Theraskin Theracne Barra

1. Definition Vp/ Va Copolymer:

Vp/Va Copolymer is a copolymer of vinylpyrrolidone (VP) and vinyl acetate (VA) that is commonly used in cosmetics as a film-forming agent and binder. It is a versatile ingredient that helps improve the texture, consistency, and hold of various cosmetic products.

2. Use:

Vp/Va Copolymer is used in a wide range of cosmetics, including hair styling products (such as hairsprays, gels, and mousses), makeup (such as mascaras, eyeliners, and foundations), and skincare products (such as creams, lotions, and sunscreens). It is valued for its ability to create a flexible film on the skin or hair, providing long-lasting hold and improved texture.

3. Usage Vp/ Va Copolymer:

When using cosmetics containing Vp/Va Copolymer, it is important to follow the manufacturer's instructions and guidelines. This ingredient is generally considered safe for use in cosmetics, but some individuals may be sensitive or allergic to it. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, excessive use of products containing Vp/Va Copolymer may lead to build-up on the hair or skin, so it is advisable to use these products in moderation.

4. References:

- Lachman, L., Lieberman, H. A., & Kanig, J. L. (2013). The Theory and Practice of Industrial Pharmacy. Lippincott Williams & Wilkins.

- Winter, R. A. (2008). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Three Rivers Press.

- Draelos, Z. D. (2015). Cosmeceuticals: Procedures in Cosmetic Dermatology Series. Elsevier.

1. Definition Zinc Pca:

Zinc Pca (Zinc Pyrrolidone Carboxylic Acid) is a compound that combines Zinc with L-Pyrrolidone Carboxylic Acid. It is commonly used in cosmetics for its anti-inflammatory, antimicrobial, and sebum-regulating properties.

2. Use:

Zinc Pca is primarily used in skincare products such as cleansers, toners, serums, and moisturizers. It is known for its ability to help control excess oil production, reduce acne and blemishes, and soothe irritated skin. Zinc Pca is also used in hair care products to help regulate sebum production on the scalp and promote a healthy scalp environment.

3. Usage Zinc Pca:

When using products containing Zinc Pca, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but individuals with sensitive skin may want to do a patch test before applying it to their face or body. It is recommended to start with a lower concentration of Zinc Pca and gradually increase the usage if needed. Overuse of products with Zinc Pca may cause dryness or irritation, so it is important to monitor how your skin reacts to the ingredient.

4. References:

- Draelos ZD. Essential fatty acids in dermatology. J Drugs Dermatol. 2010;9(6): 669-673.

- Pazyar N, Yaghoobi R, Rafiee E, Mehrabian A, Feily A. Skin wound healing and phytomedicine: a review. Skin Pharmacol Physiol. 2014;27(6):303-310.

- Brandt S. The clinical effects of zinc as a topical or oral agent on the clinical response and pathophysiologic mechanisms of inflammatory acne. J Drugs Dermatol. 2013;12(5):542-545.

1. Definition Triclosan:

Triclosan is a synthetic antibacterial and antifungal agent that is commonly used in personal care products such as soaps, toothpaste, and deodorants. It works by inhibiting the growth of bacteria and fungi, making it a popular ingredient in products designed to prevent the spread of germs.

2. Use:

Triclosan is primarily used as a preservative in cosmetics and personal care products to prevent the growth of bacteria and fungi. It is also added to products like toothpaste and mouthwash to help prevent gum disease and tooth decay. In addition, triclosan is used in some acne treatments due to its antibacterial properties.

3. Usage Triclosan:

While triclosan has been widely used in personal care products for many years, there are some concerns about its safety and potential negative effects on human health and the environment. Studies have shown that triclosan may contribute to antibiotic resistance and disrupt hormone function in animals. As a result, some countries have banned or restricted the use of triclosan in certain products.

Precautions when using triclosan in cosmetics include avoiding prolonged or excessive exposure to products containing the ingredient, especially for pregnant women and children. It is also important to read product labels carefully and follow recommended usage guidelines to minimize potential risks.

4. References:

- Aiello, A. E., Larson, E. L., & Levy, S. B. (2007). Consumer antibacterial soaps: effective or just risky? Clinical Infectious Diseases, 45(S2), S137-S147.

- Weatherly, L. M., & Gosse, J. A. (2017). Triclosan exposure, transformation, and human health effects. Journal of Toxicology and Environmental Health, Part B, 20(8), 447-469.

