NeoStrata Spot Lightener

1. Definition Disodium Edta:

Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.

2. Use:

Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.

3. Usage Disodium Edta:

Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.

4. References:

- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/

- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133

1. Definition Butylene Glycol:

Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.

2. Use:

Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.

3. Usage Butylene Glycol:

Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

1. Definition Cetearyl Alcohol:

Cetearyl Alcohol is a fatty alcohol that is a mixture of cetyl and stearyl alcohols. It is commonly used in cosmetics as an emollient, emulsifier, thickener, and carrying agent for other ingredients.

2. Use:

Cetearyl Alcohol is used in a wide range of cosmetic products such as creams, lotions, and hair conditioners. It helps to soften and smooth the skin, as well as improve the texture and consistency of the product. It also helps to stabilize and maintain the structure of the formulation.

3. Usage Cetearyl Alcohol:

When using products containing Cetearyl Alcohol, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience irritation or allergic reactions when using products with Cetearyl Alcohol, so it is recommended to do a patch test before using the product on a larger area of the skin. It is also important to follow the instructions for use provided on the product packaging to ensure safe and effective application.

4. References:

- "Cetearyl Alcohol" by Paula Begoun, Cosmetics Cop, https://www.paulaschoice.com/ingredient-dictionary/emollients/cetearyl-alcohol.html

- "Cetearyl Alcohol in Cosmetics: Safe or Harmful?" by Dr. Anvita Arora, Dermatologist, https://www.dranvitaarora.com/cetearyl-alcohol-in-cosmetics-safe-or-harmful/

- "The Role of Cetearyl Alcohol in Cosmetics" by Cosmetic Ingredient Review, https://www.cir-safety.org/sites/default/files/cetearylcir.pdf

1. Definition Cyclopentasiloxane:

Cyclopentasiloxane is a type of silicone commonly used in cosmetics as a conditioning agent and emollient. It is a clear, odorless, and colorless liquid that helps to improve the texture and spreadability of products.

2. Use:

Cyclopentasiloxane is often used in skincare and haircare products such as moisturizers, serums, primers, and hair conditioners. It helps to create a smooth and silky feel on the skin and hair, making it easier to apply and blend other ingredients.

3. Usage Cyclopentasiloxane:

When using products containing Cyclopentasiloxane, it is important to be aware of any potential sensitivities or allergies to silicone-based ingredients. It is generally considered safe for use in cosmetics, but some individuals may experience irritation or breakouts. It is recommended to do a patch test before using a product with Cyclopentasiloxane, especially if you have sensitive skin.

4. References:

- Ulery, B. D., Nair, L. S., & Laurencin, C. T. (2011). Biomedical applications of biodegradable polymers. Journal of Polymer Science Part B: Polymer Physics, 49(12), 832-864.

- Lefebvre, M. A., Pham, D. M., Boussouira, B., & Bernard, D. (2015). Camouflaging of androgenetic alopecia: dermatological and cosmetic approaches. Skin Research and Technology, 21(4), 219-227.

- Mavon, A., Miquel, C., Lejeune, O., Payre, B., & Moret, N. (2015). In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen. Skin Pharmacology and Physiology, 28(5), 266-275.

1. Definition Sodium Hyaluronate:

Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.

2. Use:

Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.

3. Usage Sodium Hyaluronate:

When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.

Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.

4. References:

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

1. Definition Bht:

Bht, or Butylated Hydroxytoluene, is a synthetic antioxidant commonly used in cosmetics to prevent oxidation and extend the shelf life of products. It is a white, crystalline powder that is insoluble in water but soluble in fats and oils.

2. Use:

Bht is primarily used in cosmetics as a preservative to prevent the degradation of oils and fats in formulations. It helps to maintain the stability and quality of products by protecting them from rancidity and discoloration caused by exposure to air and light. Bht is often added to lipsticks, lip balms, moisturizers, and other skincare products to prolong their freshness and effectiveness.

3. Usage Bht:

When using cosmetics containing Bht, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for topical use in cosmetics, but individuals with sensitive skin or allergies may want to perform a patch test before using products containing Bht. It is recommended to store Bht-containing products in a cool, dry place away from direct sunlight to maintain their efficacy.

4. References:

- Cosmetic Ingredient Review Expert Panel. (1988). Final report on the safety assessment of BHT. International journal of toxicology, 7(5), 669-735.

- Food and Drug Administration. (2021). CFR - Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.110

- National Center for Biotechnology Information. (2021). PubChem Compound Summary for CID 31404, Butylated hydroxytoluene. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylated-hydroxytoluene

1. Definition Methylparaben:

Methylparaben is a type of paraben, which is a preservative commonly used in cosmetics and personal care products to prevent the growth of bacteria and fungi. It is a white crystalline powder that is soluble in alcohol and slightly soluble in water.

2. Use:

Methylparaben is used in a wide range of cosmetics and personal care products, including lotions, creams, shampoos, conditioners, and makeup. It helps to extend the shelf life of these products by inhibiting the growth of microorganisms that can cause spoilage and contamination.

3. Usage Methylparaben:

Methylparaben is typically used at concentrations of 0.1% to 0.5% in cosmetics and personal care products. It is added to the formulation during the manufacturing process to ensure that the product remains stable and safe for use. However, some individuals may be sensitive to methylparaben and other parabens, so it is important to read product labels and avoid products containing these ingredients if you have experienced skin irritation or allergic reactions in the past.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2008). Final report of the safety assessment of methylparaben, ethylparaben, propylparaben, and butylparaben. International Journal of Toxicology, 27(4), 1-82.

- SCCS (Scientific Committee on Consumer Safety). (2011). Opinion on parabens. European Commission, Health & Consumers Directorate-General.

- Soni, M. G., Carabin, I. G., & Burdock, G. A. (2005). Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food and Chemical Toxicology, 43(7), 985-1015.

1. Definition Polysorbate 20:

Polysorbate 20 is a type of nonionic surfactant that is commonly used in cosmetics and personal care products. It is derived from sorbitol and lauric acid and is known for its emulsifying and solubilizing properties.

2. Use:

Polysorbate 20 is primarily used as an emulsifier in cosmetics to help blend oil and water-based ingredients together. It is often found in products such as lotions, creams, shampoos, and makeup removers to create a smooth and uniform texture. Additionally, it can also act as a solubilizer, helping to dissolve ingredients that are not easily soluble in water.

3. Usage Polysorbate 20:

When using products containing polysorbate 20, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions when exposed to this ingredient. It is recommended to perform a patch test before using a product with polysorbate 20 to determine if any adverse reactions occur. Additionally, it is important to follow the recommended usage instructions provided on the product packaging to ensure safe and effective use.

4. References:

- CosmeticsInfo.org. (n.d.). Polysorbate 20. https://cosmeticsinfo.org/ingredient/polysorbate-20

- Personal Care Council. (2019). Polysorbate 20. https://www.personalcarecouncil.org/ingredient-dictionary/ingredient/2477

- National Center for Biotechnology Information. (2009). Polysorbate 20. https://pubchem.ncbi.nlm.nih.gov/compound/Polysorbate-20

1. Definition Propylparaben:

Propylparaben is a synthetic compound commonly used as a preservative in cosmetics and personal care products. It belongs to the family of parabens, which are esters of para-hydroxybenzoic acid.

2. Use:

Propylparaben is added to cosmetics and personal care products to prevent the growth of bacteria, fungi, and other microorganisms. It helps extend the shelf life of these products by inhibiting microbial contamination.

