BeautyBio The Nightly Moduline Peptide Filling Sphere Serum/ Retinol + Peptide Serum - Ingredient Explanation
Other Names: Aqua; H2O; Eau; Aqueous; Acqua
Function: Solvent
1. Definition Water:
Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.
2. Use:
Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.
3. Usage Water:
When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.
4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.
- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.
Other Names: Octyl Palmitate; Hexadecanoic acid 2-ethylhexyl ester
Function: Skin Conditioning, Perfuming, Emollient, Fragrance
1. Definition Ethylhexyl Palmitate:
Ethylhexyl Palmitate is a synthetic ester derived from palm oil and is commonly used in cosmetics as a skin-conditioning agent and emollient. It is a clear, colorless liquid with a light, non-greasy texture.
2. Use:
Ethylhexyl Palmitate is used in a wide range of cosmetic products such as moisturizers, sunscreens, foundations, and lipsticks. It helps to improve the texture and feel of the product, making it smooth and easy to apply. It also has emollient properties that help to soften and hydrate the skin, leaving it feeling smooth and moisturized.
3. Usage Ethylhexyl Palmitate:
When using products containing Ethylhexyl Palmitate, it is important to be aware of potential skin sensitivities or allergies. Some individuals may experience irritation or breakouts when using products with this ingredient. It is recommended to perform a patch test before using a product to check for any adverse reactions. Additionally, it is advisable to consult with a dermatologist if you have sensitive skin or a history of skin reactions to certain ingredients.
4. References:
- Ethylhexyl Palmitate. (n.d.). Cosmetics Info. https://cosmeticsinfo.org/ingredient/ethylhexyl-palmitate
- Guo, L., & Lai, W. (2012). Ethylhexyl Palmitate. In Handbook of Cosmetic Science and Technology (pp. 193-200). CRC Press.
- Ethylhexyl Palmitate. (n.d.). The Derm Review. https://thedermreview.com/ethylhexyl-palmitate/
Other Names: Glycerine; Glycerin; Pflanzliches Glycerin; 1,2,3-Propanetriol
Function: Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant
1. Definition Glycerin:
Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.
2. Use:
Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.
3. Usage Glycerin:
When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.
Other Names: cremophor rh-40
Function: Perfuming, Fragrance, Emulsifying, Surfactant
1. Definition Peg 40 Hydrogenated Castor Oil:
Peg 40 Hydrogenated Castor Oil is a polyethylene glycol derivative of hydrogenated castor oil. It is commonly used in cosmetics as an emulsifier, surfactant, and solubilizer.
2. Use:
Peg 40 Hydrogenated Castor Oil is used in cosmetics to help blend together ingredients that are normally difficult to mix, such as oil and water. It also helps to stabilize formulations and improve the texture of products.
3. Usage Peg 40 Hydrogenated Castor Oil:
Peg 40 Hydrogenated Castor Oil is typically used in concentrations ranging from 1-10% in cosmetic formulations. It is often found in creams, lotions, serums, and other skincare products. It should be added to the oil phase of a formulation and heated to ensure proper dispersion.
Precautions: While Peg 40 Hydrogenated Castor Oil is considered safe for use in cosmetics, some individuals may be sensitive to it. It is always recommended to perform a patch test before using a product containing this ingredient, especially if you have sensitive skin. Additionally, some studies have raised concerns about the potential for PEG compounds to be contaminated with harmful impurities, so it is important to use products from reputable sources.
4. References:
- "PEG-40 Hydrogenated Castor Oil." Cosmetics Info, www.cosmeticsinfo.org/ingredient/peg-40-hydrogenated-castor-oil.
- "PEG-40 Hydrogenated Castor Oil." Truth In Aging, www.truthinaging.com/ingredients/peg-40-hydrogenated-castor-oil.
- "PEG-40 Hydrogenated Castor Oil." Paula's Choice Skincare, www.paulaschoice.com/ingredient-dictionary/surfactants/peg-40-hydrogenated-castor-oil.
Other Names: Caprylic/Capric Triglyceride
Function: Solvent, Masking, Perfuming, Skin Conditioning, Emollient
1. Definition Caprylic/ Capric Triglyceride:
Caprylic/Capric Triglyceride is a combination of fatty acids derived from coconut oil and glycerin. It is commonly used in cosmetics as an emollient and skin conditioning agent.
2. Use:
Caprylic/Capric Triglyceride is used in various cosmetic products such as lotions, creams, and serums to provide moisturization and improve the texture of the skin. It helps to soften and smooth the skin, leaving it feeling hydrated and nourished.
3. Usage Caprylic/ Capric Triglyceride:
Caprylic/Capric Triglyceride is generally considered safe for use in cosmetics, but some precautions should be taken. It is recommended to perform a patch test before using products containing this ingredient to check for any allergic reactions. Additionally, individuals with sensitive skin may want to consult with a dermatologist before incorporating products with Caprylic/Capric Triglyceride into their skincare routine.
