Cipher Ctrl Z

1. Definition Isodecyl Neopentanoate:

Isodecyl Neopentanoate is a synthetic ester derived from neopentanoic acid and isodecyl alcohol. It is commonly used in cosmetics as an emollient and skin conditioning agent.

2. Use:

Isodecyl Neopentanoate is primarily used in skincare products such as lotions, creams, and serums. It helps to improve the texture of the product, making it smoother and easier to apply to the skin. Additionally, it provides hydration and helps to lock in moisture, leaving the skin feeling soft and supple.

3. Usage Isodecyl Neopentanoate:

Isodecyl Neopentanoate is typically used in concentrations ranging from 1-10% in cosmetic formulations. It is safe for use on all skin types, including sensitive skin. However, as with any new ingredient, it is recommended to perform a patch test before using products containing Isodecyl Neopentanoate to ensure compatibility with your skin.

Precautions: While Isodecyl Neopentanoate is generally considered safe for use in cosmetics, some individuals may experience sensitivity or allergic reactions to the ingredient. If irritation occurs, discontinue use and consult a healthcare professional. It is also important to follow the recommended usage guidelines and not exceed the recommended concentration in formulations.

4. References:

- "Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of Isodecyl Neopentanoate." International Journal of Toxicology, 2002.

- Personal Care Products Council. "Isodecyl Neopentanoate." Accessed from https://www.personalcarecouncil.org/ingredient-isodecyl-neopentanoate/

- "Isodecyl Neopentanoate." Cosmetics Info. Accessed from https://cosmeticsinfo.org/ingredient/isodecyl-neopentanoate

1. Definition Glyceryl Stearate:

Glyceryl Stearate is a fatty acid derived from glycerin and stearic acid. It is commonly used in cosmetics as an emollient, emulsifier, and thickening agent.

2. Use:

Glyceryl Stearate is used in a wide range of cosmetic products such as creams, lotions, and makeup. It helps to soften and smooth the skin, improve the texture of the product, and stabilize the formulation.

3. Usage Glyceryl Stearate:

When using products containing Glyceryl Stearate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with Glyceryl Stearate, especially if you have sensitive skin.

4. References:

- "Glyceryl Stearate" by The Personal Care Products Council

- "Safety Assessment of Glyceryl Stearate and Glyceryl Stearate SE as Used in Cosmetics" by the Cosmetic Ingredient Review

- "Glyceryl Stearate" by Paula's Choice Skincare

1. Definition Niacinamide:

Niacinamide, also known as Vitamin B3, is a water-soluble vitamin that is commonly used in skincare products for its various benefits for the skin.

2. Use:

Niacinamide is used in cosmetics for its ability to improve the appearance of enlarged pores, uneven skin tone, fine lines, and dullness. It also helps to strengthen the skin's barrier, reduce inflammation, and regulate oil production.

3. Usage Niacinamide:

Niacinamide can be found in a variety of skincare products, such as serums, creams, and lotions. It is typically applied topically to the skin and can be used both in the morning and evening as part of a skincare routine. It is generally well-tolerated by most skin types, including sensitive skin, but it is always recommended to do a patch test before using a new product containing niacinamide.

Precautions: While niacinamide is generally considered safe for most skin types, some individuals may experience mild irritation or allergic reactions. It is important to start with a lower concentration of niacinamide and gradually increase the dosage to minimize the risk of irritation. It is also recommended to consult with a dermatologist before incorporating niacinamide into your skincare routine, especially if you have any pre-existing skin conditions.

4. References:

- Schagen, S. K., Zampeli, V. A., Makrantonaki, E., & Zouboulis, C. C. (2012). Discovering the link between nutrition and skin aging. Dermato-endocrinology, 4(3), 298-307.

- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery, 31(7), 860-865.

- Draelos, Z. D. (2005). The latest cosmeceutical approaches for anti-aging. Journal of Cosmetic Dermatology, 4(4), 273-278.

1. Definition Undecylenoyl Phenylalanine:

Undecylenoyl Phenylalanine is a synthetic amino acid derivative that is commonly used in cosmetics for its skin-lightening and brightening properties. It is often included in skincare products designed to target hyperpigmentation and uneven skin tone.

2. Use:

Undecylenoyl Phenylalanine works by inhibiting the production of melanin in the skin, which can help to reduce the appearance of dark spots and discoloration. It is typically found in serums, creams, and lotions that are formulated to improve skin tone and promote a more even complexion.

3. Usage Undecylenoyl Phenylalanine:

When using products containing Undecylenoyl Phenylalanine, it is important to follow the instructions provided by the manufacturer. It is recommended to apply the product to clean, dry skin and to use sunscreen during the day to protect the skin from further sun damage. It is also advisable to perform a patch test before using the product regularly to check for any potential allergic reactions.

4. References:

- Kim, S. Y., Kim, Y. J., & Kim, H. R. (2010). The inhibitory effect of undecylenoyl phenylalanine on melanogenesis. Archives of dermatological research, 302(6), 435-441.

- Lee, J. H., Kim, Y. J., & Kim, H. R. (2010). The effect of undecylenoyl phenylalanine on the expression of melanogenic proteins in melanocytes. Archives of dermatological research, 302(5), 371-376.

- Kim, S. Y., Kim, Y. J., & Kim, H. R. (2011). The effects of undecylenoyl phenylalanine on the expression of melanogenic proteins in B16F10 melanoma cells. Archives of dermatological research, 303(1), 47-53.

1. Definition Gluconolactone:

Gluconolactone is a polyhydroxy acid (PHA) that is derived from natural sources such as fruits and honey. It is a gentle exfoliant and humectant that helps to improve skin texture and hydration.

