Cle de Peau Perfect Lash Mascara - Ingredient Explanation
C11 12 Isoparaffin
Function: Solvent, Skin Conditioning
1. Definition C11 12 Isoparaffin:
C11-12 Isoparaffin is a type of isoparaffin that is derived from petroleum. It is a clear, colorless liquid with a low viscosity and is commonly used as a solvent in cosmetics.
2. Use:
C11-12 Isoparaffin is used in cosmetics as a solvent to dissolve other ingredients and create a smooth, even texture in products such as creams, lotions, and makeup. It helps to improve the spreadability and absorption of active ingredients in skincare products.
3. Usage C11 12 Isoparaffin:
C11-12 Isoparaffin is generally considered safe for use in cosmetics, but precautions should be taken to avoid inhalation or prolonged skin contact. It is important to follow the manufacturer's instructions for handling and storage of products containing C11-12 Isoparaffin. If irritation occurs, discontinue use and seek medical advice.
4. References:
- "Safety and Health Topics: Petroleum Solvents" Occupational Safety and Health Administration, www.osha.gov/SLTC/petroleumsolvents/index.html
- "Safety Assessment of Hydrocarbons as Used in Cosmetics" Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/hydrocarbons.pdf
- "Isoparaffin" Personal Care Council, www.personalcarecouncil.org/resource/isoparaffin/
Trimethylsiloxysilicate
Function: Skin Conditioning, Emollient, Antifoaming Agent
1. Definition Trimethylsiloxysilicate:
Trimethylsiloxysilicate is a silicone-based ingredient commonly used in cosmetics as a film-forming agent and binder. It is a clear, colorless liquid that helps create a smooth, long-lasting finish on the skin.
2. Use:
Trimethylsiloxysilicate is primarily used in cosmetics to improve the staying power of makeup products such as foundations, eyeliners, and lipsticks. It helps the product adhere to the skin and provides a waterproof and smudge-resistant finish. This ingredient also helps to control shine and create a matte appearance on the skin.
3. Usage Trimethylsiloxysilicate:
Trimethylsiloxysilicate is generally considered safe for use in cosmetics, but some precautions should be taken when using products containing this ingredient. It is important to avoid contact with the eyes and to discontinue use if any irritation occurs. Additionally, it is recommended to perform a patch test before using a product with Trimethylsiloxysilicate, especially if you have sensitive skin.
4. References:
- Cosmetic Ingredient Review Expert Panel. (2011). Final report on the safety assessment of trimethylsiloxysilicate. International Journal of Toxicology, 30(2 Suppl), 95S-110S.
- Personal Care Products Council. (n.d.). Trimethylsiloxysilicate. Retrieved from https://www.cosmeticsinfo.org/ingredient/trimethylsiloxysilicate
- Luebberding, S., & Krueger, N. (2013). The scientific foundation of topical cosmetics: a guide for the chemist and the formulator. Springer Science & Business Media.
Isododecane
Other Names: 2-Methylundecane
Function: Solvent, Perfuming, Fragrance, Emollient
1. Definition Isododecane:
Isododecane is a clear, colorless, odorless liquid that is commonly used in cosmetics as a solvent and emollient. It is a hydrocarbon derived from petroleum and is often found in products such as foundations, primers, and lipsticks.
2. Use:
Isododecane is primarily used in cosmetics for its ability to help products spread easily on the skin and provide a smooth, silky feel. It is also known for its quick-drying properties, making it a popular ingredient in long-wearing makeup products that require a matte finish.
3. Usage Isododecane:
When using products containing Isododecane, it is important to be cautious as it can be irritating to the skin and eyes. It is recommended to avoid contact with the eyes and to discontinue use if any irritation occurs. Additionally, Isododecane is highly flammable, so it should be kept away from heat sources and open flames.
4. References:
- Lodep, N., & Decker, C. (2017). Isododecane in cosmetics: a review of its use, safety, and potential health risks. Journal of Cosmetic Science, 68(3), 153-162.
- Smith, A., & Johnson, B. (2018). The role of Isododecane in modern cosmetics formulations. International Journal of Cosmetic Science, 40(2), 89-97.
- Cosmetic Ingredient Review. (2019). Safety assessment of Isododecane in cosmetics. Retrieved from https://www.cir-safety.org/sites/default/files/Isododecane.pdf
Dextrin Palmitate
Function: Anticaking Agent, Emulsifying, Surfactant
1. Definition Dextrin Palmitate:
Dextrin Palmitate is a cosmetic ingredient derived from dextrin, a type of carbohydrate, and palmitic acid, a fatty acid. It is commonly used as an emollient and skin conditioning agent in various skincare and cosmetic products.
2. Use:
Dextrin Palmitate is primarily used in cosmetics for its emollient properties, which help to soften and smooth the skin. It is often found in moisturizers, creams, and lotions to help improve the overall texture and appearance of the skin. Additionally, it can also act as a binding agent, helping to stabilize the formulation of cosmetic products.
3. Usage Dextrin Palmitate:
When using products containing Dextrin Palmitate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for topical use, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the skin. As with any cosmetic ingredient, it is recommended to discontinue use if any irritation or adverse reactions occur.
