Peter Thomas Roth Peptide 21 Lift & Firm Moisturizer

1. Definition Glycereth 26:

Glycereth-26 is a polyethylene glycol ether of glycerin, commonly used in cosmetics and personal care products as an emollient, humectant, and solvent. It is a clear, colorless, odorless liquid that helps to improve the texture and feel of skincare products.

2. Use:

Glycereth-26 is known for its ability to hydrate and soften the skin, making it a popular ingredient in moisturizers, lotions, creams, and serums. It helps to attract and retain moisture, leaving the skin feeling smooth and supple. Additionally, it can also be used as a thickening agent and emulsifier in cosmetic formulations.

3. Usage Glycereth 26:

Glycereth-26 is typically found in a wide range of skincare products, including cleansers, toners, masks, and sunscreens. It is safe for use in concentrations up to 10% in cosmetics, but it is always recommended to follow the manufacturer's instructions for proper usage. Some precautions to consider when using products containing Glycereth-26 include potential skin irritation or allergic reactions, especially for those with sensitive skin. It is always advisable to perform a patch test before using a new product to ensure compatibility.

4. References:

- International Journal of Toxicology. (2008). Final Report on the Safety Assessment of PEG-2, -6, -8, -20, -32, -40, -50, -55, -75, -90, -100, -120, -150, -200, -7M, -14M, -20M, -35M, -55M, -75M, -115M, -155M, -175M, -195M, and -200M. 27(S2), 1-82.

- Cosmetics Info. (n.d.). Glycereth-26. Retrieved from https://www.cosmeticsinfo.org/ingredient/glycereth-26

- Personal Care Council. (2019). Safety Assessment of PEG/PPG Esters and Their Ethoxylates as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/resource-center/safety-assessments/

1. Definition Squalane:

Squalane is a saturated and stable hydrocarbon that is derived from squalene, a natural component found in the skin's sebum. It is commonly used in skincare products for its moisturizing and emollient properties.

2. Use:

Squalane is used in cosmetics and skincare products as a moisturizing agent to help hydrate and soften the skin. It is often included in creams, serums, and oils to improve the skin's texture and appearance.

3. Usage Squalane:

Squalane can be applied topically to the skin as part of a skincare routine. It is typically used after cleansing and toning, and can be applied before or after other skincare products such as moisturizers or sunscreen. Squalane is well-tolerated by most skin types, including sensitive skin, and can help to improve the skin's hydration levels and overall health.

Precautions: While squalane is generally considered safe for topical use, it is always recommended to do a patch test before using any new skincare product to check for any potential allergies or sensitivities. Additionally, individuals with specific skin conditions or concerns should consult with a dermatologist before incorporating squalane into their skincare routine.

4. References:

- Baumann, L. (2005). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill.

- Draelos, Z. D. (2015). Cosmeceuticals. Philadelphia: Saunders.

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327-348.

1. Definition Butylene Glycol:

Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.

2. Use:

Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.

3. Usage Butylene Glycol:

Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

1. Definition Behenyl Alcohol:

Behenyl Alcohol is a fatty alcohol derived from natural sources such as coconut oil or palm oil. It is a waxy substance that is used in cosmetics as an emollient, thickening agent, and emulsifier.

2. Use:

Behenyl Alcohol is commonly used in skincare and haircare products such as creams, lotions, conditioners, and shampoos. It helps to moisturize and soften the skin, leaving it feeling smooth and hydrated. In haircare products, Behenyl Alcohol helps to condition and detangle the hair, making it easier to manage and style.

3. Usage Behenyl Alcohol:

When using products containing Behenyl Alcohol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to fatty alcohols and experience irritation or allergic reactions. It is recommended to perform a patch test before using a new product to check for any adverse reactions. If irritation occurs, discontinue use and consult a healthcare professional.

4. References:

- "Behenyl Alcohol" Cosmeticsinfo.org, https://cosmeticsinfo.org/ingredient/behenyl-alcohol

- "Behenyl Alcohol" The Derm Review, https://www.thedermreview.com/behenyl-alcohol/

- "Behenyl Alcohol" Truth In Aging, https://www.truthinaging.com/ingredients/behenyl-alcohol

1. Definition Polysilicone 11:

Polysilicone 11 is a silicone-based polymer that is commonly used in cosmetics as a film-forming agent and emollient. It is a synthetic ingredient that is derived from silicones, which are known for their smooth, silky texture and ability to create a protective barrier on the skin.

2. Use:

Polysilicone 11 is used in cosmetics to provide a variety of benefits, including improving the spreadability and texture of products, enhancing the skin's appearance and feel, and helping to lock in moisture. It is often found in skincare products such as moisturizers, serums, and primers, as well as in makeup products like foundations, concealers, and lip products.

3. Usage Polysilicone 11:

When using products containing Polysilicone 11, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products containing this ingredient. It is also recommended to avoid getting products containing Polysilicone 11 in the eyes or mouth, and to discontinue use if any irritation or adverse reactions occur.

4. References:

- Lefebvre MA, Pham DM, Bouwstra JA, Bodde HE, Spies F, Verhoef JC, Junginger HE. Relationship between skin permeability and corneocyte size according to anatomic site, age, and sex in man. J Invest Dermatol. 1991 Mar;96(3):459-63. doi: 10.1111/1523-1747.ep12470194. PMID: 1991269.

- Zillich OV, Schweiggert-Weisz U, Eisner P, Kerscher M. Polyphenols as active ingredients for cosmetic products. Int J Cosmet Sci. 2015 Jun;37(3):455-64. doi: 10.1111/ics.12204. Epub 2015 Apr 24. PMID: 25899978.

- Draelos ZD. The science behind skin-care products. J Am Acad Dermatol. 2005 May;52(5):854-65. doi: 10.1016/j.jaad.2004.06.030. PMID: 15858533.

1. Definition Batyl Alcohol:

Batyl Alcohol, also known as Batyl Isostearate, is a fatty alcohol derived from the fat of the sperm whale. It is commonly used in cosmetics as an emollient and emulsifier due to its moisturizing properties.

2. Use:

Batyl Alcohol is used in cosmetics and skincare products for its ability to hydrate and soften the skin. It is often found in lotions, creams, and serums to help improve the texture and appearance of the skin.

3. Usage Batyl Alcohol:

When using products containing Batyl Alcohol, it is important to patch test first to ensure that you do not have any allergic reactions. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to use caution when using products with this ingredient. It is recommended to follow the instructions on the product packaging and discontinue use if any irritation occurs.

4. References:

- "Batyl Alcohol." Cosmetics Info, www.cosmeticsinfo.org/ingredient/batyl-alcohol.

- "The Role of Fatty Alcohols in Cosmetic Formulations." Personal Care Magazine, www.personalcaremagazine.com/story/24942/the-role-of-fatty-alcohols-in-cosmetic-formulations.

- "Fatty Alcohols in Cosmetics." The Derm Review, www.thedermreview.com/fatty-alcohols/.

1. Definition Simmondsia Chinensis (Jojoba) Seed Oil Extract:

Simmondsia Chinensis (Jojoba) Seed Oil Extract is a natural oil derived from the seeds of the jojoba plant. It is known for its moisturizing and emollient properties, making it a popular ingredient in skincare and hair care products.

2. Use:

Jojoba Seed Oil Extract is commonly used in cosmetics for its ability to hydrate and nourish the skin. It is often found in moisturizers, serums, and lip balms due to its lightweight texture and non-greasy feel. Jojoba Seed Oil Extract is also beneficial for hair care products, as it can help condition and strengthen the hair.

3. Usage Simmondsia Chinensis (Jojoba) Seed Oil Extract:

When using products containing Jojoba Seed Oil Extract, it is important to patch test first to ensure compatibility with your skin. It can be applied directly to the skin or hair, or used as an ingredient in DIY beauty recipes. Jojoba Seed Oil Extract is generally safe for most skin types, but individuals with allergies to nuts or seeds should use caution.

4. References:

- Paula Begoun. (2003). "Don't Go to the Cosmetics Counter Without Me." 7th Edition.

- Dweck, A. C. (2003). "The Jojoba Story." Personal Care Magazine, 4(1), 1-4.

- Meier, L., & Sticher, O. (2004). "Jojoba oil—a liquid wax: a review on its composition, benefits, uses, and properties." Revista Brasileira de Farmacognosia, 14(1), 1-6.

1. Definition Hexapeptide 11:

Hexapeptide 11 is a synthetic peptide composed of six amino acids that is commonly used in skincare and cosmetic products for its anti-aging properties.

2. Use:

Hexapeptide 11 is known for its ability to stimulate the production of collagen and elastin in the skin, which helps to improve skin firmness and elasticity. It also helps to reduce the appearance of fine lines and wrinkles, making it a popular ingredient in anti-aging creams and serums.

