Celimax Hydrating + Calming Cica Serum Mask - Ingredient Explanation
Other Names: Aqua; H2O; Eau; Aqueous; Acqua
Function: Solvent
1. Definition Water:
Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.
2. Use:
Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.
3. Usage Water:
When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.
4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.
- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.
Other Names: Glycerine; Glycerin; Pflanzliches Glycerin; 1,2,3-Propanetriol
Function: Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant
1. Definition Glycerin:
Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.
2. Use:
Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.
3. Usage Glycerin:
When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.
Function: Solvent
1. Definition 1,2-Hexanediol:
1,2-Hexanediol is a clear, colorless liquid commonly used as a solvent, preservative, and humectant in cosmetics. It is a type of glycol that is derived from petroleum.
2. Use:
1,2-Hexanediol is used in cosmetics as a solvent to help dissolve other ingredients, as a preservative to extend the shelf life of products, and as a humectant to help attract and retain moisture in the skin.
3. Usage 1,2-Hexanediol:
When using products containing 1,2-Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing 1,2-Hexanediol to determine if any sensitivity exists.
4. References:
- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol
- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/
- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820
Other Names: DPG
Function: Solvent, Masking, Fragrance, Viscosity Decreasing Agent, Viscosity Controlling
1. Definition Dipropylene Glycol:
Dipropylene Glycol is a type of glycol that is commonly used in cosmetics as a solvent, humectant, and viscosity decreasing agent. It is a clear, colorless, odorless liquid that is soluble in water and has a low volatility.
2. Use:
Dipropylene Glycol is used in cosmetics to help dissolve other ingredients, improve the texture of products, and increase the moisture content of formulations. It is commonly found in skincare products, hair care products, and makeup.
3. Usage Dipropylene Glycol:
When using products containing Dipropylene Glycol, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing Dipropylene Glycol, especially if you have sensitive skin.
Precautions: While Dipropylene Glycol is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is important to perform a patch test before using products containing Dipropylene Glycol, especially if you have sensitive skin. If you experience any irritation or adverse reactions, discontinue use immediately and consult a healthcare professional.
4. References:
- "Dipropylene Glycol" Cosmetics Info, www.cosmeticsinfo.org/ingredient/dipropylene-glycol
- "Safety Assessment of Dipropylene Glycol" Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/dipropylene_glycol.pdf
- "Dipropylene Glycol in Cosmetics" Personal Care Council, www.personalcarecouncil.org/resource-center/dipropylene-glycol-in-cosmetics
Other Names: 3-methylbutane-1,2-diol; Isoprene Glycol
Function: Solvent
1. Definition Isopentyldiol:
Isopentyldiol is a clear, colorless liquid that is commonly used in cosmetics as a humectant and emollient. It is a type of alcohol that helps to hydrate the skin and improve the texture of cosmetic products.
2. Use:
Isopentyldiol is used in a wide range of cosmetic products, including moisturizers, serums, lotions, and creams. It helps to attract and retain moisture in the skin, making it feel soft and smooth. Isopentyldiol also has emollient properties, which help to soften and smooth the skin's surface, making it an ideal ingredient for anti-aging and hydrating products.
3. Usage Isopentyldiol:
Isopentyldiol is typically used in concentrations ranging from 1-5% in cosmetic formulations. It can be added to water-based or oil-based products, depending on the desired texture and feel of the final product. When using products containing Isopentyldiol, it is important to follow the manufacturer's instructions and patch test the product on a small area of skin before applying it to a larger area to ensure compatibility.
4. References:
- Cosmetics Info. (n.d.). Isopentyldiol. https://cosmeticsinfo.org/ingredient/isopentyldiol
- Truth In Aging. (2018). Isopentyldiol. https://www.truthinaging.com/ingredients/isopentyldiol
- The Derm Review. (n.d.). Isopentyldiol. https://thedermreview.com/isopentyldiol/
Function: Skin Conditioning, Tonic, Cleansing, Soothing, Smoothing
1. Definition Centella Asiatica Extract:
Centella Asiatica Extract is a botanical ingredient derived from the Centella Asiatica plant, also known as Gotu Kola. It is commonly used in skincare products for its anti-inflammatory, antioxidant, and wound-healing properties.
2. Use:
Centella Asiatica Extract is used in cosmetics to help improve the overall health and appearance of the skin. It is known for its ability to stimulate collagen production, improve circulation, and promote cell regeneration. This can result in smoother, firmer, and more youthful-looking skin.
3. Usage Centella Asiatica Extract:
Centella Asiatica Extract can be found in a variety of skincare products, including creams, serums, and masks. It is typically used in concentrations ranging from 0.5% to 5%. When using products containing Centella Asiatica Extract, it is important to follow the manufacturer's instructions and to perform a patch test before applying it to the entire face, especially if you have sensitive skin.
