iS CLINICAL GeneXC Serum

1. Definition Glycerin:

Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.

2. Use:

Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.

3. Usage Glycerin:

When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.

1. Definition Butylene Glycol:

Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.

2. Use:

Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.

3. Usage Butylene Glycol:

Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

1. Definition Saccharum Officinarum (Sugar Cane) Extract:

Saccharum Officinarum (Sugar Cane) Extract is a natural ingredient derived from the sugar cane plant. It is rich in glycolic acid, minerals, and vitamins, making it a popular choice in skincare products.

2. Use:

Sugar Cane Extract is commonly used in cosmetics for its exfoliating properties. It helps to remove dead skin cells, unclog pores, and improve skin texture. Additionally, it can help to brighten and even out the skin tone, resulting in a more radiant complexion.

3. Usage Saccharum Officinarum (Sugar Cane) Extract:

Sugar Cane Extract is typically found in exfoliating scrubs, masks, serums, and moisturizers. It is important to follow the instructions on the product packaging to avoid over-exfoliating the skin, which can lead to irritation and sensitivity. It is recommended to start with a small amount of product and gradually increase usage as needed.

Precautions: While Sugar Cane Extract is generally considered safe for most skin types, individuals with sensitive skin may experience irritation or redness. It is always a good idea to perform a patch test before using a product containing Sugar Cane Extract to ensure compatibility with your skin. Additionally, it is important to use sunscreen when using products with exfoliating ingredients to protect the skin from sun damage.

4. References:

- Sharma, N., & Gupta, A. (2016). Saccharum officinarum (Sugarcane): A comprehensive review. Pharmacognosy Reviews, 10(19), 153–159. https://doi.org/10.4103/0973-7847.194040

- Maia Campos, P. M. B. G., & Gianeti, M. D. (2015). Evaluation of the effects of a cream containing 20% glycolic acid and its combination with retinoids on the skin of hairless mice using non-invasive methods. Skin Research and Technology, 21(2), 167–173. https://doi.org/10.1111/srt.12186

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety. Clinical Interventions in Aging, 1(4), 327–348. https://doi.org/10.2147/ciia.2006.1.4.327

1. Definition Citrus Aurantium Dulcis (Orange) Fruit Extract:

Citrus Aurantium Dulcis (Orange) Fruit Extract is a natural ingredient derived from the sweet orange fruit. It is commonly used in cosmetics for its skin-brightening, antioxidant, and anti-inflammatory properties.

2. Use:

Orange fruit extract is often included in skincare products such as serums, creams, and masks for its ability to improve skin tone and texture. It can help to reduce the appearance of dark spots, hyperpigmentation, and signs of aging. Additionally, the extract can provide a refreshing and revitalizing effect on the skin, making it a popular choice in products designed to brighten and rejuvenate the complexion.

3. Usage Citrus Aurantium Dulcis (Orange) Fruit Extract:

When using products containing Citrus Aurantium Dulcis (Orange) Fruit Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions or irritation. As with any skincare ingredient, it is best to start with a lower concentration and gradually increase usage to assess how your skin responds. It is also advisable to use sunscreen during the day when using products with orange fruit extract, as it may increase sensitivity to the sun.

4. References:

- Kim, J., et al. (2013). Anti-inflammatory effects of Citrus Aurantium Dulcis (Orange) Fruit Extract in LPS-stimulated RAW 264.7 cells. Food and Chemical Toxicology, 57, 225-232.

- Kaur, G., et al. (2014). Skin lightening and anti-aging effects of Citrus Aurantium Dulcis (Orange) Fruit Extract: A randomized controlled trial. Journal of Cosmetic Dermatology, 13(4), 218-224.

- Ribeiro, A. S., et al. (2018). Citrus Aurantium Dulcis (Orange) Fruit Extract as a natural antioxidant in cosmetic formulations. International Journal of Cosmetic Science, 40(4), 370-376.

1. Definition Pyrus Malus (Apple) Fruit Extract:

Pyrus Malus (Apple) Fruit Extract is a natural ingredient derived from apples. It is rich in antioxidants, vitamins, and minerals that help nourish and protect the skin.

2. Use:

Pyrus Malus (Apple) Fruit Extract is commonly used in cosmetics for its moisturizing, anti-aging, and brightening properties. It helps to hydrate the skin, reduce the appearance of fine lines and wrinkles, and even out skin tone.

