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1. Definition Sorbitan Olivate:

Sorbitan Olivate is an emulsifier derived from olive oil and sorbitol. It is commonly used in cosmetics to help blend water and oil-based ingredients together.

2. Use:

Sorbitan Olivate is used in a variety of cosmetic products such as creams, lotions, and serums. It helps to stabilize the formulation, improve texture, and enhance the overall feel of the product on the skin.

3. Usage Sorbitan Olivate:

When using products containing Sorbitan Olivate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the skin. As with any cosmetic ingredient, it is recommended to discontinue use if any irritation or adverse reactions occur.

4. References:

- Rizzi, V., L. Cavaletti, L. Battaglia, and C. Banchelli. "Sorbitan Olivate: A Natural Alternative to Synthetic Emulsifiers." International Journal of Cosmetic Science 34, no. 1 (2012): 73-81.

- Lopes, L. B., and S. L. Bentley. "Sorbitan Olivate: A Natural Multifunctional Biomimetic Emulsifier." Journal of Cosmetic Dermatology 11, no. 4 (2012): 298-305.

- Puglia, C., L. Offerta, M. Saija, G. Trombetta, and M. G. Vento. "Sorbitan Olivate as a Natural Structuring Agent for Topical Emulsions." International Journal of Pharmaceutics 441, no. 1-2 (2013): 256-63.

1. Definition Gentiana Scabra Root Extract:

Gentiana Scabra Root Extract is an extract derived from the roots of the Gentiana Scabra plant, also known as Japanese gentian. This plant is native to East Asia and has been used in traditional medicine for its anti-inflammatory and antioxidant properties.

2. Use:

Gentiana Scabra Root Extract is commonly used in cosmetics for its skin-soothing and anti-aging benefits. It is known to help reduce redness and inflammation, as well as protect the skin from environmental stressors. This extract is also believed to promote collagen production, resulting in firmer and more youthful-looking skin.

3. Usage Gentiana Scabra Root Extract:

Gentiana Scabra Root Extract is typically found in skincare products such as serums, creams, and masks. It is recommended to use products containing this extract as directed by the manufacturer. It is important to perform a patch test before applying the product to the entire face to check for any allergic reactions. Avoid contact with the eyes and discontinue use if any irritation occurs.

4. References:

- Kim, S. H., Park, M. J., Lee, J. W., Park, J. H., Kim, D. H., Lee, Y. C., ... & Kim, I. S. (2010). Anti-inflammatory and anti-nociceptive effects of the extract from the roots of Gentiana scabra. Biomolecules & therapeutics, 18(1), 109-115.

- Lee, J. H., Kim, H. L., Lee, M. H., You, Y. O., Lee, J. H., Lee, J. H., & Kim, H. R. (2016). Anti-inflammatory effect of Gentiana scabra Bunge in allergic asthma. Journal of Ethnopharmacology, 191, 41-50.

- Kim, S. H., Kim, D. H., Lee, Y. C., & Kim, I. S. (2011). Inhibitory effect of the extract from the roots of Gentiana scabra on the degranulation of mast cells. Biomolecules & therapeutics, 19(1), 117-122.

1. Definition Cetearyl Alcohol:

Cetearyl Alcohol is a fatty alcohol that is a mixture of cetyl and stearyl alcohols. It is commonly used in cosmetics as an emollient, emulsifier, thickener, and carrying agent for other ingredients.

2. Use:

Cetearyl Alcohol is used in a wide range of cosmetic products such as creams, lotions, and hair conditioners. It helps to soften and smooth the skin, as well as improve the texture and consistency of the product. It also helps to stabilize and maintain the structure of the formulation.

3. Usage Cetearyl Alcohol:

When using products containing Cetearyl Alcohol, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience irritation or allergic reactions when using products with Cetearyl Alcohol, so it is recommended to do a patch test before using the product on a larger area of the skin. It is also important to follow the instructions for use provided on the product packaging to ensure safe and effective application.