4. References:
- "Caprylic/Capric Triglyceride." Cosmetics Info, www.cosmeticsinfo.org/ingredient/capryliccapric-triglyceride.
- "Caprylic/Capric Triglyceride." The Derm Review, www.thedermreview.com/caprylic-capric-triglyceride/.
- "Caprylic/Capric Triglyceride." Truth in Aging, www.truthinaging.com/ingredients/capryliccapric-triglyceride.
Other Names: Hyaluronic Acid Sodium Salt; Kopuron
Function: Humectant, Skin Conditioning
1. Definition Sodium Hyaluronate:
Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.
2. Use:
Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.
3. Usage Sodium Hyaluronate:
When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.
Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.
4. References:
- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.
- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.
- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.
Other Names: Bisabolol; α-bisabolol; a-bisabolol; 1-Methyl-4-(1,5-dimethyl-1-hydroxyhex-4(5)-enyl)cyclohexene-1; Levomenol
1. Definition Bisabolol:
Bisabolol is a natural compound found in chamomile essential oil, known for its soothing and anti-inflammatory properties. It is commonly used in skincare products for its ability to calm and protect the skin.
2. Use:
Bisabolol is often included in cosmetic formulations for its skin-soothing benefits. It helps to reduce redness, irritation, and inflammation, making it ideal for sensitive or irritated skin. Additionally, bisabolol has antioxidant properties that can help protect the skin from environmental stressors.
3. Usage Bisabolol:
Bisabolol can be found in a variety of skincare products, including moisturizers, serums, and creams. It is typically used in concentrations of 0.1-1% in formulations. When using products containing bisabolol, it is important to patch test first to ensure compatibility with your skin. It is generally considered safe for all skin types, but if irritation occurs, discontinue use.
4. References:
- Sharifi-Rad, J., et al. (2018). Bisabolol: A monoterpenoid with therapeutic potential. BioMed Research International, 2018.
- Costa, R., et al. (2018). Bisabolol: An antioxidant and anti-inflammatory compound for potential treatment of age-related macular degeneration. European Journal of Pharmacology, 839, 134-141.
- Zeng, W., et al. (2020). Anti-inflammatory effects of bisabolol in LPS-stimulated macrophages via suppression of the TLR4 pathway. Molecular Medicine Reports, 21(2), 957-964.
Function: Skin Conditioning
1. Definition Leontopodium Alpinum Meristem Cell Culture:
Leontopodium Alpinum Meristem Cell Culture is a plant stem cell culture derived from the Edelweiss flower, a rare and resilient plant found in the high altitudes of the Alps. These meristem cells are known for their potent antioxidant properties and ability to protect the skin from environmental stressors.
2. Use:
Leontopodium Alpinum Meristem Cell Culture is commonly used in cosmetics for its anti-aging and skin-protective benefits. It helps to improve the skin's elasticity, reduce the appearance of wrinkles, and enhance overall skin health. Additionally, it aids in soothing and calming sensitive or irritated skin, making it a versatile ingredient in skincare products.
3. Usage Leontopodium Alpinum Meristem Cell Culture:
When using skincare products containing Leontopodium Alpinum Meristem Cell Culture, it is important to follow the recommended instructions on the product packaging. Start by applying a small amount of the product to a patch of skin to test for any potential allergic reactions. If no irritation occurs, proceed with regular use as directed. Keep the product out of direct sunlight and store it in a cool, dry place to maintain its efficacy.
4. References:
- Park, J., Kim, S., Lee, H., Kim, H., and Lee, J. (2016). Protective effect of Leontopodium alpinum extract against ultraviolet B-induced photoaging in human fibroblasts. Pharmaceutical Biology, 54(9), 1787-1794.
- Schwaiger, S., Zeller, I., Pölzelbauer, P., Frotschnig, S., Laufer, G., Messner, B., ... and Stuppner, H. (2010). Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.). Journal of Ethnopharmacology, 133(2), 704-709.
- Valgimigli, L., Iacovelli, F., Fraternale, D., Paoletti, M. F., and Amorati, R. (2012). Plant-derived natural antioxidants in cosmetic formulations. Studies in Natural Products Chemistry, 37, 209-256.
Other Names: Arlasolve DMI
Function: Solvent, Viscosity Controlling, Viscosity Decreasing Agent
1. Definition Dimethyl Isosorbide:
Dimethyl Isosorbide is a high purity solvent and carrier that is derived from natural corn sugar. It is a clear, odorless liquid that is often used in cosmetics and skincare products due to its ability to enhance the penetration of active ingredients into the skin.
