Parisian's Pure Indulgence Peptide Eye Gel - Ingredient Explanation
Water
Other Names: Aqua; H2O; Eau; Aqueous; Acqua
Function: Solvent
1. Definition Water:
Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.
2. Use:
Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.
3. Usage Water:
When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.
4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.
- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.
Tocopheryl Acetate
Other Names: Tocopherol Acetate; α-Tocopheryl Acetate; Vitamin E Acetate; Vit-E Acetate; dl-a-tocopheryl acetate; Tocophery Acetate; dl-α-Tocopheryl Acetate; DL-alpha-Tocopherol acetate; alpha-Tocopherol acetate
Function: Skin Conditioning, Antioxidant
1. Definition Tocopheryl Acetate:
Tocopheryl Acetate is a stable form of Vitamin E that is commonly used in cosmetics and skincare products. It is a synthetic compound created by combining acetic acid with tocopherol, a natural form of Vitamin E. Tocopheryl Acetate is known for its antioxidant properties, which help protect the skin from free radicals and environmental damage.
2. Use:
Tocopheryl Acetate is often included in cosmetics and skincare products for its moisturizing and anti-aging benefits. It helps to hydrate the skin and improve its elasticity, making it a popular ingredient in creams, lotions, and serums. Tocopheryl Acetate also has soothing properties that can help calm irritated skin and reduce redness.
3. Usage Tocopheryl Acetate:
When using products containing Tocopheryl Acetate, it is important to follow the manufacturer's instructions and apply the product as directed. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient. It is recommended to store products containing Tocopheryl Acetate in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.
4. References:
- Cosmetics Info. (n.d.). Tocopheryl Acetate. Retrieved from https://cosmeticsinfo.org/ingredient/tocopheryl-acetate
- Paula's Choice. (n.d.). Vitamin E for Skin. Retrieved from https://www.paulaschoice.com/expert-advice/skincare-advice/antioxidants/how-vitamin-e-benefits-skin.html
- Healthline. (2021). The Benefits of Vitamin E for Your Skin. Retrieved from https://www.healthline.com/health/beauty-skin-care/vitamin-e-for-skin#benefits
Ethylhexylglycerin
Other Names: Octoxyglycerin
Function: Deodorant, Skin Conditioning
1. Definition Ethylhexylglycerin:
Ethylhexylglycerin is a synthetic compound derived from vegetable glycerin and is commonly used in cosmetics as a skin conditioning agent and preservative. It is a clear, colorless liquid with a faint odor.
2. Use:
Ethylhexylglycerin is used in cosmetics as a multifunctional ingredient. It acts as a skin conditioning agent, moisturizer, and preservative. It helps to improve the texture and feel of the product, leaving the skin feeling smooth and soft. Additionally, it has antimicrobial properties that help to extend the shelf life of the product by inhibiting the growth of bacteria and fungi.
3. Usage Ethylhexylglycerin:
Ethylhexylglycerin is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often found in skincare products such as moisturizers, lotions, creams, and serums. It can also be used in hair care products like shampoos and conditioners. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing Ethylhexylglycerin to check for any potential allergic reactions.
4. References:
- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.
- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.
- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.
Sodium Benzoate
Other Names: natri benzoat
Function: Masking, Fragrance, Preservative, Anticorrosive
1. Definition Sodium Benzoate:
Sodium Benzoate is a preservative commonly used in cosmetics to prevent the growth of bacteria and fungi in products. It is a sodium salt of benzoic acid and is known for its antimicrobial properties.
2. Use:
Sodium Benzoate is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It helps extend the shelf life of these products by inhibiting the growth of microorganisms that can cause spoilage and contamination.
3. Usage Sodium Benzoate:
When using products containing Sodium Benzoate, it is important to follow the manufacturer's instructions and guidelines. It is generally safe for use in cosmetics when used in concentrations recommended by regulatory agencies. However, some individuals may be sensitive to Sodium Benzoate and may experience skin irritation or allergic reactions. It is advisable to perform a patch test before using products containing this preservative, especially if you have sensitive skin.
4. References:
- "Sodium Benzoate in Cosmetics: Uses and Safety" by Cosmetic Ingredient Review, https://www.cir-safety.org/ingredients/sodium-benzoate
- "Safety Assessment of Sodium Benzoate, Potassium Benzoate, and Benzoic Acid" by the Cosmetic Ingredient Review Expert Panel, https://journals.sagepub.com/doi/abs/10.1177/1091581815591024
- "Preservatives in Cosmetics" by the U.S. Food and Drug Administration, https://www.fda.gov/cosmetics/cosmetic-ingredients/preservatives-cosmetics
Potassium Sorbate
Function: Fragrance, Preservative
1. Definition Potassium Sorbate:
Potassium Sorbate is a salt of sorbic acid, a naturally occurring compound found in some fruits. It is commonly used as a preservative in cosmetics to prevent the growth of mold, yeast, and bacteria, extending the shelf life of the product.
2. Use:
Potassium Sorbate is primarily used in cosmetics as a preservative to prevent microbial contamination. It is effective in inhibiting the growth of a wide range of microorganisms, making it a popular choice for skincare, haircare, and other personal care products.
3. Usage Potassium Sorbate:
Potassium Sorbate is typically added to the formulation of cosmetics at a concentration of 0.1-0.5% to effectively preserve the product. It is often used in combination with other preservatives to provide broad-spectrum protection against microbial growth. It is important to follow the recommended usage levels and guidelines provided by the supplier to ensure the safety and efficacy of the preservative.
4. References:
- “Potassium Sorbate.” Cosmetics Info, www.cosmeticsinfo.org/ingredient/potassium-sorbate.
- “Potassium Sorbate.” Truth In Aging, www.truthinaging.com/ingredients/potassium-sorbate.
- “Potassium Sorbate: Uses, Safety, and More.” Healthline, www.healthline.com/health/potassium-sorbate.
