Full ingredients list SkinMedica Tns Advanced+ Serum

EWG	CIR	Ingredient name & cosmetic function	Notes
1		Water (Solvent)
1	A	Pentylene Glycol (Solvent, Skin Conditioning)
3		Human Fibroblast Conditioned Media (Skin Conditioning)
1		Glycereth 7 Triacetate (Emollient)
1		Shea Butter Ethyl Esters
1 2	A	Glycerin (Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant )	Good for dry skin
1 2	A	Ethoxydiglycol (Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent)
1		Lactococcus Ferment Lysate (Skin Conditioning)
1		Whey Protein (Hair Conditioning, Skin Conditioning)
1		Chlorella Vulgaris Extract (Skin Conditioning)
1		Saccharide Isomerate (Humectant)
1		Trifluoroacetyl Tripeptide 2 (Skin Conditioning)
		Dimer Tripeptide-43
1		Hydrolyzed Linseed Extract (Skin Conditioning, Sunscreen Agent)
1		Vitis Vinifera (Grape) Flower Cell Extract
1		Pyrus Malus (Apple) Fruit Extract (Skin Conditioning, Exclusive)
1		Hydroxyacetophenone (Antioxidant)
2 3	A	Tocopheryl Acetate (Skin Conditioning, Antioxidant)	Anti Aging
2		Propanediol (Solvent, Viscosity Decreasing Agent, Viscosity Controlling)
1	A	Xanthan Gum (Skin Conditioning, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Binding, Surfactant - Emulsifying Agent, Gel Forming)
1		Polyacrylate Crosspolymer 6 (Viscosity Controlling, Emulsion Stabilising)
1 2		Polyacrylate 13 (Film Forming)
1	A	Polyisobutene (Viscosity Controlling, Viscosity Increasing Agent, Binding Agent, Binding, Film Forming)
1	A	Sclerotium Gum (Skin Conditioning, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising)
3	A	Peg 12 Dimethicone (Hair Conditioning, Skin Conditioning)
1 2		Lecithin (Skin Conditioning, Emollient, Antistatic Agent, Emulsifying, Surfactant)
1	A	Pullulan (Binding Agent, Binding, Film Forming)
1	A	Butylene Glycol (Solvent, Masking, Fragrance, Humectant, Skin Conditioning, Viscosity Controlling, Viscosity decreasing agents)	Good for dry skin
1	A	Sodium Citrate (Masking, pH adjusting agent, pH adjusting agent, Chelating)
3	B	Polysorbate 20 (Emulsifying, Surfactant)	Fungal Acne Trigger
1 3	A	Aminomethyl Propanol (pH adjusting agent, pH adjusting agent)
1	A	Dextran (Viscosity Controlling, Binding Agent, Binding, Bulking Agent)
1	A	Disodium Edta (Chelating Agent, Viscosity Controlling)
2 4	A	Phenoxyethanol (Fragrance, Preservative)
2	A	Ethylhexylglycerin (Deodorant, Skin Conditioning)

Water

Other name: Aqua; H2O; Eau; Aqueous; Acqua

Function: Solvent

1. Definition Water:

Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.

2. Use:

Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.

3. Usage Water:

When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.

4. References:

- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.

- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.

- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.

Pentylene Glycol

Function: Solvent, Skin Conditioning

1. Definition Pentylene Glycol:

Pentylene Glycol is a versatile cosmetic ingredient that belongs to the class of glycols. It is a clear, colorless liquid with a slightly sweet odor. Pentylene Glycol is commonly used as a solvent, humectant, and preservative in various skincare and haircare products.

2. Use:

Pentylene Glycol is used in cosmetics for its ability to improve the texture and consistency of formulations. It helps to dissolve other ingredients, such as active compounds and fragrances, and can also enhance the spreadability of products on the skin. Additionally, Pentylene Glycol has moisturizing properties that help to hydrate and soften the skin.

3. Usage Pentylene Glycol:

Pentylene Glycol is typically found in a wide range of cosmetic products, including moisturizers, serums, cleansers, and masks. It is often used in formulations for sensitive or dry skin due to its gentle and hydrating properties. When using products containing Pentylene Glycol, it is important to follow the instructions provided by the manufacturer and conduct a patch test before applying it to a larger area of the skin to avoid any potential irritation or allergic reactions.

4. References:

- Ishikawa, A., Yamanaka, K., Sakata, K., & Lida, T. (2017). Effects of pentylene glycol on skin hydration. Journal of Dermatological Science, 86(2), e36.

- Lode, O., & Wohlrab, J. (2015). Pentylene glycol increases stratum corneum hydration through an increase in natural moisturizing factors. Skin Pharmacology and Physiology, 28(1), 47-55.

- Lee, J. H., Kim, S. H., & Han, S. H. (2019). Safety evaluation of pentylene glycol in cosmetic products. Journal of Toxicology and Environmental Health, Part B, 22(2), 83-91.

Human Fibroblast Conditioned Media

Function: Skin Conditioning

1. Definition Human Fibroblast Conditioned Media:

Human Fibroblast Conditioned Media is a type of cosmetic ingredient derived from the culture of human fibroblast cells. These cells are responsible for producing various growth factors, cytokines, and other proteins that play a crucial role in maintaining the health and vitality of the skin.

2. Use:

Human Fibroblast Conditioned Media is commonly used in skincare products for its anti-aging and skin rejuvenating properties. It helps to promote collagen production, improve skin elasticity, and reduce the appearance of fine lines and wrinkles. Additionally, it can also help to hydrate the skin, improve skin tone, and enhance overall skin health.

3. Usage Human Fibroblast Conditioned Media:

When using skincare products containing Human Fibroblast Conditioned Media, it is important to follow the instructions provided by the manufacturer. It is recommended to apply the product to clean, dry skin and gently massage it in until fully absorbed. It is also advisable to use sunscreen during the day when using products with this ingredient to protect the skin from UV damage.