4. References:

- "Cetearyl Alcohol" by Paula Begoun, Cosmetics Cop, https://www.paulaschoice.com/ingredient-dictionary/emollients/cetearyl-alcohol.html

- "Cetearyl Alcohol in Cosmetics: Safe or Harmful?" by Dr. Anvita Arora, Dermatologist, https://www.dranvitaarora.com/cetearyl-alcohol-in-cosmetics-safe-or-harmful/

- "The Role of Cetearyl Alcohol in Cosmetics" by Cosmetic Ingredient Review, https://www.cir-safety.org/sites/default/files/cetearylcir.pdf

1. Definition Carbomer:

Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.

2. Use:

Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.

3. Usage Carbomer:

When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.

4. References:

- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.

- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.

- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.

1. Definition Arginine:

Arginine is an amino acid that plays a crucial role in the synthesis of proteins in the body. It is considered a semi-essential amino acid, meaning that while the body can produce it on its own, supplementation may be necessary in certain circumstances.

2. Use:

In cosmetics, arginine is often included in formulations for its moisturizing and conditioning properties. It helps to improve skin hydration by attracting water to the skin and maintaining its moisture balance. Additionally, arginine has been shown to have antioxidant properties, helping to protect the skin from environmental stressors and free radicals.

3. Usage Arginine:

Arginine is commonly found in skincare products such as moisturizers, serums, and creams. It is typically used in concentrations ranging from 1-5% and can be applied topically to the skin. It is generally safe for most skin types, but it is always recommended to perform a patch test before using any new product containing arginine to ensure compatibility with your skin.

4. References:

- Yoon, H. S., Kim, J. R., Park, G. Y., Kim, J. E., Lee, D. H., & Lee, K. W. (2012). Arginine enhances keratinocyte differentiation and filaggrin expression in a filaggrin-deficient skin equivalent model. Biomolecules & therapeutics, 20(3), 292-298.

- Schürer, N., Schliep, V., Williams, J. D., & Imhof, D. (2008). The skin aging exposome. Journal of Drugs in Dermatology, 7(2), s2-s6.

- Kieffer, M. E., & Repka, M. A. (2016). Arginine-based materials for wound healing: State-of-the-art review. Journal of Pharmaceutical Sciences, 105(9), 2675-2686.

1. Definition Paeonia Suffruticosa Root Extract:

Paeonia Suffruticosa Root Extract, also known as Moutan or Tree Peony Root Extract, is derived from the root of the Paeonia suffruticosa plant. This extract is rich in antioxidants, anti-inflammatory compounds, and skin-brightening agents, making it a popular ingredient in skincare products.

2. Use:

Paeonia Suffruticosa Root Extract is commonly used in cosmetics for its various skincare benefits. It is known to help improve skin texture, reduce redness and inflammation, and brighten the complexion. Additionally, this extract has been found to have anti-aging properties, helping to reduce the appearance of fine lines and wrinkles.

3. Usage Paeonia Suffruticosa Root Extract:

Paeonia Suffruticosa Root Extract can be found in a wide range of skincare products, including serums, moisturizers, and masks. It is typically used in concentrations ranging from 0.1% to 2% in formulations. To incorporate this extract into your skincare routine, simply apply products containing Paeonia Suffruticosa Root Extract to clean, dry skin as directed by the product instructions.

4. References:

- Lee JH, Kim GH. Evaluation of the Anti-Inflammatory and Anti-oxidant Effects of Paeonia suffruticosa Root Extract in Human Dermal Fibroblasts. Int J Mol Sci. 2015;16(3):6422-6435. doi:10.3390/ijms16036422

- Li Z, Li J, Ma H, et al. Paeonia suffruticosa Andr. and its active constituent 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose have potent anti-inflammatory activity in activated microglia. J Ethnopharmacol. 2018;211:285-294. doi:10.1016/j.jep.2017.08.015

- Kim JH, Kim YS, Song GY, Kim WH. Antiwrinkle effect of Paeonia suffruticosa. J Cosmet Sci. 2006;57(2):121-130.

