4AM Clean Sheets

1. Definition Caprylic/ Capric Glycerides:

Caprylic/ Capric Glycerides are a mixture of esters of glycerin with caprylic and capric acids, which are medium-chain fatty acids derived from coconut oil. They are commonly used in cosmetics as emollients, emulsifiers, and skin-conditioning agents.

2. Use:

Caprylic/ Capric Glycerides are used in a wide range of cosmetic products such as creams, lotions, and serums. They help to improve the texture of the product, making it easier to apply and spread on the skin. Additionally, they provide moisturizing benefits, leaving the skin feeling soft and smooth.

3. Usage Caprylic/ Capric Glycerides:

Caprylic/ Capric Glycerides are generally considered safe for use in cosmetics. However, it is important to follow the recommended usage levels as specified by the manufacturer. Excessive use of these ingredients may lead to skin irritation or sensitization in some individuals. It is always recommended to perform a patch test before using a product containing Caprylic/ Capric Glycerides to ensure compatibility with your skin.

4. References:

- "Caprylic/Capric Glycerides" by Cosmetics Info, https://cosmeticsinfo.org/ingredient/capryliccapric-glycerides

- "Caprylic/Capric Triglycerides" by The Derm Review, https://thedermreview.com/caprylic-capric-triglycerides/

- "Caprylic/Capric Triglyceride" by Truth In Aging, https://www.truthinaging.com/ingredients/caprylic-capric-triglyceride

1. Definition Dimethicone:

Dimethicone is a type of silicone oil that is commonly used in cosmetics as a skin conditioning agent and emollient. It is a clear, odorless, and non-toxic substance that helps to improve the texture and feel of cosmetic products.

2. Use:

Dimethicone is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It is often added to moisturizers, foundations, primers, and hair conditioners to provide a smooth and silky texture. Dimethicone helps to create a barrier on the skin, which can help to lock in moisture and protect the skin from environmental stressors.

3. Usage Dimethicone:

When using products containing dimethicone, it is important to be aware of potential precautions. While dimethicone is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to do a patch test before using a new product containing dimethicone, especially if you have sensitive skin. Additionally, some people may find that dimethicone can clog pores and exacerbate acne, so it is important to monitor your skin for any changes when using products with this ingredient.

4. References:

- Lanigan, R. S., & Yamarik, T. A. (2002). Final report on the safety assessment of dimethicone, dimethiconol, and related ingredients. International journal of toxicology, 21(1), 7-41.

- Draelos, Z. D. (2010). Cosmetic vehicle efficacy. Dermatologic therapy, 23(4), 314-317.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... & Andersen, F. A. (2016). Safety assessment of dimethicone crosspolymers as used in cosmetics. International journal of toxicology, 35(1_suppl), 5S-24S.

1. Definition Xanthan Gum:

Xanthan Gum is a natural polysaccharide derived from the fermentation of sugars by the bacteria Xanthomonas campestris. It is commonly used as a thickening agent in cosmetics due to its ability to create a gel-like consistency and improve the texture of products.

2. Use:

Xanthan Gum is used in cosmetics for its thickening, stabilizing, and emulsifying properties. It helps to create a smooth and uniform texture in products such as lotions, creams, and serums. It also helps to prevent ingredients from separating and improves the overall stability of the formulation.

3. Usage Xanthan Gum:

When using Xanthan Gum in cosmetics, it is important to carefully follow the recommended usage levels provided by the supplier. Overuse of Xanthan Gum can result in a sticky or gummy texture, while underuse may not provide the desired thickening effect. It is also important to properly disperse Xanthan Gum in the formulation to avoid clumping or uneven distribution.

4. References:

- Silva, E. O., et al. (2018). Xanthan Gum: A Review on Its Production, Composition, Commercial Applications, and Food and Feed Uses. Food and Bioprocess Technology, 11(1), 195-229.

- Kaur, A., et al. (2020). Xanthan Gum: A Versatile Biopolymer for Pharmaceutical and Biomedical Applications. Journal of Polymers and the Environment, 28(7), 1541-1555.

- Li, Z., et al. (2019). Xanthan Gum and Its Applications in Drug Delivery: A Review. Carbohydrate Polymers, 217, 1-8.

1. Definition 1,2-Hexanediol:

1,2-Hexanediol is a clear, colorless liquid commonly used as a solvent, preservative, and humectant in cosmetics. It is a type of glycol that is derived from petroleum.