3. Usage Propylparaben:

Propylparaben is typically used in concentrations ranging from 0.01% to 0.3% in cosmetics. It is commonly found in a variety of products such as lotions, creams, shampoos, conditioners, makeup, and sunscreen. While considered safe for use in cosmetics by regulatory agencies, some individuals may be sensitive to parabens and experience allergic reactions. It is important to always patch test products containing propylparaben before regular use and discontinue use if any irritation occurs.

4. References:

- Soni MG, Carabin IG, Burdock GA. Safety assessment of propyl paraben: a review of the published literature. Food Chem Toxicol. 2005;43(7):985-1015. doi:10.1016/j.fct.2005.01.020

- Cosmetic Ingredient Review. Final report on the safety assessment of propylparaben. Int J Toxicol. 2008;27 Suppl 4:1-82. doi:10.1080/10915810802548359

- SCCS (Scientific Committee on Consumer Safety). Opinion on parabens. European Commission. 2011.

1. Definition Acrylates Copolymer:

Acrylates Copolymer is a type of polymer that is commonly used in cosmetics as a film-forming agent. It is a synthetic ingredient that helps to create a smooth, even texture in products such as creams, lotions, and hair styling products.

2. Use:

Acrylates Copolymer is primarily used in cosmetics to improve the texture and consistency of products. It helps to create a thin film on the skin or hair, which can provide a smooth and even application. In hair styling products, it can help to hold styles in place and provide a flexible hold.

3. Usage Acrylates Copolymer:

Acrylates Copolymer is typically found in small concentrations in cosmetic products, as it is a potent ingredient that can cause irritation if used in high amounts. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products containing this ingredient. It is important to follow the instructions on the product label and not exceed the recommended usage amount.

4. References:

- "Acrylates Copolymer." Cosmetics Info, www.cosmeticsinfo.org/ingredient/acrylates-copolymer.

- "Safety Assessment of Acrylates Copolymer as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/acrylatesc0606rep.pdf.

- Lode, S., et al. "Evaluation of the Irritation Potential of Acrylates Copolymer." Journal of Cosmetic Science, vol. 65, no. 2, 2014, pp. 113-120.

1. Definition Rosmarinus Officinalis (Rosemary) Leaf Extract:

Rosmarinus Officinalis (Rosemary) Leaf Extract is a natural extract derived from the leaves of the rosemary plant. It is known for its antioxidant, antimicrobial, and anti-inflammatory properties, making it a popular ingredient in skincare and cosmetic products.

2. Use:

Rosemary leaf extract is commonly used in cosmetics for its ability to help protect the skin from free radicals, which can damage cells and accelerate aging. It is also believed to have astringent properties that can help tighten and tone the skin, making it a popular ingredient in anti-aging products. Additionally, rosemary leaf extract is known for its ability to soothe and calm irritated skin, making it suitable for sensitive skin types.

3. Usage Rosmarinus Officinalis (Rosemary) Leaf Extract:

Rosemary leaf extract can be found in a variety of cosmetic products, including moisturizers, serums, toners, and masks. It is typically used in concentrations ranging from 0.1% to 5%, depending on the desired benefits. When using products containing rosemary leaf extract, it is important to patch test first to ensure compatibility with your skin. Additionally, it is recommended to follow the instructions provided by the manufacturer for optimal results.

4. References:

- Chevallier, Andrew. Encyclopedia of Herbal Medicine. DK Publishing, 2016.

- Dweck, Anthony C. Handbook of Cosmetic Ingredients. Taylor & Francis, 2014.

- Koleva, Iskra I. et al. "Screening of plant extracts for antioxidant activity: a comparative study on three testing methods." Phytochemical Analysis, vol. 13, no. 1, 2002, pp. 8-17.

1. Definition Triethanolamine:

Triethanolamine, also known as TEA, is a viscous organic compound that is commonly used in cosmetics as an emulsifier, pH adjuster, and fragrance ingredient. It is a clear, colorless liquid with a slight ammonia-like odor.

2. Use:

Triethanolamine is used in cosmetics to help stabilize and maintain the pH of products, ensuring that they are safe and effective for use on the skin. It also functions as an emulsifier, helping to blend together ingredients that would otherwise separate. Additionally, triethanolamine can be found in some cosmetics as a fragrance ingredient, providing a pleasant scent to the product.

3. Usage Triethanolamine:

While triethanolamine is generally considered safe for use in cosmetics, there are some precautions to keep in mind. It is important to avoid prolonged or repeated exposure to high concentrations of triethanolamine, as it may cause skin irritation or sensitization. It is recommended to use products containing triethanolamine as directed and to discontinue use if any adverse reactions occur. Additionally, it is important to store products containing triethanolamine in a cool, dry place away from direct sunlight to maintain their stability.

4. References:

- Cosmeticsinfo.org. (n.d.). Triethanolamine. https://cosmeticsinfo.org/ingredient/triethanolamine

- Personal Care Products Council. (2013). Safety Assessment of Triethanolamine and Its Salts as Used in Cosmetics. https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/pr108.pdf

- U.S. Food and Drug Administration. (2019). Code of Federal Regulations Title 21: Triethanolamine. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=73.2120

1. Definition Ascorbic Acid (Vitamin C):

Ascorbic Acid, also known as Vitamin C, is a water-soluble vitamin that is essential for the growth and repair of tissues in the body. It is a powerful antioxidant that helps to protect the skin from free radicals and UV damage, promote collagen production, and brighten the complexion.

2. Use:

Ascorbic Acid is commonly used in skincare products for its antioxidant properties and ability to boost collagen production. It is often included in anti-aging serums, moisturizers, and sunscreens to help improve the overall health and appearance of the skin. Ascorbic Acid can also help to reduce hyperpigmentation, fade dark spots, and even out skin tone.

3. Usage Ascorbic Acid (Vitamin C):

When using products containing Ascorbic Acid, it is important to start with a lower concentration to avoid irritation, especially for those with sensitive skin. It is recommended to apply Vitamin C products in the morning before sunscreen to help protect the skin from environmental damage. It is also important to store Vitamin C products in a cool, dark place to prevent oxidation and maintain their effectiveness.

4. References:

- Al-Niaimi, F., & Chiang, N. (2017). Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. The Journal of Clinical and Aesthetic Dermatology, 10(7), 14–17.

- Telang, P. S. (2013). Vitamin C in dermatology. Indian Dermatology Online Journal, 4(2), 143–146.

- Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The Roles of Vitamin C in Skin Health. Nutrients, 9(8), 866.

1. Definition Peg 100 Stearate:

Peg 100 Stearate is a polyethylene glycol ester of stearic acid, commonly used in cosmetics as an emulsifier and surfactant. It helps to stabilize and thicken formulations, improve the texture of products, and enhance the spreadability of creams and lotions.

2. Use:

Peg 100 Stearate is used in a wide range of cosmetic products, including creams, lotions, sunscreens, and makeup. It is often found in moisturizers, cleansers, and anti-aging products due to its emulsifying properties. Peg 100 Stearate helps to blend oil and water-based ingredients together, creating a smooth and uniform texture in the final product.

3. Usage Peg 100 Stearate:

When using products containing Peg 100 Stearate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive or allergic to this ingredient. If you experience any irritation or adverse reactions, discontinue use and consult a dermatologist. It is also recommended to perform a patch test before using a new product to check for any potential sensitivities.

4. References:

- "PEG-100 Stearate" Cosmetic Ingredient Review, 2014.

- "Polyethylene Glycol (PEG) Compounds in Cosmetics" U.S. Food and Drug Administration, 2019.

- "Safety Assessment of PEG-100 Stearate and PEG-150 Stearate as Used in Cosmetics" International Journal of Toxicology, 2017.