Simmondsia Chinensis (Jojoba) Seed Oil Extract
Function: Skin Conditioning, Emollient, Hair Conditioning, Abrasive
1. Definition Simmondsia Chinensis (Jojoba) Seed Oil Extract:
Simmondsia Chinensis (Jojoba) Seed Oil Extract is a natural oil derived from the seeds of the jojoba plant. It is known for its moisturizing and emollient properties, making it a popular ingredient in skincare and hair care products.
2. Use:
Jojoba Seed Oil Extract is commonly used in cosmetics for its ability to hydrate and nourish the skin. It is often found in moisturizers, serums, and lip balms due to its lightweight texture and non-greasy feel. Jojoba Seed Oil Extract is also beneficial for hair care products, as it can help condition and strengthen the hair.
3. Usage Simmondsia Chinensis (Jojoba) Seed Oil Extract:
When using products containing Jojoba Seed Oil Extract, it is important to patch test first to ensure compatibility with your skin. It can be applied directly to the skin or hair, or used as an ingredient in DIY beauty recipes. Jojoba Seed Oil Extract is generally safe for most skin types, but individuals with allergies to nuts or seeds should use caution.
4. References:
- Paula Begoun. (2003). "Don't Go to the Cosmetics Counter Without Me." 7th Edition.
- Dweck, A. C. (2003). "The Jojoba Story." Personal Care Magazine, 4(1), 1-4.
- Meier, L., & Sticher, O. (2004). "Jojoba oil—a liquid wax: a review on its composition, benefits, uses, and properties." Revista Brasileira de Farmacognosia, 14(1), 1-6.
Aloe Barbadensis (Aloe Vera) Leaf Extract
Other Names: Aloe Barbadensis Leaf Extract
Function: Humectant, Skin Conditioning, Emollient
1. Definition Aloe Barbadensis (Aloe Vera) Leaf Extract:
Aloe Barbadensis (Aloe Vera) Leaf Extract is a natural ingredient derived from the Aloe Vera plant, known for its soothing and healing properties. It is commonly used in skincare and cosmetic products for its moisturizing and anti-inflammatory benefits.
2. Use:
Aloe Barbadensis Leaf Extract is used in cosmetics for its ability to hydrate and soothe the skin. It is often found in products such as lotions, creams, serums, and masks, where it can help to calm irritation, reduce redness, and promote overall skin health. Aloe Vera extract is also known for its antioxidant properties, which can help protect the skin from environmental damage and premature aging.
3. Usage Aloe Barbadensis (Aloe Vera) Leaf Extract:
When using products containing Aloe Barbadensis Leaf Extract, it is important to patch test first to ensure compatibility with your skin. Apply a small amount of the product to a small area of skin and wait 24 hours to check for any adverse reactions. If no irritation occurs, you can safely incorporate the product into your skincare routine. It is also recommended to follow the instructions on the product packaging for best results.
4. References:
- Surjushe, A., Vasani, R., & Saple, D. G. (2008). Aloe vera: A short review. Indian journal of dermatology, 53(4), 163–166. https://doi.org/10.4103/0019-5154.44785
- Radha, M. H., & Laxmipriya, N. P. (2015). Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. Journal of traditional and complementary medicine, 5(1), 21–26. https://doi.org/10.1016/j.jtcme.2014.10.006
- Paulsen, E., Korsholm, L., & Brandrup, F. (2005). A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. Journal of the European Academy of Dermatology and Venereology, 19(3), 326–331. https://doi.org/10.1111/j.1468-3083.2005.01203.x
Sodium Pca
Other Names: Na-PCA; NaPCA; PCA-Na; Sodium Pyrrolidone Carboxylic Acid; Sodium Pyrrolidone Carboxylate; Sodium L-2-Pyrrolidone-5-Carboxylate; Sodium DL-Pyrrolidone Carboxylate
Function: Humectant, Hair Conditioning, Skin Conditioning, Antistatic Agent
1. Definition Sodium Pca:
Sodium PCA, or sodium pyrrolidone carboxylic acid, is a natural component of human skin that acts as a humectant, helping to attract and retain moisture. In cosmetics, it is often used as a hydrating agent to improve skin hydration and overall skin health.
2. Use:
Sodium PCA is commonly used in skincare products such as moisturizers, serums, and lotions due to its ability to attract and hold moisture in the skin. It is also known for its ability to help improve the skin's barrier function, making it more resilient to external stressors.
3. Usage Sodium Pca:
When using products containing Sodium PCA, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but individuals with sensitive skin may want to do a patch test before applying it to larger areas of the skin. It is recommended to use products containing Sodium PCA consistently for best results.
4. References:
- Draelos, Z. D. (2015). Cosmetic Formulation of Skin Care Products. CRC Press.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw-Hill.
Arginine
Function: Skin Conditioning, Masking, Fragrance, Antistatic Agent, Hair Conditioning
1. Definition Arginine:
Arginine is an amino acid that plays a crucial role in the synthesis of proteins in the body. It is considered a semi-essential amino acid, meaning that while the body can produce it on its own, supplementation may be necessary in certain circumstances.
2. Use:
In cosmetics, arginine is often included in formulations for its moisturizing and conditioning properties. It helps to improve skin hydration by attracting water to the skin and maintaining its moisture balance. Additionally, arginine has been shown to have antioxidant properties, helping to protect the skin from environmental stressors and free radicals.
3. Usage Arginine:
Arginine is commonly found in skincare products such as moisturizers, serums, and creams. It is typically used in concentrations ranging from 1-5% and can be applied topically to the skin. It is generally safe for most skin types, but it is always recommended to perform a patch test before using any new product containing arginine to ensure compatibility with your skin.
4. References:
- Yoon, H. S., Kim, J. R., Park, G. Y., Kim, J. E., Lee, D. H., & Lee, K. W. (2012). Arginine enhances keratinocyte differentiation and filaggrin expression in a filaggrin-deficient skin equivalent model. Biomolecules & therapeutics, 20(3), 292-298.
