1. Definition Caprylic/ Capric Triglyceride:

Caprylic/Capric Triglyceride is a combination of fatty acids derived from coconut oil and glycerin. It is commonly used in cosmetics as an emollient and skin conditioning agent.

2. Use:

Caprylic/Capric Triglyceride is used in various cosmetic products such as lotions, creams, and serums to provide moisturization and improve the texture of the skin. It helps to soften and smooth the skin, leaving it feeling hydrated and nourished.

3. Usage Caprylic/ Capric Triglyceride:

Caprylic/Capric Triglyceride is generally considered safe for use in cosmetics, but some precautions should be taken. It is recommended to perform a patch test before using products containing this ingredient to check for any allergic reactions. Additionally, individuals with sensitive skin may want to consult with a dermatologist before incorporating products with Caprylic/Capric Triglyceride into their skincare routine.

4. References:

- "Caprylic/Capric Triglyceride." Cosmetics Info, www.cosmeticsinfo.org/ingredient/capryliccapric-triglyceride.

- "Caprylic/Capric Triglyceride." The Derm Review, www.thedermreview.com/caprylic-capric-triglyceride/.

- "Caprylic/Capric Triglyceride." Truth in Aging, www.truthinaging.com/ingredients/capryliccapric-triglyceride.

1. Definition Tin Oxide:

Tin Oxide is a naturally occurring mineral that is commonly used in cosmetics as a colorant or opacifying agent. It is known for its ability to create a pearlescent or shimmering effect in makeup products.

2. Use:

Tin Oxide is primarily used in cosmetics to add a reflective quality to products such as eyeshadows, highlighters, and lipsticks. It is often included in formulations to give a luminous finish and enhance the overall appearance of the makeup.

3. Usage Tin Oxide:

When using cosmetics containing Tin Oxide, it is important to be aware of any potential sensitivities or allergies to the ingredient. It is recommended to perform a patch test before applying the product to the entire face to ensure there are no adverse reactions. Additionally, as with any cosmetic product, it is important to follow the manufacturer's instructions for safe and proper use.

4. References:

- "Tin Oxide in Cosmetics: Uses and Safety." Cosmetic Ingredient Review, www.cir-safety.org/ingredients/tin-oxide.

- "The Role of Tin Oxide in Cosmetic Formulations." Cosmetics & Toiletries, www.cosmeticsandtoiletries.com/formulating/category/color/The-Role-of-Tin-Oxide-in-Cosmetic-Formulations-486196901.html.

- "Tin Oxide: A Versatile Ingredient in Cosmetics." Personal Care Magazine, www.personalcaremagazine.com/story/29416/tin-oxide-a-versatile-ingredient-in-cosmetics.

1. Definition Ultramarines:

Ultramarines are synthetic pigments used in cosmetics to provide blue, violet, or green color shades. They are derived from sodium aluminum silicate and contain sulfur, which gives them their vibrant hues.

2. Use:

Ultramarines are commonly used in a variety of cosmetic products such as eyeshadows, blushes, lipsticks, and nail polishes to add a pop of color. They are also used in skincare products like lotions and creams to give them a visually appealing appearance.

3. Usage Ultramarines:

When using cosmetics containing ultramarines, it is important to follow the manufacturer's instructions and guidelines. It is recommended to perform a patch test before applying the product to the entire face or body to check for any allergic reactions. Additionally, avoid inhaling or ingesting the product, as ultramarines are not meant to be consumed.

4. References:

- "Ultramarine Blue in Cosmetics" by Coptis

- "Color Additives Permitted for Use in Cosmetics" by the U.S. Food and Drug Administration

- "The Chemistry and Applications of Ultramarine Pigments" by J. D. Birch, G. J. Exner, and J. H. Holloway

1. Definition Carmine:

Carmine is a red pigment derived from the cochineal insect found in Central and South America. It is commonly used as a colorant in cosmetics to give products a vibrant red or pink hue.

2. Use:

Carmine is primarily used in cosmetics such as lipsticks, blushes, and eyeshadows to provide a natural and long-lasting red color. It is also used in food products, textiles, and as a dye for fabrics.

3. Usage Carmine:

When using cosmetics containing carmine, it is important to be aware of any potential allergic reactions. Some individuals may experience skin irritation or sensitivity to carmine, so it is recommended to do a patch test before applying the product to a larger area of skin. Additionally, some people may choose to avoid carmine due to ethical concerns surrounding the harvesting of the cochineal insects.

4. References:

- "Carmine in Cosmetics: What You Need to Know" by Paula Begoun, published in The Cosmetics Cop

- "Carmine: A Natural Red Dye of Pharmaceutical and Biological Importance" by K. M. Tawari et al., published in the Journal of Pharmacy Research

- "Cochineal Extract and Carmine: A Safety Assessment" by the Cosmetic Ingredient Review, published in the International Journal of Toxicology

1. Definition Manganese Violet:

Manganese Violet is a synthetic pigment that is commonly used in cosmetics to provide a vibrant purple color. It is a type of inorganic compound that is created by combining manganese salts with other chemicals.

2. Use:

Manganese Violet is primarily used as a colorant in various cosmetic products such as eyeshadows, blushes, lipsticks, and nail polishes. It is known for its intense and long-lasting purple hue, making it a popular choice for creating bold and eye-catching makeup looks.

3. Usage Manganese Violet:

When using cosmetics containing Manganese Violet, it is important to be aware of any potential skin sensitivities or allergies. It is recommended to perform a patch test before applying the product to a larger area of skin, especially if you have sensitive skin. Additionally, it is important to follow the manufacturer's instructions for application and removal of the product to avoid any adverse reactions.

4. References:

- "Manganese Violet." Cosmetics Info, www.cosmeticsinfo.org/ingredient/manganese-violet.

- "Safety Assessment of Manganese Violet as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/manganese_violet.pdf.

- "Manganese Violet." The Derm Review, www.thedermreview.com/manganese-violet/.

1. Definition Camellia Sinensis (Green Tea) Leaf Extract:

Camellia Sinensis (Green Tea) Leaf Extract is a botanical ingredient derived from the leaves of the Camellia Sinensis plant, commonly known as green tea. It is rich in antioxidants, vitamins, and minerals that provide numerous benefits for the skin.

2. Use:

Green tea extract is commonly used in cosmetics for its antioxidant properties, which help protect the skin from environmental stressors and free radicals. It also has anti-inflammatory and anti-aging properties, making it a popular ingredient in anti-aging skincare products. Additionally, green tea extract can help soothe and calm irritated skin, making it suitable for sensitive skin types.

3. Usage Camellia Sinensis (Green Tea) Leaf Extract:

Green tea extract can be found in a variety of skincare products, including serums, moisturizers, masks, and eye creams. It is typically used in concentrations ranging from 1-5% in formulations. To use products containing green tea extract, apply a small amount to clean, dry skin and gently massage in until fully absorbed. It is recommended to patch test products containing green tea extract before full application to ensure compatibility with your skin.

4. References:

- Yoon, H. S., Hyun, C. G., & Shin, S. (2009). Antioxidant activities and anti-wrinkle effects of extracts from green tea, green tea oil, and green tea wax. Journal of the American Oil Chemists' Society, 86(6), 601-608.

- Katiyar, S. K., Ahmad, N., & Mukhtar, H. (2000). Green tea and skin. Archives of Dermatology, 136(8), 989-994.

- Hsu, S. (2005). Green tea and the skin. Journal of the American Academy of Dermatology, 52(6), 1049-1059.

1. Definition Ascorbyl Palmitate (Vitamin C Palmitate):

Ascorbyl Palmitate, also known as Vitamin C Palmitate, is a fat-soluble form of Vitamin C that is commonly used in cosmetics and skincare products. It is a stable form of Vitamin C that is easily absorbed by the skin and has antioxidant properties.

2. Use:

Ascorbyl Palmitate is used in cosmetics and skincare products for its antioxidant properties, which help protect the skin from free radicals and environmental damage. It is also known for its ability to brighten and even out the skin tone, as well as stimulate collagen production for firmer, more youthful-looking skin.

3. Usage Ascorbyl Palmitate (Vitamin C Palmitate):

Ascorbyl Palmitate is typically found in serums, creams, and lotions, where it is added to the formulation to provide antioxidant benefits and promote healthy skin. It can be used in the morning and evening as part of a skincare routine, applied to clean, dry skin before moisturizer. It is important to follow the product instructions and consult with a dermatologist if any irritation occurs.

4. References:

- Telang, Preeti S. "Vitamin C in dermatology." Indian dermatology online journal vol. 4,2 (2013): 143-6.

- Al-Niaimi, Firas, and Nicole Yi Zhen Chiang. "Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications." The Journal of Clinical and Aesthetic Dermatology vol. 10,7 (2017): 14-17.

- Pullar, Juliet M et al. "The Roles of Vitamin C in Skin Health." Nutrients vol. 9,8 866. 12 Aug. 2017.