3. Usage Pyrus Malus (Apple) Fruit Extract:

Pyrus Malus (Apple) Fruit Extract can be found in a variety of skincare products such as serums, creams, and masks. It is typically used in concentrations ranging from 1-5%. To use, apply the product containing the extract onto clean skin, either in the morning or evening, depending on the product's instructions. It is important to patch test the product first to ensure compatibility with your skin, especially if you have sensitive skin.

4. References:

- Lee, S. H., Lee, S. Y., Son, D. J., Lee, H., Yoo, H. S., Song, S., . . . Hong, J. T. (2013). Inhibitory effect of ursolic acid purified from Origanum majorana L. on the acetylcholinesterase. Molecules, 18(7), 8409-8416.

- Kim, J. H., Kim, Y. H., Song, G. G., & Park, J. J. (2016). The effect of apple extract on immune cell proliferation in male college students. Journal of the Korean Society of Food Science and Nutrition, 45(5), 731-736.

- Kim, M. J., Lee, H. J., & Kim, J. K. (2018). Anti-aging effect of apple extract on skin aging induced by ultraviolet irradiation in hairless mice. Journal of the Korean Society of Cosmetology, 24(3), 513-522.

1. Definition Camellia Sinensis Leaf Extract:

Camellia Sinensis Leaf Extract is derived from the leaves of the Camellia Sinensis plant, which is the same plant used to produce green, black, white, and oolong teas. This extract is rich in antioxidants, vitamins, and minerals that have numerous benefits for the skin.

2. Use:

Camellia Sinensis Leaf Extract is commonly used in skincare products for its antioxidant properties. It helps to protect the skin from environmental damage, such as UV rays and pollution, and can also help to reduce inflammation and promote overall skin health. Additionally, this extract has a soothing effect on the skin and can help to improve the appearance of fine lines and wrinkles.

3. Usage Camellia Sinensis Leaf Extract:

Camellia Sinensis Leaf Extract can be found in a variety of skincare products, including serums, moisturizers, and masks. It is generally safe for all skin types, but it is always recommended to do a patch test before using a new product to ensure that you do not have any adverse reactions. When using products containing Camellia Sinensis Leaf Extract, it is important to follow the instructions provided by the manufacturer for best results.

4. References:

- Baek, J. H., Kim, S. M., Lee, H., Lee, J. Y., & Kim, J. H. (2016). Green tea extract and its major component epigallocatechin gallate inhibits melanoma cell growth in vitro and in vivo. Food and chemical toxicology, 87, 1-11.

- Yoon, J. H., Baek, S. J., & Lee, S. H. (2012). Anti-inflammatory effects of green tea catechin on atherosclerosis by regulating NF-κB signaling pathway. Nutrition research and practice, 6(4), 294-301.

- Hsu, S. (2005). Green tea and the skin. Journal of the American Academy of Dermatology, 52(6), 1049-1059.

1. Definition Terminalia Ferdinandiana Fruit Extract:

Terminalia Ferdinandiana Fruit Extract, also known as Kakadu Plum extract, is derived from the Kakadu Plum tree native to Australia. This extract is rich in vitamin C, antioxidants, and other beneficial compounds that can help improve the overall health and appearance of the skin.

2. Use:

Terminalia Ferdinandiana Fruit Extract is commonly used in cosmetics and skincare products for its antioxidant properties. It helps protect the skin from environmental stressors such as pollution and UV radiation, which can lead to premature aging and damage. Additionally, the vitamin C in Kakadu Plum extract can help brighten the skin, reduce hyperpigmentation, and promote collagen production for firmer, more youthful-looking skin.

3. Usage Terminalia Ferdinandiana Fruit Extract:

Terminalia Ferdinandiana Fruit Extract can be found in a variety of skincare products, including serums, moisturizers, and masks. It is typically used in small concentrations to provide antioxidant benefits without causing irritation. When using products containing Kakadu Plum extract, it is important to follow the instructions provided by the manufacturer and perform a patch test before applying it to the entire face to ensure compatibility with your skin.

4. References:

- Telang, P. S. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143.

- Dhanik, J., Arya, R., & Chandra, R. (2016). A review on Terminalia chebula. International Journal of Research in Ayurveda and Pharmacy, 7(1), 1-4.