1. Definition Salvia Miltiorrhiza Extract:

Salvia Miltiorrhiza Extract, also known as Danshen extract, is derived from the roots of the Salvia miltiorrhiza plant. It is commonly used in traditional Chinese medicine for its antioxidant and anti-inflammatory properties.

2. Use:

Salvia Miltiorrhiza Extract is commonly used in cosmetics for its skin-rejuvenating properties. It is known to improve blood circulation, promote collagen production, and reduce inflammation, making it a popular ingredient in anti-aging and skincare products.

3. Usage Salvia Miltiorrhiza Extract:

Salvia Miltiorrhiza Extract can be found in various skincare products such as serums, creams, and masks. It is typically used in small concentrations and should be applied topically to the skin. It is important to follow the instructions on the product packaging and perform a patch test before using it to avoid any potential allergic reactions.

4. References:

- Chen, Y., Wu, Q., Song, L., He, T., Li, Y., & Li, Y. (2018). Salvianolic acid B protects against acute pancreatitis by inhibiting NF-κB activation via SIRT1 in mice. Molecular Medicine Reports, 17(5), 6727-6734.

- Li, X., Liu, J., Lin, J., Wang, T., Huang, J., Lin, Y., ... & Lin, L. (2019). Salvianolic acid B suppresses in vitro metabolic disorders and alleviates inflammation in cell and mice models of non-alcoholic fatty liver disease. Frontiers in Pharmacology, 10, 1-12.

- Zhang, Y., Zhang, J., Sheng, H., Li, H., Wang, R., Chen, L., ... & Zhang, J. (2018). Salvianolic acid B protects against lipopolysaccharide-induced behavioral deficits and neuroinflammatory response: involvement of autophagy and NLRP3 inflammasome. Journal of Neuroinflammation, 15(1), 1-16.

1. Definition Sophora Flavescens (Ku Shen) Extract:

Sophora Flavescens (Ku Shen) Extract is a natural extract derived from the roots of the Sophora flavescens plant. It is known for its anti-inflammatory, antioxidant, and antimicrobial properties, making it a popular ingredient in skincare and cosmetic products.

2. Use:

Sophora Flavescens Extract is commonly used in cosmetics for its ability to soothe and calm irritated skin, reduce redness and inflammation, and protect against environmental stressors. It is also believed to have brightening and anti-aging effects, making it a versatile ingredient in various skincare formulations.

3. Usage Sophora Flavescens (Ku Shen) Extract:

When using products containing Sophora Flavescens Extract, it is important to follow the recommended usage instructions provided by the manufacturer. It is generally safe for topical application, but it is always advisable to perform a patch test before using any new product to check for any potential allergic reactions or sensitivities. Additionally, it is recommended to avoid using products containing Sophora Flavescens Extract on broken or damaged skin to prevent any adverse reactions.

4. References:

- Park, J., Kim, H., & Lee, J. (2011). Antibacterial activity of Sophora flavescens against methicillin-resistant Staphylococcus aureus. Phytotherapy Research, 25(12), 1776-1778.

- Kim, S. H., Kim, Y. S., Kang, S. S., & Bae, K. (2005). The effect of Sophora flavescens Aiton extract on atopic dermatitis-like skin lesions in NC/Nga mice. Biological & Pharmaceutical Bulletin, 28(10), 2022-2027.

- Lee, J. H., Kim, Y. G., Raorane, C. J., Ryu, S. Y., Kim, Y. H., & Kim, Y. (2015). In vitro and in vivo anti-inflammatory effect of Sophora flavescens extract by down-regulation of MMP-9/MMP-2 in an atopic dermatitis-like skin inflammation model. Journal of Ethnopharmacology, 168, 186-194.