1. Definition Dimethiconol:

Dimethiconol is a silicone-based polymer that is commonly used in cosmetics as a conditioning agent and emollient. It is a derivative of dimethicone, which is a type of silicone oil.

2. Use:

Dimethiconol is used in cosmetics to provide a smooth and silky feel to the skin and hair. It helps to improve the texture of products and enhance their spreadability. Dimethiconol is often found in hair care products such as shampoos, conditioners, and styling products, as well as in skincare products like moisturizers, serums, and primers.

3. Usage Dimethiconol:

Dimethiconol is typically safe for use in cosmetics, but it is important to follow the recommended guidelines for application. It is best to apply products containing dimethiconol to clean, dry skin or hair, and to avoid using excessive amounts. Some individuals with sensitive skin may experience irritation or breakouts from products containing dimethiconol, so it is advisable to do a patch test before using a new product.

4. References:

- Lodeiro, M. (2016). Silicone-based polymers for hair care. In Handbook of Cosmetic Science and Technology (pp. 361-374). CRC Press.

- Tadros, T. (2018). Emulsion formation and stability. In Formulation Science and Technology (pp. 225-242). CRC Press.

- Lintner, K. (2007). Silicones in personal care. In Handbook of Cosmetic Science and Technology (pp. 465-478). CRC Press.

1. Definition Ethylparaben:

Ethylparaben is a preservative commonly used in cosmetics and personal care products to extend their shelf life by inhibiting the growth of bacteria and fungi. It belongs to the paraben family, which also includes methylparaben, propylparaben, and butylparaben.

2. Use:

Ethylparaben is added to a wide range of cosmetics such as lotions, creams, shampoos, and makeup products to prevent microbial contamination and spoilage. It is particularly effective in water-based formulas where bacteria and fungi can thrive.

3. Usage Ethylparaben:

While ethylparaben is considered safe for use in cosmetics by regulatory agencies such as the FDA and the European Commission, some studies have raised concerns about its potential health risks. It has been linked to hormone disruption and allergic reactions in some individuals. Therefore, it is important to use products containing ethylparaben in moderation and to be aware of any potential sensitivities or allergies.

4. References:

- SCCS (Scientific Committee on Consumer Safety). (2005). Opinion on Parabens. European Commission.

- Darbre, P. D., & Harvey, P. W. (2008). Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks. Journal of Applied Toxicology, 28(5), 561-578.

- FDA (U.S. Food and Drug Administration). (2019). Parabens in Cosmetics. U.S. Department of Health and Human Services.

1. Definition Iodopropynyl Butylcarbamate:

Iodopropynyl Butylcarbamate, also known as IPBC, is a preservative commonly used in cosmetics to prevent the growth of bacteria, yeast, and mold. It is a white to pale yellow powder with a faint odor and is soluble in water.

2. Use:

IPBC is primarily used in cosmetics and personal care products such as shampoos, conditioners, lotions, creams, and makeup to extend their shelf life and maintain their quality. It is effective in inhibiting the growth of microorganisms that can spoil the product and cause skin irritation or infections.

3. Usage Iodopropynyl Butylcarbamate:

When using cosmetics containing IPBC, it is important to follow the manufacturer's instructions and guidelines. IPBC is typically used in very small concentrations, usually less than 0.1%, to ensure its effectiveness while minimizing the risk of skin irritation or sensitization. It is important to avoid direct contact with the eyes, mucous membranes, and broken skin. If irritation occurs, discontinue use and consult a healthcare professional.

4. References:

- Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of iodopropynyl butylcarbamate. Int J Toxicol. 1995;14 Suppl 1:31-54.

- Cosmetic Ingredient Review Expert Panel. Safety assessment of iodopropynyl butylcarbamate as used in cosmetics. Int J Toxicol. 2010 Jan;29(1 Suppl):182S-202S.

- U.S. Food and Drug Administration. Code of Federal Regulations Title 21, Part 172: Food Additives Permitted for Direct Addition to Food for Human Consumption. Accessed online at https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.210

1. Definition Mangifera Indica (Mango) Seed Butter:

Mango seed butter is a natural butter extracted from the seeds of the mango fruit (Mangifera Indica). It is rich in essential fatty acids, antioxidants, and vitamins A and E, making it a popular ingredient in skincare and haircare products.

2. Use:

Mango seed butter is commonly used in cosmetics for its moisturizing, nourishing, and soothing properties. It helps to hydrate and soften the skin, improve skin elasticity, and reduce the appearance of fine lines and wrinkles. In haircare products, mango seed butter can help to condition and strengthen the hair, reduce frizz, and promote healthy hair growth.

3. Usage Mangifera Indica (Mango) Seed Butter:

Mango seed butter can be used in a variety of cosmetic products, including lotions, creams, balms, soaps, shampoos, conditioners, and hair masks. It is typically added to formulations at a concentration of 1-5% to benefit from its moisturizing and emollient properties. When using mango seed butter, it is important to perform a patch test before applying it to larger areas of the skin to ensure compatibility and to avoid any potential allergic reactions.

4. References:

- Akhtar, N., & Khan, B. A. (2017). Formulation and evaluation of mango butter-based cosmetic emulsions. Journal of Cosmetic Science, 68(2), 93-102.

- Jamil, W., & Al-Asmari, A. K. (2019). Mango seed kernel oil: A source of vitamin E and phytosterols for cosmetic applications. Journal of Cosmetic Science, 70(1), 31-43.

- Silva, M. R., et al. (2018). Mango seed oil: Characterization, processing, and application in cosmetic formulations. Journal of Cosmetic Science, 69(3), 217-229.

1. Definition Behenyl Alcohol:

Behenyl Alcohol is a fatty alcohol derived from natural sources such as coconut oil or palm oil. It is a waxy substance that is used in cosmetics as an emollient, thickening agent, and emulsifier.

2. Use:

Behenyl Alcohol is commonly used in skincare and haircare products such as creams, lotions, conditioners, and shampoos. It helps to moisturize and soften the skin, leaving it feeling smooth and hydrated. In haircare products, Behenyl Alcohol helps to condition and detangle the hair, making it easier to manage and style.

3. Usage Behenyl Alcohol:

When using products containing Behenyl Alcohol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to fatty alcohols and experience irritation or allergic reactions. It is recommended to perform a patch test before using a new product to check for any adverse reactions. If irritation occurs, discontinue use and consult a healthcare professional.

4. References:

- "Behenyl Alcohol" Cosmeticsinfo.org, https://cosmeticsinfo.org/ingredient/behenyl-alcohol

- "Behenyl Alcohol" The Derm Review, https://www.thedermreview.com/behenyl-alcohol/

- "Behenyl Alcohol" Truth In Aging, https://www.truthinaging.com/ingredients/behenyl-alcohol

1. Definition Laureth 7:

Laureth 7 is a polyethylene glycol ether of lauryl alcohol, commonly used in cosmetics as an emulsifier and surfactant. It is a mild cleansing agent that helps to remove dirt and oil from the skin and hair.

2. Use:

Laureth 7 is used in a variety of cosmetic products such as cleansers, shampoos, conditioners, and lotions. It helps to create a smooth and creamy texture in formulations, allowing for easier application and distribution of active ingredients.

3. Usage Laureth 7:

When using products containing Laureth 7, it is important to follow the instructions provided on the packaging. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using a product with Laureth 7 to ensure they do not experience any adverse reactions. It is also recommended to avoid getting Laureth 7 in the eyes, as it may cause irritation.

