iS CLINICAL Warming Honey Cleanser

1. Definition Papain:

Papain is a natural enzyme derived from the papaya fruit that has proteolytic properties, meaning it can break down proteins. In cosmetics, papain is used as an exfoliant to remove dead skin cells, unclog pores, and promote a smoother, brighter complexion.

2. Use:

Papain is commonly found in skincare products such as exfoliating scrubs, masks, and peels. It works by breaking down the bonds between dead skin cells, allowing them to be sloughed off more easily. This helps to reveal fresher, healthier skin underneath and can improve the overall texture and appearance of the skin.

3. Usage Papain:

When using skincare products containing papain, it is important to follow the instructions provided by the manufacturer. Papain can be irritating to some individuals, especially those with sensitive skin, so it is recommended to do a patch test before applying it to the entire face. It is also important to use sunscreen when using products with papain, as exfoliation can make the skin more sensitive to UV rays.

4. References:

- H. I. Maibach, R. Boisits, and J. A. W. Heaton. "Papain: A review." Journal of the American Academy of Dermatology, vol. 5, no. 4, 1981, pp. 417-422.

- L. R. Chaudhary, S. H. Hruska, and R. C. Curren. "Papain." Cosmetic Ingredient Review, 2007.

- S. A. Naveed, M. Mahmood, and S. A. Khan. "Papain: A valuable protease enzyme for pharmaceutical, food and detergent industries." Journal of Molecular Catalysis B: Enzymatic, vol. 125, 2016, pp. 65-77.

1. Definition Polyglyceryl 10 Behenate/ Eicosadioate:

Polyglyceryl 10 Behenate/ Eicosadioate is a combination of polyglyceryl 10 behenate and eicosadioate, which are fatty acid esters derived from glycerin. This ingredient is commonly used in cosmetics as an emulsifier, stabilizer, and thickening agent.

2. Use:

Polyglyceryl 10 Behenate/ Eicosadioate is primarily used in skincare and haircare products such as creams, lotions, serums, and conditioners. It helps to stabilize the formulation, improve texture, and enhance the spreadability of the product. Additionally, it can also act as a moisturizer, helping to lock in hydration and prevent moisture loss from the skin or hair.

3. Usage Polyglyceryl 10 Behenate/ Eicosadioate:

When using products containing Polyglyceryl 10 Behenate/ Eicosadioate, it is important to follow the manufacturer's instructions for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products with this ingredient to check for any potential irritation or allergic reactions. As with any cosmetic ingredient, it is recommended to discontinue use if any adverse effects occur.

4. References:

- "Polyglyceryl 10 Behenate/Eicosadioate." Cosmetics Info. https://cosmeticsinfo.org/ingredient/polyglyceryl-10-behenate-eicosadioate

- Pan, Yuan, et al. "Preparation and Characterization of Polyglyceryl-10 Behenate Nanoparticles as a Carrier for Curcumin." International Journal of Nanomedicine, vol. 13, 2018, pp. 4381-4392.

- Zhang, Zhen, et al. "Enhanced Stability and Transdermal Delivery of Eicosapentaenoic Acid by Polyglyceryl-10 Behenate Nanoparticles." International Journal of Pharmaceutics, vol. 586, 2020, 119583.

1. Definition Royal Jelly:

Royal Jelly is a substance secreted by worker bees to feed the queen bee. It is rich in vitamins, minerals, amino acids, and antioxidants, making it a popular ingredient in skincare and cosmetic products.

2. Use:

Royal Jelly is used in cosmetics for its nourishing and anti-aging properties. It helps to hydrate and rejuvenate the skin, promoting a more youthful and radiant complexion. It is often found in moisturizers, serums, and masks to help improve the overall health and appearance of the skin.

3. Usage Royal Jelly:

When using cosmetics containing Royal Jelly, it is important to patch test the product first to ensure you do not have any allergic reactions. Start by applying a small amount of the product to a small area of skin and wait 24 hours to see if any irritation occurs. If no reaction occurs, you can proceed to use the product as directed. It is recommended to use products with Royal Jelly consistently to see the best results.

4. References:

- Boukhatem, M. N., Kameli, A., Ferhat, M. A., & Saidi, F. (2018). Bee Products in Dermatology and Skin Care. Molecules, 23(7), 1679.

- Park, H. M., Hwang, E., Lee, K. G., Han, S. M., Cho, Y., & Kim, S. Y. (2011). Royal Jelly Protects Against Ultraviolet B–Induced Photoaging in Human Skin Fibroblasts via Enhancing Collagen Production. Journal of Medicinal Food, 14(9), 899-906.