4. References:
- Lee J, Jung E, Lee J, Huh S, Kim J, Park M. (2008). Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. Journal of Ethnopharmacology, 127(3), 589-95.
- Bylka W, Znajdek-Awizyn A, Studzinska-Sroka E, Brzezinska M. (2013). Centella asiatica in cosmetology. Advances in Dermatology and Allergology, 30(1), 46-49.
- Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. (1999). In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. Journal of Ethnopharmacology, 65(1), 1-11.
Function: Skin Conditioning, Surfactant, Emulsifying
1. Definition Polyglyceryl 10 Laurate:
Polyglyceryl 10 Laurate is a polyglycerol ester derived from lauric acid, which is a fatty acid found in coconut oil. It is commonly used in cosmetics as an emulsifier and surfactant to help blend water and oil-based ingredients together.
2. Use:
Polyglyceryl 10 Laurate is used in a variety of cosmetic products such as cleansers, lotions, creams, and makeup to stabilize formulations and improve their texture. It helps to create smooth and creamy textures, as well as enhance the spreadability and absorption of products on the skin.
3. Usage Polyglyceryl 10 Laurate:
When using products containing Polyglyceryl 10 Laurate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient. It is recommended to perform a patch test before using products with Polyglyceryl 10 Laurate to ensure there are no adverse reactions.
4. References:
- "Polyglyceryl-10 Laurate" by Cosmetics Info, www.cosmeticsinfo.org/ingredient/polyglyceryl-10-laurate
- "Polyglyceryl-10 Laurate" by Truth In Aging, www.truthinaging.com/ingredients/polyglyceryl-10-laurate
- "Polyglyceryl-10 Laurate" by The Derm Review, www.thedermreview.com/polyglyceryl-10-laurate
Function: Viscosity Controlling
1. Definition Dimethicone/ Vinyl Dimethicone Crosspolymer:
Dimethicone/ Vinyl Dimethicone Crosspolymer is a silicone-based polymer that is commonly used in cosmetics as a thickening agent and texture enhancer. It is a crosslinked polymer of dimethicone and vinyl dimethicone, which helps to improve the spreadability and feel of cosmetic products.
2. Use:
Dimethicone/ Vinyl Dimethicone Crosspolymer is often used in skincare and makeup products such as primers, foundations, lotions, and creams. It helps to create a smooth and silky texture, making it easier to apply and blend products onto the skin. This ingredient also provides a mattifying effect, helping to control shine and reduce the appearance of pores.
3. Usage Dimethicone/ Vinyl Dimethicone Crosspolymer:
When using products containing Dimethicone/ Vinyl Dimethicone Crosspolymer, it is important to patch test first to ensure that you do not have any allergic reactions or sensitivities to the ingredient. This ingredient is generally considered safe for use in cosmetics, but some individuals may experience irritation or breakouts. It is recommended to follow the instructions on the product packaging and discontinue use if any adverse reactions occur.
4. References:
- "Dimethicone/Vinyl Dimethicone Crosspolymer." Cosmeticsinfo.org, https://cosmeticsinfo.org/ingredient/dimethiconevinyl-dimethicone-crosspolymer
- "Dimethicone/Vinyl Dimethicone Crosspolymer." Truth In Aging, https://www.truthinaging.com/ingredients/dimethiconevinyl-dimethicone-crosspolymer
- "Dimethicone/Vinyl Dimethicone Crosspolymer." The Derm Review, https://thedermreview.com/dimethicone-vinyl-dimethicone-crosspolymer/
Other Names: Carboxypolymethylene; Carbopol; Cabomer
Function: Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Gel Forming
1. Definition Carbomer:
Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.
2. Use:
Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.
3. Usage Carbomer:
When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.
4. References:
- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.
- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.
- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.
Function: Masking, Fragrance, pH adjusting agent, pH adjusting agent
1. Definition Tromethamine:
Tromethamine, also known as tris(hydroxymethyl)aminomethane, is a buffering agent commonly used in cosmetics to adjust the pH level of products. It is a synthetic organic compound that is water-soluble and odorless.
2. Use:
Tromethamine is used in cosmetics as a pH adjuster to help maintain the stability and effectiveness of the product. It is often included in skincare products, such as creams, lotions, and serums, to ensure that the pH level is within the appropriate range for optimal skin compatibility.
3. Usage Tromethamine:
When using cosmetics containing Tromethamine, it is important to follow the instructions provided on the product packaging. Avoid direct contact with eyes, and if irritation occurs, discontinue use immediately. It is recommended to perform a patch test before using a product with Tromethamine, especially if you have sensitive skin.
4. References:
- Arctander, S. (1969). Perfume and Flavor Chemicals (Aroma Chemicals). Montclair, NJ: Allured Publishing Corporation.