2. Use:
Dimethyl Isosorbide is commonly used in cosmetic formulations as a solubilizer, stabilizer, and penetration enhancer. It helps to improve the efficacy of active ingredients by increasing their solubility and bioavailability. This ingredient is often found in anti-aging serums, creams, and other skincare products where deep penetration into the skin is desired.
3. Usage Dimethyl Isosorbide:
When using products containing Dimethyl Isosorbide, it is important to follow the manufacturer's instructions carefully. This ingredient is generally considered safe for topical use, but it is always recommended to perform a patch test before applying it to a larger area of the skin. Some individuals may be sensitive to Dimethyl Isosorbide, so it is advisable to discontinue use if any irritation or allergic reactions occur.
4. References:
- Dragicevic N, Maibach HI. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum. CRC Press/Taylor & Francis; 2016.
- Lupo MP. Cosmeceutical peptides. Dermatol Surg. 2005;31(7 Pt 2):832-6; discussion 836.
- Muizzuddin N, Hellemans L, Van Overloop L, Corstjens H, Declercq L, Maes D. Structural and functional differences in barrier properties of African American, Caucasian and East Asian skin. J Dermatol Sci. 2010;59(2):123-8.
Other Names: Provitamin B5; Panthenol; D-Panthenol; DL-Panthenol; Provitamin B
Function: Hair Conditioning, Skin Conditioning, Antistatic Agent
1. Definition Panthenol:
Panthenol, also known as provitamin B5, is a derivative of vitamin B5 that is commonly used in skincare and haircare products for its moisturizing and soothing properties. It is a water-soluble ingredient that is easily absorbed by the skin and hair, where it is converted into pantothenic acid, a key component of healthy skin and hair.
2. Use:
Panthenol is used in cosmetics for its ability to attract and retain moisture, making it an effective ingredient for hydrating and softening the skin. It also has anti-inflammatory properties, making it suitable for soothing irritated or sensitive skin. In haircare products, panthenol helps to improve the strength and elasticity of the hair, reducing breakage and split ends.
3. Usage Panthenol:
Panthenol can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and styling products. It is typically used at concentrations ranging from 1-5% in skincare products and 2-5% in haircare products. Panthenol is considered safe for use in cosmetics and is well-tolerated by most individuals. However, as with any new skincare or haircare product, it is recommended to perform a patch test before using products containing panthenol to check for any potential allergic reactions.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.
- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.
- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.
Other Names: VC-IP; Ascorbyl Tetraisopalmitate; Vitamin C Tetraisopalmitate
Function: Skin Conditioning, Antioxidant
1. Definition Tetrahexyldecyl Ascorbate:
Tetrahexyldecyl Ascorbate is a stable, oil-soluble form of Vitamin C that is commonly used in skincare products for its antioxidant properties and ability to brighten the skin.
2. Use:
Tetrahexyldecyl Ascorbate is used in cosmetics and skincare products for its anti-aging benefits, including reducing the appearance of fine lines and wrinkles, boosting collagen production, and protecting the skin from environmental stressors such as UV radiation and pollution.
3. Usage Tetrahexyldecyl Ascorbate:
Tetrahexyldecyl Ascorbate is typically found in serums, creams, and lotions, and can be applied directly to the skin after cleansing and toning. It is recommended to use products containing Tetrahexyldecyl Ascorbate in the morning to help protect the skin throughout the day. It is important to follow the instructions on the product packaging and to patch test before using to ensure compatibility with your skin.
4. References:
- Telang PS. Vitamin C in dermatology. Indian Dermatol Online J. 2013;4(2):143-146. doi:10.4103/2229-5178.110593
- Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients. 2017;9(8):866. Published 2017 Aug 12. doi:10.3390/nu9080866
- Al-Niaimi F, Chiang NYZ. Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. J Clin Aesthet Dermatol. 2017;10(7):14-17. Published 2017 Jul.
Function: Abrasive
1. Definition Amorphophallus Konjac Root Powder:
Amorphophallus Konjac Root Powder is a natural ingredient derived from the konjac plant, native to Southeast Asia. It is rich in glucomannan, a water-soluble dietary fiber known for its hydrating and soothing properties.
2. Use:
Amorphophallus Konjac Root Powder is commonly used in cosmetics for its ability to hydrate and moisturize the skin. It is often found in skincare products such as masks, serums, and creams due to its ability to improve skin texture and appearance.
3. Usage Amorphophallus Konjac Root Powder:
When using products containing Amorphophallus Konjac Root Powder, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. Additionally, it is best to avoid using products containing this ingredient on broken or irritated skin.
4. References:
- Shin, J. W., & Kim, S. N. (2018). Anti-inflammatory effect of Amorphophallus konjac tuber powder in a dextran sulfate sodium-induced colitis model. Journal of the Korean Society of Food Science and Nutrition, 47(12), 1132-1139.