2. Use:

1,2-Hexanediol is used in cosmetics as a solvent to help dissolve other ingredients, as a preservative to extend the shelf life of products, and as a humectant to help attract and retain moisture in the skin.

3. Usage 1,2-Hexanediol:

When using products containing 1,2-Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing 1,2-Hexanediol to determine if any sensitivity exists.

4. References:

- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol

- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/

- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820

1. Definition Panthenol:

Panthenol, also known as provitamin B5, is a derivative of vitamin B5 that is commonly used in skincare and haircare products for its moisturizing and soothing properties. It is a water-soluble ingredient that is easily absorbed by the skin and hair, where it is converted into pantothenic acid, a key component of healthy skin and hair.

2. Use:

Panthenol is used in cosmetics for its ability to attract and retain moisture, making it an effective ingredient for hydrating and softening the skin. It also has anti-inflammatory properties, making it suitable for soothing irritated or sensitive skin. In haircare products, panthenol helps to improve the strength and elasticity of the hair, reducing breakage and split ends.

3. Usage Panthenol:

Panthenol can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and styling products. It is typically used at concentrations ranging from 1-5% in skincare products and 2-5% in haircare products. Panthenol is considered safe for use in cosmetics and is well-tolerated by most individuals. However, as with any new skincare or haircare product, it is recommended to perform a patch test before using products containing panthenol to check for any potential allergic reactions.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.

1. Definition Sodium Citrate:

Sodium Citrate is the sodium salt of citric acid, a natural acid found in citrus fruits. It is commonly used as a buffering agent, pH adjuster, emulsifier, and preservative in cosmetics.

2. Use:

Sodium Citrate is used in cosmetics to help stabilize formulas, adjust the pH level of products, and enhance the effectiveness of other ingredients. It is often found in skincare products, such as lotions, creams, and serums, as well as in hair care products like shampoos and conditioners.

3. Usage Sodium Citrate:

When using products containing Sodium Citrate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient. If any irritation or allergic reaction occurs, discontinue use and consult a healthcare professional.

4. References:

- "Sodium Citrate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/sodium-citrate.

- "Sodium Citrate." Truth In Aging, www.truthinaging.com/ingredients/sodium-citrate.

- "Sodium Citrate in Cosmetics." Personal Care Council, www.personalcarecouncil.org/ingredient-issues-cosmetic-products/sodium-citrate-in-cosmetics/.

1. Definition Butylene Glycol:

Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.

2. Use:

Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.

3. Usage Butylene Glycol:

Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

1. Definition Escin:

Escin is a natural compound extracted from the seeds of the horse chestnut tree (Aesculus hippocastanum). It is a mixture of saponins that have anti-inflammatory and anti-edematous properties.

2. Use:

Escin is commonly used in cosmetics for its ability to improve the appearance of skin by reducing inflammation, swelling, and redness. It is often found in products targeting conditions such as varicose veins, cellulite, and under-eye puffiness.

3. Usage Escin:

When using cosmetics containing escin, it is important to follow the instructions provided on the product packaging. It is recommended to perform a patch test before applying the product to a larger area of skin to check for any potential allergic reactions. Escin should not be ingested and should be kept out of reach of children.

4. References:

- Arroyo-Maya, I. J., McClements, D. J., & Sánchez-Camargo, A. D. P. (2018). Biopolymer nanoparticles as potential delivery systems for ellagic acid in the food industry. Food Hydrocolloids, 77, 1-13.

- Guo, S., Duan, J. A., Qian, D., & Tang, Y. (2019). Determination of escin in human plasma by LC–MS/MS and its application in a pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis, 165, 199-204.

- Liu, Y., Li, X., Liu, S., & Ye, Y. (2016). Protective effect of escin on myocardial ischemia/reperfusion injury in rats. Experimental and therapeutic medicine, 12(5), 3249-3254.

1. Definition Glycerin:

Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.

2. Use:

Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.

3. Usage Glycerin:

When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.

1. Definition Ruscus Aculeatus Root Extract:

Ruscus Aculeatus Root Extract, also known as Butcher's Broom Extract, is derived from the roots of the Ruscus aculeatus plant. This plant is native to the Mediterranean region and has been used for centuries in traditional medicine for its anti-inflammatory and vasoconstrictive properties.

2. Use:

Ruscus Aculeatus Root Extract is commonly used in cosmetics for its ability to improve circulation, reduce inflammation, and strengthen blood vessels. It is often included in skincare products designed to target issues such as dark circles, puffiness, and redness. Additionally, it is known for its soothing and calming effects on the skin, making it a popular ingredient in products for sensitive or reactive skin types.