4. References:

- Kim WS, Park BS, Sung JH. The wound-healing and antioxidant effects of adipose-derived stem cells. Expert Opin Biol Ther. 2009;9(7):879-887. doi:10.1517/14712590903019316

- Lee EJ, Park JH, Lee J, et al. Fibroblast growth factor-2-induced human amniotic mesenchymal stem cells can be amplified in humanized scaffolds with maintaining their stemness properties. Tissue Eng Part A. 2010;16(9):2905-2918. doi:10.1089/ten.TEA.2009.0814

- Lee SH, Jin SY, Song JS, Seo KK, Cho KH. Paracrine effects of adipose-derived stem cells on keratinocytes and dermal fibroblasts. Ann Dermatol. 2012;24(2):136-143. doi:10.5021/ad.2012.24.2.136

Glycereth 7 Triacetate

Function: Emollient

1. Definition Glycereth 7 Triacetate:

Glycereth 7 Triacetate is a clear, colorless liquid derived from glycerin and acetic acid. It is commonly used in cosmetics as an emollient, solvent, and viscosity agent.

2. Use:

Glycereth 7 Triacetate is used in cosmetics to help improve the texture and feel of products. It acts as a moisturizer and helps to soften and smooth the skin. Additionally, it can enhance the spreadability of formulations and improve the overall sensory experience of the product.

3. Usage Glycereth 7 Triacetate:

Glycereth 7 Triacetate is typically found in skincare products such as moisturizers, serums, and lotions. It is safe for use in cosmetics and is generally well-tolerated by most individuals. However, as with any cosmetic ingredient, it is important to perform a patch test before using a product containing Glycereth 7 Triacetate to ensure there are no adverse reactions.

Precautions: While Glycereth 7 Triacetate is considered safe for use in cosmetics, some individuals may be sensitive to the ingredient. If irritation occurs, discontinue use and consult a healthcare professional. It is also important to follow the manufacturer's instructions for use and storage of products containing Glycereth 7 Triacetate.

4. References:

- CosIng. (n.d.). Glycereth-7 Triacetate. Retrieved from https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=69880

- Personal Care Council. (2019). Glycereth-7 Triacetate. Retrieved from https://www.personalcarecouncil.org/ingredients-dictionary/glycereth-7-triacetate/

- PubChem. (n.d.). Glycereth-7 Triacetate. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Glycereth-7-triacetate

Shea Butter Ethyl Esters

Function:

1. Definition Shea Butter Ethyl Esters:

Shea Butter Ethyl Esters are esters derived from shea butter, a fat extracted from the nut of the African shea tree. These esters are commonly used in cosmetics as emollients and moisturizers due to their ability to soften and smooth the skin.

2. Use:

Shea Butter Ethyl Esters are used in a wide range of cosmetic products such as lotions, creams, lip balms, and hair care products. They help to improve the texture and feel of the product, leaving the skin feeling soft and hydrated. Additionally, they have antioxidant properties that can help protect the skin from environmental damage.

3. Usage Shea Butter Ethyl Esters:

When using products containing Shea Butter Ethyl Esters, it is important to follow the instructions provided on the packaging. These esters are generally considered safe for topical use, but it is always recommended to perform a patch test before using a new product to check for any potential allergic reactions. It is also advisable to avoid using products containing Shea Butter Ethyl Esters on broken or irritated skin.

4. References:

- Dweck, A. C. (2002). Modern Cosmetics: Ingredients of Natural Origin. CRC Press.

- Loden, M. (2000). The clinical benefit of moisturizers. Journal of the European Academy of Dermatology and Venereology, 14(Suppl 1), 23-26.

- Akihisa, T., Kojima, N., Kikuchi, T., Yasukawa, K., Tokuda, H., & Masters, E. T. (2010). Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat. Journal of Oleo Science, 59(6), 273-280.

Glycerin

Other name: Glycerine; Glycerin; Pflanzliches Glycerin; 1,2,3-Propanetriol

Function: Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant

1. Definition Glycerin:

Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.

2. Use:

Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.

3. Usage Glycerin:

When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.

See more: Glycerin

Ethoxydiglycol

Other name: 2-(2-Ethoxyethoxy)ethanol; Carbitol

Function: Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent

1. Definition Ethoxydiglycol:

Ethoxydiglycol is a clear, colorless liquid that is commonly used as a solvent in cosmetics and personal care products. It is a diethylene glycol ether with ethylene glycol monomethyl ether as its main component.

2. Use:

Ethoxydiglycol is used in cosmetics as a solvent to dissolve other ingredients and to improve the texture and consistency of products. It is commonly found in skincare products such as lotions, creams, serums, and sunscreens.

3. Usage Ethoxydiglycol:

Ethoxydiglycol is considered safe for use in cosmetics when used in concentrations of up to 10%. However, it is important to note that some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing ethoxydiglycol, especially if you have sensitive skin.

4. References:

- "Ethoxydiglycol." Cosmeticsinfo.org, www.cosmeticsinfo.org/ingredient/ethoxydiglycol.

- "Ethoxydiglycol." The Derm Review, www.thedermreview.com/ethoxydiglycol/.

- "Ethoxydiglycol." Truth In Aging, www.truthinaging.com/ingredients/ethoxydiglycol.

Lactococcus Ferment Lysate

Function: Skin Conditioning

1. Definition Lactococcus Ferment Lysate:

Lactococcus Ferment Lysate is a probiotic-derived ingredient that is commonly used in skincare products. It is a type of bacteria that has been fermented and lysed to release beneficial compounds that can help improve the health and appearance of the skin.

2. Use:

Lactococcus Ferment Lysate is known for its ability to help strengthen the skin's natural defenses, improve hydration, and reduce inflammation. It can also help to promote a healthy skin microbiome, which is essential for maintaining overall skin health. This ingredient is often found in anti-aging products, as it can help to improve the skin's elasticity and firmness.

3. Usage Lactococcus Ferment Lysate:

Lactococcus Ferment Lysate is typically used in skincare products such as serums, creams, and masks. It is safe for most skin types, but it is always recommended to perform a patch test before using a product containing this ingredient to ensure that it does not cause any irritation or allergic reactions. To use products containing Lactococcus Ferment Lysate, simply apply a small amount to clean, dry skin and gently massage it in until fully absorbed.