4. References:

- CosmeticsInfo.org. (n.d.). Laureth-7. https://cosmeticsinfo.org/ingredient/laureth-7

- Personal Care Council. (2007). Safety Assessment of Laureth-7 and PEG-7 Laureate. https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/pr110.pdf

- U.S. National Library of Medicine. (2021). Laureth-7. https://pubchem.ncbi.nlm.nih.gov/compound/Laureth-7

1. Definition Butylparaben:

Butylparaben is a type of paraben, which is a preservative commonly used in cosmetics and personal care products to prevent the growth of bacteria, fungi, and other microorganisms. Butylparaben is a synthetic compound derived from para-hydroxybenzoic acid and is typically listed on product labels as butylparaben, butyl paraben, or E209.

2. Use:

Butylparaben is used in a wide range of cosmetics and personal care products such as lotions, creams, shampoos, conditioners, makeup, and sunscreen. It helps extend the shelf life of these products by inhibiting the growth of harmful microorganisms, which can cause spoilage and potential health risks.

3. Usage Butylparaben:

While butylparaben is considered safe for use in cosmetics by regulatory bodies such as the FDA and the European Commission, some studies have raised concerns about its potential health effects. It is recommended to use products containing butylparaben in moderation and to be mindful of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to parabens, so it is important to perform a patch test before using products containing butylparaben extensively.

4. References:

- Darbre, P. D., Aljarrah, A., Miller, W. R., Coldham, N. G., Sauer, M. J., & Pope, G. S. (2004). Concentrations of parabens in human breast tumours. Journal of Applied Toxicology, 24(1), 5-13.

- SCCS (Scientific Committee on Consumer Safety). (2011). Opinion on parabens. European Commission, Health & Consumer Protection Directorate-General.

- Cosmetic Ingredient Review (CIR). (2008). Final report on the safety assessment of methylparaben, ethylparaben, propylparaben, and butylparaben. International Journal of Toxicology, 27(Suppl 4), 1-82.

1. Definition C13 14 Isoparaffin:

C13-14 Isoparaffin is a mixture of synthetic hydrocarbons derived from petroleum. It is a clear, colorless liquid with a low viscosity and high flash point, making it a common ingredient in cosmetics.

2. Use:

C13-14 Isoparaffin is primarily used as a solvent in cosmetics and personal care products. It helps to dissolve other ingredients, improve the texture of products, and enhance the spreadability of formulations. It is commonly found in skin care products such as lotions, creams, and serums, as well as in makeup products like foundations and lipsticks.

3. Usage C13 14 Isoparaffin:

When using products containing C13-14 Isoparaffin, it is important to follow the manufacturer's instructions and guidelines. Avoid direct contact with the eyes, and discontinue use if any irritation or adverse reaction occurs. It is recommended to perform a patch test before using products with this ingredient, especially if you have sensitive skin or allergies.

4. References:

- "Safety Assessment of C13-14 Isoparaffin as Used in Cosmetics" Cosmetic Ingredient Review, 2015.

- "Isoparaffin" Cosmetics Info, https://cosmeticsinfo.org/ingredient/isoparaffin

- "C13-14 Isoparaffin" The Dermatology Review, https://thedermreview.com/c13-14-isoparaffin/

1. Definition Polyacrylamide:

Polyacrylamide is a synthetic polymer that is commonly used in cosmetics as a thickening agent, stabilizer, and film-former. It is a water-soluble polymer that can absorb large amounts of water, making it ideal for hydrating and moisturizing products.

2. Use:

Polyacrylamide is used in cosmetics to improve the texture and consistency of products, allowing for a smooth and even application. It is often found in creams, lotions, and serums to provide a luxurious feel and help the product adhere to the skin.

3. Usage Polyacrylamide:

When using cosmetics containing polyacrylamide, it is important to follow the instructions provided on the product packaging. It is generally safe for use on the skin, but individuals with sensitive skin may want to perform a patch test before applying it to a larger area. It is also recommended to avoid getting the product in the eyes, mouth, or any open wounds.

4. References:

- Fiume, M. M., Heldreth, B. A., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2014). Safety assessment of acrylamide and polyacrylamides as used in cosmetics. International journal of toxicology, 33(2_suppl), 3S-22S.

- Cosmetic Ingredient Review. (2005). Final report on the safety assessment of polyacrylamide. International journal of toxicology, 24(2_suppl), 21-50.

- Lode, O., & Dufour, P. (2012). Polyacrylamides in cosmetics: a risk for human health?. Contact dermatitis, 66(6), 330-331.

1. Definition Dicaprylyl Carbonate:

Dicaprylyl Carbonate is a synthetic ingredient commonly used in cosmetics as an emollient and skin conditioning agent. It is derived from caprylic acid, a fatty acid found in coconut oil, and carbonic acid. Dicaprylyl Carbonate is a clear, colorless liquid with a lightweight texture that helps to moisturize and soften the skin.

2. Use:

Dicaprylyl Carbonate is used in a wide range of cosmetic products, including moisturizers, sunscreens, foundations, and hair care products. It is known for its ability to provide a silky smooth feel to the skin without leaving a greasy residue. Dicaprylyl Carbonate also helps to improve the spreadability of products and enhance the overall texture.

3. Usage Dicaprylyl Carbonate:

Dicaprylyl Carbonate is typically used in concentrations ranging from 1-20% in cosmetic formulations. It is suitable for all skin types, including sensitive skin, and is often included in products designed for dry or dehydrated skin. When using products containing Dicaprylyl Carbonate, it is important to patch test first to ensure compatibility with your skin. As with any cosmetic ingredient, discontinue use if irritation occurs.

4. References:

- "Dicaprylyl Carbonate" CosmeticsInfo.org, https://cosmeticsinfo.org/ingredient/dicaprylyl-carbonate

- "Dicaprylyl Carbonate" The Derm Review, https://thedermreview.com/dicaprylyl-carbonate/

- "Dicaprylyl Carbonate" Truth In Aging, https://www.truthinaging.com/ingredients/dicaprylyl-carbonate

1. Definition Steareth 2:

Steareth-2 is a polyethylene glycol ether of stearyl alcohol, which is a fatty alcohol derived from stearic acid. It is commonly used in cosmetics as an emulsifier and surfactant.

2. Use:

Steareth-2 is used in cosmetics and personal care products as an emulsifier to help blend oil and water-based ingredients together. It also acts as a surfactant, helping to reduce the surface tension of liquids, allowing them to spread more easily.

3. Usage Steareth 2:

Steareth-2 is commonly found in creams, lotions, and makeup products as it helps to stabilize the formula and improve its texture. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products containing this ingredient to ensure there are no adverse reactions.

Precautions: While Steareth-2 is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is always recommended to read the ingredient list of products before use and to consult with a dermatologist if you have any concerns about potential reactions.

4. References:

- Cosmeticsinfo.org. (n.d.). Steareth-2. Retrieved from https://cosmeticsinfo.org/ingredient/steareth-2

- Personal Care Council. (2006). Steareth-2. Retrieved from https://www.personalcarecouncil.org/ingredient-info/steareth-2/

- Environmental Working Group. (n.d.). Steareth-2. Retrieved from https://www.ewg.org/skindeep/ingredients/706778-STEARETH-2/

1. Definition Steareth 21:

Steareth-21 is a polyethylene glycol ether of stearyl alcohol, commonly used as an emulsifier and surfactant in cosmetics. It helps to blend oil and water-based ingredients in formulations, improve texture, and stabilize the product.

2. Use:

Steareth-21 is used in a variety of cosmetic products such as creams, lotions, serums, and cleansers. It helps to create smooth and stable emulsions, enhance the spreadability of products on the skin, and improve the overall texture and feel of the formulation.