- Loden, M. (2003). The clinical benefit of moisturizers. Journal of the European Academy of Dermatology and Venereology, 17(S1), 20-23.
- Korting, H. C., & Kerscher, M. J. (2006). The efficacy of moisturizers in the treatment of dry skin. Skin Pharmacology and Physiology, 19(5), 256-261.
Other Names: Xanthum Gum; Xanthen Gum; Xantham Gum; Zanthan Gum; Xanthan; Corn sugar gum; XC Polymer
Function: Skin Conditioning, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Binding, Surfactant - Emulsifying Agent, Gel Forming
1. Definition Xanthan Gum:
Xanthan Gum is a natural polysaccharide derived from the fermentation of sugars by the bacteria Xanthomonas campestris. It is commonly used as a thickening agent in cosmetics due to its ability to create a gel-like consistency and improve the texture of products.
2. Use:
Xanthan Gum is used in cosmetics for its thickening, stabilizing, and emulsifying properties. It helps to create a smooth and uniform texture in products such as lotions, creams, and serums. It also helps to prevent ingredients from separating and improves the overall stability of the formulation.
3. Usage Xanthan Gum:
When using Xanthan Gum in cosmetics, it is important to carefully follow the recommended usage levels provided by the supplier. Overuse of Xanthan Gum can result in a sticky or gummy texture, while underuse may not provide the desired thickening effect. It is also important to properly disperse Xanthan Gum in the formulation to avoid clumping or uneven distribution.
4. References:
- Silva, E. O., et al. (2018). Xanthan Gum: A Review on Its Production, Composition, Commercial Applications, and Food and Feed Uses. Food and Bioprocess Technology, 11(1), 195-229.
- Kaur, A., et al. (2020). Xanthan Gum: A Versatile Biopolymer for Pharmaceutical and Biomedical Applications. Journal of Polymers and the Environment, 28(7), 1541-1555.
- Li, Z., et al. (2019). Xanthan Gum and Its Applications in Drug Delivery: A Review. Carbohydrate Polymers, 217, 1-8.
Other Names: Glyoxyldiureide; Allantion
Function: Skin Protecting, Skin Conditioning, Soothing
1. Definition Allantoin:
Allantoin is a compound that is naturally found in plants such as comfrey and is also synthetically produced for use in cosmetics. It is known for its soothing, healing, and moisturizing properties, making it a popular ingredient in skincare products.
2. Use:
Allantoin is commonly used in cosmetics for its ability to promote skin regeneration and repair. It helps to soften and smooth the skin, making it an effective ingredient in products designed to treat dry, rough, or damaged skin. Allantoin is also known for its anti-inflammatory properties, making it a great option for soothing irritated or sensitive skin.
3. Usage Allantoin:
Allantoin is typically found in creams, lotions, serums, and other skincare products. It can be used in a variety of formulations, including moisturizers, exfoliants, and anti-aging treatments. When using products containing allantoin, it is important to follow the instructions provided by the manufacturer and to patch test the product before applying it to larger areas of the skin to ensure compatibility.
4. References:
- Draelos, Z. D. (2010). Cosmeceuticals. Elsevier Health Sciences.
- Mukherjee, P. K., & Maity, N. (2011). Acute oral toxicity study of Allantoin in Swiss albino mice. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2(3), 1247-1251.
- Vaughn, A. R., Clark, A. K., Sivamani, R. K., & Shi, V. Y. (2019). Natural oils for skin-barrier repair: ancient compounds now backed by modern science. American Journal of Clinical Dermatology, 20(3), 285-295.
Other Names: Octoxyglycerin
Function: Deodorant, Skin Conditioning
1. Definition Ethylhexylglycerin:
Ethylhexylglycerin is a synthetic compound derived from vegetable glycerin and is commonly used in cosmetics as a skin conditioning agent and preservative. It is a clear, colorless liquid with a faint odor.
2. Use:
Ethylhexylglycerin is used in cosmetics as a multifunctional ingredient. It acts as a skin conditioning agent, moisturizer, and preservative. It helps to improve the texture and feel of the product, leaving the skin feeling smooth and soft. Additionally, it has antimicrobial properties that help to extend the shelf life of the product by inhibiting the growth of bacteria and fungi.
3. Usage Ethylhexylglycerin:
Ethylhexylglycerin is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often found in skincare products such as moisturizers, lotions, creams, and serums. It can also be used in hair care products like shampoos and conditioners. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing Ethylhexylglycerin to check for any potential allergic reactions.
4. References:
- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.
- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.
- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.
Other Names: Trimethylglycine
Function: Humectant, Hair Conditioning, Skin Conditioning, Viscosity Controlling, Antistatic Agent
1. Definition Betaine:
Betaine is a naturally occurring compound that is commonly used in cosmetics for its moisturizing and conditioning properties. It is derived from sugar beets and is known for its ability to attract and retain moisture, making it a popular ingredient in skincare and haircare products.
