Name: Evidence Skin Care Complexion Correction: Microneedle Patches
Brand: Evidence Skin Care
Rating: 5 (6 reviews)

Sodium Hyaluronate

Other Names: Hyaluronic Acid Sodium Salt; Kopuron

Function: Humectant, Skin Conditioning

1. Definition Sodium Hyaluronate:

Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.

2. Use:

Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.

3. Usage Sodium Hyaluronate:

When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.

Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.

4. References:

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

Niacinamide

Other Names: Nicotinic acid amide; Nicotinamide

Function: Hair Conditioning, Skin Conditioning, Smoothing

1. Definition Niacinamide:

Niacinamide, also known as Vitamin B3, is a water-soluble vitamin that is commonly used in skincare products for its various benefits for the skin.

2. Use:

Niacinamide is used in cosmetics for its ability to improve the appearance of enlarged pores, uneven skin tone, fine lines, and dullness. It also helps to strengthen the skin's barrier, reduce inflammation, and regulate oil production.

3. Usage Niacinamide:

Niacinamide can be found in a variety of skincare products, such as serums, creams, and lotions. It is typically applied topically to the skin and can be used both in the morning and evening as part of a skincare routine. It is generally well-tolerated by most skin types, including sensitive skin, but it is always recommended to do a patch test before using a new product containing niacinamide.

Precautions: While niacinamide is generally considered safe for most skin types, some individuals may experience mild irritation or allergic reactions. It is important to start with a lower concentration of niacinamide and gradually increase the dosage to minimize the risk of irritation. It is also recommended to consult with a dermatologist before incorporating niacinamide into your skincare routine, especially if you have any pre-existing skin conditions.

4. References:

- Schagen, S. K., Zampeli, V. A., Makrantonaki, E., & Zouboulis, C. C. (2012). Discovering the link between nutrition and skin aging. Dermato-endocrinology, 4(3), 298-307.

- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery, 31(7), 860-865.

- Draelos, Z. D. (2005). The latest cosmeceutical approaches for anti-aging. Journal of Cosmetic Dermatology, 4(4), 273-278.

Ascorbyl Tetraisopalmitate

Other Names: VC-IP; Tetrahexyldecyl Ascorbate; Vitamin C Tetraisopalmitate

Function: Skin Conditioning, Emollient, Antioxidant

1. Definition Ascorbyl Tetraisopalmitate:

Ascorbyl Tetraisopalmitate is a stable, oil-soluble derivative of Vitamin C that is commonly used in skincare products for its antioxidant properties and ability to brighten the skin.

2. Use:

Ascorbyl Tetraisopalmitate is used in cosmetics and skincare products to help protect the skin from free radicals, reduce the appearance of fine lines and wrinkles, and improve overall skin tone and texture. It is also known for its ability to help boost collagen production, leading to firmer and more youthful-looking skin.

3. Usage Ascorbyl Tetraisopalmitate:

Ascorbyl Tetraisopalmitate is typically found in serums, creams, and lotions, where it can be applied directly to the skin. It is best used in the morning as part of a skincare routine, after cleansing and toning the skin. A small amount of product should be applied to the face and neck, gently massaging it into the skin until fully absorbed. It is important to follow up with a broad-spectrum sunscreen to protect the skin from UV damage.

4. References:

- Choi, S. Y., Lee, S. N., Lee, M. J., Kim, Y. C., & Choe, Y. B. (2009). Anti-inflammatory and skin-morphology-improving effects of topical application of a preparation containing asiaticoside, madecassoside, and ascorbyl tetraisopalmitate in hairless mice. Annals of dermatology, 21(1), 70-77.

- Lin, F. H., Lin, J. Y., Gupta, R. D., Tournas, J. A., Burch, J. A., Selim, M. A., ... & Fisher, G. J. (2005). Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. Journal of Investigative Dermatology, 125(4), 826-832.

- Telang, P. S. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143.

Green Tea

Function: Skin Conditioning, Masking, Emollient, Fragrance, Humectant, Antimicrobial, Skin Protecting, Uv Absorber, Antioxidant, Tonic, Astringent, Skin-Conditioning Agent -Miscellaneous

1. Definition Camellia Sinensis (Green Tea):

Camellia Sinensis, commonly known as green tea, is a plant species native to East Asia, specifically China and Japan. It is widely cultivated for its leaves, which are used to produce various types of tea, including green tea, black tea, white tea, and oolong tea. Green tea is known for its high levels of antioxidants, particularly catechins, which have been linked to numerous health benefits.

