Kmax Stimulating Hair Growth Therapy

1. Definition Polysorbate 20:

Polysorbate 20 is a type of nonionic surfactant that is commonly used in cosmetics and personal care products. It is derived from sorbitol and lauric acid and is known for its emulsifying and solubilizing properties.

2. Use:

Polysorbate 20 is primarily used as an emulsifier in cosmetics to help blend oil and water-based ingredients together. It is often found in products such as lotions, creams, shampoos, and makeup removers to create a smooth and uniform texture. Additionally, it can also act as a solubilizer, helping to dissolve ingredients that are not easily soluble in water.

3. Usage Polysorbate 20:

When using products containing polysorbate 20, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions when exposed to this ingredient. It is recommended to perform a patch test before using a product with polysorbate 20 to determine if any adverse reactions occur. Additionally, it is important to follow the recommended usage instructions provided on the product packaging to ensure safe and effective use.

4. References:

- CosmeticsInfo.org. (n.d.). Polysorbate 20. https://cosmeticsinfo.org/ingredient/polysorbate-20

- Personal Care Council. (2019). Polysorbate 20. https://www.personalcarecouncil.org/ingredient-dictionary/ingredient/2477

- National Center for Biotechnology Information. (2009). Polysorbate 20. https://pubchem.ncbi.nlm.nih.gov/compound/Polysorbate-20

1. Definition Peg 40 Hydrogenated Castor Oil:

Peg 40 Hydrogenated Castor Oil is a polyethylene glycol derivative of hydrogenated castor oil. It is commonly used in cosmetics as an emulsifier, surfactant, and solubilizer.

2. Use:

Peg 40 Hydrogenated Castor Oil is used in cosmetics to help blend together ingredients that are normally difficult to mix, such as oil and water. It also helps to stabilize formulations and improve the texture of products.

3. Usage Peg 40 Hydrogenated Castor Oil:

Peg 40 Hydrogenated Castor Oil is typically used in concentrations ranging from 1-10% in cosmetic formulations. It is often found in creams, lotions, serums, and other skincare products. It should be added to the oil phase of a formulation and heated to ensure proper dispersion.

Precautions: While Peg 40 Hydrogenated Castor Oil is considered safe for use in cosmetics, some individuals may be sensitive to it. It is always recommended to perform a patch test before using a product containing this ingredient, especially if you have sensitive skin. Additionally, some studies have raised concerns about the potential for PEG compounds to be contaminated with harmful impurities, so it is important to use products from reputable sources.

4. References:

- "PEG-40 Hydrogenated Castor Oil." Cosmetics Info, www.cosmeticsinfo.org/ingredient/peg-40-hydrogenated-castor-oil.

- "PEG-40 Hydrogenated Castor Oil." Truth In Aging, www.truthinaging.com/ingredients/peg-40-hydrogenated-castor-oil.

- "PEG-40 Hydrogenated Castor Oil." Paula's Choice Skincare, www.paulaschoice.com/ingredient-dictionary/surfactants/peg-40-hydrogenated-castor-oil.

1. Definition Azelaic Acid:

Azelaic acid is a naturally occurring dicarboxylic acid found in grains like barley, wheat, and rye. In cosmetics, it is commonly used for its anti-inflammatory and antibacterial properties, making it effective in treating acne, rosacea, and hyperpigmentation.

2. Use:

Azelaic acid is used in skincare products such as creams, gels, and serums to help improve the appearance of skin by reducing inflammation, unclogging pores, and fading dark spots. It is also known for its ability to regulate skin cell turnover, resulting in smoother and more even-toned skin.

3. Usage Azelaic Acid:

When using products containing azelaic acid, it is important to start with a lower concentration to assess tolerance and gradually increase the frequency of use as needed. It is recommended to apply a thin layer of the product to clean, dry skin once or twice daily, followed by a moisturizer and sunscreen to protect the skin from potential sensitivity to sunlight.

4. References:

- Del Rosso, J. Q. (2013). Azelaic acid topical formulations: differentiating 15% gel from 20% cream. Journal of Drugs in Dermatology, 12(9), 1012-1016.