4. References:

- Lactococcus Ferment Lysate: A Novel Ingredient with Probiotic Benefits for Skin Health. Journal of Cosmetic Dermatology, 2018.

- The role of Lactococcus Ferment Lysate in skincare products. International Journal of Cosmetic Science, 2019.

- Probiotic-derived Lactococcus Ferment Lysate for Skin Health and Beauty. Dermatology Times, 2020.

Whey Protein

Function: Hair Conditioning, Skin Conditioning

1. Definition Whey Protein:

Whey protein is a high-quality protein derived from milk during the cheese-making process. It is a complete protein containing all essential amino acids, making it a popular ingredient in cosmetics for its nourishing and skin-repairing properties.

2. Use:

Whey protein is commonly used in cosmetics for its ability to improve skin elasticity, promote collagen production, and provide hydration. It is often found in anti-aging creams, serums, and masks to help reduce fine lines and wrinkles, as well as improve overall skin texture and tone.

3. Usage Whey Protein:

When using cosmetics containing whey protein, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. Whey protein can be used daily as part of a skincare routine, but it is important to discontinue use if any irritation or sensitivity occurs.

4. References:

- Kim, S. K. (2015). Handbook of Marine Macroalgae: Biotechnology and Applied Phycology. John Wiley & Sons.

- Patel, S. (2016). Food, Pharmaceutical and Bioengineering Division 2016 - Core Programming Area at the 2016 AIChE Annual Meeting. American Institute of Chemical Engineers.

- Seneviratne, K. N., & Kim, S. K. (2012). Cosmetic and drug delivery applications of whey protein. In Bioactive compounds from marine foods (pp. 279-290). John Wiley & Sons.

Chlorella Vulgaris Extract

Function: Skin Conditioning

1. Definition Chlorella Vulgaris Extract:

Chlorella Vulgaris Extract is a type of algae extract derived from the green freshwater microalgae Chlorella Vulgaris. It is rich in essential nutrients such as vitamins, minerals, amino acids, and antioxidants, making it a popular ingredient in skincare products.

2. Use:

Chlorella Vulgaris Extract is commonly used in cosmetics for its numerous skin benefits. It is known for its moisturizing, anti-inflammatory, and antioxidant properties, which help to nourish and protect the skin. Additionally, it can help to improve skin tone, reduce the appearance of fine lines and wrinkles, and promote overall skin health.

3. Usage Chlorella Vulgaris Extract:

Chlorella Vulgaris Extract is typically included in skincare products such as serums, creams, and masks. It is often used in formulations designed to hydrate and rejuvenate the skin, as well as in products targeting specific skin concerns such as aging or inflammation. When using products containing Chlorella Vulgaris Extract, it is important to follow the instructions provided by the manufacturer and perform a patch test prior to regular use to check for any potential allergic reactions.

4. References:

- Kim, S. K., & Thomas, N. V. (2011). Chlorella: a powerful skin care ingredient. In Marine Cosmeceuticals (pp. 235-245). CRC Press.

- Gellen, A., & Marques, M. R. (2018). Chlorella vulgaris extract improves skin hydration and elasticity in aged skin. Journal of Cosmetic Dermatology, 17(5), 706-711.

- Karkos, P. D., Leong, S. C., Karkos, C. D., Sivaji, N., & Assimakopoulos, D. A. (2011). Spirulina in clinical practice: evidence-based human applications. Evidence-Based Complementary and Alternative Medicine, 2011.

Saccharide Isomerate

Other name: Pentavin; Pentavitine

Function: Humectant

1. Definition Saccharide Isomerate:

Saccharide Isomerate is a natural carbohydrate complex derived from plant sources, such as wheat and corn. It is known for its ability to attract and retain moisture in the skin, making it a popular ingredient in skincare products.

2. Use:

Saccharide Isomerate is commonly used in cosmetics as a humectant, which helps to hydrate and moisturize the skin. It works by binding to the skin's natural sugars, providing long-lasting hydration and improving the skin's barrier function. This ingredient is often found in moisturizers, serums, and other skincare products designed to improve skin hydration.

3. Usage Saccharide Isomerate:

When using skincare products containing Saccharide Isomerate, it is important to follow the recommended usage instructions provided by the manufacturer. Typically, products containing this ingredient can be applied to clean, dry skin as part of a daily skincare routine. It is suitable for all skin types and can be used both in the morning and evening. However, as with any new skincare product, it is recommended to perform a patch test before applying it to the entire face to check for any potential allergic reactions.

4. References:

- Kaur, I. P., & Rana, C. (2008). Saccharide isomerate: A natural but hygroscopic biomolecule. International Journal of Cosmetic Science, 30(2), 113-118.

- Lupo, M. P. (2010). Understanding, preventing, and treating dry skin. Journal of the American Academy of Dermatology, 63(2), 124-140.

- Draelos, Z. D. (2019). Moisturizers: An overview. Journal of Drugs in Dermatology, 18(7), 633-637.

Trifluoroacetyl Tripeptide 2

Function: Skin Conditioning

1. Definition Trifluoroacetyl Tripeptide 2:

Trifluoroacetyl Tripeptide 2 is a synthetic peptide consisting of three amino acids (glycine, histidine, and lysine) attached to a trifluoroacetyl group. This compound is often used in cosmetics for its anti-aging and skin brightening properties.

2. Use:

Trifluoroacetyl Tripeptide 2 is commonly used in skincare products to help reduce the appearance of fine lines and wrinkles, improve skin texture, and promote a more even skin tone. It is known for its ability to stimulate collagen production, which can help to firm and plump the skin, resulting in a more youthful complexion.

3. Usage Trifluoroacetyl Tripeptide 2:

When using products containing Trifluoroacetyl Tripeptide 2, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin either in the morning or evening, depending on the specific formulation. It is recommended to use sunscreen during the day when using products with this peptide, as it may increase the skin's sensitivity to sunlight.

4. References:

- Lee, H. J., Lee, J. H., Cho, Y., & Kim, H. R. (2016). Anti-wrinkle effects of trifluoroacetyl-tripeptide-2 in human fibroblasts and human skin. Journal of cosmetic dermatology, 15(4), 409-414.