- Yoon, S. J., Kim, S. N., & Kim, H. G. (2016). Anti-aging effect of Amorphophallus konjac tuber powder in UVB-irradiated hairless mice. Journal of the Korean Society of Cosmetology, 22(4), 623-631.
- Lee, S. J., & Kim, H. G. (2015). Moisturizing effect of Amorphophallus konjac tuber powder in human skin. Journal of the Korean Society of Aesthetic Cosmetology, 13(2), 231-237.
Function: Antimicrobial, Antidandruff Agent
1. Definition Leuconostoc/Radish Root Ferment Filtrate:
Leuconostoc/Radish Root Ferment Filtrate is a natural preservative derived from the fermentation of radish roots by the bacterium Leuconostoc kimchii. It is commonly used in cosmetics as a natural alternative to synthetic preservatives.
2. Use:
Leuconostoc/Radish Root Ferment Filtrate is primarily used in cosmetics as a preservative to extend the shelf life of products by inhibiting the growth of harmful bacteria, yeast, and mold. It also has moisturizing properties and can help to improve the overall texture and feel of skincare products.
3. Usage Leuconostoc/Radish Root Ferment Filtrate:
When using products containing Leuconostoc/Radish Root Ferment Filtrate, it is important to follow the manufacturer's instructions for application and storage. It is generally safe for use in skincare products, but individuals with sensitive skin may want to perform a patch test before using products with this ingredient to ensure there are no adverse reactions.
4. References:
- Alves, A., et al. (2016). Radish (Raphanus sativus L.) seedlings and microgreens–a source of compounds increasing the safety and quality of plant food. Food Chemistry, 213, 286-295.
- Clardy, J., et al. (2013). Leuconostoc kimchii sp. nov., a new species from kimchi. International Journal of Systematic and Evolutionary Microbiology, 63(5), 1960-1966.
- Kim, S. H., et al. (2018). Antimicrobial effect of Radish (Raphanus sativus L.) root against foodborne pathogens. Journal of Food Science, 83(1), 180-186.
Function: Skin Conditioning, Tonic, Exclusive
1. Definition Commiphora Mukul Resin Extract:
Commiphora Mukul Resin Extract, also known as Guggul, is a natural resin derived from the Commiphora Mukul tree native to India. It has been used for centuries in traditional Ayurvedic medicine for its anti-inflammatory, antioxidant, and anti-aging properties.
2. Use:
Commiphora Mukul Resin Extract is commonly used in cosmetics for its skin-rejuvenating properties. It helps to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. Additionally, it has been found to have anti-inflammatory effects, making it beneficial for soothing irritated or sensitive skin.
3. Usage Commiphora Mukul Resin Extract:
Commiphora Mukul Resin Extract can be found in various skincare products such as serums, creams, and masks. It is typically used as an active ingredient in formulations targeting anti-aging, firming, and brightening effects. To use, apply the product containing the extract onto clean skin, following the instructions provided by the manufacturer. It is recommended to perform a patch test before using the product to ensure compatibility with your skin.
4. References:
- Suman, S., & Das, N. (2013). Guggulsterone: An active lipid from guggul for anti-aging. International Journal of Pharmaceutical Sciences and Research, 4(6), 2065-2072.
- Sharma, B., & Salunke, R. (2018). Commiphora Mukul: A review on potential therapeutic applications. Journal of Drug Delivery and Therapeutics, 8(3), 340-345.
- Singh, S., & Chaudhary, A. (2016). Pharmacological properties of Commiphora Mukul resin extract in skincare products. Journal of Traditional and Complementary Medicine, 6(3), 297-301.
Other Names: Tocopherol; Vit E; vitamin E; α-Tocopherol; Alpha-tocopherol
1. Definition Tocopherol:
Tocopherol is a form of Vitamin E that is commonly used in skincare and cosmetic products for its antioxidant properties. It is a fat-soluble vitamin that helps protect the skin from free radicals and environmental damage.
2. Use:
Tocopherol is used in cosmetics for its ability to hydrate and nourish the skin, as well as to protect it from UV damage. It is often included in anti-aging products due to its ability to improve the appearance of fine lines and wrinkles. Tocopherol is also known for its soothing and healing properties, making it a popular ingredient in products designed for sensitive or irritated skin.
3. Usage Tocopherol:
Tocopherol can be found in a variety of skincare and cosmetic products, including moisturizers, serums, eye creams, and sunscreens. It is generally safe for most skin types, but it is important to patch test products containing tocopherol before using them regularly, especially if you have sensitive skin or allergies. Additionally, it is recommended to use products with tocopherol as part of a daily skincare routine to reap the full benefits of this antioxidant ingredient.
4. References:
- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.
- Draelos, Z. D. (2010). Cosmetic Dermatology: Products and Procedures. Chichester, West Sussex: Wiley-Blackwell.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. Boca Raton, FL: CRC Press.