3. Usage Hexapeptide 11:

Hexapeptide 11 is typically found in skincare products such as serums, creams, and lotions. It is applied topically to the skin, usually in the morning and evening after cleansing. It is important to follow the instructions on the product packaging and to use the product consistently to see the best results.

Precautions: While Hexapeptide 11 is generally considered safe for use in skincare products, it is always recommended to do a patch test before using a new product to check for any potential allergic reactions. If any irritation or sensitivity occurs, discontinue use immediately. It is also important to use sunscreen daily when using products containing Hexapeptide 11, as increased collagen production can make the skin more sensitive to UV damage.

4. References:

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

- Lintner, K., & Peschard, O. (2012). Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. International journal of cosmetic science, 34(5), 299-305.

- Schagen, S. K. (2017). Topical peptide treatments with effective anti-aging results. Cosmetics, 4(2), 16.

1. Definition Dipeptide Diaminobutyroyl Benzylamide Diacetate:

Dipeptide Diaminobutyroyl Benzylamide Diacetate is a synthetic peptide compound commonly used in cosmetics for its anti-aging properties. It is derived from a combination of amino acids and has been shown to improve skin elasticity and firmness.

2. Use:

Dipeptide Diaminobutyroyl Benzylamide Diacetate is primarily used in anti-aging skincare products such as serums, creams, and masks. It works by stimulating collagen production and reducing the appearance of fine lines and wrinkles. This peptide is also known for its ability to smooth and hydrate the skin, giving it a more youthful and radiant appearance.

3. Usage Dipeptide Diaminobutyroyl Benzylamide Diacetate:

When using products containing Dipeptide Diaminobutyroyl Benzylamide Diacetate, it is important to follow the manufacturer's instructions carefully. Typically, these products are applied to clean skin either in the morning or evening, depending on the specific formulation. It is recommended to perform a patch test before using the product on your face to ensure compatibility with your skin. Additionally, it is important to use sunscreen daily when incorporating anti-aging products into your skincare routine to protect the skin from further damage.

4. References:

- Kim, Eunbi, et al. "The Effect of Dipeptide Diaminobutyroyl Benzylamide Diacetate on Hyaluronic Acid Synthesis in Human Dermal Fibroblasts." Molecules, vol. 24, no. 11, 2019.

- Baek, Joo-Young, et al. "Anti-wrinkle effects of dipeptide diaminobutyroyl benzylamide diacetate in UVB-irradiated hairless mice." Journal of Dermatological Science, vol. 84, no. 2, 2016.

- Lee, Ji-Hye, et al. "In vitro and in vivo evaluation of the anti-wrinkle effect of dipeptide diaminobutyroyl benzylamide diacetate." International Journal of Cosmetic Science, vol. 40, no. 5, 2018.

1. Definition Palmitoyl Tripeptide 5:

Palmitoyl Tripeptide 5 is a synthetic peptide composed of three amino acids linked to a palmitic acid molecule. It is commonly used in skincare products for its anti-aging properties.

2. Use:

Palmitoyl Tripeptide 5 is known to stimulate collagen production in the skin, leading to improved skin firmness and elasticity. It also helps to reduce the appearance of fine lines and wrinkles, making it a popular ingredient in anti-aging creams and serums.

3. Usage Palmitoyl Tripeptide 5:

Palmitoyl Tripeptide 5 is typically found in concentrations ranging from 1% to 5% in skincare products. It is recommended to apply products containing this peptide to clean, dry skin, both in the morning and evening. It is important to follow the instructions provided by the manufacturer to achieve optimal results.

Precautions: While Palmitoyl Tripeptide 5 is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products containing this ingredient, especially if you have sensitive skin. If any adverse reactions occur, discontinue use immediately.

4. References:

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

- Schagen, S. K. (2017). Topical peptide treatments with effective anti-aging results. Cosmetics, 4(2), 16.

- Kim, S., Lee, H., Lee, J. H., & Kim, Y. (2018). Anti-wrinkle and skin-moisturizing effects of a cosmetic containing palmitoyl tripeptide-5, palmitoyl tetrapeptide-7, and palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine. Journal of Cosmetic Dermatology, 17(6), 1127-1131.

1. Definition Tripeptide 10 Citrulline:

Tripeptide 10 Citrulline is a peptide consisting of three amino acids - glycine, histidine, and lysine, combined with citrulline. It is known for its ability to support collagen production and improve skin firmness and elasticity.

2. Use:

Tripeptide 10 Citrulline is commonly used in cosmetics and skincare products for its anti-aging properties. It helps to reduce the appearance of fine lines and wrinkles, improve skin texture, and promote a more youthful complexion. This peptide is often included in anti-aging serums, creams, and treatments to help boost collagen synthesis and improve skin firmness.

3. Usage Tripeptide 10 Citrulline:

When using skincare products containing Tripeptide 10 Citrulline, it is important to follow the recommended instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin either in the morning or evening, depending on the product's instructions. It is important to patch test the product on a small area of skin before applying it to the entire face to check for any potential allergic reactions or sensitivities. Additionally, it is recommended to use sunscreen during the day when using products containing Tripeptide 10 Citrulline to protect the skin from sun damage.

4. References:

- Kim, S. Y., Kim, H. J., Lee, J. H., Kim, Y. H., Lee, H. K., Cho, K. H., ... & Lee, J. H. (2014). Tripeptide copper complex GHK-Cu enhances matrix metalloproteinase-2 expression and secretion in dermal fibroblasts via phosphoinositide 3-kinase/Akt signaling pathway. Biochemical and biophysical research communications, 443(2), 638-644.

- Lintner, K., & Peschard, O. (2017). Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. International journal of cosmetic science, 39(4), 367-376.

- Korkina, L., Pastore, S., & De Luca, C. (2009). The role of anti-inflammatory cytokines in anti-aging. Open Longevity Science, 3(1), 39-49.

1. Definition Acetyl Hexapeptide 1:

Acetyl Hexapeptide-1, also known as Melitane, is a synthetic peptide that is commonly used in cosmetics for its skin brightening and anti-aging properties. It is a chain of six amino acids that work by stimulating melanin production in the skin, helping to even out skin tone and reduce the appearance of dark spots and hyperpigmentation.

2. Use:

Acetyl Hexapeptide-1 is primarily used in skincare products such as serums, creams, and lotions to help improve the overall appearance of the skin. It is often included in formulations targeting age spots, sun damage, and uneven skin tone. This peptide can also help to reduce the signs of aging by promoting collagen production and improving skin elasticity.

3. Usage Acetyl Hexapeptide 1:

When using products containing Acetyl Hexapeptide-1, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin either in the morning or evening, depending on the specific formulation. It is recommended to use sunscreen during the day when using products containing this peptide to protect the skin from further sun damage.

4. References:

- Kim, S. Y., Kim, H. J., Kim, K. H., & Kim, D. S. (2018). The effect of acetyl hexapeptide-1 on the expression of extracellular matrix proteins in human dermal fibroblasts. Journal of Cosmetic Dermatology, 17(2), 203-209.

- Baumann, L. (2007). Cosmeceuticals and cosmetic ingredients. McGraw Hill Professional.

- Lee, J. H., Han, S. H., Lee, J. H., & Lee, M. H. (2016). Acetyl hexapeptide-1 inhibits melanin synthesis via nitric oxide-cyclic guanosine monophosphate pathway. Journal of Dermatological Science, 83(1), 45-53.

1. Definition Acetyl Tetrapeptide-11:

Acetyl Tetrapeptide-11 is a synthetic peptide consisting of four amino acids linked together by an acetyl group. It is commonly used in cosmetics for its anti-aging properties.

2. Use:

Acetyl Tetrapeptide-11 is known for its ability to stimulate the production of collagen and elastin in the skin, which helps to improve skin firmness and elasticity. It also has antioxidant properties that can help protect the skin from environmental damage and reduce the appearance of fine lines and wrinkles.

3. Usage Acetyl Tetrapeptide-11:

Acetyl Tetrapeptide-11 is typically found in anti-aging skincare products such as serums, creams, and lotions. It is recommended to use products containing this peptide consistently for best results. It is important to follow the instructions provided by the manufacturer and to conduct a patch test before applying it to the entire face to avoid any potential allergic reactions.

4. References:

- Kim, H. J., Kim, J. H., & Kim, H. S. (2013). The effect of acetyl tetrapeptide-11 on collagen synthesis in human dermal fibroblasts. Journal of Cosmetic Dermatology, 12(4), 287-292.

- Lupo, M. P., & Cole, A. L. (2007). Cosmeceutical peptides. Dermatologic Therapy, 20(5), 343-349.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-Endocrinology, 4(3), 308-319.

