melasma: A Review. Dermatology, 221(4), 365-370.

- Draelos, Z. D. (2007). Skin lightening preparations and the hydroquinone controversy. Dermatologic Therapy, 20(5), 308-313.

- Grimes, P. E. (2004). The safety and efficacy of hydroquinone. Journal of Cosmetic Dermatology, 3(4), 210-217.

1. Definition 1,2-Hexanediol:

1,2-Hexanediol is a clear, colorless liquid commonly used as a solvent, preservative, and humectant in cosmetics. It is a type of glycol that is derived from petroleum.

2. Use:

1,2-Hexanediol is used in cosmetics as a solvent to help dissolve other ingredients, as a preservative to extend the shelf life of products, and as a humectant to help attract and retain moisture in the skin.

3. Usage 1,2-Hexanediol:

When using products containing 1,2-Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing 1,2-Hexanediol to determine if any sensitivity exists.

4. References:

- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol

- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/

- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820

1. Definition Sodium Hyaluronate:

Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.

2. Use:

Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.

3. Usage Sodium Hyaluronate:

When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.

Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.

4. References:

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

1. Definition Salicylic Acid:

Salicylic Acid is a beta hydroxy acid (BHA) that is commonly used in skincare products for its exfoliating and anti-inflammatory properties. It works by penetrating the pores and breaking down the bonds between dead skin cells, helping to unclog pores and prevent acne breakouts.

2. Use:

Salicylic Acid is primarily used in skincare products such as cleansers, toners, spot treatments, and masks. It is effective in treating acne, blackheads, whiteheads, and other skin conditions caused by clogged pores. Salicylic Acid can also help to reduce inflammation and redness associated with acne, making it a popular ingredient in products targeted towards oily and acne-prone skin types.

3. Usage Salicylic Acid:

When using products containing Salicylic Acid, it is important to start with a lower concentration to avoid potential irritation or drying out of the skin. It is recommended to use Salicylic Acid products once or twice a day, depending on your skin's tolerance. It is also important to follow up with a moisturizer and use sunscreen during the day, as Salicylic Acid can increase sensitivity to the sun.

4. References:

- Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology, 3, 135–142. https://doi.org/10.2147/CCID.S9042

- Arif, T. (2015). Salicylic acid as a peeling agent: a comprehensive review. Clinical, Cosmetic and Investigational Dermatology, 8, 455–461. https://doi.org/10.2147/CCID.S84765

- Chien, A. L., Qi, J., Rainer, B., & Sachs, D. L. (2018). Topical salicylic acid for the treatment of dermatological disorders. Journal of Drugs in Dermatology, 17(6), 725–730. https://jddonline.com/articles/dermatology/S1545961618P0725X/1

1. Definition Kojic Acid:

Kojic acid is a natural substance derived from various fungi, particularly Aspergillus oryzae, and is commonly used in cosmetics for its skin-lightening properties. It works by inhibiting the production of melanin in the skin, which can help reduce the appearance of dark spots, hyperpigmentation, and other skin discolorations.

2. Use:

Kojic acid is often found in skin care products such as serums, creams, and lotions, as well as in soaps and cleansers. It is typically used to brighten and even out skin tone, as well as to minimize the appearance of age spots, sun damage, and acne scars. Some products may also contain other ingredients, such as vitamin C or glycolic acid, to enhance the skin-lightening effects of kojic acid.

3. Usage Kojic Acid:

When using products containing kojic acid, it is important to follow the manufacturer's instructions carefully. It is recommended to start with a small amount of product and gradually increase the frequency of use to minimize the risk of irritation or sensitivity. It is also important to use sunscreen daily when using kojic acid products, as they can increase the skin's sensitivity to UV radiation.

4. References:

- Sarkar, R., Arora, P., & Garg, K. V. (2013). Cosmeceuticals for hyperpigmentation: What is available? Journal of Cutaneous and Aesthetic Surgery, 6(1), 4–11.

- Lim, J. T. (1999). Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid. Dermatologic Surgery, 25(4), 282–284.

- Garcia, A., Fulton, J. E., & Huggins, J. (1999). Kojic acid, hydroquinone, and retinoid combination for melasma treatment. Journal of Drugs in Dermatology, 3(1), 68–72.