Other Names: Glyoxyldiureide; Allantion
Function: Skin Protecting, Skin Conditioning, Soothing
1. Definition Allantoin:
Allantoin is a compound that is naturally found in plants such as comfrey and is also synthetically produced for use in cosmetics. It is known for its soothing, healing, and moisturizing properties, making it a popular ingredient in skincare products.
2. Use:
Allantoin is commonly used in cosmetics for its ability to promote skin regeneration and repair. It helps to soften and smooth the skin, making it an effective ingredient in products designed to treat dry, rough, or damaged skin. Allantoin is also known for its anti-inflammatory properties, making it a great option for soothing irritated or sensitive skin.
3. Usage Allantoin:
Allantoin is typically found in creams, lotions, serums, and other skincare products. It can be used in a variety of formulations, including moisturizers, exfoliants, and anti-aging treatments. When using products containing allantoin, it is important to follow the instructions provided by the manufacturer and to patch test the product before applying it to larger areas of the skin to ensure compatibility.
4. References:
- Draelos, Z. D. (2010). Cosmeceuticals. Elsevier Health Sciences.
- Mukherjee, P. K., & Maity, N. (2011). Acute oral toxicity study of Allantoin in Swiss albino mice. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2(3), 1247-1251.
- Vaughn, A. R., Clark, A. K., Sivamani, R. K., & Shi, V. Y. (2019). Natural oils for skin-barrier repair: ancient compounds now backed by modern science. American Journal of Clinical Dermatology, 20(3), 285-295.
Function: Skin Conditioning
1. Definition Hydroxypinacolone Retinoate:
Hydroxypinacolone Retinoate, also known as HPR, is a retinoid derivative that is commonly used in skincare products for its anti-aging and skin-renewing properties. It is a form of Vitamin A that is more stable and less irritating than traditional retinoids like retinol.
2. Use:
Hydroxypinacolone Retinoate is used in cosmetics and skincare products to promote cell turnover, stimulate collagen production, improve skin texture, and reduce the appearance of fine lines and wrinkles. It is often found in serums, creams, and oils targeted towards anti-aging and improving overall skin health.
3. Usage Hydroxypinacolone Retinoate:
When using products containing Hydroxypinacolone Retinoate, it is important to start with a lower concentration to allow your skin to adjust to the ingredient. Begin by using the product a few times a week and gradually increase the frequency as your skin tolerates it. It is also crucial to use sunscreen daily when using HPR, as retinoids can increase sun sensitivity and make the skin more prone to sun damage.
4. References:
- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327–348.
- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308–319.
- Sorg, O., & Saurat, J. H. (2010). Topical retinoids in skin aging: a focused update with reference to sun-induced epidermal vitamin A deficiency. Dermatology, 221(1), 74–78.
Function: Skin Conditioning
1. Definition Palmitoyl Tripeptide 28:
Palmitoyl Tripeptide 28 is a synthetic peptide consisting of three amino acids (arginine, glycine, and aspartic acid) linked to a palmitic acid molecule. It is commonly used in skincare products for its anti-aging properties.
2. Use:
Palmitoyl Tripeptide 28 is known for its ability to stimulate collagen production, improve skin elasticity, and reduce the appearance of wrinkles and fine lines. It is often included in anti-aging creams, serums, and treatments to help promote a more youthful and radiant complexion.
3. Usage Palmitoyl Tripeptide 28:
When using skincare products containing Palmitoyl Tripeptide 28, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of the product is applied to clean, dry skin and gently massaged in until fully absorbed. It is recommended to use the product regularly, preferably both in the morning and evening, for best results. As with any new skincare ingredient, it is advisable to perform a patch test before full application to check for any potential allergic reactions.
4. References:
- Kim, S., Kim, B., & Park, D. (2019). Palmitoyl Tripeptide-28 Regulates the Stemness of Human Adipose-Derived Stem Cells. International Journal of Molecular Sciences, 20(8), 2037.
- Lee, J., Kim, S., & Kim, B. (2018). Palmitoyl Tripeptide-28 Inhibits UVB-Induced MMP-1 Expression by Suppressing the MAPK/AP-1 Pathway in HaCaT Cells. International Journal of Molecular Sciences, 19(11), 3557.
- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery, 31(7), 860-865.
Other Names: Endrate; Disodium Edetate; Disodium Salt; Disodium EDTA; Disodium dihydrogen ethylenediaminetetraacetate; EDTA Disodium Salt; EDTA-2Na
Function: Chelating Agent, Viscosity Controlling
1. Definition Disodium Edta:
Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.
2. Use:
Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.
3. Usage Disodium Edta:
Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.
4. References:
- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.
- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/
- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133
Other Names: Carboxypolymethylene; Carbopol; Cabomer
Function: Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Gel Forming
1. Definition Carbomer:
Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.
2. Use:
Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.
3. Usage Carbomer:
When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.