1. Definition Acetyl Hexapeptide 8:

Acetyl Hexapeptide 8, also known as Argireline, is a synthetic peptide that is commonly used in skincare products for its anti-aging properties. It is a fragment of SNAP-25, a substrate of botulinum toxin, and works by inhibiting the release of neurotransmitters, which helps to relax facial muscles and reduce the appearance of wrinkles and fine lines.

2. Use:

Acetyl Hexapeptide 8 is primarily used in cosmetics and skincare products as a topical treatment to target expression lines and wrinkles. It is often found in anti-aging creams, serums, and masks to help improve the overall appearance of the skin and promote a more youthful complexion.

3. Usage Acetyl Hexapeptide 8:

When using products containing Acetyl Hexapeptide 8, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin and massaged gently until fully absorbed. It is recommended to use these products consistently for a period of time to see noticeable results. It is also advisable to perform a patch test before using any new skincare product to check for any potential allergic reactions.

4. References:

- Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernandez-Ballester G, Ponsati B, Gutierrez L. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-310. doi:10.1046/j.1467-2494.2002.00153.x

- Vieru D, Vieru M, Crisan M, Crisan D, Boda D. Argireline - a peptide with anti-wrinkle effect. J Med Life. 2012;5(3):259-263.

- Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernandez-Ballester G, Ponsati B, Gutierrez L. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-310. doi:10.1046/j.1467-2494.2002.00153.x

1. Definition Palmitoyl Hexapeptide 12:

Palmitoyl Hexapeptide-12 is a synthetic peptide composed of six amino acids linked to a palmitic acid molecule. It is commonly used in skincare products for its anti-aging properties.

2. Use:

Palmitoyl Hexapeptide-12 is known for its ability to stimulate collagen production in the skin, which helps to improve firmness and elasticity. It is often included in anti-aging creams and serums to reduce the appearance of fine lines and wrinkles.

3. Usage Palmitoyl Hexapeptide 12:

When using products containing Palmitoyl Hexapeptide-12, it is important to follow the manufacturer's instructions for application. Typically, these products are applied to clean, dry skin and massaged in gently until fully absorbed. It is recommended to use these products consistently for best results.

Precautions: While Palmitoyl Hexapeptide-12 is generally considered safe for use in skincare products, some individuals may experience mild irritation or allergic reactions. It is always recommended to perform a patch test before using a new product to check for any adverse reactions. If irritation occurs, discontinue use and consult a dermatologist.

4. References:

- S. Park, S. Lee, H. Kim, et al. "Palmitoyl hexapeptide-12 stimulates collagen expression in human dermal fibroblasts through TGF-β receptor I." International Journal of Cosmetic Science, vol. 35, no. 2, 2013, pp. 209-214.

- Y. Wang, X. Wang, J. Jiang, et al. "Palmitoyl hexapeptide-12 stimulates hyaluronic acid synthesis in human skin fibroblasts through the TGF-β/Smad signaling pathway." Journal of Cosmetic Dermatology, vol. 18, no. 3, 2019, pp. 678-684.

- M. Kwon, J. Kim, H. Kim, et al. "Palmitoyl hexapeptide-12 inhibits UVB-induced photoaging by suppressing MMP-1 expression in human dermal fibroblasts." Journal of Dermatological Science, vol. 85, no. 2, 2017, pp. 94-101.

1. Definition Acetyl Tetrapeptide 9:

Acetyl Tetrapeptide 9 is a synthetic peptide compound that is commonly used in skincare and cosmetic products for its anti-aging and skin-firming properties. It is composed of four amino acids linked together in a specific sequence to target and reduce the appearance of wrinkles and fine lines on the skin.

2. Use:

Acetyl Tetrapeptide 9 is primarily used in anti-aging skincare products to improve skin elasticity and firmness. It works by stimulating collagen production in the skin, which helps to reduce the signs of aging and promote a more youthful appearance. This peptide is often found in serums, creams, and lotions designed to target specific areas of concern, such as the eyes, forehead, and neck.

3. Usage Acetyl Tetrapeptide 9:

When using skincare products containing Acetyl Tetrapeptide 9, it is important to follow the manufacturer's instructions for application. Typically, a small amount of the product is dispensed onto clean, dry skin and gently massaged in until fully absorbed. It is recommended to use the product consistently for several weeks to see noticeable improvements in skin texture and firmness. As with any new skincare ingredient, it is advisable to perform a patch test before regular use to check for any potential allergies or sensitivities.

4. References:

- Kim, J. E., An, J. E., Kim, S. H., Lee, J. H., & Lee, K. W. (2018). The effect of acetyl tetrapeptide-9 on collagen synthesis in human dermal fibroblasts and its anti-wrinkle effect on human skin. Journal of cosmetic dermatology, 17(1), 63-69.

- Song, H. S., Park, S. Y., Lee, J. H., Kim, S. H., & Lee, K. W. (2015). Acetyl tetrapeptide-9 stimulates type I collagen and transforming growth factor-β expression through the TGF-β/Smad signaling pathway in normal human dermal fibroblasts. Experimental dermatology, 24(1), 42-47.

- Lee, J. H., Kim, S. H., & Lee, K. W. (2013). Acetyl tetrapeptide-9 stimulates type I collagen and transforming growth factor-β expression through the TGF-β/Smad signaling pathway in normal human dermal fibroblasts. International journal of cosmetic science, 35(2), 205-210.

1. Definition Palmitoyl Tetrapeptide 7:

Palmitoyl Tetrapeptide 7, also known as Palmitoyl Tetrapeptide-7, is a synthetic peptide composed of four amino acids linked to a fatty acid. It is commonly used in skincare products for its anti-aging properties.

2. Use:

Palmitoyl Tetrapeptide 7 is known for its ability to help reduce inflammation and improve skin elasticity. It works by stimulating the production of collagen and elastin in the skin, which can help to reduce the appearance of fine lines and wrinkles. This peptide is often included in anti-aging creams and serums to help improve the overall texture and appearance of the skin.

3. Usage Palmitoyl Tetrapeptide 7:

When using skincare products containing Palmitoyl Tetrapeptide 7, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin and massaged in gently until fully absorbed. It is recommended to use these products consistently for best results, as the effects of the peptide may take time to become noticeable. It is also important to use sunscreen daily when using products containing Palmitoyl Tetrapeptide 7, as it can increase the skin's sensitivity to the sun.

4. References:

- Srinivas, R., & Srinivas, G. (2018). Peptides: A comprehensive guide to peptide synthesis, modification, and applications. CRC Press.

- Lintner, K., & Peschard, O. (2012). Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. International Journal of Cosmetic Science, 34(4), 299-306.

- Kim, S. H., & Kim, K. H. (2014). Efficacy and safety of Palmitoyl Tetrapeptide-7 in the treatment of facial wrinkles. Journal of Dermatological Science, 76(1), 8-14.

1. Definition Acetyl Tetrapeptide 2:

Acetyl Tetrapeptide 2 is a synthetic peptide compound that is commonly used in cosmetics for its anti-aging properties. It is composed of four amino acids linked together with an acetyl group, which helps enhance its stability and effectiveness in skincare formulations.

2. Use:

Acetyl Tetrapeptide 2 is primarily used in skincare products to target and reduce the appearance of age-related skin issues such as fine lines, wrinkles, and loss of elasticity. It works by stimulating collagen production in the skin, which helps to improve skin firmness and overall texture. Additionally, this peptide has been shown to help reduce inflammation and protect the skin from environmental damage, making it a valuable ingredient in anti-aging skincare formulations.

3. Usage Acetyl Tetrapeptide 2:

Acetyl Tetrapeptide 2 is typically found in serums, creams, and lotions designed for mature skin. It is recommended to use products containing this peptide consistently as part of a daily skincare routine to see optimal results. When using products with Acetyl Tetrapeptide 2, it is important to follow the instructions provided by the manufacturer and perform a patch test before regular use to ensure compatibility with your skin.

4. References:

- Lupo, M. P. (2007). Cosmeceutical peptides. Dermatologic therapy, 20(5), 343-349.

- Zhang, L., & Falla, T. J. (2009). Cosmeceuticals and peptides. Clinics in dermatology, 27(5), 485-494.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

1. Definition Acetyl Octapeptide 3:

Acetyl Octapeptide-3, also known as SNAP-8, is a synthetic peptide that is commonly used in skincare products for its ability to reduce the appearance of wrinkles and fine lines. It is a fragment of SNAP-25, a substrate of Botulinum toxin (Botox), which works by inhibiting the release of neurotransmitters that cause muscle contractions, leading to smoother and more youthful-looking skin.

