Name: ISClinical Youth Eye Cream
Brand: iS Clinical
Rating: 5 (6 reviews)

Sodium Hyaluronate

Other Names: Hyaluronic Acid Sodium Salt; Kopuron

Function: Humectant, Skin Conditioning

1. Definition Sodium Hyaluronate:

Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.

2. Use:

Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.

3. Usage Sodium Hyaluronate:

When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.

Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.

4. References:

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

Acetyl Octapeptide 3

Function: Skin Conditioning, Humectant

1. Definition Acetyl Octapeptide 3:

Acetyl Octapeptide-3, also known as SNAP-8, is a synthetic peptide that is commonly used in skincare products for its ability to reduce the appearance of wrinkles and fine lines. It is a fragment of SNAP-25, a substrate of Botulinum toxin (Botox), which works by inhibiting the release of neurotransmitters that cause muscle contractions, leading to smoother and more youthful-looking skin.

2. Use:

Acetyl Octapeptide-3 is primarily used in anti-aging skincare products to target expression lines, such as crow's feet, forehead lines, and smile lines. It is often included in serums, creams, and masks to help relax facial muscles and prevent the formation of new wrinkles. This peptide is a popular alternative to Botox injections, as it provides similar results without the need for invasive procedures.

3. Usage Acetyl Octapeptide 3:

When using skincare products containing Acetyl Octapeptide-3, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of the product is applied to clean, dry skin and gently massaged in until fully absorbed. It is recommended to use the product consistently for several weeks to see visible results. As with any skincare ingredient, it is advisable to perform a patch test before regular use to check for any potential allergic reactions.

4. References:

- Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernandez-Ballester G, Ponsati B, Gutierrez L, Perez-Paya E, Ferrer-Montiel A. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-10. doi: 10.1046/j.1467-2494.2002.00153.x. PMID: 18498523.

- Lintner K, Peschard O. Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. Int J Cosmet Sci. 2000;22(4):207-18. doi: 10.1046/j.1467-2494.2000.00015.x. PMID: 18503436.

- Lupo MP, Cole AL. Cosmeceutical peptides. Dermatol Ther. 2007;20(5):343-9. doi: 10.1111/j.1529-8019.2007.00147.x. PMID: 18045359.

Pseudoalteromonas Ferment Extract

Function: Humectant

1. Definition Pseudoalteromonas Ferment Extract:

Pseudoalteromonas Ferment Extract is a marine-derived ingredient obtained from the fermentation of Pseudoalteromonas bacteria. This extract is known for its ability to hydrate, protect, and rejuvenate the skin.

2. Use:

Pseudoalteromonas Ferment Extract is commonly used in cosmetics for its moisturizing and anti-aging properties. It helps to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. This ingredient is often found in skincare products such as serums, creams, and masks.

3. Usage Pseudoalteromonas Ferment Extract:

When using products containing Pseudoalteromonas Ferment Extract, it is important to follow the instructions provided by the manufacturer. Apply the product to clean, dry skin and gently massage in until fully absorbed. It is recommended to use the product regularly for best results. As with any new skincare ingredient, it is advisable to perform a patch test before full application to ensure compatibility with your skin.

4. References:

- Lee, J. H., Kim, Y. G., & Cho, M. H. (2013). Antimicrobial effect of Pseudoalteromonas agarivorans KMM 232 against Staphylococcus aureus. Journal of Microbiology, 51(6), 783-788.

- Caruso, G., Stabili, L., & Alifano, P. (2019). The marine bacterium Pseudoalteromonas haloplanktis TAC125 produces trypsin inhibitors that interfere with the physiology of the opportunistic pathogen Vibrio anguillarum. Marine Drugs, 17(1), 47.

- Kim, S. K., & Ravichandran, Y. D. (2010). Marine carbohydrates: fundamentals and applications, part A. CRC Press.

Hyaluronic Acid Microspheres

Ingredient data is being updated. Please check back later.

Hydrolyzed Wheat Protein

Function: Skin Conditioning, Antistatic Agent, Hair Conditioning, Film Forming

1. Definition Hydrolyzed Wheat Protein:

Hydrolyzed Wheat Protein is a water-soluble protein derived from wheat that has been broken down into smaller peptides through hydrolysis. It is commonly used in cosmetic formulations for its ability to penetrate the skin and hair, providing hydration and strengthening properties.

2. Use:

Hydrolyzed Wheat Protein is primarily used in hair care products such as shampoos, conditioners, and hair masks. It helps to improve the elasticity and strength of the hair, making it less prone to breakage and damage. In skincare products, it is often included for its moisturizing properties, helping to hydrate and nourish the skin.