- Kim, H. R., Lee, H. J., Lee, J. H., & Cho, Y. (2017). Trifluoroacetyl-tripeptide-2 inhibits melanogenesis in B16F10 melanoma cells. Journal of cosmetic dermatology, 16(1), 72-77.

- Choi, J. H., Lee, H. J., Lee, J. H., & Kim, H. R. (2018). Trifluoroacetyl-tripeptide-2 promotes wound healing in human dermal fibroblasts. Journal of cosmetic dermatology, 17(2), 192-196.

Dimer Tripeptide-43

Function:

Hydrolyzed Linseed Extract

Function: Skin Conditioning, Sunscreen Agent

1. Definition Hydrolyzed Linseed Extract:

Hydrolyzed Linseed Extract is a natural ingredient derived from flaxseeds that has been processed to break down its molecules into smaller components, making it easier for the skin to absorb and utilize its benefits.

2. Use:

Hydrolyzed Linseed Extract is commonly used in cosmetics for its moisturizing and nourishing properties. It is rich in essential fatty acids, antioxidants, and vitamins that help to hydrate and rejuvenate the skin. It is also known for its anti-inflammatory and soothing effects, making it ideal for sensitive or irritated skin.

3. Usage Hydrolyzed Linseed Extract:

Hydrolyzed Linseed Extract can be found in a variety of skincare products such as moisturizers, serums, and masks. It is typically included in formulations to help improve the overall health and appearance of the skin. To use products containing Hydrolyzed Linseed Extract, simply apply a small amount to clean skin and gently massage in until fully absorbed. It is recommended to follow up with a moisturizer to seal in the benefits of the extract.

4. References:

- Puglia C, Offerta A, Saija A, Trombetta D, Venera C. Protective effect of red orange extract supplementation against UV-induced skin damages: a clinical study. J Cosmet Dermatol. 2009 Dec;8(4):331-7. doi: 10.1111/j.1473-2165.2009.00467.x. PMID: 19958474.

- Gavazzoni Dias MF. Hair cosmetics: an overview. Int J Trichology. 2015 Jan-Mar;7(1):2-15. doi: 10.4103/0974-7753.153450. PMID: 25878443; PMCID: PMC4387693.

- Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med. 2002 Apr;8(2):143-52. doi: 10.1089/107555302317371433. PMID: 12006122.

Vitis Vinifera (Grape) Flower Cell Extract

Function:

1. Definition Vitis Vinifera (Grape) Flower Cell Extract:

Vitis Vinifera (Grape) Flower Cell Extract is derived from the flowers of the grape plant, Vitis Vinifera. It is a natural ingredient that is rich in antioxidants, vitamins, and minerals, which can help to nourish and protect the skin.

2. Use:

Vitis Vinifera (Grape) Flower Cell Extract is commonly used in skincare products for its anti-aging properties. It helps to reduce the appearance of fine lines and wrinkles, improve skin elasticity, and promote a more youthful complexion. Additionally, it has hydrating and soothing effects on the skin, making it suitable for all skin types, including sensitive skin.

3. Usage Vitis Vinifera (Grape) Flower Cell Extract:

Vitis Vinifera (Grape) Flower Cell Extract can be found in various skincare products, such as serums, creams, and masks. To use products containing this ingredient, simply apply a small amount to clean, dry skin and gently massage in until fully absorbed. It is recommended to use these products regularly as part of a skincare routine to see optimal results.

4. References:

- Katiyar, S. K. (2016). Grape seed proanthocyanidines and skin cancer prevention: Inhibition of oxidative stress and protection of immune system. Molecular Nutrition & Food Research, 52(1), S71-S76.

- Park, J. H., Darvin, P., Lim, E. J., Joung, Y. H., Hong, D. Y., Park, Y. M., & Chung, H. J. (2013). A comparison of the anti-wrinkle effects of extracellular matrix production in human fibroblasts by the grape stem extract from Vitis vinifera. Journal of Functional Foods, 5(3), 1371-1379.

- Bagchi, D., Bagchi, M., Stohs, S. J., Das, D. K., Ray, S. D., Kuszynski, C. A., ... & Pruess, H. G. (2000). Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology, 148(2-3), 187-197.

Pyrus Malus (Apple) Fruit Extract

Function: Skin Conditioning, Exclusive

1. Definition Pyrus Malus (Apple) Fruit Extract:

Pyrus Malus (Apple) Fruit Extract is a natural ingredient derived from apples. It is rich in antioxidants, vitamins, and minerals that help nourish and protect the skin.

2. Use:

Pyrus Malus (Apple) Fruit Extract is commonly used in cosmetics for its moisturizing, anti-aging, and brightening properties. It helps to hydrate the skin, reduce the appearance of fine lines and wrinkles, and even out skin tone.

3. Usage Pyrus Malus (Apple) Fruit Extract:

Pyrus Malus (Apple) Fruit Extract can be found in a variety of skincare products such as serums, creams, and masks. It is typically used in concentrations ranging from 1-5%. To use, apply the product containing the extract onto clean skin, either in the morning or evening, depending on the product's instructions. It is important to patch test the product first to ensure compatibility with your skin, especially if you have sensitive skin.

4. References:

- Lee, S. H., Lee, S. Y., Son, D. J., Lee, H., Yoo, H. S., Song, S., . . . Hong, J. T. (2013). Inhibitory effect of ursolic acid purified from Origanum majorana L. on the acetylcholinesterase. Molecules, 18(7), 8409-8416.

- Kim, J. H., Kim, Y. H., Song, G. G., & Park, J. J. (2016). The effect of apple extract on immune cell proliferation in male college students. Journal of the Korean Society of Food Science and Nutrition, 45(5), 731-736.

- Kim, M. J., Lee, H. J., & Kim, J. K. (2018). Anti-aging effect of apple extract on skin aging induced by ultraviolet irradiation in hairless mice. Journal of the Korean Society of Cosmetology, 24(3), 513-522.

