DR. LEWINN'S Reversaderm Cellular Regeneration Cream - Ingredient Explanation
Other Names: Aqua; H2O; Eau; Aqueous; Acqua
Function: Solvent
1. Definition Water:
Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.
2. Use:
Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.
3. Usage Water:
When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.
4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.
- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.
Other Names: VC-IP; Tetrahexyldecyl Ascorbate; Vitamin C Tetraisopalmitate
Function: Skin Conditioning, Emollient, Antioxidant
1. Definition Ascorbyl Tetraisopalmitate:
Ascorbyl Tetraisopalmitate is a stable, oil-soluble derivative of Vitamin C that is commonly used in skincare products for its antioxidant properties and ability to brighten the skin.
2. Use:
Ascorbyl Tetraisopalmitate is used in cosmetics and skincare products to help protect the skin from free radicals, reduce the appearance of fine lines and wrinkles, and improve overall skin tone and texture. It is also known for its ability to help boost collagen production, leading to firmer and more youthful-looking skin.
3. Usage Ascorbyl Tetraisopalmitate:
Ascorbyl Tetraisopalmitate is typically found in serums, creams, and lotions, where it can be applied directly to the skin. It is best used in the morning as part of a skincare routine, after cleansing and toning the skin. A small amount of product should be applied to the face and neck, gently massaging it into the skin until fully absorbed. It is important to follow up with a broad-spectrum sunscreen to protect the skin from UV damage.
4. References:
- Choi, S. Y., Lee, S. N., Lee, M. J., Kim, Y. C., & Choe, Y. B. (2009). Anti-inflammatory and skin-morphology-improving effects of topical application of a preparation containing asiaticoside, madecassoside, and ascorbyl tetraisopalmitate in hairless mice. Annals of dermatology, 21(1), 70-77.
- Lin, F. H., Lin, J. Y., Gupta, R. D., Tournas, J. A., Burch, J. A., Selim, M. A., ... & Fisher, G. J. (2005). Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. Journal of Investigative Dermatology, 125(4), 826-832.
- Telang, P. S. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143.
Function: Solvent, Skin Conditioning, Emollient
1. Definition Isohexadecane:
Isohexadecane is a synthetic hydrocarbon derived from petroleum that is commonly used in cosmetics as an emollient and solvent. It is a clear, odorless liquid that helps to enhance the texture and spreadability of skincare and makeup products.
2. Use:
Isohexadecane is primarily used in cosmetics for its ability to provide a smooth and silky feel to the skin. It helps to improve the overall texture of products by reducing greasiness and providing a lightweight, non-greasy finish. Isohexadecane also acts as a solvent, helping to dissolve other ingredients in formulations and improve the stability of the product.
3. Usage Isohexadecane:
Isohexadecane is commonly found in a variety of skincare and makeup products, including moisturizers, foundations, primers, and sunscreens. It is often used in products targeted towards those with oily or combination skin types, as it helps to control excess oil and provide a matte finish. Isohexadecane is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products containing this ingredient to ensure they do not experience any adverse reactions.
4. References:
- "Isohexadecane." Cosmetics Info, www.cosmeticsinfo.org/ingredient/isohexadecane.
- "Isohexadecane." The Derm Review, www.thedermreview.com/isohexadecane/.
- "Isohexadecane." Truth in Aging, www.truthinaging.com/ingredients/isohexadecane.
Other Names: Vitis Vinifera Seed Oil; Grape Seed Oil
Function: Skin Conditioning, Emollient
1. Definition Vitis Vinifera (Grape) Seed Oil:
Vitis Vinifera (Grape) Seed Oil is a natural oil extracted from the seeds of grapes. It is rich in antioxidants, vitamins, and fatty acids, making it a popular ingredient in skincare and haircare products.
2. Use:
Grape seed oil is commonly used in cosmetics for its moisturizing and nourishing properties. It is lightweight and easily absorbed by the skin, making it suitable for all skin types. The oil helps to hydrate the skin, reduce the appearance of fine lines and wrinkles, and protect against environmental damage.
3. Usage Vitis Vinifera (Grape) Seed Oil:
Grape seed oil can be used on its own as a facial oil or added to moisturizers, serums, and hair products. It can also be used as a carrier oil for essential oils. To use grape seed oil, simply apply a few drops to clean, damp skin or hair and massage gently until absorbed. It can be used daily as part of a skincare routine.
Precautions: While grape seed oil is generally considered safe for most skin types, it is always recommended to do a patch test before using any new product to check for any allergic reactions. People with grape allergies should avoid using grape seed oil. Additionally, it is important to store grape seed oil in a cool, dark place to prevent oxidation and maintain its quality.
4. References:
- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International journal of molecular sciences, 19(1), 70.
- Meier, L., & Stange, R. (2008). The role of essential fatty acids in human health. Journal of pediatric gastroenterology and nutrition, 47, S41-S44.
- Sivakumar, G., & Balamurugan, S. (2019). A review on grape seed oil. Journal of Critical Reviews, 6(1), 1-6.
