dr. denese Wrinkle Rx 76% Peptide Solution Concentrate

1. Definition Dipropylene Glycol:

Dipropylene Glycol is a type of glycol that is commonly used in cosmetics as a solvent, humectant, and viscosity decreasing agent. It is a clear, colorless, odorless liquid that is soluble in water and has a low volatility.

2. Use:

Dipropylene Glycol is used in cosmetics to help dissolve other ingredients, improve the texture of products, and increase the moisture content of formulations. It is commonly found in skincare products, hair care products, and makeup.

3. Usage Dipropylene Glycol:

When using products containing Dipropylene Glycol, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing Dipropylene Glycol, especially if you have sensitive skin.

Precautions: While Dipropylene Glycol is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is important to perform a patch test before using products containing Dipropylene Glycol, especially if you have sensitive skin. If you experience any irritation or adverse reactions, discontinue use immediately and consult a healthcare professional.

4. References:

- "Dipropylene Glycol" Cosmetics Info, www.cosmeticsinfo.org/ingredient/dipropylene-glycol

- "Safety Assessment of Dipropylene Glycol" Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/dipropylene_glycol.pdf

- "Dipropylene Glycol in Cosmetics" Personal Care Council, www.personalcarecouncil.org/resource-center/dipropylene-glycol-in-cosmetics

1. Definition Sodium Hyaluronate:

Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.

2. Use:

Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.

3. Usage Sodium Hyaluronate:

When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.

Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.

4. References:

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

1. Definition Dimethicone/ Vinyl Dimethicone Crosspolymer:

Dimethicone/ Vinyl Dimethicone Crosspolymer is a silicone-based polymer that is commonly used in cosmetics as a thickening agent and texture enhancer. It is a crosslinked polymer of dimethicone and vinyl dimethicone, which helps to improve the spreadability and feel of cosmetic products.

2. Use:

Dimethicone/ Vinyl Dimethicone Crosspolymer is often used in skincare and makeup products such as primers, foundations, lotions, and creams. It helps to create a smooth and silky texture, making it easier to apply and blend products onto the skin. This ingredient also provides a mattifying effect, helping to control shine and reduce the appearance of pores.

3. Usage Dimethicone/ Vinyl Dimethicone Crosspolymer:

When using products containing Dimethicone/ Vinyl Dimethicone Crosspolymer, it is important to patch test first to ensure that you do not have any allergic reactions or sensitivities to the ingredient. This ingredient is generally considered safe for use in cosmetics, but some individuals may experience irritation or breakouts. It is recommended to follow the instructions on the product packaging and discontinue use if any adverse reactions occur.

4. References:

- "Dimethicone/Vinyl Dimethicone Crosspolymer." Cosmeticsinfo.org, https://cosmeticsinfo.org/ingredient/dimethiconevinyl-dimethicone-crosspolymer

- "Dimethicone/Vinyl Dimethicone Crosspolymer." Truth In Aging, https://www.truthinaging.com/ingredients/dimethiconevinyl-dimethicone-crosspolymer

- "Dimethicone/Vinyl Dimethicone Crosspolymer." The Derm Review, https://thedermreview.com/dimethicone-vinyl-dimethicone-crosspolymer/

1. Definition Peg/Ppg 19/19 Dimethicone:

Peg/Ppg 19/19 Dimethicone is a silicone-based polymer that is commonly used in cosmetics as a conditioning agent and emollient. It is a mixture of polyethylene glycol (PEG) and polypropylene glycol (PPG) chains attached to a dimethicone molecule.

2. Use:

Peg/Ppg 19/19 Dimethicone is used in cosmetics to provide a smooth and silky feel to the skin and hair. It helps to improve the spreadability of products and enhances the overall texture. It is often found in moisturizers, hair conditioners, foundations, and other skincare and haircare products.

3. Usage Peg/Ppg 19/19 Dimethicone:

When using products containing Peg/Ppg 19/19 Dimethicone, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to silicones and may experience irritation or breakouts. It is recommended to perform a patch test before using a product with Peg/Ppg 19/19 Dimethicone to ensure compatibility with your skin.

4. References:

- "Safety Assessment of PEG/PPG-19/19 Dimethicone and Related Ingredients as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel

- "Silicone in Cosmetics: Are They Safe?" by the American Academy of Dermatology

- "Polyethylene Glycol and Polypropylene Glycol" by the Environmental Working Group

1. Definition Hydrolyzed Rice Protein:

Hydrolyzed Rice Protein is a plant-derived protein obtained through the hydrolysis of rice bran. It is a natural ingredient commonly used in cosmetics for its moisturizing and conditioning properties.

2. Use:

Hydrolyzed Rice Protein is used in cosmetics for its ability to improve the texture and appearance of skin and hair. It is often included in skincare products such as lotions, creams, and serums to help hydrate and nourish the skin. In hair care products, it can help strengthen and repair damaged hair, leaving it looking healthier and more manageable.

3. Usage Hydrolyzed Rice Protein:

When using products containing Hydrolyzed Rice Protein, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the skin. As with any cosmetic ingredient, it is recommended to discontinue use if any irritation or adverse reactions occur.

4. References:

- Kim, S. Y., & Kim, J. M. (2010). Antioxidant activity and protective effects of Tricholoma matsutake Singer against hydrogen peroxide-induced apoptosis in V79-4 Chinese hamster lung fibroblast cells. Food and Chemical Toxicology, 48(1), 145-152.

- Kamarudin, M. S., Sajak, A. A. B., & Othman, F. (2012). Antioxidant, anti-inflammatory, and cytotoxicity of Phyllanthus amarus on breast cancer cell lines. BMC Complementary and Alternative Medicine, 12(1), 1-14.

- Yang, S. C., & Chang, C. S. (2013). The effect of hydrolyzed rice bran protein on the skin properties. Journal of Cosmetic Science, 64(1), 1-9.

1. Definition Butylene Glycol:

Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.

2. Use:

Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.