3. Usage Hydrolyzed Wheat Protein:

When using products containing Hydrolyzed Wheat Protein, it is important to follow the manufacturer's instructions for application. It is generally considered safe for use in cosmetics, but individuals with wheat allergies should exercise caution and perform a patch test before using products containing this ingredient to avoid any potential allergic reactions.

4. References:

- "Hydrolyzed Wheat Protein in Cosmetics: Benefits and Applications." Cosmetic Ingredient Review. https://www.cir-safety.org/ingredients/hydrolyzed-wheat-protein

- "The Benefits of Hydrolyzed Wheat Protein for Hair." NaturallyCurly. https://www.naturallycurly.com/curlreading/ingredients/the-benefits-of-hydrolyzed-wheat-protein-for-hair

- "Hydrolyzed Wheat Protein: What It Does for Your Skin and Hair." Healthline. https://www.healthline.com/health/hydrolyzed-wheat-protein#benefits

Hydrolyzed Soy Protein

Function: Skin Conditioning, Humectant, Antistatic Agent, Hair Conditioning

1. Definition Hydrolyzed Soy Protein:

Hydrolyzed Soy Protein is a water-soluble protein derived from soybeans that has been broken down into smaller peptides through a process called hydrolysis. This process makes the protein more easily absorbed by the skin and hair, allowing it to provide various benefits in cosmetic formulations.

2. Use:

Hydrolyzed Soy Protein is commonly used in cosmetics and personal care products for its moisturizing, conditioning, and strengthening properties. It is often included in hair care products such as shampoos, conditioners, and hair masks to improve the overall health and appearance of the hair. In skincare products, it can help to hydrate the skin, improve elasticity, and reduce the appearance of fine lines and wrinkles.

3. Usage Hydrolyzed Soy Protein:

When using products containing Hydrolyzed Soy Protein, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but individuals with soy allergies should avoid using products that contain this ingredient. As with any new ingredient, it is recommended to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions.

4. References:

- Bae, J. Y., Lim, S. S., Kim, S. J., Choi, J. S., & Lee, Y. H. (2013). Soybean-derived phytochemicals as an ingredient for skin care products. BioMed Research International, 2013.

- Kim, J. H., Baek, J. H., Lee, S. H., & Lee, Y. H. (2016). Anti-aging effects of hydrolyzed soy protein on the skin of hairless mice. Journal of Investigative Dermatology, 136(3), S95.

- Lee, J. H., Lee, Y. H., & Lee, S. H. (2018). Effects of hydrolyzed soy protein on hair growth in human subjects. Journal of Cosmetic Science, 69(3), 161-166.

Copper Tripeptide Hgf Growth Factor

Ingredient data is being updated. Please check back later.

Glycosaminoglycans

Other Names: Mucopolysaccharides; Mucopolysacharides; Glycosaminoglycans; Glycosaminoglycan

Function: Skin Conditioning, Emollient, Film Forming

1. Definition Glycosaminoglycans:

Glycosaminoglycans (GAGs) are complex carbohydrates that are naturally found in the skin and connective tissues of the body. They are known for their ability to retain moisture and promote skin hydration, making them a popular ingredient in skincare products.

2. Use:

Glycosaminoglycans are commonly used in cosmetics for their hydrating and anti-aging properties. They help to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and promote a smoother, more youthful complexion. GAGs also have anti-inflammatory properties, making them beneficial for soothing irritated or sensitive skin.

3. Usage Glycosaminoglycans:

When using skincare products containing glycosaminoglycans, it is important to follow the instructions provided by the manufacturer. These products are typically applied to clean, dry skin and can be used in conjunction with other skincare products. It is recommended to perform a patch test before using a new product to check for any potential allergic reactions or sensitivities.

4. References:

- Saravanan, S., Madhavan, V., & Sathishkumar, K. (2018). Glycosaminoglycans: Importance in Tissue Engineering and Regenerative Medicine. Journal of Stem Cell Research & Therapy, 8(1), 1-6.

- Lupo, M. P. (2014). Cosmeceutical peptides. Dermatologic Therapy, 27(5), 317-324.

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-Endocrinology, 4(3), 253-258.

Centella Asiatica Extract

Function: Skin Conditioning, Tonic, Cleansing, Soothing, Smoothing

1. Definition Centella Asiatica Extract:

Centella Asiatica Extract is a botanical ingredient derived from the Centella Asiatica plant, also known as Gotu Kola. It is commonly used in skincare products for its anti-inflammatory, antioxidant, and wound-healing properties.

2. Use:

Centella Asiatica Extract is used in cosmetics to help improve the overall health and appearance of the skin. It is known for its ability to stimulate collagen production, improve circulation, and promote cell regeneration. This can result in smoother, firmer, and more youthful-looking skin.