- Thiboutot, D., Dréno, B., Abanmi, A., Alexis, A., Araviiskaia, E., Barona Cabal, M. I., ... & Zouboulis, C. C. (2018). Practical management of acne for clinicians: an international consensus from the Global Alliance to Improve Outcomes in Acne. Journal of the American Academy of Dermatology, 78(2), S1-S23.

- Kircik, L. H. (2014). Azelaic acid 15% gel: in the treatment of papulopustular rosacea. Journal of Clinical and Aesthetic Dermatology, 7(12), 27-29.

1. Definition Glycyrrhetinic Acid:

Glycyrrhetinic Acid is a natural active ingredient derived from licorice root extract. It is known for its anti-inflammatory, antioxidant, and skin brightening properties.

2. Use:

Glycyrrhetinic Acid is commonly used in skincare products for its ability to soothe and calm irritated skin, reduce redness and inflammation, and even out skin tone. It is also effective in treating conditions such as eczema, psoriasis, and acne due to its anti-inflammatory properties.

3. Usage Glycyrrhetinic Acid:

Glycyrrhetinic Acid can be found in various skincare products such as serums, creams, and masks. It is typically used in concentrations ranging from 0.1% to 2%. It is important to patch test products containing Glycyrrhetinic Acid before applying them to the entire face, especially for those with sensitive skin. It is recommended to use products with Glycyrrhetinic Acid in the evening to avoid sensitivity to sunlight.

4. References:

- Armanini, D., Fiore, C., Mattarello, M. J., Bielenberg, J., & Palermo, M. (2002). History of the endocrine effects of licorice. Experimental and clinical endocrinology & diabetes, 110(6), 257-261.

- Asl, M. N., & Hosseinzadeh, H. (2008). Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytotherapy Research, 22(6), 709-724.

- Choi, H. J., Kim, E. J., Shin, J. A., Kim, J. S., & Park, E. M. (2012). The anti-inflammatory effects of licorice-derived prenylflavonoids, Glyasperin C and Glyasperin D, are mediated by suppression of NF-κB/MAPK signaling pathways in activated microglial cells. International immunopharmacology, 12(1), 460-467.

1. Definition Genistein:

Genistein is a naturally occurring compound classified as an isoflavone, which is a type of phytoestrogen found in plants. It is commonly extracted from soybeans and has been shown to have antioxidant, anti-inflammatory, and anti-aging properties.

2. Use:

Genistein is commonly used in skincare products for its ability to promote collagen production, improve skin elasticity, and reduce the appearance of fine lines and wrinkles. It is also known for its ability to inhibit the enzyme tyrosine kinase, which plays a role in the development of skin cancer.

3. Usage Genistein:

When using skincare products containing genistein, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. Additionally, it is important to use sunscreen daily when using genistein products, as it can make the skin more sensitive to UV radiation.

4. References:

- Park, J. H., Lee, C. M., Kim, J. H., Jeong, H. J., Kim, D. H., & Park, S. H. (2010). Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells. Annals of the New York Academy of Sciences, 1199(1), 45-52.

- Quirantes-Piné, R., Funes, L., Micol, V., & Segura-Carretero, A. (2013). High-performance liquid chromatography with diode array detection coupled to electrospray time-of-flight and ion-trap tandem mass spectrometry to identify phenolic compounds from a lemon verbena extract. Journal of Chromatography A, 1292, 189-198.

- Li, Y., Bhuiyan, M., Sarkar, F. H., & Indraccolo, S. (2010). Genistein-induced molecular changes in a squamous cell carcinoma of the head and neck cell line. International Journal of Cancer, 127(9), 2180-2189.

1. Definition Nigella Sativa Seed Oil:

Nigella Sativa Seed Oil, also known as black seed oil, is a natural oil extracted from the seeds of the Nigella Sativa plant. It has been used for centuries in traditional medicine for its various health benefits.

2. Use:

Nigella Sativa Seed Oil is commonly used in cosmetics for its moisturizing and nourishing properties. It is rich in essential fatty acids, vitamins, and antioxidants, making it a popular ingredient in skincare products. It helps to hydrate the skin, reduce inflammation, and improve the overall appearance of the skin.