2. Use:

Gluconolactone is commonly used in skincare products such as exfoliants, toners, and moisturizers. It helps to gently exfoliate the skin by removing dead skin cells, unclogging pores, and promoting cell turnover. Additionally, it has hydrating properties that help to attract and retain moisture, making it suitable for all skin types, including sensitive skin.

3. Usage Gluconolactone:

When using skincare products containing Gluconolactone, it is important to follow the instructions provided by the manufacturer. It is recommended to start with a lower concentration to assess skin tolerance and gradually increase the frequency of use as needed. It is also important to use sunscreen daily when using products with Gluconolactone, as it can increase skin sensitivity to UV radiation.

4. References:

- Bhatia, A., & Maisuria, V. (2016). Polyhydroxy acids: A new generation of hydroxy acids. International Journal of Research in Cosmetic Science, 6(1), 1-5.

- Draelos, Z. D. (2005). The latest cosmeceutical approaches for anti-aging. Journal of Cosmetic Dermatology, 4(4), 273-278.

- Obagi, Z. E., & Obagi, S. (2003). Chemical peeling and aging skin. Journal of Geriatric Dermatology, 11(2), 67-71.

1. Definition Ethyl Oleate:

Ethyl Oleate is a fatty acid ester derived from oleic acid and ethanol. It is a clear, colorless liquid with a mild odor and is commonly used as a solvent in various cosmetic formulations.

2. Use:

Ethyl Oleate is primarily used in skincare products as an emollient and skin-conditioning agent. It helps to soften and smooth the skin, making it an ideal ingredient in moisturizers, lotions, and creams. It is also used in hair care products to improve the texture and manageability of the hair.

3. Usage Ethyl Oleate:

Ethyl Oleate should be used in cosmetic formulations at concentrations recommended by the manufacturer or formulator. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient. It is important to perform a patch test before using products containing Ethyl Oleate to ensure no adverse reactions occur. As with any cosmetic ingredient, it is recommended to consult with a dermatologist if you have any concerns about using products containing Ethyl Oleate.

4. References:

- Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of Oleic Acid, Lauric Acid, Palmitic Acid, Myristic Acid, and Stearic Acid. International Journal of Toxicology. 2001;20(Suppl 1):1-14.

- Personal Care Products Council. Oleic Acid and Oleate Esters. Accessed on: https://www.personalcarecouncil.org/oleic-acid-and-oleate-esters/

- U.S. Food and Drug Administration. Code of Federal Regulations Title 21. Accessed on: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.856

1. Definition Glycereth 26:

Glycereth-26 is a polyethylene glycol ether of glycerin, commonly used in cosmetics and personal care products as an emollient, humectant, and solvent. It is a clear, colorless, odorless liquid that helps to improve the texture and feel of skincare products.

2. Use:

Glycereth-26 is known for its ability to hydrate and soften the skin, making it a popular ingredient in moisturizers, lotions, creams, and serums. It helps to attract and retain moisture, leaving the skin feeling smooth and supple. Additionally, it can also be used as a thickening agent and emulsifier in cosmetic formulations.

3. Usage Glycereth 26:

Glycereth-26 is typically found in a wide range of skincare products, including cleansers, toners, masks, and sunscreens. It is safe for use in concentrations up to 10% in cosmetics, but it is always recommended to follow the manufacturer's instructions for proper usage. Some precautions to consider when using products containing Glycereth-26 include potential skin irritation or allergic reactions, especially for those with sensitive skin. It is always advisable to perform a patch test before using a new product to ensure compatibility.

4. References:

- International Journal of Toxicology. (2008). Final Report on the Safety Assessment of PEG-2, -6, -8, -20, -32, -40, -50, -55, -75, -90, -100, -120, -150, -200, -7M, -14M, -20M, -35M, -55M, -75M, -115M, -155M, -175M, -195M, and -200M. 27(S2), 1-82.

- Cosmetics Info. (n.d.). Glycereth-26. Retrieved from https://www.cosmeticsinfo.org/ingredient/glycereth-26

- Personal Care Council. (2019). Safety Assessment of PEG/PPG Esters and Their Ethoxylates as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/resource-center/safety-assessments/

1. Definition Glycerin:

Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.

2. Use:

Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.

3. Usage Glycerin:

When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.

1. Definition Opuntia Ficus-Indica Extract:

Opuntia Ficus-Indica Extract, also known as prickly pear extract, is derived from the Opuntia ficus-indica cactus plant. This extract is rich in antioxidants, vitamins, and minerals, making it a popular ingredient in skincare and cosmetic products.

2. Use:

Opuntia Ficus-Indica Extract is known for its hydrating, anti-inflammatory, and anti-aging properties. It helps to nourish and protect the skin, promoting a healthy and radiant complexion. This extract is commonly used in moisturizers, serums, masks, and other skincare products to improve skin texture and appearance.

3. Usage Opuntia Ficus-Indica Extract:

When using skincare products containing Opuntia Ficus-Indica Extract, it is important to follow the instructions provided on the product packaging. Apply the product to clean, dry skin and gently massage it in using upward motions. It is recommended to perform a patch test before using the product to check for any potential skin sensitivities or allergies. Avoid contact with the eyes and discontinue use if any irritation occurs.

4. References:

- Kim, S. Y., Kim, J., Kim, S. K., Lee, H. A., Kim, Y. J., & Lee, S. J. (2012). Opuntia ficus-indica attenuates neuronal injury in in vitro and in vivo models of cerebral ischemia. The Journal of Nutritional Biochemistry, 23(6), 630-636.

- Park, E. H., Kahng, J. H., & Paek, E. A. (2002). The antioxidant activity of Opuntia ficus-indica var. saboten. Journal of Ethnopharmacology, 79(3), 443-447.

- Feugang, J. M., Konarski, P., Zou, D., Stintzing, F. C., & Zou, C. (2006). Nutritional and medicinal use of Cactus pear (Opuntia spp.) cladodes and fruits. Frontiers in Bioscience, 11(1), 2574-2589.