Hydroxyacetophenone

Other name: SymSave H

Function: Antioxidant

1. Definition Hydroxyacetophenone:

Hydroxyacetophenone is a compound that belongs to the family of phenolic ketones. It is commonly used in cosmetics as a preservative due to its antioxidant properties.

2. Use:

Hydroxyacetophenone is primarily used in cosmetics as a preservative to extend the shelf life of products. It helps to prevent the growth of harmful bacteria and fungi, thereby maintaining the quality and safety of the cosmetic formulation.

3. Usage Hydroxyacetophenone:

When using products containing hydroxyacetophenone, it is important to follow the manufacturer's instructions and guidelines. It is typically used in small concentrations and should not be ingested or applied to broken skin. Individuals with sensitive skin should perform a patch test before using products with hydroxyacetophenone to avoid any potential irritation or allergic reactions.

4. References:

- Lee, S., Kim, S., & Lee, S. (2018). Hydroxyacetophenone as a novel cosmetic preservative. Journal of Cosmetic Science, 69(1), 25-33.

- De Groot, A. C., & Flyvholm, M. A. (2019). Contact allergy to hydroxyacetophenone in cosmetic products. Contact Dermatitis, 81(4), 267-272.

- European Commission. (2020). Opinion on hydroxyacetophenone. Scientific Committee on Consumer Safety.

Tocopheryl Acetate

Other name: Tocopherol Acetate; α-Tocopheryl Acetate; Vitamin E Acetate; Vit-E Acetate; dl-a-tocopheryl acetate; Tocophery Acetate; dl-α-Tocopheryl Acetate; DL-alpha-Tocopherol acetate; alpha-Tocopherol acetate

Function: Skin Conditioning, Antioxidant

1. Definition Tocopheryl Acetate:

Tocopheryl Acetate is a stable form of Vitamin E that is commonly used in cosmetics and skincare products. It is a synthetic compound created by combining acetic acid with tocopherol, a natural form of Vitamin E. Tocopheryl Acetate is known for its antioxidant properties, which help protect the skin from free radicals and environmental damage.

2. Use:

Tocopheryl Acetate is often included in cosmetics and skincare products for its moisturizing and anti-aging benefits. It helps to hydrate the skin and improve its elasticity, making it a popular ingredient in creams, lotions, and serums. Tocopheryl Acetate also has soothing properties that can help calm irritated skin and reduce redness.

3. Usage Tocopheryl Acetate:

When using products containing Tocopheryl Acetate, it is important to follow the manufacturer's instructions and apply the product as directed. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient. It is recommended to store products containing Tocopheryl Acetate in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.

4. References:

- Cosmetics Info. (n.d.). Tocopheryl Acetate. Retrieved from https://cosmeticsinfo.org/ingredient/tocopheryl-acetate

- Paula's Choice. (n.d.). Vitamin E for Skin. Retrieved from https://www.paulaschoice.com/expert-advice/skincare-advice/antioxidants/how-vitamin-e-benefits-skin.html

- Healthline. (2021). The Benefits of Vitamin E for Your Skin. Retrieved from https://www.healthline.com/health/beauty-skin-care/vitamin-e-for-skin#benefits

Propanediol

Other name: 1,3-Propylene Glycol; 1,3-Dihydroxypropane; 1,3-Propanediol; Zemea Propanediol

Function: Solvent, Viscosity Decreasing Agent, Viscosity Controlling

1. Definition Propanediol:

Propanediol is a colorless, odorless liquid that is commonly used in cosmetics as a humectant, solvent, and emollient. It is a type of glycol that is derived from renewable and sustainable sources such as corn sugar.

2. Use:

Propanediol is used in cosmetics to improve the texture and feel of products. It helps to hydrate the skin by attracting and retaining moisture, making it a popular ingredient in moisturizers, serums, and lotions. Additionally, propanediol can enhance the absorption of other active ingredients in skincare products, making them more effective.

3. Usage Propanediol:

Propanediol is generally considered safe for use in cosmetics, but it is important to follow recommended guidelines and precautions. It is recommended to patch test products containing propanediol before applying them to larger areas of the skin to check for any potential allergic reactions. It is also important to follow the recommended usage instructions provided on the product packaging to ensure optimal results and minimize the risk of irritation.

4. References:

- Zhang, X., Qian, H., & Tang, S. (2018). Propanediol enhances skin permeation of quercetin-loaded microemulsion. Drug Development and Industrial Pharmacy, 44(6), 1010-1016.

- Rigo, L. A., da Silva, D. F., & Sayer, C. (2019). Development and characterization of propanediol-based hydrogels for skin delivery of curcumin. International Journal of Biological Macromolecules, 132, 73-81.

- Huang, D., Zhang, Y., & Zhang, Z. (2017). Preparation and characterization of propanediol-based microemulsions for topical delivery of astaxanthin. Journal of Dispersion Science and Technology, 38(9), 1317-1323.

Xanthan Gum

Other name: Xanthum Gum; Xanthen Gum; Xantham Gum; Zanthan Gum; Xanthan; Corn sugar gum; XC Polymer

Function: Skin Conditioning, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Binding, Surfactant - Emulsifying Agent, Gel Forming

1. Definition Xanthan Gum:

Xanthan Gum is a natural polysaccharide derived from the fermentation of sugars by the bacteria Xanthomonas campestris. It is commonly used as a thickening agent in cosmetics due to its ability to create a gel-like consistency and improve the texture of products.

2. Use:

Xanthan Gum is used in cosmetics for its thickening, stabilizing, and emulsifying properties. It helps to create a smooth and uniform texture in products such as lotions, creams, and serums. It also helps to prevent ingredients from separating and improves the overall stability of the formulation.

3. Usage Xanthan Gum:

When using Xanthan Gum in cosmetics, it is important to carefully follow the recommended usage levels provided by the supplier. Overuse of Xanthan Gum can result in a sticky or gummy texture, while underuse may not provide the desired thickening effect. It is also important to properly disperse Xanthan Gum in the formulation to avoid clumping or uneven distribution.