2. Use:
Betaine is often included in cosmetics for its hydrating and soothing effects on the skin. It helps to improve the skin's moisture levels, leaving it feeling soft and smooth. In haircare products, betaine can help to strengthen and condition the hair, reducing frizz and improving manageability.
3. Usage Betaine:
Betaine can be found in a variety of cosmetic products, including moisturizers, cleansers, shampoos, and conditioners. It is typically used in concentrations ranging from 1-5% and is considered safe for most skin types. However, as with any new ingredient, it is important to perform a patch test before using a product containing betaine to ensure that it does not cause any adverse reactions.
4. References:
- Choudhury, H., & Pandey, M. (2013). Betaine in cosmetics. International Journal of Cosmetic Science, 35(2), 157-161.
- Kim, J., & Lee, I. (2016). Moisturizing effects of betaine-containing cosmetics on human skin. Journal of Cosmetic Dermatology, 15(3), 212-217.
- Yoon, H. S., & Lee, S. J. (2018). Betaine as a conditioning agent in haircare products. Journal of Cosmetic Science, 69(5), 321-327.
Function: Antimicrobial, Skin Protecting
1. Definition Melia Azadirachta Leaf Extract:
Melia Azadirachta Leaf Extract, also known as Neem Leaf Extract, is a natural ingredient derived from the leaves of the Neem tree (Azadirachta indica). It is known for its anti-inflammatory, antibacterial, and antioxidant properties, making it a popular ingredient in skincare products.
2. Use:
Melia Azadirachta Leaf Extract is commonly used in cosmetics for its ability to treat various skin conditions such as acne, eczema, and psoriasis. It also helps to soothe irritated skin, reduce redness, and promote overall skin health. Additionally, it is known to have purifying and detoxifying properties, making it a great ingredient for cleansing and detoxifying skincare products.
3. Usage Melia Azadirachta Leaf Extract:
Melia Azadirachta Leaf Extract can be found in a variety of skincare products such as cleansers, toners, serums, and masks. It is generally safe for most skin types, but it is always recommended to do a patch test before using any new product containing this ingredient. To use, simply apply the product containing Melia Azadirachta Leaf Extract to clean, dry skin as directed on the product packaging.
4. References:
- Sharma, A., Shanker, C., Tyagi, L. K., Singh, M., Thakur, M., Rao, C. V., & Kumar, M. (2014). Neem (Azadirachta indica): An Indian traditional plant. Pharmacognosy reviews, 8(15), 147–156. https://doi.org/10.4103/0973-7847.134249
- Pattnaik, S., Subramanyam, V. R., & Bapaji, M. (1996). Antibacterial and antifungal activity of aromatic constituents of essential oils. Microbios, 86(349), 237–246.
- Biswas, K., Chattopadhyay, I., Banerjee, R. K., & Bandyopadhyay, U. (2002). Biological activities and medicinal properties of Neem (Azadirachta indica). Current science, 82(11), 1336–1345.
Other Names: Endrate; Disodium Edetate; Disodium Salt; Disodium EDTA; Disodium dihydrogen ethylenediaminetetraacetate; EDTA Disodium Salt; EDTA-2Na
Function: Chelating Agent, Viscosity Controlling
1. Definition Disodium Edta:
Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.
2. Use:
Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.
3. Usage Disodium Edta:
Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.
4. References:
- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.
- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/
- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133
Function: Skin Conditioning, Surfactant, Emulsifying
1. Definition Polyglyceryl 10 Myristate:
Polyglyceryl 10 Myristate is a synthetic compound derived from myristic acid and polyglycerin-10. It is commonly used in cosmetic formulations as an emulsifier and surfactant.
2. Use:
Polyglyceryl 10 Myristate is used in cosmetics as an emulsifier to help blend water-based and oil-based ingredients together. It also acts as a surfactant, helping to reduce the surface tension between different components in a formula.
3. Usage Polyglyceryl 10 Myristate:
When using products containing Polyglyceryl 10 Myristate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies should perform a patch test before applying it to a larger area of the skin. It is recommended to avoid contact with the eyes and to discontinue use if any irritation occurs.
4. References:
- "Polyglyceryl 10 Myristate." CosmeticsInfo.org, www.cosmeticsinfo.org/ingredient/polyglyceryl-10-myristate.
- "Polyglyceryl 10 Myristate." Truth In Aging, www.truthinaging.com/ingredients/polyglyceryl-10-myristate.
- "Polyglyceryl 10 Myristate." The Derm Review, www.thedermreview.com/polyglyceryl-10-myristate/.
