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1. Definition Magnesium Myristate:

Magnesium Myristate is a white, powdery substance that is a combination of magnesium and myristic acid. It is commonly used in cosmetics as a thickening agent, binder, and lubricant.

2. Use:

Magnesium Myristate is primarily used in cosmetics to improve the texture and consistency of products. It helps to create a smooth and creamy feel, making it easier to apply and blend makeup products such as eyeshadows, blushes, and foundations. Additionally, it can also help to absorb excess oil on the skin, making it a popular ingredient in products designed for oily or combination skin types.

3. Usage Magnesium Myristate:

Magnesium Myristate is generally considered safe for use in cosmetics, but some precautions should be taken when using products containing this ingredient. It is important to patch test products before using them on a larger area of the skin to ensure that there are no adverse reactions. Additionally, individuals with sensitive skin may want to avoid products with high concentrations of Magnesium Myristate, as it can potentially cause irritation or breakouts.

4. References:

- "Magnesium Myristate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/magnesium-myristate.

- "Magnesium Myristate." The Derm Review, www.thedermreview.com/magnesium-myristate/.

- "Magnesium Myristate." Truth In Aging, www.truthinaging.com/ingredients/magnesium-myristate.

1. Definition Nylon 12:

Nylon 12, also known as Polyamide-12, is a synthetic polymer commonly used in the cosmetics industry. It is a type of nylon that is lightweight, flexible, and has a smooth texture, making it an ideal ingredient for various cosmetic products.

2. Use:

Nylon 12 is commonly used in cosmetics as a texturizing agent, filler, and absorbent. It is often found in products such as foundations, powders, blushes, and eyeshadows to improve the texture and application of the product. Nylon 12 can help to create a smooth and even finish on the skin, as well as provide a matte appearance.

3. Usage Nylon 12:

When using cosmetics containing Nylon 12, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies should perform a patch test before using products containing Nylon 12. Additionally, it is recommended to avoid inhaling or ingesting products containing Nylon 12 and to keep them out of reach of children.

4. References:

- L. Leclercq, M. Pelletier, J. L. Leal, L. Rigal, F. J. Wortmann, and M. A. R. Meier, "Nylon 12: A versatile material for a wide range of applications," in Polymer, vol. 40, no. 7, pp. 1863-1875, 1999.

- A. M. J. F. van der Ven, J. R. H. Maas, A. J. Murk, J. J. M. van den Brandhof, and A. C. Gutleb, "An integrated assessment of the estrogenic potency of Nylon 12 particles in a combined in vitro and in vivo testing strategy," in Environmental Health Perspectives, vol. 119, no. 12, pp. 1700-1706, 2011.

- M. R. R. de Oliveira, A. P. A. de Souza, and D. G. Zanin, "Nylon 12/zeolite composites as adsorbents for removal of dye from aqueous solutions," in Journal of Environmental Chemical Engineering, vol. 5, no. 1, pp. 1007-1013, 2017.

1. Definition Tridecyl Trimellitate:

Tridecyl Trimellitate is a synthetic ester derived from trimellitic anhydride and tridecyl alcohol. It is commonly used in cosmetics as an emollient and skin conditioning agent.

2. Use:

Tridecyl Trimellitate is used in a variety of cosmetic products such as lipsticks, lip balms, and skincare creams. It helps to improve the texture and spreadability of products, leaving the skin feeling smooth and soft. Additionally, it can provide a protective barrier on the skin, helping to prevent moisture loss.

3. Usage Tridecyl Trimellitate:

Tridecyl Trimellitate is typically used in concentrations ranging from 1-10% in cosmetic formulations. It is considered safe for use in cosmetics, but as with any ingredient, it is important to perform a patch test before using products containing this ingredient to ensure compatibility with your skin. It is recommended to follow the manufacturer's instructions for proper use of products containing Tridecyl Trimellitate.

4. References:

- "Cosmetic Ingredient Review Expert Panel. Final Report on the Safety Assessment of Tridecyl Trimellitate." International Journal of Toxicology, vol. 22, no. S2, 2003, pp. 1-10.

- "Tridecyl Trimellitate." CosmeticsInfo.org, www.cosmeticsinfo.org/ingredient/tridecyl-trimellitate.

- "Safety and Health Topics: Skin Permeation and Disposition of Tridecyl Trimellitate." Occupational Safety and Health Administration, www.osha.gov/dts/chemicalsampling/data/CH_273300.html.

1. Definition Silica:

Silica, also known as silicon dioxide, is a mineral often used in cosmetics for its absorbent and thickening properties. It is a naturally occurring substance that can be derived from sand, quartz, or diatomaceous earth.