1. Definition Salicylic Acid:

Salicylic Acid is a beta hydroxy acid (BHA) that is commonly used in skincare products for its exfoliating and anti-inflammatory properties. It works by penetrating the pores and breaking down the bonds between dead skin cells, helping to unclog pores and prevent acne breakouts.

2. Use:

Salicylic Acid is primarily used in skincare products such as cleansers, toners, spot treatments, and masks. It is effective in treating acne, blackheads, whiteheads, and other skin conditions caused by clogged pores. Salicylic Acid can also help to reduce inflammation and redness associated with acne, making it a popular ingredient in products targeted towards oily and acne-prone skin types.

3. Usage Salicylic Acid:

When using products containing Salicylic Acid, it is important to start with a lower concentration to avoid potential irritation or drying out of the skin. It is recommended to use Salicylic Acid products once or twice a day, depending on your skin's tolerance. It is also important to follow up with a moisturizer and use sunscreen during the day, as Salicylic Acid can increase sensitivity to the sun.

4. References:

- Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology, 3, 135–142. https://doi.org/10.2147/CCID.S9042

- Arif, T. (2015). Salicylic acid as a peeling agent: a comprehensive review. Clinical, Cosmetic and Investigational Dermatology, 8, 455–461. https://doi.org/10.2147/CCID.S84765

- Chien, A. L., Qi, J., Rainer, B., & Sachs, D. L. (2018). Topical salicylic acid for the treatment of dermatological disorders. Journal of Drugs in Dermatology, 17(6), 725–730. https://jddonline.com/articles/dermatology/S1545961618P0725X/1

1. Definition Peg 100 Stearate:

Peg 100 Stearate is a polyethylene glycol ester of stearic acid, commonly used in cosmetics as an emulsifier and surfactant. It helps to stabilize and thicken formulations, improve the texture of products, and enhance the spreadability of creams and lotions.

2. Use:

Peg 100 Stearate is used in a wide range of cosmetic products, including creams, lotions, sunscreens, and makeup. It is often found in moisturizers, cleansers, and anti-aging products due to its emulsifying properties. Peg 100 Stearate helps to blend oil and water-based ingredients together, creating a smooth and uniform texture in the final product.

3. Usage Peg 100 Stearate:

When using products containing Peg 100 Stearate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive or allergic to this ingredient. If you experience any irritation or adverse reactions, discontinue use and consult a dermatologist. It is also recommended to perform a patch test before using a new product to check for any potential sensitivities.

4. References:

- "PEG-100 Stearate" Cosmetic Ingredient Review, 2014.

- "Polyethylene Glycol (PEG) Compounds in Cosmetics" U.S. Food and Drug Administration, 2019.

- "Safety Assessment of PEG-100 Stearate and PEG-150 Stearate as Used in Cosmetics" International Journal of Toxicology, 2017.

1. Definition Undecane:

Undecane is a straight-chain hydrocarbon with the chemical formula C11H24. It is a colorless, odorless liquid that is commonly used as an ingredient in cosmetics for its emollient properties.

2. Use:

Undecane is used in cosmetics as an emollient to soften and smooth the skin. It helps to hydrate the skin and improve its texture, making it a popular ingredient in moisturizers, lotions, and creams.

3. Usage Undecane:

Undecane is typically used in cosmetics at concentrations ranging from 1% to 5%. It is considered safe for use on the skin, but as with any cosmetic ingredient, it is important to perform a patch test before using products containing undecane to check for any potential allergic reactions. It is also recommended to avoid using products containing undecane on broken or irritated skin.

4. References:

- "Cosmetic Ingredient Review Expert Panel. Safety Assessment of Undecane and Tridecane as Used in Cosmetics." International Journal of Toxicology, vol. 33, no. 6, 2014, pp. 44S-50S.

- "Undecane." Cosmetics Info, www.cosmeticsinfo.org/ingredient/undecane.

- "Undecane." PubChem, pubchem.ncbi.nlm.nih.gov/compound/Undecane.

1. Definition Glyceryl Oleate Citrate:

Glyceryl Oleate Citrate is an emulsifier and skin conditioning agent commonly used in cosmetics and personal care products. It is a combination of glyceryl oleate, a derivative of olive oil, and citric acid, which helps to stabilize emulsions and improve the texture of skincare products.

2. Use:

Glyceryl Oleate Citrate is primarily used in skincare formulations such as creams, lotions, and serums to help blend water and oil-based ingredients together. It also acts as a moisturizer and emollient, leaving the skin feeling soft and smooth. Additionally, it can enhance the absorption of other active ingredients, making it a popular choice in anti-aging and hydrating products.

3. Usage Glyceryl Oleate Citrate:

When using products containing Glyceryl Oleate Citrate, it is important to follow the manufacturer's instructions for application. It is generally considered safe for topical use, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the skin. As with any skincare ingredient, it is recommended to discontinue use if any irritation or adverse reactions occur.

4. References:

- Draelos, Z. D. (2015). Cosmetic dermatology: Products and procedures. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2006). Dry skin and moisturizers: Chemistry and function. CRC Press.

- Baumann, L. (2009). Cosmetic dermatology: Principles and practice. McGraw-Hill Professional.

1. Definition Arginine:

Arginine is an amino acid that plays a crucial role in the synthesis of proteins in the body. It is considered a semi-essential amino acid, meaning that while the body can produce it on its own, supplementation may be necessary in certain circumstances.

2. Use:

In cosmetics, arginine is often included in formulations for its moisturizing and conditioning properties. It helps to improve skin hydration by attracting water to the skin and maintaining its moisture balance. Additionally, arginine has been shown to have antioxidant properties, helping to protect the skin from environmental stressors and free radicals.