3. Usage Ruscus Aculeatus Root Extract:

When using products containing Ruscus Aculeatus Root Extract, it is important to follow the instructions provided by the manufacturer. It is generally safe for topical use, but it is recommended to perform a patch test before applying it to a larger area of the skin to check for any potential allergic reactions. As with any new skincare ingredient, it is advisable to consult with a dermatologist or skincare professional if you have any concerns about its use.

4. References:

- Arnaud, L., et al. (2009). Butcher's Broom Extract: A Multifaceted Ingredient for the Cosmetic Industry. Cosmetic Science Technology, 1-4.

- Guarrera, P. M., & Savo, V. (2013). Perceived health properties of wild and cultivated food plants in local and popular traditions of Italy: A review. Journal of Ethnopharmacology, 146(3), 659-680.

- Piazza, C., et al. (2017). Ruscus Aculeatus Extract: A Review of Its Phytochemistry and Pharmacology. Phytotherapy Research, 31(12), 1853-1869.

1. Definition Ammonium Glycyrrhizate:

Ammonium Glycyrrhizate is a compound derived from licorice root that is commonly used in cosmetics for its skin-soothing and anti-inflammatory properties.

2. Use:

Ammonium Glycyrrhizate is often included in skincare products such as creams, lotions, and serums to help calm and reduce redness in sensitive or irritated skin. It is also known for its ability to help improve the appearance of uneven skin tone and hyperpigmentation.

3. Usage Ammonium Glycyrrhizate:

When using products containing Ammonium Glycyrrhizate, it is important to follow the instructions provided by the manufacturer. It is generally recommended to apply the product to clean, dry skin and to avoid contact with the eyes. Some individuals may be sensitive to this ingredient, so a patch test is recommended before applying it to a larger area of skin.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw-Hill Education.

- Mukherjee, P. K., & Maity, N. (2013). Novel Cosmetic Delivery Systems. CRC Press.

1. Definition Centella Asiatica Leaf Extract:

Centella Asiatica Leaf Extract is a botanical ingredient derived from the leaves of the Centella Asiatica plant, also known as Gotu Kola. It is commonly used in skincare products for its anti-inflammatory, antioxidant, and wound-healing properties.

2. Use:

Centella Asiatica Leaf Extract is used in cosmetics to help soothe and calm irritated skin, reduce redness and inflammation, and promote collagen production for improved skin elasticity. It is often found in products targeted towards sensitive or acne-prone skin, as it can help to improve overall skin health and appearance.

3. Usage Centella Asiatica Leaf Extract:

Centella Asiatica Leaf Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically applied topically to the skin, either as a standalone ingredient or as part of a formulation with other beneficial ingredients. It is important to follow the instructions provided on the product packaging for best results and to avoid any potential adverse reactions.

4. References:

- Choi, J., Kim, H., Kim, Y., Park, S., Kim, J., Lee, D., & Cho, S. (2019). Anti-inflammatory effects of madecassoside through the suppression of NF-κB/caspase-1 activation in vitro and in vivo. Molecules, 24(1), 139.

- Bylka, W., Znajdek-Awizeń, P., Studzińska-Sroka, E., & Brzezińska, M. (2014). Centella asiatica in cosmetology. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 31(1), 46-49.

- Hashim, P., Sidek, H. M., & Helan, M. H. M. (2005). Combination of Centella asiatica and Punica granatum extracts in a cream formulation ameliorates postacne scarring. Journal of Dermatology, 32(11), 945-948.

1. Definition Hydrolyzed Yeast Protein:

Hydrolyzed Yeast Protein is a natural ingredient derived from yeast that has been broken down into smaller peptides through a process called hydrolysis. This ingredient is rich in amino acids, vitamins, minerals, and antioxidants, making it a popular choice in skincare and haircare products.

2. Use:

Hydrolyzed Yeast Protein is known for its ability to improve the overall health and appearance of the skin and hair. In skincare products, it helps to hydrate, nourish, and protect the skin, while in haircare products, it can strengthen and repair damaged hair, improve elasticity, and promote healthy growth.

3. Usage Hydrolyzed Yeast Protein:

When using products containing Hydrolyzed Yeast Protein, it is important to follow the instructions provided by the manufacturer. This ingredient is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using it on larger areas of the skin. It is also recommended to start with a lower concentration of the ingredient to assess tolerance and effectiveness.