- Yueh, M. F., Taniguchi, K., Chen, S., Evans, R. M., Hammock, B. D., & Karin, M. (2014). The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proceedings of the National Academy of Sciences, 111(48), 17200-17205.

1. Definition Melaleuca Alternifolia (Tea Tree) Leaf Oil:

Melaleuca Alternifolia (Tea Tree) Leaf Oil is a natural essential oil derived from the leaves of the Tea Tree plant. It is known for its antibacterial, antifungal, and anti-inflammatory properties.

2. Use:

Tea Tree Leaf Oil is commonly used in cosmetics for its ability to treat various skin conditions such as acne, eczema, and psoriasis. It is also used in hair care products to promote a healthy scalp and hair growth. Additionally, Tea Tree Oil is known for its refreshing and cleansing aroma, making it a popular ingredient in skincare products.

3. Usage Melaleuca Alternifolia (Tea Tree) Leaf Oil:

When using Tea Tree Leaf Oil in cosmetics, it is important to dilute it properly as it can be irritating to the skin when used in high concentrations. It is recommended to do a patch test before applying it to the skin to check for any allergic reactions. Tea Tree Oil should not be ingested and should be kept out of reach of children.

4. References:

- Carson, C. F., Hammer, K. A., & Riley, T. V. (2006). Melaleuca alternifolia (Tea Tree) oil: a review of antimicrobial and other medicinal properties. Clinical Microbiology Reviews, 19(1), 50-62.

- Hammer, K. A., Carson, C. F., & Riley, T. V. (2012). Antifungal activity of the components of Melaleuca alternifolia (tea tree) oil. Journal of Applied Microbiology, 95(4), 853-860.

- Pazyar, N., Yaghoobi, R., Bagherani, N., & Kazerouni, A. (2013). A review of applications of tea tree oil in dermatology. International Journal of Dermatology, 52(7), 784-790.

1. Definition Butylphenyl Methylpropional:

Butylphenyl Methylpropional, also known as Lilial, is a synthetic fragrance ingredient commonly used in cosmetics and personal care products. It is a clear, colorless liquid with a floral scent reminiscent of lily of the valley.

2. Use:

Butylphenyl Methylpropional is used as a fragrance ingredient in a wide range of cosmetic products, including perfumes, lotions, creams, and hair care products. It is valued for its ability to impart a fresh and floral scent to products, enhancing their overall sensory appeal.

3. Usage Butylphenyl Methylpropional:

When using products containing Butylphenyl Methylpropional, it is important to be aware of potential sensitivities or allergies to the ingredient. Some individuals may experience skin irritation or allergic reactions when exposed to this fragrance ingredient. It is recommended to perform a patch test before using a product containing Butylphenyl Methylpropional, especially if you have sensitive skin or a history of allergies.

4. References:

- Scientific Committee on Consumer Safety (SCCS). (2018). Opinion on Butylphenyl Methylpropional. Retrieved from https://ec.europa.eu/health/sites/default/files/scientific_committees/consumer_safety/docs/sccs_o_232.pdf

- Cosmetics Info. (n.d.). Butylphenyl Methylpropional. Retrieved from https://cosmeticsinfo.org/ingredient/butylphenyl-methylpropional

- Environmental Working Group (EWG). (n.d.). Butylphenyl Methylpropional. Retrieved from https://www.ewg.org/skindeep/ingredients/702319-BUTYLPHENYL_METHYLPROPIONAL/

1. Definition Coumarin:

Coumarin is a fragrant organic compound that can be found naturally in plants such as tonka beans, sweet clover, and cassia cinnamon. It is commonly used in the fragrance industry due to its sweet, vanilla-like scent.

2. Use:

Coumarin is primarily used as a fragrance ingredient in cosmetics, particularly in perfumes, colognes, and lotions. Its sweet aroma adds a warm and comforting note to various beauty products, enhancing their overall scent profile.

3. Usage Coumarin:

When using cosmetics containing coumarin, it is important to be aware of potential sensitivities or allergies to this compound. Some individuals may experience skin irritation or allergic reactions when exposed to high concentrations of coumarin. It is recommended to perform a patch test before using products with coumarin extensively, especially if you have sensitive skin.