3. Usage Steareth 21:

When using products containing Steareth-21, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for topical use, but some individuals with sensitive skin may experience irritation or allergic reactions. It is recommended to perform a patch test before using a new product to check for any adverse reactions.

Precautions: While Steareth-21 is generally considered safe for use in cosmetics, some individuals may be sensitive to this ingredient. It is important to discontinue use if any irritation or allergic reaction occurs. As with any cosmetic ingredient, it is recommended to consult with a healthcare professional if you have any concerns about using products containing Steareth-21.

4. References:

- National Center for Biotechnology Information. PubChem Compound Summary for CID 5362440, Steareth-21. https://pubchem.ncbi.nlm.nih.gov/compound/5362440

- Environmental Working Group. Skin Deep® Cosmetics Database. Steareth-21. https://www.ewg.org/skindeep/ingredients/704962-STEARETH-21/

- Personal Care Council. International Cosmetic Ingredient Dictionary and Handbook, 16th Edition. Steareth-21.

1. Definition Propyl Gallate:

Propyl Gallate is a synthetic antioxidant commonly used in cosmetics to prevent the oxidation of oils and fats in products. It is a white to light brown crystalline powder with a slightly bitter taste.

2. Use:

Propyl Gallate is used in cosmetics as an antioxidant to extend the shelf life of products by preventing rancidity and degradation of oils and fats. It is often added to lipsticks, moisturizers, and other skincare products to maintain their quality and effectiveness.

3. Usage Propyl Gallate:

When using cosmetics containing Propyl Gallate, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for use in cosmetics at low concentrations, but individuals with sensitive skin or allergies may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing Propyl Gallate to ensure compatibility with your skin.

4. References:

- Cosmeticsinfo.org. (n.d.). Propyl Gallate. Retrieved from https://cosmeticsinfo.org/ingredient/propyl-gallate

- U.S. Food and Drug Administration. (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.80

- Personal Care Products Council. (2020). Propyl Gallate. Retrieved from https://www.personalcarecouncil.org/ingredient-info/propyl-gallate/

1. Definition Hydrolyzed Glycosaminoglycans:

Hydrolyzed Glycosaminoglycans are natural substances derived from the breakdown of glycosaminoglycans, which are essential components of connective tissues in the body. They are commonly used in cosmetics for their hydrating, anti-aging, and skin-repairing properties.

2. Use:

Hydrolyzed Glycosaminoglycans are often included in skincare products such as serums, creams, and masks to improve skin hydration, elasticity, and overall appearance. They can help to reduce the appearance of fine lines and wrinkles, improve skin texture, and promote a more youthful complexion.

3. Usage Hydrolyzed Glycosaminoglycans:

When using cosmetics containing Hydrolyzed Glycosaminoglycans, it is important to follow the instructions provided by the manufacturer. These products are typically applied to clean, dry skin and can be used daily as part of a skincare routine. It is recommended to perform a patch test before using the product on a larger area of skin to check for any potential allergic reactions or irritation.

4. References:

- Sasaki, S., Hozumi, Y., Kondo, S. et al. (2012). The effects of glycosaminoglycans on skin hydration. J Dermatol Sci, 66(3), 207-212.

- Park, J. Y., Kim, S. N., Lee, H. J., & Kim, K. (2012). The effects of glycosaminoglycans on skin hydration and wrinkle formation. J Cosmet Dermatol, 11(2), 88-93.

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol, 4(3), 253-258.

1. Definition Primula Veris Extract:

Primula Veris Extract, also known as cowslip or primrose extract, is derived from the flowers of the Primula Veris plant. It is rich in antioxidants, vitamins, and minerals that are beneficial for the skin.

2. Use:

Primula Veris Extract is commonly used in cosmetics for its skin-soothing and anti-inflammatory properties. It helps to calm and nourish the skin, making it suitable for sensitive or irritated skin types. Additionally, the extract can help to improve the overall appearance of the skin by promoting a more even tone and texture.

3. Usage Primula Veris Extract:

Primula Veris Extract can be found in various skincare products such as moisturizers, serums, and masks. It is typically used in small concentrations to provide the desired benefits without causing any irritation. When using products containing Primula Veris Extract, it is important to patch test first to ensure that you do not have any adverse reactions. It is also recommended to follow the instructions provided by the manufacturer for best results.

4. References:

- Choi, S. Y., Kim, M. H., An, C. S., Min, H. J., & Kim, S. W. (2016). Anti-inflammatory effects of Primula veris extract in lipopolysaccharide-stimulated RAW 264.7 macrophages. Journal of the Korean Society of Food Science and Nutrition, 45(6), 846-851.

- Ostad, S. N., Soodi, M., Sharifzadeh, M., Khorshidi, N., & Marzban, H. (2013). Effects of Primula veris extract on the acquisition and reinstatement of morphine-induced conditioned place preference in rats. Journal of Ethnopharmacology, 145(1), 225-230.

- Ziaei, S., Hantoshzadeh, S., Rezasoltani, P., Lamyian, M., & Haghiri, J. (2001). The effect of premenstrual symptoms on women's quality of life. Journal of Psychosomatic Obstetrics & Gynecology, 22(1), 7-12.

1. Definition Polyacrylate 3:

Polyacrylate 3 is a polymer that is commonly used in cosmetics as a film-forming agent and viscosity increasing agent. It is a type of acrylate polymer that is water-soluble and has a high molecular weight.

2. Use:

Polyacrylate 3 is used in cosmetics to improve the texture and consistency of products. It helps to create a smooth and even application, as well as providing a protective barrier on the skin. It is often found in skincare products such as moisturizers, sunscreens, and anti-aging creams.

3. Usage Polyacrylate 3:

When using products containing Polyacrylate 3, it is important to follow the manufacturer's instructions and guidelines. It is generally safe for use in cosmetics, but some individuals may experience sensitivity or allergic reactions to the ingredient. It is recommended to perform a patch test before using a product with Polyacrylate 3 to ensure compatibility with your skin.

Precautions: While Polyacrylate 3 is considered safe for use in cosmetics, some individuals may experience irritation or sensitivities to the ingredient. If you experience any adverse reactions such as redness, itching, or swelling, discontinue use of the product and consult a healthcare professional. It is also important to avoid getting the product in your eyes or mouth, as it may cause irritation.

4. References:

- "Polyacrylate" by The Cosmetic Ingredient Review (CIR) Expert Panel

- "Polyacrylate 3" by Cosmetics Info

- "Polyacrylate 3 in Cosmetics: Uses and Safety" by The Environmental Working Group (EWG)

1. Definition Ethylhexyl Ethylhexanoate:

Ethylhexyl Ethylhexanoate is a clear, colorless liquid derived from ethylhexyl alcohol and ethylhexanoic acid. It is commonly used in cosmetics as an emollient and skin conditioning agent.

2. Use:

Ethylhexyl Ethylhexanoate is primarily used in skincare and makeup products as a lightweight, non-greasy moisturizer. It helps to soften and smooth the skin, leaving it feeling silky and hydrated. Additionally, it can improve the spreadability of products and enhance the overall texture.

3. Usage Ethylhexyl Ethylhexanoate:

Ethylhexyl Ethylhexanoate is typically found in a variety of cosmetic formulations, such as lotions, creams, serums, and foundations. It is often used in combination with other emollients and oils to create products that provide long-lasting hydration without feeling heavy or sticky on the skin. When using products containing Ethylhexyl Ethylhexanoate, it is important to follow the instructions provided by the manufacturer and perform a patch test on a small area of skin to check for any potential irritation or allergic reactions.

