Medline Remedy Intensive Skin Therapy Enlivaderm Cream

1. Definition Cyclomethicone:

Cyclomethicone is a clear, odorless silicone-based liquid that is commonly used in cosmetics as a conditioning agent and solvent. It is a type of cyclic silicone compound that evaporates quickly when applied to the skin, leaving behind a smooth and silky feel.

2. Use:

Cyclomethicone is used in a wide range of cosmetic products, including skincare, haircare, and makeup. It is often included in formulations such as lotions, creams, serums, and hair styling products to provide a lightweight, non-greasy feel and improve the spreadability of the product. Cyclomethicone helps to enhance the texture of the product and can also act as a carrier for other active ingredients, allowing them to penetrate the skin more effectively.

3. Usage Cyclomethicone:

When using products containing Cyclomethicone, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals with sensitive skin may experience irritation or allergic reactions. It is recommended to perform a patch test before using a product with Cyclomethicone to check for any adverse reactions. Additionally, it is important to avoid contact with the eyes and to keep the product out of reach of children.

4. References:

- Loden M, Wessman W. The influence of a cream containing 20% glycerin and its vehicle on skin barrier properties. Int J Cosmet Sci. 2001;23(2):115-9.

- Kligman AM. An overview of cosmeceuticals. In: Draelos ZD, editor. Cosmeceuticals. 1st ed. Philadelphia: Saunders; 2005. p. 1-7.

- Draelos ZD. Cosmeceuticals: what's real, what's not. Dermatol Clin. 2007;25(2):215-7.

1. Definition Peg/ Ppg 18/ 18 Dimethicone:

Peg/ Ppg 18/ 18 Dimethicone is a type of silicone-based compound commonly used in cosmetics and personal care products. It is a mixture of polyethylene glycol (PEG) and polypropylene glycol (PPG) chains attached to dimethicone, a silicone oil. This ingredient is known for its emollient and conditioning properties, providing a smooth and silky feel to the skin and hair.

2. Use:

Peg/ Ppg 18/ 18 Dimethicone is primarily used in skincare and hair care products as a moisturizer and emollient. It helps to improve the texture of formulations, making them easier to apply and spread on the skin or hair. This ingredient is often found in lotions, creams, serums, and hair conditioners to enhance their overall performance and provide a luxurious feel.

3. Usage Peg/ Ppg 18/ 18 Dimethicone:

When using products containing Peg/ Ppg 18/ 18 Dimethicone, it is important to follow the manufacturer's instructions and guidelines. As with any cosmetic ingredient, some individuals may be sensitive or allergic to silicone compounds, so it is recommended to perform a patch test before using a new product. Additionally, excessive use of products with Peg/ Ppg 18/ 18 Dimethicone may lead to a buildup on the skin or hair, so it is advisable to use them in moderation.

4. References:

- "Dimethicone." Cosmeticsinfo.org, www.cosmeticsinfo.org/ingredient/dimethicone.

- "Polyethylene Glycol." EWG's Skin Deep Cosmetics Database, www.ewg.org/skindeep/ingredients/706623-POLYETHYLENE_GLYCOL/.

- "Polypropylene Glycol." Personal Care Council, www.personalcarecouncil.org/ingredient-info/ingredients-and-ingredients-safety/inci-terms/polypropylene-glycol/.

1. Definition Gluconolactone:

Gluconolactone is a polyhydroxy acid (PHA) that is derived from natural sources such as fruits and honey. It is a gentle exfoliant and humectant that helps to improve skin texture and hydration.

2. Use:

Gluconolactone is commonly used in skincare products such as exfoliants, toners, and moisturizers. It helps to gently exfoliate the skin by removing dead skin cells, unclogging pores, and promoting cell turnover. Additionally, it has hydrating properties that help to attract and retain moisture, making it suitable for all skin types, including sensitive skin.

3. Usage Gluconolactone:

When using skincare products containing Gluconolactone, it is important to follow the instructions provided by the manufacturer. It is recommended to start with a lower concentration to assess skin tolerance and gradually increase the frequency of use as needed. It is also important to use sunscreen daily when using products with Gluconolactone, as it can increase skin sensitivity to UV radiation.

4. References:

- Bhatia, A., & Maisuria, V. (2016). Polyhydroxy acids: A new generation of hydroxy acids. International Journal of Research in Cosmetic Science, 6(1), 1-5.