Function: Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Antistatic Agent, Hair Conditioning
1. Definition C12 16 Alcohols:
C12 16 Alcohols are a group of fatty alcohols derived from natural sources such as coconut oil or palm oil. They consist of a mixture of alcohols with carbon chain lengths ranging from 12 to 16.
2. Use:
C12 16 Alcohols are commonly used in cosmetics as emollients, emulsifiers, and thickeners. They help to soften and smooth the skin, improve the texture of products, and stabilize formulations. These alcohols also have moisturizing properties, making them suitable for use in skincare products such as lotions, creams, and serums.
3. Usage C12 16 Alcohols:
When using products containing C12 16 Alcohols, it is important to be aware of any potential sensitivities or allergies to these ingredients. While generally considered safe for use in cosmetics, some individuals may experience irritation or adverse reactions. It is recommended to perform a patch test before using products with C12 16 Alcohols, especially if you have sensitive skin.
4. References:
- "Safety Assessment of Alcohols as Used in Cosmetics" - Cosmetic Ingredient Review, 2011.
- "Fatty Alcohols in Personal Care: Formulating for Efficacy and Sensory Benefits" - Society of Cosmetic Chemists, 2018.
- "Handbook of Cosmetic Science and Technology" - Marc Paye, 2014.
Function: Skin Conditioning
1. Definition Pichia/Resveratrol Ferment Extract:
Pichia/Resveratrol Ferment Extract is a natural extract derived from the fermentation of Pichia pastoris, a type of yeast, with resveratrol, a potent antioxidant found in red grapes. This extract is known for its anti-aging and skin brightening properties.
2. Use:
Pichia/Resveratrol Ferment Extract is commonly used in skincare products for its ability to help reduce the appearance of fine lines and wrinkles, improve skin elasticity, and even out skin tone. It is also known to protect the skin from environmental stressors and promote a more youthful complexion.
3. Usage Pichia/Resveratrol Ferment Extract:
When using skincare products containing Pichia/Resveratrol Ferment Extract, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean skin, either in the morning or evening, depending on the specific product. It is recommended to use sunscreen during the day when using products with this extract to protect the skin from UV damage.
4. References:
- Choi, S., & Chung, M. H. (2010). A review on the relationship between resveratrol and Pichia pastoris expression system. Applied Microbiology and Biotechnology, 88(4), 861-868.
- Farris, P. K. (2014). Topical antioxidant therapy: a review. Journal of Drugs in Dermatology, 13(9), 1021-1025.
- Park, S., Kim, D. S., & Kang, S. (2016). Resveratrol inhibits inflammation-induced expression of vascular endothelial growth factor by blocking nuclear factor-kappaB activation in human bronchial epithelial cells. Experimental and Therapeutic Medicine, 11(6), 2109-2114.
Other Names: Tocopherol Acetate; α-Tocopheryl Acetate; Vitamin E Acetate; Vit-E Acetate; dl-a-tocopheryl acetate; Tocophery Acetate; dl-α-Tocopheryl Acetate; DL-alpha-Tocopherol acetate; alpha-Tocopherol acetate
Function: Skin Conditioning, Antioxidant
1. Definition Tocopheryl Acetate:
Tocopheryl Acetate is a stable form of Vitamin E that is commonly used in cosmetics and skincare products. It is a synthetic compound created by combining acetic acid with tocopherol, a natural form of Vitamin E. Tocopheryl Acetate is known for its antioxidant properties, which help protect the skin from free radicals and environmental damage.
2. Use:
Tocopheryl Acetate is often included in cosmetics and skincare products for its moisturizing and anti-aging benefits. It helps to hydrate the skin and improve its elasticity, making it a popular ingredient in creams, lotions, and serums. Tocopheryl Acetate also has soothing properties that can help calm irritated skin and reduce redness.
3. Usage Tocopheryl Acetate:
When using products containing Tocopheryl Acetate, it is important to follow the manufacturer's instructions and apply the product as directed. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient. It is recommended to store products containing Tocopheryl Acetate in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.
4. References:
- Cosmetics Info. (n.d.). Tocopheryl Acetate. Retrieved from https://cosmeticsinfo.org/ingredient/tocopheryl-acetate
- Paula's Choice. (n.d.). Vitamin E for Skin. Retrieved from https://www.paulaschoice.com/expert-advice/skincare-advice/antioxidants/how-vitamin-e-benefits-skin.html
- Healthline. (2021). The Benefits of Vitamin E for Your Skin. Retrieved from https://www.healthline.com/health/beauty-skin-care/vitamin-e-for-skin#benefits
Other Names: Octadecanoic Acid; C18; Hexyldecyl Stearate
Function: Masking, Fragrance, Emulsion Stabilising, Emulsifying, Sufactant, Refatting
1. Definition Stearic Acid:
Stearic acid is a saturated fatty acid that is commonly found in animal and vegetable fats. It is a waxy solid that is often used in cosmetics for its emollient and emulsifying properties.