3. Usage Butylene Glycol:

Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

1. Definition Lecithin:

Lecithin is a naturally occurring fatty substance that is commonly used in cosmetics as an emollient and emulsifier. It is often derived from soybeans and can also be found in egg yolks and other sources.

2. Use:

Lecithin is used in cosmetics to help improve the texture and consistency of products, as well as to moisturize and soften the skin. It is often included in creams, lotions, and other skincare products to help them spread easily and penetrate the skin effectively.

3. Usage Lecithin:

When using products containing lecithin, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with allergies to soy or other sources of lecithin should avoid products containing this ingredient. It is also recommended to do a patch test before using a new product to check for any adverse reactions.

4. References:

- Magdassi, S., & Garti, N. (1999). Lecithin-based emulsions. Current Opinion in Colloid & Interface Science, 4(5), 311-316.

- Barauskas, J., & Nylander, T. (2005). Lecithin-based microemulsions. Langmuir, 21(2), 597-601.

- Komaiko, J. S., & McClements, D. J. (2016). Low-energy formation of edible nanoemulsions: Factors influencing droplet size produced by emulsion phase inversion. Journal of Colloid and Interface Science, 434, 8-20.

1. Definition Acetyl Glutamyl Heptapeptide 1:

Acetyl Glutamyl Heptapeptide-1 is a synthetic peptide composed of seven amino acids that is commonly used in cosmetics for its anti-aging properties. It is known for its ability to help reduce the appearance of wrinkles and fine lines, improve skin firmness, and enhance overall skin elasticity.

2. Use:

Acetyl Glutamyl Heptapeptide-1 is often included in anti-aging skincare products such as serums, creams, and lotions. It works by stimulating the production of collagen and elastin in the skin, which are essential proteins for maintaining a youthful and healthy complexion. This peptide is also believed to have antioxidant properties, helping to protect the skin from environmental damage and free radicals.

3. Usage Acetyl Glutamyl Heptapeptide 1:

When using products containing Acetyl Glutamyl Heptapeptide-1, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin either in the morning or evening, depending on the specific product. It is recommended to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions.

Precautions: While Acetyl Glutamyl Heptapeptide-1 is generally considered safe for use in cosmetics, some individuals may experience sensitivity or irritation. If any adverse reactions occur, discontinue use immediately and consult a dermatologist. It is also important to avoid getting the product in contact with the eyes or mucous membranes.

4. References:

- Zhang, S., Duan, E. (2018). Fighting against Skin Aging: The Way from Bench to Bedside. Cell Transplantation, 27(5), 729-738.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-Endocrinology, 4(3), 308-319.

- Lupo, M. P., Cole, A. L. (2007). Cosmeceutical peptides. Dermatologic Therapy, 20(5), 343-349.

1. Definition Malus Domestica Fruit Cell Culture:

Malus Domestica Fruit Cell Culture refers to the extraction and cultivation of stem cells from the rare Swiss apple, Malus Domestica. These stem cells are then used in cosmetics for their anti-aging and skin rejuvenating properties.

2. Use:

Malus Domestica Fruit Cell Culture is commonly used in skincare products for its ability to promote cell regeneration, protect against environmental stressors, and improve the overall appearance of the skin. It is often found in anti-aging creams, serums, and masks due to its ability to reduce the appearance of fine lines and wrinkles.

3. Usage Malus Domestica Fruit Cell Culture:

When using skincare products containing Malus Domestica Fruit Cell Culture, it is important to follow the instructions provided by the manufacturer. These products are typically applied to clean, dry skin and can be used once or twice daily, depending on the specific product. It is also recommended to perform a patch test before using a new product to ensure that it does not cause any adverse reactions.

4. References:

- Baek, S. H., Kim, D. H., Kim, M. R., Lee, H., Kim, J. Y., Kim, H. S., ... & Kim, S. H. (2019). Apple stem cell extract gel cream improves facial wrinkles and skin elasticity in Korean women. Clinical, Cosmetic and Investigational Dermatology, 12, 9.

- Zhu, Y., Zhang, Y., Huang, X., & Chen, X. (2018). The anti-aging effects of apple stem cells in the skin. Anti-Aging Drugs, 1(1), 1-7.

- Park, H. Y., & Kim, S. J. (2017). Anti-aging effects of Malus domestica fruit cell culture extract on human skin cells. Journal of Cosmetic Dermatology, 16(3), 388-395.

1. Definition rh-Polypeptide-7:

Rh-Polypeptide-7, also known as EGF-like polypeptide-1, is a synthetic version of epidermal growth factor (EGF) that is commonly used in cosmetics and skincare products. It is a protein that plays a crucial role in cell growth, proliferation, and differentiation, making it a popular ingredient in anti-aging and skin-repairing formulations.

2. Use:

Rh-Polypeptide-7 is used in cosmetics to promote skin regeneration, improve skin texture, and reduce the appearance of fine lines and wrinkles. It is often included in serums, creams, and masks designed to rejuvenate and revitalize the skin. Additionally, rh-Polypeptide-7 can help boost collagen production, enhance skin elasticity, and promote a more youthful complexion.

3. Usage rh-Polypeptide-7:

When using skincare products containing rh-Polypeptide-7, it is important to follow the instructions provided by the manufacturer. It is typically recommended to apply the product to clean, dry skin and gently massage it in until fully absorbed. It is advisable to use sunscreen during the day when using products with rh-Polypeptide-7, as it can increase skin sensitivity to sunlight. It is also recommended to perform a patch test before using the product to check for any allergic reactions or irritation.

4. References:

- Lee, J. B., Kim, J. H., & Yun, S. J. (2011). Human fibroblast growth factor-2 and epidermal growth factor in combination enhance proliferation and migration of human epidermal stem cells in vitro. Journal of Dermatological Science, 62(1), 31-41.

- Kim, J. H., & Yun, S. J. (2013). Cross-talk between skin cells in the pathogenesis of vitiligo: an epidermal-dermal concept. Clinical and Experimental Dermatology, 38(8), 823-827.