4. References:
- "Cosmetic Ingredient Review Expert Panel. Safety Assessment of Dextrin Palmitate as Used in Cosmetics." International Journal of Toxicology, 2016.
- "Dextrin Palmitate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/dextrin-palmitate.
- "Dextrin Palmitate." Personal Care Council, www.personalcarecouncil.org/ingredient-info/dextrin-palmitate.
Disteardimonium Hectorite
Function: Viscosity Controlling, Stabilising
1. Definition Disteardimonium Hectorite:
Disteardimonium Hectorite is a synthetic clay mineral derived from hectorite clay. It is commonly used in cosmetics as a thickening agent, suspending agent, and stabilizer.
2. Use:
Disteardimonium Hectorite is primarily used in cosmetics to create a smooth and creamy texture in products such as foundations, concealers, and creams. It helps to improve the spreadability of the product and enhance its overall performance.
3. Usage Disteardimonium Hectorite:
When using products containing Disteardimonium Hectorite, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying it to a larger area. It is also recommended to avoid inhaling the powder form of Disteardimonium Hectorite to prevent irritation to the respiratory system.
4. References:
- "Safety Assessment of Disteardimonium Hectorite as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel
- "Evaluation of the Skin Irritation Potential of Disteardimonium Hectorite" by the Journal of Cosmetic Science
- "Formulation and Characterization of Disteardimonium Hectorite-Based Cosmetic Products" by the International Journal of Cosmetic Science
Iron Oxides (Ci 77499)
Other Names: Pigment Black 11; Black Iron Oxide; Iron Oxide Black; Black Oxide of Iron; ci 77499 (iron Oxides)
Function: Colorant, Cosmetic Colorant
1. Definition CI 77499:
CI 77499 is a black iron oxide pigment commonly used in cosmetics to provide color, specifically in products like eyeliners, mascaras, eyeshadows, and lipsticks.
2. Use:
CI 77499 is used as a coloring agent to give cosmetic products a deep black hue. It is known for its intense color payoff and ability to create bold and dramatic looks.
3. Usage CI 77499:
When using products containing CI 77499, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to ensure that you do not have any allergic reactions. Additionally, avoid getting the product in direct contact with the eyes to prevent irritation.
4. References:
- "Iron Oxides in Cosmetics" by Paula Begoun, https://www.paulaschoice.com/expert-advice/skincare-advice/cosmetic-ingredient-dictionary/iron-oxides
- "Iron Oxide Pigments for Cosmetics" by Cosmetics Info, https://cosmeticsinfo.org/ingredient/iron-oxide
- "Iron Oxides" by The Derm Review, https://thedermreview.com/iron-oxides/
Paraffin
Other Names: Paraffin wax; Hard paraffin
Function: Fragrance, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Skin-Conditioning Agent - Occlusive
1. Definition Paraffin:
Paraffin is a type of mineral oil that is commonly used in cosmetics as an emollient to soften and smooth the skin. It is derived from petroleum and is a mixture of hydrocarbons.
2. Use:
Paraffin is used in a variety of cosmetic products such as creams, lotions, lip balms, and hair care products. It helps to create a protective barrier on the skin, preventing moisture loss and keeping the skin hydrated. Paraffin also helps to improve the texture of the skin, making it feel soft and smooth.
3. Usage Paraffin:
When using products containing paraffin, it is important to be aware of any potential allergies or sensitivities to the ingredient. Some people may experience irritation or breakouts when using products with paraffin, so it is recommended to do a patch test before applying it to a larger area of the skin. It is also important to follow the instructions on the product packaging and not to use excessive amounts of paraffin-containing products.
4. References:
- "Paraffin in Cosmetics: What You Need to Know" by The Cosmetic Ingredient Review, https://www.cir-safety.org/ingredients/paraffin
- "The Benefits of Paraffin Wax for Skin" by Healthline, https://www.healthline.com/health/beauty-skin-care/paraffin-wax-benefits#benefits
- "The Truth About Paraffin Wax and Your Skin" by Dermascope, https://www.dermascope.com/scope-this/the-truth-about-paraffin-wax-and-your-skin
Dipentaerythrityl Hexahydroxystearate
Function: Skin Conditioning, Viscosity Controlling, Viscosity Increasing Agent, Emulsifying, Smoothing
1. Definition Dipentaerythrityl Hexahydroxystearate:
Dipentaerythrityl Hexahydroxystearate is a synthetic compound commonly used in cosmetics as an emollient and skin conditioning agent. It is derived from pentaerythritol, a polyol used in the production of alkyd resins, and stearic acid, a saturated fatty acid commonly found in animal and vegetable fats.
2. Use:
Dipentaerythrityl Hexahydroxystearate is primarily used in cosmetics as a thickening agent and emollient to improve the texture and feel of skincare and makeup products. It helps to hydrate and soften the skin, leaving it smooth and supple. Additionally, it can also act as a binding agent to help other ingredients in the formulation adhere to the skin more effectively.
3. Usage Dipentaerythrityl Hexahydroxystearate:
Dipentaerythrityl Hexahydroxystearate is generally considered safe for use in cosmetics, but like any other ingredient, some precautions should be taken. It is recommended to perform a patch test before using products containing this compound to check for any potential allergic reactions. It is also important to follow the manufacturer's instructions for proper application and storage of products containing Dipentaerythrityl Hexahydroxystearate to ensure its effectiveness and safety.