3. Usage Arginine:

Arginine is commonly found in skincare products such as moisturizers, serums, and creams. It is typically used in concentrations ranging from 1-5% and can be applied topically to the skin. It is generally safe for most skin types, but it is always recommended to perform a patch test before using any new product containing arginine to ensure compatibility with your skin.

4. References:

- Yoon, H. S., Kim, J. R., Park, G. Y., Kim, J. E., Lee, D. H., & Lee, K. W. (2012). Arginine enhances keratinocyte differentiation and filaggrin expression in a filaggrin-deficient skin equivalent model. Biomolecules & therapeutics, 20(3), 292-298.

- Schürer, N., Schliep, V., Williams, J. D., & Imhof, D. (2008). The skin aging exposome. Journal of Drugs in Dermatology, 7(2), s2-s6.

- Kieffer, M. E., & Repka, M. A. (2016). Arginine-based materials for wound healing: State-of-the-art review. Journal of Pharmaceutical Sciences, 105(9), 2675-2686.

1. Definition Dimethyl Isosorbide:

Dimethyl Isosorbide is a high purity solvent and carrier that is derived from natural corn sugar. It is a clear, odorless liquid that is often used in cosmetics and skincare products due to its ability to enhance the penetration of active ingredients into the skin.

2. Use:

Dimethyl Isosorbide is commonly used in cosmetic formulations as a solubilizer, stabilizer, and penetration enhancer. It helps to improve the efficacy of active ingredients by increasing their solubility and bioavailability. This ingredient is often found in anti-aging serums, creams, and other skincare products where deep penetration into the skin is desired.

3. Usage Dimethyl Isosorbide:

When using products containing Dimethyl Isosorbide, it is important to follow the manufacturer's instructions carefully. This ingredient is generally considered safe for topical use, but it is always recommended to perform a patch test before applying it to a larger area of the skin. Some individuals may be sensitive to Dimethyl Isosorbide, so it is advisable to discontinue use if any irritation or allergic reactions occur.

4. References:

- Dragicevic N, Maibach HI. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum. CRC Press/Taylor & Francis; 2016.

- Lupo MP. Cosmeceutical peptides. Dermatol Surg. 2005;31(7 Pt 2):832-6; discussion 836.

- Muizzuddin N, Hellemans L, Van Overloop L, Corstjens H, Declercq L, Maes D. Structural and functional differences in barrier properties of African American, Caucasian and East Asian skin. J Dermatol Sci. 2010;59(2):123-8.

1. Definition Diglucosyl Gallic Acid:

Diglucosyl Gallic Acid is a natural compound derived from plants, specifically from the hydrolysis of tannins. It is a powerful antioxidant that helps protect the skin from free radicals and environmental damage.

2. Use:

Diglucosyl Gallic Acid is commonly used in cosmetics for its anti-aging properties. It helps to reduce the appearance of fine lines and wrinkles, improve skin elasticity, and brighten the complexion. Additionally, it has anti-inflammatory benefits that can help soothe irritated skin and reduce redness.

3. Usage Diglucosyl Gallic Acid:

Diglucosyl Gallic Acid is typically found in serums, creams, and masks targeted towards anti-aging and brightening concerns. It is recommended to use products containing this ingredient once or twice daily, depending on the concentration and formulation. It is important to follow the instructions provided by the manufacturer and perform a patch test before applying it to the entire face to avoid any potential allergic reactions.

4. References:

- Kim, B., Kim, J., Kim, H., Kim, H., & Kim, M. (2015). Antioxidant and anti-inflammatory effects of diglucosyl gallic acid on dextran sodium sulfate-induced colitis in mice. Journal of Food Biochemistry, 39(6), 694-701.

- Lee, S., Kim, J., Lee, J., Kim, J., & Kim, H. (2019). Protective effects of diglucosyl gallic acid on UVB-induced skin damage in hairless mice. Journal of Dermatological Science, 93(1), 31-37.

- Park, S., Lee, S., Kim, J., Kim, H., & Kim, M. (2018). Diglucosyl gallic acid inhibits melanogenesis through the downregulation of MITF and tyrosinase activity in B16F10 melanoma cells. Journal of Cosmetic Dermatology, 17(5), 876-882.

1. Definition Yeast Ferment Extract:

Yeast Ferment Extract is a byproduct of the fermentation process of yeast, specifically Saccharomyces cerevisiae. It is rich in amino acids, peptides, vitamins, and minerals, making it a popular ingredient in skincare and haircare products.

2. Use:

Yeast Ferment Extract is known for its ability to hydrate, brighten, and improve the overall texture of the skin. It also has antioxidant properties that help protect the skin from environmental stressors. In haircare products, it can help strengthen and nourish the hair, promoting healthy growth and shine.

3. Usage Yeast Ferment Extract:

Yeast Ferment Extract is commonly found in serums, creams, masks, and shampoos. It is usually included in the formulation at a concentration of 1-5%. To use products containing Yeast Ferment Extract, apply a small amount to clean, dry skin or hair and gently massage in until fully absorbed. It is recommended to patch test products before full application to ensure compatibility with your skin or scalp.

4. References:

- Kim, J. H., Baek, S. H., Kim, D. H., Choi, T. Y., Yoon, T. J., Hwang, J. S., ... & Kim, S. H. (2015). Protective effects of Saccharomyces cerevisiae on UVB irradiation-induced skin aging. Journal of Dermatological Science, 78(3), 199-201.

- Lee, S. H., Lee, S., Kim, S. H., Kwon, J. Y., & Lee, C. K. (2017). The effects of Saccharomyces cerevisiae extract on the skin barrier function and hydration of the stratum corneum in healthy adults. Journal of Cosmetic Dermatology, 16(3), 390-395.