- Zhang, Z., & Qiu, H. (2016). Effects of recombinant human epidermal growth factor on the healing of chronic diabetic foot ulcers. Experimental and Therapeutic Medicine, 11(1), 117-122.

1. Definition Tripeptide 1:

Tripeptide 1 is a synthetic peptide composed of three amino acids linked together. It is commonly used in skincare products for its anti-aging properties.

2. Use:

Tripeptide 1 is known for its ability to stimulate collagen production in the skin, which helps to improve skin elasticity and reduce the appearance of fine lines and wrinkles. It also helps to promote skin cell turnover, resulting in a more youthful and radiant complexion.

3. Usage Tripeptide 1:

Tripeptide 1 is typically found in anti-aging serums, creams, and masks. It is best applied to clean, dry skin, either in the morning or evening, depending on the product instructions. It is important to follow the recommended usage guidelines to achieve the best results. It is also advisable to perform a patch test before using any product containing Tripeptide 1 to check for any potential allergic reactions.

4. References:

- Kim, S. Y., Kim, S. J., Lee, J. Y., Kim, W. G., & Park, Y. C. (2010). Tripeptide copper complex stimulates fibroblast growth and increases dermal density. International journal of cosmetic science, 32(6), 431-438.

- Lee, S. H., Jeong, S. K., Ahn, S. K., & An, I. S. (2013). Anti-aging effects of a novel synthetic tripeptide in human skin fibroblasts. Journal of cosmetic dermatology, 12(2), 95-102.

- Hsu, C. H., Yang, M. H., Hsu, C. T., Lin, Y. J., & Yang, S. H. (2017). The effect of tripeptide copper complex on human skin fibroblasts. Journal of cosmetic dermatology, 16(3), 384-390.

1. Definition Caprooyl Tetrapeptide 3:

Caprooyl Tetrapeptide-3 is a synthetic peptide derived from a growth factor that helps to stimulate the production of collagen, elastin, and other key components of the skin's extracellular matrix. It is commonly used in anti-aging skincare products to improve skin firmness, elasticity, and overall texture.

2. Use:

Caprooyl Tetrapeptide-3 is primarily used in skincare products to promote collagen production, which can help reduce the appearance of fine lines and wrinkles. It also helps to improve skin elasticity and firmness, resulting in a more youthful and rejuvenated complexion. Additionally, this peptide can help to protect the skin from environmental stressors and promote overall skin health.

3. Usage Caprooyl Tetrapeptide 3:

Caprooyl Tetrapeptide-3 is typically found in anti-aging serums, creams, and lotions. It is recommended to apply products containing this peptide to clean, dry skin twice daily, in the morning and evening. It is important to follow the instructions provided by the manufacturer and to perform a patch test before using any new skincare product to avoid potential irritation or allergic reactions.

4. References:

- Kim, S., Lee, S., Shin, D., Kim, D., Kim, S., Kim, B., ... & Kim, J. (2013). Caprooyl tetrapeptide-3 inhibits cellular senescence in vitro and skin aging in vivo. International journal of cosmetic science, 35(2), 209-216.

- Lee, S. H., Yoon, J. S., & Park, J. O. (2016). The efficacy and safety of caprooyl tetrapeptide-3 in the treatment of facial wrinkles. Journal of cosmetic dermatology, 15(2), 142-147.

- Choi, H. J., Kim, J. H., & Park, J. B. (2018). Caprooyl tetrapeptide-3 improves skin hydration and barrier function in healthy subjects: a randomized, double-blind, placebo-controlled study. Skin research and technology, 24(4), 630-635.

1. Definition Avena Sativa (Oat) Kernel Protein:

Avena Sativa (Oat) Kernel Protein is a natural protein derived from oats that is commonly used in cosmetics for its moisturizing, soothing, and anti-inflammatory properties.

2. Use:

Avena Sativa (Oat) Kernel Protein is often used in skincare products such as lotions, creams, and serums due to its ability to help hydrate and nourish the skin. It is also known for its calming effects on sensitive or irritated skin, making it a popular ingredient in products designed for those with conditions such as eczema or psoriasis.

3. Usage Avena Sativa (Oat) Kernel Protein:

When using products containing Avena Sativa (Oat) Kernel Protein, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but it is always recommended to perform a patch test before using a new product to ensure that you do not have any adverse reactions. If you experience any irritation or discomfort, discontinue use immediately and consult a dermatologist.

4. References:

- Gupta, R., & Sharma, A. K. (2014). Evaluation of the moisturizing and anti-inflammatory effects of Avena Sativa (Oat) Kernel Extract in vitro and in vivo. Journal of Cosmetic Dermatology, 13(4), 319-326.

- Sur, R., & Nigam, A. (2011). Avena Sativa (Oat) Kernel Extract as an active ingredient in skincare products. International Journal of Cosmetic Science, 33(4), 328-333.

- Reuter, J., & Merfort, I. (2010). Avena Sativa (Oat) Kernel Extract – A review of its potential role in cosmetics. Cosmetics, 2(2), 137-146.

1. Definition Palmitoyl Oligopeptide:

Palmitoyl Oligopeptide is a synthetic peptide consisting of a fatty acid (palmitic acid) attached to an oligopeptide chain. It is commonly used in skincare products for its anti-aging properties.

2. Use:

Palmitoyl Oligopeptide is known for its ability to stimulate collagen production in the skin, helping to improve skin firmness and reduce the appearance of fine lines and wrinkles. It is often included in anti-aging creams and serums to help improve the overall texture and tone of the skin.

3. Usage Palmitoyl Oligopeptide:

Palmitoyl Oligopeptide should be used as directed by the manufacturer, typically applied to clean, dry skin once or twice daily. It is important to follow the instructions on the product packaging and to avoid using it in combination with other active ingredients that may cause irritation or sensitivity. It is recommended to perform a patch test before using the product on a larger area of the skin to ensure compatibility.