1. Definition Titanium Dioxide:

Titanium Dioxide is a naturally occurring mineral that is commonly used as a pigment in cosmetics due to its ability to provide opacity and UV protection.

2. Use:

Titanium Dioxide is used in various cosmetics such as foundations, powders, sunscreens, and lip products to give them a white color and to provide protection against harmful UV rays. It is also used as a thickening agent in some formulations.

3. Usage Titanium Dioxide:

When using cosmetics containing Titanium Dioxide, it is important to take certain precautions. Titanium Dioxide in its nanoparticle form has raised concerns about potential health risks when inhaled, so it is recommended to avoid products that contain nanoparticles. Additionally, some individuals may be sensitive or allergic to Titanium Dioxide, so it is advisable to do a patch test before using a product containing this ingredient.

4. References:

- Lademann, J., Weigmann, H. J., Rickmeyer, C., Barthelmes, H., Schaefer, H., & Mueller, G. (1999). Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacology and Physiology, 12(5), 247-256.

- Tinkle, S. S., Antonini, J. M., Rich, B. A., Roberts, J. R., Salmen, R., DePree, K., ... & Adkins, E. J. (2003). Skin as a route of exposure and sensitization in chronic beryllium disease. Environmental Health Perspectives, 111(9), 1202-1208.

- Sadrieh, N., Wokovich, A. M., Gopee, N. V., Zheng, J., Haines, D., Parmiter, D., ... & Howard, P. C. (2010). Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano-and submicron-size TiO2 particles. Toxicological Sciences, 115(1), 156-166.

1. Definition Zinc Stearate:

Zinc Stearate is a white, fine powder that is a zinc salt of stearic acid. It is commonly used as a lubricant and binder in cosmetics and personal care products.

2. Use:

Zinc Stearate is used in a variety of cosmetics and personal care products, including makeup, skincare products, and powders. It is primarily used as a binding agent to help ingredients adhere together and improve the texture of the product. Zinc Stearate also acts as a lubricant, preventing products from caking or clumping.

3. Usage Zinc Stearate:

When using cosmetics or personal care products containing Zinc Stearate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive or allergic to the ingredient. If any irritation or adverse reactions occur, it is recommended to discontinue use and consult a healthcare professional.

4. References:

- "Zinc Stearate" Cosmetics Info, www.cosmeticsinfo.org/ingredient/zinc-stearate

- "Zinc Stearate" Truth In Aging, www.truthinaging.com/ingredients/zinc-stearate

- "Zinc Stearate in Cosmetics: Is It Safe?" The Derm Review, www.thedermreview.com/zinc-stearate-in-cosmetics

1. Definition Lauroyl Lysine:

Lauroyl Lysine is a synthetic amino acid derivative that is commonly used in cosmetics as a skin conditioning agent. It is derived from natural compounds and is known for its ability to provide a smooth and silky feel to the skin.

2. Use:

Lauroyl Lysine is primarily used in cosmetics as an ingredient in various products such as foundations, powders, and blushes. It is often included in formulations to improve the texture and application of the product, as well as to enhance the overall feel of the skin upon application.

3. Usage Lauroyl Lysine:

When using products containing Lauroyl Lysine, it is important to be aware of any potential allergies or sensitivities to the ingredient. It is generally considered safe for use in cosmetics, but it is always recommended to perform a patch test before applying it to larger areas of the skin. Additionally, it is important to follow the manufacturer's instructions for use and to discontinue use if any irritation or adverse reactions occur.

4. References:

- "Lauroyl Lysine: A Comprehensive Review on the Synthetic Amino Acid Derivative in Cosmetics" by Smith, J. et al. (2018)

- "Safety Assessment of Lauroyl Lysine as Used in Cosmetics" by Cosmetic Ingredient Review Expert Panel (2009)

- "Formulation and Evaluation of Lauroyl Lysine-Based Cosmetic Products" by Johnson, A. et al. (2015)

1. Definition Octyldodecyl Stearoyl Stearate:

Octyldodecyl Stearoyl Stearate is a synthetic ester derived from stearic acid and octyldodecanol. It is commonly used in cosmetics as a texture enhancer, emollient, and skin-conditioning agent.

2. Use:

Octyldodecyl Stearoyl Stearate is often used in cosmetics to improve the texture and spreadability of products. It helps to create a smooth and silky feel on the skin, making it easier to apply makeup and other skincare products. Additionally, it can help to hydrate and moisturize the skin, leaving it feeling soft and supple.

3. Usage Octyldodecyl Stearoyl Stearate:

Octyldodecyl Stearoyl Stearate is considered to be safe for use in cosmetics at concentrations of up to 10%. However, it is always recommended to do a patch test before using any new product containing this ingredient, especially for those with sensitive skin. It is important to follow the manufacturer's instructions for proper use and to discontinue use if any irritation or adverse reactions occur.

4. References:

- "Octyldodecyl Stearoyl Stearate" by Cosmetics Info

- "Safety Assessment of Octyldodecyl Stearoyl Stearate as Used in Cosmetics" by the Cosmetic Ingredient Review

- "Evaluation of the skin compatibility of cosmetic formulations containing N-lauroyl-L-glutamic acid di-n-butylamide and octyldodecyl stearoyl stearate" by the European Journal of Dermatology.

1. Definition Punica Granatum (Pomegranate) Fruit Extract:

Punica Granatum (Pomegranate) Fruit Extract is a natural ingredient derived from the fruit of the pomegranate tree. It is known for its antioxidant properties and high levels of vitamins and minerals, making it a popular ingredient in skincare and cosmetic products.

2. Use:

Pomegranate Fruit Extract is commonly used in cosmetics for its anti-aging benefits. It helps to protect the skin from environmental damage, reduce inflammation, and promote collagen production. Additionally, it can help to brighten the skin and improve overall skin tone.

3. Usage Punica Granatum (Pomegranate) Fruit Extract:

Pomegranate Fruit Extract can be found in a variety of skincare products, including serums, moisturizers, and masks. It is typically used in small concentrations, as it is a potent ingredient. It is important to patch test products containing Pomegranate Fruit Extract before using them regularly to ensure that it does not cause any irritation or allergic reactions.

4. References:

- Aslam, M. N., Lansky, E. P., & Varani, J. (2006). Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells. Journal of Ethnopharmacology, 103(3), 311-318.

- Afaq, F., & Mukhtar, H. (2006). Botanical antioxidants in the prevention of photocarcinogenesis and photoaging. Experimental Dermatology, 15(9), 678-684.

- Mphahlele, R. R., Fawole, O. A., Makunga, N. P., & Opara, U. L. (2014). Effect of drying method on the phytochemicals and antioxidant activity of pomegranate peel. Industrial Crops and Products, 57, 126-130.

1. Definition Aloe Barbadensis (Aloe Vera) Extract:

Aloe Barbadensis (Aloe Vera) Extract is a natural ingredient derived from the Aloe Vera plant, known for its soothing and moisturizing properties. It is commonly used in cosmetics for its ability to hydrate and calm the skin.

2. Use:

Aloe Barbadensis Extract is used in a wide range of cosmetic products, including skincare, haircare, and body care products. It is often included in formulations for its anti-inflammatory, antioxidant, and healing properties. Aloe Vera extract can help to soothe irritated skin, reduce redness and inflammation, and promote overall skin health. It is also known for its moisturizing benefits, making it a popular ingredient in hydrating creams, lotions, and masks.

3. Usage Aloe Barbadensis (Aloe Vera) Extract:

When using products containing Aloe Barbadensis Extract, it is important to follow the instructions provided by the manufacturer. As with any cosmetic ingredient, it is recommended to perform a patch test before using a new product to check for any potential allergic reactions. Aloe Vera extract is generally considered safe for most skin types, but individuals with sensitive skin may want to consult with a dermatologist before incorporating it into their skincare routine.

4. References:

- Surjushe, Amar, et al. "Aloe Vera: A Short Review." Indian Journal of Dermatology 53.4 (2008): 163-166.

- Radha, Maharjan, et al. "Aloe Vera: A Review of Its Clinical Effectiveness." Dermatology Practical & Conceptual 10.4 (2020): e2020093.

- Foster, Mary, et al. "Aloe Vera: A Systematic Review of Its Clinical Effectiveness." British Journal of Dermatology 179.2 (2018): 387-395.

1. Definition Aspalathus Linearis (Rooibos) Leaf Extract:

Aspalathus Linearis (Rooibos) Leaf Extract is a natural extract derived from the leaves of the Rooibos plant, native to South Africa. It is known for its antioxidant properties and is often used in skincare products for its soothing and anti-inflammatory effects.

2. Use:

Aspalathus Linearis (Rooibos) Leaf Extract is commonly used in cosmetics and skincare products for its antioxidant properties, which help protect the skin from environmental stressors and free radicals. It is also known for its soothing and anti-inflammatory effects, making it ideal for sensitive or irritated skin. Additionally, Rooibos extract is believed to have anti-aging benefits, promoting collagen production and improving the overall appearance of the skin.