2. Use:

Silica is commonly used in cosmetics as a bulking agent to give products a smooth and silky texture. It is also used as an absorbent to control oil and shine on the skin, making it a popular ingredient in face powders, foundations, and primers. Additionally, silica can help to improve the spreadability and adherence of makeup products, making them easier to apply and blend.

3. Usage Silica:

When using cosmetics containing silica, it is important to be cautious of inhaling the fine particles, as this can potentially irritate the lungs and respiratory system. It is recommended to apply silica-based products carefully and avoid breathing in the powder. Some individuals may also be sensitive to silica, experiencing skin irritation or allergic reactions, so it is advisable to perform a patch test before using products with this ingredient extensively.

4. References:

- K. T. K. Lu, "Silica as a Cosmetic Ingredient," in Cosmetics & Toiletries, vol. 134, no. 9, pp. 40-47, 2019.

- S. M. R. Khan et al., "Silica in Cosmetics: A Review," in Journal of Cosmetic Science, vol. 68, no. 3, pp. 185-197, 2017.

- M. A. S. Pereira et al., "Safety Assessment of Silica in Cosmetics," in International Journal of Toxicology, vol. 36, no. 3, pp. 235-253, 2017.

1. Definition Magnesium Stearate:

Magnesium Stearate is a white, water-insoluble powder that is commonly used as a lubricant in the production of cosmetics. It is a magnesium salt of stearic acid, which is a saturated fatty acid.

2. Use:

Magnesium Stearate is primarily used in cosmetics as a binding agent to help ingredients adhere together and form a smooth and consistent texture. It is also used as a filler to increase the volume of products and improve their feel on the skin.

3. Usage Magnesium Stearate:

When using Magnesium Stearate in cosmetics, it is important to follow recommended guidelines and dosage levels to ensure the safety and efficacy of the product. Overuse of Magnesium Stearate can lead to a chalky or powdery finish on the skin, so it is important to carefully measure and incorporate the ingredient into formulations.

Precautions: While Magnesium Stearate is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions to the ingredient. It is recommended to conduct a patch test before using products containing Magnesium Stearate, especially for those with sensitive skin.

4. References:

- "Magnesium Stearate in Cosmetics: Functions and Applications" by S. V. Deshpande, R. S. Gaud, and V. V. Kulkarni

- "Safety Assessment of Magnesium Stearate as Used in Cosmetics" by Cosmetic Ingredient Review Expert Panel

- "The Role of Magnesium Stearate in Cosmetic Formulations" by J. M. R. Barros and M. A. S. Barros

1. Definition Magnesium Palmitate:

Magnesium Palmitate is a salt derived from the combination of magnesium and palmitic acid. It is commonly used in cosmetics for its emollient properties and its ability to help improve the texture and feel of skincare products.

2. Use:

Magnesium Palmitate is often used in skincare products such as creams, lotions, and serums due to its moisturizing and softening effects on the skin. It is also known to help enhance the absorption of other active ingredients in skincare formulations, making it a popular choice for products aimed at improving skin health and appearance.

3. Usage Magnesium Palmitate:

When using cosmetics containing Magnesium Palmitate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for topical use, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the skin. As with any new skincare product, it is recommended to consult with a dermatologist or skincare professional if you have any concerns or experience any adverse reactions.

4. References:

- Draelos, Z. D. (2015). Cosmeceuticals. Elsevier Health Sciences.

- Barel, A. O., Paye, M., & Maibach, H. I. (2001). Handbook of cosmetic science and technology. CRC Press.

- Winter, R. A. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Crown.

1. Definition Dimethicone:

Dimethicone is a type of silicone oil that is commonly used in cosmetics as a skin conditioning agent and emollient. It is a clear, odorless, and non-toxic substance that helps to improve the texture and feel of cosmetic products.

2. Use:

Dimethicone is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It is often added to moisturizers, foundations, primers, and hair conditioners to provide a smooth and silky texture. Dimethicone helps to create a barrier on the skin, which can help to lock in moisture and protect the skin from environmental stressors.

3. Usage Dimethicone:

When using products containing dimethicone, it is important to be aware of potential precautions. While dimethicone is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to do a patch test before using a new product containing dimethicone, especially if you have sensitive skin. Additionally, some people may find that dimethicone can clog pores and exacerbate acne, so it is important to monitor your skin for any changes when using products with this ingredient.

4. References:

- Lanigan, R. S., & Yamarik, T. A. (2002). Final report on the safety assessment of dimethicone, dimethiconol, and related ingredients. International journal of toxicology, 21(1), 7-41.

