Poloxamer 188

1. Definition Poloxamer 188:

Poloxamer 188, also known as Pluronic F-68, is a non-ionic surfactant that is commonly used in cosmetics for its emulsifying, stabilizing, and solubilizing properties. It is a copolymer composed of polyoxyethylene and polyoxypropylene blocks, which gives it the ability to interact with both water and oil phases in cosmetic formulations.

2. Use:

Poloxamer 188 is often used in cosmetics as an emulsifier to help blend water and oil-based ingredients together. It can also act as a stabilizer, preventing ingredients from separating in the formulation. Additionally, it is used as a solubilizer to improve the solubility of certain ingredients in water-based products.

3. Usage Poloxamer 188:

When using cosmetics containing Poloxamer 188, it is important to follow the recommended usage guidelines provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing this ingredient to their skin. As with any cosmetic ingredient, if any irritation or adverse reaction occurs, discontinue use immediately.

4. References:

- Garg, Tarun, et al. "Poloxamer: A novel functional molecule for drug delivery, diagnostics, and therapy." Current pharmaceutical design 16.19 (2010): 2159-2175.

- Kabanov, Alexander V., and Elena V. Batrakova. "Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier." Advanced drug delivery reviews 55.1 (2003): 151-164.

- Dufes, Christine, et al. "Uptake of palmitoyl, oligoarginine, and pluronics-modified nanoparticles by human stem cells." Pharmaceutical research 25.8 (2008): 1871-1877.