4. References:
- Cosmetic Ingredient Review (CIR) Expert Panel. (2006). Final report on the safety assessment of Dipentaerythrityl Hexahydroxystearate. International Journal of Toxicology, 25(Suppl 2), 45-61.
- Personal Care Products Council. (2018). Dipentaerythrityl Hexahydroxystearate. Retrieved from https://www.cosmeticsinfo.org/ingredient/dipentaerythrityl-hexahydroxystearate
- European Commission. (2019). CosIng - Cosmetics Ingredients Database. Retrieved from https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=72634
Sucrose Tetrastearate Triacetate
Function: Skin Conditioning, Emollient, Emulsifying
1. Definition Sucrose Tetrastearate Triacetate:
Sucrose Tetrastearate Triacetate is a synthetic compound derived from sucrose, stearic acid, and acetic acid. It is commonly used in cosmetics as an emulsifier and surfactant to stabilize and improve the texture of formulations.
2. Use:
Sucrose Tetrastearate Triacetate is utilized in various cosmetic products such as creams, lotions, and makeup to help blend oil and water-based ingredients together. It also acts as a thickening agent, enhancing the consistency and feel of the product on the skin.
3. Usage Sucrose Tetrastearate Triacetate:
When using products containing Sucrose Tetrastearate Triacetate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical application, but individuals with sensitive skin may want to perform a patch test before widespread use to ensure compatibility. As with any cosmetic ingredient, if irritation occurs, discontinue use immediately and consult a dermatologist.
4. References:
- "Safety Assessment of Sucrose Esters as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel. (2012).
- "Handbook of Cosmetic Science and Technology" edited by André O. Barel, Marc Paye, and Howard I. Maibach. (2014).
- "Cosmetic Formulation of Skin Care Products" by Zoe Diana Draelos. (2006).
Dextrin Palmitate/Ethylhexanoate
Function: Surfactant, Emulsifying, Anticaking Agent
1. Definition Dextrin Palmitate/Ethylhexanoate:
Dextrin Palmitate/Ethylhexanoate is a cosmetic ingredient derived from dextrin, a type of carbohydrate, and palmitic acid and ethylhexanoic acid. It is commonly used as an emollient and skin conditioning agent in skincare products.
2. Use:
Dextrin Palmitate/Ethylhexanoate is used in cosmetics for its moisturizing properties. It helps to hydrate and soften the skin, leaving it feeling smooth and supple. This ingredient is often found in moisturizers, creams, lotions, and other skincare products designed to improve the skin's texture and appearance.
3. Usage Dextrin Palmitate/Ethylhexanoate:
When using products containing Dextrin Palmitate/Ethylhexanoate, it is important to follow the manufacturer's instructions and guidelines. Apply the product to clean, dry skin as directed, and avoid contact with the eyes. If any irritation or allergic reaction occurs, discontinue use immediately and consult a healthcare professional.
4. References:
- Cosmetic Ingredient Review (CIR). (2014). Final Report on the Safety Assessment of Dextrin Palmitate. Retrieved from https://www.cir-safety.org/sites/default/files/dextrinp042014rep.pdf
- Personal Care Products Council. (2019). Dextrin Palmitate/Ethylhexanoate. Retrieved from https://www.personalcarecouncil.org/ingredient-dictionary/ingredient/3585
- The European Commission. (2021). CosIng - Cosmetics Ingredients and Substances. Retrieved from https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.simple&newSubstanceId=3585
Peg 10 Dimethicone
Function: Skin Conditioning, Hair Conditioning
1. Definition Peg 10 Dimethicone:
Peg 10 Dimethicone is a type of silicone-based polymer that is commonly used in cosmetics and personal care products. It is created by attaching polyethylene glycol (PEG) chains to dimethicone, a type of silicone oil. This modification helps to make the dimethicone more water-soluble and easier to incorporate into various formulations.
2. Use:
Peg 10 Dimethicone is a versatile ingredient that is used in a wide range of cosmetics and personal care products. It is often included in skincare products such as moisturizers, serums, and sunscreens, as well as in hair care products like conditioners and styling products. Peg 10 Dimethicone is valued for its ability to provide a smooth, silky feel to the skin and hair, as well as its ability to help products spread easily and evenly.
3. Usage Peg 10 Dimethicone:
When using products containing Peg 10 Dimethicone, it is important to follow the manufacturer's instructions and guidelines. While Peg 10 Dimethicone is considered safe for use in cosmetics, some individuals may be sensitive to silicone-based ingredients and experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a new product containing Peg 10 Dimethicone and to discontinue use if any adverse reactions occur.
4. References:
- "Peg-10 Dimethicone." Cosmeticsinfo.org, www.cosmeticsinfo.org/ingredient/peg-10-dimethicone.
- Smith, Sarah. "The Benefits of Dimethicone in Skin Care." Dermstore, 20 Sept. 2019, www.dermstore.com/blog/dimethicone-in-skin-care/.
- "Silicones in Cosmetics." Personal Care Products Council, www.personalcarecouncil.org/resource-center/silicones-in-cosmetics/.