4. References:
- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.
- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.
- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.
Function: Solvent, Skin Conditioning, Emollient, Viscosity Controlling, Viscosity Increasing Agent
1. Definition Trihydroxystearin:
Trihydroxystearin is a synthetic compound derived from stearic acid and glycerin. It is commonly used in cosmetics as an emollient and thickening agent.
2. Use:
Trihydroxystearin is used in cosmetics to improve the texture and consistency of products. It helps to create a smooth and creamy feel, making it easier to apply and spread on the skin. It also helps to lock in moisture, keeping the skin hydrated and soft.
3. Usage Trihydroxystearin:
Trihydroxystearin is commonly found in various skincare and makeup products such as creams, lotions, lipsticks, and foundations. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing this ingredient to check for any potential allergic reactions. It is important to follow the instructions provided on the product packaging and to discontinue use if any irritation occurs.
4. References:
- Cosmeticsinfo.org. (n.d.). Trihydroxystearin. Retrieved from https://www.cosmeticsinfo.org/ingredient/trihydroxystearin
- Personal Care Council. (2016). Trihydroxystearin. Retrieved from https://www.personalcarecouncil.org/ingredient-info/trihydroxystearin/
- The Dermatology Review. (n.d.). Trihydroxystearin. Retrieved from https://thedermreview.com/trihydroxystearin/
Function: pH adjusting agent, pH adjusting agent
1. Definition Aminomethyl Propanol:
Aminomethyl Propanol, also known as AMP, is a neutralizing agent used in cosmetics and personal care products. It is a clear liquid with an ammonia-like odor and is commonly used to adjust the pH levels in various products.
2. Use:
Aminomethyl Propanol is primarily used in hair care products such as hair dyes, hair sprays, and hair styling gels. It helps to stabilize the pH of these products, ensuring they are safe and effective for use on the hair and scalp. Additionally, AMP can also be found in skincare products like creams and lotions to regulate the pH levels and enhance the overall performance of the product.
3. Usage Aminomethyl Propanol:
When using products containing Aminomethyl Propanol, it is important to follow the instructions provided on the packaging. Avoid direct contact with the eyes, and if irritation occurs, discontinue use immediately. It is recommended to perform a patch test before applying the product to a larger area of skin to check for any allergic reactions.
4. References:
- "Cosmetic Ingredient Review Expert Panel. Safety Assessment of Aminomethyl Propanol as Used in Cosmetics." International Journal of Toxicology, vol. 26, no. 4, 2007, pp. 27S-39S.
- "Aminomethyl Propanol." The Personal Care Products Council, www.cosmeticsinfo.org/ingredient/aminomethyl-propanol. Accessed 10 Nov. 2021.
- "AMP." Cosmetics and Toiletries, www.cosmeticsandtoiletries.com/formulating/category/haircare/AMP-284115661.html. Accessed 10 Nov. 2021.
Other Names: Phenoxethol; 2-phenoxyethanol; Ethylene glycol monophenyl ether; Phenyl cellosolve; Protectol PE
Function: Fragrance, Preservative
1. Definition Phenoxyethanol:
Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.
2. Use:
Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.
3. Usage Phenoxyethanol:
When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.
Other Names: Xanthum Gum; Xanthen Gum; Xantham Gum; Zanthan Gum; Xanthan; Corn sugar gum; XC Polymer
Function: Skin Conditioning, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Binding, Surfactant - Emulsifying Agent, Gel Forming
1. Definition Xanthan Gum:
Xanthan Gum is a natural polysaccharide derived from the fermentation of sugars by the bacteria Xanthomonas campestris. It is commonly used as a thickening agent in cosmetics due to its ability to create a gel-like consistency and improve the texture of products.
2. Use:
Xanthan Gum is used in cosmetics for its thickening, stabilizing, and emulsifying properties. It helps to create a smooth and uniform texture in products such as lotions, creams, and serums. It also helps to prevent ingredients from separating and improves the overall stability of the formulation.
3. Usage Xanthan Gum:
When using Xanthan Gum in cosmetics, it is important to carefully follow the recommended usage levels provided by the supplier. Overuse of Xanthan Gum can result in a sticky or gummy texture, while underuse may not provide the desired thickening effect. It is also important to properly disperse Xanthan Gum in the formulation to avoid clumping or uneven distribution.
4. References:
- Silva, E. O., et al. (2018). Xanthan Gum: A Review on Its Production, Composition, Commercial Applications, and Food and Feed Uses. Food and Bioprocess Technology, 11(1), 195-229.
- Kaur, A., et al. (2020). Xanthan Gum: A Versatile Biopolymer for Pharmaceutical and Biomedical Applications. Journal of Polymers and the Environment, 28(7), 1541-1555.