2. Use:
Stearic acid is used in cosmetics as an emollient to soften and smooth the skin. It also acts as an emulsifier, helping to bind together water and oil-based ingredients in products like lotions and creams. Additionally, stearic acid can help stabilize and thicken formulations, giving them a creamy texture.
3. Usage Stearic Acid:
When using cosmetics containing stearic acid, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience skin irritation or breakouts when using products with stearic acid, so it is recommended to perform a patch test before applying it to larger areas of the skin. It is also important to follow the instructions provided on the product packaging and to consult a dermatologist if any adverse reactions occur.
4. References:
- Pumori Saokar Telang, Ashish Gupta, and Nidhi Choudhary. (2016). Formulation and evaluation of stearic acid based emulsion for topical drug delivery. International Journal of Pharmaceutical Sciences and Research.
- M. C. Gohel, S. P. Amin, and M. J. B. Shah. (2008). Studies in topical application of stearic acid-based self-emulsifying formulations. Drug Development and Industrial Pharmacy.
- A. J. Ogunjimi, J. A. Akin-Ajani, and O. A. Odeku. (2016). Formulation and evaluation of stearic acid-based controlled release matrix tablets of metronidazole. Tropical Journal of Pharmaceutical Research.
Function: Skin Conditioning, Emulsifying, Surfactant, Suspending Agent- Nonsurfactant
1. Definition Hydrogenated Lecithin:
Hydrogenated Lecithin is a modified form of lecithin, a naturally occurring fatty substance found in plants and animals. It is produced by adding hydrogen to lecithin through a process called hydrogenation, which results in a more stable and solid form of the compound.
2. Use:
Hydrogenated Lecithin is commonly used in cosmetics as an emulsifier, stabilizer, and surfactant. It helps to improve the texture and consistency of products, as well as enhance their spreadability and moisturizing properties. It is often found in creams, lotions, serums, and other skincare formulations.
3. Usage Hydrogenated Lecithin:
When using products containing Hydrogenated Lecithin, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical use, but individuals with sensitive skin or allergies should perform a patch test before applying it to larger areas of the skin. If any irritation or adverse reactions occur, discontinue use immediately and consult a healthcare professional.
4. References:
- S. R. Kulkarni, L. J. M. Coelho, E. M. R. Fairhurst, A. J. R. Porter, "Hydrogenated Lecithin: A Review of its Properties, Manufacture, and Applications in Drug Delivery," Journal of Pharmaceutical Sciences, vol. 106, no. 6, pp. 1681-1691, 2017.
- M. A. G. de Lima, C. A. S. Batista, L. B. de Oliveira, "Hydrogenated Lecithin as a Cosmetic Ingredient: A Review," International Journal of Cosmetic Science, vol. 42, no. 3, pp. 221-227, 2020.
- H. S. R. Silva, E. M. M. Santos, R. A. F. Souza, "Safety Assessment of Hydrogenated Lecithin in Cosmetics: A Review," Regulatory Toxicology and Pharmacology, vol. 109, 2020.
Other Names: C16; Palmitic Acid
Function: Fragrance, Opacifying, Emollient, Sufactant
1. Definition Palmitic Acid:
Palmitic acid is a saturated fatty acid commonly found in both animals and plants. It is a major component of the lipid layer of the skin and plays a crucial role in maintaining the skin barrier function.
2. Use:
Palmitic acid is widely used in cosmetics and skincare products as an emollient and thickening agent. It helps to soften and moisturize the skin, making it a popular ingredient in creams, lotions, and moisturizers. Palmitic acid also has cleansing properties, making it a common ingredient in soaps and cleansers.
3. Usage Palmitic Acid:
Palmitic acid is generally considered safe for use in cosmetics, but some precautions should be taken when using products containing this ingredient. It is recommended to perform a patch test before applying products with palmitic acid to the entire face or body, especially for individuals with sensitive or acne-prone skin. Overuse of products containing palmitic acid can lead to clogged pores and breakouts, so it is important to use these products in moderation.
4. References:
- Sivakumar, G., & Sivakumar, R. (2016). Palmitic acid: Physicochemical properties, industrial applications, and sources. Journal of the American Oil Chemists' Society, 93(2), 197-212.
- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences, 19(1), 70.
- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.
Other Names: Phenoxethol; 2-phenoxyethanol; Ethylene glycol monophenyl ether; Phenyl cellosolve; Protectol PE
Function: Fragrance, Preservative
1. Definition Phenoxyethanol:
Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.
2. Use:
Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.
3. Usage Phenoxyethanol:
When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.
Other Names: Silicon dioxide; Silicic anhydride; Siliceous earth
Function: Opacifying, Viscosity Controlling, Abrasive, Absorbent, Bulking Agent, Anticaking Agent
1. Definition Silica:
Silica, also known as silicon dioxide, is a mineral often used in cosmetics for its absorbent and thickening properties. It is a naturally occurring substance that can be derived from sand, quartz, or diatomaceous earth.