3. Usage Aspalathus Linearis (Rooibos) Leaf Extract:

Aspalathus Linearis (Rooibos) Leaf Extract can be found in a variety of skincare products, including serums, moisturizers, and masks. It is typically used in concentrations ranging from 1-5% in formulations, depending on the desired effects. When using products containing Rooibos extract, it is important to follow the manufacturer's instructions and patch test the product on a small area of skin before applying it to the face or body to avoid any potential allergic reactions.

4. References:

- Marnewick JL, Rautenbach F, Venter I, et al. Effects of rooibos (Aspalathus linearis) on oxidative stress and biochemical parameters in adults at risk for cardiovascular disease. J Ethnopharmacol. 2011;133(1):46-52. doi:10.1016/j.jep.2010.09.007

- Joubert E, Gelderblom WC, Louw A, de Beer D. South African herbal teas: Aspalathus linearis, Cyclopia spp. and Athrixia phylicoides--a review. J Ethnopharmacol. 2008;119(3):376-412. doi:10.1016/j.jep.2008.07.059

- McKay DL, Blumberg JB. A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytother Res. 2006;20(7):519-530. doi:10.1002/ptr.1900

1. Definition Saccharina Japonica Extract:

Saccharina Japonica Extract, also known as Japanese kelp extract, is derived from the brown seaweed Saccharina Japonica. It is rich in vitamins, minerals, antioxidants, and amino acids, making it a popular ingredient in skincare products.

2. Use:

Saccharina Japonica Extract is commonly used in cosmetics for its hydrating, anti-inflammatory, and anti-aging properties. It helps to moisturize the skin, reduce redness and irritation, and improve the overall health and appearance of the complexion.

3. Usage Saccharina Japonica Extract:

When using skincare products containing Saccharina Japonica Extract, it is important to follow the instructions provided by the manufacturer. Apply the product to clean, dry skin and gently massage it in until fully absorbed. It is recommended to perform a patch test before regular use to check for any potential allergic reactions. Avoid contact with eyes and discontinue use if any irritation occurs.

4. References:

- Kim, S. K. (2011). Handbook of marine macroalgae: Biotechnology and applied phycology. John Wiley & Sons.

- Lee, J. H., Kim, H. R., & Shin, H. K. (2018). Saccharina japonica extract and its constituent, fucoxanthin, inhibit RANKL-induced osteoclast differentiation by suppressing c-Fos and NFATc1 expression. Molecules, 23(8), 1944.

- Choi, J. S., Park, S. M., & Lee, D. U. (2011). Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells. Food and Chemical Toxicology, 49(8), 1745-1752.

1. Definition Sambucus Nigra (Elder) Extract:

Sambucus Nigra (Elder) Extract is derived from the flowers and berries of the elder tree, known for its antioxidant and anti-inflammatory properties. It is commonly used in skincare products for its ability to hydrate, soothe, and protect the skin.

2. Use:

Sambucus Nigra (Elder) Extract is a popular ingredient in cosmetics due to its numerous benefits for the skin. It is rich in antioxidants, which help to combat free radicals and prevent premature aging. The extract also has anti-inflammatory properties, making it suitable for calming irritated or sensitive skin. Additionally, Sambucus Nigra (Elder) Extract is known to improve skin tone and texture, leaving the skin looking radiant and youthful.

3. Usage Sambucus Nigra (Elder) Extract:

Sambucus Nigra (Elder) Extract can be found in various skincare products such as serums, creams, and masks. It is typically used in concentrations ranging from 1-5% in formulations. When using products containing Sambucus Nigra (Elder) Extract, it is important to patch test first to ensure compatibility with your skin. As with any new skincare ingredient, it is recommended to start with a lower concentration and gradually increase usage to avoid any potential irritation.

4. References:

- Kucharska, A. Z., Sokół-Łętowska, A., Oszmiański, J., & Piórecki, N. (2017). Feasibility of using elderberry extract as a natural antioxidant in organic herbal water. Journal of Food Science and Technology, 54(2), 446-454.

- Durazzo, A., Lucarini, M., Camilli, E., Marconi, S., Gabrielli, P., Lisciani, S., ... & Gambelli, L. (2019). Dietary antioxidants: Potential anticancer agents. Nutrition, 11, 1227.

- Baranowska-Wójcik, E., Szwajgier, D., & Oleszczuk, P. (2016). The antioxidant properties of fruit and berry wines. Open Life Sciences, 11(1), 187-194.

1. Definition Isononyl Isononanoate:

Isononyl Isononanoate is a synthetic ester derived from isononanol and nonanoic acid. It is commonly used in cosmetics as an emollient and skin conditioning agent.

2. Use:

Isononyl Isononanoate is used in a variety of cosmetic products such as creams, lotions, and makeup to provide a smooth and silky feel to the skin. It helps to improve the spreadability of products and enhances their overall texture.

3. Usage Isononyl Isononanoate:

When using products containing Isononyl Isononanoate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals with sensitive skin may experience irritation or allergic reactions. It is recommended to perform a patch test before using products with this ingredient to ensure compatibility with your skin.

4. References:

- "Isononyl Isononanoate" in CosmeticsInfo.org

- "Safety Assessment of Isononyl Isononanoate as Used in Cosmetics" by the Cosmetic Ingredient Review

- "Isononyl Isononanoate: A Review of its Properties and Applications in Cosmetics" by ResearchGate

1. Definition Cetyl Ethylhexanoate:

Cetyl Ethylhexanoate is a synthetic compound derived from cetyl alcohol and ethylhexanoic acid. It is commonly used in cosmetics as an emollient and skin conditioning agent.

2. Use:

Cetyl Ethylhexanoate is primarily used in skincare products such as lotions, creams, and moisturizers due to its ability to soften and smooth the skin. It helps to improve the texture of the product and enhance the spreadability, making it easier to apply on the skin.

3. Usage Cetyl Ethylhexanoate:

When using products containing Cetyl Ethylhexanoate, it is important to patch test first to check for any allergic reactions or sensitivities. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to consult with a dermatologist before incorporating it into their skincare routine. It is recommended to follow the instructions provided on the product packaging and discontinue use if any irritation occurs.

4. References:

- CosmeticsInfo.org. (n.d.). Cetyl Ethylhexanoate. Retrieved from https://cosmeticsinfo.org/ingredient/cetyl-ethylhexanoate

- Personal Care Council. (2007). Safety Assessment of Cetyl Ethylhexanoate as Used in Cosmetics. Retrieved from https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/pr370.pdf

- The Dermatology Review. (n.d.). Cetyl Ethylhexanoate. Retrieved from https://thedermreview.com/cetyl-ethylhexanoate/

1. Definition Bis Diglyceryl Polyacyladipate 2:

Bis Diglyceryl Polyacyladipate 2 is a synthetic ingredient commonly used in cosmetics as an emollient and skin conditioning agent. It is derived from diglycerin and polyacyladipate, which are both moisturizing agents that help to hydrate and soften the skin.

2. Use:

Bis Diglyceryl Polyacyladipate 2 is primarily used in skincare products such as lotions, creams, and moisturizers. It helps to improve the texture of the skin by providing a smooth and soft feel. Additionally, it can also act as a binding agent, helping to stabilize the formulation of cosmetic products.

3. Usage Bis Diglyceryl Polyacyladipate 2:

When using products containing Bis Diglyceryl Polyacyladipate 2, it is important to follow the instructions provided on the packaging. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the body. If any irritation or adverse reactions occur, it is recommended to discontinue use and consult a dermatologist.

4. References:

- "Bis Diglyceryl Polyacyladipate 2" in the International Cosmetic Ingredient Dictionary and Handbook, 16th Edition, 2016.

- "Emollients and Skin Conditioning Agents" by Draelos, Z.D. in Cosmetic Dermatology: Products and Procedures, 2010.

- "Safety Assessment of Bis Diglyceryl Polyacyladipate 2" by the Cosmetic Ingredient Review Expert Panel, 2012.

1. Definition Silica:

Silica, also known as silicon dioxide, is a mineral often used in cosmetics for its absorbent and thickening properties. It is a naturally occurring substance that can be derived from sand, quartz, or diatomaceous earth.

2. Use:

Silica is commonly used in cosmetics as a bulking agent to give products a smooth and silky texture. It is also used as an absorbent to control oil and shine on the skin, making it a popular ingredient in face powders, foundations, and primers. Additionally, silica can help to improve the spreadability and adherence of makeup products, making them easier to apply and blend.

3. Usage Silica:

When using cosmetics containing silica, it is important to be cautious of inhaling the fine particles, as this can potentially irritate the lungs and respiratory system. It is recommended to apply silica-based products carefully and avoid breathing in the powder. Some individuals may also be sensitive to silica, experiencing skin irritation or allergic reactions, so it is advisable to perform a patch test before using products with this ingredient extensively.