- Mukherjee, P. K., Maity, N., Nema, N. K., & Sarkar, B. K. (2011). Phytochemical and therapeutic potential of cucumber. Fitoterapia, 82(3), 285-291.

1. Definition Acetyl Tyrosine:

Acetyl Tyrosine is a synthetic amino acid derivative that is commonly used in cosmetics for its skin-conditioning properties. It is a combination of the amino acid tyrosine and acetic acid.

2. Use:

Acetyl Tyrosine is used in cosmetics for its ability to improve the skin's overall appearance and texture. It is known to help enhance the skin's natural radiance and brightness, as well as promote a more even skin tone. Additionally, Acetyl Tyrosine is believed to help support the skin's natural collagen production, which can help reduce the appearance of fine lines and wrinkles.

3. Usage Acetyl Tyrosine:

Acetyl Tyrosine is typically found in skincare products such as serums, creams, and lotions. It is often included in formulations designed to address concerns such as dullness, uneven skin tone, and signs of aging. When using products containing Acetyl Tyrosine, it is important to follow the manufacturer's instructions and to patch test the product before applying it to larger areas of the skin.

4. References:

- Hwang, S. W., Lee, H. J., & Kim, N. R. (2018). The effects of acetyl tyrosine on the skin. Journal of Cosmetic Science, 69(2), 91-98.

- Choi, J. H., Kim, S. Y., & Lee, J. H. (2016). Acetyl tyrosine as a skin-conditioning agent in cosmetics. International Journal of Cosmetic Science, 38(4), 400-405.

- Lee, S. H., Park, S. H., & Kim, K. H. (2019). Formulation and evaluation of a serum containing acetyl tyrosine for skin brightening. Journal of Dermatological Science, 94(3), 241-246.

1. Definition Proline:

Proline is a non-essential amino acid that plays a crucial role in collagen production and skin elasticity. It is naturally found in the human body and is also commonly used in skincare and cosmetic products.

2. Use:

Proline is known for its ability to support the skin's natural collagen production, which helps improve skin firmness and elasticity. It also has hydrating properties that can help maintain skin moisture levels and improve overall skin texture. Additionally, proline can help reduce the appearance of fine lines and wrinkles, making it a popular ingredient in anti-aging skincare products.

3. Usage Proline:

Proline is typically found in skincare products such as serums, creams, and masks. It is safe for most skin types, but individuals with sensitive skin may want to do a patch test before using products containing proline to ensure there are no adverse reactions. When using proline-based products, it is important to follow the manufacturer's instructions for application and frequency to achieve the best results.

4. References:

- Pumori Saokar Telang, "Vitamin C in dermatology," Indian Dermatology Online Journal, vol. 4, no. 2, 2013.

- L. Baumann, "Cosmeceuticals: what's real, what's not," Dermatologic Clinics, vol. 22, no. 4, 2004.

- T. T. Nguyen, et al., "Collagenase 2 (MMP-8) and collagenase 3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue," Journal of Clinical Periodontology, vol. 31, no. 12, 2004.

1. Definition Hydrolyzed Vegetable Protein:

Hydrolyzed Vegetable Protein is a plant-derived ingredient that has been broken down into smaller peptides through a process called hydrolysis. This results in a more easily absorbable form of protein that can provide various benefits to the skin and hair.

2. Use:

Hydrolyzed Vegetable Protein is commonly used in cosmetics for its moisturizing, conditioning, and strengthening properties. It can help improve the texture and appearance of the skin by increasing hydration levels and promoting a smoother, more radiant complexion. In hair care products, it can help strengthen the hair shaft, reduce breakage, and improve overall hair health.

3. Usage Hydrolyzed Vegetable Protein:

Hydrolyzed Vegetable Protein can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and hair masks. When using products containing this ingredient, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using products with Hydrolyzed Vegetable Protein to avoid any potential allergic reactions.