2. Use:

Green tea extract is used in cosmetics for its antioxidant properties, which help protect the skin from damage caused by free radicals. It is also known for its anti-inflammatory and anti-aging properties, making it a popular ingredient in skincare products. Green tea can help reduce redness and irritation, improve skin tone and texture, and minimize the appearance of fine lines and wrinkles.

3. Usage Camellia Sinensis (Green Tea):

Green tea extract can be found in a variety of cosmetic products, including moisturizers, serums, masks, and eye creams. When using products containing green tea extract, it is important to follow the instructions provided by the manufacturer. As with any new skincare product, it is recommended to perform a patch test before using it on a larger area of skin to check for any potential allergic reactions or sensitivities.

4. References:

- Katiyar, S. K. (2011). Skin photoprotection by green tea: antioxidant and immunomodulatory effects. Current Drug Targets, 12(11), 1710-1719.

- Hsu, S. (2005). Green tea and the skin. Journal of the American Academy of Dermatology, 52(6), 1049-1059.

- Boehm, K., Borrelli, F., Ernst, E., Habacher, G., Hung, S. K., Milazzo, S., ... & Horneber, M. (2009). Green tea (Camellia sinensis) for the prevention of cancer. Cochrane Database of Systematic Reviews, (3).

4 Butylresorcinol

Function: Antioxidant

1. Definition 4 Butylresorcinol:

4 Butylresorcinol is a synthetic compound that belongs to the family of resorcinols, which are commonly used in cosmetics for their skin-lightening and antioxidant properties. It is a white, crystalline powder that is soluble in alcohol and ether.

2. Use:

4 Butylresorcinol is primarily used in cosmetics as a skin-lightening agent to help reduce the appearance of hyperpigmentation, dark spots, and uneven skin tone. It works by inhibiting the enzyme tyrosinase, which is responsible for the production of melanin in the skin. Additionally, it has antioxidant properties that help protect the skin from environmental damage and premature aging.

3. Usage 4 Butylresorcinol:

When using cosmetics containing 4 Butylresorcinol, it is important to follow the manufacturer's instructions carefully. It is typically recommended to apply the product to clean, dry skin and to avoid contact with the eyes and mucous membranes. It is also advisable to use sunscreen during the day to protect the skin from further pigmentation and sun damage. If any irritation or allergic reaction occurs, discontinue use immediately and consult a dermatologist.

4. References:

- Kim, S. J., Kim, Y. K., Cho, S., & Cho, S. (2012). Comparative study of the effects of 4-n-butylresorcinol and hydroquinone on senile lentigines in Asians. Journal of cosmetic and laser therapy, 14(5), 230-234.

- Lee, H. J., Lee, J. H., Kim, T. H., Lee, J. Y., & Lee, A. Y. (2013). A comparative study of the effects of 4-n-butylresorcinol and hydroquinone on facial hyperpigmentation. Annals of dermatology, 25(4), 454-461.

- Wu, Y., Li, W., Xu, Y., Jin, E., Tu, Y., & Qin, T. J. (2017). Efficacy and safety of 4-n-butylresorcinol 0.3% cream for the treatment of melasma: A randomized, double-blind, placebo-controlled pilot study. Journal of cosmetic dermatology, 16(1), 89-94.

Retinal

Other Names: Retinaldehyde; Vitamin A aldehyde

Function: Skin Conditioning

1. Definition Retinal:

Retinal, also known as retinaldehyde, is a form of Vitamin A that is commonly used in skincare products for its anti-aging and skin-renewing properties. It is a precursor to retinoic acid, a compound that is known for its ability to improve skin texture, reduce the appearance of fine lines and wrinkles, and promote collagen production.

2. Use:

Retinal is often used in cosmetics to address various skin concerns, including signs of aging, uneven skin tone, and acne. It is a potent ingredient that can help to improve the overall health and appearance of the skin by promoting cell turnover and stimulating collagen production. Retinal is also known for its antioxidant properties, which can help to protect the skin from damage caused by free radicals and environmental stressors.

3. Usage Retinal:

When using skincare products containing retinal, it is important to follow the instructions provided by the manufacturer. Retinal can be a potent ingredient, so it is recommended to start with a lower concentration and gradually increase the frequency of use as tolerated. It is also important to use sunscreen during the day when using retinal, as it can increase the skin's sensitivity to the sun.

Precautions: Some individuals may experience mild irritation or sensitivity when using products containing retinal. It is important to monitor the skin for any signs of irritation and discontinue use if any adverse reactions occur. It is also recommended to consult with a dermatologist before incorporating retinal into your skincare routine, especially if you have sensitive skin or are pregnant.

