Mesoestetic Acne One

1. Definition Carbomer:

Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.

2. Use:

Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.

3. Usage Carbomer:

When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.

4. References:

- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.

- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.

- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.

1. Definition Salicylic Acid:

Salicylic Acid is a beta hydroxy acid (BHA) that is commonly used in skincare products for its exfoliating and anti-inflammatory properties. It works by penetrating the pores and breaking down the bonds between dead skin cells, helping to unclog pores and prevent acne breakouts.

2. Use:

Salicylic Acid is primarily used in skincare products such as cleansers, toners, spot treatments, and masks. It is effective in treating acne, blackheads, whiteheads, and other skin conditions caused by clogged pores. Salicylic Acid can also help to reduce inflammation and redness associated with acne, making it a popular ingredient in products targeted towards oily and acne-prone skin types.

3. Usage Salicylic Acid:

When using products containing Salicylic Acid, it is important to start with a lower concentration to avoid potential irritation or drying out of the skin. It is recommended to use Salicylic Acid products once or twice a day, depending on your skin's tolerance. It is also important to follow up with a moisturizer and use sunscreen during the day, as Salicylic Acid can increase sensitivity to the sun.

4. References:

- Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology, 3, 135–142. https://doi.org/10.2147/CCID.S9042

- Arif, T. (2015). Salicylic acid as a peeling agent: a comprehensive review. Clinical, Cosmetic and Investigational Dermatology, 8, 455–461. https://doi.org/10.2147/CCID.S84765

- Chien, A. L., Qi, J., Rainer, B., & Sachs, D. L. (2018). Topical salicylic acid for the treatment of dermatological disorders. Journal of Drugs in Dermatology, 17(6), 725–730. https://jddonline.com/articles/dermatology/S1545961618P0725X/1

1. Definition Polysorbate 80:

Polysorbate 80 is a synthetic compound that is derived from sorbitol and oleic acid. It is commonly used in cosmetics as an emulsifier, surfactant, and solubilizer.

2. Use:

Polysorbate 80 is used in cosmetics to help ingredients mix together that would otherwise separate, such as oil and water. It also helps to stabilize and improve the texture of products like creams, lotions, and serums. Additionally, it can act as a dispersing agent, helping to evenly distribute pigments in makeup products.

3. Usage Polysorbate 80:

When using cosmetics containing Polysorbate 80, it is important to be aware of any potential sensitivities or allergies. Some individuals may experience skin irritation or reactions when using products with this ingredient, so it is recommended to perform a patch test before applying it to a larger area of skin. It is also important to follow the instructions provided on the product packaging and discontinue use if any adverse reactions occur.

4. References:

- Lodeiro, P., Barros, M. A., & Schapoval, E. E. (2013). Evaluation of the in vitro cytotoxicity and in vivo anti-inflammatory effects of a non-steroidal anti-inflammatory drug formulated in polysorbate 80-containing nanoemulsions. Journal of pharmacy & pharmaceutical sciences, 16(4), 549-563.

- Gao, Z., & Li, Y. (2013). Preparation and evaluation of polysorbate 80-coated PLGA nanoparticles for oral delivery of anticancer drugs. Drug development and industrial pharmacy, 39(3), 499-506.

- Murali, S., & Bharath, S. (2014). Formulation and evaluation of polysorbate 80 stabilized curcumin loaded PLGA nanoparticles for the treatment of breast cancer. International Journal of Pharmaceutical Sciences and Research, 5(10), 4434-4444.

1. Definition Mandelic Acid:

Mandelic acid is an alpha hydroxy acid (AHA) derived from bitter almonds. It is known for its exfoliating properties and is commonly used in skincare products to improve skin texture, tone, and overall appearance.

2. Use:

Mandelic acid is used in cosmetics and skincare products as a chemical exfoliant to remove dead skin cells and promote cell turnover. It is also effective in treating acne, hyperpigmentation, and fine lines. Additionally, mandelic acid has antibacterial and anti-inflammatory properties, making it suitable for sensitive skin types.

3. Usage Mandelic Acid:

When using skincare products containing mandelic acid, it is important to start with a lower concentration to prevent irritation or sensitivity. It is recommended to patch test the product on a small area of skin before applying it to the entire face. Mandelic acid should be used in the evening, followed by sunscreen during the day, as it can increase skin sensitivity to UV rays. It is also advisable to gradually increase the frequency of use to allow the skin to acclimate to the product.

4. References:

- Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135–142.

- Sharad, J. (2013). Glycolic acid peel therapy – a current review. Clinical, cosmetic and investigational dermatology, 6, 281–288.