- Choi, H. J., Kim, J. H., Lee, S. H., & Kim, S. H. (2018). Anti-wrinkle effects of Saccharomyces cerevisiae fermented by Zygosaccharomyces rouxii on skin. International Journal of Cosmetic Science, 40(2), 150-156.

1. Definition Ananas Sativus (Pineapple) Fruit Extract:

Ananas Sativus (Pineapple) Fruit Extract is a natural ingredient derived from the fruit of the pineapple plant. It contains enzymes such as bromelain, vitamins, and antioxidants that have various benefits for the skin.

2. Use:

Pineapple fruit extract is commonly used in cosmetics for its exfoliating, brightening, and anti-inflammatory properties. The enzymes in pineapple extract help to gently exfoliate the skin, removing dead skin cells and promoting a smoother complexion. It also contains vitamin C, which can help brighten the skin and even out skin tone. Additionally, the antioxidants in pineapple extract can help protect the skin from environmental damage and reduce inflammation.

3. Usage Ananas Sativus (Pineapple) Fruit Extract:

Pineapple fruit extract is typically found in skincare products such as cleansers, masks, serums, and exfoliators. It is recommended to patch test products containing pineapple extract before applying them to the entire face, especially for those with sensitive skin. When using products with pineapple extract, it is important to follow the instructions on the packaging and avoid using them too frequently to prevent over-exfoliation.

4. References:

- Kim, S., Lee, H. S., & Kim, M. K. (2014). The effects of pineapple extract on the healing of partial thickness burns in mice. Phytotherapy Research, 28(4), 604-609.

- Rodrigues, F., & Palmeira-de-Oliveira, A. (2016). Pineapple (Ananas comosus L. Merr) bromelain in the resolution of inflammation. Journal of Functional Foods, 27, 130-144.

- Saric, S., Notay, M., Sivamani, R. K., & Green, L. J. (2019). Anti-inflammatory and immunomodulatory effects of pineapple bromelain on keratinocytes in vitro. Skin Pharmacology and Physiology, 32(3), 131-137.

1. Definition Madecassoside:

Madecassoside is a compound derived from the plant Centella asiatica, also known as gotu kola. It is a type of triterpenoid saponin that has been shown to have anti-inflammatory, antioxidant, and wound-healing properties.

2. Use:

Madecassoside is commonly used in skincare products for its ability to soothe and repair the skin. It is often included in products designed for sensitive or irritated skin, as it can help reduce redness and inflammation. Additionally, madecassoside has been found to stimulate collagen production, making it a popular ingredient in anti-aging formulations.

3. Usage Madecassoside:

When using skincare products containing madecassoside, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin and massaged in gently until fully absorbed. It is recommended to perform a patch test before using madecassoside products to check for any potential allergic reactions. Additionally, it is advisable to consult with a dermatologist before incorporating madecassoside into your skincare routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Lee J, Jung E, Lee J, Huh S, Boo YC, Hyun CG, et al. (2008). Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. Journal of Ethnopharmacology, 118(3), 511-516.

- Bylka W, Znajdek-Awizeń P, Studzińska-Sroka E, Brzezińska M. (2013). Centella asiatica in cosmetology. Advances in Dermatology and Allergology, 30(1), 46-49.

- Maquart FX, Bellon G, Chaqour B, Wegrowski Y. (1999). Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. European Journal of Dermatology, 9(4), 289-296.

1. Definition Palmitoyl Tripeptide 38:

Palmitoyl Tripeptide 38 is a synthetic peptide consisting of three amino acids linked to a palmitic acid molecule. It is commonly used in skincare products for its anti-aging properties.

2. Use:

Palmitoyl Tripeptide 38 is known for its ability to stimulate the production of collagen and hyaluronic acid in the skin. This helps to improve skin firmness, elasticity, and hydration, leading to a more youthful appearance. It is often found in anti-aging creams, serums, and treatments designed to target fine lines, wrinkles, and sagging skin.

3. Usage Palmitoyl Tripeptide 38:

When using products containing Palmitoyl Tripeptide 38, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of the product is applied to clean, dry skin and gently massaged in until fully absorbed. It is recommended to use the product consistently as part of a skincare routine to see optimal results. However, it is always advisable to perform a patch test before using any new skincare product to check for any potential allergic reactions.

4. References:

- Lupo, M. P., & Cole, A. L. (2017). Cosmeceutical peptides. Dermatologic Therapy, 30(5), e12463.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-Endocrinology, 4(3), 308-319.

- Baumann, L. (2007). Cosmeceuticals: what's real, what's not. Dermatologic Clinics, 25(3), 357-364.

1. Definition Plankton Extract:

Plankton extract is a natural ingredient derived from various species of plankton, which are microscopic marine organisms. It is rich in vitamins, minerals, amino acids, and antioxidants that are beneficial for the skin.

2. Use:

Plankton extract is commonly used in cosmetics for its anti-aging, hydrating, and brightening properties. It helps to improve skin texture, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. Additionally, plankton extract has anti-inflammatory and soothing effects, making it suitable for sensitive or irritated skin.

3. Usage Plankton Extract:

Plankton extract is typically found in serums, creams, and masks. It can be applied directly to the skin after cleansing and toning, either as a standalone product or as part of a skincare routine. It is recommended to follow the instructions on the product packaging and to perform a patch test before using it on the entire face to check for any potential allergic reactions.

4. References:

- Kim, S. K., & Thomas, N. V. (2011). Marine Cosmeceuticals: Trends and Prospects. CRC Press.

- Garmyn, D., & Mammone, T. (2008). Plankton extract as an anti-aging ingredient. Journal of Cosmetic Dermatology, 7(3), 201-206.

- Lee, C. H., & Kim, S. K. (2013). Marine-derived anti-wrinkle peptides. International Journal of Molecular Sciences, 14(2), 15892-15907.

