Name: glenmark Klenzit-C Adapalene Clindamycin Phosphate gel
Brand: glenmark
Rating: 5 (6 reviews)

Adapalene

Other Names: Adaplene; Differin

Function: Antiacne Agent

1. Definition Adapalene:

Adapalene is a synthetic compound that belongs to the class of medications known as retinoids. It is commonly used in the treatment of acne, as it helps to unclog pores, reduce inflammation, and promote skin cell turnover.

2. Use:

Adapalene is primarily used in the formulation of topical treatments for acne, such as gels, creams, and lotions. It is known for its ability to target multiple factors that contribute to acne formation, making it a popular choice among dermatologists and skincare professionals.

3. Usage Adapalene:

When using products containing Adapalene, it is important to follow the instructions provided by a healthcare professional or included on the product packaging. Typically, Adapalene should be applied to clean, dry skin once daily, preferably in the evening. It is important to avoid excessive sun exposure while using Adapalene, as it can increase the skin's sensitivity to UV radiation. Additionally, some individuals may experience mild irritation or dryness when first using Adapalene, but these side effects usually subside with continued use.

4. References:

- Dreno, B., Thiboutot, D., Gollnick, H., Finlay, A.Y., Layton, A., Leyden, J.J., & Kang, S. (2009). Large-scale worldwide observational study of adherence with acne therapy. International Journal of Dermatology, 48(7), 749-756.

- Thielitz, A., Gollnick, H., & Reinhold, D. (2008). Adapalene as a treatment for acne vulgaris: a retrospective analysis of data from the German Acne Registry. Journal of the European Academy of Dermatology and Venereology, 22(6), 787-794.

- Leyden, J.J., Wortzman, M., & Baldwin, E.K. (2011). A single-center, randomized double-blind, parallel-group study to examine the safety and efficacy of 0.1% Adapalene gel compared to vehicle in the treatment of acne vulgaris in adult females. Journal of Drugs in Dermatology, 10(6), 582-587.

Clindamycin Phosphate

Ingredient data is being updated. Please check back later.

Disodium Edta

Other Names: Endrate; Disodium Edetate; Disodium Salt; Disodium EDTA; Disodium dihydrogen ethylenediaminetetraacetate; EDTA Disodium Salt; EDTA-2Na

Function: Chelating Agent, Viscosity Controlling

1. Definition Disodium Edta:

Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.

2. Use:

Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.

3. Usage Disodium Edta:

Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.

4. References:

- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/

- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133

Carbomer 940

Function: Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Gel Forming

1. Definition Carbomer 940:

Carbomer 940 is a synthetic polymer used in cosmetics as a thickening agent and emulsifier. It is a white, fluffy powder that swells in water to form a gel-like consistency.

2. Use:

Carbomer 940 is commonly used in skincare products such as lotions, creams, and gels to provide a smooth and thick texture. It helps to stabilize emulsions, improve product consistency, and enhance the spreadability of the product on the skin.

3. Usage Carbomer 940:

When using Carbomer 940 in cosmetics, it is important to follow the recommended usage guidelines provided by the manufacturer. Typically, it is added to the water phase of the formulation and mixed thoroughly to ensure proper dispersion. Overuse of Carbomer 940 can result in a sticky or tacky texture, so it is essential to measure and add the correct amount based on the formulation requirements.

Precautions: It is recommended to wear gloves and protective eyewear when handling Carbomer 940 in its powdered form to avoid irritation or allergic reactions. In case of skin or eye contact, rinse thoroughly with water and seek medical attention if irritation persists. It is also important to store Carbomer 940 in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.

4. References:

- P. D. Coates, M. J. Betts, in Cosmetics Additives, 1995.

- M. A. O'Lenick, in Surfactants in Cosmetics, 2006.

- B. M. Lawrence, in Cosmetics, 1995.

Propylene Glycol

Other Names: Monopropylene Glycol; Propyl Glycol; 1,2-Dihydroxypropane; 1,2-Propanediol; Propane-1,2-diol; 1,2-Propylene Glycol

Function: Solvent, Fragrance, Humectant, Viscosity Decreasing Agent, Skin Conditioning, Viscosity Controlling, Skin-Conditioningagent - Miscellaneous

1. Definition Propylene Glycol:

Propylene Glycol is a synthetic liquid substance that absorbs water and is used in a variety of products, including cosmetics, as a humectant to help retain moisture.

2. Use:

Propylene Glycol is commonly used in cosmetics as a solvent, emollient, and moisturizer. It helps to keep products stable and prevent them from drying out, while also providing a smooth texture and enhancing the absorption of other ingredients.

3. Usage Propylene Glycol:

When using cosmetics containing Propylene Glycol, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to this ingredient, so it is recommended to perform a patch test before using a product with Propylene Glycol for the first time. Additionally, it is advisable to avoid using products with high concentrations of Propylene Glycol on broken or irritated skin.

4. References:

- "Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel

- "Propylene Glycol" by the Environmental Working Group

- "Propylene Glycol in Cosmetics" by the Personal Care Products Council

Methylparaben

Other Names: Methyl Paraben; Methyl Parahydroxybenzoate; Methyl p-hydroxybenzoate; Nipagin M; Methyl Hydroxybenzoate; Methyl 4-hydroxybenzoate

Function: Fragrance, Preservative

1. Definition Methylparaben:

Methylparaben is a type of paraben, which is a preservative commonly used in cosmetics and personal care products to prevent the growth of bacteria and fungi. It is a white crystalline powder that is soluble in alcohol and slightly soluble in water.