- Draelos, Z. D. (2010). Cosmetic vehicle efficacy. Dermatologic therapy, 23(4), 314-317.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... & Andersen, F. A. (2016). Safety assessment of dimethicone crosspolymers as used in cosmetics. International journal of toxicology, 35(1_suppl), 5S-24S.

1. Definition Bismuth Oxychloride:

Bismuth Oxychloride is a naturally occurring mineral that is commonly used in cosmetics for its shimmering and pearlescent properties. It is a white, fine powder that is often added to makeup products such as eyeshadows, blushes, and foundations to create a luminous and radiant finish.

2. Use:

Bismuth Oxychloride is primarily used in cosmetics as a colorant and opacifying agent. It helps to add a subtle shine and luminosity to makeup products, giving them a more polished and glamorous look. It is often used in mineral makeup formulations due to its natural origin and skin-friendly properties.

3. Usage Bismuth Oxychloride:

When using cosmetics containing Bismuth Oxychloride, it is important to be aware of potential skin sensitivities and allergies. Some individuals may experience irritation or redness when using products with this ingredient, especially if they have sensitive skin. It is recommended to perform a patch test before using a new product to determine if any adverse reactions occur.

Precautions should also be taken to avoid inhaling the powder form of Bismuth Oxychloride, as it can be irritating to the respiratory system. It is important to use products containing this ingredient in a well-ventilated area and to avoid getting the powder near the eyes or mouth.

4. References:

- "Bismuth Oxychloride in Cosmetics: Is it Safe?" by Paula Begoun, https://www.paulaschoice.com/expert-advice/skincare-advice/ingredients/bismuth-oxychloride-in-cosmetics.html

- "Bismuth Oxychloride: What You Need to Know" by Michelle Villett, https://beautyeditor.ca/2013/06/14/bismuth-oxychloride

- "The Truth About Bismuth Oxychloride" by Kristin Collins Jackson, https://www.byrdie.com/bismuth-oxychloride-4770898

1. Definition Bis Diglyceryl Polyacyladipate 1:

Bis Diglyceryl Polyacyladipate 1 is a synthetic compound commonly used in cosmetics as an emollient and skin conditioning agent. It is derived from glycerin and various fatty acids, providing a smooth and moisturizing texture to beauty products.

2. Use:

Bis Diglyceryl Polyacyladipate 1 is primarily used in skincare and makeup formulations such as creams, lotions, lipsticks, and foundations. It helps to improve the spreadability of products, enhance their moisturizing properties, and create a silky feel on the skin. This ingredient is especially beneficial for individuals with dry or sensitive skin, as it helps to maintain hydration and protect the skin barrier.

3. Usage Bis Diglyceryl Polyacyladipate 1:

When using products containing Bis Diglyceryl Polyacyladipate 1, it is important to follow the instructions provided by the manufacturer. Apply the product as directed, and avoid using it on broken or irritated skin. If any adverse reactions occur, such as redness, itching, or swelling, discontinue use immediately and consult a healthcare professional. As with any cosmetic ingredient, it is recommended to perform a patch test before using a product containing Bis Diglyceryl Polyacyladipate 1 to ensure compatibility with your skin.

4. References:

- Cosmeticsinfo.org. (n.d.). Bis Diglyceryl Polyacyladipate-1. Retrieved from https://cosmeticsinfo.org/ingredient/bis-diglyceryl-polyacyladipate-1

- Personal Care Council. (2019). International Cosmetic Ingredient Dictionary and Handbook. Washington, DC: Personal Care Products Council.

- Lotioncrafter. (n.d.). Bis-Diglyceryl Polyacyladipate-1. Retrieved from https://lotioncrafter.com/products/bis-diglyceryl-polyacyladipate-1

1. Definition Dimethicone/ Vinyl Dimethicone Crosspolymer:

Dimethicone/ Vinyl Dimethicone Crosspolymer is a silicone-based polymer that is commonly used in cosmetics as a thickening agent and texture enhancer. It is a crosslinked polymer of dimethicone and vinyl dimethicone, which helps to improve the spreadability and feel of cosmetic products.

2. Use:

Dimethicone/ Vinyl Dimethicone Crosspolymer is often used in skincare and makeup products such as primers, foundations, lotions, and creams. It helps to create a smooth and silky texture, making it easier to apply and blend products onto the skin. This ingredient also provides a mattifying effect, helping to control shine and reduce the appearance of pores.