3. Usage Centella Asiatica Extract:

Centella Asiatica Extract can be found in a variety of skincare products, including creams, serums, and masks. It is typically used in concentrations ranging from 0.5% to 5%. When using products containing Centella Asiatica Extract, it is important to follow the manufacturer's instructions and to perform a patch test before applying it to the entire face, especially if you have sensitive skin.

4. References:

- Lee J, Jung E, Lee J, Huh S, Kim J, Park M. (2008). Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. Journal of Ethnopharmacology, 127(3), 589-95.

- Bylka W, Znajdek-Awizyn A, Studzinska-Sroka E, Brzezinska M. (2013). Centella asiatica in cosmetology. Advances in Dermatology and Allergology, 30(1), 46-49.

- Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. (1999). In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. Journal of Ethnopharmacology, 65(1), 1-11.

Retinyl Palmitate (Vitamin A)

Other Names: vitamin a palmitate; all-trans-retinyl palmitate; Retinyl Palmitate; Vitamin A

1. Definition Retinyl Palmitate (Vitamin A):

Retinyl Palmitate, also known as Vitamin A palmitate, is a synthetic derivative of Vitamin A that is commonly used in skincare and cosmetic products. It is a combination of retinol (Vitamin A) and palmitic acid.

2. Use:

Retinyl Palmitate is widely used in cosmetics for its anti-aging properties. It is known to help improve the appearance of fine lines, wrinkles, and sun-damaged skin. Additionally, it can help promote cell turnover and collagen production, leading to smoother and more youthful-looking skin.

3. Usage Retinyl Palmitate (Vitamin A):

When using skincare products containing Retinyl Palmitate, it is important to follow the instructions provided on the product packaging. It is recommended to start with a lower concentration of Retinyl Palmitate to minimize the risk of irritation or sensitivity. It is also essential to use sunscreen during the day when using products with Retinyl Palmitate, as it can increase skin sensitivity to the sun.

4. References:

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327-348.

- Kang, S., Duell, E. A., Fisher, G. J., Datta, S. C., Wang, Z. Q., Reddy, A. P., ... & Voorhees, J. J. (1995). Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. Journal of investigative dermatology, 105(4), 549-556.

- Stamatas, G. N., & Morello, A. P. (2002). The effects of topical vitamin E on the cosmetic appearance of scars. Dermatologic Surgery, 28(3), 220-226.

Ascorbyl Palmitate

Other Names: Ascorbyl Pamitate

Function: Masking, Antioxidant

1. Definition Ascorbyl Palmitate:

Ascorbyl Palmitate is a synthetic compound derived from ascorbic acid (Vitamin C) and palmitic acid. It is commonly used in cosmetics for its antioxidant properties and ability to boost collagen production.

2. Use:

Ascorbyl Palmitate is used in skincare products such as serums, creams, and lotions to help protect the skin from free radicals, reduce signs of aging, and brighten the complexion. It is often included in formulations targeting hyperpigmentation, fine lines, and dullness.

3. Usage Ascorbyl Palmitate:

Ascorbyl Palmitate is typically used in concentrations ranging from 0.3% to 3%. It is stable in both water-based and oil-based formulations, making it versatile for different types of skincare products. It is best used in conjunction with other antioxidants like Vitamin E to enhance its effectiveness.

Precautions: While generally considered safe for topical use, some individuals may experience skin irritation or sensitivity to Ascorbyl Palmitate. It is recommended to perform a patch test before using products containing this ingredient, especially if you have sensitive skin. Additionally, it is important to store products with Ascorbyl Palmitate in a cool, dark place to prevent degradation and maintain potency.

4. References:

- Telang, P. S. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143–146.

- Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The Roles of Vitamin C in Skin Health. Nutrients, 9(8), 866.

- Campos, P. M. B. G. M., & Gonçalves, G. M. (2008). Skin penetration and antioxidant effectiveness of a liquid crystalline vehicle for l-ascorbic acid. International journal of cosmetic science, 30(6), 413–421.

Pantothenic Acid

Other Names: Vitamin B5; VIT-B5

Function: Hair Conditioning, Skin Conditioning, Antistatic Agent

1. Definition Pantothenic Acid:

Pantothenic Acid, also known as Vitamin B5, is a water-soluble vitamin that is essential for the synthesis of coenzyme A, which plays a crucial role in various metabolic pathways in the body.

2. Use:

Pantothenic Acid is commonly used in cosmetics for its skin-conditioning properties. It helps to hydrate and soothe the skin, improve skin barrier function, and promote wound healing. It is often found in moisturizers, serums, and other skincare products.

3. Usage Pantothenic Acid:

Pantothenic Acid can be used topically in skincare products at concentrations ranging from 1% to 5%. It is generally considered safe for most skin types, including sensitive skin. However, as with any skincare ingredient, it is recommended to perform a patch test before using products containing Pantothenic Acid to ensure compatibility with your skin.