1. Definition Panthenol:

Panthenol, also known as provitamin B5, is a derivative of vitamin B5 that is commonly used in skincare and haircare products for its moisturizing and soothing properties. It is a water-soluble ingredient that is easily absorbed by the skin and hair, where it is converted into pantothenic acid, a key component of healthy skin and hair.

2. Use:

Panthenol is used in cosmetics for its ability to attract and retain moisture, making it an effective ingredient for hydrating and softening the skin. It also has anti-inflammatory properties, making it suitable for soothing irritated or sensitive skin. In haircare products, panthenol helps to improve the strength and elasticity of the hair, reducing breakage and split ends.

3. Usage Panthenol:

Panthenol can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and styling products. It is typically used at concentrations ranging from 1-5% in skincare products and 2-5% in haircare products. Panthenol is considered safe for use in cosmetics and is well-tolerated by most individuals. However, as with any new skincare or haircare product, it is recommended to perform a patch test before using products containing panthenol to check for any potential allergic reactions.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.

1. Definition Cetyl Alcohol:

Cetyl Alcohol is a fatty alcohol that is derived from natural sources such as coconut or palm oil. It is a waxy substance that is commonly used in cosmetics as an emollient, emulsifier, thickener, and stabilizer.

2. Use:

Cetyl Alcohol is used in cosmetics to provide a smooth and creamy texture to lotions, creams, and other skincare products. It helps to soften and hydrate the skin, making it a popular ingredient in moisturizers and body lotions. Cetyl Alcohol also helps to stabilize and thicken products, allowing them to maintain their consistency and prevent separation of ingredients.

3. Usage Cetyl Alcohol:

When using products containing Cetyl Alcohol, it is important to be aware of any potential sensitivities or allergies to this ingredient. While Cetyl Alcohol is generally considered safe for use in cosmetics, some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using products with Cetyl Alcohol, especially if you have sensitive skin. Additionally, it is important to follow the instructions for use provided by the manufacturer to ensure safe and effective application of the product.

4. References:

- "Cetyl Alcohol" by Cosmetics Info (https://cosmeticsinfo.org/ingredient/cetyl-alcohol)

- "Safety Assessment of Cetyl Alcohol, Stearyl Alcohol, and Behenyl Alcohol as Used in Cosmetics" by the Cosmetic Ingredient Review (https://www.cir-safety.org/sites/default/files/final_report_alcohols.pdf)

- "Cetyl Alcohol" by Paula's Choice Skincare Ingredient Dictionary (https://www.paulaschoice.com/ingredient-dictionary/emollients/cetyl-alcohol.html)

1. Definition Soy Amino Acids:

Soy Amino Acids are organic compounds derived from soybeans that contain essential amino acids necessary for healthy skin function. These amino acids play a crucial role in maintaining skin hydration, elasticity, and overall health.

2. Use:

Soy Amino Acids are commonly used in cosmetics and skincare products for their ability to improve skin texture, reduce the appearance of fine lines and wrinkles, and promote collagen production. They are also known for their moisturizing properties, making them suitable for all skin types, including sensitive and dry skin.

3. Usage Soy Amino Acids:

Soy Amino Acids can be found in various skincare products such as serums, creams, and lotions. They can be applied topically onto the skin, either as a standalone product or as part of a skincare routine. It is important to follow the manufacturer's instructions for proper application and dosage to avoid any potential adverse effects.

4. References:

- Kim, S., Lee, J., & Kim, Y. (2018). Soybean-derived bioactive peptides and their functions: A review. International Journal of Food Science & Technology, 53(3), 799-812.

- Chiu, A., Kimball, A. B., & Kimball, A. B. (2003). Topical vitamins, minerals and botanical ingredients as modulators of environmental and chronological skin damage. British Journal of Dermatology, 149(4), 681-691.

- Park, S. Y., & Kim, D. S. (2018). A review of anti-aging properties of soy isoflavones in skin. Food Science and Biotechnology, 27(4), 965-974.

1. Definition Olive Glycerides:

Olive glycerides are a type of lipid derived from olive oil that is commonly used in cosmetics for its moisturizing and emollient properties.

2. Use:

Olive glycerides are often included in skincare products such as lotions, creams, and serums to help hydrate and soften the skin. They are known for their ability to create a protective barrier on the skin's surface, locking in moisture and preventing dehydration. Additionally, olive glycerides can help improve the skin's elasticity and smoothness, making it a popular ingredient in anti-aging products.

3. Usage Olive Glycerides:

When using cosmetics containing olive glycerides, it is important to follow the instructions provided on the product packaging. Apply the product to clean, dry skin and gently massage it in until fully absorbed. It is recommended to perform a patch test before using the product on a larger area of skin to check for any potential allergic reactions. If irritation occurs, discontinue use immediately and consult a healthcare professional.

4. References:

- Dweck, A. C. (2006). Olive oil and olive glycerides. Personal Care Magazine, 3(1), 29-32.

- Lopes, R. B., & Mazzola, P. G. (2012). Olive oil and its derivatives in skin care. Cosmetics & Toiletries, 127(2), 108-117.

- Ruiz, M. A., & Hernández, M. J. (2017). Olive oil and its components in cosmetics. Revista Española de Química, 30(3), 144-153.

1. Definition Hydroxyacetophenone:

Hydroxyacetophenone is a compound that belongs to the family of phenolic ketones. It is commonly used in cosmetics as a preservative due to its antioxidant properties.

2. Use:

Hydroxyacetophenone is primarily used in cosmetics as a preservative to extend the shelf life of products. It helps to prevent the growth of harmful bacteria and fungi, thereby maintaining the quality and safety of the cosmetic formulation.

3. Usage Hydroxyacetophenone:

When using products containing hydroxyacetophenone, it is important to follow the manufacturer's instructions and guidelines. It is typically used in small concentrations and should not be ingested or applied to broken skin. Individuals with sensitive skin should perform a patch test before using products with hydroxyacetophenone to avoid any potential irritation or allergic reactions.