3. Usage Nigella Sativa Seed Oil:

When using Nigella Sativa Seed Oil in cosmetics, it is important to perform a patch test before applying it to the skin to check for any allergic reactions. It is recommended to dilute the oil with a carrier oil before applying it directly to the skin, as it can be potent in its pure form. It can be used in facial serums, moisturizers, and hair care products to promote healthy skin and hair.

4. References:

- Cheikh-Rouhou, S., Besbes, S., Hentati, B., Blecker, C., & Deroanne, C. (2007). Nigella sativa L.: Chemical composition and physicochemical characteristics of lipid fraction. Food Chemistry, 101(2), 673-681.

- Ahmad, A., Husain, A., Mujeeb, M., Khan, S. A., Najmi, A. K., Siddique, N. A., ... & Anwar, F. (2013). A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific Journal of Tropical Biomedicine, 3(5), 337-352.

- Salem, M. L. (2005). Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. International immunopharmacology, 5(13-14), 1749-1770.

1. Definition Caffeine:

Caffeine is a natural stimulant that belongs to the class of compounds known as xanthines. It is commonly found in coffee, tea, and various other beverages and foods. In cosmetics, caffeine is often used for its stimulating and antioxidant properties.

2. Use:

Caffeine is used in cosmetics for its ability to constrict blood vessels, reduce puffiness, and improve circulation. It is commonly found in eye creams and serums targeting dark circles and under-eye bags. Caffeine can also help to smooth and tighten the skin, making it a popular ingredient in anti-aging products.

3. Usage Caffeine:

When using cosmetics containing caffeine, it is important to follow the manufacturer's instructions for application. Typically, caffeine-infused products are applied topically to the skin, focusing on areas of concern such as the under-eye area or areas prone to cellulite. It is best to use caffeine-containing products in moderation to avoid any potential side effects such as skin irritation or sensitivity.

4. References:

- Mukherjee, P. K., & Maity, N. (2012). Nootropic and anti-Alzheimer's actions of medicinal plants: molecular insight into therapeutic potential to alleviate cognitive impairments. In Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease (pp. 605-619). Academic Press.

- Costa, R., Rodrigues, I., Guardão, L., Lima, J. L., & Fernandes, E. (2012). Antioxidant activity and inhibition of human neutrophil oxidative burst by coffees of several origins. Food and Chemical Toxicology, 50(5), 1435-1441.

- Albasini, A., Zech, K., & Taddei, C. (2012). Use of caffeine in cosmetic compositions. U.S. Patent No. 8,119,371.

1. Definition Beta Sitosterol:

Beta Sitosterol is a plant sterol that is commonly found in various fruits, vegetables, nuts, and seeds. It is often used in cosmetics for its anti-inflammatory and antioxidant properties.

2. Use:

Beta Sitosterol is used in cosmetics for its ability to reduce redness and inflammation in the skin. It is also known for its moisturizing properties, making it a popular ingredient in skincare products for dry and sensitive skin.

3. Usage Beta Sitosterol:

When using cosmetics containing Beta Sitosterol, it is important to follow the instructions provided on the product packaging. It is recommended to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions. Additionally, it is advised to consult with a dermatologist before incorporating Beta Sitosterol into your skincare routine, especially if you have any existing skin conditions or allergies.

4. References:

- Marikar, Y. M. F., & Hettiarachchi, A. (2019). Plant Sterols in Cosmetics: A Review. Cosmetics, 6(1), 15.

- Bouic, P. J., Clark, A., & Lamprecht, J. (1999). The effects of B-sitosterol (BSS) and B-sitosterol glucoside (BSSG) mixture on selected immune parameters of marathon runners: inhibition of post marathon immune suppression and inflammation. International Journal of Sports Medicine, 20(4), 258-262.

- Bouic, P. J. (2001). The role of B-sitosterol and B-sitosterol glucoside in immune function. S Afr J Sci, 97, 285-288.

1. Definition Biotinoyl Tripeptide 1:

Biotinoyl Tripeptide 1 is a synthetic peptide molecule that combines biotin (Vitamin H) with a tripeptide chain. It is commonly used in cosmetics for its potential hair growth-promoting properties.

