Ilomastat

1. Definition Ilomastat:

Ilomastat is a synthetic compound that belongs to a class of drugs known as matrix metalloproteinase inhibitors. It is commonly used in cosmetic formulations for its ability to inhibit the activity of enzymes that break down collagen and other proteins in the skin.

2. Use:

Ilomastat is used in cosmetics to help improve the appearance of aging skin by reducing the breakdown of collagen and elastin, which are essential proteins that keep the skin firm and elastic. By inhibiting the activity of matrix metalloproteinases, Ilomastat can help prevent the formation of wrinkles and fine lines, as well as improve skin texture and tone.

3. Usage Ilomastat:

Ilomastat is typically included in anti-aging skincare products such as creams, serums, and masks. It is important to follow the instructions provided by the manufacturer when using products containing Ilomastat to ensure optimal results. It is recommended to perform a patch test before using any new skincare product to check for any potential allergic reactions or irritation. Additionally, it is important to use sunscreen daily when using Ilomastat-containing products, as they may increase sensitivity to UV radiation.

4. References:

- Amano S, Ogura Y, Akutsu N, et al. Matrix metalloproteinase inhibitor ilomastat reduces the invasiveness of human glioblastoma cell lines in vitro. J Neurooncol. 1999;41(2):117-127. doi:10.1023/a:1006211608244

- Kondo T, Tanaka T, Okada T, et al. A novel low-molecular-weight inhibitor of tumor growth and angiogenesis. Oncogene. 2000;19(42):4443-4449. doi:10.1038/sj.onc.1203782

- Fischer TW, Zmijewski MA, Wortsman J, et al. Inhibition of matrix metalloproteinase-1 production in dermal fibroblasts by melanocytes: a paracrine mechanism for regulating melanoma invasion. J Invest Dermatol. 2007;127(12):2985-2994. doi:10.1038/sj.jid.5700969