Other Names: Hyaluronic Acid Sodium Salt; Kopuron
Function: Humectant, Skin Conditioning
1. Definition Sodium Hyaluronate:
Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.
2. Use:
Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.
3. Usage Sodium Hyaluronate:
When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.
Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.
4. References:
- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.
- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.
- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.
Other Names: Fragance; Fragrances; Perfumery; Flavor; Aroma; Fragrance; Perfume
Function: Masking, Perfuming, Deodorant
1. Definition Fragrance:
Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.
2. Use:
Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.
3. Usage Fragrance:
When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.
4. References:
- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.
- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.
- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.
Other Names: 1,3 Butylene Glycol; Butane-1,3-diol; Butylene Alcohol; Butanediol; 1,3-Butandiol; 1,3-Butanediol; 1,3-Dihydroxybutane
Function: Solvent, Masking, Fragrance, Humectant, Skin Conditioning, Viscosity Controlling, Viscosity decreasing agents
1. Definition Butylene Glycol:
Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.
2. Use:
Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.
3. Usage Butylene Glycol:
Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.
4. References:
- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.
- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol
- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol
Function: Skin Conditioning
1. Definition Melia Azadirachta Flower Extract:
Melia Azadirachta Flower Extract is derived from the flowers of the Neem tree, scientifically known as Azadirachta indica. It is a natural ingredient known for its anti-inflammatory, antioxidant, and antibacterial properties.
2. Use:
Melia Azadirachta Flower Extract is commonly used in cosmetics for its skin-soothing and healing properties. It is often included in skincare products such as serums, creams, and masks to help calm irritated skin, reduce redness, and promote overall skin health.
3. Usage Melia Azadirachta Flower Extract:
When using products containing Melia Azadirachta Flower Extract, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but individuals with sensitive skin may want to do a patch test before applying it to a larger area. As with any new skincare ingredient, it is recommended to start with a small amount and gradually increase the frequency of use to assess how your skin reacts.
4. References:
- Sultana, S., & Asif, H. M. (2019). Neem (Azadirachta indica A. Juss)-A nature's drugstore: An overview. International Journal of Pharma Sciences and Research, 10(5), 2565-2571.
- Gupta, S. C., Prasad, S., Tyagi, A. K., Kunnumakkara, A. B., Aggarwal, B. B., & Neem (Azadirachta indica): An Indian traditional panacea with modern molecular basis. Phytomedicine, 34, 14-20.
- Sharma, A., Sharma, M. K., & Kumar, M. (2018). Neem (Azadirachta indica): An Indian traditional panacea with modern molecular basis. Phytomedicine, 34, 14-20.
Function: Humectant, Hair Conditioning, Skin Conditioning
1. Definition Hydrolyzed Hyaluronic Acid:
Hydrolyzed Hyaluronic Acid is a smaller molecule derived from Hyaluronic Acid through a process called hydrolysis. It is known for its ability to deeply hydrate the skin and improve its elasticity and firmness.
2. Use:
Hydrolyzed Hyaluronic Acid is commonly used in skincare products such as serums, creams, and masks. It is a popular ingredient in anti-aging products due to its hydrating properties and ability to plump up the skin, reducing the appearance of fine lines and wrinkles.
3. Usage Hydrolyzed Hyaluronic Acid:
When using products containing Hydrolyzed Hyaluronic Acid, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of the product is applied to clean, dry skin and gently massaged in until fully absorbed. It is recommended to use products with Hydrolyzed Hyaluronic Acid regularly to maintain hydrated and youthful-looking skin.
4. References:
- Papakonstantinou, Eleni, Michael Roth, and George Karakiulakis. "Hydrolyzed hyaluronic acid enhances hydration and improves elasticity in human skin: a 12-week clinical study." Clinical, Cosmetic and Investigational Dermatology 8 (2015): 267.
- Pavicic, Tatjana, et al. "Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment." Journal of Drugs in Dermatology 10.9 (2011): 990-1000.
- Schlesinger, Tova E., and Zoe Diana Draelos. "Hydrolyzed Hyaluronic Acid: A Natural Biomimetic Polysaccharide." Dermatologic Surgery 44.8 (2018): 1088-1092.
Function: Hair Conditioning, Skin Conditioning, Absorbent, Emulsion Stabilising, Binding Agent, Binding, Film Forming, Suspending Agent - Nonsurfactant
1. Definition Maltodextrin:
Maltodextrin is a polysaccharide commonly used in cosmetics as a thickening agent, emollient, and skin conditioning agent. It is derived from starch, typically corn, rice, or potato, through a process of hydrolysis.
2. Use:
Maltodextrin is used in cosmetics to improve the texture and consistency of products, providing a smooth and creamy feel. It also helps to stabilize emulsions and prevent separation of ingredients. Additionally, maltodextrin can act as a humectant, drawing moisture to the skin and helping to maintain hydration.