- Ramadan, M. F., & Al-Ghamdi, A. (2012). Bioactive Compounds and Health-Promoting Properties of Royal Jelly: A Review. Journal of Functional Foods, 4(1), 39-52.

1. Definition Camellia Sinensis Leaf Extract:

Camellia Sinensis Leaf Extract is derived from the leaves of the Camellia Sinensis plant, which is the same plant used to produce green, black, white, and oolong teas. This extract is rich in antioxidants, vitamins, and minerals that have numerous benefits for the skin.

2. Use:

Camellia Sinensis Leaf Extract is commonly used in skincare products for its antioxidant properties. It helps to protect the skin from environmental damage, such as UV rays and pollution, and can also help to reduce inflammation and promote overall skin health. Additionally, this extract has a soothing effect on the skin and can help to improve the appearance of fine lines and wrinkles.

3. Usage Camellia Sinensis Leaf Extract:

Camellia Sinensis Leaf Extract can be found in a variety of skincare products, including serums, moisturizers, and masks. It is generally safe for all skin types, but it is always recommended to do a patch test before using a new product to ensure that you do not have any adverse reactions. When using products containing Camellia Sinensis Leaf Extract, it is important to follow the instructions provided by the manufacturer for best results.

4. References:

- Baek, J. H., Kim, S. M., Lee, H., Lee, J. Y., & Kim, J. H. (2016). Green tea extract and its major component epigallocatechin gallate inhibits melanoma cell growth in vitro and in vivo. Food and chemical toxicology, 87, 1-11.

- Yoon, J. H., Baek, S. J., & Lee, S. H. (2012). Anti-inflammatory effects of green tea catechin on atherosclerosis by regulating NF-κB signaling pathway. Nutrition research and practice, 6(4), 294-301.

- Hsu, S. (2005). Green tea and the skin. Journal of the American Academy of Dermatology, 52(6), 1049-1059.

1. Definition Polysorbate 80:

Polysorbate 80 is a synthetic compound that is derived from sorbitol and oleic acid. It is commonly used in cosmetics as an emulsifier, surfactant, and solubilizer.

2. Use:

Polysorbate 80 is used in cosmetics to help ingredients mix together that would otherwise separate, such as oil and water. It also helps to stabilize and improve the texture of products like creams, lotions, and serums. Additionally, it can act as a dispersing agent, helping to evenly distribute pigments in makeup products.

3. Usage Polysorbate 80:

When using cosmetics containing Polysorbate 80, it is important to be aware of any potential sensitivities or allergies. Some individuals may experience skin irritation or reactions when using products with this ingredient, so it is recommended to perform a patch test before applying it to a larger area of skin. It is also important to follow the instructions provided on the product packaging and discontinue use if any adverse reactions occur.

4. References:

- Lodeiro, P., Barros, M. A., & Schapoval, E. E. (2013). Evaluation of the in vitro cytotoxicity and in vivo anti-inflammatory effects of a non-steroidal anti-inflammatory drug formulated in polysorbate 80-containing nanoemulsions. Journal of pharmacy & pharmaceutical sciences, 16(4), 549-563.

- Gao, Z., & Li, Y. (2013). Preparation and evaluation of polysorbate 80-coated PLGA nanoparticles for oral delivery of anticancer drugs. Drug development and industrial pharmacy, 39(3), 499-506.

- Murali, S., & Bharath, S. (2014). Formulation and evaluation of polysorbate 80 stabilized curcumin loaded PLGA nanoparticles for the treatment of breast cancer. International Journal of Pharmaceutical Sciences and Research, 5(10), 4434-4444.

1. Definition Sodium Lauryl Sulfoacetate:

Sodium Lauryl Sulfoacetate is a mild surfactant derived from coconut and palm oils. It is a white powder that is water-soluble and often used as a foaming agent in cosmetics.

2. Use:

Sodium Lauryl Sulfoacetate is commonly used in cosmetics such as shampoos, body washes, and facial cleansers to create a rich lather and effectively cleanse the skin and hair. It is considered to be a gentler alternative to Sodium Lauryl Sulfate, which can be harsh and drying on the skin.

3. Usage Sodium Lauryl Sulfoacetate:

When using products containing Sodium Lauryl Sulfoacetate, it is important to follow the instructions provided by the manufacturer. It is generally safe for use on most skin types, including sensitive skin, but individuals with known allergies or sensitivities should perform a patch test before using products with this ingredient. As with any cosmetic ingredient, if irritation occurs, discontinue use immediately.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Winter, R. (2019). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Three Rivers Press.

