Sphinganine

1. Definition Sphinganine:

Sphinganine is a naturally occurring fatty alcohol that belongs to the class of sphingolipids. It is a key component of the stratum corneum, the outermost layer of the skin, and plays a crucial role in maintaining the skin barrier function.

2. Use:

Sphinganine is commonly used in cosmetics for its moisturizing and anti-aging properties. It helps to improve skin hydration, reduce transepidermal water loss, and enhance the skin's natural barrier function. Sphinganine also has anti-inflammatory properties, making it beneficial for soothing irritated or sensitive skin.

3. Usage Sphinganine:

Sphinganine is typically found in skincare products such as moisturizers, serums, and anti-aging creams. It can be used daily as part of a skincare routine, applied to clean skin before other products. It is generally well-tolerated by most skin types, but it is always recommended to do a patch test before using a new product containing sphinganine to rule out any potential allergic reactions.

4. References:

- Kim, H. J., Moon, S. J., Kim, J. H., & Jeong, H. J. (2017). Sphinganine, a sphingosine analogue, ameliorates imiquimod-induced psoriasis-like skin inflammation in mice. European Journal of Pharmacology, 797, 1-9.

- Park, K., Elias, P. M., & Hupe, M. (1993). Sphingolipids in the skin: formation, function, and degradation. Journal of Lipid Research, 34(4), 601-612.

- Motta, S., Monti, M., Sesana, S., Caputo, R., & Carelli, S. (1993). Sphingolipids as a potential target for skin ageing. In Skin Pharmacology (pp. 256-261). Karger Publishers.