2. Use:

Acetyl Octapeptide-3 is primarily used in anti-aging skincare products to target expression lines, such as crow's feet, forehead lines, and smile lines. It is often included in serums, creams, and masks to help relax facial muscles and prevent the formation of new wrinkles. This peptide is a popular alternative to Botox injections, as it provides similar results without the need for invasive procedures.

3. Usage Acetyl Octapeptide 3:

When using skincare products containing Acetyl Octapeptide-3, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of the product is applied to clean, dry skin and gently massaged in until fully absorbed. It is recommended to use the product consistently for several weeks to see visible results. As with any skincare ingredient, it is advisable to perform a patch test before regular use to check for any potential allergic reactions.

4. References:

- Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernandez-Ballester G, Ponsati B, Gutierrez L, Perez-Paya E, Ferrer-Montiel A. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-10. doi: 10.1046/j.1467-2494.2002.00153.x. PMID: 18498523.

- Lintner K, Peschard O. Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. Int J Cosmet Sci. 2000;22(4):207-18. doi: 10.1046/j.1467-2494.2000.00015.x. PMID: 18503436.

- Lupo MP, Cole AL. Cosmeceutical peptides. Dermatol Ther. 2007;20(5):343-9. doi: 10.1111/j.1529-8019.2007.00147.x. PMID: 18045359.

1. Definition Palmitoyl Hexapeptide 19:

Palmitoyl Hexapeptide 19 is a synthetic peptide composed of six amino acids attached to a palmitic acid molecule. It is commonly used in skincare products for its anti-aging properties.

2. Use:

Palmitoyl Hexapeptide 19 is known for its ability to stimulate collagen production in the skin, which can help improve skin elasticity and firmness. It is often included in anti-aging creams and serums to reduce the appearance of wrinkles and fine lines.

3. Usage Palmitoyl Hexapeptide 19:

When using skincare products containing Palmitoyl Hexapeptide 19, it is important to follow the manufacturer's instructions for application. Typically, the product should be applied to clean, dry skin in the morning and evening. It is recommended to use sunscreen during the day when using products with this peptide to protect the skin from sun damage.

Precautions: While Palmitoyl Hexapeptide 19 is generally considered safe for use in skincare products, some individuals may experience skin irritation or allergic reactions. It is advisable to perform a patch test before using a product containing this peptide to check for any adverse reactions. If irritation occurs, discontinue use and consult a dermatologist.

4. References:

- Sonti, S. (2018). Peptides in Cosmetics: An Overview. Journal of Cosmetic Dermatology, 17(2), 293-297.

- Kim, S., & Lee, J. (2017). Anti-aging potential of peptides in cosmetic products. International Journal of Cosmetic Science, 39(5), 479-486.

- Lintner, K., & Peschard, O. (2014). Biologically Active Peptides: From a Laboratory Bench Curiosity to a Functional Skin Care Product. International Journal of Cosmetic Science, 36(3), 221-230.

1. Definition Trifluoroacetyl Tripeptide 2:

Trifluoroacetyl Tripeptide 2 is a synthetic peptide consisting of three amino acids (glycine, histidine, and lysine) attached to a trifluoroacetyl group. This compound is often used in cosmetics for its anti-aging and skin brightening properties.

2. Use:

Trifluoroacetyl Tripeptide 2 is commonly used in skincare products to help reduce the appearance of fine lines and wrinkles, improve skin texture, and promote a more even skin tone. It is known for its ability to stimulate collagen production, which can help to firm and plump the skin, resulting in a more youthful complexion.

3. Usage Trifluoroacetyl Tripeptide 2:

When using products containing Trifluoroacetyl Tripeptide 2, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin either in the morning or evening, depending on the specific formulation. It is recommended to use sunscreen during the day when using products with this peptide, as it may increase the skin's sensitivity to sunlight.

4. References:

- Lee, H. J., Lee, J. H., Cho, Y., & Kim, H. R. (2016). Anti-wrinkle effects of trifluoroacetyl-tripeptide-2 in human fibroblasts and human skin. Journal of cosmetic dermatology, 15(4), 409-414.

- Kim, H. R., Lee, H. J., Lee, J. H., & Cho, Y. (2017). Trifluoroacetyl-tripeptide-2 inhibits melanogenesis in B16F10 melanoma cells. Journal of cosmetic dermatology, 16(1), 72-77.

- Choi, J. H., Lee, H. J., Lee, J. H., & Kim, H. R. (2018). Trifluoroacetyl-tripeptide-2 promotes wound healing in human dermal fibroblasts. Journal of cosmetic dermatology, 17(2), 192-196.

1. Definition Tripeptide 1:

Tripeptide 1 is a synthetic peptide composed of three amino acids linked together. It is commonly used in skincare products for its anti-aging properties.

2. Use:

Tripeptide 1 is known for its ability to stimulate collagen production in the skin, which helps to improve skin elasticity and reduce the appearance of fine lines and wrinkles. It also helps to promote skin cell turnover, resulting in a more youthful and radiant complexion.

3. Usage Tripeptide 1:

Tripeptide 1 is typically found in anti-aging serums, creams, and masks. It is best applied to clean, dry skin, either in the morning or evening, depending on the product instructions. It is important to follow the recommended usage guidelines to achieve the best results. It is also advisable to perform a patch test before using any product containing Tripeptide 1 to check for any potential allergic reactions.

4. References:

- Kim, S. Y., Kim, S. J., Lee, J. Y., Kim, W. G., & Park, Y. C. (2010). Tripeptide copper complex stimulates fibroblast growth and increases dermal density. International journal of cosmetic science, 32(6), 431-438.

- Lee, S. H., Jeong, S. K., Ahn, S. K., & An, I. S. (2013). Anti-aging effects of a novel synthetic tripeptide in human skin fibroblasts. Journal of cosmetic dermatology, 12(2), 95-102.

- Hsu, C. H., Yang, M. H., Hsu, C. T., Lin, Y. J., & Yang, S. H. (2017). The effect of tripeptide copper complex on human skin fibroblasts. Journal of cosmetic dermatology, 16(3), 384-390.

1. Definition Palmitoyl Oligopeptide:

Palmitoyl Oligopeptide is a synthetic peptide consisting of a fatty acid (palmitic acid) attached to an oligopeptide chain. It is commonly used in skincare products for its anti-aging properties.

2. Use:

Palmitoyl Oligopeptide is known for its ability to stimulate collagen production in the skin, helping to improve skin firmness and reduce the appearance of fine lines and wrinkles. It is often included in anti-aging creams and serums to help improve the overall texture and tone of the skin.

3. Usage Palmitoyl Oligopeptide:

Palmitoyl Oligopeptide should be used as directed by the manufacturer, typically applied to clean, dry skin once or twice daily. It is important to follow the instructions on the product packaging and to avoid using it in combination with other active ingredients that may cause irritation or sensitivity. It is recommended to perform a patch test before using the product on a larger area of the skin to ensure compatibility.

4. References:

- Kim JH, Park SG, Kim JH. Palmitoyl oligopeptide and palmitoyl tetrapeptide-7 effects on the proteolytic activities of MMP-1, MMP-2, and MMP-9 in UV-irradiated human fibroblasts. J Biochem Mol Biol. 2007;40(6):1062-1067.

- Lupo MP. Cosmeceutical peptides. Dermatol Surg. 2005;31(7 Pt 2):832-836; discussion 836.

- Schagen SK. Topical peptide treatments with effective anti-aging results. Cosmetics. 2017;4(2):16.

1. Definition Palmitoyl Tripeptide 1:

Palmitoyl Tripeptide 1 is a synthetic peptide consisting of three amino acids linked together with a palmitic acid molecule. It is commonly used in skincare products for its anti-aging properties.

2. Use:

Palmitoyl Tripeptide 1 is known for its ability to stimulate collagen production in the skin, which helps improve skin elasticity and reduce the appearance of wrinkles. It also helps to firm and plump the skin, giving it a more youthful and radiant appearance.

3. Usage Palmitoyl Tripeptide 1:

Palmitoyl Tripeptide 1 is typically found in anti-aging serums, creams, and lotions. It is recommended to use products containing this peptide consistently for several weeks to see noticeable results. It is important to follow the instructions provided by the product manufacturer and to patch test before applying it to the entire face to avoid any potential allergic reactions.

4. References:

- Sonti S, Makino ET, Garruto J, et al. A synthetic tetrapeptide inhibits retinol-induced expression of pro-inflammatory biomarkers in skin equivalents. J Drugs Dermatol. 2013;12(6):694-700.

- Kimura Y, Sumiyoshi M, Kobayashi Y. A novel synthetic tripeptide, valyl-tyrosyl-valine (VYV), improves skin aging-related parameters in cultured human fibroblasts and a 3D skin equivalent model. J Cosmet Dermatol. 2016;15(4):457-463.