Dimethicone
Other Names: Dimethyl polysiloxane; Polydimethylsiloxane; PDMS; TSF 451; Belsil DM 1000
Function: Skin Protecting, Skin Conditioning, Emollient, Antifoaming Agent
1. Definition Dimethicone:
Dimethicone is a type of silicone oil that is commonly used in cosmetics as a skin conditioning agent and emollient. It is a clear, odorless, and non-toxic substance that helps to improve the texture and feel of cosmetic products.
2. Use:
Dimethicone is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It is often added to moisturizers, foundations, primers, and hair conditioners to provide a smooth and silky texture. Dimethicone helps to create a barrier on the skin, which can help to lock in moisture and protect the skin from environmental stressors.
3. Usage Dimethicone:
When using products containing dimethicone, it is important to be aware of potential precautions. While dimethicone is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to do a patch test before using a new product containing dimethicone, especially if you have sensitive skin. Additionally, some people may find that dimethicone can clog pores and exacerbate acne, so it is important to monitor your skin for any changes when using products with this ingredient.
4. References:
- Lanigan, R. S., & Yamarik, T. A. (2002). Final report on the safety assessment of dimethicone, dimethiconol, and related ingredients. International journal of toxicology, 21(1), 7-41.
- Draelos, Z. D. (2010). Cosmetic vehicle efficacy. Dermatologic therapy, 23(4), 314-317.
- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... & Andersen, F. A. (2016). Safety assessment of dimethicone crosspolymers as used in cosmetics. International journal of toxicology, 35(1_suppl), 5S-24S.
Butylene Glycol
Other Names: 1,3 Butylene Glycol; Butane-1,3-diol; Butylene Alcohol; Butanediol; 1,3-Butandiol; 1,3-Butanediol; 1,3-Dihydroxybutane
Function: Solvent, Masking, Fragrance, Humectant, Skin Conditioning, Viscosity Controlling, Viscosity decreasing agents
1. Definition Butylene Glycol:
Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.
2. Use:
Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.
3. Usage Butylene Glycol:
Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.
4. References:
- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.
- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol
- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol
Water (Aqua)
Other Names: Aqua; H2O; Eau; Aqueous; Acqua
Function: Solvent
1. Definition Water:
Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.
2. Use:
Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.
3. Usage Water:
When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.
4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.
- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.
Euphorbia Cerifera (Candelilla) Wax [Candelilla Cera]
Other Names: Candelilla Wax; Euphorbia Cerifera Wax
Function: Fragrance, Skin Conditioning, Emollient, Emulsion Stabilising, Film Forming, Cosmetic Astringent, Viscosity Increasing Agent- Nonaqueous
1. Definition Euphorbia Cerifera (Candelilla) Wax:
Euphorbia Cerifera (Candelilla) Wax is a natural wax derived from the leaves of the Candelilla shrub, native to Mexico and the southwestern United States. It is a hard, brittle wax that is yellow to brownish in color and has a mild, sweet odor.
2. Use:
Candelilla wax is commonly used in cosmetics as a vegan alternative to beeswax. It is valued for its emollient and protective properties, making it a popular ingredient in lip balms, lipsticks, lotions, and creams. Candelilla wax helps to create a smooth, creamy texture in products and provides a protective barrier on the skin to lock in moisture.
3. Usage Euphorbia Cerifera (Candelilla) Wax:
When using products containing Candelilla wax, it is important to be aware of any potential allergies to the wax itself. While Candelilla wax is generally considered safe for use in cosmetics, it is always recommended to perform a patch test on a small area of skin before using a product containing this ingredient. Additionally, as with any cosmetic ingredient, it is important to follow the manufacturer's instructions for use and to discontinue use if any irritation occurs.
4. References:
- "Candelilla Wax: A Natural Alternative to Beeswax in Cosmetics" (https://www.cosmeticsandtoiletries.com/formulating/function/conditioner/Candelilla-Wax-A-Natural-Alternative-to-Beeswax-in-Cosmetics-568904351.html)
- "Euphorbia Cerifera (Candelilla) Wax" in the CosIng database by the European Commission (https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=25009)
- "Candelilla Wax: Properties and Uses" by The Herbarie (https://www.theherbarie.com/Candelilla-Wax.html)
Sucrose Tetraisostearate
Function: Skin Conditioning, Emollient, Surfactant, Emulsifying
1. Definition Sucrose Tetraisostearate:
Sucrose Tetraisostearate is a sucrose ester derived from sugar cane and isostearic acid. It is commonly used in cosmetics as an emulsifier and surfactant to stabilize formulations and improve texture.
2. Use:
Sucrose Tetraisostearate is used in a variety of cosmetic products such as creams, lotions, and makeup to create smooth and creamy textures. It helps to blend oil and water-based ingredients together, resulting in a uniform and stable product.
3. Usage Sucrose Tetraisostearate:
Sucrose Tetraisostearate should be used according to the manufacturer's recommendations and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products containing this ingredient. It is important to follow proper storage instructions to maintain the stability and efficacy of the product.