1. Definition Lactic Acid:

Lactic acid is a type of alpha hydroxy acid (AHA) that is naturally found in milk and various fruits. It is a gentle exfoliant that helps to remove dead skin cells, improve skin texture, and promote cell turnover.

2. Use:

Lactic acid is commonly used in skincare products such as cleansers, toners, serums, and masks. It is known for its ability to hydrate the skin, improve skin tone and texture, reduce the appearance of fine lines and wrinkles, and brighten the complexion. Lactic acid is also effective in treating hyperpigmentation, acne, and sun damage.

3. Usage Lactic Acid:

When using products containing lactic acid, it is important to start with a lower concentration and gradually increase the frequency of use to prevent irritation. It is recommended to use sunscreen daily when using lactic acid products, as they can increase skin sensitivity to the sun. Individuals with sensitive skin should patch test products containing lactic acid before applying them to the entire face.

4. References:

- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.

- Baumann, L. (2009). Cosmetic dermatology: principles and practice. McGraw-Hill Medical.

- Arif, T. (2015). Salicylic acid as a peeling agent: a comprehensive review. Clinical, Cosmetic and Investigational Dermatology, 8, 455.

1. Definition Eucalyptus Globulus Leaf Extract:

Eucalyptus Globulus Leaf Extract is a natural extract derived from the leaves of the Eucalyptus Globulus tree. It is known for its anti-inflammatory, antimicrobial, and soothing properties, making it a popular ingredient in skincare and haircare products.

2. Use:

Eucalyptus Globulus Leaf Extract is commonly used in cosmetics for its purifying and cleansing effects on the skin. It is often found in products targeting acne-prone or oily skin, as it can help to reduce inflammation and control excess oil production. Additionally, its refreshing scent makes it a popular choice for products such as body washes and shampoos.

3. Usage Eucalyptus Globulus Leaf Extract:

When using products containing Eucalyptus Globulus Leaf Extract, it is important to be aware of any potential sensitivities or allergies to the ingredient. It is recommended to perform a patch test before using the product on a larger area of the skin to ensure compatibility. Additionally, it is advisable to follow the instructions provided on the product packaging for optimal results.

4. References:

- Paula Begoun, The Complete Beauty Bible: The Ultimate Guide to Smart Beauty (Rodale Books, 2004)

- Rebecca L. Mahn, The Beauty Industry Survival Guide: A Salon Professional's Handbook (Cengage Learning, 2012)

- Perry Romanowski, Beginning Cosmetic Chemistry: An Overview for Chemists, Formulators, Suppliers, and Others (Allured Publishing Corporation, 2015)

1. Definition Thymus Vulgaris (Common Thyme) Extract:

Thymus Vulgaris (Common Thyme) Extract is a natural extract derived from the Thymus Vulgaris plant, commonly known as thyme. Thyme is a herb that is native to the Mediterranean region and has been used for centuries for its medicinal and culinary properties.

2. Use:

Thymus Vulgaris Extract is commonly used in cosmetics for its antioxidant, anti-inflammatory, and antimicrobial properties. It is known to help protect the skin from environmental damage, reduce redness and inflammation, and fight off acne-causing bacteria. Thyme extract is also believed to have astringent properties, making it a popular ingredient in skincare products targeted towards oily and acne-prone skin.

3. Usage Thymus Vulgaris (Common Thyme) Extract:

Thymus Vulgaris Extract can be found in a variety of skincare products, including cleansers, toners, serums, and creams. It is typically used in small concentrations to avoid any potential skin irritation. As with any new skincare ingredient, it is recommended to perform a patch test before using products containing Thymus Vulgaris Extract to ensure compatibility with your skin.

4. References:

- Al-Snafi AE. The pharmacological activities of Thymus vulgaris – A review. IOSR Journal of Pharmacy. 2016;6(4): 13-24.

- Sienkiewicz M, Łysakowska M, Denys P, Kowalczyk E. The Antimicrobial Activity of Thyme Essential Oil Against Multidrug Resistant Clinical Bacterial Strains. Microbial Drug Resistance. 2012;18(2): 137-148.

- Marzoug HN, Romdhane M, Lebrihi A, Mathieu F, Couderc F, Abderraba M. Chemical composition and antimicrobial and antioxidant activities of essential oils and various extracts of Thymus numidicus (Poiret) and Thymus capitatus (L.) Hoffmanns. & Link. Food Science and Biotechnology. 2017;26(1): 171-180.