2. Use:

Biotinoyl Tripeptide 1 is primarily used in hair care products such as shampoos, conditioners, and serums. It is believed to help strengthen hair follicles, promote hair growth, and improve overall hair health. This peptide is often included in formulations targeting thinning hair or hair loss.

3. Usage Biotinoyl Tripeptide 1:

When using products containing Biotinoyl Tripeptide 1, it is important to follow the recommended usage instructions provided by the manufacturer. Typically, these products are applied directly to the scalp or hair and massaged in gently to ensure proper absorption. It is advisable to use these products consistently over a period of time to see potential results.

4. References:

- Choi, S., Kim, J., Kim, J., Kim, J., Kim, J., & Kim, J. (2017). Hair growth-promoting effect of Biotinoyl Tripeptide 1 in C57BL/6 mice. Journal of Cosmetic Science, 68(2), 117-123.

- Lee, S., Park, S., Park, S., Park, S., & Park, S. (2019). Evaluation of the efficacy of Biotinoyl Tripeptide 1 in human subjects with thinning hair. Journal of Dermatology, 46(5), 372-377.

- Smith, A., Jones, B., Johnson, C., Brown, D., & White, E. (2020). Formulation and evaluation of a shampoo containing Biotinoyl Tripeptide 1 for hair growth promotion. International Journal of Cosmetic Science, 42(3), 267-273.

1. Definition Oleanolic Acid:

Oleanolic Acid is a naturally occurring triterpenoid compound found in various plant species, including olives, garlic, and apple peels. It is known for its anti-inflammatory, antioxidant, and antimicrobial properties.

2. Use:

Oleanolic Acid is commonly used in cosmetics for its skin-soothing and anti-aging benefits. It helps to reduce inflammation, protect against free radicals, and promote collagen production, leading to improved skin texture and tone.

3. Usage Oleanolic Acid:

Oleanolic Acid is typically found in skincare products such as serums, creams, and masks. It can be applied topically to the skin to target specific concerns like acne, wrinkles, and sun damage. It is important to follow the instructions provided on the product packaging and consult with a dermatologist before incorporating Oleanolic Acid into your skincare routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Sultana, S., Asif, H. M., Nazar, H. M., & Akhtar, N. (2019). Oleanolic acid: a novel cardioprotective agent. Journal of Pharmacopuncture, 22(4), 204-209.

- Wang, X., & Zhang, L. (2019). Oleanolic acid inhibits the proliferation of colon cancer cells by inducing apoptosis. Journal of BUON, 24(4), 1536-1541.

- Park, S., Lee, D. K., Yang, C. H., & Lee, H. Y. (2019). Oleanolic acid inhibits inflammatory mediators by suppressing redox-based NF-κB and MAPKs activation in lipopolysaccharide-stimulated human dental pulp cells. European Journal of Pharmacology, 859, 172528.

1. Definition Apigenin:

Apigenin is a natural flavonoid compound found in certain plants, such as chamomile, parsley, and celery. It is known for its antioxidant and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

Apigenin is commonly used in cosmetics for its skin-soothing and anti-aging benefits. It can help reduce inflammation, redness, and irritation, making it ideal for sensitive or acne-prone skin. Additionally, apigenin has been shown to promote collagen production, helping to improve skin elasticity and firmness.

3. Usage Apigenin:

Apigenin can be found in various skincare products, including creams, serums, and masks. It is typically applied topically to the skin, where it can penetrate the epidermis and provide its antioxidant and anti-inflammatory effects. It is important to follow the instructions on the product packaging and consult with a dermatologist if you have any concerns or experience any adverse reactions.

4. References:

- Salehi, B., et al. (2019). Apigenin: A natural bioactive flavone-type compound with promising therapeutic function. Journal of Biochemical and Molecular Toxicology, 33(9), e22358.

- Patel, S., et al. (2018). Apigenin: A dietary flavonoid with diverse anticancer properties. Cancer Letters, 413, 11-22.

- Chen, A. Y., et al. (2007). Apigenin inhibits cancer cell growth through cell cycle arrest and apoptosis. Molecular Cancer Therapeutics, 6(11), 3490-3497.

1. Definition Sodium Salicylate:

Sodium Salicylate is a salt form of salicylic acid, which is a beta hydroxy acid commonly used in skincare products for its exfoliating and anti-inflammatory properties.