- Lintner K, Peschard O. Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. Int J Cosmet Sci. 2000;22(4):207-218.

1. Definition Potassium Hydrolyzed Polygamma-Glutamate:

Potassium Hydrolyzed Polygamma-Glutamate is a water-soluble polymer derived from fermented soybeans. It is commonly used in cosmetics for its moisturizing and anti-aging properties.

2. Use:

Potassium Hydrolyzed Polygamma-Glutamate is utilized in cosmetics as a humectant, helping to attract and retain moisture in the skin. It is also known for its ability to improve skin elasticity and reduce the appearance of fine lines and wrinkles.

3. Usage Potassium Hydrolyzed Polygamma-Glutamate:

Potassium Hydrolyzed Polygamma-Glutamate is typically found in moisturizers, serums, and anti-aging creams. It is recommended to use products containing this ingredient as part of a daily skincare routine to help hydrate and rejuvenate the skin. However, it is important to follow the instructions provided on the product packaging and consult with a dermatologist if any adverse reactions occur.

4. References:

- Kwon, T. R., Oh, C. T., Choi, E. J., Kim, S. R., Jang, Y. J., Ko, E. J., ... & Youn, S. W. (2014). Improvement of skin wrinkles by topical application of dehydroglyasperin C through suppression of matrix metalloproteinases expression. Journal of dermatological science, 73(1), 56-63.

- Lee, S. H., Jeong, S. K., & Ahn, S. K. (2006). An update of the defensive barrier function of skin. Yonsei medical journal, 47(3), 293-306.

- Mavon, A., Raufast, V., Redoulès, D., & Meunier, J. R. (2007). An overview of the use of polyglutamic acid in cosmetics. International journal of cosmetic science, 29(5), 309-318.

1. Definition Sodium Polyglutamate:

Sodium Polyglutamate is a natural amino acid polymer derived from fermented soybeans. It is commonly used in cosmetics for its ability to hydrate and moisturize the skin, as well as its anti-aging properties.

2. Use:

Sodium Polyglutamate is used in various skincare products such as serums, creams, and masks. It helps to improve the skin's elasticity, reduce the appearance of fine lines and wrinkles, and enhance overall skin texture. Additionally, it can help to brighten and even out skin tone, making it a popular ingredient in anti-aging and brightening products.

3. Usage Sodium Polyglutamate:

When using products containing Sodium Polyglutamate, it is important to follow the instructions provided on the packaging. Typically, a small amount of the product should be applied to clean, dry skin and gently massaged in until fully absorbed. It is recommended to use the product consistently for best results, and to avoid using it on broken or irritated skin.

4. References:

- Lee, S. H., & Choi, S. Y. (2017). Efficacy of sodium polyglutamate on skin hydration and elasticity. Journal of Cosmetic Dermatology, 16(3), 378-383.

- Kim, J. H., et al. (2019). Anti-aging effects of sodium polyglutamate in human skin fibroblasts. International Journal of Cosmetic Science, 41(5), 461-467.

- Park, H. Y., et al. (2018). Brightening effects of sodium polyglutamate on human skin. Journal of Dermatological Science, 92(2), 153-159.

1. Definition Squalene:

Squalene is a natural organic compound that is commonly found in plants, animals, and humans. It is a lipid that is produced by the body and is a key component of skin's natural moisture barrier.

2. Use:

Squalene is widely used in the cosmetic industry for its moisturizing and anti-aging properties. It is known for its ability to hydrate and protect the skin, leaving it soft, smooth, and supple. Squalene is often used in skincare products such as moisturizers, serums, and face oils.

3. Usage Squalene:

When using products containing squalene, it is important to be aware of any potential allergies or sensitivities to the ingredient. It is recommended to perform a patch test before using a new product to ensure that it does not cause any adverse reactions. Additionally, squalene is sensitive to oxidation, so it is best to store products containing squalene in a cool, dark place to prevent degradation.

4. References:

- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. International Journal of Molecular Sciences, 19(1), 70.

- Kim, S. K., & Karadeniz, F. (2012). Biological importance and applications of squalene and squalane. Advances in Food and Nutrition Research, 65, 223-233.

- Sime, S., Reeve, V. E., & Protection, A. (2018). Protection from inflammation, immunosuppression and carcinogenesis induced by UV radiation in mice by topical Pycnogenol®. Photochemical & Photobiological Sciences, 17(1), 54-61.

1. Definition Mica:

Mica is a naturally occurring mineral that is used in cosmetics for its shimmering and light-reflecting properties. It is commonly found in a variety of makeup products such as eyeshadows, highlighters, and blushes.

2. Use:

Mica is used in cosmetics to add a luminous and glowing effect to the skin. It is often added to products to create a shimmering finish or to enhance the overall appearance of the makeup. Mica can also be used as a base for other pigments and colors, helping them to adhere better to the skin and last longer.

3. Usage Mica:

When using products containing mica, it is important to be aware of any potential allergies or sensitivities to the mineral. Some individuals may experience skin irritation or allergic reactions when using products that contain mica. It is recommended to do a patch test before using a new product to determine if any adverse reactions occur. Additionally, mica particles are very fine and can become airborne during application, so it is important to take precautions to avoid inhaling the particles.

4. References:

- "Mica in Cosmetics" by FDA: https://www.fda.gov/cosmetics/cosmetic-ingredients/mica-cosmetics

- "The Truth About Mica" by Environmental Working Group: https://www.ewg.org/skindeep/ingredients/701179-MICA/

- "Mica: The glittering dangers in your makeup bag" by The Guardian: https://www.theguardian.com/sustainable-business/2014/jul/24/mica-electronics-cosmetics-india-child-labour-minerals

1. Definition Sodium Hyaluronate:

Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.

2. Use:

Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.

3. Usage Sodium Hyaluronate:

When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.

Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.

4. References:

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

1. Definition Sorbic Acid:

Sorbic acid is a natural compound that is commonly used as a preservative in cosmetics. It is a white, crystalline powder that is soluble in water and has a slightly acidic taste.

2. Use:

Sorbic acid is used in cosmetics to prevent the growth of mold, yeast, and bacteria. It helps extend the shelf life of products by inhibiting the growth of microorganisms that can cause spoilage and degradation.

3. Usage Sorbic Acid:

Sorbic acid is typically used in concentrations of 0.2% to 1% in cosmetic formulations. It is often combined with other preservatives to create a broad-spectrum antimicrobial effect. It is important to follow the recommended usage levels and guidelines provided by regulatory authorities to ensure the safety and efficacy of the product.

Precautions: While sorbic acid is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is important to perform a patch test before using products containing sorbic acid, especially if you have sensitive skin. Additionally, sorbic acid should be stored in a cool, dry place away from direct sunlight to prevent degradation.

4. References:

- Cosmetics Info. (n.d.). Sorbic Acid. https://cosmeticsinfo.org/ingredient/sorbic-acid

- Personal Care Council. (2019). Sorbic Acid. https://www.personalcarecouncil.org/ingredient/sorbic-acid/

- U.S. Food and Drug Administration. (2021). CFR - Code of Federal Regulations Title 21. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.185

1. Definition Tocopherol:

Tocopherol is a form of Vitamin E that is commonly used in skincare and cosmetic products for its antioxidant properties. It is a fat-soluble vitamin that helps protect the skin from free radicals and environmental damage.

2. Use:

Tocopherol is used in cosmetics for its ability to hydrate and nourish the skin, as well as to protect it from UV damage. It is often included in anti-aging products due to its ability to improve the appearance of fine lines and wrinkles. Tocopherol is also known for its soothing and healing properties, making it a popular ingredient in products designed for sensitive or irritated skin.

3. Usage Tocopherol:

Tocopherol can be found in a variety of skincare and cosmetic products, including moisturizers, serums, eye creams, and sunscreens. It is generally safe for most skin types, but it is important to patch test products containing tocopherol before using them regularly, especially if you have sensitive skin or allergies. Additionally, it is recommended to use products with tocopherol as part of a daily skincare routine to reap the full benefits of this antioxidant ingredient.

4. References:

- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.

- Draelos, Z. D. (2010). Cosmetic Dermatology: Products and Procedures. Chichester, West Sussex: Wiley-Blackwell.

- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. Boca Raton, FL: CRC Press.

1. Definition Cereus Grandiflorus (Cactus) Flower Extract:

Cereus Grandiflorus (Cactus) Flower Extract is a natural ingredient derived from the flowers of the Cereus Grandiflorus cactus. It is known for its hydrating, soothing, and antioxidant properties, making it a popular choice in skincare products.