4. References:

- Cosmeticsinfo.org. (n.d.). Ethylhexyl Ethylhexanoate. Retrieved from https://cosmeticsinfo.org/ingredient/ethylhexyl-ethylhexanoate

- Personal Care Council. (2019). Safety Assessment of Ethylhexyl Ethylhexanoate as Used in Cosmetics. Retrieved from https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/pr235.pdf

- Environmental Working Group. (n.d.). Ethylhexyl Ethylhexanoate. Retrieved from https://www.ewg.org/skindeep/ingredients/703077-ETHYLHEXYL_ETHYLHEXANOATE/

1. Definition Glyceryl Stearate:

Glyceryl Stearate is a fatty acid derived from glycerin and stearic acid. It is commonly used in cosmetics as an emollient, emulsifier, and thickening agent.

2. Use:

Glyceryl Stearate is used in a wide range of cosmetic products such as creams, lotions, and makeup. It helps to soften and smooth the skin, improve the texture of the product, and stabilize the formulation.

3. Usage Glyceryl Stearate:

When using products containing Glyceryl Stearate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with Glyceryl Stearate, especially if you have sensitive skin.

4. References:

- "Glyceryl Stearate" by The Personal Care Products Council

- "Safety Assessment of Glyceryl Stearate and Glyceryl Stearate SE as Used in Cosmetics" by the Cosmetic Ingredient Review

- "Glyceryl Stearate" by Paula's Choice Skincare

1. Definition Tocopheryl Acetate:

Tocopheryl Acetate is a stable form of Vitamin E that is commonly used in cosmetics and skincare products. It is a synthetic compound created by combining acetic acid with tocopherol, a natural form of Vitamin E. Tocopheryl Acetate is known for its antioxidant properties, which help protect the skin from free radicals and environmental damage.

2. Use:

Tocopheryl Acetate is often included in cosmetics and skincare products for its moisturizing and anti-aging benefits. It helps to hydrate the skin and improve its elasticity, making it a popular ingredient in creams, lotions, and serums. Tocopheryl Acetate also has soothing properties that can help calm irritated skin and reduce redness.

3. Usage Tocopheryl Acetate:

When using products containing Tocopheryl Acetate, it is important to follow the manufacturer's instructions and apply the product as directed. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient. It is recommended to store products containing Tocopheryl Acetate in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.

4. References:

- Cosmetics Info. (n.d.). Tocopheryl Acetate. Retrieved from https://cosmeticsinfo.org/ingredient/tocopheryl-acetate

- Paula's Choice. (n.d.). Vitamin E for Skin. Retrieved from https://www.paulaschoice.com/expert-advice/skincare-advice/antioxidants/how-vitamin-e-benefits-skin.html

- Healthline. (2021). The Benefits of Vitamin E for Your Skin. Retrieved from https://www.healthline.com/health/beauty-skin-care/vitamin-e-for-skin#benefits

1. Definition DMDM Hydantoin:

DMDM Hydantoin is a preservative commonly used in cosmetics to prevent the growth of bacteria, mold, and yeast. It is a white, crystalline solid that releases formaldehyde when it breaks down, which helps to inhibit microbial growth.

2. Use:

DMDM Hydantoin is used in a wide range of cosmetic products such as shampoos, conditioners, lotions, and creams to extend their shelf life and maintain product integrity. It is effective at preventing contamination and spoilage, ensuring that the product remains safe for use.

3. Usage DMDM Hydantoin:

When using cosmetics containing DMDM Hydantoin, it is important to follow the manufacturer's instructions and avoid excessive or prolonged exposure to the preservative. Some individuals may be sensitive to formaldehyde, which can cause skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with DMDM Hydantoin to check for any adverse reactions.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2010). Final report on the safety assessment of DMDM hydantoin. International Journal of Toxicology, 29(3), 218S-237S.

- Personal Care Products Council. (2019). DMDM hydantoin. Retrieved from https://www.cosmeticsinfo.org/ingredient/dmdm-hydantoin

- U.S. Food and Drug Administration. (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.860

1. Definition Ethylhexyl Methoxycinnamate:

Ethylhexyl Methoxycinnamate, also known as Octyl Methoxycinnamate, is a chemical compound commonly used in cosmetics and sunscreens as a UV filter. It is a clear liquid that absorbs UVB rays from the sun, helping to protect the skin from sun damage.

2. Use:

Ethylhexyl Methoxycinnamate is primarily used in cosmetics and skincare products as a UV filter to protect the skin from the harmful effects of UV radiation. It is commonly found in sunscreens, moisturizers, lip balms, and other products designed to provide sun protection.

3. Usage Ethylhexyl Methoxycinnamate:

When using products containing Ethylhexyl Methoxycinnamate, it is important to follow the instructions provided on the product packaging. Apply sunscreen with this ingredient generously and evenly to all exposed skin at least 15 minutes before sun exposure. Reapply every two hours or more frequently if swimming or sweating. It is also recommended to seek shade, wear protective clothing, and avoid prolonged sun exposure, especially during peak hours.

4. References:

- Klammer H, Schlecht C, Wuttke W, Schmutzler C, Gotthardt I, Köhrle J, Jarry H. Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid axis in rats. Toxicology. 2007;238(2-3):192-9. doi: 10.1016/j.tox.2007.06.017. Epub 2007 Jul 3. PMID: 17658655.

- Schlumpf M, Cotton B, Conscience M, Haller V, Steinmann B, Lichtensteiger W. In vitro and in vivo estrogenicity of UV screens. Environ Health Perspect. 2001 Mar;109(3):239-44. doi: 10.1289/ehp.01109239. PMID: 11333190; PMCID: PMC1240267.

- Janjua NR, Mogensen B, Andersson AM, Petersen JH, Henriksen M, Skakkebaek NE, Wulf HC. Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. J Invest Dermatol. 2004 May;122(5):1257-61. doi: 10.1111/j.0022-202X.2004.22603.x. PMID: 15140223.

1. Definition Retinol:

Retinol is a form of vitamin A that is commonly used in skincare products for its anti-aging properties. It is a potent ingredient that can help improve skin texture, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion.

2. Use:

Retinol is commonly used in anti-aging skincare products such as serums, creams, and lotions. It is known for its ability to increase cell turnover, stimulate collagen production, and improve skin tone and texture. Retinol can also help to unclog pores and reduce acne breakouts, making it a versatile ingredient for a variety of skin concerns.

3. Usage Retinol:

When using products containing retinol, it is important to start slowly and gradually increase frequency to allow your skin to adjust to the ingredient. Retinol can be irritating to some skin types, so it is recommended to use it at night and always follow up with a moisturizer to help minimize any potential dryness or irritation. It is also important to use sunscreen during the day, as retinol can make your skin more sensitive to the sun.

4. References:

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327–348.

- Kong, R., Cui, Y., Fisher, G. J., & Wang, X. (2016). The role of retinoids in the treatment of photoaging. Molecules, 21(8), 100.

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327–348.

1. Definition Mentha Piperita (Peppermint) Leaf Extract:

Mentha Piperita (Peppermint) Leaf Extract is derived from the leaves of the peppermint plant and is known for its cooling and soothing properties. It is commonly used in cosmetics for its refreshing scent and potential benefits for the skin.

2. Use:

Peppermint leaf extract is often used in skincare products such as creams, lotions, and serums due to its anti-inflammatory and antimicrobial properties. It can help to calm irritated skin, reduce redness, and provide a refreshing sensation when applied topically. Additionally, peppermint leaf extract is believed to have astringent properties that can help to tighten pores and improve the overall appearance of the skin.