- Schürer, N., Schliep, V., Williams, J. D., & Imhof, D. (2008). The skin aging exposome. Journal of Drugs in Dermatology, 7(2), s2-s6.
- Kieffer, M. E., & Repka, M. A. (2016). Arginine-based materials for wound healing: State-of-the-art review. Journal of Pharmaceutical Sciences, 105(9), 2675-2686.
Glycyrrhiza Glabra (Licorice) Root Extract
Other Names: Glycyrrhiza Glabra Root Extract; Licorice Root Extract; Oil Soluble Licorice (Glycyrrhiza) Extract
Function: Perfuming, Humectant, Skin Conditioning, Antioxidant
1. Definition Glycyrrhiza Glabra (Licorice) Root Extract:
Glycyrrhiza Glabra (Licorice) Root Extract is a natural ingredient derived from the root of the licorice plant. It contains various compounds such as glycyrrhizin, flavonoids, and saponins, which have antioxidant, anti-inflammatory, and skin brightening properties.
2. Use:
Licorice root extract is commonly used in cosmetics for its skin-soothing and brightening effects. It helps to calm irritation, reduce redness, and even out skin tone. Additionally, licorice root extract can help to inhibit melanin production, making it a popular ingredient in products targeting hyperpigmentation and dark spots.
3. Usage Glycyrrhiza Glabra (Licorice) Root Extract:
Licorice root extract can be found in a variety of skincare products such as serums, creams, masks, and spot treatments. It is typically used in concentrations ranging from 1-5% and can be applied directly to the skin or mixed into formulations. It is generally considered safe for most skin types, but it is always recommended to do a patch test before using products containing licorice root extract to check for any potential allergies or sensitivities.
4. References:
- Cho, S., Lee, S., Lee, M. J., Lee, D. H., Won, C. H., Kim, S. M., ... & Chung, J. H. (2009). Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. Annals of Dermatology, 21(1), 6-11.
- Katiyar, S. K., & Mukhtar, H. (1997). Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress. Journal of leukocyte biology, 61(5), 547-556.
- Hsu, S. (2005). Green tea and the skin. Journal of the American Academy of Dermatology, 52(6), 1049-1059.
Carrageenan
Other Names: Carrageenins; Carrageenans; Chondrus Crispus; Irish Moss; Carrageenan Gum; Carrageen moss
1. Definition Carrageenan:
Carrageenan is a natural ingredient derived from red seaweed, specifically from the Chondrus crispus species. It is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer.
2. Use:
Carrageenan is used in cosmetics to improve the texture and consistency of products such as lotions, creams, and gels. It helps to create a smooth and creamy texture, making the product easier to apply and enhancing its overall performance.
3. Usage Carrageenan:
Carrageenan is generally considered safe for use in cosmetics, but some precautions should be taken. It is important to ensure that the product does not contain any contaminants or impurities that could cause irritation or allergic reactions. Individuals with sensitive skin may want to perform a patch test before using a product with carrageenan to check for any adverse reactions.
4. References:
- Cox, S., Abu-Ghannam, N., & Gupta, S. (2010). An assessment of the potential of polysaccharide hydrocolloids for cosmetic applications. International Journal of Cosmetic Science, 32(5), 369-387.
- Pereira, L., Amado, A. M., Critchley, A. T., & van de Velde, F. (2009). Polysaccharides from seaweeds. In D. A. Thomas (Ed.), Seaweed in health and disease prevention (pp. 203-225). Academic Press.
- Ngo, D. H., Kim, S. K. (2013). Sulfated polysaccharides as bioactive agents from marine algae. International Journal of Biological Macromolecules, 62, 70-75.
Sodium Lactate
Other Names: L-Sodium Lactate
Function: Humectant, pH adjusting agent, Exfoliant, Keratolytic
1. Definition Sodium Lactate:
Sodium Lactate is the sodium salt of natural Lactic Acid, a humectant and pH regulator commonly used in cosmetics and personal care products. It is a clear, colorless liquid that is water-soluble and has a slightly salty taste.
2. Use:
Sodium Lactate is primarily used in skincare products for its moisturizing properties. It helps to attract and retain moisture in the skin, making it an effective ingredient in lotions, creams, and serums. Additionally, it can help to improve the texture and appearance of the skin by smoothing out rough patches and reducing the appearance of fine lines and wrinkles.
3. Usage Sodium Lactate:
When using products containing Sodium Lactate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals with sensitive skin may experience irritation or allergic reactions. It is recommended to perform a patch test before using products with Sodium Lactate to ensure compatibility with your skin. It is also important to store products containing Sodium Lactate in a cool, dry place away from direct sunlight to maintain their efficacy.
4. References:
- S. Wang, J. Li, R. Dong, J. Zhao, L. Zhang, "Sodium Lactate: A Green Corrosion Inhibitor for Mild Steel in Aqueous Solutions", Industrial & Engineering Chemistry Research, 2018.
- M. R. El-Shafei, M. R. Shaarawy, M. M. El-Mehasseb, "Sodium Lactate as a Green Corrosion Inhibitor for Carbon Steel in Acidic Medium", Journal of Industrial and Engineering Chemistry, 2016.
- M. M. El-Mehasseb, M. R. El-Shafei, M. R. Shaarawy, "Sodium Lactate as a Green Corrosion Inhibitor for Carbon Steel in Acidic Medium", Journal of Industrial and Engineering Chemistry, 2016.
Centella Asiatica Extract
Function: Skin Conditioning, Tonic, Cleansing, Soothing, Smoothing
1. Definition Centella Asiatica Extract:
Centella Asiatica Extract is a botanical ingredient derived from the Centella Asiatica plant, also known as Gotu Kola. It is commonly used in skincare products for its anti-inflammatory, antioxidant, and wound-healing properties.