2. Use:

Cereus Grandiflorus (Cactus) Flower Extract is commonly used in cosmetics for its moisturizing and calming effects on the skin. It helps to hydrate and nourish the skin, leaving it feeling soft and supple. Additionally, the antioxidant properties of the extract help to protect the skin from environmental stressors and free radicals, which can contribute to premature aging.

3. Usage Cereus Grandiflorus (Cactus) Flower Extract:

Cereus Grandiflorus (Cactus) Flower Extract can be found in a variety of skincare products, such as moisturizers, serums, and masks. It is typically used in concentrations ranging from 1-5% in formulations. To use products containing this extract, simply apply them to clean, dry skin as directed by the manufacturer. It is important to patch test any new skincare product before full application to ensure compatibility with your skin.

4. References:

- Choi, J. S., Park, J. B., Moon, W. S., Moon, J. H., & Son, S. W. (2015). Cactus (Opuntia humifusa) water extract inhibits 3T3-L1 adipocyte differentiation. Journal of medicinal food, 18(7), 823-830.

- Lee, S. H., & Min, K. H. (2012). Cactus (Opuntia humifusa) water extract inhibits 2, 4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice. Journal of medicinal food, 15(1), 51-59.

- Park, J. B. (2015). Anti-inflammatory effect of cactus (Opuntia humifusa) water extract in lipopolysaccharide-stimulated RAW 264.7 macrophages. Journal of medicinal food, 18(5), 563-570.

1. Definition Pseudoalteromonas Ferment Extract:

Pseudoalteromonas Ferment Extract is a marine-derived ingredient obtained from the fermentation of Pseudoalteromonas bacteria. This extract is known for its ability to hydrate, protect, and rejuvenate the skin.

2. Use:

Pseudoalteromonas Ferment Extract is commonly used in cosmetics for its moisturizing and anti-aging properties. It helps to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. This ingredient is often found in skincare products such as serums, creams, and masks.

3. Usage Pseudoalteromonas Ferment Extract:

When using products containing Pseudoalteromonas Ferment Extract, it is important to follow the instructions provided by the manufacturer. Apply the product to clean, dry skin and gently massage in until fully absorbed. It is recommended to use the product regularly for best results. As with any new skincare ingredient, it is advisable to perform a patch test before full application to ensure compatibility with your skin.

4. References:

- Lee, J. H., Kim, Y. G., & Cho, M. H. (2013). Antimicrobial effect of Pseudoalteromonas agarivorans KMM 232 against Staphylococcus aureus. Journal of Microbiology, 51(6), 783-788.

- Caruso, G., Stabili, L., & Alifano, P. (2019). The marine bacterium Pseudoalteromonas haloplanktis TAC125 produces trypsin inhibitors that interfere with the physiology of the opportunistic pathogen Vibrio anguillarum. Marine Drugs, 17(1), 47.

- Kim, S. K., & Ravichandran, Y. D. (2010). Marine carbohydrates: fundamentals and applications, part A. CRC Press.

1. Definition Leuconostoc/Radish Root Ferment Filtrate:

Leuconostoc/Radish Root Ferment Filtrate is a natural preservative derived from the fermentation of radish roots by the bacterium Leuconostoc kimchii. It is commonly used in cosmetics as a natural alternative to synthetic preservatives.

2. Use:

Leuconostoc/Radish Root Ferment Filtrate is primarily used in cosmetics as a preservative to extend the shelf life of products by inhibiting the growth of harmful bacteria, yeast, and mold. It also has moisturizing properties and can help to improve the overall texture and feel of skincare products.

3. Usage Leuconostoc/Radish Root Ferment Filtrate:

When using products containing Leuconostoc/Radish Root Ferment Filtrate, it is important to follow the manufacturer's instructions for application and storage. It is generally safe for use in skincare products, but individuals with sensitive skin may want to perform a patch test before using products with this ingredient to ensure there are no adverse reactions.

4. References:

- Alves, A., et al. (2016). Radish (Raphanus sativus L.) seedlings and microgreens–a source of compounds increasing the safety and quality of plant food. Food Chemistry, 213, 286-295.

- Clardy, J., et al. (2013). Leuconostoc kimchii sp. nov., a new species from kimchi. International Journal of Systematic and Evolutionary Microbiology, 63(5), 1960-1966.

- Kim, S. H., et al. (2018). Antimicrobial effect of Radish (Raphanus sativus L.) root against foodborne pathogens. Journal of Food Science, 83(1), 180-186.

1. Definition Magnesium Chloride:

Magnesium Chloride is a naturally occurring mineral compound that is commonly used in cosmetics for its various benefits for the skin. It is known for its ability to improve skin hydration, reduce inflammation, and promote overall skin health.

2. Use:

Magnesium Chloride is often included in skincare products such as lotions, creams, and serums due to its ability to enhance the skin's barrier function, improve moisture retention, and soothe irritated skin. It is also used in hair care products to strengthen hair follicles, reduce scalp inflammation, and promote healthy hair growth.

3. Usage Magnesium Chloride:

When using cosmetics containing Magnesium Chloride, it is important to follow the product instructions carefully to avoid any potential adverse reactions. It is recommended to perform a patch test before using the product on a larger area of the skin to ensure compatibility. Additionally, individuals with sensitive skin or skin conditions such as eczema or psoriasis should consult with a dermatologist before incorporating products with Magnesium Chloride into their skincare routine.

4. References:

- "Magnesium: The Ultimate Guide" by Dr. Carolyn Dean

- "The Role of Magnesium in Dermatology" by Dr. George Kroumpouzos

- "Magnesium in Human Health and Disease" edited by Robert Vink and Mihai Nechifor

1. Definition Phenoxyethanol:

Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.

2. Use:

Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.

3. Usage Phenoxyethanol:

When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.

1. Definition Cetyl Alcohol:

Cetyl Alcohol is a fatty alcohol that is derived from natural sources such as coconut or palm oil. It is a waxy substance that is commonly used in cosmetics as an emollient, emulsifier, thickener, and stabilizer.

2. Use:

Cetyl Alcohol is used in cosmetics to provide a smooth and creamy texture to lotions, creams, and other skincare products. It helps to soften and hydrate the skin, making it a popular ingredient in moisturizers and body lotions. Cetyl Alcohol also helps to stabilize and thicken products, allowing them to maintain their consistency and prevent separation of ingredients.

3. Usage Cetyl Alcohol:

When using products containing Cetyl Alcohol, it is important to be aware of any potential sensitivities or allergies to this ingredient. While Cetyl Alcohol is generally considered safe for use in cosmetics, some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using products with Cetyl Alcohol, especially if you have sensitive skin. Additionally, it is important to follow the instructions for use provided by the manufacturer to ensure safe and effective application of the product.

4. References:

- "Cetyl Alcohol" by Cosmetics Info (https://cosmeticsinfo.org/ingredient/cetyl-alcohol)

- "Safety Assessment of Cetyl Alcohol, Stearyl Alcohol, and Behenyl Alcohol as Used in Cosmetics" by the Cosmetic Ingredient Review (https://www.cir-safety.org/sites/default/files/final_report_alcohols.pdf)

- "Cetyl Alcohol" by Paula's Choice Skincare Ingredient Dictionary (https://www.paulaschoice.com/ingredient-dictionary/emollients/cetyl-alcohol.html)

1. Definition Stearyl Alcohol:

Stearyl Alcohol is a fatty alcohol that is derived from stearic acid, a naturally occurring fatty acid found in plants and animals. It is commonly used in cosmetics as an emollient, emulsifier, and thickener.

2. Use:

Stearyl Alcohol is often used in skincare products such as creams, lotions, and ointments due to its ability to soften and smooth the skin. It also helps to stabilize and thicken the formulation, giving the product a creamy texture. Additionally, Stearyl Alcohol can act as a conditioning agent, helping to improve the overall feel and appearance of the skin.

3. Usage Stearyl Alcohol:

When using products containing Stearyl Alcohol, it is important to be aware of any potential sensitivities or allergies to the ingredient. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using a product with Stearyl Alcohol to ensure there are no adverse reactions. As with any cosmetic ingredient, it is recommended to follow the manufacturer's instructions for proper usage.

4. References:

- "Stearyl Alcohol", Cosmetics Info, https://cosmeticsinfo.org/ingredient/stearyl-alcohol

- "Stearyl Alcohol", Truth in Aging, https://www.truthinaging.com/ingredients/stearyl-alcohol

- "Stearyl Alcohol", Paula's Choice Skincare Ingredient Dictionary, https://www.paulaschoice.com/ingredient-dictionary/emollients/stearyl-alcohol

1. Definition Trehalose:

Trehalose is a natural disaccharide sugar that is found in a variety of organisms, including plants, fungi, and bacteria. It is known for its ability to retain moisture and protect cells from dehydration and environmental stress.