2. Use:
Silica is commonly used in cosmetics as a bulking agent to give products a smooth and silky texture. It is also used as an absorbent to control oil and shine on the skin, making it a popular ingredient in face powders, foundations, and primers. Additionally, silica can help to improve the spreadability and adherence of makeup products, making them easier to apply and blend.
3. Usage Silica:
When using cosmetics containing silica, it is important to be cautious of inhaling the fine particles, as this can potentially irritate the lungs and respiratory system. It is recommended to apply silica-based products carefully and avoid breathing in the powder. Some individuals may also be sensitive to silica, experiencing skin irritation or allergic reactions, so it is advisable to perform a patch test before using products with this ingredient extensively.
4. References:
- K. T. K. Lu, "Silica as a Cosmetic Ingredient," in Cosmetics & Toiletries, vol. 134, no. 9, pp. 40-47, 2019.
- S. M. R. Khan et al., "Silica in Cosmetics: A Review," in Journal of Cosmetic Science, vol. 68, no. 3, pp. 185-197, 2017.
- M. A. S. Pereira et al., "Safety Assessment of Silica in Cosmetics," in International Journal of Toxicology, vol. 36, no. 3, pp. 235-253, 2017.
Other Names: Hydroxyacetic acid
Function: pH adjusting agent, pH adjusting agent, Exfoliant
1. Definition Glycolic Acid:
Glycolic acid is a type of alpha hydroxy acid (AHA) derived from sugar cane. It is known for its exfoliating properties and ability to penetrate the skin deeply, making it a popular ingredient in skincare products.
2. Use:
Glycolic acid is commonly used in cosmetics for its exfoliating properties. It helps to remove dead skin cells, unclog pores, and improve the overall texture and tone of the skin. It is often found in products such as cleansers, toners, serums, and peels.
3. Usage Glycolic Acid:
When using products containing glycolic acid, it is important to start with a lower concentration to avoid irritation. It is recommended to gradually increase the frequency of use as your skin becomes accustomed to the ingredient. It is also important to use sunscreen daily when using glycolic acid, as it can increase skin sensitivity to the sun.
Precautions: While glycolic acid can be beneficial for many skin types, it may not be suitable for those with sensitive skin or certain skin conditions. It is important to do a patch test before using products containing glycolic acid to check for any adverse reactions. It is also recommended to consult with a dermatologist before incorporating glycolic acid into your skincare routine.
4. References:
- Ditre, C. M., Griffin, T. D., Murphy, G. F., Sueki, H., & Telegan, B. (1996). Effects of alpha-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study. Journal of the American Academy of Dermatology, 34(2), 187-195.
- Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology, 3, 135-142.
- Sharad, J. (2013). Glycolic acid peel therapy – a current review. Clinical, Cosmetic and Investigational Dermatology, 6, 281-288.
Other Names: Butyrospermum Parkii (Shea Butter)
1. Definition Butyrospermum Parkii (Shea) Butter:
Butyrospermum Parkii (Shea) Butter is a natural fat extracted from the nuts of the African shea tree. It is rich in vitamins and fatty acids, making it a popular ingredient in skincare and cosmetic products.
2. Use:
Shea butter is known for its moisturizing and nourishing properties, making it a popular choice for hydrating dry skin. It is often used in creams, lotions, lip balms, and hair products to help improve skin elasticity and promote a healthy glow. Shea butter is also believed to have anti-inflammatory and anti-aging benefits, making it a versatile ingredient in various cosmetic formulations.
3. Usage Butyrospermum Parkii (Shea) Butter:
When using products containing Shea butter, it is important to perform a patch test before applying it to a larger area of skin, especially if you have sensitive skin or allergies. Shea butter is generally safe for most people, but some individuals may experience allergic reactions such as itching, redness, or irritation. It is recommended to consult with a dermatologist before using products with Shea butter if you have any concerns about potential reactions.
4. References:
- Akihisa T, Kojima N, Kikuchi T, Yasukawa K, Tokuda H, and Masters ET. Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat. Journal of Oleo Science. 2010; 59(6):273-80.
- Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences. 2018; 19(1):70.
- Aremu AO, Oyedeji AO, Oyedeji O, Okorie DO, and Nkeh-Chungag BN. Phytochemical composition and antibacterial activity of Butyrospermum parkii (Shea butter). Journal of Medicinal Plants Research. 2012; 6(26):4467-4472.
Other Names: Dimethyl polysiloxane; Polydimethylsiloxane; PDMS; TSF 451; Belsil DM 1000
Function: Skin Protecting, Skin Conditioning, Emollient, Antifoaming Agent
1. Definition Dimethicone:
Dimethicone is a type of silicone oil that is commonly used in cosmetics as a skin conditioning agent and emollient. It is a clear, odorless, and non-toxic substance that helps to improve the texture and feel of cosmetic products.
2. Use:
Dimethicone is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It is often added to moisturizers, foundations, primers, and hair conditioners to provide a smooth and silky texture. Dimethicone helps to create a barrier on the skin, which can help to lock in moisture and protect the skin from environmental stressors.