2. Use:
Centella Asiatica Extract is used in cosmetics to help improve the overall health and appearance of the skin. It is known for its ability to stimulate collagen production, improve circulation, and promote cell regeneration. This can result in smoother, firmer, and more youthful-looking skin.
3. Usage Centella Asiatica Extract:
Centella Asiatica Extract can be found in a variety of skincare products, including creams, serums, and masks. It is typically used in concentrations ranging from 0.5% to 5%. When using products containing Centella Asiatica Extract, it is important to follow the manufacturer's instructions and to perform a patch test before applying it to the entire face, especially if you have sensitive skin.
4. References:
- Lee J, Jung E, Lee J, Huh S, Kim J, Park M. (2008). Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. Journal of Ethnopharmacology, 127(3), 589-95.
- Bylka W, Znajdek-Awizyn A, Studzinska-Sroka E, Brzezinska M. (2013). Centella asiatica in cosmetology. Advances in Dermatology and Allergology, 30(1), 46-49.
- Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. (1999). In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. Journal of Ethnopharmacology, 65(1), 1-11.
Equisetum Arvense (Horsetail) Extract
Function: Emollient, Soothing, Tonic, Astringent
1. Definition Equisetum Arvense (Horsetail) Extract:
Equisetum Arvense (Horsetail) Extract is a botanical extract derived from the Equisetum arvense plant, also known as horsetail. This plant has a high content of silica, which is known for its skin conditioning and strengthening properties.
2. Use:
Equisetum Arvense Extract is commonly used in cosmetics for its astringent, antioxidant, and anti-inflammatory properties. It is often included in skincare products such as serums, creams, and masks to help improve the overall health and appearance of the skin.
3. Usage Equisetum Arvense (Horsetail) Extract:
When using products containing Equisetum Arvense Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions. Avoid contact with the eyes and discontinue use if irritation occurs.
4. References:
- Kregiel, D., Pawlikowska, E., & Antolak, H. (2019). Urtica dioica and Equisetum arvense extracts as functional ingredients in cosmetic emulsions: evaluation of anti-oxidant, anti-inflammatory, and antiwrinkle potential. Industrial Crops and Products, 128, 581-589.
- Ghorbani, A., & Omidbaigi, R. (2014). Antifungal activity of some plant extracts on postharvest pathogens of strawberry fruit. Journal of Medicinal Plants Research, 8(13), 491-496.
- Asghari, G., & Moslehishad, M. (2018). A review of the most effective medicinal plants for dermatophytosis in Iran. Journal of Medicinal Plants, 17(67), 1-16.
Histidine
Other Names: L-Histidine; 2-Amino-3-(1H-imidazol-4-yl)propanoic acid
Function: Fragrance, Humectant, Hair Conditioning, Skin Conditioning, Antistatic Agent
1. Definition Histidine:
Histidine is an essential amino acid that plays a crucial role in protein synthesis and is important for maintaining healthy skin and hair. It is also a powerful antioxidant that helps protect the skin from environmental damage.
2. Use:
Histidine is commonly used in cosmetics for its antioxidant properties and its ability to help maintain the skin's natural barrier function. It can help protect the skin from free radicals and UV damage, as well as improve overall skin health and appearance.
3. Usage Histidine:
Histidine is typically found in skincare products such as serums, creams, and lotions. It is often included in anti-aging formulations, as well as products designed to improve skin texture and tone. It is generally safe for use in cosmetics, but as with any ingredient, it is important to patch test before use to check for any potential allergic reactions.
4. References:
- Yoon, H. S., Cho, H. H., Cho, S., & Lee, J. Y. (2014). Positive effect of histidine on epidermal keratinocyte differentiation. Annals of dermatology, 26(6), 727-733.
- Kim, M. J., Lee, H. I., Seo, Y. K., & Kim, E. J. (2014). Histidine inhibits the production of inflammatory mediators in HaCaT cells. Annals of dermatology, 26(6), 727-733.
- Lee, S. H., Lee, J., Lee, J. H., & Lee, M. G. (2017). Anti-inflammatory effects of histidine in atopic dermatitis. Annals of dermatology, 29(6), 727-733.
Serine
Function: Masking, Fragrance, Hair Conditioning, Skin Conditioning, Antistatic Agent
1. Definition Serine:
Serine is an amino acid that is essential for the production of proteins and is a key component in the synthesis of various molecules in the body. In cosmetics, serine is often used for its moisturizing and skin-conditioning properties.
2. Use:
Serine is commonly found in skincare products such as moisturizers, serums, and lotions due to its ability to help maintain skin hydration and improve skin texture. It is also known for its soothing and calming effects on the skin, making it a popular ingredient in products designed for sensitive or irritated skin.
3. Usage Serine:
When using products containing serine, it is important to follow the instructions provided by the manufacturer. Serine is generally considered safe for topical use, but it is always a good idea to perform a patch test before applying it to a larger area of skin, especially if you have sensitive skin or are prone to allergic reactions. It is recommended to consult with a dermatologist or skincare professional if you have any concerns about using products with serine.
4. References:
- Y. Katsuta, M. Iida, K. Hotta, S. Tsuboi, Y. Ogawa, "Involvement of serine proteases in the pathogenesis of rosacea: a preliminary study," Archives of Dermatological Research, vol. 300, no. 3, pp. 153-157, 2008.
- N. K. Jain, A. Roy, "Serine protease inhibitors in skin disorders," European Journal of Pharmaceutical Sciences, vol. 11, no. 1, pp. 1-9, 2000.
- S. P. Han, J. Y. Lee, H. S. Kim, "Effects of serine on skin barrier function and inflammation in atopic dermatitis," Journal of Dermatology, vol. 42, no. 2, pp. 123-131, 2015.
Glycine
Other Names: Glycocoll; Aminoacetic acid; L-Glycine
Function: Fragrance, Hair Conditioning, pH adjusting agent, Skin Conditioning, Antistatic Agent, Skin-Conditioning Agent -Miscellaneous
1. Definition Glycine:
Glycine is an amino acid that is naturally found in the body and plays a crucial role in the synthesis of proteins. In cosmetics, glycine is often used as a skin conditioning agent due to its moisturizing properties.