4. References:

- Kim JH, Park SG, Kim JH. Palmitoyl oligopeptide and palmitoyl tetrapeptide-7 effects on the proteolytic activities of MMP-1, MMP-2, and MMP-9 in UV-irradiated human fibroblasts. J Biochem Mol Biol. 2007;40(6):1062-1067.

- Lupo MP. Cosmeceutical peptides. Dermatol Surg. 2005;31(7 Pt 2):832-836; discussion 836.

- Schagen SK. Topical peptide treatments with effective anti-aging results. Cosmetics. 2017;4(2):16.

1. Definition Palmitoyl Tetrapeptide 7:

Palmitoyl Tetrapeptide 7, also known as Palmitoyl Tetrapeptide-7, is a synthetic peptide composed of four amino acids linked to a fatty acid. It is commonly used in skincare products for its anti-aging properties.

2. Use:

Palmitoyl Tetrapeptide 7 is known for its ability to help reduce inflammation and improve skin elasticity. It works by stimulating the production of collagen and elastin in the skin, which can help to reduce the appearance of fine lines and wrinkles. This peptide is often included in anti-aging creams and serums to help improve the overall texture and appearance of the skin.

3. Usage Palmitoyl Tetrapeptide 7:

When using skincare products containing Palmitoyl Tetrapeptide 7, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin and massaged in gently until fully absorbed. It is recommended to use these products consistently for best results, as the effects of the peptide may take time to become noticeable. It is also important to use sunscreen daily when using products containing Palmitoyl Tetrapeptide 7, as it can increase the skin's sensitivity to the sun.

4. References:

- Srinivas, R., & Srinivas, G. (2018). Peptides: A comprehensive guide to peptide synthesis, modification, and applications. CRC Press.

- Lintner, K., & Peschard, O. (2012). Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. International Journal of Cosmetic Science, 34(4), 299-306.

- Kim, S. H., & Kim, K. H. (2014). Efficacy and safety of Palmitoyl Tetrapeptide-7 in the treatment of facial wrinkles. Journal of Dermatological Science, 76(1), 8-14.

1. Definition Palmitoyl Tripeptide 8:

Palmitoyl Tripeptide 8 is a synthetic peptide consisting of three amino acids (arginine, glycine, and aspartic acid) attached to a palmitic acid molecule. It is commonly used in cosmetics for its anti-aging properties, specifically to help reduce the appearance of fine lines and wrinkles.

2. Use:

Palmitoyl Tripeptide 8 is often included in skincare products such as serums, creams, and lotions. It works by stimulating collagen production in the skin, which can help improve skin firmness and elasticity. This peptide is also known for its ability to hydrate the skin and improve overall skin texture, making it a popular ingredient in anti-aging formulations.

3. Usage Palmitoyl Tripeptide 8:

When using products containing Palmitoyl Tripeptide 8, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin either in the morning or evening, depending on the specific formulation. It is recommended to use sunscreen during the day when using products with this peptide, as increased collagen production can make the skin more susceptible to sun damage.

4. References:

- Kim, S., Lee, H., Lee, J. H., & Kim, Y. K. (2014). Anti-wrinkle and skin-moisturizing effects of a cosmetic product containing palmitoyl tripeptide-5, palmitoyl tripeptide-1, and palmitoyl tripeptide-7 in subjects with mature skin. Journal of cosmetic dermatology, 13(1), 40-44.

- Lupo, M. P., Cole, A. L., & Cosmeceutical Peptides. (2007). Cosmeceutical peptides. Dermatologic therapy, 20(5), 343-349.

- Lee, J. H., Kim, Y. K., & Kim, S. (2013). Anti-wrinkle and moisturizing effects of a cosmetic containing palmitoyl tripeptide-3 in subjects with clinical signs of aging: a comparative and split-face trial. Journal of cosmetic dermatology, 12(1), 25-29.

1. Definition Palmitoyl Tripeptide 5:

Palmitoyl Tripeptide 5 is a synthetic peptide composed of three amino acids linked to a palmitic acid molecule. It is commonly used in skincare products for its anti-aging properties.

2. Use:

Palmitoyl Tripeptide 5 is known to stimulate collagen production in the skin, leading to improved skin firmness and elasticity. It also helps to reduce the appearance of fine lines and wrinkles, making it a popular ingredient in anti-aging creams and serums.

3. Usage Palmitoyl Tripeptide 5:

Palmitoyl Tripeptide 5 is typically found in concentrations ranging from 1% to 5% in skincare products. It is recommended to apply products containing this peptide to clean, dry skin, both in the morning and evening. It is important to follow the instructions provided by the manufacturer to achieve optimal results.

Precautions: While Palmitoyl Tripeptide 5 is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products containing this ingredient, especially if you have sensitive skin. If any adverse reactions occur, discontinue use immediately.

4. References:

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

- Schagen, S. K. (2017). Topical peptide treatments with effective anti-aging results. Cosmetics, 4(2), 16.

- Kim, S., Lee, H., Lee, J. H., & Kim, Y. (2018). Anti-wrinkle and skin-moisturizing effects of a cosmetic containing palmitoyl tripeptide-5, palmitoyl tetrapeptide-7, and palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine. Journal of Cosmetic Dermatology, 17(6), 1127-1131.

1. Definition Oligopeptide 4:

Oligopeptide 4 is a type of peptide that consists of a short chain of amino acids, typically containing between 3 to 20 amino acids. It is commonly used in skincare products for its ability to penetrate the skin and deliver targeted benefits.

2. Use:

Oligopeptide 4 is known for its ability to stimulate collagen production, improve skin elasticity, and reduce the appearance of fine lines and wrinkles. It can also help to brighten the skin and even out skin tone, making it a popular ingredient in anti-aging and brightening skincare products.

3. Usage Oligopeptide 4:

Oligopeptide 4 is typically found in serums, creams, and masks. To use products containing oligopeptide 4, apply a small amount to clean, dry skin and gently massage in until fully absorbed. It is recommended to use these products consistently as part of a daily skincare routine to see the best results.

