ASDM Beverly Hills Maximum Strength Skin Lightening Body Lotion- With 2% Alpha & 2% Beta Arbutin

1. Definition Polysorbate 80:

2. Use:

3. Usage Polysorbate 80:

4. References:

- Lodeiro, P., Barros, M. A., & Schapoval, E. E. (2013). Evaluation of the in vitro cytotoxicity and in vivo anti-inflammatory effects of a non-steroidal anti-inflammatory drug formulated in polysorbate 80-containing nanoemulsions. Journal of pharmacy & pharmaceutical sciences, 16(4), 549-563.

- Gao, Z., & Li, Y. (2013). Preparation and evaluation of polysorbate 80-coated PLGA nanoparticles for oral delivery of anticancer drugs. Drug development and industrial pharmacy, 39(3), 499-506.

- Murali, S., & Bharath, S. (2014). Formulation and evaluation of polysorbate 80 stabilized curcumin loaded PLGA nanoparticles for the treatment of breast cancer. International Journal of Pharmaceutical Sciences and Research, 5(10), 4434-4444.

1. Definition Kojic Acid:

2. Use:

3. Usage Kojic Acid:

4. References:

- Sarkar, R., Arora, P., & Garg, K. V. (2013). Cosmeceuticals for hyperpigmentation: What is available? Journal of Cutaneous and Aesthetic Surgery, 6(1), 4–11.

- Lim, J. T. (1999). Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid. Dermatologic Surgery, 25(4), 282–284.

- Garcia, A., Fulton, J. E., & Huggins, J. (1999). Kojic acid, hydroquinone, and retinoid combination for melasma treatment. Journal of Drugs in Dermatology, 3(1), 68–72.

1. Definition Alpha Arbutin:

2. Use:

3. Usage Alpha Arbutin:

4. References:

- Arif, T. (2015). Salicylic acid as a peeling agent: a comprehensive review. Clinical, Cosmetic and Investigational Dermatology, 8, 455–461. https://doi.org/10.2147/CCID.S84765

- Boissy, R. E., & Visscher, M. (2006). DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency. Experimental Dermatology, 15(9), 601–608. https://doi.org/10.1111/j.1600-0625.2006.00449.x

- Smit, N., Vicanova, J., & Pavel, S. (2009). The hunt for natural skin whitening agents. International Journal of Molecular Sciences, 10(12), 5326–5349. https://doi.org/10.3390/ijms10125326

1. Definition Helianthus Annuus (Sunflower) Seed Oil:

2. Use:

3. Usage Helianthus Annuus (Sunflower) Seed Oil:

4. References:

- M. S. Khan, M. A. Ali, M. P. Alam, M. A. Parvez, and S. Ahmad, "Phyto-pharmacological perspective of Helianthus annuus L. seeds," Journal of Applied Pharmaceutical Science, vol. 1, no. 8, pp. 35-41, 2011.

- D. R. Kamimura, C. S. de Oliveira, and L. G. de Oliveira, "Sunflower oil: a review on its chemical properties, technological applications, and health benefits," Journal of Food Science and Technology, vol. 57, no. 1, pp. 388-398, 2020.

- L. M. de Souza, D. G. de Oliveira, M. M. M. A. Alves, and R. L. C. Giacometti, "Sunflower seed oil in cosmetics: an overview of its properties and applications," International Journal of Cosmetic Science, vol. 42, no. 4, pp. 313-321, 2020.

1. Definition Oryza Sativa (Rice) Bran Oil:

2. Use:

3. Usage Oryza Sativa (Rice) Bran Oil:

4. References:

- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences, 19(1), 70.

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging, 1(4), 327-348.

- Rizwan, M., Rodriguez-Blanco, I., Harbottle, A., Birch-Machin, M. A., & Watson, R. E. B. (2013). Skin photodamage: how the skin can protect itself. Journal of Cosmetic Dermatology, 12(4), 247-253.

1. Definition Lactic Acid:

2. Use:

3. Usage Lactic Acid:

4. References:

- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.

- Baumann, L. (2009). Cosmetic dermatology: principles and practice. McGraw-Hill Medical.

- Arif, T. (2015). Salicylic acid as a peeling agent: a comprehensive review. Clinical, Cosmetic and Investigational Dermatology, 8, 455.

1. Definition Arbutin:

Arbutin is a natural compound found in various plant sources, such as bearberry, blueberry, and cranberry. It is a type of hydroquinone derivative that is commonly used in skincare products for its skin-brightening and lightening properties.

2. Use:

Arbutin is often included in skincare products, such as serums, creams, and lotions, to help reduce the appearance of dark spots, hyperpigmentation, and uneven skin tone. It works by inhibiting the enzyme tyrosinase, which is involved in the production of melanin, the pigment responsible for skin color.

3. Usage Arbutin:

When using skincare products containing arbutin, it is important to follow the instructions provided by the manufacturer. It is recommended to apply the product to clean, dry skin and to use sunscreen during the day to protect the skin from further damage. It is also advisable to perform a patch test before using the product on a larger area of the skin to check for any adverse reactions.