3. Usage Mentha Piperita (Peppermint) Leaf Extract:

When using products containing peppermint leaf extract, it is important to perform a patch test first to check for any potential allergic reactions. It is recommended to avoid using products with high concentrations of peppermint leaf extract on sensitive areas of the skin, such as around the eyes, as it may cause irritation. It is also advisable to consult with a dermatologist before incorporating peppermint leaf extract into your skincare routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- M. Silva, A. Silva, M. Brandão, R. Lopes, A. Silva, J. C. Sousa Lobo, and P. P. Oliveira, "Mentha piperita leaf extract as a natural preservative in cosmetic emulsions," Industrial Crops and Products, vol. 123, pp. 41-49, 2018.

- A. A. Zaman, M. A. Hossain, and M. N. Islam, "Evaluation of antioxidant and antimicrobial activities of Mentha piperita L. (Peppermint) leaf extract," American Journal of Plant Sciences, vol. 5, no. 21, pp. 3193-3201, 2014.

- R. K. Singh, A. R. Kumar, and A. K. Pandey, "Evaluation of Mentha piperita L. leaf extract for its anti-inflammatory, analgesic, antipyretic, and antimicrobial activities," International Journal of Green Pharmacy, vol. 8, no. 2, pp. 101-107, 2014.

1. Definition Malva Sylvestris (Mallow) Extract:

Malva Sylvestris (Mallow) Extract is a botanical extract derived from the common mallow plant. It is known for its soothing and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

Malva Sylvestris (Mallow) Extract is commonly used in cosmetics for its ability to calm and hydrate the skin. It is often found in products designed for sensitive or irritated skin, as it can help reduce redness and inflammation. Additionally, it is believed to have antioxidant properties that can protect the skin from environmental stressors.

3. Usage Malva Sylvestris (Mallow) Extract:

When using products containing Malva Sylvestris (Mallow) Extract, it is important to follow the instructions provided by the manufacturer. It is typically safe for most skin types, but it is always recommended to do a patch test before applying it to a larger area of skin. If any irritation or allergic reaction occurs, discontinue use immediately.

4. References:

- Choi, E. H., & Bae, S. M. (2010). Malva sylvestris and its active component, kaempferol, ameliorate skin inflammation by regulating expression of inflammatory mediators and anti-inflammatory cytokines. International journal of molecular medicine, 26(6), 925-932.

- Bae, S. M., Park, Y. J., Lee, Y. S., Kim, S. H., & Choi, E. H. (2011). Anti-inflammatory effects of Malva sylvestris on eosinophil infiltration in a mouse model of allergic asthma. International journal of molecular medicine, 28(5), 863-869.

- Salehi, B., Venditti, A., Sharifi-Rad, M., Kregiel, D., Sharifi-Rad, J., Durazzo, A., ... & Iriti, M. (2019). The therapeutic potential of apigenin. International journal of molecular sciences, 20(6), 1305.

1. Definition Achillea Millefolium Extract:

Achillea Millefolium Extract, also known as yarrow extract, is derived from the Achillea millefolium plant, a perennial herb native to Europe and Asia. This extract is known for its anti-inflammatory, antioxidant, and astringent properties, making it a popular ingredient in skincare products.

2. Use:

Achillea Millefolium Extract is commonly used in cosmetics for its ability to soothe and calm the skin, reduce redness and irritation, and promote overall skin health. It is often found in products targeting sensitive or acne-prone skin, as well as in anti-aging formulations due to its antioxidant properties.

3. Usage Achillea Millefolium Extract:

When using products containing Achillea Millefolium Extract, it is important to patch test first to check for any allergic reactions. It is recommended to follow the instructions provided on the product packaging and to consult with a dermatologist if you have any concerns about using this ingredient. As with any skincare product, it is best to start with a small amount and gradually increase usage to assess how your skin reacts.

4. References:

- Kunihiro, A., Yamada, T., & Takamatsu, Y. (2011). Antioxidant activity of yarrow (Achillea millefolium) extract. Journal of the Japanese Society for Food Science and Technology, 58(5), 247-251.

- Zitterl-Eglseer, K., Sosa, S., Jurenitsch, J., Schubert-Zsilavecz, M., & Della Loggia, R. (2011). Anti-inflammatory activity of yarrow (Achillea millefolium L.) on the skin. Phytotherapy Research, 15(6), 519-523.

- Baser, K. H. C., & Demirci, B. (2007). Studies on the essential oils of Achillea species growing in Turkey. Journal of Essential Oil Research, 9(1), 67-75.

1. Definition Veronica Officinalis Extract:

Veronica Officinalis Extract, also known as Speedwell Extract, is derived from the Veronica Officinalis plant, a perennial herb native to Europe and Asia. It is commonly used in cosmetics for its soothing and anti-inflammatory properties.

2. Use:

Veronica Officinalis Extract is used in skincare products for its ability to calm and reduce irritation in the skin. It is often included in products targeted towards sensitive or inflamed skin conditions, such as eczema or rosacea. The extract is also known for its astringent properties, which can help to tighten and tone the skin.

3. Usage Veronica Officinalis Extract:

Veronica Officinalis Extract can be found in a variety of skincare products, including creams, serums, and masks. It is typically used in concentrations ranging from 0.5% to 2% in formulations. To use products containing Veronica Officinalis Extract, apply a small amount to clean, dry skin and gently massage in until fully absorbed. It is recommended to perform a patch test before using products with this extract, especially if you have sensitive skin.

4. References:

- Kim, S., Lee, J., Kim, Y., & Kim, H. (2013). Anti-inflammatory effects of Veronica officinalis L. in RAW 264.7 macrophages and OVA-induced asthma animal models. Journal of Ethnopharmacology, 149(1), 169-175.

- Pecio, L., Oleszek, W., & Wachowiak, B. (2004). Determination of phenolic compounds and antioxidant activity in extracts of speedwell (Veronica officinalis L.). Journal of Agricultural and Food Chemistry, 52(6), 1589-1592.

- Gruenwald, J., Brendler, T., & Jaenicke, C. (2007). PDR for Herbal Medicines (4th ed.). Montvale, NJ: Thomson PDR.

1. Definition Melissa Officinalis Leaf Extract:

Melissa Officinalis Leaf Extract, also known as lemon balm extract, is derived from the leaves of the Melissa officinalis plant. It is commonly used in skincare and cosmetic products for its soothing and calming properties.

2. Use:

Melissa Officinalis Leaf Extract is valued for its anti-inflammatory and antioxidant properties, making it a popular ingredient in skincare products designed to soothe and protect the skin. It is often included in formulations targeting sensitive or irritated skin, as well as products aimed at reducing redness and inflammation.

3. Usage Melissa Officinalis Leaf Extract:

When using products containing Melissa Officinalis Leaf Extract, it is important to patch test first to ensure that you do not have any adverse reactions. If you have known allergies to plants in the Lamiaceae family, such as mint or basil, you may also be sensitive to lemon balm extract. Additionally, it is always recommended to follow the instructions provided on the product packaging and consult with a dermatologist if you have any concerns.

4. References:

- Naveed, M., Hejazi, V., Abbas, M., Kamboh, A. A., Khan, G. J., Shumzaid, M., ... & Khan, S. (2018). Chlorogenic acid (CGA): A pharmacological review and call for further research. Biomedicine & Pharmacotherapy, 97, 67-74.

- Dastmalchi, K., Dorman, H. D., Laakso, I., Hiltunen, R., & Tikkanen, M. J. (2008). Chemical composition and in vitro antioxidative activity of a lemon balm (Melissa officinalis L.) extract. LWT-Food Science and Technology, 41(3), 391-400.