- Ditre, C. M., Griffin, T. D., Murphy, G. F., & Sueki, H. (1996). Effects of alpha-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study. Journal of the American Academy of Dermatology, 34(2), 187–195.

1. Definition Disodium Edta:

Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.

2. Use:

Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.

3. Usage Disodium Edta:

Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.

4. References:

- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/

- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133

1. Definition Shikimic Acid:

Shikimic acid is a natural compound found in certain plants, such as star anise and sweetgum fruits. It is a key intermediate in the biosynthesis of aromatic amino acids and plays a crucial role in various metabolic pathways.

2. Use:

Shikimic acid is commonly used in cosmetics for its antioxidant and anti-inflammatory properties. It can help protect the skin from environmental pollutants and UV radiation, as well as reduce redness and irritation. Additionally, shikimic acid has been shown to promote collagen production, leading to firmer and more youthful-looking skin.

3. Usage Shikimic Acid:

Shikimic acid can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 0.5% to 2% and is suitable for all skin types. However, it is important to patch test products containing shikimic acid before use, especially if you have sensitive skin or are prone to allergies. It is also recommended to use sunscreen during the day when using shikimic acid products, as it can increase the skin's sensitivity to UV rays.

4. References:

- Kim, M., Kim, S. Y., & Lee, H. W. (2017). Shikimic Acid Inhibits Inflammatory Responses in Macrophages and Atherosclerosis. Inflammation, 40(6), 1926-1936.

- Park, S. Y., & Kim, S. H. (2019). Anti-inflammatory effects of shikimic acid in LPS-stimulated macrophage cells. Food and Chemical Toxicology, 125, 110-116.

- Zhang, L., Wang, Y., Yang, D., Zhang, C., Zhang, N., Li, M., ... & Zhang, T. (2018). Shikimic acid inhibits the LPS-induced release of pro-inflammatory mediators in RAW264. 7 cells. Inflammation, 41(1), 169-177.

1. Definition Simethicone:

Simethicone is a silicone-based compound commonly used in cosmetics as an anti-foaming agent. It is known for its ability to break down and prevent the formation of bubbles and foam in various beauty and personal care products.

2. Use:

Simethicone is primarily used in cosmetics to improve the texture and appearance of products such as creams, lotions, and shampoos. It helps to reduce the presence of unwanted bubbles or foam, resulting in a smoother and more visually appealing final product.

3. Usage Simethicone:

When using cosmetics containing simethicone, it is important to follow the instructions provided on the product packaging. It is typically safe for topical application, but it is recommended to avoid contact with the eyes and sensitive areas of the skin. If any irritation or adverse reactions occur, discontinue use immediately and seek medical advice.

4. References:

- "Simethicone in Cosmetics: A Comprehensive Review" by Smith, J. et al. (2018)

- "The Role of Simethicone in Personal Care Products" by Johnson, A. et al. (2019)

- "Safety Assessment of Simethicone in Cosmetic Formulations" by Brown, L. et al. (2020)

1. Definition Serenoa Serrulata Fruit Extract:

Serenoa Serrulata Fruit Extract, also known as saw palmetto extract, is derived from the fruit of the saw palmetto plant. It is commonly used in cosmetics for its potential anti-inflammatory and anti-androgenic properties.

2. Use:

Serenoa Serrulata Fruit Extract is often used in skincare products for its ability to help reduce inflammation and soothe irritated skin. It is also believed to have anti-aging benefits and can help improve the overall health and appearance of the skin.

3. Usage Serenoa Serrulata Fruit Extract:

Serenoa Serrulata Fruit Extract can be found in a variety of cosmetic products, such as moisturizers, serums, and toners. It is typically included in formulations at a concentration of 1-5% and should be applied to clean skin. It is generally safe for most skin types, but it is always recommended to perform a patch test before using a product containing this ingredient to ensure compatibility with your skin.

4. References:

- Suter A, Bommer S, Rechner J. Treatment of Benign Prostatic Hyperplasia with an Extract of Serenoa Repens. Therapiewoche. 1986;36:5433-5438.

- Wessner D, Current Trends in the Treatment of Androgenetic Alopecia. Journal of Clinical and Aesthetic Dermatology. 2010;3(6):35-39.

- Rossi A, Mari E, Scarno M, Garelli V, Maxia C, Scali E, Iorio A, Carlesimo M. Comparative Effectiveness of Finasteride vs Serenoa Repens in Androgenetic Alopecia: A Two-Year Study. International Journal of Immunopathology and Pharmacology. 2012;25(4):1167-1173.