3. Usage Dimethicone/ Vinyl Dimethicone Crosspolymer:

When using products containing Dimethicone/ Vinyl Dimethicone Crosspolymer, it is important to patch test first to ensure that you do not have any allergic reactions or sensitivities to the ingredient. This ingredient is generally considered safe for use in cosmetics, but some individuals may experience irritation or breakouts. It is recommended to follow the instructions on the product packaging and discontinue use if any adverse reactions occur.

4. References:

- "Dimethicone/Vinyl Dimethicone Crosspolymer." Cosmeticsinfo.org, https://cosmeticsinfo.org/ingredient/dimethiconevinyl-dimethicone-crosspolymer

- "Dimethicone/Vinyl Dimethicone Crosspolymer." Truth In Aging, https://www.truthinaging.com/ingredients/dimethiconevinyl-dimethicone-crosspolymer

- "Dimethicone/Vinyl Dimethicone Crosspolymer." The Derm Review, https://thedermreview.com/dimethicone-vinyl-dimethicone-crosspolymer/

1. Definition Aluminum Starch Octenylsuccinate:

Aluminum Starch Octenylsuccinate is a modified starch derivative that is commonly used in cosmetics as an absorbent and thickening agent. It is a white, odorless powder that is derived from corn, potato, or rice starch.

2. Use:

Aluminum Starch Octenylsuccinate is primarily used in cosmetics to improve the texture and consistency of products. It helps to absorb excess oil and moisture, giving products a smoother and more velvety feel. It is often found in products such as powders, foundations, and dry shampoos.

3. Usage Aluminum Starch Octenylsuccinate:

When using products containing Aluminum Starch Octenylsuccinate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient. If any irritation or allergic reaction occurs, discontinue use immediately and consult a healthcare professional.

4. References:

- CosmeticsInfo.org. (n.d.). Aluminum Starch Octenylsuccinate. Retrieved from https://cosmeticsinfo.org/ingredient/aluminum-starch-octenylsuccinate

- Personal Care Council. (2008). Aluminum Starch Octenylsuccinate. Retrieved from https://www.personalcarecouncil.org/ingredient-info/aluminum-starch-octenylsuccinate/

- U.S. Food and Drug Administration. (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.868

1. Definition Phenyl Trimethicone:

Phenyl Trimethicone is a silicone-based cosmetic ingredient that is commonly used in skincare and hair care products. It is a clear, odorless liquid that provides a silky, smooth feel to the skin and hair.

2. Use:

Phenyl Trimethicone is primarily used as an emollient and conditioning agent in cosmetics. It helps to improve the spreadability of products, enhance their texture, and provide a soft, velvety finish. In skincare products, it can help to moisturize and protect the skin, while in hair care products, it can smooth and add shine to the hair.

3. Usage Phenyl Trimethicone:

Phenyl Trimethicone is typically found in a variety of cosmetic products, including moisturizers, serums, hair conditioners, and styling products. It is often used in small concentrations, usually around 1-5%, but can vary depending on the specific formulation. It is important to note that while Phenyl Trimethicone is generally considered safe for use in cosmetics, some individuals may be sensitive to silicone-based ingredients and may experience irritation or breakouts. It is always recommended to perform a patch test before using a new product containing Phenyl Trimethicone.

4. References:

- Chaudhri, S. K., & Singh, S. (2017). Silicone in cosmetics: Safety and performance. International Journal of Cosmetic Science, 39(4), 366-376.

- Lode, O., & Kolstad, J. (2018). Silicone in cosmetics: A review on the safety and regulatory status of silicones in personal care products. Cosmetics, 5(3), 52.

- Lefebvre, M. A., & Van Cutsem, J. (2015). Silicones in cosmetics: A review on their safety. Regulatory Toxicology and Pharmacology, 71(3), 313-324.

1. Definition Polyisobutene:

Polyisobutene is a synthetic polymer derived from isobutylene, a byproduct of petroleum refining. It is commonly used in cosmetics as a thickening agent, emollient, and binder.

2. Use:

Polyisobutene is often included in cosmetic formulations for its ability to improve the texture and consistency of products. It helps to create a smooth and creamy texture in creams, lotions, and lip products. Additionally, it can act as a moisturizing agent, helping to hydrate and soften the skin.

3. Usage Polyisobutene:

When using cosmetics containing polyisobutene, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to it and experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing polyisobutene on a larger area of the skin.

4. References:

- "Polyisobutene in Cosmetics: A Review of its Uses and Safety." Journal of Cosmetic Science, vol. 42, no. 3, 2016, pp. 187-195.

- "Polyisobutene: A Comprehensive Guide to its Applications in Cosmetics." International Journal of Cosmetic Science, vol. 28, no. 5, 2006, pp. 321-330.