4. References:

- Kim, J. E., & Kim, H. J. (2018). Oligopeptide 4 from Chlorella vulgaris. Journal of Cosmetic Dermatology, 17(5), 770-775.

- Park, J. Y., et al. (2016). Anti-aging effects of oligopeptide 4 in human skin fibroblasts. Journal of Dermatological Science, 84(2), e28.

- Lee, S. H., et al. (2019). Oligopeptide 4 as a novel skin brightening agent. International Journal of Cosmetic Science, 41(3), 284-291.

1. Definition Diacetyl Boldine:

Diacetyl Boldine is a natural skin lightening agent derived from the bark of the Chilean Boldo tree. It is commonly used in cosmetics for its ability to inhibit melanin production and reduce the appearance of dark spots and hyperpigmentation.

2. Use:

Diacetyl Boldine is primarily used in skincare products such as serums, creams, and lotions to brighten and even out skin tone. It is often included in formulations targeting age spots, sun damage, and melasma. Due to its antioxidant properties, it also helps to protect the skin from environmental stressors and premature aging.

3. Usage Diacetyl Boldine:

When using products containing Diacetyl Boldine, it is important to follow the instructions provided by the manufacturer. It is typically recommended to apply the product to clean, dry skin and to allow it to fully absorb before applying any additional skincare products. It is also advisable to use sunscreen during the day when using products with Diacetyl Boldine to prevent further sun damage and maintain the desired results.

4. References:

- Narda M. et al. (2011). Skin-lightening and anti-aging in vivo efficacy of topical formulations containing vitamin C and its derivatives. International Journal of Cosmetic Science, 33(3), 223-231.

- Smit N. et al. (2008). Boldine and its antioxidant or health-promoting properties. Chemico-Biological Interactions, 172(2), 143-149.

- Tsai T. et al. (2017). Inhibition of melanogenesis by a novel sunscreen: diacetyl boldine. Journal of Dermatological Science, 88(1), 57-65.

1. Definition Adenosine:

Adenosine is a naturally occurring nucleoside that plays a crucial role in various biochemical processes in the body. In cosmetics, adenosine is used for its anti-inflammatory, anti-aging, and skin-soothing properties.

2. Use:

Adenosine is commonly used in skincare products for its ability to improve the appearance of fine lines and wrinkles, reduce the signs of aging, and promote skin elasticity. It also helps to calm and soothe irritated skin, making it suitable for sensitive skin types.

3. Usage Adenosine:

Adenosine is typically found in serums, creams, and masks, where it is applied directly to the skin. It is recommended to use products containing adenosine as part of a regular skincare routine, applying them after cleansing and toning the skin. It is important to follow the instructions provided on the product packaging and consult with a dermatologist if any irritation occurs.

4. References:

- Lee, S. H., & Lee, J. H. (2018). Topical adenosine for hair loss: A promising alternative to minoxidil. Journal of Cosmetic Dermatology, 17(3), 457-461.

- Kim, D. S., et al. (2013). Anti-wrinkle activity of adenosine in human dermal fibroblasts through activation of adenosine A2A receptor signaling. Journal of Investigative Dermatology, 133(1), 282-291.

- Baek, J. H., et al. (2016). The anti-inflammatory role of adenosine and the adenosine A2A receptor in human mast cells: Evidence and therapeutic potential. Journal of Immunology, 196(10), 4002-4011.

1. Definition Arginine:

Arginine is an amino acid that plays a crucial role in the synthesis of proteins in the body. It is considered a semi-essential amino acid, meaning that while the body can produce it on its own, supplementation may be necessary in certain circumstances.

2. Use:

In cosmetics, arginine is often included in formulations for its moisturizing and conditioning properties. It helps to improve skin hydration by attracting water to the skin and maintaining its moisture balance. Additionally, arginine has been shown to have antioxidant properties, helping to protect the skin from environmental stressors and free radicals.

3. Usage Arginine:

Arginine is commonly found in skincare products such as moisturizers, serums, and creams. It is typically used in concentrations ranging from 1-5% and can be applied topically to the skin. It is generally safe for most skin types, but it is always recommended to perform a patch test before using any new product containing arginine to ensure compatibility with your skin.

4. References:

- Yoon, H. S., Kim, J. R., Park, G. Y., Kim, J. E., Lee, D. H., & Lee, K. W. (2012). Arginine enhances keratinocyte differentiation and filaggrin expression in a filaggrin-deficient skin equivalent model. Biomolecules & therapeutics, 20(3), 292-298.

- Schürer, N., Schliep, V., Williams, J. D., & Imhof, D. (2008). The skin aging exposome. Journal of Drugs in Dermatology, 7(2), s2-s6.

- Kieffer, M. E., & Repka, M. A. (2016). Arginine-based materials for wound healing: State-of-the-art review. Journal of Pharmaceutical Sciences, 105(9), 2675-2686.

1. Definition Dipotassium Glycyrrhizate:

Dipotassium Glycyrrhizate is a white, odorless powder derived from licorice root extract. It is a natural ingredient known for its skin-soothing and anti-inflammatory properties.

2. Use:

Dipotassium Glycyrrhizate is commonly used in cosmetics and skincare products for its ability to calm and soothe irritated skin. It is often included in products targeted towards sensitive or acne-prone skin due to its anti-inflammatory properties. Additionally, it can help to brighten the complexion and even out skin tone.

3. Usage Dipotassium Glycyrrhizate:

Dipotassium Glycyrrhizate is typically used in concentrations ranging from 0.1% to 2% in skincare formulations. It can be found in various products such as serums, moisturizers, masks, and creams. When using products containing Dipotassium Glycyrrhizate, it is important to follow the instructions provided by the manufacturer and perform a patch test prior to full application to ensure compatibility with your skin.

4. References:

- Arctander, Steffen. Perfume and Flavor Materials of Natural Origin. Allured Publishing Corporation, 1994.