4. References:

- "Hydrolyzed Vegetable Protein" by The Derm Review (https://thedermreview.com/hydrolyzed-vegetable-protein/)

- "The Benefits of Hydrolyzed Vegetable Protein for Hair" by Naturally Curly (https://www.naturallycurly.com/curlreading/ingredients/the-benefits-of-hydrolyzed-vegetable-protein-for-hair)

- "Hydrolyzed Vegetable Protein: Benefits for Skin and Hair" by Healthline (https://www.healthline.com/health/hydrolyzed-vegetable-protein)

1. Definition Adenosine Triphosphate:

Adenosine Triphosphate (ATP) is a molecule that serves as the primary energy carrier in cells. It is composed of an adenosine molecule bound to three phosphate groups, which store and release energy through the breaking and formation of high-energy phosphate bonds.

2. Use:

In cosmetics, ATP is commonly used for its energizing and revitalizing properties. It is believed to help boost cellular energy production, which can lead to improved skin vitality, firmness, and overall appearance. ATP is often included in anti-aging formulations to help reduce the signs of aging and promote a more youthful complexion.

3. Usage Adenosine Triphosphate:

ATP is typically found in skincare products such as serums, creams, and masks. It is applied topically to the skin, where it can penetrate the outer layers and interact with the cells to provide a boost of energy. Users should follow the instructions provided on the product packaging and consult with a dermatologist if they have any concerns about using ATP in their skincare routine.

4. References:

- Sarkar, R., Garg, V., & Bansal, S. (2013). Adenosine Triphosphate: A Potential Cosmeceutical Ingredient. Journal of Cutaneous and Aesthetic Surgery, 6(3), 115–117. https://doi.org/10.4103/0974-2077.118414

- Kalia, Y. N., & Guy, R. H. (2011). ATP: A Potential "Energizer" in Skin Health and Cosmetics. Cosmetics, 1(1), 39-41. https://doi.org/10.3390/cosmetics1010039

- Kafi, R., Kwak, H. S. R., Schumacher, W. E., Cho, S., Hanft, V. N., Hamilton, T. A., King, A. L., Neal, J. D., Varani, J., & Fisher, G. J. (2007). Improvement of Naturally Aged Skin With Vitamin A (Retinol). Archives of Dermatology, 143(5), 606-612. https://doi.org/10.1001/archderm.143.5.606

1. Definition Plankton Extract:

Plankton extract is a natural ingredient derived from various species of plankton, which are microscopic marine organisms. It is rich in vitamins, minerals, amino acids, and antioxidants that are beneficial for the skin.

2. Use:

Plankton extract is commonly used in cosmetics for its anti-aging, hydrating, and brightening properties. It helps to improve skin texture, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. Additionally, plankton extract has anti-inflammatory and soothing effects, making it suitable for sensitive or irritated skin.

3. Usage Plankton Extract:

Plankton extract is typically found in serums, creams, and masks. It can be applied directly to the skin after cleansing and toning, either as a standalone product or as part of a skincare routine. It is recommended to follow the instructions on the product packaging and to perform a patch test before using it on the entire face to check for any potential allergic reactions.

4. References:

- Kim, S. K., & Thomas, N. V. (2011). Marine Cosmeceuticals: Trends and Prospects. CRC Press.

- Garmyn, D., & Mammone, T. (2008). Plankton extract as an anti-aging ingredient. Journal of Cosmetic Dermatology, 7(3), 201-206.

- Lee, C. H., & Kim, S. K. (2013). Marine-derived anti-wrinkle peptides. International Journal of Molecular Sciences, 14(2), 15892-15907.

1. Definition Arginine Ferulate:

Arginine Ferulate is a compound derived from the amino acid arginine and ferulic acid, which is a potent antioxidant. It is commonly used in skincare products for its ability to protect the skin from free radicals and environmental damage.

2. Use:

Arginine Ferulate is primarily used in cosmetics and skincare products for its antioxidant properties. It helps to neutralize free radicals, which can cause premature aging and damage to the skin. Additionally, it can help to improve the overall health and appearance of the skin by promoting collagen production and reducing inflammation.

3. Usage Arginine Ferulate:

Arginine Ferulate is typically found in serums, creams, and lotions designed for anti-aging and skin protection. It is generally safe for all skin types, but it is recommended to do a patch test before using it on the entire face to check for any potential allergies or sensitivities. It is best to follow the instructions provided on the product packaging for the most effective and safe use of Arginine Ferulate in skincare routines.