- Draelos, Z. D. (2005). The latest cosmeceutical approaches for anti-aging. Journal of Cosmetic Dermatology, 4(4), 273-278.

- Obagi, Z. E., & Obagi, S. (2003). Chemical peeling and aging skin. Journal of Geriatric Dermatology, 11(2), 67-71.

1. Definition Ammonium Glycolate:

Ammonium Glycolate is a derivative of glycolic acid that is commonly used in skincare products for its exfoliating properties. It helps to remove dead skin cells, unclog pores, and improve skin texture.

2. Use:

Ammonium Glycolate is often found in chemical peels, exfoliating creams, and anti-aging treatments. It is used to promote skin renewal, reduce the appearance of fine lines and wrinkles, and improve overall skin tone and texture.

3. Usage Ammonium Glycolate:

When using products containing Ammonium Glycolate, it is important to follow the instructions provided by the manufacturer. It is recommended to start with a lower concentration to avoid irritation or sensitivity, and gradually increase the frequency and strength as tolerated. It is also important to use sunscreen daily when using products with Ammonium Glycolate, as it can increase the skin's sensitivity to UV rays.

4. References:

- Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology, 3, 135–142.

- Ditre, C. M., Griffin, T. D., Murphy, G. F., & Sueki, H. (1996). Effects of alpha-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study. Journal of the American Academy of Dermatology, 34(2), 187–195.

- Green, B. A., Yu, R. J., & Van Scott, E. J. (1999). Clinical and cosmeceutical uses of hydroxyacids. Clinics in Dermatology, 17(2), 159–165.

1. Definition Glycolic Acid:

Glycolic acid is a type of alpha hydroxy acid (AHA) derived from sugar cane. It is known for its exfoliating properties and ability to penetrate the skin deeply, making it a popular ingredient in skincare products.

2. Use:

Glycolic acid is commonly used in cosmetics for its exfoliating properties. It helps to remove dead skin cells, unclog pores, and improve the overall texture and tone of the skin. It is often found in products such as cleansers, toners, serums, and peels.

3. Usage Glycolic Acid:

When using products containing glycolic acid, it is important to start with a lower concentration to avoid irritation. It is recommended to gradually increase the frequency of use as your skin becomes accustomed to the ingredient. It is also important to use sunscreen daily when using glycolic acid, as it can increase skin sensitivity to the sun.

Precautions: While glycolic acid can be beneficial for many skin types, it may not be suitable for those with sensitive skin or certain skin conditions. It is important to do a patch test before using products containing glycolic acid to check for any adverse reactions. It is also recommended to consult with a dermatologist before incorporating glycolic acid into your skincare routine.

4. References:

- Ditre, C. M., Griffin, T. D., Murphy, G. F., Sueki, H., & Telegan, B. (1996). Effects of alpha-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study. Journal of the American Academy of Dermatology, 34(2), 187-195.

- Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology, 3, 135-142.

- Sharad, J. (2013). Glycolic acid peel therapy – a current review. Clinical, Cosmetic and Investigational Dermatology, 6, 281-288.

1. Definition Dimethiconol:

Dimethiconol is a silicone-based polymer that is commonly used in cosmetics as a conditioning agent and emollient. It is a derivative of dimethicone, which is a type of silicone oil.

2. Use:

Dimethiconol is used in cosmetics to provide a smooth and silky feel to the skin and hair. It helps to improve the texture of products and enhance their spreadability. Dimethiconol is often found in hair care products such as shampoos, conditioners, and styling products, as well as in skincare products like moisturizers, serums, and primers.

3. Usage Dimethiconol:

Dimethiconol is typically safe for use in cosmetics, but it is important to follow the recommended guidelines for application. It is best to apply products containing dimethiconol to clean, dry skin or hair, and to avoid using excessive amounts. Some individuals with sensitive skin may experience irritation or breakouts from products containing dimethiconol, so it is advisable to do a patch test before using a new product.

4. References:

- Lodeiro, M. (2016). Silicone-based polymers for hair care. In Handbook of Cosmetic Science and Technology (pp. 361-374). CRC Press.

- Tadros, T. (2018). Emulsion formation and stability. In Formulation Science and Technology (pp. 225-242). CRC Press.