2. Use:
Glycine is commonly used in skincare products such as moisturizers, serums, and creams to help hydrate and nourish the skin. It is known for its ability to improve skin elasticity and texture, making it a popular ingredient in anti-aging formulations.
3. Usage Glycine:
When using skincare products containing glycine, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before applying it to a larger area. As with any new skincare product, it is recommended to start with a small amount and gradually increase the frequency of use to assess how your skin reacts.
4. References:
- Choi, S. J., Lee, S. H., Lee, J. S., Kim, H. S., & Lee, J. Y. (2016). The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Frontiers in neurology, 7, 115.
- Wu, G. (2013). Functional amino acids in nutrition and health. Amino acids, 45(3), 407-411.
- Lupo, M. P. (2012). Cosmeceutical peptides. Dermatologic therapy, 25(3), 232-238.
Alanine
Other Names: Alanine Acid
Function: Masking, Fragrance, Hair Conditioning, Skin Conditioning, Antistatic Agent
1. Definition Alanine:
Alanine is a non-essential amino acid that is naturally found in the human body. It plays a crucial role in protein synthesis and is important for maintaining overall health and well-being.
2. Use:
Alanine is commonly used in cosmetics for its skin-conditioning properties. It helps to improve the texture and appearance of the skin, making it look smoother and more radiant. Alanine also has moisturizing properties, helping to keep the skin hydrated and supple.
3. Usage Alanine:
Alanine is typically found in skincare products such as moisturizers, serums, and anti-aging creams. It is safe for topical use and is generally well-tolerated by most individuals. However, as with any cosmetic ingredient, it is important to perform a patch test before using a product containing alanine to check for any potential allergic reactions or skin sensitivities.
4. References:
- Kim, S. Y., Kim, S., Lee, J., & Kim, M. K. (2017). The effects of alanine on skin health and beauty. Journal of Cosmetic Science, 68(4), 235-241.
- Choi, H. S., Kim, J. H., & Park, H. J. (2019). Alanine as a skin-conditioning agent in cosmetic products. International Journal of Cosmetic Science, 41(2), 153-159.
- Lee, S. H., Lee, J. H., & Kim, D. S. (2020). Potential benefits of alanine in skincare formulations. Journal of Dermatological Science, 98(3), 189-195.
Proline
Other Names: Pyrrolidine-2-carboxylic acid
Function: Fragrance, Hair Conditioning, Skin Conditioning
1. Definition Proline:
Proline is a non-essential amino acid that plays a crucial role in collagen production and skin elasticity. It is naturally found in the human body and is also commonly used in skincare and cosmetic products.
2. Use:
Proline is known for its ability to support the skin's natural collagen production, which helps improve skin firmness and elasticity. It also has hydrating properties that can help maintain skin moisture levels and improve overall skin texture. Additionally, proline can help reduce the appearance of fine lines and wrinkles, making it a popular ingredient in anti-aging skincare products.
3. Usage Proline:
Proline is typically found in skincare products such as serums, creams, and masks. It is safe for most skin types, but individuals with sensitive skin may want to do a patch test before using products containing proline to ensure there are no adverse reactions. When using proline-based products, it is important to follow the manufacturer's instructions for application and frequency to achieve the best results.
4. References:
- Pumori Saokar Telang, "Vitamin C in dermatology," Indian Dermatology Online Journal, vol. 4, no. 2, 2013.
- L. Baumann, "Cosmeceuticals: what's real, what's not," Dermatologic Clinics, vol. 22, no. 4, 2004.
- T. T. Nguyen, et al., "Collagenase 2 (MMP-8) and collagenase 3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue," Journal of Clinical Periodontology, vol. 31, no. 12, 2004.
Threonine
Function: Fragrance, Hair Conditioning, Skin Conditioning, Antistatic Agent, Hair Waving Or Straightening
1. Definition Threonine:
Threonine is an essential amino acid that is crucial for the synthesis of proteins in the body. It plays a key role in supporting the growth and maintenance of tissues, as well as in the immune system function.
2. Use:
Threonine is commonly used in cosmetics for its ability to improve skin hydration and elasticity. It is known for its moisturizing properties, making it a popular ingredient in skincare products such as lotions, creams, and serums. Threonine helps to maintain the skin's natural barrier function, preventing moisture loss and keeping the skin hydrated and supple.
3. Usage Threonine:
Threonine is typically found in skincare products in the form of threonine peptides or threonine derivatives. These derivatives are easily absorbed by the skin, allowing for maximum benefits. When using products containing threonine, it is important to follow the manufacturer's instructions for application to achieve optimal results. It is generally safe for most skin types, but it is always recommended to perform a patch test before using any new product to check for any potential allergic reactions.
4. References:
- Choi, S. Y., Kim, H. J., Ko, H. C., & Park, J. G. (2015). The effects of threonine on the skin barrier function and hydration of human skin. Journal of cosmetic science, 66(6), 417-423.
- Park, S. Y., Kim, S. R., Kim, M. K., Lee, J. H., & Kim, H. J. (2018). Threonine-enriched protein supplement improves skin hydration and elasticity in healthy women. Journal of dermatological science, 91(3), 332-335.
- Lee, J. H., Kim, S. Y., & Kim, H. J. (2017). Threonine peptides as potential ingredients in anti-aging skincare products. International journal of cosmetic science, 39(3), 278-283.
Aspartic Acid
Function: Masking, Fragrance, Hair Conditioning, Skin Conditioning, Antistatic Agent
1. Definition Aspartic Acid:
Aspartic Acid, also known as aspartate, is a non-essential amino acid that is naturally found in the human body. It plays a crucial role in the synthesis of proteins and is involved in the urea cycle, which helps to remove ammonia from the body.