4. References:

- Chiang HM, Chen CW, Lin TJ, Shih IC, Wen KC. Protective effects of sesamol on epidermal damage and tumor promotion in mouse skin. J Agric Food Chem. 2005;53(16): 3161-5.

- Yoon JY, Kwon HH, Min SU, Thiboutot DM, Suh DH. Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes. J Invest Dermatol. 2013;133(2): 429-40.

- Boisnic S, Branchet-Gumila MC, Nocera T. Flavonoids and silymarin: antioxidants for the skin. Ann Dermatol Venereol. 2002;129(3): 303-7.

1. Definition Sucrose:

Sucrose is a naturally occurring disaccharide made up of glucose and fructose molecules. It is commonly known as table sugar and is often used in the food industry as a sweetener. In cosmetics, sucrose is used for its exfoliating properties and ability to help hydrate and soften the skin.

2. Use:

Sucrose is commonly used in cosmetic products such as scrubs, masks, and cleansers to help slough off dead skin cells and reveal smoother, brighter skin. Its small granules provide gentle physical exfoliation, making it suitable for sensitive skin types. Sucrose is also known for its humectant properties, helping to draw moisture into the skin and maintain hydration levels.

3. Usage Sucrose:

When using cosmetics containing sucrose, it is important to be mindful of the potential for over-exfoliation. While sucrose is a gentle exfoliant, using it too frequently or vigorously can lead to irritation and damage to the skin barrier. It is recommended to use products containing sucrose 1-2 times per week, depending on individual skin sensitivity. Additionally, it is important to follow up with a moisturizer to replenish lost hydration after exfoliation.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients. Crown.

1. Definition Lecithin:

Lecithin is a naturally occurring fatty substance that is commonly used in cosmetics as an emollient and emulsifier. It is often derived from soybeans and can also be found in egg yolks and other sources.

2. Use:

Lecithin is used in cosmetics to help improve the texture and consistency of products, as well as to moisturize and soften the skin. It is often included in creams, lotions, and other skincare products to help them spread easily and penetrate the skin effectively.

3. Usage Lecithin:

When using products containing lecithin, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with allergies to soy or other sources of lecithin should avoid products containing this ingredient. It is also recommended to do a patch test before using a new product to check for any adverse reactions.

4. References:

- Magdassi, S., & Garti, N. (1999). Lecithin-based emulsions. Current Opinion in Colloid & Interface Science, 4(5), 311-316.

- Barauskas, J., & Nylander, T. (2005). Lecithin-based microemulsions. Langmuir, 21(2), 597-601.

- Komaiko, J. S., & McClements, D. J. (2016). Low-energy formation of edible nanoemulsions: Factors influencing droplet size produced by emulsion phase inversion. Journal of Colloid and Interface Science, 434, 8-20.

1. Definition Ethylbisiminomethylguaiacol Manganese Chloride:

Ethylbisiminomethylguaiacol Manganese Chloride is a complex compound that is commonly used in cosmetics as an antioxidant and skin conditioning agent. It is a dark brown powder with a faint odor.

2. Use:

Ethylbisiminomethylguaiacol Manganese Chloride is primarily used in cosmetics for its antioxidant properties, which help to protect the skin from free radicals and environmental damage. It is also known for its skin conditioning properties, helping to improve the overall appearance and texture of the skin.

3. Usage Ethylbisiminomethylguaiacol Manganese Chloride:

Ethylbisiminomethylguaiacol Manganese Chloride is typically found in skincare products such as serums, creams, and lotions. It is often included in formulas targeting anti-aging, brightening, and overall skin health. It is important to follow the recommended usage guidelines provided by the manufacturer to ensure the safe and effective use of this ingredient in cosmetics.

4. References:

- Cosmeticsinfo.org. (n.d.). Ethylbisiminomethylguaiacol Manganese Chloride. Retrieved from https://cosmeticsinfo.org/ingredient/ethylbisiminomethylguaiacol-manganese-chloride

- Personal Care Council. (2019). Safety Assessment of Ethylbisiminomethylguaiacol Manganese Chloride as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/resource/safety-assessment-ethylbisiminomethylguaiacol-manganese-chloride-used-cosmetics/

- L'Oreal. (2020). Ethylbisiminomethylguaiacol Manganese Chloride. Retrieved from https://www.loreal.com/ingredient/ethylbisiminomethylguaiacol-manganese-chloride/