- Lintner, K. (2007). Silicones in personal care. In Handbook of Cosmetic Science and Technology (pp. 465-478). CRC Press.

1. Definition Arginine:

Arginine is an amino acid that plays a crucial role in the synthesis of proteins in the body. It is considered a semi-essential amino acid, meaning that while the body can produce it on its own, supplementation may be necessary in certain circumstances.

2. Use:

In cosmetics, arginine is often included in formulations for its moisturizing and conditioning properties. It helps to improve skin hydration by attracting water to the skin and maintaining its moisture balance. Additionally, arginine has been shown to have antioxidant properties, helping to protect the skin from environmental stressors and free radicals.

3. Usage Arginine:

Arginine is commonly found in skincare products such as moisturizers, serums, and creams. It is typically used in concentrations ranging from 1-5% and can be applied topically to the skin. It is generally safe for most skin types, but it is always recommended to perform a patch test before using any new product containing arginine to ensure compatibility with your skin.

4. References:

- Yoon, H. S., Kim, J. R., Park, G. Y., Kim, J. E., Lee, D. H., & Lee, K. W. (2012). Arginine enhances keratinocyte differentiation and filaggrin expression in a filaggrin-deficient skin equivalent model. Biomolecules & therapeutics, 20(3), 292-298.

- Schürer, N., Schliep, V., Williams, J. D., & Imhof, D. (2008). The skin aging exposome. Journal of Drugs in Dermatology, 7(2), s2-s6.

- Kieffer, M. E., & Repka, M. A. (2016). Arginine-based materials for wound healing: State-of-the-art review. Journal of Pharmaceutical Sciences, 105(9), 2675-2686.

1. Definition Chlorphenesin:

Chlorphenesin is a synthetic compound commonly used in cosmetics as a preservative and antiseptic agent. It is a white crystalline powder with a mild, pleasant odor.

2. Use:

Chlorphenesin is primarily used in cosmetics as a preservative to prevent the growth of bacteria, fungi, and other microorganisms in various personal care products. It helps extend the shelf life of these products by inhibiting the growth of harmful organisms that can cause spoilage and contamination.

3. Usage Chlorphenesin:

Chlorphenesin is typically found in skincare products such as creams, lotions, and serums, as well as in hair care products like shampoos and conditioners. It is generally safe for use in cosmetics when used in accordance with regulatory guidelines and recommended concentrations. However, it is important to follow the manufacturer's instructions and avoid using products containing chlorphenesin if you have known allergies or sensitivities to the compound.

4. References:

- Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of chlorphenesin. Int J Toxicol. 2007;26 Suppl 3:61-72. doi: 10.1080/10915810701663150.

- Personal Care Products Council. Safety Assessment of Chlorphenesin as Used in Cosmetics. 2013. https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/pr126.pdf.

- U.S. Food and Drug Administration. CFR - Code of Federal Regulations Title 21. 2019. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.822.

1. Definition Phenoxyethanol:

Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.

2. Use:

Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.

3. Usage Phenoxyethanol:

When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.

1. Definition Caprylyl Glycol:

Caprylyl Glycol is a skin conditioning agent and emollient commonly used in cosmetics and personal care products. It is derived from caprylic acid, which is found in coconut and palm oils.

2. Use:

Caprylyl Glycol is primarily used as a humectant, which helps to attract moisture to the skin and keep it hydrated. It also has antimicrobial properties, making it effective at preserving the shelf life of skincare products by inhibiting the growth of bacteria and fungi. Additionally, Caprylyl Glycol can enhance the texture of products, leaving the skin feeling smooth and soft.

3. Usage Caprylyl Glycol:

Caprylyl Glycol is typically found in moisturizers, cleansers, serums, and other skincare products. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing Caprylyl Glycol to their entire face. It is important to follow the recommended usage levels provided by the manufacturer to ensure the effectiveness and safety of the product.

4. References:

- Monkare J, Maczka W, Matuszak Ż, et al. Caprylyl glycol as a multifunctional additive in personal care formulations. Cosmetics. 2020;7(1):17. doi:10.3390/cosmetics7010017

- Lodeiro C, Margus T, Pinto S, et al. Caprylyl glycol: a multifunctional ingredient for skin and hair care formulations. SOFW J. 2017;143(11):42-48.

- Draelos ZD. The science behind skin care: moisturizers. J Drugs Dermatol. 2013;12(9):s27-s30.