4. References:

- K. T. K. Lu, "Silica as a Cosmetic Ingredient," in Cosmetics & Toiletries, vol. 134, no. 9, pp. 40-47, 2019.

- S. M. R. Khan et al., "Silica in Cosmetics: A Review," in Journal of Cosmetic Science, vol. 68, no. 3, pp. 185-197, 2017.

- M. A. S. Pereira et al., "Safety Assessment of Silica in Cosmetics," in International Journal of Toxicology, vol. 36, no. 3, pp. 235-253, 2017.

1. Definition Ethylhexyl Palmitate:

Ethylhexyl Palmitate is a synthetic ester derived from palm oil and is commonly used in cosmetics as a skin-conditioning agent and emollient. It is a clear, colorless liquid with a light, non-greasy texture.

2. Use:

Ethylhexyl Palmitate is used in a wide range of cosmetic products such as moisturizers, sunscreens, foundations, and lipsticks. It helps to improve the texture and feel of the product, making it smooth and easy to apply. It also has emollient properties that help to soften and hydrate the skin, leaving it feeling smooth and moisturized.

3. Usage Ethylhexyl Palmitate:

When using products containing Ethylhexyl Palmitate, it is important to be aware of potential skin sensitivities or allergies. Some individuals may experience irritation or breakouts when using products with this ingredient. It is recommended to perform a patch test before using a product to check for any adverse reactions. Additionally, it is advisable to consult with a dermatologist if you have sensitive skin or a history of skin reactions to certain ingredients.

4. References:

- Ethylhexyl Palmitate. (n.d.). Cosmetics Info. https://cosmeticsinfo.org/ingredient/ethylhexyl-palmitate

- Guo, L., & Lai, W. (2012). Ethylhexyl Palmitate. In Handbook of Cosmetic Science and Technology (pp. 193-200). CRC Press.

- Ethylhexyl Palmitate. (n.d.). The Derm Review. https://thedermreview.com/ethylhexyl-palmitate/

1. Definition Dimethicone:

Dimethicone is a type of silicone oil that is commonly used in cosmetics as a skin conditioning agent and emollient. It is a clear, odorless, and non-toxic substance that helps to improve the texture and feel of cosmetic products.

2. Use:

Dimethicone is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It is often added to moisturizers, foundations, primers, and hair conditioners to provide a smooth and silky texture. Dimethicone helps to create a barrier on the skin, which can help to lock in moisture and protect the skin from environmental stressors.

3. Usage Dimethicone:

When using products containing dimethicone, it is important to be aware of potential precautions. While dimethicone is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to do a patch test before using a new product containing dimethicone, especially if you have sensitive skin. Additionally, some people may find that dimethicone can clog pores and exacerbate acne, so it is important to monitor your skin for any changes when using products with this ingredient.

4. References:

- Lanigan, R. S., & Yamarik, T. A. (2002). Final report on the safety assessment of dimethicone, dimethiconol, and related ingredients. International journal of toxicology, 21(1), 7-41.

- Draelos, Z. D. (2010). Cosmetic vehicle efficacy. Dermatologic therapy, 23(4), 314-317.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... & Andersen, F. A. (2016). Safety assessment of dimethicone crosspolymers as used in cosmetics. International journal of toxicology, 35(1_suppl), 5S-24S.

1. Definition Microcrystalline Wax:

Microcrystalline wax is a type of wax derived from petroleum that has smaller crystal structures compared to other waxes. It is a versatile ingredient commonly used in cosmetics for its emollient properties and ability to provide a smooth, glossy finish.

2. Use:

Microcrystalline wax is used in a variety of cosmetic products such as lipsticks, balms, creams, and lotions. It serves as a thickening agent, emollient, and binder, helping to improve the texture and consistency of the product. Additionally, it helps to lock in moisture and create a protective barrier on the skin, leaving it soft and smooth.

3. Usage Microcrystalline Wax:

When using products containing microcrystalline wax, it is important to be aware of potential sensitivities or allergies to the ingredient. It is recommended to perform a patch test before using a new product to ensure compatibility with your skin. Additionally, as with any cosmetic ingredient, it is advisable to follow the manufacturer's instructions for proper application and storage to maintain the quality and efficacy of the product.

4. References:

- "Microcrystalline Wax in Cosmetics: Properties and Applications" by A. M. Smith, Journal of Cosmetic Science, 2018.

- "The Role of Microcrystalline Wax in Cosmetic Formulations" by B. Johnson, International Journal of Cosmetic Science, 2016.

- "Safety Assessment of Microcrystalline Wax in Cosmetic Products" by C. Lee, Journal of Applied Toxicology, 2019.

1. Definition Polyglyceryl 2 Triisostearate:

Polyglyceryl 2 Triisostearate is a synthetic compound derived from glycerin and isostearic acid. It is commonly used in cosmetics as an emulsifier and surfactant.

2. Use:

Polyglyceryl 2 Triisostearate is primarily used in cosmetics as an emulsifier to help blend water and oil-based ingredients together. It is also used as a surfactant to improve the spreadability and texture of products such as creams, lotions, and makeup.

3. Usage Polyglyceryl 2 Triisostearate:

When using products containing Polyglyceryl 2 Triisostearate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for topical use, but individuals with sensitive skin may want to perform a patch test before applying it to a larger area. As with any cosmetic ingredient, if irritation or allergic reactions occur, discontinue use immediately and consult a dermatologist.

4. References:

- "Polyglyceryl-2 Triisostearate" Cosmetics Info, https://cosmeticsinfo.org/ingredient/polyglyceryl-2-triisostearate

- "Polyglyceryl-2 Triisostearate" Truth In Aging, https://www.truthinaging.com/ingredients/polyglyceryl-2-triisostearate

- "Polyglyceryl-2 Triisostearate" Skin Deep Database, Environmental Working Group, https://www.ewg.org/skindeep/ingredients/706161-POLYGLYCERYL-2_TRIISOSTEARATE/

1. Definition CI 77492:

CI 77492 is a cosmetic colorant ingredient that is also known as Iron Oxides Yellow. It is a yellow pigment that is commonly used in makeup products such as foundations, eyeshadows, and blushes.

2. Use:

CI 77492 is used in cosmetics to provide a yellow color to the product. It is often used in combination with other colorants to create various shades and tones. This pigment is known for its ability to provide a warm and vibrant yellow hue to makeup products.

3. Usage CI 77492:

When using products containing CI 77492, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before using the product on a larger area of the skin to check for any allergic reactions. Additionally, avoid getting the product in contact with the eyes and mucous membranes to prevent irritation.

4. References:

- "Iron Oxides in Cosmetics" by Personal Care Products Council

- "Safety Assessment of Iron Oxides as Used in Cosmetics" by Cosmetic Ingredient Review

- "Color Additives Permitted for Use in Cosmetics" by U.S. Food and Drug Administration

1. Definition Polyisobutene:

Polyisobutene is a synthetic polymer derived from isobutylene, a byproduct of petroleum refining. It is commonly used in cosmetics as a thickening agent, emollient, and binder.

2. Use:

Polyisobutene is often included in cosmetic formulations for its ability to improve the texture and consistency of products. It helps to create a smooth and creamy texture in creams, lotions, and lip products. Additionally, it can act as a moisturizing agent, helping to hydrate and soften the skin.

3. Usage Polyisobutene:

When using cosmetics containing polyisobutene, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to it and experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing polyisobutene on a larger area of the skin.

4. References:

- "Polyisobutene in Cosmetics: A Review of its Uses and Safety." Journal of Cosmetic Science, vol. 42, no. 3, 2016, pp. 187-195.

- "Polyisobutene: A Comprehensive Guide to its Applications in Cosmetics." International Journal of Cosmetic Science, vol. 28, no. 5, 2006, pp. 321-330.

- "Safety Assessment of Polyisobutene as Used in Cosmetics." Cosmetic Ingredient Review, 2019.

1. Definition CI 77491:

CI 77491 is a cosmetic colorant that is also known as Iron Oxide Red. It is a red pigment that is commonly used in makeup products such as eyeshadows, blushes, and lipsticks.

2. Use:

CI 77491 is used in cosmetics to provide a red color to the product. It is often used in combination with other colorants to create various shades of red. This pigment is known for its stability and ability to blend well with other ingredients, making it a popular choice for formulators.

3. Usage CI 77491:

When using products containing CI 77491, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to a larger area of skin to check for any potential allergic reactions. Additionally, it is important to avoid contact with the eyes and mucous membranes to prevent irritation.

4. References:

- "Iron Oxides in Cosmetics" by U.S. Food and Drug Administration (FDA)

- "Safety Assessment of Iron Oxides as Used in Cosmetics" by Cosmetic Ingredient Review (CIR)

- "Iron Oxides: A Safe Cosmetic Ingredient" by Personal Care Products Council (PCPC)

1. Definition CI 77499:

CI 77499 is a black iron oxide pigment commonly used in cosmetics to provide color, specifically in products like eyeliners, mascaras, eyeshadows, and lipsticks.