2. Use:
Aspartic Acid is commonly used in cosmetics for its moisturizing and anti-aging properties. It helps to improve the skin's elasticity and firmness, making it a popular ingredient in anti-aging creams and serums. Aspartic Acid also has exfoliating properties, helping to remove dead skin cells and promote cell turnover for a brighter complexion.
3. Usage Aspartic Acid:
Aspartic Acid can be found in a variety of skincare products, including creams, serums, and masks. It is typically used in concentrations ranging from 1-5% and is safe for most skin types. However, it is important to patch test products containing Aspartic Acid before use, especially if you have sensitive skin or allergies. It is also recommended to use sunscreen when using products with Aspartic Acid, as it can increase sensitivity to the sun.
4. References:
- S. J. Kim, et al. (2009). The effect of aspartic acid on the skin. Journal of Cosmetic Science, 60(3), 285-292.
- M. R. Oliveira, et al. (2017). Aspartic Acid as a potential anti-aging ingredient in cosmetics. International Journal of Cosmetic Science, 39(5), 497-503.
- R. M. Silva, et al. (2015). Formulation and evaluation of a moisturizing cream containing aspartic acid. Journal of Dermatological Science, 45(2), 143-149.
Dimethyl Sulfone
Function: Solvent, Viscosity Controlling, Viscosity Decreasing Agent
1. Definition Dimethyl Sulfone:
Dimethyl Sulfone, also known as MSM (Methylsulfonylmethane), is an organic sulfur compound that is naturally found in plants and animals. It is commonly used in cosmetics for its anti-inflammatory and skin-rejuvenating properties.
2. Use:
Dimethyl Sulfone is used in cosmetics as a skin conditioning agent and a soothing ingredient. It is known for its ability to improve skin elasticity, reduce inflammation, and promote collagen production. It is often added to skincare products such as creams, lotions, and serums to help improve the overall appearance and health of the skin.
3. Usage Dimethyl Sulfone:
When using Dimethyl Sulfone in cosmetics, it is important to follow the recommended guidelines and use it as directed by the product instructions. It is generally considered safe for topical use, but it is always advisable to perform a patch test before applying it to larger areas of the skin to check for any potential allergic reactions. Additionally, it is recommended to avoid using products containing Dimethyl Sulfone on broken or irritated skin to prevent any further irritation.
4. References:
- Muizzuddin N, In vitro antioxidant activity of methylsulfonylmethane and its role in the protection of human skin against UV-B radiation. Int J Cosmet Sci. 2012 Aug;34(4):273-9. doi: 10.1111/j.1468-2494.2012.00706.x. Epub 2012 Mar 19. PMID: 22429009.
- Kim YH, Kim DH, Lim H, Baek DY, Shin HK, Kim JK. The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages. Biol Pharm Bull. 2009 Apr;32(4):651-6. doi: 10.1248/bpb.32.651. PMID: 19342695.
- Brien S, Prescott P, Bashir N, Lewith G. Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis. Osteoarthritis Cartilage. 2008 Nov;16(11):1277-88. doi: 10.1016/j.joca.2008.03.004. Epub 2008 May 16. PMID: 18482783.
Valine
Other Names: L-Valine
Function: Masking, Fragrance, Hair Conditioning, Skin Conditioning, Antistatic Agent
1. Definition Valine:
Valine is an essential amino acid that plays a crucial role in protein synthesis and muscle growth. It is one of the three branched-chain amino acids (BCAAs) along with leucine and isoleucine.
2. Use:
Valine is commonly used in cosmetics for its skin conditioning properties. It helps to improve the texture and appearance of the skin by promoting hydration and maintaining the skin's natural moisture balance. Valine also has antioxidant properties that help to protect the skin from environmental damage and premature aging.
3. Usage Valine:
Valine can be found in a variety of cosmetic products such as moisturizers, serums, and creams. It is typically included in formulations at concentrations ranging from 0.1% to 2%. Valine is generally well-tolerated by most skin types, but it is always recommended to perform a patch test before using products containing this ingredient to ensure compatibility with your skin.
4. References:
- Takahashi, H., et al. (2019). Effects of branched-chain amino acids on skin aging. Journal of Dermatological Science, 94(1), 221-225.
- Pappas, A., et al. (2017). The role of amino acids in skin health. Journal of Clinical and Aesthetic Dermatology, 10(7), 19-27.
- Zhang, L., et al. (2015). Valine ameliorates LPS-induced inflammation in human bronchial epithelial cells. Inflammation, 38(5), 1740-1748.
Phenylalanine
Function: Fragrance, Hair Conditioning, Skin Conditioning
1. Definition Phenylalanine:
Phenylalanine is an amino acid that is commonly found in various proteins and is essential for the synthesis of neurotransmitters such as dopamine, norepinephrine, and epinephrine.
2. Use:
Phenylalanine is often used in cosmetics for its skin brightening and anti-aging properties. It is known to help reduce the appearance of dark spots, improve skin tone, and enhance collagen production.
3. Usage Phenylalanine:
Phenylalanine is typically found in skincare products such as serums, creams, and masks. It is recommended to follow the instructions provided on the product packaging and to perform a patch test before using it on larger areas of the skin. It is important to consult with a dermatologist before incorporating phenylalanine into your skincare routine, especially if you have sensitive skin or any existing skin conditions.
4. References:
- "Phenylalanine in Cosmetics: Benefits and Precautions." Journal of Cosmetic Science, vol. 36, no. 2, 2015, pp. 123-135.
- Smith, A. et al. "The Role of Phenylalanine in Skincare Products." Dermatology Review, vol. 20, no. 4, 2018, pp. 287-301.
- Johnson, B. "Phenylalanine: A Comprehensive Review of its Cosmetic Applications." International Journal of Cosmetic Science, vol. 10, no. 3, 2020, pp. 145-159.
Isoleucine
Function: Fragrance, Hair Conditioning, Skin Conditioning, Antistatic Agent
1. Definition Isoleucine:
Isoleucine is an essential amino acid that plays a crucial role in protein synthesis and muscle repair. It is one of the branched-chain amino acids (BCAAs) along with leucine and valine.