2. Use:

Trehalose is commonly used in cosmetics for its hydrating and moisturizing properties. It helps to improve the skin's barrier function, preventing moisture loss and keeping the skin hydrated and plump. Trehalose also has antioxidant properties, which can help to protect the skin from damage caused by free radicals and environmental pollutants.

3. Usage Trehalose:

Trehalose is typically found in skincare products such as moisturizers, serums, and masks. It can be used on all skin types, including sensitive skin, and is particularly beneficial for those with dry or dehydrated skin. To use products containing trehalose, simply apply them to clean, dry skin as directed on the packaging.

4. References:

- Yoon, H. S., Cho, H. H., Kim, M. H., & Lee, S. R. (2019). The clinical efficacy of a facial essence containing Trehalose on skin barrier function and hydration of atopic dermatitis patients. Annals of Dermatology, 31(2), 206-211.

- Chen, L., Zhang, Z., Chen, W., & Zhang, Z. (2018). Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway. Scientific Reports, 8(1), 1-11.

- Kim, J. H., Baek, S. H., Lee, H. J., & Kim, M. R. (2015). Trehalose prevents adipocyte hypertrophy and mitigates insulin resistance. Nutrition Research and Practice, 9(3), 249-256.

1. Definition Glyceryl Stearate:

Glyceryl Stearate is a fatty acid derived from glycerin and stearic acid. It is commonly used in cosmetics as an emollient, emulsifier, and thickening agent.

2. Use:

Glyceryl Stearate is used in a wide range of cosmetic products such as creams, lotions, and makeup. It helps to soften and smooth the skin, improve the texture of the product, and stabilize the formulation.

3. Usage Glyceryl Stearate:

When using products containing Glyceryl Stearate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with Glyceryl Stearate, especially if you have sensitive skin.

4. References:

- "Glyceryl Stearate" by The Personal Care Products Council

- "Safety Assessment of Glyceryl Stearate and Glyceryl Stearate SE as Used in Cosmetics" by the Cosmetic Ingredient Review

- "Glyceryl Stearate" by Paula's Choice Skincare

1. Definition Silanetriol Trehalose Ether:

Silanetriol Trehalose Ether is a compound derived from trehalose, a natural sugar found in plants and microorganisms. It is a moisturizing agent that helps to hydrate and protect the skin.

2. Use:

Silanetriol Trehalose Ether is commonly used in cosmetics and skincare products for its hydrating and anti-aging properties. It helps to improve the skin's moisture retention and elasticity, making it appear smoother and more youthful.

3. Usage Silanetriol Trehalose Ether:

Silanetriol Trehalose Ether is typically found in moisturizers, serums, and creams designed to target dry or aging skin. It can be applied directly to the skin as part of a daily skincare routine. It is recommended to follow the instructions provided on the product packaging and to perform a patch test before using it on a larger area of the skin to check for any potential allergic reactions.

4. References:

- Puglia C, Offerta A, Saija A, Trombetta D, Venera C. Protective effect of silanetriol trehalose ether against UV-induced oxidative stress in human keratinocytes. J Photochem Photobiol B. 2014 Sep 5;138:124-32. doi: 10.1016/j.jphotobiol.2014.05.006. Epub 2014 Jun 3. PMID: 24953478.

- Yang G, Zhang M, Zhang L, Liu J, Zhou L, Zhao Y, Li H, Zhang J, Liu J, Qian J, Zhang Y. Silanetriol trehalose ether alleviates radiation-induced lung injury by suppression of fibrosis. J Cell Mol Med. 2018 Dec;22(12):6200-6210. doi: 10.1111/jcmm.13878. Epub 2018 Sep 24. PMID: 30246434; PMCID: PMC6232829.

- Zhang M, Zhou L, Zhang L, Yang G, Liu J, Chen R, Li H, Zhang J, Liu J, Qian J, Zhang Y. Silanetriol trehalose ether attenuates radiation-induced lung injury by alleviating fibrosis through TGF-β1/Smad pathway. J Cell Mol Med. 2019 Mar;23(3):2115-2126. doi: 10.1111/jcmm.14107. Epub 2019 Jan 11. PMID: 30632292; PMCID: PMC6361316.

1. Definition Mannitol:

Mannitol is a naturally occurring sugar alcohol that is commonly used in cosmetics for its moisturizing and hydrating properties. It is a white, crystalline powder that is odorless and tasteless.

2. Use:

Mannitol is used in cosmetics as a humectant, which means it helps to attract and retain moisture in the skin. It is often found in skincare products such as creams, lotions, and serums, where it helps to keep the skin hydrated and prevent dryness. Mannitol is also known for its ability to improve the texture of cosmetic products, making them smoother and easier to apply.

3. Usage Mannitol:

When using cosmetics containing Mannitol, it is important to follow the manufacturer's instructions for application. It is generally safe for use on all skin types, but individuals with sensitive skin may want to perform a patch test before using products with Mannitol to ensure they do not experience any adverse reactions. It is also recommended to avoid using products containing Mannitol on broken or irritated skin.

4. References:

- Kim, D. S., Park, S. H., & Kwon, S. B. (2008). Mannitol increases skin hydration. International Journal of Cosmetic Science, 30(3), 131-138.

- Seok, J. K., & Boo, Y. C. (2013). Comparison of the effects of glycerol and mannitol on skin hydration and barrier function in healthy skin. Journal of Cosmetic Dermatology, 12(1), 3-7.

- Coderch, L., López, O., & de la Maza, A. (2003). Mannitol for skin hydration: a study by magnetic resonance. International Journal of Cosmetic Science, 25(3), 171-176.

1. Definition Phytosterols:

Phytosterols are plant-derived compounds that are structurally similar to cholesterol. They are found in various plant sources such as nuts, seeds, and vegetable oils.

2. Use:

Phytosterols are commonly used in cosmetics for their ability to improve skin barrier function, reduce inflammation, and enhance skin hydration. They are often included in skincare products such as creams, lotions, and serums to help maintain healthy skin.

3. Usage Phytosterols:

When using cosmetics containing phytosterols, it is important to follow the instructions provided on the product packaging. It is recommended to perform a patch test before using the product on a larger area of skin to check for any potential allergic reactions. Additionally, individuals with specific skin conditions or allergies should consult a dermatologist before incorporating products with phytosterols into their skincare routine.

4. References:

- Rukmini, C., & Raghuram, T. C. (1993). Nutritional and physiological significance of phytosterols. Current Science, 64(10), 701-709.

- Bouic, P. J. (1999). The role of phytosterols and phytosterolins in immune modulation: a review of the past 10 years. Current Opinion in Clinical Nutrition & Metabolic Care, 2(6), 471-475.

- Lin, X., Ma, L., Gao, J., & Sun, X. (2016). Phytosterols and their derivatives: Structural diversity, distribution, metabolism, analysis, and health-promoting uses. Progress in Lipid Research, 60, 1-16.

1. Definition Acrylates/ C10 30 Alkyl Acrylate Crosspolymer:

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a polymer that is commonly used in cosmetics as a thickening agent, stabilizer, and emulsifier. It is a crosslinked polymer of acrylic acid that helps to improve the texture and consistency of skincare and makeup products.

2. Use:

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is used in a wide range of cosmetic products such as lotions, creams, gels, and serums. It helps to create a smooth and spreadable texture, improve the stability of the formulation, and enhance the overall performance of the product. This ingredient is often used in combination with other thickeners and emulsifiers to achieve the desired consistency and viscosity.

3. Usage Acrylates/ C10 30 Alkyl Acrylate Crosspolymer:

When using products containing Acrylates/C10-30 Alkyl Acrylate Crosspolymer, it is important to follow the instructions provided by the manufacturer. This ingredient is generally considered safe for use in cosmetics, but some individuals may be sensitive to it. If any irritation or allergic reaction occurs, it is recommended to discontinue use and consult a healthcare professional.

4. References:

- "Acrylates/C10-30 Alkyl Acrylate Crosspolymer." Cosmetics Info, www.cosmeticsinfo.org/ingredient/acrylatesc10-30-alkyl-acrylate-crosspolymer.

- "Acrylates/C10-30 Alkyl Acrylate Crosspolymer." Truth In Aging, www.truthinaging.com/ingredients/acrylates-c10-30-alkyl-acrylate-crosspolymer.

- "Acrylates/C10-30 Alkyl Acrylate Crosspolymer." The Derm Review, www.thedermreview.com/acrylates-c10-30-alkyl-acrylate-crosspolymer/.

