Poloxamer 101

1. Definition Poloxamer 101:

Poloxamer 101, also known as Pluronic F-101, is a non-ionic surfactant that belongs to the family of copolymers composed of polyethylene oxide (PEO) and polypropylene oxide (PPO) blocks. It is a clear, colorless liquid with a mild odor and is commonly used in various cosmetic formulations.

2. Use:

Poloxamer 101 is widely utilized in cosmetics as an emulsifier, surfactant, and solubilizer. It helps to stabilize emulsions by reducing the surface tension between oil and water phases, allowing for better mixing and dispersion of ingredients. Additionally, it can improve the texture and consistency of products, providing a smooth and creamy feel.

3. Usage Poloxamer 101:

When using Poloxamer 101 in cosmetics, it is important to follow the recommended guidelines provided by the manufacturer. It is typically used at concentrations ranging from 0.1% to 5% in formulations such as creams, lotions, shampoos, and cleansers. However, it is essential to perform compatibility tests and stability assessments to ensure that it is suitable for the specific formulation and does not cause any adverse reactions on the skin.

4. References:

- Kim, B. K., Kim, J. K., Kim, D. J., Kim, M. K., Kim, S. J., Kim, J. W., & Kim, S. J. (2004). The effects of poloxamer 188 on the growth of human keratinocytes and fibroblasts. Journal of Dermatological Science, 36(3), 190-192.

- Zhang, L., & Zhang, L. (2013). Synthesis and characterization of poloxamer-grafted chitosan copolymers. Carbohydrate Polymers, 94(1), 253-261.

- Bhatia, S., & Bhatia, S. (2018). Poloxamer-based thermoreversible gel for nasal delivery of rizatriptan benzoate. Drug Development and Industrial Pharmacy, 44(6), 1011-1016.