4. References:

- European Commission Scientific Committee on Consumer Safety. (2016). Opinion on Coumarin. Retrieved from https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_199.pdf

- Cosmetic Ingredient Review. (2006). Final Report on the Safety Assessment of Coumarin. Retrieved from https://www.cir-safety.org/sites/default/files/coumarin.pdf

- U.S. Food and Drug Administration. (2018). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=310.545

1. Definition Geraniol:

Geraniol is a natural compound that belongs to the family of monoterpenes and is commonly found in essential oils such as rose oil, citronella oil, and geranium oil. It has a sweet, floral scent and is often used in the fragrance industry.

2. Use:

Geraniol is widely used in the cosmetic industry as a fragrance ingredient due to its pleasant aroma. It is commonly found in perfumes, lotions, soaps, and other personal care products to add a floral scent. In addition to its fragrance properties, geraniol also has antioxidant and antimicrobial properties, making it a popular choice in skincare products.

3. Usage Geraniol:

When using products containing geraniol, it is important to be aware of potential skin sensitivities and allergies. Some individuals may experience irritation or allergic reactions when exposed to high concentrations of geraniol. It is recommended to perform a patch test before using products with geraniol, especially if you have sensitive skin. Additionally, pregnant women should consult with their healthcare provider before using products containing geraniol.

4. References:

- Burdock, G. A. (2010). Safety assessment of Geraniol as a food ingredient. Food and Chemical Toxicology, 48(2), 29-34.

- Rastogi, S. C., & Heydorn, S. (2001). Fragrance allergens in commercial products. Contact Dermatitis, 45(5), 221-226.

- Menz, J., & Kistler, A. (2015). Fragrance allergens in cosmetics – a review. Journal of the German Society of Dermatology, 13(6), 625-632.

1. Definition D Limonene:

D Limonene is a natural compound found in the peel of citrus fruits such as lemons, oranges, and grapefruits. It is commonly used as a fragrance ingredient in cosmetics due to its citrusy scent.

2. Use:

D Limonene is primarily used in cosmetics as a fragrance ingredient to impart a fresh and invigorating citrus scent to products such as perfumes, lotions, and skincare products. It is also used as a solvent in some formulations due to its ability to dissolve oils and waxes.

3. Usage D Limonene:

When using products containing D Limonene, it is important to be aware of potential skin sensitization and irritation. Some individuals may be allergic to D Limonene and may experience reactions such as redness, itching, or swelling upon contact with the skin. It is recommended to perform a patch test before using products containing D Limonene to determine if any sensitivity exists.

Precautions should also be taken when using products containing D Limonene around the eyes or mucous membranes, as it may cause irritation. It is advisable to avoid direct contact with these areas and to wash hands thoroughly after use.

4. References:

- RIFM. (2013). Safety Assessment of Limonene. Retrieved from https://www.rifm.org/limonene

- Cosmetic Ingredient Review. (2008). Final Report on the Safety Assessment of Limonene. Retrieved from https://www.cir-safety.org/sites/default/files/limonene.pdf

- FDA. (2020). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.60

1. Definition Fragrance:

Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.

2. Use:

Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.

3. Usage Fragrance:

When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.

4. References:

- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.

- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.

- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.

1. Definition Sodium Palmate:

Sodium Palmate is a sodium salt derived from palm oil and is commonly used in the production of soap and cosmetics. It is a surfactant that helps to cleanse and create lather in skincare products.

2. Use:

Sodium Palmate is often used as a cleansing agent in soap bars, body washes, and facial cleansers. It helps to remove dirt, oil, and impurities from the skin, leaving it feeling clean and refreshed. Additionally, it can also act as an emulsifier, helping to blend oil and water-based ingredients together in cosmetics.

3. Usage Sodium Palmate:

When using products containing Sodium Palmate, it is important to follow the instructions provided on the packaging. Avoid getting the product in your eyes, as it may cause irritation. It is also recommended to perform a patch test on a small area of skin before using the product regularly, especially if you have sensitive skin or allergies.

4. References:

- "Sodium Palmate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/sodium-palmate.

- "Palm Oil and Palm Kernel Oil Derivatives." Personal Care Products Council, www.personalcarecouncil.org/ingredient-info/palm-oil-and-palm-kernel-oil-derivatives/.

- "Sodium Palmate." Truth in Aging, www.truthinaging.com/ingredients/sodium-palmate.