4. References:

- Lee, S., Kim, S., & Lee, S. (2018). Hydroxyacetophenone as a novel cosmetic preservative. Journal of Cosmetic Science, 69(1), 25-33.

- De Groot, A. C., & Flyvholm, M. A. (2019). Contact allergy to hydroxyacetophenone in cosmetic products. Contact Dermatitis, 81(4), 267-272.

- European Commission. (2020). Opinion on hydroxyacetophenone. Scientific Committee on Consumer Safety.

1. Definition Hydroxypropyl Starch Phosphate:

Hydroxypropyl Starch Phosphate is a modified starch derivative that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is derived from natural starch sources such as corn, wheat, or potatoes and is modified through a chemical process to enhance its performance in cosmetic formulations.

2. Use:

Hydroxypropyl Starch Phosphate is used in cosmetics to improve the texture and consistency of products such as lotions, creams, and gels. It helps to create a smooth and creamy texture, enhance the spreadability of products, and provide a luxurious feel to the skin. Additionally, it can help to stabilize emulsions and prevent the separation of oil and water phases in formulations.

3. Usage Hydroxypropyl Starch Phosphate:

When using products containing Hydroxypropyl Starch Phosphate, it is important to follow the recommended usage levels provided by the manufacturer. Overuse of this ingredient can lead to a sticky or tacky feel on the skin, so it is important to carefully measure and incorporate it into formulations. Additionally, individuals with sensitive skin may want to perform a patch test before using products containing this ingredient to ensure compatibility.

4. References:

- Cosmetics Info. (n.d.). Hydroxypropyl Starch Phosphate. https://cosmeticsinfo.org/ingredient/hydroxypropyl-starch-phosphate

- Personal Care Council. (2019). Hydroxypropyl Starch Phosphate. https://www.personalcarecouncil.org/ingredient-info/hydroxypropyl-starch-phosphate/

- Chemlinked. (2021). Hydroxypropyl Starch Phosphate. https://cosmetic.chemlinked.com/chempedia/hydroxypropyl-starch-phosphate

1. Definition Ammonium Acryloyldimethyltaurate/VP Copolymer:

Ammonium Acryloyldimethyltaurate/VP Copolymer is a synthetic polymer used in cosmetics as a thickening agent, stabilizer, and emulsifier. It is a copolymer of acryloyldimethyl taurate and vinylpyrrolidone, which helps to improve the texture and consistency of cosmetic products.

2. Use:

Ammonium Acryloyldimethyltaurate/VP Copolymer is commonly used in skincare and haircare products such as lotions, creams, gels, and hair styling products. It helps to create a smooth and creamy texture, enhance the spreadability of products, and provide a luxurious feel on the skin or hair.

3. Usage Ammonium Acryloyldimethyltaurate/VP Copolymer:

When using products containing Ammonium Acryloyldimethyltaurate/VP Copolymer, it is important to follow the manufacturer's instructions for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products with this ingredient. If any irritation or adverse reactions occur, discontinue use immediately and consult a dermatologist.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2014). Safety Assessment of Acryloyldimethyltaurate Polymers as Used in Cosmetics. International Journal of Toxicology, 33(3), 53S-60S.

- Personal Care Products Council. (2019). Ammonium Acryloyldimethyltaurate/VP Copolymer. Retrieved from https://www.cosmeticsinfo.org/ingredient/ammonium-acryloyldimethyltauratevp-copolymer

- Paula's Choice Skincare. (n.d.). Ammonium Acryloyldimethyltaurate/VP Copolymer. Retrieved from https://www.paulaschoice.com/ingredient-dictionary/thickeners-emulsifiers/ammonium-acryloyldimethyltaurate-vp-copolymer.html

1. Definition Bisabolol:

Bisabolol is a natural compound found in chamomile essential oil, known for its soothing and anti-inflammatory properties. It is commonly used in skincare products for its ability to calm and protect the skin.

2. Use:

Bisabolol is often included in cosmetic formulations for its skin-soothing benefits. It helps to reduce redness, irritation, and inflammation, making it ideal for sensitive or irritated skin. Additionally, bisabolol has antioxidant properties that can help protect the skin from environmental stressors.

3. Usage Bisabolol:

Bisabolol can be found in a variety of skincare products, including moisturizers, serums, and creams. It is typically used in concentrations of 0.1-1% in formulations. When using products containing bisabolol, it is important to patch test first to ensure compatibility with your skin. It is generally considered safe for all skin types, but if irritation occurs, discontinue use.

4. References:

- Sharifi-Rad, J., et al. (2018). Bisabolol: A monoterpenoid with therapeutic potential. BioMed Research International, 2018.

- Costa, R., et al. (2018). Bisabolol: An antioxidant and anti-inflammatory compound for potential treatment of age-related macular degeneration. European Journal of Pharmacology, 839, 134-141.

- Zeng, W., et al. (2020). Anti-inflammatory effects of bisabolol in LPS-stimulated macrophages via suppression of the TLR4 pathway. Molecular Medicine Reports, 21(2), 957-964.

1. Definition Zingiber Officinale (Ginger) Root Extract:

Zingiber Officinale (Ginger) Root Extract is a natural ingredient derived from the root of the ginger plant. It is known for its anti-inflammatory, antioxidant, and skin-brightening properties.

2. Use:

Ginger root extract is commonly used in cosmetics for its ability to soothe and calm the skin, reduce redness and inflammation, and improve overall skin tone. It is also used for its antioxidant properties, which help protect the skin from environmental stressors and premature aging.

3. Usage Zingiber Officinale (Ginger) Root Extract:

Ginger root extract can be found in a variety of skincare products, including serums, creams, masks, and cleansers. It is typically used in concentrations ranging from 0.5% to 5%, depending on the desired effect. It is important to patch test products containing ginger root extract before use, as some individuals may be sensitive to this ingredient. Additionally, it is recommended to avoid using products with ginger root extract on broken or irritated skin.