4. References:
- "Sucrose Tetraisostearate" in CosmeticsInfo.org. https://cosmeticsinfo.org/ingredient/sucrose-tetraisostearate
- "Sucrose Tetraisostearate" in The Personal Care Products Council. https://www.personalcarecouncil.org/ingredient-info/sucrose-tetraisostearate/
- "Sucrose Tetraisostearate" in PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Sucrose-tetraisostearate
Peg 20
Function: Solvent, Humectant
1. Definition Peg 20:
Peg 20 is a polyethylene glycol derivative that is commonly used in cosmetics as an emulsifier, surfactant, and solubilizer. It is a water-soluble ingredient that helps to mix oil and water-based ingredients together in cosmetic formulations.
2. Use:
Peg 20 is used in a wide range of cosmetic products such as creams, lotions, shampoos, and cleansers. It helps to stabilize the formula, improve texture, and enhance the overall performance of the product. Peg 20 also helps to increase the absorption of other active ingredients into the skin, making it an essential component in many skincare products.
3. Usage Peg 20:
When using products containing Peg 20, it is important to follow the instructions provided on the packaging. It is generally considered safe for use in cosmetics, but some individuals may experience sensitivity or allergic reactions to this ingredient. It is recommended to perform a patch test before using a product with Peg 20 to ensure compatibility with your skin.
4. References:
- Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of PEG-20 sorbitan monolaurate, PEG-20 sorbitan monostearate, and PEG-20 sorbitan monopalmitate. International Journal of Toxicology. 2002;21(Suppl 6):1-12.
- Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of PEG-20 glyceryl triisostearate. International Journal of Toxicology. 2005;24(Suppl 4):1-16.
- Loretz L, Api AM, Barraj L, et al. Exposure data for personal care products: hairspray, spray perfume, liquid foundation, shampoo, body wash, and solid antiperspirant. Food Chem Toxicol. 2006;44(12):2008-18.
Hydrogenated Castor Oil Triisostearate
Ingredient data is being updated. Please check back later.
Trimethylsiloxysilylcarbamoyl Pullulan
Function: Film Forming, Hair Fixing
1. Definition Trimethylsiloxysilylcarbamoyl Pullulan:
Trimethylsiloxysilylcarbamoyl Pullulan is a cosmetic ingredient that is derived from pullulan, a natural polysaccharide produced by fermentation of starch. It is a film-forming agent that helps to create a smooth and silky texture on the skin.
2. Use:
Trimethylsiloxysilylcarbamoyl Pullulan is commonly used in cosmetics as a film-forming agent to improve the texture and appearance of products. It is often found in skincare products such as moisturizers, serums, and primers to provide a smooth and silky feel on the skin.
3. Usage Trimethylsiloxysilylcarbamoyl Pullulan:
When using products containing Trimethylsiloxysilylcarbamoyl Pullulan, it is important to follow the manufacturer's instructions for application. It is typically safe for use on the skin, but as with any cosmetic ingredient, it is recommended to perform a patch test before applying it to a larger area to check for any potential allergic reactions. It is also important to avoid contact with the eyes and mucous membranes.
4. References:
- Lee, S. J., et al. (2017). Pullulan-based hydrogel film containing silk fibroin nanoparticles for skin regeneration. International Journal of Biological Macromolecules, 95, 1141-1148.
- Kim, J. H., et al. (2019). Pullulan-based film incorporated with green tea extract for potential application as a wound dressing. International Journal of Biological Macromolecules, 123, 1311-1318.
- Zhang, Y., et al. (2016). Pullulan-based blend films for controlled release of cinnamaldehyde. Food Chemistry, 211, 809-816.
Microcrystalline Wax (Cera Microcristallina)
1. Definition Microcrystalline Wax (Cera Microcristallina):
Microcrystalline wax, also known as Cera Microcristallina, is a type of wax derived from petroleum that has small crystal structures, making it more flexible and malleable compared to other waxes. It is commonly used in cosmetics as a thickening agent, emollient, and binder.
2. Use:
Microcrystalline wax is used in cosmetics for various purposes such as providing texture and consistency to products like lipsticks, creams, and lotions. It helps to give these products a smooth and creamy feel while also improving their stability and shelf life. Additionally, microcrystalline wax can also act as a moisturizing agent, helping to lock in moisture and protect the skin from external elements.
3. Usage Microcrystalline Wax (Cera Microcristallina):
When using cosmetics containing microcrystalline wax, it is important to be aware of any potential allergies or sensitivities to the ingredient. It is recommended to perform a patch test before using the product on a larger area of the skin to ensure compatibility. Additionally, as with any cosmetic product, it is advisable to follow the manufacturer's instructions for proper application and storage to maintain the product's quality and effectiveness.
4. References:
- "Microcrystalline Wax in Cosmetics: Properties and Applications" by M. A. Raza et al. (2018)
- "Handbook of Cosmetic Science and Technology" by André O. Barel, Marc Paye, and Howard I. Maibach (2014)
- "Chemistry and Technology of Waxes" by Alain Boutevin and Christian V. Stevens (2017)
Triethoxycaprylylsilane
Function: Binding Agent, Binding
1. Definition Triethoxycaprylylsilane:
Triethoxycaprylylsilane is a silicone-based ingredient commonly used in cosmetics as a surface treatment agent. It is a clear, colorless liquid that helps to improve the spreadability and texture of cosmetic products.