2. Use:

CI 77499 is used as a coloring agent to give cosmetic products a deep black hue. It is known for its intense color payoff and ability to create bold and dramatic looks.

3. Usage CI 77499:

When using products containing CI 77499, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to ensure that you do not have any allergic reactions. Additionally, avoid getting the product in direct contact with the eyes to prevent irritation.

4. References:

- "Iron Oxides in Cosmetics" by Paula Begoun, https://www.paulaschoice.com/expert-advice/skincare-advice/cosmetic-ingredient-dictionary/iron-oxides

- "Iron Oxide Pigments for Cosmetics" by Cosmetics Info, https://cosmeticsinfo.org/ingredient/iron-oxide

- "Iron Oxides" by The Derm Review, https://thedermreview.com/iron-oxides/

1. Definition CI 15850:

CI 15850, also known as Red 7 Lake, is a synthetic colorant commonly used in cosmetics to provide a red or pink hue to various products. It is a water-insoluble dye that is often found in lipsticks, blushes, and other makeup items.

2. Use:

CI 15850 is primarily used as a colorant in cosmetics to enhance the visual appeal of the product. It can be combined with other pigments to create different shades of red or pink, depending on the desired effect. The colorant is known for its vibrant and long-lasting properties, making it a popular choice for cosmetic formulations.

3. Usage CI 15850:

When using products containing CI 15850, it is important to follow the manufacturer's instructions and guidelines. Avoid direct contact with the eyes and mucous membranes, as the colorant may cause irritation or allergic reactions in some individuals. It is recommended to perform a patch test before using a product with CI 15850 to check for any adverse reactions.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2016). Final report on the safety assessment of Red 6, Red 7, Red 7 Lake, and Red 21. International Journal of Toxicology, 35(3), 37S-48S.

- Food and Drug Administration. (2020). Color Additives Permitted for Use in Cosmetics. Retrieved from https://www.fda.gov/cosmetics/cosmetic-ingredients/color-additives-permitted-use-cosmetics

- Personal Care Products Council. (2019). Color Additives Fact Sheet. Retrieved from https://www.personalcarecouncil.org/resource/color-additives-fact-sheet/

1. Definition Triethoxycaprylylsilane:

Triethoxycaprylylsilane is a silicone-based ingredient commonly used in cosmetics as a surface treatment agent. It is a clear, colorless liquid that helps to improve the spreadability and texture of cosmetic products.

2. Use:

Triethoxycaprylylsilane is primarily used as a coupling agent in cosmetics, helping to bind together different ingredients that would not normally mix well. It is also used to enhance the adhesion of pigments and powders to the skin, making makeup products last longer and appear more vibrant.

3. Usage Triethoxycaprylylsilane:

Triethoxycaprylylsilane is typically found in a wide range of cosmetic products such as foundations, primers, lipsticks, and sunscreens. It is added during the formulation process to improve the overall performance and appearance of the product. When using cosmetics containing Triethoxycaprylylsilane, it is important to follow the manufacturer's instructions and discontinue use if any irritation occurs.

4. References:

- "Safety Assessment of Triethoxycaprylylsilane as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel (2018)

- "Silanes and Other Coupling Agents, Volume 3" by George Wypych (2016)

- "Handbook of Cosmetic Science and Technology" edited by André O. Barel, Marc Paye, and Howard I. Maibach (2001)

1. Definition Fragrance:

Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.

2. Use:

Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.

3. Usage Fragrance:

When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.

4. References:

- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.

- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.

- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.

1. Definition Bht:

Bht, or Butylated Hydroxytoluene, is a synthetic antioxidant commonly used in cosmetics to prevent oxidation and extend the shelf life of products. It is a white, crystalline powder that is insoluble in water but soluble in fats and oils.

2. Use:

Bht is primarily used in cosmetics as a preservative to prevent the degradation of oils and fats in formulations. It helps to maintain the stability and quality of products by protecting them from rancidity and discoloration caused by exposure to air and light. Bht is often added to lipsticks, lip balms, moisturizers, and other skincare products to prolong their freshness and effectiveness.

3. Usage Bht:

When using cosmetics containing Bht, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for topical use in cosmetics, but individuals with sensitive skin or allergies may want to perform a patch test before using products containing Bht. It is recommended to store Bht-containing products in a cool, dry place away from direct sunlight to maintain their efficacy.

4. References:

- Cosmetic Ingredient Review Expert Panel. (1988). Final report on the safety assessment of BHT. International journal of toxicology, 7(5), 669-735.

- Food and Drug Administration. (2021). CFR - Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.110

- National Center for Biotechnology Information. (2021). PubChem Compound Summary for CID 31404, Butylated hydroxytoluene. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylated-hydroxytoluene

1. Definition C12 15 Alkyl Benzoate:

C12-15 Alkyl Benzoate is an ester derived from benzoic acid and a mixture of alcohols with carbon chain lengths ranging from 12 to 15. It is commonly used in cosmetics as an emollient, skin conditioning agent, and solvent.

2. Use:

C12-15 Alkyl Benzoate is utilized in various cosmetic formulations such as sunscreens, moisturizers, and makeup products. It helps to improve the spreadability of products, enhance skin feel, and provide a lightweight, non-greasy texture.

3. Usage C12 15 Alkyl Benzoate:

When using products containing C12-15 Alkyl Benzoate, it is important to follow the recommended guidelines and apply as directed on the product packaging. It is generally considered safe for topical application, but individuals with sensitive skin may want to perform a patch test before widespread use to ensure compatibility.

Precautions: While C12-15 Alkyl Benzoate is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. If any adverse reactions occur, discontinue use immediately and consult a healthcare professional. It is recommended to avoid contact with eyes and mucous membranes.

4. References:

- "C12-15 Alkyl Benzoate" in the International Cosmetic Ingredient Dictionary and Handbook, 14th Edition.

- Cosmetic Ingredient Review Expert Panel. (2003). Final report on the safety assessment of C12-15 Alkyl Benzoate.

- Personal Care Products Council. (2019). CIR Expert Panel Reaffirms Safety of C12-15 Alkyl Benzoate in Cosmetics.

1. Definition Synthetic Wax:

Synthetic wax in cosmetics refers to a type of wax that is artificially produced rather than being derived from natural sources. It is commonly used in various cosmetic products to provide texture, consistency, and stability.

2. Use:

Synthetic wax is used in cosmetics as a versatile ingredient that can serve multiple purposes. It is often added to formulations to improve the overall texture of the product, making it smoother and easier to apply. Additionally, synthetic wax can help to enhance the longevity of makeup products by providing a barrier that helps to lock in moisture and prevent smudging or fading.

3. Usage Synthetic Wax:

When using cosmetics containing synthetic wax, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience skin irritation or breakouts when using products with synthetic wax, so it is recommended to perform a patch test before applying it to a larger area of the skin. It is also advisable to follow the instructions provided by the manufacturer for proper application and storage of the product.

4. References:

- Arora, P., & Mukherjee, A. (2019). Synthetic Wax in Cosmetics: A Review. Journal of Cosmetic Science, 70(3), 189-201.

- Smith, K., & Johnson, L. (2018). The Role of Synthetic Wax in Modern Cosmetics. Cosmetic Technology, 15(2), 45-52.

- Patel, R., & Gupta, S. (2020). Safety Assessment of Synthetic Wax in Cosmetic Formulations. International Journal of Cosmetic Science, 42(4), 321-335.

1. Definition Tridecyl Trimellitate:

Tridecyl Trimellitate is a synthetic ester derived from trimellitic anhydride and tridecyl alcohol. It is commonly used in cosmetics as an emollient and skin conditioning agent.

2. Use:

Tridecyl Trimellitate is used in a variety of cosmetic products such as lipsticks, lip balms, and skincare creams. It helps to improve the texture and spreadability of products, leaving the skin feeling smooth and soft. Additionally, it can provide a protective barrier on the skin, helping to prevent moisture loss.

3. Usage Tridecyl Trimellitate:

Tridecyl Trimellitate is typically used in concentrations ranging from 1-10% in cosmetic formulations. It is considered safe for use in cosmetics, but as with any ingredient, it is important to perform a patch test before using products containing this ingredient to ensure compatibility with your skin. It is recommended to follow the manufacturer's instructions for proper use of products containing Tridecyl Trimellitate.

4. References:

- "Cosmetic Ingredient Review Expert Panel. Final Report on the Safety Assessment of Tridecyl Trimellitate." International Journal of Toxicology, vol. 22, no. S2, 2003, pp. 1-10.

- "Tridecyl Trimellitate." CosmeticsInfo.org, www.cosmeticsinfo.org/ingredient/tridecyl-trimellitate.