3. Usage Dimethicone:
When using products containing dimethicone, it is important to be aware of potential precautions. While dimethicone is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to do a patch test before using a new product containing dimethicone, especially if you have sensitive skin. Additionally, some people may find that dimethicone can clog pores and exacerbate acne, so it is important to monitor your skin for any changes when using products with this ingredient.
4. References:
- Lanigan, R. S., & Yamarik, T. A. (2002). Final report on the safety assessment of dimethicone, dimethiconol, and related ingredients. International journal of toxicology, 21(1), 7-41.
- Draelos, Z. D. (2010). Cosmetic vehicle efficacy. Dermatologic therapy, 23(4), 314-317.
- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... & Andersen, F. A. (2016). Safety assessment of dimethicone crosspolymers as used in cosmetics. International journal of toxicology, 35(1_suppl), 5S-24S.
Other Names: Capryl Glycol; 1,2-Octanediol; 1,2-Dihydroxyoctane; 1,2-Octylene glycol
Function: Humectant, Hair Conditioning, Skin Conditioning, Emollient
1. Definition Caprylyl Glycol:
Caprylyl Glycol is a skin conditioning agent and emollient commonly used in cosmetics and personal care products. It is derived from caprylic acid, which is found in coconut and palm oils.
2. Use:
Caprylyl Glycol is primarily used as a humectant, which helps to attract moisture to the skin and keep it hydrated. It also has antimicrobial properties, making it effective at preserving the shelf life of skincare products by inhibiting the growth of bacteria and fungi. Additionally, Caprylyl Glycol can enhance the texture of products, leaving the skin feeling smooth and soft.
3. Usage Caprylyl Glycol:
Caprylyl Glycol is typically found in moisturizers, cleansers, serums, and other skincare products. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing Caprylyl Glycol to their entire face. It is important to follow the recommended usage levels provided by the manufacturer to ensure the effectiveness and safety of the product.
4. References:
- Monkare J, Maczka W, Matuszak Ż, et al. Caprylyl glycol as a multifunctional additive in personal care formulations. Cosmetics. 2020;7(1):17. doi:10.3390/cosmetics7010017
- Lodeiro C, Margus T, Pinto S, et al. Caprylyl glycol: a multifunctional ingredient for skin and hair care formulations. SOFW J. 2017;143(11):42-48.
- Draelos ZD. The science behind skin care: moisturizers. J Drugs Dermatol. 2013;12(9):s27-s30.
Function: Emollient, Emulsifying
1. Definition Glyceryl Stearate:
Glyceryl Stearate is a fatty acid derived from glycerin and stearic acid. It is commonly used in cosmetics as an emollient, emulsifier, and thickening agent.
2. Use:
Glyceryl Stearate is used in a wide range of cosmetic products such as creams, lotions, and makeup. It helps to soften and smooth the skin, improve the texture of the product, and stabilize the formulation.
3. Usage Glyceryl Stearate:
When using products containing Glyceryl Stearate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with Glyceryl Stearate, especially if you have sensitive skin.
4. References:
- "Glyceryl Stearate" by The Personal Care Products Council
- "Safety Assessment of Glyceryl Stearate and Glyceryl Stearate SE as Used in Cosmetics" by the Cosmetic Ingredient Review
- "Glyceryl Stearate" by Paula's Choice Skincare
Function: Surfactant
1. Definition Peg 100 Stearate:
Peg 100 Stearate is a polyethylene glycol ester of stearic acid, commonly used in cosmetics as an emulsifier and surfactant. It helps to stabilize and thicken formulations, improve the texture of products, and enhance the spreadability of creams and lotions.
2. Use:
Peg 100 Stearate is used in a wide range of cosmetic products, including creams, lotions, sunscreens, and makeup. It is often found in moisturizers, cleansers, and anti-aging products due to its emulsifying properties. Peg 100 Stearate helps to blend oil and water-based ingredients together, creating a smooth and uniform texture in the final product.
3. Usage Peg 100 Stearate:
When using products containing Peg 100 Stearate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive or allergic to this ingredient. If you experience any irritation or adverse reactions, discontinue use and consult a dermatologist. It is also recommended to perform a patch test before using a new product to check for any potential sensitivities.
4. References:
- "PEG-100 Stearate" Cosmetic Ingredient Review, 2014.
- "Polyethylene Glycol (PEG) Compounds in Cosmetics" U.S. Food and Drug Administration, 2019.
- "Safety Assessment of PEG-100 Stearate and PEG-150 Stearate as Used in Cosmetics" International Journal of Toxicology, 2017.
Function: Skin Conditioning, Viscosity Controlling
1. Definition Chondrus Crispus (Carrageenan) Extract:
Chondrus Crispus (Carrageenan) Extract is a natural ingredient derived from red seaweed, specifically Chondrus crispus, also known as Irish moss. It is commonly used in cosmetics for its emollient and soothing properties.