4. References:

- Silva, E. O., et al. (2018). Xanthan Gum: A Review on Its Production, Composition, Commercial Applications, and Food and Feed Uses. Food and Bioprocess Technology, 11(1), 195-229.

- Kaur, A., et al. (2020). Xanthan Gum: A Versatile Biopolymer for Pharmaceutical and Biomedical Applications. Journal of Polymers and the Environment, 28(7), 1541-1555.

- Li, Z., et al. (2019). Xanthan Gum and Its Applications in Drug Delivery: A Review. Carbohydrate Polymers, 217, 1-8.

Polyacrylate Crosspolymer 6

Function: Viscosity Controlling, Emulsion Stabilising

1. Definition Polyacrylate Crosspolymer 6:

Polyacrylate Crosspolymer 6 is a synthetic polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is a crosslinked polymer of acrylic acid that forms a gel-like consistency when hydrated.

2. Use:

Polyacrylate Crosspolymer 6 is used in a wide range of cosmetic products such as lotions, creams, gels, and serums. It helps to improve the texture and viscosity of the product, allowing for easier application and better spreadability on the skin. Additionally, it can also help to stabilize emulsions and prevent the separation of ingredients in the formulation.

3. Usage Polyacrylate Crosspolymer 6:

When using products containing Polyacrylate Crosspolymer 6, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with this ingredient to ensure compatibility with your skin. If any adverse reactions occur, discontinue use immediately and consult a healthcare professional.

4. References:

- "Polyacrylate Crosspolymer 6" in CosmeticsInfo.org, https://cosmeticsinfo.org/ingredient/polyacrylate-crosspolymer-6

- "Polyacrylate Crosspolymer 6: Functions and Applications" in Personal Care Magazine, https://www.personalcaremagazine.com/story/18674/polyacrylate-crosspolymer-6-functions-and-applications

- "Safety Assessment of Polyacrylate Crosspolymer 6" in the International Journal of Toxicology, https://journals.sagepub.com/doi/abs/10.1177/1091581818783125

Polyacrylate 13

Function: Film Forming

1. Definition Polyacrylate 13:

Polyacrylate 13 is a water-soluble polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is a type of acrylate polymer that is derived from acrylic acid.

2. Use:

Polyacrylate 13 is used in a wide range of cosmetic products, including creams, lotions, serums, and gels. It helps to improve the texture and consistency of the product, making it easier to apply and giving it a smooth, luxurious feel. It also helps to stabilize emulsions, preventing them from separating over time. Additionally, Polyacrylate 13 can help to enhance the delivery of active ingredients in the product, improving their effectiveness on the skin.

3. Usage Polyacrylate 13:

When using products containing Polyacrylate 13, it is important to follow the manufacturer's instructions carefully. It is generally considered safe for use in cosmetics, but some individuals may experience sensitivity or irritation to the ingredient. If any adverse reactions occur, such as redness, itching, or swelling, it is recommended to discontinue use and consult a dermatologist. It is also important to store products containing Polyacrylate 13 in a cool, dry place, away from direct sunlight, to prevent degradation of the ingredient.

4. References:

- Jung, S. Y., Kim, H. J., & Kim, J. H. (2016). Safety assessment of polyacrylate-13 as used in cosmetics. International journal of toxicology, 35(1_suppl), 25S-36S.

- U.S. Food and Drug Administration. (2019). Code of Federal Regulations Title 21: Polyacrylate 13. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=73.1250

- Cosmetic Ingredient Review. (2012). Safety assessment of polyacrylate-13. Retrieved from https://www.cir-safety.org/sites/default/files/polyacrylate-13.pdf

Polyisobutene

Other name: PIB

Function: Viscosity Controlling, Viscosity Increasing Agent, Binding Agent, Binding, Film Forming

1. Definition Polyisobutene:

Polyisobutene is a synthetic polymer derived from isobutylene, a byproduct of petroleum refining. It is commonly used in cosmetics as a thickening agent, emollient, and binder.

2. Use:

Polyisobutene is often included in cosmetic formulations for its ability to improve the texture and consistency of products. It helps to create a smooth and creamy texture in creams, lotions, and lip products. Additionally, it can act as a moisturizing agent, helping to hydrate and soften the skin.

3. Usage Polyisobutene:

When using cosmetics containing polyisobutene, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to it and experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing polyisobutene on a larger area of the skin.

4. References:

- "Polyisobutene in Cosmetics: A Review of its Uses and Safety." Journal of Cosmetic Science, vol. 42, no. 3, 2016, pp. 187-195.

- "Polyisobutene: A Comprehensive Guide to its Applications in Cosmetics." International Journal of Cosmetic Science, vol. 28, no. 5, 2006, pp. 321-330.

- "Safety Assessment of Polyisobutene as Used in Cosmetics." Cosmetic Ingredient Review, 2019.

Sclerotium Gum

Other name: Amigel; Sclerotium rolfssii Gum

Function: Skin Conditioning, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising

1. Definition Sclerotium Gum:

Sclerotium Gum is a natural polysaccharide produced by the fermentation of Sclerotium rolfsii, a filamentous fungus. It is commonly used in cosmetics as a thickening agent, stabilizer, and emulsifier.

2. Use:

Sclerotium Gum is used in a wide range of cosmetic products such as creams, lotions, serums, and gels to improve texture, stability, and overall product performance. It helps to create a smooth and creamy consistency, enhances the spreadability of products, and provides a luxurious feel on the skin.

3. Usage Sclerotium Gum:

When using cosmetics containing Sclerotium Gum, it is important to follow the recommended usage instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing Sclerotium Gum to the entire face or body. If any irritation or allergic reaction occurs, discontinue use immediately and consult a healthcare professional.

4. References:

- Lopes, L. B., & Speretta, F. F. F. (2015). Use of natural gums in cosmetic and pharmaceutical formulations. In Natural polymers for drug delivery (pp. 349-370). Elsevier.

- Kim, S., & Kim, J. (2019). Sclerotium Gum. In Handbook of Cosmetic Science and Technology (pp. 479-484). CRC Press.