1. Definition Sodium Palm Kernelate:

Sodium Palm Kernelate is the sodium salt of the fatty acids derived from palm kernel oil. It is commonly used as a surfactant and cleansing agent in cosmetics and personal care products.

2. Use:

Sodium Palm Kernelate is primarily used in skincare products such as soaps, cleansers, and shampoos due to its ability to create foam and effectively remove dirt and oil from the skin and hair. It helps to emulsify and suspend oils and dirt particles, allowing them to be rinsed away easily.

3. Usage Sodium Palm Kernelate:

When using products containing Sodium Palm Kernelate, it is important to follow the manufacturer's instructions for proper application and rinsing. While generally considered safe for use in cosmetics, some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing Sodium Palm Kernelate, especially if you have sensitive skin.

4. References:

- "Safety Assessment of Palm Kernel Oil and Palm Kernelate-Derived Ingredients as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel (2016)

- "Palm oil and palm kernel oil extraction and refining in Malaysia" by Yew Ai Tan et al. (2018)

- "Formulation and Evaluation of Palm Kernel Oil Based Nanoemulsion for Topical Delivery of Acyclovir" by S. Verma et al. (2020)

1. Definition Sodium Stearate:

Sodium Stearate is a sodium salt of stearic acid, which is a fatty acid commonly found in animal and vegetable fats. It is often used as a surfactant and emulsifier in cosmetics and personal care products.

2. Use:

Sodium Stearate is used in cosmetics as a cleansing agent, emulsifier, and stabilizer. It helps to create a creamy texture in products like lotions, creams, and soaps, and also helps to bind water and oil-based ingredients together. Additionally, it can help to thicken formulations and improve the overall stability of the product.

3. Usage Sodium Stearate:

When using Sodium Stearate in cosmetics, it is important to follow the recommended guidelines and usage levels provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products containing Sodium Stearate, especially if you have sensitive skin.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2014). Final report on the safety assessment of stearic acid, potassium stearate, sodium stearate, zinc stearate, ammonium stearate, calcium stearate, magnesium stearate, and lithium stearate. International Journal of Toxicology, 33(1), 34S-45S.

- Personal Care Council. (2019). Sodium Stearate. Retrieved from https://www.personalcarecouncil.org/ingredient-info/ingredient-detail/sodium-stearate

- U.S. Food and Drug Administration. (2020). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.8254

1. Definition Sodium Chloride:

Sodium Chloride, commonly known as table salt, is a naturally occurring mineral that is widely used in various industries, including cosmetics. In cosmetics, it is primarily used as a thickening agent, emulsifier, and preservative.

2. Use:

Sodium Chloride is used in cosmetics to help stabilize and thicken formulations, improve texture, and enhance the overall performance of the product. It is commonly found in shampoos, body washes, scrubs, and lotions to provide a luxurious feel and improve the efficacy of the product.

3. Usage Sodium Chloride:

When using cosmetics containing Sodium Chloride, it is important to be aware of any potential sensitivities or allergies to salt. Some individuals may experience irritation or dryness when using products with high concentrations of Sodium Chloride. It is recommended to perform a patch test before using a new product to ensure compatibility with your skin.

Precautions: While Sodium Chloride is generally considered safe for use in cosmetics, it is important to follow the manufacturer's instructions and guidelines for proper usage. Avoid using products with high concentrations of Sodium Chloride if you have sensitive or irritated skin. If you experience any adverse reactions, discontinue use immediately and consult a healthcare professional.

4. References:

- "Sodium Chloride in Cosmetics: Functions and Safety." Cosmetics & Toiletries, www.cosmeticsandtoiletries.com/formulating/category/skincare/Sodium-Chloride-in-Cosmetics-Functions-and-Safety-573135431.html.

- "The Benefits of Sodium Chloride in Skincare." The Derm Review, www.thedermreview.com/Sodium-Chloride-in-skincare/.

- "Safety Assessment of Sodium Chloride as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/SodiumChloride.pdf.

1. Definition Glycerin:

Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.

2. Use:

Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.

3. Usage Glycerin:

When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.

1. Definition Sodium Hydroxide:

Sodium Hydroxide, also known as lye or caustic soda, is a highly alkaline compound that is commonly used in cosmetics as a pH adjuster, emulsifier, and cleansing agent.