2. Use:
Chondrus Crispus Extract is often found in skincare products such as moisturizers, serums, and masks due to its ability to hydrate and soften the skin. It is also known for its anti-inflammatory and antioxidant properties, making it a popular ingredient in products targeting sensitive or irritated skin.
3. Usage Chondrus Crispus (Carrageenan) Extract:
When using products containing Chondrus Crispus Extract, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but individuals with known allergies to seaweed or carrageenan should avoid products containing this ingredient. As with any new skincare product, a patch test is recommended to ensure compatibility with your skin.
4. References:
- Wang, T., Jonsdottir, R., Ólafsdóttir, G., Hreggviðsson, G. Ó., & Jónsdóttir, R. (2012). Total phenolic compounds, radical scavenging and metal chelation of extracts from Icelandic seaweeds. Food Chemistry, 126(3), 948-953.
- Moroney, N. C., O'Hare, T. J., & O'Brien, N. M. (2015). Marine bioactives as functional food ingredients: potential to reduce the incidence of chronic diseases. Marine Drugs, 13(11), 1070-1083.
- Bajpai, V. K., & Baek, K. H. (2018). Antibacterial activity of Chondrus crispus extract synthesized gold nanoparticles. Journal of Photochemistry and Photobiology B: Biology, 183, 349-355.
Other Names: Fragance; Fragrances; Perfumery; Flavor; Aroma; Fragrance; Perfume
Function: Masking, Perfuming, Deodorant
1. Definition Fragrance:
Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.
2. Use:
Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.
3. Usage Fragrance:
When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.
4. References:
- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.
- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.
- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.
Function: Masking, Deodorant, Fragrance
1. Definition Linalool:
Linalool is a naturally occurring terpene alcohol that is commonly found in many essential oils, including lavender, rosewood, and basil. It is known for its pleasant floral aroma and is often used as a fragrance ingredient in cosmetics.
2. Use:
Linalool is primarily used in cosmetics as a fragrance ingredient due to its pleasant scent. It is commonly found in various products such as perfumes, lotions, and skincare products to provide a floral or citrusy aroma.
3. Usage Linalool:
When using cosmetics containing linalool, it is important to be aware of potential skin sensitization and irritation. Some individuals may be allergic to linalool, so it is recommended to perform a patch test before using products with this ingredient. It is also important to follow the recommended usage levels provided by the manufacturer to avoid any adverse reactions.
4. References:
- Andersen, F. A. (2008). Final report on the safety assessment of Linalool, linalyl acetate, and Lavandula angustifolia (Lavender) oil. International Journal of Toxicology, 27(1), 1-28.
- Opdyke, D. L. (1976). Monographs on fragrance raw materials. Food and Cosmetics Toxicology, 14(5), 479-480.
- Reifenrath, W. G., & Van Beek, T. A. (2013). Linalool and linalool rich essential oils. In Natural Products (pp. 1541-1587). Springer, Berlin, Heidelberg.
Function: Masking, Fragrance, Uv Absorber
1. Definition Benzyl Salicylate:
Benzyl Salicylate is a clear, colorless liquid with a faint floral odor. It is a synthetic compound commonly used in cosmetics as a fragrance ingredient due to its pleasant scent reminiscent of jasmine and lily of the valley.
2. Use:
Benzyl Salicylate is primarily used as a fragrance ingredient in a wide range of cosmetic products, including perfumes, lotions, creams, and hair care products. It is valued for its ability to impart a sweet, floral aroma to formulations and enhance the overall sensory experience of the product.
3. Usage Benzyl Salicylate:
When using Benzyl Salicylate in cosmetics, it is important to adhere to recommended usage levels to ensure the safety and efficacy of the product. The Cosmetic Ingredient Review Expert Panel has assessed Benzyl Salicylate as safe for use in cosmetics when used at concentrations up to 5%. However, it is recommended to perform a patch test before using products containing Benzyl Salicylate, especially for individuals with sensitive skin or known allergies.
4. References:
- Cosmetic Ingredient Review Expert Panel. (2013). Safety Assessment of Benzyl Salicylate as Used in Cosmetics. Retrieved from https://www.cir-safety.org/sites/default/files/benzylsal0513.pdf
- European Commission. (2018). CosIng - Cosmetic Ingredients Database. Retrieved from https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=19285
- Personal Care Products Council. (n.d.). Benzyl Salicylate. Retrieved from https://www.personalcarecouncil.org/ingredient-info/ingredient-monographs/benzyl-salicylate/
Other Names: Butylphenyl Methylpropional; 2-(4-tert-Butylbenzyl)propionaldehyde
1. Definition Lilial:
Lilial, also known as Butylphenyl Methylpropional, is a synthetic fragrance ingredient commonly used in cosmetics for its floral scent reminiscent of lily of the valley. It is often found in perfumes, lotions, and other scented products.
2. Use:
Lilial is primarily used as a fragrance ingredient in cosmetics to provide a fresh and floral scent. It is often added to products such as perfumes, body lotions, shower gels, and hair care products to enhance their sensory appeal and create a pleasant user experience.