4. References:

- Arbutin: Mechanism of action and its cosmetic properties. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017965/

- Skin lightening agents: new chemical and plant extracts. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801997/

- A review of the topical effects of arbutin. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958188/

1. Definition Glycolic Acid:

Glycolic acid is a type of alpha hydroxy acid (AHA) derived from sugar cane. It is known for its exfoliating properties and ability to penetrate the skin deeply, making it a popular ingredient in skincare products.

2. Use:

Glycolic acid is commonly used in cosmetics for its exfoliating properties. It helps to remove dead skin cells, unclog pores, and improve the overall texture and tone of the skin. It is often found in products such as cleansers, toners, serums, and peels.

3. Usage Glycolic Acid:

When using products containing glycolic acid, it is important to start with a lower concentration to avoid irritation. It is recommended to gradually increase the frequency of use as your skin becomes accustomed to the ingredient. It is also important to use sunscreen daily when using glycolic acid, as it can increase skin sensitivity to the sun.

Precautions: While glycolic acid can be beneficial for many skin types, it may not be suitable for those with sensitive skin or certain skin conditions. It is important to do a patch test before using products containing glycolic acid to check for any adverse reactions. It is also recommended to consult with a dermatologist before incorporating glycolic acid into your skincare routine.

4. References:

- Ditre, C. M., Griffin, T. D., Murphy, G. F., Sueki, H., & Telegan, B. (1996). Effects of alpha-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study. Journal of the American Academy of Dermatology, 34(2), 187-195.

- Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology, 3, 135-142.

- Sharad, J. (2013). Glycolic acid peel therapy – a current review. Clinical, Cosmetic and Investigational Dermatology, 6, 281-288.

1. Definition Leuconostoc/Radish Root Ferment Filtrate:

2. Use:

3. Usage Leuconostoc/Radish Root Ferment Filtrate:

4. References:

- Alves, A., et al. (2016). Radish (Raphanus sativus L.) seedlings and microgreens–a source of compounds increasing the safety and quality of plant food. Food Chemistry, 213, 286-295.

- Clardy, J., et al. (2013). Leuconostoc kimchii sp. nov., a new species from kimchi. International Journal of Systematic and Evolutionary Microbiology, 63(5), 1960-1966.

- Kim, S. H., et al. (2018). Antimicrobial effect of Radish (Raphanus sativus L.) root against foodborne pathogens. Journal of Food Science, 83(1), 180-186.

1. Definition Lonicera Japonica (Honeysuckle) Flower Extract:

2. Use:

3. Usage Lonicera Japonica (Honeysuckle) Flower Extract:

4. References:

- Kim, J. Y., Kim, S. S., Oh, T. H., & Kim, S. K. (2006). Lonicera japonica Thunb. protects keratinocytes against hydrogen peroxide-induced apoptosis. Journal of ethnopharmacology, 104(2-3), 276-281.

- Lee, J. H., Kim, G. H., & Lee, J. S. (2015). Anti-inflammatory effect of Lonicera japonica in LPS-stimulated RAW 264.7 macrophages. Journal of Korean Medicine, 36(3), 88-97.

- Zhang, Y. J., Huang, Z. Q., & Zhang, Y. (2019). Lonicera japonica Thunb: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. Journal of ethnopharmacology, 245, 112158.

1. Definition Lonicera Caprifolium (Honeysuckle) Flower Extract:

2. Use:

3. Usage Lonicera Caprifolium (Honeysuckle) Flower Extract:

4. References:

- Kim, S. J., et al. (2016). Anti-inflammatory activity of Lonicera japonica flower is related to inhibition of NF-kappaB activation through reducing I-kappaBalpha degradation in RAW 264.7 cells. Journal of Ethnopharmacology, 177, 1-8.

- Park, E. J., et al. (2011). Anti-inflammatory activity of herbal medicines: inhibition of nitric oxide production and tumor necrosis factor-alpha secretion in an activated macrophage-like cell line. The American Journal of Chinese Medicine, 39(5), 943-958.

- Shin, T. Y., et al. (2000). Anti-allergic effects of Lonicera japonica Thunb. In vivo and in vitro. Inflammation Research, 49(5), 254-260.

1. Definition Populus Tremuloides Bark Extract:

2. Use:

3. Usage Populus Tremuloides Bark Extract:

4. References:

- Choi, S. Y., et al. (2016). Anti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root bark. BMC Complementary and Alternative Medicine, 16, 198.

- Lee, S. H., et al. (2017). Anti-inflammatory and anti-oxidative effects of aspen bark extract in RAW 264.7 macrophages. Journal of the Korean Society of Food Science and Nutrition, 46(8), 1015-1022.

- Kim, J. E., et al. (2018). Protective effects of aspen bark extract against UVB-induced skin damage in hairless mice. Journal of Photochemistry and Photobiology B: Biology, 185, 56-63.

1. Definition Gluconolactone:

2. Use:

3. Usage Gluconolactone:

4. References:

- Bhatia, A., & Maisuria, V. (2016). Polyhydroxy acids: A new generation of hydroxy acids. International Journal of Research in Cosmetic Science, 6(1), 1-5.

- Draelos, Z. D. (2005). The latest cosmeceutical approaches for anti-aging. Journal of Cosmetic Dermatology, 4(4), 273-278.

- Obagi, Z. E., & Obagi, S. (2003). Chemical peeling and aging skin. Journal of Geriatric Dermatology, 11(2), 67-71.