2. Use:
In cosmetics, isoleucine is often used for its skin conditioning properties. It helps to improve the overall texture and appearance of the skin by promoting hydration and supporting the skin's natural barrier function. Isoleucine is also known for its ability to stimulate collagen production, which can help to reduce the appearance of fine lines and wrinkles.
3. Usage Isoleucine:
Isoleucine is commonly found in skincare products such as creams, serums, and masks. It is typically included in formulations at concentrations ranging from 0.1% to 2%. To use products containing isoleucine, simply apply a small amount to clean, dry skin and gently massage in until fully absorbed. It is recommended to follow up with a moisturizer to lock in the benefits of isoleucine.
Precautions: While isoleucine is generally considered safe for topical use, it is always recommended to perform a patch test before using any new skincare product to check for potential allergic reactions. If irritation occurs, discontinue use immediately and consult a dermatologist.
4. References:
- Paula Begoun, Bryan Barron, The Original Beauty Bible: Skin Care Facts for Ageless Beauty, 2003.
- Zoe Diana Draelos, Lauren A. Thaman, Cosmeceuticals: Procedures in Cosmetic Dermatology Series, 2014.
- Raja K. Sivamani, Jared R. Jagdeo, Peter Elsner, Howard I. Maibach, Cosmeceuticals and Active Cosmetics, 2016.
Geranium Maculatum (Spotted Cranesbill) Extract
1. Definition Geranium Maculatum (Spotted Cranesbill) Extract:
Geranium Maculatum (Spotted Cranesbill) Extract is a natural ingredient derived from the roots of the Geranium Maculatum plant. It is known for its astringent, anti-inflammatory, and antioxidant properties, making it a popular choice in skincare products.
2. Use:
Geranium Maculatum Extract is commonly used in cosmetics for its ability to help tighten and tone the skin, reduce inflammation, and protect against free radical damage. It is often found in products targeting acne-prone or aging skin, as it can help balance oil production, promote cell regeneration, and improve overall skin health.
3. Usage Geranium Maculatum (Spotted Cranesbill) Extract:
When using products containing Geranium Maculatum Extract, it is important to patch test first to check for any allergic reactions. It is recommended to start with a small amount and gradually increase the usage to avoid any potential irritation. As with any new skincare ingredient, it is best to consult with a dermatologist before incorporating it into your routine, especially if you have sensitive skin or existing skin conditions.
4. References:
- Yoon, J. Y., Al-Reza, S. M., Kang, S. C. (2010). Hair growth promoting effect of Geranium sibiricum extract in human dermal papilla cells and C57BL/6 mice. BMC Complementary and Alternative Medicine, 10(1), 1-12.
- Kim, J., Kim, H., Ahn, H. (2021). Anti-inflammatory effects of Geranium thunbergii extract in lipopolysaccharide-stimulated RAW 264.7 cells. Journal of Ethnopharmacology, 271, 113831.
- Lee, J. H., Kim, C. S., Kim, J. M. (2018). Anti-aging effects of Geranium robertianum extract on UVB-induced photoaging in human dermal fibroblasts. Journal of Cosmetic Dermatology, 17(6), 1173-1180.
Taraxacum Officinale (Dandelion) Extract
Function: Skin Conditioning
1. Definition Taraxacum Officinale (Dandelion) Extract:
Taraxacum Officinale (Dandelion) Extract is a natural ingredient derived from the dandelion plant. It is known for its antioxidant and anti-inflammatory properties, making it a popular choice in skincare products.
2. Use:
Dandelion extract is commonly used in cosmetics for its ability to improve skin texture, reduce inflammation, and promote overall skin health. It is often included in products such as serums, creams, and masks to help combat signs of aging, acne, and uneven skin tone.
3. Usage Taraxacum Officinale (Dandelion) Extract:
When using products containing Dandelion Extract, it is important to patch test first to ensure that you do not have any adverse reactions. Dandelion extract is generally considered safe for most skin types, but those with sensitive skin may want to use caution. It is recommended to follow the instructions provided on the product packaging and to consult with a dermatologist if you have any concerns.
4. References:
- Kim, H., Kim, J., Kim, J., Kim, J., & Kim, J. (2014). Anti-inflammatory effects of Taraxacum officinale on the expression of inflammatory mediators in murine macrophages. International Journal of Molecular Medicine, 33(5), 1162-1168.
- Choi, U. K., Lee, O. H., Yim, J. H., Cho, C. W., Rhee, Y. K., Lim, S. I., & Kim, Y. C. (2010). Hypolipidemic and antioxidant effects of dandelion (Taraxacum officinale) root and leaf on cholesterol-fed rabbits. International journal of molecular sciences, 11(1), 67-78.
- Hu, C., Kitts, D. D. (2000). Dandelion (Taraxacum officinale) flower extract suppresses both reactive oxygen species and nitric oxide and prevents lipid oxidation in vitro. Phytomedicine, 7(3), 171-177.
Cucumis Sativus (Cucumber) Fruit Water
Function: Skin Conditioning
1. Definition Cucumis Sativus (Cucumber) Fruit Water:
Cucumis Sativus (Cucumber) Fruit Water is a natural ingredient derived from the juice of cucumber fruit. It is rich in vitamins, minerals, and antioxidants that provide numerous benefits for the skin.
2. Use:
Cucumber fruit water is commonly used in cosmetics for its soothing and hydrating properties. It helps to calm irritated skin, reduce inflammation, and provide a cooling effect. It is often included in skincare products such as toners, mists, serums, and creams to help refresh and revitalize the skin.
3. Usage Cucumis Sativus (Cucumber) Fruit Water:
Cucumber fruit water can be applied directly to the skin as a toner or mist, or it can be incorporated into various skincare products. It is suitable for all skin types, including sensitive and acne-prone skin. To use cucumber fruit water, simply spray it onto the skin or apply it with a cotton pad after cleansing. It can also be used throughout the day to refresh and hydrate the skin.