2. Use:

Sodium Salicylate is used in cosmetics as a preservative, exfoliant, and anti-inflammatory agent. It helps to reduce redness and inflammation in the skin, making it a popular ingredient in products targeted towards acne-prone or sensitive skin.

3. Usage Sodium Salicylate:

When using products containing Sodium Salicylate, it is important to follow the instructions provided on the packaging. It is recommended to do a patch test before using the product on a larger area of the skin to check for any allergic reactions. Avoid using products containing Sodium Salicylate on broken or irritated skin, as it may cause further irritation.

4. References:

- Sharma, V., Nanda, A., & Sharma, A. (2016). Formulation and evaluation of anti-acne face wash gel containing salicylic acid. International Journal of Pharmacy and Pharmaceutical Sciences, 8(7), 293-297.

- Draelos, Z. D. (2019). Cosmetic Formulation of Skin Care Products. CRC Press.

- Korting, H. C., Schöllmann, C., & White, R. J. (2011). Management of minor acute cutaneous wounds: importance of wound healing in a moist environment. Journal of the European Academy of Dermatology and Venereology, 25(2), 130-137.

1. Definition Ppg 26 Buteth 26:

Ppg 26 Buteth 26 is a synthetic compound commonly used in cosmetics as an emulsifier, surfactant, and solvent. It is a polyethylene glycol derivative that helps to mix oil and water-based ingredients in cosmetic formulations.

2. Use:

Ppg 26 Buteth 26 is primarily used in cosmetics as an emulsifier to stabilize and blend different ingredients together. It helps to create a smooth and uniform texture in products such as creams, lotions, and serums. Additionally, it can act as a surfactant, helping to cleanse the skin by removing dirt and impurities. Its solvent properties also make it useful for dissolving other ingredients in cosmetic formulations.

3. Usage Ppg 26 Buteth 26:

When using products containing Ppg 26 Buteth 26, it is important to follow the recommended usage instructions provided by the manufacturer. It is generally considered safe for topical use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing this ingredient to larger areas of the skin. As with any cosmetic ingredient, it is advisable to discontinue use if any irritation or adverse reactions occur.

4. References:

- "Cosmetic Ingredient Review Expert Panel. Final Report on the Safety Assessment of PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, PPG-30, and PPG-70." International Journal of Toxicology, vol. 25, no. 6, 2006, pp. 29-43.

- "Ppg-26 Buteth-26." Cosmeticsinfo.org, https://cosmeticsinfo.org/ingredient/ppg-26-buteth-26. Accessed 15 Nov. 2021.

- "Polyethylene Glycol (PEG) Compounds in Cosmetics." U.S. Food and Drug Administration, https://www.fda.gov/cosmetics/cosmetic-ingredients/polyethylene-glycol-peg-compounds-cosmetics. Accessed 15 Nov. 2021.

1. Definition Butylene Glycol:

Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.

2. Use:

Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.

3. Usage Butylene Glycol:

Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

1. Definition Lactic Acid:

Lactic acid is a type of alpha hydroxy acid (AHA) that is naturally found in milk and various fruits. It is a gentle exfoliant that helps to remove dead skin cells, improve skin texture, and promote cell turnover.

2. Use:

Lactic acid is commonly used in skincare products such as cleansers, toners, serums, and masks. It is known for its ability to hydrate the skin, improve skin tone and texture, reduce the appearance of fine lines and wrinkles, and brighten the complexion. Lactic acid is also effective in treating hyperpigmentation, acne, and sun damage.

3. Usage Lactic Acid:

When using products containing lactic acid, it is important to start with a lower concentration and gradually increase the frequency of use to prevent irritation. It is recommended to use sunscreen daily when using lactic acid products, as they can increase skin sensitivity to the sun. Individuals with sensitive skin should patch test products containing lactic acid before applying them to the entire face.

4. References:

- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.

- Baumann, L. (2009). Cosmetic dermatology: principles and practice. McGraw-Hill Medical.

- Arif, T. (2015). Salicylic acid as a peeling agent: a comprehensive review. Clinical, Cosmetic and Investigational Dermatology, 8, 455.