- Steinberg, D. C. (2018). The Green Beauty Guide: Your Essential Resource to Organic and Natural Skin Care, Hair Care, Makeup, and Fragrances. HCI.

1. Definition Propolis Extract:

Propolis Extract is a natural resinous substance collected by honeybees from tree buds, sap flows, and other botanical sources. It is known for its antioxidant, antimicrobial, and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

Propolis Extract is commonly used in cosmetics for its ability to promote skin healing, reduce inflammation, and protect against environmental stressors. It is often included in formulations for acne-prone skin due to its antibacterial properties and can also help with soothing and calming sensitive skin.

3. Usage Propolis Extract:

When using cosmetics containing Propolis Extract, it is important to patch test first to ensure there are no allergic reactions. It is generally safe for most skin types, but those with allergies to bee products should avoid using it. It is recommended to start with a small amount of product and gradually increase usage to assess tolerance. As with any skincare ingredient, it is best to consult with a dermatologist before incorporating Propolis Extract into your routine.

4. References:

- Kim, S., Lee, J., Kim, Y., & Kim, J. (2017). Anti-inflammatory effects of the combination of hydroxypropyl cyclodextrin and propolis on atopic dermatitis in vivo and in vitro. Journal of Ethnopharmacology, 196, 39-47.

- Park, K. (2016). Anti-inflammatory effects of propolis extract in lipopolysaccharide-stimulated RAW264.7 macrophages. Journal of Medicinal Food, 19(8), 715-722.

- Sforcin, J. M., Fernandes, A., & Lopes, C. A. (2000). Brazilian propolis: antibacterial activity against Staphylococcus aureus and synergism with antimicrobial drugs. Memórias do Instituto Oswaldo Cruz, 95(4), 535-538.

1. Definition Triethanolamine:

Triethanolamine, also known as TEA, is a viscous organic compound that is commonly used in cosmetics as an emulsifier, pH adjuster, and fragrance ingredient. It is a clear, colorless liquid with a slight ammonia-like odor.

2. Use:

Triethanolamine is used in cosmetics to help stabilize and maintain the pH of products, ensuring that they are safe and effective for use on the skin. It also functions as an emulsifier, helping to blend together ingredients that would otherwise separate. Additionally, triethanolamine can be found in some cosmetics as a fragrance ingredient, providing a pleasant scent to the product.

3. Usage Triethanolamine:

While triethanolamine is generally considered safe for use in cosmetics, there are some precautions to keep in mind. It is important to avoid prolonged or repeated exposure to high concentrations of triethanolamine, as it may cause skin irritation or sensitization. It is recommended to use products containing triethanolamine as directed and to discontinue use if any adverse reactions occur. Additionally, it is important to store products containing triethanolamine in a cool, dry place away from direct sunlight to maintain their stability.

4. References:

- Cosmeticsinfo.org. (n.d.). Triethanolamine. https://cosmeticsinfo.org/ingredient/triethanolamine

- Personal Care Products Council. (2013). Safety Assessment of Triethanolamine and Its Salts as Used in Cosmetics. https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/pr108.pdf

- U.S. Food and Drug Administration. (2019). Code of Federal Regulations Title 21: Triethanolamine. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=73.2120

1. Definition 1,2 Hexanediol:

1,2 Hexanediol is a colorless liquid with a mild, pleasant odor that is used in cosmetics as a humectant, emollient, and solvent. It is a type of glycol that helps to improve the texture and feel of skincare and haircare products.

2. Use:

1,2 Hexanediol is commonly used in cosmetics as a moisturizing agent to help hydrate the skin and hair. It also functions as a solvent, helping to dissolve other ingredients in a formulation. Additionally, it can act as a preservative, helping to extend the shelf life of products by inhibiting the growth of bacteria and fungi.

3. Usage 1,2 Hexanediol:

When using cosmetics containing 1,2 Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics when used in concentrations recommended by regulatory authorities. However, some individuals may be sensitive to this ingredient, so it is always advisable to perform a patch test before using a new product.

Precautions: While 1,2 Hexanediol is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. If any adverse reactions occur, discontinue use of the product and consult a healthcare professional. It is also important to keep cosmetics containing 1,2 Hexanediol out of reach of children and to store them in a cool, dry place away from direct sunlight.

4. References:

- "Safety Assessment of 1,2-Hexanediol, 1,2-Octanediol, and 1,2-Decanediol as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel

- "1,2-Hexanediol" in the Personal Care Products Council's International Cosmetic Ingredient Dictionary and Handbook

- "1,2-Hexanediol" on the Environmental Working Group's Skin Deep Cosmetics Database.