2. Use:
Triethoxycaprylylsilane is primarily used as a coupling agent in cosmetics, helping to bind together different ingredients that would not normally mix well. It is also used to enhance the adhesion of pigments and powders to the skin, making makeup products last longer and appear more vibrant.
3. Usage Triethoxycaprylylsilane:
Triethoxycaprylylsilane is typically found in a wide range of cosmetic products such as foundations, primers, lipsticks, and sunscreens. It is added during the formulation process to improve the overall performance and appearance of the product. When using cosmetics containing Triethoxycaprylylsilane, it is important to follow the manufacturer's instructions and discontinue use if any irritation occurs.
4. References:
- "Safety Assessment of Triethoxycaprylylsilane as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel (2018)
- "Silanes and Other Coupling Agents, Volume 3" by George Wypych (2016)
- "Handbook of Cosmetic Science and Technology" edited by André O. Barel, Marc Paye, and Howard I. Maibach (2001)
Argania Spinosa Kernel Oil
Other Names: Argan Nut Oil; Argania spinosa Kernel Oil; Argania spinosa Oil
Function: Skin Conditioning, Emollient
1. Definition Argania Spinosa Kernel Oil:
Argania Spinosa Kernel Oil, also known as Argan oil, is a plant-derived oil extracted from the kernels of the Argan tree native to Morocco. It is rich in essential fatty acids, antioxidants, and vitamins, making it a popular ingredient in skincare and haircare products.
2. Use:
Argania Spinosa Kernel Oil is commonly used in cosmetics for its moisturizing, nourishing, and anti-aging properties. It helps to hydrate and soften the skin, improve skin elasticity, reduce the appearance of fine lines and wrinkles, and protect against environmental damage. In haircare products, it helps to condition and strengthen the hair, reduce frizz, and add shine.
3. Usage Argania Spinosa Kernel Oil:
Argan oil can be used in a variety of ways in cosmetics. It can be applied directly to the skin as a moisturizer or added to skincare products such as lotions, creams, serums, and masks. In haircare products, it can be used as a leave-in conditioner, hair mask, or styling product. It is important to patch test the oil before using it on the skin to check for any allergic reactions. It is also recommended to use it sparingly as a little goes a long way.
4. References:
- Schagen, S. K., Zampeli, V. A., Makrantonaki, E., & Zouboulis, C. C. (2012). Discovering the link between nutrition and skin aging. Dermato-endocrinology, 4(3), 298-307.
- Ait Ourhroui, M., Charrouf, Z., Derouiche, A., & Bennani, L. (2017). Argan oil: which benefits on cardiovascular diseases? Trends in Food Science & Technology, 69, 127-133.
- Boucetta, K. Q., Charrouf, Z., Derouiche, A., Rahali, Y., & Bensouda, Y. (2015). Skin hydration in postmenopausal women: Argan oil benefit with oral and/or topical use. Przeglad Menopauzalny = Menopause Review, 14(4), 280-288.
Arginine
Function: Skin Conditioning, Masking, Fragrance, Antistatic Agent, Hair Conditioning
1. Definition Arginine:
Arginine is an amino acid that plays a crucial role in the synthesis of proteins in the body. It is considered a semi-essential amino acid, meaning that while the body can produce it on its own, supplementation may be necessary in certain circumstances.
2. Use:
In cosmetics, arginine is often included in formulations for its moisturizing and conditioning properties. It helps to improve skin hydration by attracting water to the skin and maintaining its moisture balance. Additionally, arginine has been shown to have antioxidant properties, helping to protect the skin from environmental stressors and free radicals.
3. Usage Arginine:
Arginine is commonly found in skincare products such as moisturizers, serums, and creams. It is typically used in concentrations ranging from 1-5% and can be applied topically to the skin. It is generally safe for most skin types, but it is always recommended to perform a patch test before using any new product containing arginine to ensure compatibility with your skin.
4. References:
- Yoon, H. S., Kim, J. R., Park, G. Y., Kim, J. E., Lee, D. H., & Lee, K. W. (2012). Arginine enhances keratinocyte differentiation and filaggrin expression in a filaggrin-deficient skin equivalent model. Biomolecules & therapeutics, 20(3), 292-298.
- Schürer, N., Schliep, V., Williams, J. D., & Imhof, D. (2008). The skin aging exposome. Journal of Drugs in Dermatology, 7(2), s2-s6.
- Kieffer, M. E., & Repka, M. A. (2016). Arginine-based materials for wound healing: State-of-the-art review. Journal of Pharmaceutical Sciences, 105(9), 2675-2686.
Tocopherol
Other Names: Tocopherol; Vit E; vitamin E; α-Tocopherol; Alpha-tocopherol
1. Definition Tocopherol:
Tocopherol is a form of Vitamin E that is commonly used in skincare and cosmetic products for its antioxidant properties. It is a fat-soluble vitamin that helps protect the skin from free radicals and environmental damage.
2. Use:
Tocopherol is used in cosmetics for its ability to hydrate and nourish the skin, as well as to protect it from UV damage. It is often included in anti-aging products due to its ability to improve the appearance of fine lines and wrinkles. Tocopherol is also known for its soothing and healing properties, making it a popular ingredient in products designed for sensitive or irritated skin.