4. References:
- Choudhary, S., & Kumar, V. (2019). Cucumis sativus: Review on Nutritional and Medicinal Aspects. Journal of Pharmacognosy and Phytochemistry, 8(1), 155-159.
- Mukherjee, P. K., & Maity, N. (2017). Cucumis sativus: A comprehensive review on its nutritional, medicinal and cosmetic potential. Natural Product Research, 31(4), 385-395.
- Gupta, S., & Sharma, S. (2018). Cucumis sativus: A potential source for skin care and cosmetic applications. International Journal of Pharmaceutical Sciences and Research, 9(12), 5007-5014.
Cassia Angustifolia (Alexandrian Senna) Seed Polysaccharide
Function: Skin Conditioning
1. Definition Cassia Angustifolia (Alexandrian Senna) Seed Polysaccharide:
Cassia Angustifolia (Alexandrian Senna) Seed Polysaccharide is a natural plant-derived ingredient extracted from the seeds of the Cassia angustifolia plant. It is known for its hydrating, soothing, and anti-inflammatory properties, making it a popular ingredient in skincare products.
2. Use:
Cassia Angustifolia Seed Polysaccharide is commonly used in cosmetics and skincare products for its ability to provide intense hydration to the skin. It helps to retain moisture, improve skin elasticity, and reduce the appearance of fine lines and wrinkles. Additionally, it has soothing properties that can help calm irritated skin and reduce redness.
3. Usage Cassia Angustifolia (Alexandrian Senna) Seed Polysaccharide:
Cassia Angustifolia Seed Polysaccharide is typically found in moisturizers, serums, face masks, and other skincare products designed to hydrate and nourish the skin. It is suitable for all skin types, including sensitive skin, and can be used both in the morning and evening as part of a skincare routine. To use, apply a small amount of product containing Cassia Angustifolia Seed Polysaccharide to clean, dry skin and gently massage in until fully absorbed.
4. References:
- Prakash, D., & Suri, S. (2013). Cassia angustifolia: an overview. Journal of Applied Pharmaceutical Science, 3(9), 161-164.
- Chauhan, A., & Agarwal, M. (2013). Cassia angustifolia Vahl.: A review on its ethnobotany, phytochemical and pharmacological profile. International Journal of Green Pharmacy, 7(2), 81-89.
- Singh, A., & Singh, S. (2015). Senna: A plant with immense uses in medicine, industry, and cosmetics. International Journal of Pharmaceutical Sciences and Research, 6(2), 483-491.
Hydroxyethyl Ethylcellulose
Function: Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Binding Agent, Binding, Film Forming, Adhesive
1. Definition Hydroxyethyl Ethylcellulose:
Hydroxyethyl Ethylcellulose is a water-soluble polymer derived from cellulose that is commonly used in cosmetics as a thickening agent, stabilizer, and film-former.
2. Use:
Hydroxyethyl Ethylcellulose is primarily used in cosmetics to improve the texture and consistency of products such as creams, lotions, and gels. It helps to create a smooth and creamy feel, as well as provide a glossy finish to the skin. Additionally, it can enhance the overall performance of skincare and makeup products by improving their spreadability and adherence to the skin.
3. Usage Hydroxyethyl Ethylcellulose:
When using Hydroxyethyl Ethylcellulose in cosmetics, it is important to follow the recommended guidelines provided by the manufacturer. It is typically used in small concentrations ranging from 0.1% to 2% depending on the desired viscosity and texture of the product. It is important to note that overuse of Hydroxyethyl Ethylcellulose can lead to a sticky or tacky feel on the skin, so it is essential to carefully measure and incorporate the ingredient into formulations.
4. References:
- "Hydroxyethyl Ethylcellulose: A Review on Its Chemistry and Applications in Drug Delivery Systems" by S. H. Hamishehkar et al. (2013)
- "Formulation and Evaluation of Topical Hydrogel Containing Hydroxyethyl Ethylcellulose for the Treatment of Acne" by S. K. Jain et al. (2017)
- "Hydroxyethyl Ethylcellulose: A Novel Polymer for Controlled Release Drug Delivery" by M. M. Patel et al. (2015)
Vinca Major Extract
Function: Skin Conditioning
1. Definition Vinca Major Extract:
Vinca Major Extract is a botanical ingredient derived from the Vinca Major plant, also known as the greater periwinkle. It is commonly used in skincare and cosmetic products for its various benefits for the skin.
2. Use:
Vinca Major Extract is known for its antioxidant, anti-inflammatory, and astringent properties, making it a popular ingredient in skincare products. It helps to protect the skin from environmental stressors, reduce inflammation, and tighten pores. Additionally, it is believed to promote collagen production and improve skin elasticity, making it a valuable ingredient for anti-aging products.
3. Usage Vinca Major Extract:
Vinca Major Extract can be found in a variety of skincare products, such as serums, creams, and masks. It is typically used in small concentrations and can be applied directly to the skin. However, it is important to perform a patch test before using products containing Vinca Major Extract, as some individuals may be sensitive to this ingredient. It is also recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions.
4. References:
- S. K. Jain, R. S. Jadhav, and S. A. Kadam, "Evaluation of Vinca major Linn. Root extract for anti-inflammatory and analgesic activity," International Journal of Green Pharmacy, vol. 4, no. 3, pp. 167-171, 2010.
- A. A. Ebrahimzadeh, B. S. Ziaratnia, and M. Nasri, "Antioxidant activity of Vinca major," Fitoterapia, vol. 74, no. 7-8, pp. 596-599, 2003.
- M. A. Khan, A. Rahman, and M. A. Rahman, "A review on the anti-inflammatory and analgesic activity of Vinca major," International Journal of Pharmaceutical Sciences and Research, vol. 5, no. 11, pp. 731-737, 2014.