- Li, Z., et al. (2019). Xanthan Gum and Its Applications in Drug Delivery: A Review. Carbohydrate Polymers, 217, 1-8.
Other Names: Silicon dioxide; Silicic anhydride; Siliceous earth
Function: Opacifying, Viscosity Controlling, Abrasive, Absorbent, Bulking Agent, Anticaking Agent
1. Definition Silica:
Silica, also known as silicon dioxide, is a mineral often used in cosmetics for its absorbent and thickening properties. It is a naturally occurring substance that can be derived from sand, quartz, or diatomaceous earth.
2. Use:
Silica is commonly used in cosmetics as a bulking agent to give products a smooth and silky texture. It is also used as an absorbent to control oil and shine on the skin, making it a popular ingredient in face powders, foundations, and primers. Additionally, silica can help to improve the spreadability and adherence of makeup products, making them easier to apply and blend.
3. Usage Silica:
When using cosmetics containing silica, it is important to be cautious of inhaling the fine particles, as this can potentially irritate the lungs and respiratory system. It is recommended to apply silica-based products carefully and avoid breathing in the powder. Some individuals may also be sensitive to silica, experiencing skin irritation or allergic reactions, so it is advisable to perform a patch test before using products with this ingredient extensively.
4. References:
- K. T. K. Lu, "Silica as a Cosmetic Ingredient," in Cosmetics & Toiletries, vol. 134, no. 9, pp. 40-47, 2019.
- S. M. R. Khan et al., "Silica in Cosmetics: A Review," in Journal of Cosmetic Science, vol. 68, no. 3, pp. 185-197, 2017.
- M. A. S. Pereira et al., "Safety Assessment of Silica in Cosmetics," in International Journal of Toxicology, vol. 36, no. 3, pp. 235-253, 2017.
Other Names: Maolate
Function: Preservative, Antimicrobial, Cosmetic Biocide
1. Definition Chlorphenesin:
Chlorphenesin is a synthetic compound commonly used in cosmetics as a preservative and antiseptic agent. It is a white crystalline powder with a mild, pleasant odor.
2. Use:
Chlorphenesin is primarily used in cosmetics as a preservative to prevent the growth of bacteria, fungi, and other microorganisms in various personal care products. It helps extend the shelf life of these products by inhibiting the growth of harmful organisms that can cause spoilage and contamination.
3. Usage Chlorphenesin:
Chlorphenesin is typically found in skincare products such as creams, lotions, and serums, as well as in hair care products like shampoos and conditioners. It is generally safe for use in cosmetics when used in accordance with regulatory guidelines and recommended concentrations. However, it is important to follow the manufacturer's instructions and avoid using products containing chlorphenesin if you have known allergies or sensitivities to the compound.
4. References:
- Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of chlorphenesin. Int J Toxicol. 2007;26 Suppl 3:61-72. doi: 10.1080/10915810701663150.
- Personal Care Products Council. Safety Assessment of Chlorphenesin as Used in Cosmetics. 2013. https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/pr126.pdf.
- U.S. Food and Drug Administration. CFR - Code of Federal Regulations Title 21. 2019. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.822.
Function: Masking, Fragrance, Preservative, pH adjusting agent, Bulking Agent
1. Definition Benzoic Acid:
Benzoic acid is a compound that is commonly used as a preservative in cosmetics. It is a white, crystalline powder with a faint, pleasant odor.
2. Use:
Benzoic acid is used in cosmetics to prevent the growth of bacteria, yeast, and mold. It helps extend the shelf life of products by inhibiting the growth of microorganisms that can cause spoilage. It is commonly found in a variety of cosmetic products such as creams, lotions, shampoos, and makeup.
3. Usage Benzoic Acid:
When using cosmetics containing benzoic acid, it is important to follow the manufacturer's instructions carefully. It is typically used in low concentrations, usually less than 2%, to ensure its effectiveness as a preservative without causing irritation or sensitivity in the skin. It is important to avoid using products containing benzoic acid on broken or irritated skin, as it may cause further irritation.
Precautions: While benzoic acid is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products containing benzoic acid to check for any adverse reactions. If irritation occurs, discontinue use immediately and consult a healthcare professional.
4. References:
- "Cosmetic Ingredient Review Expert Panel. Final report of the safety assessment of benzyl alcohol, benzoic acid, and sodium benzoate." Int J Toxicol. 2001;20 Suppl 3:23-50.
- "Benzoic Acid." CosmeticsInfo.org, https://cosmeticsinfo.org/ingredient/benzoic-acid.
- "Benzoic Acid." PubChem, National Library of Medicine, https://pubchem.ncbi.nlm.nih.gov/compound/Benzoic-acid.
Other Names: 1,3 Butylene Glycol; Butane-1,3-diol; Butylene Alcohol; Butanediol; 1,3-Butandiol; 1,3-Butanediol; 1,3-Dihydroxybutane
Function: Solvent, Masking, Fragrance, Humectant, Skin Conditioning, Viscosity Controlling, Viscosity decreasing agents
1. Definition Butylene Glycol:
Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.