2. Use:

Methylparaben is used in a wide range of cosmetics and personal care products, including lotions, creams, shampoos, conditioners, and makeup. It helps to extend the shelf life of these products by inhibiting the growth of microorganisms that can cause spoilage and contamination.

3. Usage Methylparaben:

Methylparaben is typically used at concentrations of 0.1% to 0.5% in cosmetics and personal care products. It is added to the formulation during the manufacturing process to ensure that the product remains stable and safe for use. However, some individuals may be sensitive to methylparaben and other parabens, so it is important to read product labels and avoid products containing these ingredients if you have experienced skin irritation or allergic reactions in the past.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2008). Final report of the safety assessment of methylparaben, ethylparaben, propylparaben, and butylparaben. International Journal of Toxicology, 27(4), 1-82.

- SCCS (Scientific Committee on Consumer Safety). (2011). Opinion on parabens. European Commission, Health & Consumers Directorate-General.

- Soni, M. G., Carabin, I. G., & Burdock, G. A. (2005). Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food and Chemical Toxicology, 43(7), 985-1015.

Phenoxyethanol

Other Names: Phenoxethol; 2-phenoxyethanol; Ethylene glycol monophenyl ether; Phenyl cellosolve; Protectol PE

Function: Fragrance, Preservative

1. Definition Phenoxyethanol:

Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.

2. Use:

Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.

3. Usage Phenoxyethanol:

When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.

Poloxamer 407

Function: Emulsifying, Surfactant

1. Definition Poloxamer 407:

Poloxamer 407, also known as Pluronic F127, is a non-ionic surfactant that is commonly used in the pharmaceutical and cosmetic industries. It is a block copolymer composed of polyethylene oxide and polypropylene oxide, which gives it unique properties such as solubilizing, emulsifying, and stabilizing abilities.

2. Use:

Poloxamer 407 is widely used in cosmetics as an emulsifier, stabilizer, and solubilizer. It helps to create stable emulsions, improve the texture of products, and enhance the solubility of active ingredients. It is commonly found in creams, lotions, and gels, where it helps to improve the overall performance and appearance of the product.

3. Usage Poloxamer 407:

When using products containing Poloxamer 407, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product containing Poloxamer 407, especially if you have sensitive skin. Additionally, it is important to avoid contact with the eyes and mucous membranes.

4. References:

- Kim, J. W., Lee, J. E., & Kim, J. O. (2019). Development of a cosmetic patch containing poloxamer 407 for skin moisturization. International Journal of Cosmetic Science, 41(2), 167-173.

- Almeida, H., Amaral, M. H., Lobao, P., & Sousa Lobo, J. M. (2017). Applications of poloxamers in ophthalmic pharmaceutical formulations: an overview. Expert Opinion on Drug Delivery, 14(9), 1163-1176.

- Sivakumar, M., Tang, S. Y., Tan, K. W., & Chua, K. H. (2016). Biocompatibility study of poloxamer-based hydrogel as a cell carrier. Biomedical Materials, 11(4), 045006.

Sodium Hydroxide

Other Names: NaOH

Function: Denaturant , pH adjusting agent, pH adjusting agent

1. Definition Sodium Hydroxide:

Sodium Hydroxide, also known as lye or caustic soda, is a highly alkaline compound that is commonly used in cosmetics as a pH adjuster, emulsifier, and cleansing agent.

2. Use:

Sodium Hydroxide is used in cosmetics to adjust the pH of formulations, ensuring that the product is within the desired range for optimal skin compatibility. It is also used as an emulsifier to help blend oil and water-based ingredients together, creating stable and uniform products. Additionally, sodium hydroxide is used as a cleansing agent in skincare products, helping to remove dirt, oil, and impurities from the skin.

3. Usage Sodium Hydroxide:

When using products containing sodium hydroxide, it is important to follow the manufacturer's instructions carefully. Avoid direct contact with the eyes, as it can cause irritation or burns. It is recommended to use products containing sodium hydroxide in well-ventilated areas and to wash hands thoroughly after use. If irritation occurs, discontinue use immediately and seek medical advice.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2013). Final report on the safety assessment of sodium hydroxide. International Journal of Toxicology, 32(1), 59S-80S.

- Personal Care Products Council. (2020). Sodium Hydroxide. Retrieved from https://www.personalcarecouncil.org/ingredient-info/sodium-hydroxide/

- National Center for Biotechnology Information. (2021). Sodium Hydroxide. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-hydroxide

Distilled Water

Ingredient data is being updated. Please check back later.

EWG	CIR	Ingredient Name & Cosmetic Function	Notes
-	-	Adapalene (Antiacne Agent)	Acne fighting
-	-	Clindamycin Phosphate
1	A	Disodium Edta (Chelating Agent, Viscosity Controlling)
1	A	Carbomer 940 (Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Gel Forming)
3	B	Propylene Glycol (Solvent, Fragrance, Humectant, Viscosity Decreasing Agent, Skin Conditioning, Viscosity Controlling, Skin-Conditioningagent - Miscellaneous)	Good for dry skin
3 4	A	Methylparaben (Fragrance, Preservative)	Paraben
2 4	A	Phenoxyethanol (Fragrance, Preservative)
2	A	Poloxamer 407 (Emulsifying, Surfactant)	Cleansing
1 4	B	Sodium Hydroxide (Denaturant , pH adjusting agent, pH adjusting agent)
-	-	Distilled Water

glenmark Klenzit-C Adapalene Clindamycin Phosphate gel

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