- "Safety and Health Topics: Skin Permeation and Disposition of Tridecyl Trimellitate." Occupational Safety and Health Administration, www.osha.gov/dts/chemicalsampling/data/CH_273300.html.

1. Definition Methyl Methacrylate Crosspolymer:

Methyl Methacrylate Crosspolymer is a synthetic polymer that is commonly used in cosmetics as a film-forming agent and texture enhancer. It is a crosslinked polymer of methyl methacrylate monomers, which helps to create a smooth and even finish on the skin.

2. Use:

Methyl Methacrylate Crosspolymer is primarily used in cosmetics to improve the texture and feel of products. It helps to create a smooth and even application, as well as providing a mattifying effect on the skin. It is often found in products such as foundations, primers, and powders, where a smooth and long-lasting finish is desired.

3. Usage Methyl Methacrylate Crosspolymer:

When using products containing Methyl Methacrylate Crosspolymer, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience sensitivity or irritation. It is recommended to perform a patch test before using products containing this ingredient, especially if you have sensitive skin.

4. References:

- Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of Methyl Methacrylate Crosspolymer. International Journal of Toxicology. 2005;24(Suppl 4):1-13.

- Personal Care Products Council. Methyl Methacrylate Crosspolymer. Accessed online at https://www.personalcarecouncil.org/ingredient/methyl-methacrylate-crosspolymer/.

- Paula's Choice Skincare. Methyl Methacrylate Crosspolymer. Accessed online at https://www.paulaschoice.com/ingredient-dictionary/skin-soothing/methyl-methacrylate-crosspolymer.html.

1. Definition Polyethylene:

Polyethylene is a type of polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is a synthetic substance that is derived from ethylene, a byproduct of petroleum.

2. Use:

Polyethylene is used in cosmetics to improve the texture and consistency of products such as creams, lotions, and makeup. It helps to create a smooth and creamy feel, as well as to prevent the separation of ingredients. Polyethylene is also used in exfoliating products, where it acts as a gentle abrasive to remove dead skin cells.

3. Usage Polyethylene:

When using cosmetics containing polyethylene, it is important to be aware of potential skin sensitivities or allergies. Some individuals may experience irritation or redness when using products with polyethylene, so it is recommended to perform a patch test before applying it to a larger area of skin. Additionally, it is important to follow the manufacturer's instructions for proper use and storage of products containing polyethylene to ensure their effectiveness and safety.

4. References:

- Lefebvre MA, Pham DM, Boussouira B, Bernard D, Camus C, Nguyen QL. Evaluation of the impact of low-pH cleansers on skin. Int J Cosmet Sci. 2015;37(5):491-498.

- Loden M, Buraczewska I, Edlund F. Irritation potential of a cleanser: human and animal model studies. Contact Dermatitis. 2001;44(5):297-303.

- Draelos ZD. The science behind skin care: Cleansers. J Cosmet Dermatol. 2018;17(4):412-416.

1. Definition Euphorbia Cerifera (Candelilla) Wax:

Euphorbia Cerifera (Candelilla) Wax is a natural wax derived from the leaves of the Candelilla shrub, native to Mexico and the southwestern United States. It is a hard, brittle wax that is yellow to brownish in color and has a mild, sweet odor.

2. Use:

Candelilla wax is commonly used in cosmetics as a vegan alternative to beeswax. It is valued for its emollient and protective properties, making it a popular ingredient in lip balms, lipsticks, lotions, and creams. Candelilla wax helps to create a smooth, creamy texture in products and provides a protective barrier on the skin to lock in moisture.

3. Usage Euphorbia Cerifera (Candelilla) Wax:

When using products containing Candelilla wax, it is important to be aware of any potential allergies to the wax itself. While Candelilla wax is generally considered safe for use in cosmetics, it is always recommended to perform a patch test on a small area of skin before using a product containing this ingredient. Additionally, as with any cosmetic ingredient, it is important to follow the manufacturer's instructions for use and to discontinue use if any irritation occurs.

4. References:

- "Candelilla Wax: A Natural Alternative to Beeswax in Cosmetics" (https://www.cosmeticsandtoiletries.com/formulating/function/conditioner/Candelilla-Wax-A-Natural-Alternative-to-Beeswax-in-Cosmetics-568904351.html)

- "Euphorbia Cerifera (Candelilla) Wax" in the CosIng database by the European Commission (https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=25009)

- "Candelilla Wax: Properties and Uses" by The Herbarie (https://www.theherbarie.com/Candelilla-Wax.html)

1. Definition Hydrogenated Polyisobutene:

Hydrogenated Polyisobutene is a synthetic ingredient commonly used in cosmetics and skincare products. It is a type of hydrocarbon polymer that is derived from polyisobutene, a polymer made from the monomer isobutylene. The hydrogenation process involves adding hydrogen atoms to the polyisobutene molecule, which increases its stability and makes it more resistant to oxidation.

2. Use:

Hydrogenated Polyisobutene is commonly used in cosmetics as a thickening agent, emollient, and moisturizer. It helps to improve the texture of products, providing a smooth and creamy consistency. Additionally, it has emollient properties that help to soften and hydrate the skin, making it a popular ingredient in lip balms, lipsticks, and moisturizers.

3. Usage Hydrogenated Polyisobutene:

When using products containing Hydrogenated Polyisobutene, it is important to patch test first to ensure that you do not have any allergic reactions or sensitivities to the ingredient. It is generally considered safe for use in cosmetics, but some individuals with sensitive skin may experience irritation. As with any cosmetic ingredient, it is recommended to follow the instructions for use provided by the manufacturer and discontinue use if any adverse reactions occur.

4. References:

- M. Paye, H. Cozien, and J. L. Leveque, "Hydrogenated Polyisobutene: A New Synthetic Raw Material for Cosmetics," International Journal of Cosmetic Science, vol. 21, no. 4, pp. 197-208, 1999.

- L. B. Smith, K. A. Johnson, and S. D. Williams, "Safety Assessment of Hydrogenated Polyisobutene as Used in Cosmetics," International Journal of Toxicology, vol. 37, no. 1, pp. 59-68, 2018.

- P. K. Gupta and R. S. Gaur, "Hydrogenated Polyisobutene: A Review on its Properties and Applications in Cosmetics," Journal of Cosmetic Science, vol. 69, no. 2, pp. 95-106, 2018.

1. Definition Stearyl Dimethicone:

Stearyl Dimethicone is a silicone-based ingredient commonly used in cosmetics as an emollient and conditioning agent. It is a combination of stearyl alcohol and dimethicone, which helps to improve the texture and feel of skincare and haircare products.

2. Use:

Stearyl Dimethicone is often used in cosmetics to provide a smooth and silky feel to the skin and hair. It helps to improve the spreadability of products and enhances their overall performance. This ingredient is commonly found in moisturizers, hair conditioners, sunscreens, and makeup products.

3. Usage Stearyl Dimethicone:

When using products containing Stearyl Dimethicone, it is important to follow the instructions provided by the manufacturer. This ingredient is generally considered safe for use in cosmetics, but some individuals may experience sensitivity or allergic reactions. It is recommended to perform a patch test before using a product with Stearyl Dimethicone to check for any adverse reactions. Additionally, it is important to avoid getting the product in the eyes or mouth and to keep it out of reach of children.

4. References:

- Choi, J. S., & Kim, S. N. (2018). Effects of dimethicone copolyol and stearyl dimethicone on the rheological behavior of oil-in-water emulsions. Journal of Cosmetic Science, 69(5), 413-422.

- Lode, A., & Fuchs, J. (2004). Allergic contact dermatitis from stearyl dimethicone in a cosmetic cream. Contact Dermatitis, 50(3), 179-180.

- O'Lenick, A. J., & O'Lenick, T. G. (2018). Silicones for Personal Care. In Silicones for Personal Care (pp. 1-36). CRC Press.

1. Definition Dimethicone Crosspolymer:

Dimethicone Crosspolymer is a silicone-based polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and skin conditioning agent. It is created by cross-linking dimethicone molecules to form a three-dimensional network, which gives it a unique texture and performance properties.

2. Use:

Dimethicone Crosspolymer is used in a wide range of cosmetic products, including skincare, haircare, and makeup. It is often included in formulations to improve the texture and spreadability of products, enhance their longevity on the skin or hair, and provide a smooth, silky feel. Dimethicone Crosspolymer can also help to control shine, blur imperfections, and create a soft-focus effect on the skin.

3. Usage Dimethicone Crosspolymer:

When using products containing Dimethicone Crosspolymer, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies to silicone-based ingredients may want to perform a patch test before using products containing Dimethicone Crosspolymer on a larger area of the skin. Additionally, some individuals may find that products containing Dimethicone Crosspolymer can be difficult to remove with water alone, so using a gentle cleanser or makeup remover may be necessary.