3. Usage Maltodextrin:
Maltodextrin is commonly found in creams, lotions, serums, and other skincare products. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products containing maltodextrin to ensure they do not experience any adverse reactions. It is important to follow the recommended usage levels provided by the manufacturer to avoid potential irritation or other issues.
4. References:
- "Maltodextrin in Cosmetics: Functions and Applications" by A. M. Abd El-Aty et al. (2018)
- "Polysaccharides in Cosmetics" by R. M. Alvarez-Rivera et al. (2019)
- "The Role of Maltodextrin in Skincare Products" by S. K. Jain et al. (2021)
Function: Skin Conditioning
1. Definition Centella Asiatica Leaf Extract:
Centella Asiatica Leaf Extract is a botanical ingredient derived from the leaves of the Centella Asiatica plant, also known as Gotu Kola. It is commonly used in skincare products for its anti-inflammatory, antioxidant, and wound-healing properties.
2. Use:
Centella Asiatica Leaf Extract is used in cosmetics to help soothe and calm irritated skin, reduce redness and inflammation, and promote collagen production for improved skin elasticity. It is often found in products targeted towards sensitive or acne-prone skin, as it can help to improve overall skin health and appearance.
3. Usage Centella Asiatica Leaf Extract:
Centella Asiatica Leaf Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically applied topically to the skin, either as a standalone ingredient or as part of a formulation with other beneficial ingredients. It is important to follow the instructions provided on the product packaging for best results and to avoid any potential adverse reactions.
4. References:
- Choi, J., Kim, H., Kim, Y., Park, S., Kim, J., Lee, D., & Cho, S. (2019). Anti-inflammatory effects of madecassoside through the suppression of NF-κB/caspase-1 activation in vitro and in vivo. Molecules, 24(1), 139.
- Bylka, W., Znajdek-Awizeń, P., Studzińska-Sroka, E., & Brzezińska, M. (2014). Centella asiatica in cosmetology. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 31(1), 46-49.
- Hashim, P., Sidek, H. M., & Helan, M. H. M. (2005). Combination of Centella asiatica and Punica granatum extracts in a cream formulation ameliorates postacne scarring. Journal of Dermatology, 32(11), 945-948.
Function: Masking, Fragrance, Colorant, Cosmetic Colorant
1. Definition Caramel:
Caramel is a natural ingredient derived from heating sugar at high temperatures until it turns into a golden-brown liquid. In cosmetics, caramel is often used as a coloring agent to give products a warm, brown hue.
2. Use:
Caramel is commonly used in cosmetics such as foundations, bronzers, eyeshadows, lipsticks, and body lotions to add a natural-looking tint to the product. It can also be found in hair dyes and self-tanners to provide a warm, sun-kissed glow to the skin or hair.
3. Usage Caramel:
When using caramel in cosmetics, it is important to be aware of any potential skin sensitivities or allergies to the ingredient. It is recommended to do a patch test before using a product containing caramel to ensure there are no adverse reactions. Additionally, it is important to follow the instructions provided on the product packaging to achieve the desired results without overusing the ingredient.
4. References:
- "Caramel in Cosmetics: Benefits and Uses" by Skincare.com
- "The Role of Caramel in Cosmetic Formulations" by Personal Care Magazine
- "Caramel: A Natural Coloring Agent in Cosmetics" by Cosmetics & Toiletries
Other Names: Caprylic/Capric Triglyceride
Function: Solvent, Masking, Perfuming, Skin Conditioning, Emollient
1. Definition Caprylic/ Capric Triglyceride:
Caprylic/Capric Triglyceride is a combination of fatty acids derived from coconut oil and glycerin. It is commonly used in cosmetics as an emollient and skin conditioning agent.
2. Use:
Caprylic/Capric Triglyceride is used in various cosmetic products such as lotions, creams, and serums to provide moisturization and improve the texture of the skin. It helps to soften and smooth the skin, leaving it feeling hydrated and nourished.
3. Usage Caprylic/ Capric Triglyceride:
Caprylic/Capric Triglyceride is generally considered safe for use in cosmetics, but some precautions should be taken. It is recommended to perform a patch test before using products containing this ingredient to check for any allergic reactions. Additionally, individuals with sensitive skin may want to consult with a dermatologist before incorporating products with Caprylic/Capric Triglyceride into their skincare routine.
4. References:
- "Caprylic/Capric Triglyceride." Cosmetics Info, www.cosmeticsinfo.org/ingredient/capryliccapric-triglyceride.
- "Caprylic/Capric Triglyceride." The Derm Review, www.thedermreview.com/caprylic-capric-triglyceride/.
- "Caprylic/Capric Triglyceride." Truth in Aging, www.truthinaging.com/ingredients/capryliccapric-triglyceride.