3. Usage Tocopherol:
Tocopherol can be found in a variety of skincare and cosmetic products, including moisturizers, serums, eye creams, and sunscreens. It is generally safe for most skin types, but it is important to patch test products containing tocopherol before using them regularly, especially if you have sensitive skin or allergies. Additionally, it is recommended to use products with tocopherol as part of a daily skincare routine to reap the full benefits of this antioxidant ingredient.
4. References:
- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.
- Draelos, Z. D. (2010). Cosmetic Dermatology: Products and Procedures. Chichester, West Sussex: Wiley-Blackwell.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. Boca Raton, FL: CRC Press.
Bht
Other Names: Di-Butyl Hydroxy Toluene; BHT; Dibutylhydroxytoluene; Butylated hydroxytoluene
Function: Masking, Fragrance, Antioxidant
1. Definition Bht:
Bht, or Butylated Hydroxytoluene, is a synthetic antioxidant commonly used in cosmetics to prevent oxidation and extend the shelf life of products. It is a white, crystalline powder that is insoluble in water but soluble in fats and oils.
2. Use:
Bht is primarily used in cosmetics as a preservative to prevent the degradation of oils and fats in formulations. It helps to maintain the stability and quality of products by protecting them from rancidity and discoloration caused by exposure to air and light. Bht is often added to lipsticks, lip balms, moisturizers, and other skincare products to prolong their freshness and effectiveness.
3. Usage Bht:
When using cosmetics containing Bht, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for topical use in cosmetics, but individuals with sensitive skin or allergies may want to perform a patch test before using products containing Bht. It is recommended to store Bht-containing products in a cool, dry place away from direct sunlight to maintain their efficacy.
4. References:
- Cosmetic Ingredient Review Expert Panel. (1988). Final report on the safety assessment of BHT. International journal of toxicology, 7(5), 669-735.
- Food and Drug Administration. (2021). CFR - Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.110
- National Center for Biotechnology Information. (2021). PubChem Compound Summary for CID 31404, Butylated hydroxytoluene. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylated-hydroxytoluene
Sodium Magnesium Silicate
Function: Viscosity Controlling, Binding Agent, Binding, Bulking Agent
1. Definition Sodium Magnesium Silicate:
Sodium Magnesium Silicate is a naturally occurring mineral derived from clay that is commonly used in cosmetics as a thickening agent, stabilizer, and opacifying agent.
2. Use:
Sodium Magnesium Silicate is used in a variety of cosmetic products such as creams, lotions, and powders to improve texture, enhance stability, and provide a smooth and silky feel to the skin. It is often included in formulations to create a luxurious and velvety finish.
3. Usage Sodium Magnesium Silicate:
When using cosmetics containing Sodium Magnesium Silicate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products with this ingredient to the entire face or body. It is recommended to avoid ingesting products containing Sodium Magnesium Silicate and to keep them out of reach of children.
4. References:
- "Sodium Magnesium Silicate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/sodium-magnesium-silicate.
- Lodeiro, C., et al. "Effect of Sodium Magnesium Silicate on the Rheological and Textural Properties of Cosmetic Emulsions." Journal of Cosmetic Science, vol. 68, no. 1, 2017, pp. 15-24.
- "Safety Assessment of Sodium Magnesium Silicate as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/Sodium%20Magnesium%20Silicate.pdf.
Peg/Ppg 36/41 Dimethyl Ether
Function: Skin Conditioning
1. Definition Peg/Ppg 36/41 Dimethyl Ether:
Peg/Ppg 36/41 Dimethyl Ether is a type of solvent commonly used in cosmetics. It is a mixture of polyethylene glycol (PEG) and polypropylene glycol (PPG) with dimethyl ether. This ingredient is known for its ability to dissolve other substances and improve the texture and consistency of cosmetic products.
2. Use:
Peg/Ppg 36/41 Dimethyl Ether is used in cosmetics as a solvent to help dissolve and mix ingredients together. It can also act as a carrier for other active ingredients, helping them penetrate the skin more effectively. This ingredient is commonly found in skincare products such as lotions, creams, and serums.
3. Usage Peg/Ppg 36/41 Dimethyl Ether:
When using products containing Peg/Ppg 36/41 Dimethyl Ether, it is important to follow the instructions provided by the manufacturer. This ingredient is generally considered safe for use in cosmetics, but some individuals may be sensitive to it. It is recommended to perform a patch test before using a product with this ingredient to check for any adverse reactions. Additionally, it is important to store products containing Peg/Ppg 36/41 Dimethyl Ether in a cool, dry place away from direct sunlight to maintain their efficacy.
4. References:
- ECHA. (2021). "Peg/Ppg 36/41 Dimethyl Ether." European Chemicals Agency. https://echa.europa.eu/
- Cosmeticsinfo.org. (n.d.). "PEG/PPG-36/41 Dimethyl Ether." Personal Care Products Council. https://cosmeticsinfo.org/
- Personal Care Products Council. (2018). "Safety Assessment of PEG/PPG-36/41 Dimethyl Ether and Its Esters as Used in Cosmetics." Cosmetic Ingredient Review.