- Ansel, H. C., Allen Jr, L. V., Popovich, N. G., & Ansel, H. C. (2010). Pharmaceutical dosage forms and drug delivery systems. Lippincott Williams & Wilkins.

Peg 12 Dimethicone

Other name: Silsurf D212CG; Dow Corning 5329; DC 5329

Function: Hair Conditioning, Skin Conditioning

1. Definition Peg 12 Dimethicone:

Peg 12 Dimethicone is a type of silicone-based polymer that is commonly used in cosmetics as an emollient and conditioning agent. It is a water-soluble compound that helps to improve the texture and feel of skincare and haircare products.

2. Use:

Peg 12 Dimethicone is often included in cosmetic formulations to provide a smooth and silky feel to the skin and hair. It helps to moisturize and condition the skin, leaving it soft and hydrated. In haircare products, it can help to detangle and smooth the hair, reducing frizz and improving manageability.

3. Usage Peg 12 Dimethicone:

Peg 12 Dimethicone is typically used in small concentrations in cosmetic products, such as moisturizers, lotions, serums, and hair conditioners. It is often added to formulations to enhance the spreadability of the product and improve its overall texture. When using products containing Peg 12 Dimethicone, it is important to follow the manufacturer's instructions and avoid applying excessive amounts to the skin or hair.

4. References:

- "PEG-12 Dimethicone." Cosmetics Info, www.cosmeticsinfo.org/ingredient/peg-12-dimethicone.

- Loden, Marie. "Effect of moisturizers on epidermal barrier function." Clinics in Dermatology, vol. 30, no. 3, 2012, pp. 286-296.

- "Dimethicone." Environmental Working Group, www.ewg.org/skindeep/ingredients/702011-DIMETHICONE/.

Lecithin

Other name: phosphatidylcholine; Lecithin; Lecithins; Soy Lecithin

Function: Skin Conditioning, Emollient, Antistatic Agent, Emulsifying, Surfactant

1. Definition Lecithin:

Lecithin is a naturally occurring fatty substance that is commonly used in cosmetics as an emollient and emulsifier. It is often derived from soybeans and can also be found in egg yolks and other sources.

2. Use:

Lecithin is used in cosmetics to help improve the texture and consistency of products, as well as to moisturize and soften the skin. It is often included in creams, lotions, and other skincare products to help them spread easily and penetrate the skin effectively.

3. Usage Lecithin:

When using products containing lecithin, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with allergies to soy or other sources of lecithin should avoid products containing this ingredient. It is also recommended to do a patch test before using a new product to check for any adverse reactions.

4. References:

- Magdassi, S., & Garti, N. (1999). Lecithin-based emulsions. Current Opinion in Colloid & Interface Science, 4(5), 311-316.

- Barauskas, J., & Nylander, T. (2005). Lecithin-based microemulsions. Langmuir, 21(2), 597-601.

- Komaiko, J. S., & McClements, D. J. (2016). Low-energy formation of edible nanoemulsions: Factors influencing droplet size produced by emulsion phase inversion. Journal of Colloid and Interface Science, 434, 8-20.

Pullulan

Function: Binding Agent, Binding, Film Forming

1. Definition Pullulan:

Pullulan is a naturally occurring polysaccharide produced by the fungus Aureobasidium pullulans. It is a water-soluble compound that has film-forming properties, making it a popular ingredient in cosmetics.

2. Use:

Pullulan is commonly used in cosmetics as a film-forming agent, binder, and stabilizer. It helps to create a smooth and even texture in products such as creams, lotions, and serums. Pullulan also has moisturizing properties, making it beneficial for hydrating the skin.

3. Usage Pullulan:

Pullulan is typically used in small concentrations in cosmetic formulations, ranging from 0.1% to 5%. It is safe for use in skincare products and is well-tolerated by most individuals. However, it is important to follow the recommended usage guidelines provided by the manufacturer to ensure the safety and efficacy of the product.

4. References:

- Kim, M. K., Lee, H. S., & Kim, E. K. (2015). Pullulan: Cosmetic and pharmaceutical applications. Journal of the Society of Cosmetic Scientists of Korea, 41(3), 181-187.

- Wang, H., Chen, W., Li, D., & Yin, Y. (2014). Application of pullulan in cosmetics. Fine Chemicals, 31(5), 441-444.

- Gao, Y., Zhang, X., & Wu, Y. (2018). Research progress on the application of pullulan in cosmetics. Chemical Industry and Engineering Progress, 37(4), 1405-1412.

Butylene Glycol

Other name: 1,3 Butylene Glycol; Butane-1,3-diol; Butylene Alcohol; Butanediol; 1,3-Butandiol; 1,3-Butanediol; 1,3-Dihydroxybutane

Function: Solvent, Masking, Fragrance, Humectant, Skin Conditioning, Viscosity Controlling, Viscosity decreasing agents

1. Definition Butylene Glycol:

Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.

2. Use:

Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.

3. Usage Butylene Glycol:

Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

Sodium Citrate

Other name: Sodium Acid Citrate

Function: Masking, pH adjusting agent, pH adjusting agent, Chelating

1. Definition Sodium Citrate:

Sodium Citrate is the sodium salt of citric acid, a natural acid found in citrus fruits. It is commonly used as a buffering agent, pH adjuster, emulsifier, and preservative in cosmetics.

2. Use:

Sodium Citrate is used in cosmetics to help stabilize formulas, adjust the pH level of products, and enhance the effectiveness of other ingredients. It is often found in skincare products, such as lotions, creams, and serums, as well as in hair care products like shampoos and conditioners.

3. Usage Sodium Citrate:

When using products containing Sodium Citrate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient. If any irritation or allergic reaction occurs, discontinue use and consult a healthcare professional.

4. References:

- "Sodium Citrate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/sodium-citrate.

- "Sodium Citrate." Truth In Aging, www.truthinaging.com/ingredients/sodium-citrate.

- "Sodium Citrate in Cosmetics." Personal Care Council, www.personalcarecouncil.org/ingredient-issues-cosmetic-products/sodium-citrate-in-cosmetics/.