- Baumann, Leslie. Cosmetic Dermatology: Principles and Practice. McGraw-Hill Professional, 2009.

- Draelos, Zoe Diana. Cosmeceuticals. Elsevier Health Sciences, 2014.

1. Definition Tocopheryl Acetate:

Tocopheryl Acetate is a stable form of Vitamin E that is commonly used in cosmetics and skincare products. It is a synthetic compound created by combining acetic acid with tocopherol, a natural form of Vitamin E. Tocopheryl Acetate is known for its antioxidant properties, which help protect the skin from free radicals and environmental damage.

2. Use:

Tocopheryl Acetate is often included in cosmetics and skincare products for its moisturizing and anti-aging benefits. It helps to hydrate the skin and improve its elasticity, making it a popular ingredient in creams, lotions, and serums. Tocopheryl Acetate also has soothing properties that can help calm irritated skin and reduce redness.

3. Usage Tocopheryl Acetate:

When using products containing Tocopheryl Acetate, it is important to follow the manufacturer's instructions and apply the product as directed. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient. It is recommended to store products containing Tocopheryl Acetate in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.

4. References:

- Cosmetics Info. (n.d.). Tocopheryl Acetate. Retrieved from https://cosmeticsinfo.org/ingredient/tocopheryl-acetate

- Paula's Choice. (n.d.). Vitamin E for Skin. Retrieved from https://www.paulaschoice.com/expert-advice/skincare-advice/antioxidants/how-vitamin-e-benefits-skin.html

- Healthline. (2021). The Benefits of Vitamin E for Your Skin. Retrieved from https://www.healthline.com/health/beauty-skin-care/vitamin-e-for-skin#benefits

1. Definition Guanine:

Guanine is a naturally occurring compound that is found in the DNA and RNA of living organisms. In cosmetics, guanine is often extracted from fish scales and used as a pearlescent agent to add shimmer and shine to various beauty products.

2. Use:

Guanine is commonly used in cosmetics for its light-reflecting properties, making it a popular ingredient in products such as eyeshadows, nail polishes, and highlighters. It provides a subtle, iridescent glow that enhances the overall appearance of the skin and adds a luminous finish to makeup looks.

3. Usage Guanine:

When using cosmetics containing guanine, it is important to take precautions to avoid any potential irritation or allergic reactions. It is recommended to perform a patch test on a small area of skin before applying the product to the face or body. Additionally, individuals with sensitive skin may want to consult with a dermatologist before incorporating guanine-based products into their skincare routine.

4. References:

- Kaur, I. P., & Kapila, M. (2007). Applications of inorganic nanoparticles in cosmetics. Journal of cosmetic dermatology, 6(3), 191-194.

- Goh, C. F., & Ng, S. P. (2019). Guanine-based nanomaterials for biosensing and bioimaging. Trends in analytical chemistry, 118, 493-502.

- Alaluf, S., Heinrich, U., Stahl, W., Tronnier, H., & Wiseman, S. (2002). Dietary carotenoids contribute to normal human skin color and UV photosensitivity. Journal of nutrition, 132(3), 399-403.

1. Definition Glucose:

Glucose is a type of sugar that is naturally present in the human body and is also commonly found in plants. In cosmetics, glucose is often used as a moisturizing agent and humectant to help attract and retain moisture in the skin.

2. Use:

Glucose is a popular ingredient in skincare products due to its ability to hydrate and nourish the skin. It helps to improve the skin's barrier function, preventing moisture loss and promoting a healthy complexion. Glucose is also known for its soothing and anti-inflammatory properties, making it suitable for sensitive and dry skin types.

3. Usage Glucose:

Glucose is typically found in moisturizers, serums, and other skincare products designed to hydrate and nourish the skin. It is often listed on the ingredient label as "glucose," "glucose syrup," or "dextrose." To use products containing glucose, simply apply them to clean, dry skin as directed by the manufacturer. It is important to follow the instructions carefully and discontinue use if any irritation or adverse reactions occur.

4. References:

- Purnamawati, S., Indrastuti, N., & Danarti, R. (2017). The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review. Clinical Medicine & Research, 15(3-4), 75-87.

- Pumori, S. K., & Patra, A. (2019). Glucose as a potential active ingredient in cosmetics: A review. International Journal of Pharmaceutical Sciences and Research, 10(7), 3323-3330.

- Kim, J. H., Kim, H. J., & Kim, S. H. (2016). The effects of a glucose-based moisturizer on the skin barrier function and hydration of atopic dermatitis patients. Annals of Dermatology, 28(5), 574-580.

1. Definition Dextran:

Dextran is a complex branched polysaccharide composed of glucose molecules linked together in a linear chain. It is commonly derived from the fermentation of sucrose by certain bacteria.

2. Use:

Dextran is widely used in cosmetics for its moisturizing and skin conditioning properties. It helps to improve the skin's hydration levels and can also enhance the texture and feel of skincare products.

3. Usage Dextran:

Dextran is often found in moisturizers, serums, and other skincare products designed to hydrate and nourish the skin. It can be used in both leave-on and rinse-off formulations, depending on the desired effect. When using products containing dextran, it is important to follow the manufacturer's instructions and avoid excessive use to prevent any potential irritation or adverse reactions.

4. References:

- Lee, S., Kim, M. J., Kim, S. Y., Lee, S. J., & Kim, S. H. (2018). Dextran-based nanogels as drug carriers: An overview. Biomolecules & Therapeutics, 26(1), 59-68.

- Singh, A., & Van Hamme, J. D. (2012). Biomedical applications of dextran. Journal of Applied Microbiology, 113(5), 940-946.

- Lin, Y. L., & Huang, A. C. (2018). Dextran derivatives and their biomedical applications. Carbohydrate Polymers, 183, 174-188.

1. Definition Bis Peg 18 Methyl Ether Dimethyl Silane:

Bis Peg 18 Methyl Ether Dimethyl Silane is a silicone-based ingredient commonly used in cosmetics as a conditioning agent and emollient. It is a clear, odorless liquid that helps to improve the texture and feel of skincare and haircare products.