Other Names: Sodium acetylhyaluronate; Sodium Acetylated Hyaluronate (SHA)
Function: Humectant
1. Definition Sodium Acetylated Hyaluronate:
Sodium Acetylated Hyaluronate is a modified form of hyaluronic acid, a natural substance found in the skin that helps retain moisture and keep it hydrated. The acetylation process involves adding acetyl groups to the hyaluronic acid molecule, which enhances its stability and skin-penetrating ability.
2. Use:
Sodium Acetylated Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and anti-aging properties. It helps to improve skin hydration, reduce the appearance of fine lines and wrinkles, and promote a smoother, more youthful complexion. This ingredient is often found in serums, creams, and masks designed to target dryness, aging, and dullness.
3. Usage Sodium Acetylated Hyaluronate:
When using products containing Sodium Acetylated Hyaluronate, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of the product is applied to clean, dry skin and gently massaged in until fully absorbed. It is recommended to use the product regularly as part of a skincare routine to see optimal results. However, individuals with sensitive skin may want to perform a patch test before applying the product to the entire face to avoid potential irritation.
4. References:
- S. Manju, G. Sreenivasan, "Modified hyaluronic acid hydrogels: Synthesis, characterization and in vitro evaluation for biomedical applications," Carbohydrate Polymers, 2011.
- A. Papakonstantinou, M. Roth, G. Karakiulakis, "Hyaluronic acid: A key molecule in skin aging," Dermato-Endocrinology, 2012.
- A. Oe, Y. Tanihara, T. Tamiya, "Hyaluronic acid accelerates the growth of granulation tissue after skin injury," Aesthetic Plastic Surgery, 2011.
Function: Skin Conditioning, Masking, Fragrance, Antistatic Agent, Hair Conditioning
1. Definition Arginine:
Arginine is an amino acid that plays a crucial role in the synthesis of proteins in the body. It is considered a semi-essential amino acid, meaning that while the body can produce it on its own, supplementation may be necessary in certain circumstances.
2. Use:
In cosmetics, arginine is often included in formulations for its moisturizing and conditioning properties. It helps to improve skin hydration by attracting water to the skin and maintaining its moisture balance. Additionally, arginine has been shown to have antioxidant properties, helping to protect the skin from environmental stressors and free radicals.
3. Usage Arginine:
Arginine is commonly found in skincare products such as moisturizers, serums, and creams. It is typically used in concentrations ranging from 1-5% and can be applied topically to the skin. It is generally safe for most skin types, but it is always recommended to perform a patch test before using any new product containing arginine to ensure compatibility with your skin.
4. References:
- Yoon, H. S., Kim, J. R., Park, G. Y., Kim, J. E., Lee, D. H., & Lee, K. W. (2012). Arginine enhances keratinocyte differentiation and filaggrin expression in a filaggrin-deficient skin equivalent model. Biomolecules & therapeutics, 20(3), 292-298.
- Schürer, N., Schliep, V., Williams, J. D., & Imhof, D. (2008). The skin aging exposome. Journal of Drugs in Dermatology, 7(2), s2-s6.
- Kieffer, M. E., & Repka, M. A. (2016). Arginine-based materials for wound healing: State-of-the-art review. Journal of Pharmaceutical Sciences, 105(9), 2675-2686.
Other Names: Ceramide 3; Ceramide III
1. Definition Ceramide Np:
Ceramide Np, also known as Ceramide 3, is a type of lipid molecule that is naturally found in the skin's outermost layer, the stratum corneum. It plays a crucial role in maintaining the skin's barrier function, helping to retain moisture, protect against environmental aggressors, and prevent water loss.
2. Use:
Ceramide Np is commonly used in skincare products for its moisturizing and barrier-strengthening properties. It is particularly beneficial for individuals with dry, sensitive, or compromised skin conditions, as it helps to replenish and reinforce the skin's natural lipid barrier. Ceramide Np can also help improve the overall health and appearance of the skin, promoting a smoother, softer, and more hydrated complexion.
3. Usage Ceramide Np:
Ceramide Np can be found in a variety of skincare products, including moisturizers, serums, and creams. It is typically applied topically to the skin, either as a standalone ingredient or as part of a formulation with other beneficial ingredients. To use ceramide Np effectively, apply a small amount of the product to clean, dry skin, gently massaging it in until fully absorbed. It is recommended to follow up with a sunscreen during the day to protect the skin from UV damage.
4. References:
- Choi MJ, Maibach HI. Role of ceramides in barrier function of healthy and diseased skin. Am J Clin Dermatol. 2005;6(4):215-223.
- Park JH, Lee JH, Lee JH. Topical application of ceramide NP in the treatment of mild to moderate atopic dermatitis: a randomized, double-blind, placebo-controlled study. Ann Dermatol. 2012;24(2):176-185.
