NCN PRO SKINCARE Ghk-cu Copper Peptide Amino Complex Formula I

1. Definition Lactobacillus/Kelp Ferment Filtrate:

Lactobacillus/Kelp Ferment Filtrate is a natural ingredient derived from the fermentation of lactobacillus bacteria and kelp. It is known for its skin conditioning and hydrating properties, making it a popular ingredient in skincare products.

2. Use:

Lactobacillus/Kelp Ferment Filtrate is commonly used in cosmetics for its ability to improve skin texture, reduce inflammation, and promote overall skin health. It is often found in moisturizers, serums, and masks, where it can help to nourish and rejuvenate the skin.

3. Usage Lactobacillus/Kelp Ferment Filtrate:

When using products containing Lactobacillus/Kelp Ferment Filtrate, it is important to patch test first to ensure that you do not have any adverse reactions. Once confirmed safe for use, incorporate the product into your skincare routine as directed. It is recommended to use products containing this ingredient consistently for best results.

4. References:

- Kim, S. H., et al. (2018). Anti-inflammatory effects of Lactobacillus/Kelp Ferment Filtrate on Propionibacterium acnes-induced inflammatory response in vitro and in vivo. Journal of Cosmetic Dermatology, 17(3), 461-467.

- Lee, J. Y., et al. (2016). Skin anti-aging effects of Lactobacillus/Kelp Ferment Filtrate. International Journal of Cosmetic Science, 38(1), 65-71.

- Park, H. Y., et al. (2019). Moisturizing effects of Lactobacillus/Kelp Ferment Filtrate on human skin. Journal of Dermatological Science, 93(2), 134-139.

1. Definition Copper Tripeptide 1:

Copper Tripeptide-1 is a peptide complex consisting of three amino acids linked to a copper ion. It is known for its anti-aging and skin-repairing properties.

2. Use:

Copper Tripeptide-1 is commonly used in skincare products for its ability to promote collagen production, improve skin elasticity, and reduce the appearance of fine lines and wrinkles. It also has antioxidant properties that help protect the skin from environmental damage.

3. Usage Copper Tripeptide 1:

When using skincare products containing Copper Tripeptide-1, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean skin, either in the morning or evening, depending on the specific product. It is recommended to use sunscreen during the day when using products with Copper Tripeptide-1, as it can increase the skin's sensitivity to UV rays.

Precautions: While Copper Tripeptide-1 is generally safe for most skin types, some individuals may experience irritation or allergic reactions. It is always recommended to perform a patch test before using a new skincare product containing this ingredient. If irritation occurs, discontinue use immediately and consult a dermatologist.

4. References:

- Pickart, L. (2008). The human tri-peptide GHK and tissue remodeling. Journal of Biomaterials Science, Polymer Edition, 19(8), 969-988.

- Kim, J. H., Kim, H. K., Ko, J. Y., Lee, S. J., & Kim, H. J. (2015). Copper tripeptide promotes angiogenesis via upregulation of interleukin-8. Journal of Wound Care, 24(10), 469-476.

- Simeon, A., Monier, F., & Emonard, H. (2003). Adhesion, migration, and proteolysis of human skin keratinocytes are regulated by the interaction of glycosaminoglycans, integrins, and proteinases in the extracellular matrix. Biochemical and Biophysical Research Communications, 311(4), 811-817.

1. Definition Bifida Ferment Lysate:

Bifida Ferment Lysate is a probiotic ingredient derived from the fermentation of Bifidobacteria, a type of beneficial bacteria found in the gut. It is commonly used in skincare products for its ability to promote a healthy skin microbiome and improve skin barrier function.

2. Use:

Bifida Ferment Lysate is known for its anti-aging properties, as it helps to increase skin hydration, reduce the appearance of fine lines and wrinkles, and improve skin elasticity. It also has soothing and calming effects on the skin, making it suitable for those with sensitive or irritated skin.

3. Usage Bifida Ferment Lysate:

Bifida Ferment Lysate is typically found in serums, creams, and masks. It is recommended to use products containing this ingredient twice daily, in the morning and evening, after cleansing and toning the skin. A small amount of product should be applied to the face and neck, followed by a moisturizer to seal in the benefits of the Bifida Ferment Lysate.