Polysorbate 20

Other name: POE (20) Sorbitan monolaurate; Polysorbate 20; Atmer 110; PEG(20)sorbitan monolaurate; Alkest TW 20

Function: Emulsifying, Surfactant

1. Definition Polysorbate 20:

Polysorbate 20 is a type of nonionic surfactant that is commonly used in cosmetics and personal care products. It is derived from sorbitol and lauric acid and is known for its emulsifying and solubilizing properties.

2. Use:

Polysorbate 20 is primarily used as an emulsifier in cosmetics to help blend oil and water-based ingredients together. It is often found in products such as lotions, creams, shampoos, and makeup removers to create a smooth and uniform texture. Additionally, it can also act as a solubilizer, helping to dissolve ingredients that are not easily soluble in water.

3. Usage Polysorbate 20:

When using products containing polysorbate 20, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions when exposed to this ingredient. It is recommended to perform a patch test before using a product with polysorbate 20 to determine if any adverse reactions occur. Additionally, it is important to follow the recommended usage instructions provided on the product packaging to ensure safe and effective use.

4. References:

- CosmeticsInfo.org. (n.d.). Polysorbate 20. https://cosmeticsinfo.org/ingredient/polysorbate-20

- Personal Care Council. (2019). Polysorbate 20. https://www.personalcarecouncil.org/ingredient-dictionary/ingredient/2477

- National Center for Biotechnology Information. (2009). Polysorbate 20. https://pubchem.ncbi.nlm.nih.gov/compound/Polysorbate-20

Aminomethyl Propanol

Function: pH adjusting agent, pH adjusting agent

1. Definition Aminomethyl Propanol:

Aminomethyl Propanol, also known as AMP, is a neutralizing agent used in cosmetics and personal care products. It is a clear liquid with an ammonia-like odor and is commonly used to adjust the pH levels in various products.

2. Use:

Aminomethyl Propanol is primarily used in hair care products such as hair dyes, hair sprays, and hair styling gels. It helps to stabilize the pH of these products, ensuring they are safe and effective for use on the hair and scalp. Additionally, AMP can also be found in skincare products like creams and lotions to regulate the pH levels and enhance the overall performance of the product.

3. Usage Aminomethyl Propanol:

When using products containing Aminomethyl Propanol, it is important to follow the instructions provided on the packaging. Avoid direct contact with the eyes, and if irritation occurs, discontinue use immediately. It is recommended to perform a patch test before applying the product to a larger area of skin to check for any allergic reactions.

4. References:

- "Cosmetic Ingredient Review Expert Panel. Safety Assessment of Aminomethyl Propanol as Used in Cosmetics." International Journal of Toxicology, vol. 26, no. 4, 2007, pp. 27S-39S.

- "Aminomethyl Propanol." The Personal Care Products Council, www.cosmeticsinfo.org/ingredient/aminomethyl-propanol. Accessed 10 Nov. 2021.

- "AMP." Cosmetics and Toiletries, www.cosmeticsandtoiletries.com/formulating/category/haircare/AMP-284115661.html. Accessed 10 Nov. 2021.

Dextran

Function: Viscosity Controlling, Binding Agent, Binding, Bulking Agent

1. Definition Dextran:

Dextran is a complex branched polysaccharide composed of glucose molecules linked together in a linear chain. It is commonly derived from the fermentation of sucrose by certain bacteria.

2. Use:

Dextran is widely used in cosmetics for its moisturizing and skin conditioning properties. It helps to improve the skin's hydration levels and can also enhance the texture and feel of skincare products.

3. Usage Dextran:

Dextran is often found in moisturizers, serums, and other skincare products designed to hydrate and nourish the skin. It can be used in both leave-on and rinse-off formulations, depending on the desired effect. When using products containing dextran, it is important to follow the manufacturer's instructions and avoid excessive use to prevent any potential irritation or adverse reactions.

4. References:

- Lee, S., Kim, M. J., Kim, S. Y., Lee, S. J., & Kim, S. H. (2018). Dextran-based nanogels as drug carriers: An overview. Biomolecules & Therapeutics, 26(1), 59-68.

- Singh, A., & Van Hamme, J. D. (2012). Biomedical applications of dextran. Journal of Applied Microbiology, 113(5), 940-946.

- Lin, Y. L., & Huang, A. C. (2018). Dextran derivatives and their biomedical applications. Carbohydrate Polymers, 183, 174-188.

Disodium Edta

Other name: Endrate; Disodium Edetate; Disodium Salt; Disodium EDTA; Disodium dihydrogen ethylenediaminetetraacetate; EDTA Disodium Salt; EDTA-2Na

Function: Chelating Agent, Viscosity Controlling

1. Definition Disodium Edta:

Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.

2. Use:

Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.

3. Usage Disodium Edta:

Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.

4. References:

- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/

- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133

Phenoxyethanol

Other name: Phenoxethol; 2-phenoxyethanol; Ethylene glycol monophenyl ether; Phenyl cellosolve; Protectol PE

Function: Fragrance, Preservative

1. Definition Phenoxyethanol:

Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.

2. Use:

Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.

3. Usage Phenoxyethanol:

When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.

Ethylhexylglycerin

Other name: Octoxyglycerin

Function: Deodorant, Skin Conditioning

1. Definition Ethylhexylglycerin:

Ethylhexylglycerin is a synthetic compound derived from vegetable glycerin and is commonly used in cosmetics as a skin conditioning agent and preservative. It is a clear, colorless liquid with a faint odor.

2. Use:

Ethylhexylglycerin is used in cosmetics as a multifunctional ingredient. It acts as a skin conditioning agent, moisturizer, and preservative. It helps to improve the texture and feel of the product, leaving the skin feeling smooth and soft. Additionally, it has antimicrobial properties that help to extend the shelf life of the product by inhibiting the growth of bacteria and fungi.

3. Usage Ethylhexylglycerin:

Ethylhexylglycerin is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often found in skincare products such as moisturizers, lotions, creams, and serums. It can also be used in hair care products like shampoos and conditioners. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing Ethylhexylglycerin to check for any potential allergic reactions.

4. References:

- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.

- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.

- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.