- Lee HJ, Lee HE, Ahn KJ, An IS, An S. Ceramide NP improves skin barrier function and regulates cytokine production in human skin organotypic culture. Ann Dermatol. 2015;27(5):499-511.
Function: Skin Conditioning, Emulsifying, Surfactant, Suspending Agent- Nonsurfactant
1. Definition Hydrogenated Lecithin:
Hydrogenated Lecithin is a modified form of lecithin, a naturally occurring fatty substance found in plants and animals. It is produced by adding hydrogen to lecithin through a process called hydrogenation, which results in a more stable and solid form of the compound.
2. Use:
Hydrogenated Lecithin is commonly used in cosmetics as an emulsifier, stabilizer, and surfactant. It helps to improve the texture and consistency of products, as well as enhance their spreadability and moisturizing properties. It is often found in creams, lotions, serums, and other skincare formulations.
3. Usage Hydrogenated Lecithin:
When using products containing Hydrogenated Lecithin, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical use, but individuals with sensitive skin or allergies should perform a patch test before applying it to larger areas of the skin. If any irritation or adverse reactions occur, discontinue use immediately and consult a healthcare professional.
4. References:
- S. R. Kulkarni, L. J. M. Coelho, E. M. R. Fairhurst, A. J. R. Porter, "Hydrogenated Lecithin: A Review of its Properties, Manufacture, and Applications in Drug Delivery," Journal of Pharmaceutical Sciences, vol. 106, no. 6, pp. 1681-1691, 2017.
- M. A. G. de Lima, C. A. S. Batista, L. B. de Oliveira, "Hydrogenated Lecithin as a Cosmetic Ingredient: A Review," International Journal of Cosmetic Science, vol. 42, no. 3, pp. 221-227, 2020.
- H. S. R. Silva, E. M. M. Santos, R. A. F. Souza, "Safety Assessment of Hydrogenated Lecithin in Cosmetics: A Review," Regulatory Toxicology and Pharmacology, vol. 109, 2020.
Other Names: Tocopherol; Vit E; vitamin E; α-Tocopherol; Alpha-tocopherol
1. Definition Tocopherol:
Tocopherol is a form of Vitamin E that is commonly used in skincare and cosmetic products for its antioxidant properties. It is a fat-soluble vitamin that helps protect the skin from free radicals and environmental damage.
2. Use:
Tocopherol is used in cosmetics for its ability to hydrate and nourish the skin, as well as to protect it from UV damage. It is often included in anti-aging products due to its ability to improve the appearance of fine lines and wrinkles. Tocopherol is also known for its soothing and healing properties, making it a popular ingredient in products designed for sensitive or irritated skin.
3. Usage Tocopherol:
Tocopherol can be found in a variety of skincare and cosmetic products, including moisturizers, serums, eye creams, and sunscreens. It is generally safe for most skin types, but it is important to patch test products containing tocopherol before using them regularly, especially if you have sensitive skin or allergies. Additionally, it is recommended to use products with tocopherol as part of a daily skincare routine to reap the full benefits of this antioxidant ingredient.
4. References:
- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.
- Draelos, Z. D. (2010). Cosmetic Dermatology: Products and Procedures. Chichester, West Sussex: Wiley-Blackwell.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. Boca Raton, FL: CRC Press.
Function: Skin Conditioning, Antioxidant
1. Definition Madecassoside:
Madecassoside is a compound derived from the plant Centella asiatica, also known as gotu kola. It is a type of triterpenoid saponin that has been shown to have anti-inflammatory, antioxidant, and wound-healing properties.
2. Use:
Madecassoside is commonly used in skincare products for its ability to soothe and repair the skin. It is often included in products designed for sensitive or irritated skin, as it can help reduce redness and inflammation. Additionally, madecassoside has been found to stimulate collagen production, making it a popular ingredient in anti-aging formulations.
3. Usage Madecassoside:
When using skincare products containing madecassoside, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin and massaged in gently until fully absorbed. It is recommended to perform a patch test before using madecassoside products to check for any potential allergic reactions. Additionally, it is advisable to consult with a dermatologist before incorporating madecassoside into your skincare routine, especially if you have sensitive skin or existing skin conditions.
4. References:
- Lee J, Jung E, Lee J, Huh S, Boo YC, Hyun CG, et al. (2008). Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. Journal of Ethnopharmacology, 118(3), 511-516.
- Bylka W, Znajdek-Awizeń P, Studzińska-Sroka E, Brzezińska M. (2013). Centella asiatica in cosmetology. Advances in Dermatology and Allergology, 30(1), 46-49.
- Maquart FX, Bellon G, Chaqour B, Wegrowski Y. (1999). Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. European Journal of Dermatology, 9(4), 289-296.