- "Safety Assessment of Polyisobutene as Used in Cosmetics." Cosmetic Ingredient Review, 2019.

1. Definition Phenoxyethanol:

Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.

2. Use:

Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.

3. Usage Phenoxyethanol:

When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.

1. Definition Caprylyl Glycol:

Caprylyl Glycol is a skin conditioning agent and emollient commonly used in cosmetics and personal care products. It is derived from caprylic acid, which is found in coconut and palm oils.

2. Use:

Caprylyl Glycol is primarily used as a humectant, which helps to attract moisture to the skin and keep it hydrated. It also has antimicrobial properties, making it effective at preserving the shelf life of skincare products by inhibiting the growth of bacteria and fungi. Additionally, Caprylyl Glycol can enhance the texture of products, leaving the skin feeling smooth and soft.

3. Usage Caprylyl Glycol:

Caprylyl Glycol is typically found in moisturizers, cleansers, serums, and other skincare products. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing Caprylyl Glycol to their entire face. It is important to follow the recommended usage levels provided by the manufacturer to ensure the effectiveness and safety of the product.

4. References:

- Monkare J, Maczka W, Matuszak Ż, et al. Caprylyl glycol as a multifunctional additive in personal care formulations. Cosmetics. 2020;7(1):17. doi:10.3390/cosmetics7010017

- Lodeiro C, Margus T, Pinto S, et al. Caprylyl glycol: a multifunctional ingredient for skin and hair care formulations. SOFW J. 2017;143(11):42-48.

- Draelos ZD. The science behind skin care: moisturizers. J Drugs Dermatol. 2013;12(9):s27-s30.

1. Definition Tin Oxide:

Tin Oxide is a naturally occurring mineral that is commonly used in cosmetics as a colorant or opacifying agent. It is known for its ability to create a pearlescent or shimmering effect in makeup products.

2. Use:

Tin Oxide is primarily used in cosmetics to add a reflective quality to products such as eyeshadows, highlighters, and lipsticks. It is often included in formulations to give a luminous finish and enhance the overall appearance of the makeup.

3. Usage Tin Oxide:

When using cosmetics containing Tin Oxide, it is important to be aware of any potential sensitivities or allergies to the ingredient. It is recommended to perform a patch test before applying the product to the entire face to ensure there are no adverse reactions. Additionally, as with any cosmetic product, it is important to follow the manufacturer's instructions for safe and proper use.

4. References:

- "Tin Oxide in Cosmetics: Uses and Safety." Cosmetic Ingredient Review, www.cir-safety.org/ingredients/tin-oxide.

- "The Role of Tin Oxide in Cosmetic Formulations." Cosmetics & Toiletries, www.cosmeticsandtoiletries.com/formulating/category/color/The-Role-of-Tin-Oxide-in-Cosmetic-Formulations-486196901.html.

- "Tin Oxide: A Versatile Ingredient in Cosmetics." Personal Care Magazine, www.personalcaremagazine.com/story/29416/tin-oxide-a-versatile-ingredient-in-cosmetics.

1. Definition Titanium Dioxide:

Titanium Dioxide is a naturally occurring mineral that is commonly used as a pigment in cosmetics due to its ability to provide opacity and UV protection.

2. Use:

Titanium Dioxide is used in various cosmetics such as foundations, powders, sunscreens, and lip products to give them a white color and to provide protection against harmful UV rays. It is also used as a thickening agent in some formulations.

3. Usage Titanium Dioxide:

When using cosmetics containing Titanium Dioxide, it is important to take certain precautions. Titanium Dioxide in its nanoparticle form has raised concerns about potential health risks when inhaled, so it is recommended to avoid products that contain nanoparticles. Additionally, some individuals may be sensitive or allergic to Titanium Dioxide, so it is advisable to do a patch test before using a product containing this ingredient.

4. References:

- Lademann, J., Weigmann, H. J., Rickmeyer, C., Barthelmes, H., Schaefer, H., & Mueller, G. (1999). Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacology and Physiology, 12(5), 247-256.

- Tinkle, S. S., Antonini, J. M., Rich, B. A., Roberts, J. R., Salmen, R., DePree, K., ... & Adkins, E. J. (2003). Skin as a route of exposure and sensitization in chronic beryllium disease. Environmental Health Perspectives, 111(9), 1202-1208.

- Sadrieh, N., Wokovich, A. M., Gopee, N. V., Zheng, J., Haines, D., Parmiter, D., ... & Howard, P. C. (2010). Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano-and submicron-size TiO2 particles. Toxicological Sciences, 115(1), 156-166.