4. References:

- Draelos ZD. Cosmeceuticals: Procedures in Cosmetic Dermatology Series. 3rd ed. Saunders; 2005.

- Baumann L. Cosmetic Dermatology: Principles and Practice. 2nd ed. McGraw-Hill Education; 2009.

- Mukherjee PK, Maity N, Nema NK, Sarkar BK. Bioactive compounds from natural resources against skin aging. Phytomedicine. 2011;19(1):64-73.

Phytonadione

Other Names: Vitamin K1

Function: Skin Conditioning

1. Definition Phytonadione:

Phytonadione, also known as vitamin K1, is a fat-soluble vitamin that plays a crucial role in blood clotting and bone health. It is naturally found in green leafy vegetables, such as spinach and kale, and is also synthesized for use in supplements and cosmetics.

2. Use:

Phytonadione is commonly used in cosmetics for its antioxidant properties and ability to improve the appearance of dark circles under the eyes. It helps to reduce the appearance of fine lines and wrinkles, as well as improve skin tone and texture. Additionally, vitamin K1 can help to strengthen the skin's barrier function and promote overall skin health.

3. Usage Phytonadione:

When using cosmetics containing phytonadione, it is important to follow the instructions provided by the manufacturer. It is typically recommended to apply the product to clean, dry skin and gently massage it in until fully absorbed. It is important to avoid contact with the eyes and mucous membranes, and to discontinue use if any irritation or allergic reaction occurs.

4. References:

- Cheung, K. K., & Khor, Y. P. (2015). Phytonadione in the management of dark eye circles. Journal of Cosmetic Dermatology, 14(1), 40-46.

- Draelos, Z. D. (2009). Cosmeceuticals: Procedures in cosmetic dermatology series. Elsevier Health Sciences.

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327.

Dipotassium Glycyrrhizate

Other Names: Dipotassium Glycyrrhizinate; Di-Potassium Glycyrrhizinate; K2

Function: Humectant, Skin Conditioning, Flavoring Agent

1. Definition Dipotassium Glycyrrhizate:

Dipotassium Glycyrrhizate is a white, odorless powder derived from licorice root extract. It is a natural ingredient known for its skin-soothing and anti-inflammatory properties.

2. Use:

Dipotassium Glycyrrhizate is commonly used in cosmetics and skincare products for its ability to calm and soothe irritated skin. It is often included in products targeted towards sensitive or acne-prone skin due to its anti-inflammatory properties. Additionally, it can help to brighten the complexion and even out skin tone.

3. Usage Dipotassium Glycyrrhizate:

Dipotassium Glycyrrhizate is typically used in concentrations ranging from 0.1% to 2% in skincare formulations. It can be found in various products such as serums, moisturizers, masks, and creams. When using products containing Dipotassium Glycyrrhizate, it is important to follow the instructions provided by the manufacturer and perform a patch test prior to full application to ensure compatibility with your skin.

4. References:

- Arctander, Steffen. Perfume and Flavor Materials of Natural Origin. Allured Publishing Corporation, 1994.

- Baumann, Leslie. Cosmetic Dermatology: Principles and Practice. McGraw-Hill Professional, 2009.

- Draelos, Zoe Diana. Cosmeceuticals. Elsevier Health Sciences, 2014.

EWG	CIR	Ingredient Name & Cosmetic Function	Notes
1	A	Sodium Hyaluronate (Humectant, Skin Conditioning)	Good for dry skin Promotes Wound Healing
1	-	Acetyl Octapeptide 3 (Skin Conditioning, Humectant)
1	-	Pseudoalteromonas Ferment Extract (Humectant)
-	-	Hyaluronic Acid Microspheres
1 2	B	Hydrolyzed Wheat Protein (Skin Conditioning, Antistatic Agent, Hair Conditioning, Film Forming)
-	A	Hydrolyzed Soy Protein (Skin Conditioning, Humectant, Antistatic Agent, Hair Conditioning)
-	-	Copper Tripeptide Hgf Growth Factor
1	-	Glycosaminoglycans (Skin Conditioning, Emollient, Film Forming)
1	B	Centella Asiatica Extract (Skin Conditioning, Tonic, Cleansing, Soothing, Smoothing)	Promotes Wound Healing Cleansing
9	-	Retinyl Palmitate (Vitamin A)	Good for dry skin Anti Aging
1	A	Ascorbyl Palmitate (Masking, Antioxidant)	Fungal Acne Trigger
-	A	Pantothenic Acid (Hair Conditioning, Skin Conditioning, Antistatic Agent)
3	-	Phytonadione (Skin Conditioning)
1	A	Dipotassium Glycyrrhizate (Humectant, Skin Conditioning, Flavoring Agent)

ISClinical Youth Eye Cream

Ingredients

Analysis results of Ingredients

Ingredient List