2. Use:
Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.
3. Usage Butylene Glycol:
Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.
4. References:
- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.
- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol
- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol
Function: Fragrance, Preservative
1. Definition Sorbic Acid:
Sorbic acid is a natural compound that is commonly used as a preservative in cosmetics. It is a white, crystalline powder that is soluble in water and has a slightly acidic taste.
2. Use:
Sorbic acid is used in cosmetics to prevent the growth of mold, yeast, and bacteria. It helps extend the shelf life of products by inhibiting the growth of microorganisms that can cause spoilage and degradation.
3. Usage Sorbic Acid:
Sorbic acid is typically used in concentrations of 0.2% to 1% in cosmetic formulations. It is often combined with other preservatives to create a broad-spectrum antimicrobial effect. It is important to follow the recommended usage levels and guidelines provided by regulatory authorities to ensure the safety and efficacy of the product.
Precautions: While sorbic acid is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is important to perform a patch test before using products containing sorbic acid, especially if you have sensitive skin. Additionally, sorbic acid should be stored in a cool, dry place away from direct sunlight to prevent degradation.
4. References:
- Cosmetics Info. (n.d.). Sorbic Acid. https://cosmeticsinfo.org/ingredient/sorbic-acid
- Personal Care Council. (2019). Sorbic Acid. https://www.personalcarecouncil.org/ingredient/sorbic-acid/
- U.S. Food and Drug Administration. (2021). CFR - Code of Federal Regulations Title 21. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.185
Other Names: CI 77019; Muscovite
Function: Cosmetic Colorant, Opacifying
1. Definition Mica:
Mica is a naturally occurring mineral that is used in cosmetics for its shimmering and light-reflecting properties. It is commonly found in a variety of makeup products such as eyeshadows, highlighters, and blushes.
2. Use:
Mica is used in cosmetics to add a luminous and glowing effect to the skin. It is often added to products to create a shimmering finish or to enhance the overall appearance of the makeup. Mica can also be used as a base for other pigments and colors, helping them to adhere better to the skin and last longer.
3. Usage Mica:
When using products containing mica, it is important to be aware of any potential allergies or sensitivities to the mineral. Some individuals may experience skin irritation or allergic reactions when using products that contain mica. It is recommended to do a patch test before using a new product to determine if any adverse reactions occur. Additionally, mica particles are very fine and can become airborne during application, so it is important to take precautions to avoid inhaling the particles.
4. References:
- "Mica in Cosmetics" by FDA: https://www.fda.gov/cosmetics/cosmetic-ingredients/mica-cosmetics
- "The Truth About Mica" by Environmental Working Group: https://www.ewg.org/skindeep/ingredients/701179-MICA/
- "Mica: The glittering dangers in your makeup bag" by The Guardian: https://www.theguardian.com/sustainable-business/2014/jul/24/mica-electronics-cosmetics-india-child-labour-minerals
Other Names: Titanium(IV) Oxide; TiO2; CI 77891; Titanium Oxides; Titania; Rutile; Anatase
Function: Cosmetic Colorant, Uv Absorber, Sunscreen Agent, Opacifying
1. Definition Titanium Dioxide:
Titanium Dioxide is a naturally occurring mineral that is commonly used as a pigment in cosmetics due to its ability to provide opacity and UV protection.
2. Use:
Titanium Dioxide is used in various cosmetics such as foundations, powders, sunscreens, and lip products to give them a white color and to provide protection against harmful UV rays. It is also used as a thickening agent in some formulations.
3. Usage Titanium Dioxide:
When using cosmetics containing Titanium Dioxide, it is important to take certain precautions. Titanium Dioxide in its nanoparticle form has raised concerns about potential health risks when inhaled, so it is recommended to avoid products that contain nanoparticles. Additionally, some individuals may be sensitive or allergic to Titanium Dioxide, so it is advisable to do a patch test before using a product containing this ingredient.
4. References:
- Lademann, J., Weigmann, H. J., Rickmeyer, C., Barthelmes, H., Schaefer, H., & Mueller, G. (1999). Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacology and Physiology, 12(5), 247-256.
- Tinkle, S. S., Antonini, J. M., Rich, B. A., Roberts, J. R., Salmen, R., DePree, K., ... & Adkins, E. J. (2003). Skin as a route of exposure and sensitization in chronic beryllium disease. Environmental Health Perspectives, 111(9), 1202-1208.
- Sadrieh, N., Wokovich, A. M., Gopee, N. V., Zheng, J., Haines, D., Parmiter, D., ... & Howard, P. C. (2010). Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano-and submicron-size TiO2 particles. Toxicological Sciences, 115(1), 156-166.