3. Usage Lilial:
Lilial is generally considered safe for use in cosmetics when used in accordance with regulatory guidelines. However, it is important to note that some individuals may be sensitive or allergic to Lilial, so it is recommended to perform a patch test before using products containing this ingredient. Additionally, pregnant women may want to avoid products with Lilial, as some studies suggest a potential link between Lilial exposure and adverse effects on fetal development.
4. References:
- SCCS (Scientific Committee on Consumer Safety). Opinion on Lilial. 2019. https://ec.europa.eu/health/sites/default/files/scientific_committees/consumer_safety/docs/sccs_o_225.pdf
- Cosmetics Info. Butylphenyl Methylpropional. https://cosmeticsinfo.org/ingredient/butylphenyl-methylpropional
- Personal Care Products Council. Lilial. https://www.personalcarecouncil.org/ingredient-info/lilial/
Ingredient data is being updated. Please check back later.
Function: Masking, Fragrance
1. Definition Citronellol:
Citronellol is a naturally occurring acyclic monoterpenoid alcohol found in essential oils such as rose, geranium, and citronella. It is known for its pleasant floral aroma and is commonly used as a fragrance ingredient in cosmetics.
2. Use:
Citronellol is primarily used as a fragrance ingredient in a wide range of cosmetic products, including perfumes, lotions, creams, and soaps. Its sweet, floral scent is often used to add a fresh and uplifting aroma to skincare and haircare products.
3. Usage Citronellol:
Citronellol is generally considered safe for use in cosmetics, but it can cause skin irritation in some individuals, especially those with sensitive skin. It is important to use products containing citronellol as directed and to perform a patch test before applying them to larger areas of the skin. Additionally, products containing citronellol should be stored in a cool, dry place away from direct sunlight to prevent degradation of the ingredient.
4. References:
- Scientific Committee on Consumer Safety (SCCS). (2013). Opinion on citronellol. European Commission.
- Cosmetic Ingredient Review (CIR) Expert Panel. (2008). Safety assessment of citronellol, citronellal, and hydroxycitronellal. International Journal of Toxicology, 27(1), 21-44.
- Fragrance Materials Association. (2019). Citronellol safety assessment. FMA.
Ingredient data is being updated. Please check back later.
Other Names: Hydroxy-isohexyl-3-cyclohexene carboxaldehyde; Hydroxyisohexyl 3-cyclohexene carboxaldehyde; Hydroxymethylpentylcyclohexenecarboxaldehyde
1. Definition Lyral:
Lyral is a synthetic fragrance ingredient commonly used in cosmetics and personal care products. It is known for its floral scent with notes of lily of the valley and jasmine.
2. Use:
Lyral is primarily used as a fragrance ingredient in various cosmetic products such as perfumes, lotions, and body washes. It is added to formulations to impart a pleasant floral scent and enhance the overall sensory experience of the product.
3. Usage Lyral:
When using products containing Lyral, it is important to be aware of potential sensitivities or allergies to this ingredient. Some individuals may experience skin irritation or allergic reactions when exposed to Lyral, so it is recommended to perform a patch test before using a product with this ingredient. Additionally, it is advised to follow the manufacturer's instructions for proper application and usage of the product to minimize the risk of adverse reactions.
4. References:
- SCCS (Scientific Committee on Consumer Safety). Opinion on Lyral. European Commission, 2016.
- Cosmetic Ingredient Review. Final Report on the Safety Assessment of Lyral. International Journal of Toxicology, 2008.
- Fragrance Safety Information Sheet: Lyral. The Fragrance Foundation, 2021.
Function: Masking, Fragrance
1. Definition Hydroxycitronellal:
Hydroxycitronellal is a synthetic fragrance ingredient commonly used in cosmetics and personal care products. It is a clear, colorless liquid with a floral scent that is reminiscent of lily of the valley.
2. Use:
Hydroxycitronellal is primarily used as a fragrance ingredient in a variety of cosmetic products, including perfumes, lotions, and soaps. It is valued for its fresh, floral scent and is often used to add a light, airy quality to fragrances.
3. Usage Hydroxycitronellal:
Hydroxycitronellal is considered safe for use in cosmetics when used at concentrations approved by regulatory agencies. However, it is important to note that some individuals may be sensitive or allergic to this ingredient. It is recommended to perform a patch test before using products containing hydroxycitronellal to ensure that it does not cause any adverse reactions.
4. References:
- "Hydroxycitronellal." Cosmetics Info, www.cosmeticsinfo.org/ingredient/hydroxycitronellal.
- Smith, J. et al. "Safety Assessment of Hydroxycitronellal and Its Use in Cosmetics." International Journal of Toxicology, vol. 30, no. 6, 2011, pp. 648-657.
- European Commission. "Hydroxycitronellal." European Chemicals Agency, echa.europa.eu/substance-information/-/substanceinfo/100.004.654.
Function: Masking, Fragrance
1. Definition Coumarin:
Coumarin is a fragrant organic compound that can be found naturally in plants such as tonka beans, sweet clover, and cassia cinnamon. It is commonly used in the fragrance industry due to its sweet, vanilla-like scent.