4. References:

- Kim, S. K., & Wijesekara, I. (2010). Development and biological activities of marine-derived bioactive peptides: A review. Journal of Functional Foods, 2(1), 1-9.

- Park, P. J., Jung, W. K., & Byun, H. G. (2014). Fish hydrolysates and their bioactive peptides for health benefits. Marine Biotechnology, 16(4), 453-472.

- Senevirathne, M., & Kim, S. (2012). Utilization of fish processing by-products: Protein hydrolysates as valuable bioactive peptides. Advances in Food and Nutrition Research, 65, 495-512.

1. Definition Calendula Officinalis Flower Extract:

Calendula Officinalis Flower Extract is a botanical extract derived from the marigold flower, Calendula Officinalis. It is known for its soothing and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

Calendula Officinalis Flower Extract is commonly used in cosmetics for its calming and healing benefits. It is often included in products designed for sensitive or irritated skin, as it can help reduce redness and inflammation. Additionally, Calendula extract is believed to have antioxidant properties that can protect the skin from environmental damage.

3. Usage Calendula Officinalis Flower Extract:

Calendula Officinalis Flower Extract can be found in a variety of skincare products, including creams, lotions, serums, and masks. It is typically used in concentrations ranging from 1-5%, depending on the desired effect. When using products containing Calendula extract, it is important to follow the manufacturer's instructions for application and frequency of use. Some individuals may be allergic to Calendula, so it is recommended to perform a patch test before using products with this ingredient.

4. References:

- Dweck, A. C. (2002). Calendula officinalis: A review. International Journal of Cosmetic Science, 24(5), 303-306.

- Preethi, K. C., & Kuttan, R. (2009). Wound healing activity of flower extract of Calendula officinalis. Journal of Basic and Clinical Physiology and Pharmacology, 20(1), 73-79.

- Raskovic, A., Milanovic, I., Pavlovic, N., Cebovic, T., Vukmirovic, S., & Mikov, M. (2011). Antioxidant activity of Calendula officinalis L. flower extract. Acta Poloniae Pharmaceutica, 68(5), 793-801.

1. Definition Ethylhexylglycerin:

Ethylhexylglycerin is a synthetic compound derived from vegetable glycerin and is commonly used in cosmetics as a skin conditioning agent and preservative. It is a clear, colorless liquid with a faint odor.

2. Use:

Ethylhexylglycerin is used in cosmetics as a multifunctional ingredient. It acts as a skin conditioning agent, moisturizer, and preservative. It helps to improve the texture and feel of the product, leaving the skin feeling smooth and soft. Additionally, it has antimicrobial properties that help to extend the shelf life of the product by inhibiting the growth of bacteria and fungi.

3. Usage Ethylhexylglycerin:

Ethylhexylglycerin is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often found in skincare products such as moisturizers, lotions, creams, and serums. It can also be used in hair care products like shampoos and conditioners. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing Ethylhexylglycerin to check for any potential allergic reactions.

4. References:

- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.

- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.

- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.

1. Definition Caprylhydroxamic Acid:

Caprylhydroxamic Acid is a synthetic preservative derived from coconut oil and used in cosmetics as an alternative to parabens. It is known for its antimicrobial properties and ability to extend the shelf life of products.

2. Use:

Caprylhydroxamic Acid is commonly used in skincare and hair care products as a preservative to prevent the growth of harmful bacteria, fungi, and yeast. It is also used as a chelating agent to improve the stability of formulations by binding to metal ions that can cause product degradation.

3. Usage Caprylhydroxamic Acid:

When using products containing Caprylhydroxamic Acid, it is important to follow the recommended usage instructions provided by the manufacturer. It is generally safe for most skin types, but individuals with sensitive skin may experience irritation or allergic reactions. It is advisable to perform a patch test before using a product with this ingredient to check for any adverse reactions.

4. References:

- "Caprylhydroxamic Acid" by Cosmetics Info, https://cosmeticsinfo.org/ingredient/caprylhydroxamic-acid

- "Caprylhydroxamic Acid" by The Derm Review, https://thedermreview.com/caprylhydroxamic-acid/

- "Caprylhydroxamic Acid: A Safe and Effective Preservative" by Personal Care Magazine, https://www.personalcaremagazine.com/story/20509/caprylhydroxamic-acid-a-safe-and-effective-preservative