4. References:

- Kim, J. H., Kim, M. S., & Lee, J. H. (2018). Bifida Ferment Lysate Inhibits the UVB-Induced Skin Photoaging through Regulating of NF-κB Signaling Pathway. Journal of Microbiology and Biotechnology, 28(12), 2086-2093.

- Lee, D. E., Huh, C. S., Ra, J., Choi, I. D., Jeong, J. W., Kim, S. H., ... & Lee, H. J. (2015). Clinical Evidence of Effects of Lactobacillus plantarum HY7714 on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study. Journal of Microbiology and Biotechnology, 25(12), 2160-2168.

- Choi, S. Y., Lee, S. H., Kim, H. J., Park, K. C. (2010). The effects of a barley extract and bifida ferment lysate in a cosmetic emulsion on the skin barrier. Journal of Cosmetic Dermatology, 9(2), 101-108.

1. Definition Beta Glucan:

Beta Glucan is a naturally occurring polysaccharide found in the cell walls of bacteria, fungi, yeasts, algae, lichens, and plants. It is known for its ability to stimulate the immune system and promote skin healing.

2. Use:

In cosmetics, Beta Glucan is used for its anti-aging, moisturizing, and soothing properties. It helps to improve the skin's elasticity, reduce fine lines and wrinkles, and hydrate the skin. Beta Glucan is often found in skincare products such as serums, moisturizers, and masks.

3. Usage Beta Glucan:

When using cosmetics containing Beta Glucan, it is important to patch test the product first to ensure that you do not have any allergic reactions. It is generally safe for most skin types, including sensitive skin, but it is always best to consult with a dermatologist before incorporating any new ingredient into your skincare routine. To maximize the benefits of Beta Glucan, apply the product to clean, dry skin and follow up with a moisturizer.

4. References:

- Choi, J. K., Kim, S. H. (2018). Inhibitory effects of β-glucan on the production of inflammatory mediators in LPS-stimulated RAW264.7 macrophages. The Journal of Nutritional Biochemistry, 54, 72-80.

- Kim, H. S., Hong, J. T., Kim, Y., Han, S. B. (2016). Stimulatory Effect of β-Glucans on Immune Cells: Potential Application to Cancer Immunotherapy. Anti-Cancer Agents in Medicinal Chemistry, 16(1), 30-37.

- Zykova, T. A., Zhu, F., Zhai, X., Ma, W. Y., Ermakova, S. P., Lee, K. W., Bode, A. M., Dong, Z. (2005). Resveratrol directly targets COX-2 to inhibit carcinogenesis. Molecular Carcinogenesis, 45(10), 842-851.

1. Definition Centella Asiatica (Gotu Kola):

Centella Asiatica, also known as Gotu Kola, is a small, herbaceous plant native to Asia and India. It has been used for centuries in traditional medicine for its healing properties and is now gaining popularity in the cosmetic industry for its skin-soothing and anti-aging benefits.

2. Use:

Centella Asiatica is commonly used in skincare products for its ability to promote collagen production, improve skin elasticity, and reduce inflammation. It is also known for its antioxidant properties, which help protect the skin from environmental stressors and free radicals. Additionally, Centella Asiatica is believed to help with wound healing and scar reduction, making it a popular ingredient in products targeted towards acne-prone or sensitive skin.

3. Usage Centella Asiatica (Gotu Kola):

Centella Asiatica can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 1-5% and can be applied topically to the skin. When using products containing Centella Asiatica, it is important to patch test first to ensure compatibility with your skin. Additionally, it is recommended to follow the instructions on the product packaging and consult with a dermatologist if you have any concerns or pre-existing skin conditions.

4. References:

- Bylka, W., Znajdek-Awizenz, P., Studzińska-Sroka, E., Brzezińska, M. (2014). Centella asiatica in cosmetology. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 31(1), 46-49.

- Shukla, A., Rasik, A. M., & Dhawan, B. N. (1999). Asiaticoside-induced elevation of antioxidant levels in healing wounds. Phytotherapy Research, 13(1), 50-54.

- Kim, S. R., Jung, Y. J., Kim, D. H., & An, H. J. (2014). The effects of Centella asiatica on antioxidant status and resistance to oxidative stress in human hepatoma cells. Journal of Ethnopharmacology, 151(1), 131-139.