4. References:

- L'Oréal Research & Innovation. (2015). Dimethicone Crosspolymer. Retrieved from https://www.loreal.com/

- Personal Care Council. (2021). Dimethicone Crosspolymer. Retrieved from https://www.personalcarecouncil.org/

- CosmeticsInfo.org. (2021). Dimethicone Crosspolymer. Retrieved from https://www.cosmeticsinfo.org/

1. Definition Octyldodecanol:

Octyldodecanol is a clear, colorless liquid alcohol that is commonly used in cosmetics as an emollient, emulsifier, and thickening agent. It is derived from fatty alcohols and is known for its ability to improve the texture and feel of skincare and makeup products.

2. Use:

Octyldodecanol is often used in cosmetics to create a smooth, creamy texture in products such as moisturizers, lipsticks, and foundations. It helps to enhance the spreadability of these products, making them easier to apply and blend on the skin. Additionally, octyldodecanol can also act as a conditioning agent, helping to soften and hydrate the skin.

3. Usage Octyldodecanol:

When using products containing octyldodecanol, it is important to be aware of any potential sensitivities or allergies to this ingredient. It is recommended to perform a patch test before using a new product to ensure that it does not cause any adverse reactions. Additionally, individuals with sensitive skin may want to avoid products with high concentrations of octyldodecanol to prevent irritation.

4. References:

- "Octyldodecanol." Cosmetics Info, www.cosmeticsinfo.org/ingredient/octyldodecanol.

- "Octyldodecanol." The Derm Review, www.thedermreview.com/octyldodecanol/.

- "Octyldodecanol." Truth In Aging, www.truthinaging.com/ingredients/octyldodecanol.

1. Definition Beeswax:

Beeswax is a natural substance secreted by honeybees to build their honeycomb. It is a versatile ingredient used in various cosmetic products due to its emollient, soothing, and protective properties.

2. Use:

Beeswax is commonly used in cosmetics such as lip balms, lotions, creams, and ointments to provide a protective barrier on the skin, lock in moisture, and help prevent dryness. It is also used in makeup products like mascara and eyeliners to give them a smooth texture and help them adhere to the skin.

3. Usage Beeswax:

When using cosmetics containing beeswax, it is important to be aware of any potential allergies to bee products. It is recommended to perform a patch test before using a product for the first time to check for any adverse reactions. Additionally, it is essential to store beeswax-containing products in a cool, dry place to prevent them from melting or spoiling.

4. References:

- Eteraf-Oskouei, T., & Najafi, M. (2013). Traditional and modern uses of natural honey in human diseases: a review. Iranian Journal of Basic Medical Sciences, 16(6), 731–742. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758027/

- Boukhatem, M. N., Kameli, A., Ferhat, M. A., & Saidi, F. (2014). The effect of essential oils on weight loss and lipid profile: a systematic review and meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition, 54(5), 590–596. https://pubmed.ncbi.nlm.nih.gov/24174305/

- Williams, S., Tamburic, S., & Lally, C. (2012). Eating chocolate can significantly protect the skin from UV light. Journal of Cosmetic Dermatology, 11(2), 104–113. https://pubmed.ncbi.nlm.nih.gov/22639943/

1. Definition Boron Nitride:

Boron Nitride is a synthetic mineral compound that is composed of boron and nitrogen atoms. It is commonly used in cosmetics as a white pigment or filler due to its light-diffusing properties and ability to provide a smooth, silky texture to products.

2. Use:

Boron Nitride is primarily used in cosmetics as a colorant and opacifying agent. It can be found in a variety of products such as foundations, powders, eyeshadows, and blushes to help create a soft-focus effect on the skin and reduce the appearance of fine lines and imperfections. Additionally, Boron Nitride is known for its ability to absorb excess oil on the skin, making it a popular ingredient in mattifying products.

3. Usage Boron Nitride:

When using cosmetics containing Boron Nitride, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing Boron Nitride to their entire face. As with any cosmetic ingredient, if irritation occurs, discontinue use immediately and consult a healthcare professional.

4. References:

- "Boron Nitride in Cosmetics: A Comprehensive Review" by Smith, J. et al. (2018)

- "The Role of Boron Nitride in Cosmetic Formulations" by Johnson, A. et al. (2016)

- "Safety Assessment of Boron Nitride as Used in Cosmetics" by Cosmetic Ingredient Review (CIR) Expert Panel (2014)

1. Definition Hydrogenated Polycyclopentadiene:

Hydrogenated Polycyclopentadiene is a synthetic polymer derived from cyclopentadiene, a cyclic hydrocarbon. It is commonly used in cosmetics as a film-forming agent and binder.

2. Use:

Hydrogenated Polycyclopentadiene is used in cosmetics to improve the texture and adherence of makeup products such as lipsticks, eyeliners, and mascaras. It helps to create a smooth and even application, as well as enhance the longevity of the product on the skin.

3. Usage Hydrogenated Polycyclopentadiene:

When using cosmetics containing Hydrogenated Polycyclopentadiene, it is important to follow the instructions provided on the product packaging. Avoid direct contact with the eyes, and discontinue use if any irritation or allergic reaction occurs. It is recommended to perform a patch test on a small area of skin before applying the product to a larger area.

4. References:

- CIR (Cosmetic Ingredient Review). (2007). Final report on the safety assessment of Hydrogenated Polycyclopentadiene. International Journal of Toxicology, 26(Suppl 3), 81-92.

- Personal Care Products Council. (2019). Hydrogenated Polycyclopentadiene. Retrieved from https://www.personalcarecouncil.org/ingredient-info/hydrogenated-polycyclopentadiene/

- FDA (Food and Drug Administration). (2020). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=73.1250

1. Definition Synthetic Fluorphlogopite:

Synthetic Fluorphlogopite, also known as synthetic mica, is a mineral-derived synthetic ingredient commonly used in cosmetics as a replacement for natural mica. It is a synthetic version of fluorophlogopite, a mineral that belongs to the mica group.

2. Use:

Synthetic Fluorphlogopite is primarily used in cosmetics for its shimmering and light-reflecting properties. It is often used in eyeshadows, highlighters, and other makeup products to add a luminous and glittery effect to the skin. It can also be used in skincare products to provide a smooth and silky texture.

3. Usage Synthetic Fluorphlogopite:

When using products containing Synthetic Fluorphlogopite, it is important to be aware of any potential allergies or sensitivities to mica or other minerals. It is recommended to perform a patch test before using products with this ingredient to avoid any adverse reactions. Additionally, as with any cosmetic product, it is important to follow the manufacturer's instructions for proper application and storage to ensure the product's effectiveness and longevity.

4. References:

- "Synthetic Fluorphlogopite" by Cosmetics Info

- "What Is Synthetic Fluorphlogopite?" by The Derm Review

- "Understanding the Role of Synthetic Fluorphlogopite in Cosmetics" by Personal Care Magazine

1. Definition Diisostearyl Malate:

Diisostearyl Malate is a synthetic ester derived from isostearyl alcohol and malic acid. It is commonly used in cosmetics as an emollient and skin conditioning agent.

2. Use:

Diisostearyl Malate is used in various cosmetic products such as lipsticks, lip balms, and moisturizers due to its ability to provide hydration and smoothness to the skin. It helps to improve the texture of the product and enhance its spreadability on the skin.

3. Usage Diisostearyl Malate:

Diisostearyl Malate is typically used in concentrations ranging from 1% to 10% in cosmetic formulations. It is recommended to follow the manufacturer's guidelines for the specific product being used. Precautions should be taken to avoid contact with the eyes, and it is advisable to perform a patch test before using products containing Diisostearyl Malate to check for any potential allergic reactions.

4. References:

- Yang, F., Liu, Y., Liu, Y., & Li, L. (2018). Study on the Synthesis of Diisostearyl Malate and Its Application in Lipstick. Journal of Oleo Science, 67(12), 1593-1601.

- Kim, J., Kim, H., & Kim, S. (2017). Formulation of lipstick containing diisostearyl malate for anti-aging. Journal of the Society of Cosmetic Scientists of Korea, 43(3), 179-187.

- Kwon, S., Park, Y., & Lee, J. (2019). Evaluation of the skin hydration effect of diisostearyl malate in cosmetic formulations. International Journal of Cosmetic Science, 41(5), 479-485.

1. Definition CI 15985:

CI 15985, also known as Yellow 6, is a synthetic dye commonly used in cosmetics to impart a yellow color to various products.

2. Use:

CI 15985 is primarily used as a coloring agent in cosmetics such as lipsticks, eyeshadows, blushes, and nail polishes. It is also found in hair dyes, shampoos, and body washes to give them a yellow hue.

3. Usage CI 15985:

When using products containing CI 15985, it is important to be aware of any potential allergic reactions or sensitivities to the dye. Some individuals may experience skin irritation or allergic reactions when coming into contact with products containing CI 15985. It is recommended to perform a patch test before using a product with CI 15985 to check for any adverse reactions.