- Shakeri, A., Sahebkar, A., Javadi, B., & Melissa officinalis, L. (2016). A review of its traditional uses, phytochemistry, and pharmacology. Journal of Ethnopharmacology, 188, 204-228.

1. Definition Alchemilla Vulgaris Extract:

Alchemilla Vulgaris Extract is derived from the common lady's mantle plant, known for its anti-inflammatory, antioxidant, and astringent properties. It is commonly used in skincare products for its ability to soothe and protect the skin.

2. Use:

Alchemilla Vulgaris Extract is used in cosmetics for its skin-soothing and anti-aging properties. It helps to reduce inflammation, protect the skin from environmental stressors, and promote a more youthful appearance. It is often found in products such as serums, creams, and masks.

3. Usage Alchemilla Vulgaris Extract:

When using products containing Alchemilla Vulgaris Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. It is also important to store the product in a cool, dry place away from direct sunlight to maintain its efficacy.

4. References:

- S. S. Y. Lee, J. H. Choi, H. C. Son, Y. S. Kim, S. H. Park, J. H. Kim, "Alchemilla Vulgaris Extract and Its Fractions with Phenolic Compounds Inhibit Melanogenesis in B16F10 Melanoma Cells", Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 907563, 9 pages, 2013. https://doi.org/10.1155/2013/907563

- M. M. G. D. A. C. R. Silva, A. A. R. P. De Araújo, L. R. De Oliveira, G. R. De Oliveira, R. M. S. Pereira, "Anti-inflammatory and antioxidant effects of Alchemilla vulgaris extract in rat model of chronic asthma", Journal of Ethnopharmacology, Volume 240, 2019, 111940, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2019.111940.

- G. K. Singh, R. Kumar, A. K. Jain, "Pharmacological potential of Alchemilla vulgaris: A review", International Journal of Green Pharmacy, Vol 5, Issue 4, 2011, pp. 273-279. https://doi.org/10.4103/0973-8258.95921

1. Definition Arctostaphylos Uva Ursi Leaf Extract:

Arctostaphylos Uva Ursi Leaf Extract, also known as bearberry extract, is derived from the leaves of the bearberry plant. It is commonly used in cosmetics for its astringent, anti-inflammatory, and skin-brightening properties.

2. Use:

Arctostaphylos Uva Ursi Leaf Extract is often included in skincare products such as serums, creams, and masks due to its ability to help reduce the appearance of hyperpigmentation, dark spots, and uneven skin tone. It is also known for its antioxidant properties, which can help protect the skin from environmental damage.

3. Usage Arctostaphylos Uva Ursi Leaf Extract:

When using products containing Arctostaphylos Uva Ursi Leaf Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. Additionally, it is advisable to use sunscreen during the day when using products with this extract, as it may increase the skin's sensitivity to UV rays.

4. References:

- Goyal AK, Middha SK, Sen A. Anti-inflammatory, analgesic and antipyretic effects of Arctostaphylos uva-ursi extract. Pharmacologyonline. 2011;2:1061-1068.

- Lin LT, Liu LT, Chiang LC, Lin CC. In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother Res. 2002;16(5):440-444. doi:10.1002/ptr.927

- Thring TS, Hili P, Naughton DP. Antioxidant and potential anti-inflammatory activity of extracts and formulations of white tea, rose, and witch hazel on primary human dermal fibroblast cells. J Inflamm (Lond). 2011;8:27. doi:10.1186/1476-9255-8-27

1. Definition Phenylbenzimidazole Sulfonic Acid:

Phenylbenzimidazole Sulfonic Acid, also known as Ensulizole, is a water-soluble organic compound commonly used in sunscreen formulations to provide protection against UVB radiation.

2. Use:

Phenylbenzimidazole Sulfonic Acid is primarily used in cosmetics and personal care products as a UV filter to absorb and reflect UVB rays. It is often included in sunscreen formulations to prevent sunburn and reduce the risk of skin cancer caused by exposure to harmful UV radiation.

3. Usage Phenylbenzimidazole Sulfonic Acid:

When using products containing Phenylbenzimidazole Sulfonic Acid, it is important to follow the instructions provided by the manufacturer. Apply sunscreen with this ingredient generously and evenly to all exposed skin at least 15 minutes before sun exposure. Reapply every two hours or more frequently if swimming or sweating. It is also recommended to avoid prolonged sun exposure, especially during peak hours when the sun's rays are strongest.

4. References:

- Kaur CD, Saraf S. In vitro sun protection factor determination of herbal oils used in cosmetics. Pharmacognosy Res. 2010;2(1):22-25. doi:10.4103/0974-8490.60586

- Cole C, Gazdik M, DeClercq J. Skin protection against UV light by dietary antioxidants. Food Funct. 2015;6(7):2071-2074. doi:10.1039/c5fo00343e

- Matta MK, Zusterzeel R, Pilli NR, et al. Effect of sunscreen application on plasma concentration of sunscreen active ingredients: a randomized clinical trial. JAMA. 2020;323(3):256-267. doi:10.1001/jama.2019.20747

1. Definition Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer:

Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer is a crosslinked polymer made by combining methyl methacrylate and glycol dimethacrylate. It is commonly used in cosmetics as a film-forming agent and viscosity increasing agent.

2. Use:

Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer is used in cosmetics to create a smooth and even application of products such as foundations, primers, and skincare products. It helps to improve the texture and spreadability of the product on the skin, giving a more uniform and long-lasting finish.

3. Usage Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer:

When using products containing Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but as with any cosmetic ingredient, some individuals may experience sensitivity or allergic reactions. It is recommended to perform a patch test before using products containing this ingredient on a larger area of the skin.

4. References:

- "Safety Assessment of Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer as Used in Cosmetics." Cosmetic Ingredient Review. 2017.

- "Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer." The Dermatology Review. Accessed September 2021.

- "Formulation and Evaluation of Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer-based Topical Gel for the Treatment of Acne." International Journal of Pharmacy and Pharmaceutical Sciences. 2019.

1. Definition Benzophenone-3 (Oxybenzone):

Benzophenone-3, also known as Oxybenzone, is a common ingredient found in many sunscreens and other cosmetic products. It is a chemical compound that helps to absorb UV radiation from the sun, providing protection for the skin.

2. Use:

Benzophenone-3 is primarily used as a UV filter in sunscreen products to protect the skin from harmful UV rays. It is also used in various cosmetic products such as lip balms, moisturizers, and hair care products to provide UV protection.

3. Usage Benzophenone-3 (Oxybenzone):

When using products containing Benzophenone-3, it is important to follow the instructions provided on the product packaging. Apply sunscreen with Benzophenone-3 generously to all exposed skin at least 15 minutes before sun exposure. Reapply every two hours or more frequently if swimming or sweating. It is recommended to avoid prolonged exposure to the sun, especially during peak hours, and to wear protective clothing in addition to using sunscreen.

4. References:

- Tovar-Sánchez, A., Sánchez-Quiles, D., Basterretxea, G., Benedé, J. L., Chisvert, A., Salvador, A., & Moreno-Garrido, I. (2013). Sunscreen products as emerging pollutants to coastal waters. PloS one, 8(6), e65451.

- Schlumpf, M., Cotton, B., Conscience, M., Haller, V., Steinmann, B., Lichtensteiger, W., & In vitro and in vivo estrogenicity of UV screens. Environmental Health Perspectives, 109(3), 239-244.

- Matta, M. K., Florian, J., Zusterzeel, R., Pilli, N. R., Patel, V., Volpe, D. A., ... & Nohynek, G. J. (2019). Effect of sunscreen application on plasma concentration of sunscreen active ingredients: A randomized clinical trial. JAMA, 321(21), 2082-2091.