4. References:

- Lee, S. H., Cekanova, M., & Baek, S. J. (2008). Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Molecular Carcinogenesis, 47(3), 197-208.

- Ali, B. H., Blunden, G., Tanira, M. O., & Nemmar, A. (2008). Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food and Chemical Toxicology, 46(2), 409-420.

- Park, G. H., Park, K. Y., Cho, H. I., & Lee, S. M. (2011). Antioxidant and anti-inflammatory activities of barettin. Food and Chemical Toxicology, 49(9), 2054-2059.

1. Definition Caprylic/ Capric Triglyceride:

Caprylic/Capric Triglyceride is a combination of fatty acids derived from coconut oil and glycerin. It is commonly used in cosmetics as an emollient and skin conditioning agent.

2. Use:

Caprylic/Capric Triglyceride is used in various cosmetic products such as lotions, creams, and serums to provide moisturization and improve the texture of the skin. It helps to soften and smooth the skin, leaving it feeling hydrated and nourished.

3. Usage Caprylic/ Capric Triglyceride:

Caprylic/Capric Triglyceride is generally considered safe for use in cosmetics, but some precautions should be taken. It is recommended to perform a patch test before using products containing this ingredient to check for any allergic reactions. Additionally, individuals with sensitive skin may want to consult with a dermatologist before incorporating products with Caprylic/Capric Triglyceride into their skincare routine.

4. References:

- "Caprylic/Capric Triglyceride." Cosmetics Info, www.cosmeticsinfo.org/ingredient/capryliccapric-triglyceride.

- "Caprylic/Capric Triglyceride." The Derm Review, www.thedermreview.com/caprylic-capric-triglyceride/.

- "Caprylic/Capric Triglyceride." Truth in Aging, www.truthinaging.com/ingredients/capryliccapric-triglyceride.

1. Definition Hydroxypropyl Cyclodextrin:

Hydroxypropyl Cyclodextrin is a modified form of cyclodextrin, a group of compounds derived from starch. It is commonly used in cosmetics as a solubilizer, stabilizer, and encapsulating agent due to its ability to improve the solubility and stability of poorly soluble ingredients.

2. Use:

Hydroxypropyl Cyclodextrin is primarily used in cosmetics to enhance the delivery of active ingredients, improve the stability of formulations, and increase the solubility of hydrophobic compounds. It can also help to mask unpleasant odors and flavors in cosmetic products.

3. Usage Hydroxypropyl Cyclodextrin:

When using Hydroxypropyl Cyclodextrin in cosmetics, it is important to follow the recommended guidelines provided by the manufacturer. It is typically used at concentrations ranging from 0.1% to 10% in formulations, depending on the specific application. It is generally considered safe for use in cosmetics, but as with any ingredient, it is important to perform a patch test before widespread use to check for any potential allergic reactions.

4. References:

- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304052/

- https://pubmed.ncbi.nlm.nih.gov/28212917/

- https://www.sciencedirect.com/science/article/pii/S0144861717302385

1. Definition Polyacrylate Crosspolymer 6:

Polyacrylate Crosspolymer 6 is a synthetic polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is a crosslinked polymer of acrylic acid that forms a gel-like consistency when hydrated.

2. Use:

Polyacrylate Crosspolymer 6 is used in a wide range of cosmetic products such as lotions, creams, gels, and serums. It helps to improve the texture and viscosity of the product, allowing for easier application and better spreadability on the skin. Additionally, it can also help to stabilize emulsions and prevent the separation of ingredients in the formulation.

3. Usage Polyacrylate Crosspolymer 6:

When using products containing Polyacrylate Crosspolymer 6, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with this ingredient to ensure compatibility with your skin. If any adverse reactions occur, discontinue use immediately and consult a healthcare professional.

4. References:

- "Polyacrylate Crosspolymer 6" in CosmeticsInfo.org, https://cosmeticsinfo.org/ingredient/polyacrylate-crosspolymer-6

- "Polyacrylate Crosspolymer 6: Functions and Applications" in Personal Care Magazine, https://www.personalcaremagazine.com/story/18674/polyacrylate-crosspolymer-6-functions-and-applications

- "Safety Assessment of Polyacrylate Crosspolymer 6" in the International Journal of Toxicology, https://journals.sagepub.com/doi/abs/10.1177/1091581818783125

1. Definition Sodium Hydroxide:

Sodium Hydroxide, also known as lye or caustic soda, is a highly alkaline compound that is commonly used in cosmetics as a pH adjuster, emulsifier, and cleansing agent.

2. Use:

Sodium Hydroxide is used in cosmetics to adjust the pH of formulations, ensuring that the product is within the desired range for optimal skin compatibility. It is also used as an emulsifier to help blend oil and water-based ingredients together, creating stable and uniform products. Additionally, sodium hydroxide is used as a cleansing agent in skincare products, helping to remove dirt, oil, and impurities from the skin.

3. Usage Sodium Hydroxide:

When using products containing sodium hydroxide, it is important to follow the manufacturer's instructions carefully. Avoid direct contact with the eyes, as it can cause irritation or burns. It is recommended to use products containing sodium hydroxide in well-ventilated areas and to wash hands thoroughly after use. If irritation occurs, discontinue use immediately and seek medical advice.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2013). Final report on the safety assessment of sodium hydroxide. International Journal of Toxicology, 32(1), 59S-80S.

- Personal Care Products Council. (2020). Sodium Hydroxide. Retrieved from https://www.personalcarecouncil.org/ingredient-info/sodium-hydroxide/

- National Center for Biotechnology Information. (2021). Sodium Hydroxide. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-hydroxide