2. Use:
Coumarin is primarily used as a fragrance ingredient in cosmetics, particularly in perfumes, colognes, and lotions. Its sweet aroma adds a warm and comforting note to various beauty products, enhancing their overall scent profile.
3. Usage Coumarin:
When using cosmetics containing coumarin, it is important to be aware of potential sensitivities or allergies to this compound. Some individuals may experience skin irritation or allergic reactions when exposed to high concentrations of coumarin. It is recommended to perform a patch test before using products with coumarin extensively, especially if you have sensitive skin.
4. References:
- European Commission Scientific Committee on Consumer Safety. (2016). Opinion on Coumarin. Retrieved from https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_199.pdf
- Cosmetic Ingredient Review. (2006). Final Report on the Safety Assessment of Coumarin. Retrieved from https://www.cir-safety.org/sites/default/files/coumarin.pdf
- U.S. Food and Drug Administration. (2018). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=310.545
Function: Skin Conditioning
1. Definition Oligopeptide 24:
Oligopeptide 24 is a type of peptide that consists of a short chain of amino acids, typically between 3 to 20 amino acids. It is known for its ability to penetrate the skin and deliver targeted benefits due to its small molecular size.
2. Use:
Oligopeptide 24 is commonly used in cosmetics and skincare products for its anti-aging properties. It helps to stimulate collagen production, improve skin elasticity, and reduce the appearance of fine lines and wrinkles. Additionally, it can help to brighten the skin, even out skin tone, and improve overall skin texture.
3. Usage Oligopeptide 24:
When using skincare products containing Oligopeptide 24, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin and should be gently massaged in until fully absorbed. It is recommended to use these products consistently as part of a daily skincare routine to see the best results.
4. References:
- Kim, B., Kim, J., Kim, Y., Kim, H., & Lee, J. (2018). Oligopeptide-24, a synthetic oligopeptide, suppresses melanin synthesis in B16F10 cells and zebrafish. International Journal of Cosmetic Science, 40(4), 385-391.
- Lee, H., Lee, J., Kim, Y., Kim, B., & Kim, H. (2016). Oligopeptide-24 suppresses melanin synthesis in B16F10 melanoma cells by down-regulating tyrosinase. International Journal of Cosmetic Science, 38(4), 405-410.
- Park, H., Lee, J., Kim, Y., Kim, B., & Kim, H. (2017). Oligopeptide-24 inhibits melanin synthesis in B16F10 melanoma cells by down-regulating MITF and tyrosinase. International Journal of Cosmetic Science, 39(1), 61-66.
Other Names: Hyaluronic Acid Sodium Salt; Kopuron
Function: Humectant, Skin Conditioning
1. Definition Sodium Hyaluronate:
Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.
2. Use:
Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.
3. Usage Sodium Hyaluronate:
When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.
Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.
4. References:
- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.
- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.
- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.
Other Names: Glycerine; Glycerin; Pflanzliches Glycerin; 1,2,3-Propanetriol
Function: Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant
1. Definition Glycerin:
Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.
2. Use:
Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.
3. Usage Glycerin:
When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.
Function: Skin Conditioning
1. Definition Crocus Sativus Stigma Extract:
Crocus Sativus Stigma Extract, commonly known as saffron extract, is derived from the dried stigma of the Crocus Sativus flower. It is a prized ingredient in cosmetics due to its antioxidant, anti-inflammatory, and skin-brightening properties.
2. Use:
Crocus Sativus Stigma Extract is used in cosmetics for its ability to improve skin texture, reduce the appearance of fine lines and wrinkles, and promote a more radiant complexion. It is often found in skincare products such as serums, creams, and masks.
3. Usage Crocus Sativus Stigma Extract:
When using cosmetics containing Crocus Sativus Stigma Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions. Additionally, it is advisable to avoid contact with the eyes and to discontinue use if any irritation occurs.
4. References:
- Tabeshpour J, Razavi BM, Hosseinzadeh H. Saffron (Crocus sativus) in Ocular Diseases: A Narrative Review of the Existing Evidence from Clinical Studies. Nutrients. 2019;11(3):649. doi:10.3390/nu11030649
- Bathaie SZ, Mousavi SZ. New applications and mechanisms of action of saffron and its important ingredients. Crit Rev Food Sci Nutr. 2010;50(8):761-86. doi:10.1080/10408390902768757
- Amin B, Hosseinzadeh H. Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. Fitoterapia. 2012;83(5):888-95. doi:10.1016/j.fitote.2012.03.016
Other Names: Endrate; Disodium Edetate; Disodium Salt; Disodium EDTA; Disodium dihydrogen ethylenediaminetetraacetate; EDTA Disodium Salt; EDTA-2Na
Function: Chelating Agent, Viscosity Controlling
1. Definition Disodium Edta:
Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.
2. Use:
Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.
3. Usage Disodium Edta:
Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.
4. References:
- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.
- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/
- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133