1. Definition Melaleuca Alternifolia (Tea Tree) Leaf Oil:

Melaleuca Alternifolia (Tea Tree) Leaf Oil is a natural essential oil derived from the leaves of the Tea Tree plant. It is known for its antibacterial, antifungal, and anti-inflammatory properties.

2. Use:

Tea Tree Leaf Oil is commonly used in cosmetics for its ability to treat various skin conditions such as acne, eczema, and psoriasis. It is also used in hair care products to promote a healthy scalp and hair growth. Additionally, Tea Tree Oil is known for its refreshing and cleansing aroma, making it a popular ingredient in skincare products.

3. Usage Melaleuca Alternifolia (Tea Tree) Leaf Oil:

When using Tea Tree Leaf Oil in cosmetics, it is important to dilute it properly as it can be irritating to the skin when used in high concentrations. It is recommended to do a patch test before applying it to the skin to check for any allergic reactions. Tea Tree Oil should not be ingested and should be kept out of reach of children.

4. References:

- Carson, C. F., Hammer, K. A., & Riley, T. V. (2006). Melaleuca alternifolia (Tea Tree) oil: a review of antimicrobial and other medicinal properties. Clinical Microbiology Reviews, 19(1), 50-62.

- Hammer, K. A., Carson, C. F., & Riley, T. V. (2012). Antifungal activity of the components of Melaleuca alternifolia (tea tree) oil. Journal of Applied Microbiology, 95(4), 853-860.

- Pazyar, N., Yaghoobi, R., Bagherani, N., & Kazerouni, A. (2013). A review of applications of tea tree oil in dermatology. International Journal of Dermatology, 52(7), 784-790.

1. Definition Centella Asiatica Extract:

Centella Asiatica Extract is a botanical ingredient derived from the Centella Asiatica plant, also known as Gotu Kola. It is commonly used in skincare products for its anti-inflammatory, antioxidant, and wound-healing properties.

2. Use:

Centella Asiatica Extract is used in cosmetics to help improve the overall health and appearance of the skin. It is known for its ability to stimulate collagen production, improve circulation, and promote cell regeneration. This can result in smoother, firmer, and more youthful-looking skin.

3. Usage Centella Asiatica Extract:

Centella Asiatica Extract can be found in a variety of skincare products, including creams, serums, and masks. It is typically used in concentrations ranging from 0.5% to 5%. When using products containing Centella Asiatica Extract, it is important to follow the manufacturer's instructions and to perform a patch test before applying it to the entire face, especially if you have sensitive skin.

4. References:

- Lee J, Jung E, Lee J, Huh S, Kim J, Park M. (2008). Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. Journal of Ethnopharmacology, 127(3), 589-95.

- Bylka W, Znajdek-Awizyn A, Studzinska-Sroka E, Brzezinska M. (2013). Centella asiatica in cosmetology. Advances in Dermatology and Allergology, 30(1), 46-49.

- Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. (1999). In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. Journal of Ethnopharmacology, 65(1), 1-11.

1. Definition Hamamelis Virginiana (Witch Hazel) Extract:

Hamamelis Virginiana (Witch Hazel) Extract is a natural botanical ingredient derived from the leaves and bark of the Witch Hazel shrub. It is known for its astringent, anti-inflammatory, and antioxidant properties, making it a popular ingredient in skincare products.

2. Use:

Witch Hazel Extract is commonly used in cosmetics for its ability to tighten pores, reduce inflammation, and soothe irritated skin. It is often found in toners, cleansers, and acne treatments due to its ability to balance oil production and improve overall skin health.

3. Usage Hamamelis Virginiana (Witch Hazel) Extract:

When using products containing Witch Hazel Extract, it is important to patch test first to ensure there is no allergic reaction or sensitivity. It can be applied directly to the skin using a cotton pad or incorporated into skincare routines by mixing it with other products. Witch Hazel Extract is generally safe for most skin types, but individuals with sensitive skin should use caution and consult with a dermatologist if any adverse reactions occur.