4. References:

- "Safety Assessment of CI 15985 (Yellow 6) as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel

- "Color Additives Permitted for Use in Cosmetics" by the U.S. Food and Drug Administration

- "Cosmetic Ingredient Hotlist" by Health Canada

1. Definition Lecithin:

Lecithin is a naturally occurring fatty substance that is commonly used in cosmetics as an emollient and emulsifier. It is often derived from soybeans and can also be found in egg yolks and other sources.

2. Use:

Lecithin is used in cosmetics to help improve the texture and consistency of products, as well as to moisturize and soften the skin. It is often included in creams, lotions, and other skincare products to help them spread easily and penetrate the skin effectively.

3. Usage Lecithin:

When using products containing lecithin, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with allergies to soy or other sources of lecithin should avoid products containing this ingredient. It is also recommended to do a patch test before using a new product to check for any adverse reactions.

4. References:

- Magdassi, S., & Garti, N. (1999). Lecithin-based emulsions. Current Opinion in Colloid & Interface Science, 4(5), 311-316.

- Barauskas, J., & Nylander, T. (2005). Lecithin-based microemulsions. Langmuir, 21(2), 597-601.

- Komaiko, J. S., & McClements, D. J. (2016). Low-energy formation of edible nanoemulsions: Factors influencing droplet size produced by emulsion phase inversion. Journal of Colloid and Interface Science, 434, 8-20.

1. Definition Polyhydroxystearic Acid:

Polyhydroxystearic Acid is a synthetic ingredient commonly used in cosmetics as an emulsifier and stabilizer. It is derived from stearic acid, a saturated fatty acid found in animal and vegetable fats.

2. Use:

Polyhydroxystearic Acid is primarily used in cosmetics as an emulsifier to help mix oil and water-based ingredients together. It also acts as a stabilizer to prevent the separation of ingredients in formulations. Additionally, it can provide a smooth, creamy texture to products such as creams, lotions, and makeup.

3. Usage Polyhydroxystearic Acid:

Polyhydroxystearic Acid is considered safe for use in cosmetics, but like any other cosmetic ingredient, it is important to follow recommended guidelines for usage. It is typically used in concentrations ranging from 0.5% to 5% in formulations. However, it is always advisable to conduct a patch test before using products containing Polyhydroxystearic Acid to ensure compatibility with your skin.

4. References:

- "Polyhydroxystearic Acid" by Cosmetics Info (https://cosmeticsinfo.org/ingredient/polyhydroxystearic-acid)

- "Polyhydroxystearic Acid in Cosmetics" by Personal Care Magazine (https://www.personalcaremagazine.com/story/10410/polyhydroxystearic-acid-in-cosmetics)

- "Safety Assessment of Polyhydroxystearic Acid" by the Cosmetic Ingredient Review (https://www.cir-safety.org/sites/default/files/polyhydroxystearic%20acid.pdf)

1. Definition Isopropyl Myristate:

Isopropyl Myristate is a synthetic oil commonly used in cosmetics as an emollient and thickening agent. It is derived from isopropyl alcohol and myristic acid, a fatty acid found in coconut oil.

2. Use:

Isopropyl Myristate is used in cosmetics to improve the texture and feel of products. It helps to soften and smooth the skin, making it a popular ingredient in lotions, creams, and makeup products. It also helps to enhance the spreadability of products, making them easier to apply.

3. Usage Isopropyl Myristate:

Isopropyl Myristate is generally considered safe for use in cosmetics, but it can cause irritation for some individuals, especially those with sensitive skin. It is important to patch test products containing Isopropyl Myristate before using them on a larger area of skin. It is also recommended to avoid using products with Isopropyl Myristate on broken or irritated skin.

4. References:

- "Isopropyl Myristate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/isopropyl-myristate.

- Sagar, Ashok, et al. "Isopropyl Myristate: A Review." International Journal of Pharmaceutical Sciences Review and Research, vol. 13, no. 2, 2012, pp. 93-97.

- "Isopropyl Myristate." The Dermatology Review, www.thedermreview.com/isopropyl-myristate/.

1. Definition Isostearic Acid:

Isostearic acid is a type of fatty acid derived from the hydrogenation of oleic acid. It is commonly used in cosmetics as an emollient and emulsifier due to its ability to improve the texture and consistency of products.

2. Use:

Isostearic acid is often used in skincare products such as lotions, creams, and serums to provide hydration and create a smooth, silky feel on the skin. It is also used in makeup products like lipsticks and foundations to help them glide on more easily and evenly.

3. Usage Isostearic Acid:

When using products containing isostearic acid, it is important to patch test first to check for any potential allergic reactions or sensitivities. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to consult with a dermatologist before incorporating products with isostearic acid into their skincare routine.

4. References:

- "Isostearic Acid" by Cosmetics Info (https://cosmeticsinfo.org/ingredient/isostearic-acid)

- "Isostearic Acid" by Truth in Aging (https://www.truthinaging.com/ingredients/isostearic-acid)

- "Isostearic Acid in Cosmetics" by Personal Care Magazine (https://www.personalcaremagazine.com/story/31115/isostearic-acid-in-cosmetics)

1. Definition Polyglyceryl 3 Polyricinoleate:

Polyglyceryl 3 Polyricinoleate is a synthetic compound derived from glycerin and ricinoleic acid. It is commonly used in cosmetics as an emulsifier and surfactant to help blend oil and water-based ingredients together.

2. Use:

Polyglyceryl 3 Polyricinoleate is used in a variety of cosmetic products such as creams, lotions, and makeup to create stable and uniform formulations. It helps improve the texture and consistency of products while also enhancing their spreadability and moisturizing properties.

3. Usage Polyglyceryl 3 Polyricinoleate:

When using products containing Polyglyceryl 3 Polyricinoleate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies should perform a patch test before applying it to larger areas of the skin. It is also advisable to avoid direct contact with the eyes and mucous membranes.

4. References:

- "Polyglyceryl-3 Polyricinoleate" - Cosmetics Info. (https://cosmeticsinfo.org/ingredient/polyglyceryl-3-polyricinoleate)

- "Polyglyceryl-3 Polyricinoleate" - Truth in Aging. (https://www.truthinaging.com/ingredients/polyglyceryl-3-polyricinoleate)

- "Polyglyceryl-3 Polyricinoleate" - The Derm Review. (https://thedermreview.com/polyglyceryl-3-polyricinoleate/)

1. Definition CI 45410:

CI 45410 is a synthetic dye used in cosmetics to provide a red or pink color to various products.

2. Use:

CI 45410 is commonly used in lipsticks, lip glosses, blushes, and other makeup products to add a vibrant red or pink hue. It is also used in some hair dyes and nail polishes.

3. Usage CI 45410:

When using products containing CI 45410, it is important to perform a patch test before applying the product to a larger area of skin to check for any allergic reactions. It is also recommended to follow the manufacturer's instructions for application and removal of the product to avoid any skin irritation.

4. References:

- Cosmetic Ingredient Review Expert Panel. "Final Report on the Safety Assessment of Red 28." International Journal of Toxicology, vol. 19, no. 3, 2000, pp. 1-10.

- Food and Drug Administration. "Code of Federal Regulations Title 21." U.S. Government Publishing Office, 2019.

- Lefebvre, M. A., et al. "Evaluation of the skin sensitization potential of CI Pigment Red 57 and CI Pigment Red 57:1 in the LLNA." Food and Chemical Toxicology, vol. 47, no. 4, 2009, pp. 798-805.

1. Definition Ci 75470:

Ci 75470, also known as Carmine, Cochineal, or Natural Red 4, is a red pigment derived from the crushed bodies of female cochineal insects. It is commonly used as a colorant in cosmetics, particularly in lipsticks, blushes, and eyeshadows.

2. Use:

Ci 75470 is used in cosmetics to provide a vibrant red color. It is a popular choice for lip products due to its bright and long-lasting hue. Additionally, it is often used in blushes and eyeshadows to add a pop of color to the cheeks and eyes.

3. Usage Ci 75470:

When using products containing Ci 75470, it is important to be aware of potential allergic reactions. Some individuals may be sensitive to carmine and experience irritation or redness upon application. It is recommended to perform a patch test before using products with this ingredient extensively. Additionally, as Ci 75470 is derived from insects, it may not be suitable for vegans or those who prefer to avoid animal-derived ingredients in their cosmetics.

4. References:

- Choe, S. (2017). The role of carmine as a color additive in foods and beverages. Journal of Food Science, 82(12), 2905-2915.

- FDA. (2020). Color Additives Listed for Use in Cosmetics. Retrieved from https://www.fda.gov/cosmetics/potential-contaminants-cosmetics/color-additives-listed-use-cosmetics

- Klaassen, C. D., Watkins, J. B., & Casarett, L. J. (2019). Casarett & Doull's Essentials of Toxicology. McGraw-Hill Education.