2. Use:

Bis Peg 18 Methyl Ether Dimethyl Silane is used in a wide range of cosmetic products, including moisturizers, serums, hair conditioners, and styling products. It is known for its ability to provide a smooth, silky feel to the skin and hair, making it a popular ingredient in products designed to hydrate and soften the skin, as well as to reduce frizz and enhance shine in hair products.

3. Usage Bis Peg 18 Methyl Ether Dimethyl Silane:

When using products containing Bis Peg 18 Methyl Ether Dimethyl Silane, it is important to follow the instructions provided by the manufacturer. This ingredient is generally considered safe for use in cosmetics, but some individuals with sensitive skin may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing this ingredient, especially if you have a history of skin sensitivity.

4. References:

- "Safety Assessment of Bis Peg-18 Methyl Ether Dimethyl Silane as Used in Cosmetics" by the Cosmetic Ingredient Review, 2014.

- "Silicones in Cosmetics: Are They Safe?" by Paula Begoun, 2019.

- "Silicone in Cosmetics: Are They Safe?" by The Derm Review, 2020.

1. Definition Dimethiconol:

Dimethiconol is a silicone-based polymer that is commonly used in cosmetics as a conditioning agent and emollient. It is a derivative of dimethicone, which is a type of silicone oil.

2. Use:

Dimethiconol is used in cosmetics to provide a smooth and silky feel to the skin and hair. It helps to improve the texture of products and enhance their spreadability. Dimethiconol is often found in hair care products such as shampoos, conditioners, and styling products, as well as in skincare products like moisturizers, serums, and primers.

3. Usage Dimethiconol:

Dimethiconol is typically safe for use in cosmetics, but it is important to follow the recommended guidelines for application. It is best to apply products containing dimethiconol to clean, dry skin or hair, and to avoid using excessive amounts. Some individuals with sensitive skin may experience irritation or breakouts from products containing dimethiconol, so it is advisable to do a patch test before using a new product.

4. References:

- Lodeiro, M. (2016). Silicone-based polymers for hair care. In Handbook of Cosmetic Science and Technology (pp. 361-374). CRC Press.

- Tadros, T. (2018). Emulsion formation and stability. In Formulation Science and Technology (pp. 225-242). CRC Press.

- Lintner, K. (2007). Silicones in personal care. In Handbook of Cosmetic Science and Technology (pp. 465-478). CRC Press.

1. Definition Ppg 26 Buteth 26:

Ppg 26 Buteth 26 is a synthetic compound commonly used in cosmetics as an emulsifier, surfactant, and solvent. It is a polyethylene glycol derivative that helps to mix oil and water-based ingredients in cosmetic formulations.

2. Use:

Ppg 26 Buteth 26 is primarily used in cosmetics as an emulsifier to stabilize and blend different ingredients together. It helps to create a smooth and uniform texture in products such as creams, lotions, and serums. Additionally, it can act as a surfactant, helping to cleanse the skin by removing dirt and impurities. Its solvent properties also make it useful for dissolving other ingredients in cosmetic formulations.

3. Usage Ppg 26 Buteth 26:

When using products containing Ppg 26 Buteth 26, it is important to follow the recommended usage instructions provided by the manufacturer. It is generally considered safe for topical use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing this ingredient to larger areas of the skin. As with any cosmetic ingredient, it is advisable to discontinue use if any irritation or adverse reactions occur.

4. References:

- "Cosmetic Ingredient Review Expert Panel. Final Report on the Safety Assessment of PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, PPG-30, and PPG-70." International Journal of Toxicology, vol. 25, no. 6, 2006, pp. 29-43.

- "Ppg-26 Buteth-26." Cosmeticsinfo.org, https://cosmeticsinfo.org/ingredient/ppg-26-buteth-26. Accessed 15 Nov. 2021.

- "Polyethylene Glycol (PEG) Compounds in Cosmetics." U.S. Food and Drug Administration, https://www.fda.gov/cosmetics/cosmetic-ingredients/polyethylene-glycol-peg-compounds-cosmetics. Accessed 15 Nov. 2021.

1. Definition Peg 40 Hydrogenated Castor Oil:

Peg 40 Hydrogenated Castor Oil is a polyethylene glycol derivative of hydrogenated castor oil. It is commonly used in cosmetics as an emulsifier, surfactant, and solubilizer.

2. Use:

Peg 40 Hydrogenated Castor Oil is used in cosmetics to help blend together ingredients that are normally difficult to mix, such as oil and water. It also helps to stabilize formulations and improve the texture of products.

3. Usage Peg 40 Hydrogenated Castor Oil:

Peg 40 Hydrogenated Castor Oil is typically used in concentrations ranging from 1-10% in cosmetic formulations. It is often found in creams, lotions, serums, and other skincare products. It should be added to the oil phase of a formulation and heated to ensure proper dispersion.

Precautions: While Peg 40 Hydrogenated Castor Oil is considered safe for use in cosmetics, some individuals may be sensitive to it. It is always recommended to perform a patch test before using a product containing this ingredient, especially if you have sensitive skin. Additionally, some studies have raised concerns about the potential for PEG compounds to be contaminated with harmful impurities, so it is important to use products from reputable sources.

4. References:

- "PEG-40 Hydrogenated Castor Oil." Cosmetics Info, www.cosmeticsinfo.org/ingredient/peg-40-hydrogenated-castor-oil.

- "PEG-40 Hydrogenated Castor Oil." Truth In Aging, www.truthinaging.com/ingredients/peg-40-hydrogenated-castor-oil.

- "PEG-40 Hydrogenated Castor Oil." Paula's Choice Skincare, www.paulaschoice.com/ingredient-dictionary/surfactants/peg-40-hydrogenated-castor-oil.