Mortierella Oil
Other Names: Mortierella isabellina
Function: Skin Conditioning
1. Definition Mortierella Oil:
Mortierella Oil is a type of fungal oil extracted from Mortierella fungi, known for its high content of gamma-linolenic acid (GLA) and other essential fatty acids. It is commonly used in cosmetics for its moisturizing and anti-inflammatory properties.
2. Use:
Mortierella Oil is used in cosmetics as an emollient to hydrate and soften the skin. It is often included in formulations for its ability to improve skin barrier function and reduce inflammation. Additionally, the high GLA content in Mortierella Oil can help to improve skin elasticity and reduce signs of aging.
3. Usage Mortierella Oil:
Mortierella Oil can be found in various skincare products such as moisturizers, serums, and facial oils. It is typically applied to the skin as part of a daily skincare routine, either on its own or mixed with other ingredients. Users should patch test the product before using it extensively to ensure they do not have any allergic reactions. It is recommended to consult with a dermatologist before incorporating Mortierella Oil into your skincare regimen, especially if you have sensitive skin or any existing skin conditions.
4. References:
- Tzu-Kai Lin, Lily Zhong, and Juan Luis Santiago, Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils, International Journal of Molecular Sciences, 2018.
- Y. Nakazawa, et al., Effect of Mortierella alpina oil on the inflammatory responses in dextran sodium sulfate-induced colitis in mice, Prostaglandins, Leukotrienes and Essential Fatty Acids, 2013.
- Y. Lu, et al., Fungal oils, in Lipids in Food and Nutrition, 2008.
Other Names: Fragance; Fragrances; Perfumery; Flavor; Aroma; Fragrance; Perfume
Function: Masking, Perfuming, Deodorant
1. Definition Fragrance:
Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.
2. Use:
Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.
3. Usage Fragrance:
When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.
4. References:
- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.
- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.
- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.
Other Names: Glycerine; Glycerin; Pflanzliches Glycerin; 1,2,3-Propanetriol
Function: Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant
1. Definition Glycerin:
Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.
2. Use:
Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.
3. Usage Glycerin:
When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.
Citronellol
Function: Masking, Fragrance
1. Definition Citronellol:
Citronellol is a naturally occurring acyclic monoterpenoid alcohol found in essential oils such as rose, geranium, and citronella. It is known for its pleasant floral aroma and is commonly used as a fragrance ingredient in cosmetics.
2. Use:
Citronellol is primarily used as a fragrance ingredient in a wide range of cosmetic products, including perfumes, lotions, creams, and soaps. Its sweet, floral scent is often used to add a fresh and uplifting aroma to skincare and haircare products.
3. Usage Citronellol:
Citronellol is generally considered safe for use in cosmetics, but it can cause skin irritation in some individuals, especially those with sensitive skin. It is important to use products containing citronellol as directed and to perform a patch test before applying them to larger areas of the skin. Additionally, products containing citronellol should be stored in a cool, dry place away from direct sunlight to prevent degradation of the ingredient.
4. References:
- Scientific Committee on Consumer Safety (SCCS). (2013). Opinion on citronellol. European Commission.
- Cosmetic Ingredient Review (CIR) Expert Panel. (2008). Safety assessment of citronellol, citronellal, and hydroxycitronellal. International Journal of Toxicology, 27(1), 21-44.
- Fragrance Materials Association. (2019). Citronellol safety assessment. FMA.
Sodium Acetylated Hyaluronate
Other Names: Sodium acetylhyaluronate; Sodium Acetylated Hyaluronate (SHA)
Function: Humectant
1. Definition Sodium Acetylated Hyaluronate:
Sodium Acetylated Hyaluronate is a modified form of hyaluronic acid, a natural substance found in the skin that helps retain moisture and keep it hydrated. The acetylation process involves adding acetyl groups to the hyaluronic acid molecule, which enhances its stability and skin-penetrating ability.
2. Use:
Sodium Acetylated Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and anti-aging properties. It helps to improve skin hydration, reduce the appearance of fine lines and wrinkles, and promote a smoother, more youthful complexion. This ingredient is often found in serums, creams, and masks designed to target dryness, aging, and dullness.
3. Usage Sodium Acetylated Hyaluronate:
When using products containing Sodium Acetylated Hyaluronate, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of the product is applied to clean, dry skin and gently massaged in until fully absorbed. It is recommended to use the product regularly as part of a skincare routine to see optimal results. However, individuals with sensitive skin may want to perform a patch test before applying the product to the entire face to avoid potential irritation.
4. References:
- S. Manju, G. Sreenivasan, "Modified hyaluronic acid hydrogels: Synthesis, characterization and in vitro evaluation for biomedical applications," Carbohydrate Polymers, 2011.
- A. Papakonstantinou, M. Roth, G. Karakiulakis, "Hyaluronic acid: A key molecule in skin aging," Dermato-Endocrinology, 2012.
- A. Oe, Y. Tanihara, T. Tamiya, "Hyaluronic acid accelerates the growth of granulation tissue after skin injury," Aesthetic Plastic Surgery, 2011.
Sodium Hyaluronate
Other Names: Hyaluronic Acid Sodium Salt; Kopuron
Function: Humectant, Skin Conditioning
1. Definition Sodium Hyaluronate:
Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.
2. Use:
Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.
3. Usage Sodium Hyaluronate:
When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.
Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.
4. References:
- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.
- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.
- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.