4. References:

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327–348.

- Draelos, Z. D. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327–348.

Resveratrol

Function: Skin Protecting, Antioxidant

1. Definition Resveratrol:

Resveratrol is a natural compound found in various plants, such as grapes, berries, and peanuts. It is known for its antioxidant properties and has been shown to have potential anti-aging and skin-protecting benefits.

2. Use:

Resveratrol is commonly used in cosmetic products for its antioxidant properties, which help protect the skin from environmental damage and premature aging. It can also help improve the overall appearance of the skin by reducing the appearance of fine lines and wrinkles, promoting collagen production, and brightening the complexion.

3. Usage Resveratrol:

When using products containing Resveratrol, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin. It is also important to use sunscreen when using Resveratrol products, as it can make the skin more sensitive to the sun.

4. References:

- Lin, J.K., Lin-Shiau, S.Y., & Juan, I.M. (2003). Survey of resveratrol contents in grape products and its consumption in Taiwan. Journal of Food and Drug Analysis, 11(2), 177-183.

- Sharma, S., & Anand, S. (2018). Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies. Anticancer Agents in Medicinal Chemistry, 18(13), 1850-1861.

- Fauconneau, B., Waffo-Teguo, P., Huguet, F., Barrier, L., Decendit, A., & Merillon, J.M. (1997). Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vinifera cell cultures using in vitro tests. Life Sciences, 61(21), 2103-2110.

Ferulic Acid

Function: Preservative, Uv Absorber, Antioxidant, Antimicrobial

1. Definition Ferulic Acid:

Ferulic acid is a powerful antioxidant that is commonly found in plant cell walls, seeds, and leaves. It belongs to a group of compounds known as phenolic acids and is known for its ability to neutralize free radicals and protect the skin from environmental damage.

2. Use:

Ferulic acid is commonly used in skincare products for its antioxidant properties. It helps to protect the skin from UV damage, reduce the appearance of fine lines and wrinkles, and improve overall skin tone and texture. Ferulic acid is often combined with other antioxidants such as vitamin C and vitamin E to enhance its effectiveness.

3. Usage Ferulic Acid:

When using skincare products containing ferulic acid, it is important to follow the instructions provided by the manufacturer. Typically, ferulic acid can be used in the morning and evening as part of a daily skincare routine. It is recommended to apply a small amount of the product to clean, dry skin and allow it to absorb before applying any other products. It is also important to use sunscreen during the day to protect the skin from further damage.

4. References:

- Tan, B. J., Liu, Y., & Chang, K. L. (2019). Ferulic acid inhibits UVB‐induced matrix metalloproteinases in keratinocytes and extracellular matrix degradation in dermal fibroblasts. Journal of Cellular and Molecular Medicine, 23(1), 547-556.

- Saraf, S., & Mishra, D. (2010). Ferulic acid: therapeutic potential through its antioxidant property. Journal of Clinical Biochemistry and Nutrition, 48(2), 89-99.

- Zuo, L., Shiah, A., & Roberts, J. (2008). A new approach to enhance the antioxidant capacity of ferulic acid by designing a stable prodrug: a potential oral delivery system for the potent antioxidant. Journal of Medicinal Chemistry, 51(9), 2542-2550.

EWG	CIR	Ingredient Name & Cosmetic Function	Notes
1	A	Sodium Hyaluronate (Humectant, Skin Conditioning)	Good for dry skin Promotes Wound Healing
1	A	Niacinamide (Hair Conditioning, Skin Conditioning, Smoothing)	Anti Aging Brightening
1	-	Ascorbyl Tetraisopalmitate (Skin Conditioning, Emollient, Antioxidant)	Brightening Fungal Acne Trigger
1	-	Green Tea (Skin Conditioning, Masking, Emollient, Fragrance, Humectant, Antimicrobial, Skin Protecting, Uv Absorber, Antioxidant, Tonic, Astringent, Skin-Conditioning Agent -Miscellaneous)	Moisturizing
1	-	4 Butylresorcinol (Antioxidant)
5 6	-	Retinal (Skin Conditioning)
1	-	Resveratrol (Skin Protecting, Antioxidant)	Moisturizing
1 2	-	Ferulic Acid (Preservative, Uv Absorber, Antioxidant, Antimicrobial)	Anti Aging

Evidence Skin Care Complexion Correction: Microneedle Patches

Ingredients

Analysis results of Ingredients

Ingredient List