Differin Adapalene Gel 0.1% Acne Treatment

1. Definition Carbomer 940:

Carbomer 940 is a synthetic polymer used in cosmetics as a thickening agent and emulsifier. It is a white, fluffy powder that swells in water to form a gel-like consistency.

2. Use:

Carbomer 940 is commonly used in skincare products such as lotions, creams, and gels to provide a smooth and thick texture. It helps to stabilize emulsions, improve product consistency, and enhance the spreadability of the product on the skin.

3. Usage Carbomer 940:

When using Carbomer 940 in cosmetics, it is important to follow the recommended usage guidelines provided by the manufacturer. Typically, it is added to the water phase of the formulation and mixed thoroughly to ensure proper dispersion. Overuse of Carbomer 940 can result in a sticky or tacky texture, so it is essential to measure and add the correct amount based on the formulation requirements.

Precautions: It is recommended to wear gloves and protective eyewear when handling Carbomer 940 in its powdered form to avoid irritation or allergic reactions. In case of skin or eye contact, rinse thoroughly with water and seek medical attention if irritation persists. It is also important to store Carbomer 940 in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.

4. References:

- P. D. Coates, M. J. Betts, in Cosmetics Additives, 1995.

- M. A. O'Lenick, in Surfactants in Cosmetics, 2006.

- B. M. Lawrence, in Cosmetics, 1995.

1. Definition Disodium Edta:

Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.

2. Use:

Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.

3. Usage Disodium Edta:

Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.

4. References:

- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/

- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133

1. Definition Methylparaben:

Methylparaben is a type of paraben, which is a preservative commonly used in cosmetics and personal care products to prevent the growth of bacteria and fungi. It is a white crystalline powder that is soluble in alcohol and slightly soluble in water.

2. Use:

Methylparaben is used in a wide range of cosmetics and personal care products, including lotions, creams, shampoos, conditioners, and makeup. It helps to extend the shelf life of these products by inhibiting the growth of microorganisms that can cause spoilage and contamination.

3. Usage Methylparaben:

Methylparaben is typically used at concentrations of 0.1% to 0.5% in cosmetics and personal care products. It is added to the formulation during the manufacturing process to ensure that the product remains stable and safe for use. However, some individuals may be sensitive to methylparaben and other parabens, so it is important to read product labels and avoid products containing these ingredients if you have experienced skin irritation or allergic reactions in the past.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2008). Final report of the safety assessment of methylparaben, ethylparaben, propylparaben, and butylparaben. International Journal of Toxicology, 27(4), 1-82.

- SCCS (Scientific Committee on Consumer Safety). (2011). Opinion on parabens. European Commission, Health & Consumers Directorate-General.

- Soni, M. G., Carabin, I. G., & Burdock, G. A. (2005). Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food and Chemical Toxicology, 43(7), 985-1015.

1. Definition Poloxamer 182:

Poloxamer 182 is a nonionic surfactant that belongs to the family of block copolymers, specifically composed of poly(ethylene oxide) and poly(propylene oxide) blocks. It is commonly used in cosmetics as an emulsifier, solubilizer, and stabilizer due to its ability to improve the texture and consistency of products.

2. Use:

Poloxamer 182 is utilized in cosmetics to create stable emulsions, enhance the solubility of ingredients, and improve the overall performance of formulations. It is often found in creams, lotions, and makeup products to ensure a smooth application and even distribution of active ingredients.

3. Usage Poloxamer 182:

When using products containing Poloxamer 182, it is important to follow the recommended guidelines provided by the manufacturer. It is generally considered safe for topical application, but individuals with sensitive skin may want to perform a patch test before using products with this ingredient extensively. Additionally, avoid contact with eyes and mucous membranes to prevent irritation.

4. References:

- A. Sharma, S. K. Sharma, R. Kumar, "Poloxamers: A pharmaceutical excipients with therapeutic behaviors," International Journal of Pharmaceutical Sciences and Research, vol. 4, no. 1, pp. 249-260, 2013.

- M. M. Bhise, A. S. Patil, S. R. Mahajan, "Poloxamers in pharmaceutical formulations," International Journal of Pharmaceutical Sciences Review and Research, vol. 6, no. 1, pp. 115-122, 2011.

- A. S. Sawant, S. S. Pandit, S. S. Kulkarni, "Poloxamers: A versatile pharmaceutical excipient," World Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 6, pp. 1576-1593, 2017.