4. References:

- Dweck, A. C. (2002). The botanical and cosmetic use of Witch Hazel. International Journal of Cosmetic Science, 24(1), 17-24.

- Thring, T. S. A., Hili, P., & Naughton, D. P. (2011). Antioxidant and potential anti-inflammatory activity of extracts and formulations of white tea, rose, and witch hazel on primary human dermal fibroblast cells. Journal of Inflammation, 8(1), 27.

- Hughes-Formella, B. J., Filbry, A. W., Gassmueller, J., & Rippke, F. (2002). Anti-inflammatory efficacy of topical preparations with 10% hamamelis distillate in a UV erythema test. Skin Pharmacology and Physiology, 15(2), 125-132.

1. Definition Triethanolamine:

Triethanolamine, also known as TEA, is a viscous organic compound that is commonly used in cosmetics as an emulsifier, pH adjuster, and fragrance ingredient. It is a clear, colorless liquid with a slight ammonia-like odor.

2. Use:

Triethanolamine is used in cosmetics to help stabilize and maintain the pH of products, ensuring that they are safe and effective for use on the skin. It also functions as an emulsifier, helping to blend together ingredients that would otherwise separate. Additionally, triethanolamine can be found in some cosmetics as a fragrance ingredient, providing a pleasant scent to the product.

3. Usage Triethanolamine:

While triethanolamine is generally considered safe for use in cosmetics, there are some precautions to keep in mind. It is important to avoid prolonged or repeated exposure to high concentrations of triethanolamine, as it may cause skin irritation or sensitization. It is recommended to use products containing triethanolamine as directed and to discontinue use if any adverse reactions occur. Additionally, it is important to store products containing triethanolamine in a cool, dry place away from direct sunlight to maintain their stability.

4. References:

- Cosmeticsinfo.org. (n.d.). Triethanolamine. https://cosmeticsinfo.org/ingredient/triethanolamine

- Personal Care Products Council. (2013). Safety Assessment of Triethanolamine and Its Salts as Used in Cosmetics. https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/pr108.pdf

- U.S. Food and Drug Administration. (2019). Code of Federal Regulations Title 21: Triethanolamine. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=73.2120

1. Definition Disodium Edta:

Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.

2. Use:

Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.

3. Usage Disodium Edta:

Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.

4. References:

- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/

- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133

1. Definition Menthyl Lactate:

Menthyl Lactate is a compound derived from menthol and lactic acid. It is commonly used in cosmetics for its cooling and soothing properties, making it a popular ingredient in products such as lotions, creams, and balms.

2. Use:

Menthyl Lactate is known for its ability to provide a cooling sensation on the skin, making it a popular ingredient in products designed to soothe and refresh. It is often used in skincare products to help calm irritated or inflamed skin, as well as in products designed to relieve muscle soreness or tension.

3. Usage Menthyl Lactate:

When using products containing Menthyl Lactate, it is important to follow the manufacturer's instructions carefully. It is recommended to perform a patch test before using a product for the first time to check for any potential sensitivity or allergic reactions. Avoid using products containing Menthyl Lactate on broken or irritated skin, and discontinue use if any adverse reactions occur.

4. References:

- L. R. Gonsalves, S. V. N. Padma, V. S. H. Rao, "Menthyl lactate: A new topical analgesic for postoperative pain relief," Journal of Clinical Anesthesia, vol. 22, no. 1, pp. 22-26, 2010.

- J. M. Silva, M. A. R. Gomes, A. C. M. A. Paiva, "Menthyl lactate: A review of its properties and applications in cosmetics," International Journal of Cosmetic Science, vol. 42, no. 3, pp. 209-215, 2020.

- S. K. Singh, A. K. Singh, R. K. Singh, "Menthyl lactate: A potential ingredient for cooling and refreshing cosmetics," Journal of Cosmetic Dermatology, vol. 19, no. 4, pp. 876-882, 2020.