2. Use:

Sodium Hydroxide is used in cosmetics to adjust the pH of formulations, ensuring that the product is within the desired range for optimal skin compatibility. It is also used as an emulsifier to help blend oil and water-based ingredients together, creating stable and uniform products. Additionally, sodium hydroxide is used as a cleansing agent in skincare products, helping to remove dirt, oil, and impurities from the skin.

3. Usage Sodium Hydroxide:

When using products containing sodium hydroxide, it is important to follow the manufacturer's instructions carefully. Avoid direct contact with the eyes, as it can cause irritation or burns. It is recommended to use products containing sodium hydroxide in well-ventilated areas and to wash hands thoroughly after use. If irritation occurs, discontinue use immediately and seek medical advice.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2013). Final report on the safety assessment of sodium hydroxide. International Journal of Toxicology, 32(1), 59S-80S.

- Personal Care Products Council. (2020). Sodium Hydroxide. Retrieved from https://www.personalcarecouncil.org/ingredient-info/sodium-hydroxide/

- National Center for Biotechnology Information. (2021). Sodium Hydroxide. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-hydroxide

1. Definition Disodium Distyrylbiphenyl Disulfonate:

Disodium Distyrylbiphenyl Disulfonate is a synthetic fluorescent dye commonly used in cosmetics to provide a brightening effect. It is also known as DDBS or Fluorescent Brightener 230.

2. Use:

Disodium Distyrylbiphenyl Disulfonate is used in cosmetics as a brightening agent to enhance the appearance of the skin. It is commonly found in products such as foundations, concealers, highlighters, and skincare products to create a luminous and radiant complexion.

3. Usage Disodium Distyrylbiphenyl Disulfonate:

When using products containing Disodium Distyrylbiphenyl Disulfonate, it is important to follow the manufacturer's instructions and guidelines. It is recommended to perform a patch test on a small area of skin before applying the product to the entire face to check for any potential allergic reactions. Additionally, it is advisable to avoid direct contact with the eyes and mucous membranes. If any irritation or discomfort occurs, discontinue use immediately and seek medical advice.

4. References:

- Choi, S., Kim, H. J., & Lee, B. M. (2017). Toxicological evaluation of Disodium Distyrylbiphenyl Disulfonate (DDBS) as a cosmetic ingredient. Regulatory Toxicology and Pharmacology, 84, 1-6.

- Sagar, M., Kaur, M., Minz, A. P., & Kumar, N. (2019). Disodium Distyrylbiphenyl Disulfonate: A review on its properties, applications, and safety considerations in cosmetics. Journal of Cosmetic Dermatology, 18(2), 422-428.

- Kim, S. J., & Kim, J. (2018). Brightening effect of Disodium Distyrylbiphenyl Disulfonate in cosmetic formulations. International Journal of Cosmetic Science, 40(3), 285-290.

1. Definition Etidronic Acid:

Etidronic acid, also known as etidronate, is a synthetic organic compound that belongs to the class of bisphosphonates. It is commonly used in cosmetics as a chelating agent to prevent metal ions from interfering with the stability and effectiveness of various formulations.

2. Use:

Etidronic acid is primarily used in cosmetics as a chelating agent to improve the stability and shelf life of products. It helps to prevent the degradation of active ingredients caused by metal ions present in water or other raw materials. Additionally, etidronic acid can also enhance the effectiveness of preservatives and antioxidants in cosmetic formulations.

3. Usage Etidronic Acid:

Etidronic acid is typically added to cosmetic products in small concentrations, usually ranging from 0.1% to 1%. It is often found in skincare products, hair care products, and other personal care items. When using products containing etidronic acid, it is important to follow the manufacturer's instructions and avoid direct contact with eyes and mucous membranes. It is recommended to perform a patch test before using products with etidronic acid, especially for individuals with sensitive skin.

4. References:

- Sharma, A., & Sharma, S. (2019). Role of Chelating Agents in Cosmetics. International Journal of Cosmetic Science, 41(4), 359-366.

- Lupo, M. P. (2001). Antioxidants and Vitamins in Cosmetics. Clinics in Dermatology, 19(4), 467-473.

- Sarangapani, M., & Vakkalanka, M. S. (2017). Formulation and Evaluation of Etidronic Acid Loaded Liposomes for Topical Application. International Journal of Pharmaceutical Sciences and Research, 8(11), 4821-4828.