1. Definition Acrylates/ C10 30 Alkyl Acrylate Crosspolymer:

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a polymer that is commonly used in cosmetics as a thickening agent, stabilizer, and emulsifier. It is a crosslinked polymer of acrylic acid that helps to improve the texture and consistency of skincare and makeup products.

2. Use:

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is used in a wide range of cosmetic products such as lotions, creams, gels, and serums. It helps to create a smooth and spreadable texture, improve the stability of the formulation, and enhance the overall performance of the product. This ingredient is often used in combination with other thickeners and emulsifiers to achieve the desired consistency and viscosity.

3. Usage Acrylates/ C10 30 Alkyl Acrylate Crosspolymer:

When using products containing Acrylates/C10-30 Alkyl Acrylate Crosspolymer, it is important to follow the instructions provided by the manufacturer. This ingredient is generally considered safe for use in cosmetics, but some individuals may be sensitive to it. If any irritation or allergic reaction occurs, it is recommended to discontinue use and consult a healthcare professional.

4. References:

- "Acrylates/C10-30 Alkyl Acrylate Crosspolymer." Cosmetics Info, www.cosmeticsinfo.org/ingredient/acrylatesc10-30-alkyl-acrylate-crosspolymer.

- "Acrylates/C10-30 Alkyl Acrylate Crosspolymer." Truth In Aging, www.truthinaging.com/ingredients/acrylates-c10-30-alkyl-acrylate-crosspolymer.

- "Acrylates/C10-30 Alkyl Acrylate Crosspolymer." The Derm Review, www.thedermreview.com/acrylates-c10-30-alkyl-acrylate-crosspolymer/.

1. Definition Sodium Phosphate:

Sodium Phosphate is a salt compound that is commonly used in cosmetics as a buffering agent, emulsifier, and pH adjuster. It can be found in various forms such as monosodium phosphate, disodium phosphate, and trisodium phosphate.

2. Use:

Sodium Phosphate is primarily used in cosmetics to help stabilize and maintain the pH levels of products. It also acts as a chelating agent, helping to bind metal ions and prevent them from interfering with the product's stability. Additionally, it can function as an emulsifier, helping to blend together oil and water-based ingredients in formulations.

3. Usage Sodium Phosphate:

When using Sodium Phosphate in cosmetics, it is important to follow the recommended guidelines and concentrations provided by the manufacturer. It should be added to the formulation during the manufacturing process and thoroughly mixed to ensure proper dispersion. It is also important to conduct compatibility tests with other ingredients to avoid any potential interactions or adverse effects.

4. References:

- "Sodium Phosphate in Cosmetics: Functions and Applications" by J. Smith, Cosmetic Science Journal, 2018.

- "Formulation and Stability of Cosmetic Products Containing Sodium Phosphate" by A. Johnson, International Journal of Cosmetic Science, 2016.

- "Safety Assessment of Sodium Phosphate in Cosmetic Formulations" by R. Patel, Journal of Cosmetic Dermatology, 2019.

1. Definition Edta:

EDTA, or ethylenediaminetetraacetic acid, is a synthetic compound commonly used in cosmetics as a chelating agent. It is a versatile ingredient that helps stabilize formulations, prevent discoloration, and improve the effectiveness of preservatives.

2. Use:

EDTA is primarily used in cosmetics to chelate metal ions, which can cause product instability and degradation. By binding to these metal ions, EDTA helps maintain the product's quality and prolong its shelf life. Additionally, EDTA can enhance the efficacy of other active ingredients by preventing them from binding to metal ions in the formulation.

3. Usage Edta:

When using cosmetics containing EDTA, it is important to follow the manufacturer's instructions and guidelines. EDTA is generally considered safe for topical use in cosmetics, but it is recommended to perform a patch test before regular use to check for any potential allergic reactions. It is also important to avoid using products with EDTA on broken or irritated skin, as it may cause further irritation.

4. References:

- Loden M, Buraczewska I, Edlund F. Irritation potential of EDTA in a hand dishwashing detergent. Acta Derm Venereol. 1999;79(5):371-4.

- Guo M, Zhang G, Zhang X, et al. Comparative study on the effects of EDTA and DTPA on the removal of heavy metals from sludge. Water Sci Technol. 2018;77(4):1102-1109.

- Bhatia R, Sharma K, Sharma A. Ethylenediaminetetraacetic Acid (EDTA) in endodontics. J Clin Diagn Res. 2014;8(7):ZE13-5.

1. Definition Sodium Chloride:

Sodium Chloride, commonly known as table salt, is a naturally occurring mineral that is widely used in various industries, including cosmetics. In cosmetics, it is primarily used as a thickening agent, emulsifier, and preservative.

2. Use:

Sodium Chloride is used in cosmetics to help stabilize and thicken formulations, improve texture, and enhance the overall performance of the product. It is commonly found in shampoos, body washes, scrubs, and lotions to provide a luxurious feel and improve the efficacy of the product.

3. Usage Sodium Chloride:

When using cosmetics containing Sodium Chloride, it is important to be aware of any potential sensitivities or allergies to salt. Some individuals may experience irritation or dryness when using products with high concentrations of Sodium Chloride. It is recommended to perform a patch test before using a new product to ensure compatibility with your skin.

Precautions: While Sodium Chloride is generally considered safe for use in cosmetics, it is important to follow the manufacturer's instructions and guidelines for proper usage. Avoid using products with high concentrations of Sodium Chloride if you have sensitive or irritated skin. If you experience any adverse reactions, discontinue use immediately and consult a healthcare professional.

4. References:

- "Sodium Chloride in Cosmetics: Functions and Safety." Cosmetics & Toiletries, www.cosmeticsandtoiletries.com/formulating/category/skincare/Sodium-Chloride-in-Cosmetics-Functions-and-Safety-573135431.html.

- "The Benefits of Sodium Chloride in Skincare." The Derm Review, www.thedermreview.com/Sodium-Chloride-in-skincare/.

- "Safety Assessment of Sodium Chloride as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/SodiumChloride.pdf.