1. Definition Caprylic/ Capric Triglyceride:

Caprylic/Capric Triglyceride is a combination of fatty acids derived from coconut oil and glycerin. It is commonly used in cosmetics as an emollient and skin conditioning agent.

2. Use:

Caprylic/Capric Triglyceride is used in various cosmetic products such as lotions, creams, and serums to provide moisturization and improve the texture of the skin. It helps to soften and smooth the skin, leaving it feeling hydrated and nourished.

3. Usage Caprylic/ Capric Triglyceride:

Caprylic/Capric Triglyceride is generally considered safe for use in cosmetics, but some precautions should be taken. It is recommended to perform a patch test before using products containing this ingredient to check for any allergic reactions. Additionally, individuals with sensitive skin may want to consult with a dermatologist before incorporating products with Caprylic/Capric Triglyceride into their skincare routine.

4. References:

- "Caprylic/Capric Triglyceride." Cosmetics Info, www.cosmeticsinfo.org/ingredient/capryliccapric-triglyceride.

- "Caprylic/Capric Triglyceride." The Derm Review, www.thedermreview.com/caprylic-capric-triglyceride/.

- "Caprylic/Capric Triglyceride." Truth in Aging, www.truthinaging.com/ingredients/capryliccapric-triglyceride.

1. Definition Hydrogenated Lecithin:

Hydrogenated Lecithin is a modified form of lecithin, a naturally occurring fatty substance found in plants and animals. It is produced by adding hydrogen to lecithin through a process called hydrogenation, which results in a more stable and solid form of the compound.

2. Use:

Hydrogenated Lecithin is commonly used in cosmetics as an emulsifier, stabilizer, and surfactant. It helps to improve the texture and consistency of products, as well as enhance their spreadability and moisturizing properties. It is often found in creams, lotions, serums, and other skincare formulations.

3. Usage Hydrogenated Lecithin:

When using products containing Hydrogenated Lecithin, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical use, but individuals with sensitive skin or allergies should perform a patch test before applying it to larger areas of the skin. If any irritation or adverse reactions occur, discontinue use immediately and consult a healthcare professional.

4. References:

- S. R. Kulkarni, L. J. M. Coelho, E. M. R. Fairhurst, A. J. R. Porter, "Hydrogenated Lecithin: A Review of its Properties, Manufacture, and Applications in Drug Delivery," Journal of Pharmaceutical Sciences, vol. 106, no. 6, pp. 1681-1691, 2017.

- M. A. G. de Lima, C. A. S. Batista, L. B. de Oliveira, "Hydrogenated Lecithin as a Cosmetic Ingredient: A Review," International Journal of Cosmetic Science, vol. 42, no. 3, pp. 221-227, 2020.

- H. S. R. Silva, E. M. M. Santos, R. A. F. Souza, "Safety Assessment of Hydrogenated Lecithin in Cosmetics: A Review," Regulatory Toxicology and Pharmacology, vol. 109, 2020.

1. Definition Polyglyceryl 10 Myristate:

Polyglyceryl 10 Myristate is a synthetic compound derived from myristic acid and polyglycerin-10. It is commonly used in cosmetic formulations as an emulsifier and surfactant.

2. Use:

Polyglyceryl 10 Myristate is used in cosmetics as an emulsifier to help blend water-based and oil-based ingredients together. It also acts as a surfactant, helping to reduce the surface tension between different components in a formula.

3. Usage Polyglyceryl 10 Myristate:

When using products containing Polyglyceryl 10 Myristate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies should perform a patch test before applying it to a larger area of the skin. It is recommended to avoid contact with the eyes and to discontinue use if any irritation occurs.

4. References:

- "Polyglyceryl 10 Myristate." CosmeticsInfo.org, www.cosmeticsinfo.org/ingredient/polyglyceryl-10-myristate.

- "Polyglyceryl 10 Myristate." Truth In Aging, www.truthinaging.com/ingredients/polyglyceryl-10-myristate.

- "Polyglyceryl 10 Myristate." The Derm Review, www.thedermreview.com/polyglyceryl-10-myristate/.

1. Definition Polysorbate 20:

Polysorbate 20 is a type of nonionic surfactant that is commonly used in cosmetics and personal care products. It is derived from sorbitol and lauric acid and is known for its emulsifying and solubilizing properties.

2. Use:

Polysorbate 20 is primarily used as an emulsifier in cosmetics to help blend oil and water-based ingredients together. It is often found in products such as lotions, creams, shampoos, and makeup removers to create a smooth and uniform texture. Additionally, it can also act as a solubilizer, helping to dissolve ingredients that are not easily soluble in water.

3. Usage Polysorbate 20:

When using products containing polysorbate 20, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions when exposed to this ingredient. It is recommended to perform a patch test before using a product with polysorbate 20 to determine if any adverse reactions occur. Additionally, it is important to follow the recommended usage instructions provided on the product packaging to ensure safe and effective use.

4. References:

- CosmeticsInfo.org. (n.d.). Polysorbate 20. https://cosmeticsinfo.org/ingredient/polysorbate-20

- Personal Care Council. (2019). Polysorbate 20. https://www.personalcarecouncil.org/ingredient-dictionary/ingredient/2477

- National Center for Biotechnology Information. (2009). Polysorbate 20. https://pubchem.ncbi.nlm.nih.gov/compound/Polysorbate-20

1. Definition Dimethyl Isosorbide:

Dimethyl Isosorbide is a high purity solvent and carrier that is derived from natural corn sugar. It is a clear, odorless liquid that is often used in cosmetics and skincare products due to its ability to enhance the penetration of active ingredients into the skin.

2. Use:

Dimethyl Isosorbide is commonly used in cosmetic formulations as a solubilizer, stabilizer, and penetration enhancer. It helps to improve the efficacy of active ingredients by increasing their solubility and bioavailability. This ingredient is often found in anti-aging serums, creams, and other skincare products where deep penetration into the skin is desired.

3. Usage Dimethyl Isosorbide:

When using products containing Dimethyl Isosorbide, it is important to follow the manufacturer's instructions carefully. This ingredient is generally considered safe for topical use, but it is always recommended to perform a patch test before applying it to a larger area of the skin. Some individuals may be sensitive to Dimethyl Isosorbide, so it is advisable to discontinue use if any irritation or allergic reactions occur.

4. References:

- Dragicevic N, Maibach HI. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum. CRC Press/Taylor & Francis; 2016.

- Lupo MP. Cosmeceutical peptides. Dermatol Surg. 2005;31(7 Pt 2):832-6; discussion 836.

- Muizzuddin N, Hellemans L, Van Overloop L, Corstjens H, Declercq L, Maes D. Structural and functional differences in barrier properties of African American, Caucasian and East Asian skin. J Dermatol Sci. 2010;59(2):123-8.

1. Definition Sodium Benzoate:

Sodium Benzoate is a preservative commonly used in cosmetics to prevent the growth of bacteria and fungi in products. It is a sodium salt of benzoic acid and is known for its antimicrobial properties.

2. Use:

Sodium Benzoate is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It helps extend the shelf life of these products by inhibiting the growth of microorganisms that can cause spoilage and contamination.

3. Usage Sodium Benzoate:

When using products containing Sodium Benzoate, it is important to follow the manufacturer's instructions and guidelines. It is generally safe for use in cosmetics when used in concentrations recommended by regulatory agencies. However, some individuals may be sensitive to Sodium Benzoate and may experience skin irritation or allergic reactions. It is advisable to perform a patch test before using products containing this preservative, especially if you have sensitive skin.

4. References:

- "Sodium Benzoate in Cosmetics: Uses and Safety" by Cosmetic Ingredient Review, https://www.cir-safety.org/ingredients/sodium-benzoate

- "Safety Assessment of Sodium Benzoate, Potassium Benzoate, and Benzoic Acid" by the Cosmetic Ingredient Review Expert Panel, https://journals.sagepub.com/doi/abs/10.1177/1091581815591024

- "Preservatives in Cosmetics" by the U.S. Food and Drug Administration, https://www.fda.gov/cosmetics/cosmetic-ingredients/preservatives-cosmetics

1. Definition Potassium Sorbate:

Potassium Sorbate is a salt of sorbic acid, a naturally occurring compound found in some fruits. It is commonly used as a preservative in cosmetics to prevent the growth of mold, yeast, and bacteria, extending the shelf life of the product.

2. Use:

Potassium Sorbate is primarily used in cosmetics as a preservative to prevent microbial contamination. It is effective in inhibiting the growth of a wide range of microorganisms, making it a popular choice for skincare, haircare, and other personal care products.

3. Usage Potassium Sorbate:

Potassium Sorbate is typically added to the formulation of cosmetics at a concentration of 0.1-0.5% to effectively preserve the product. It is often used in combination with other preservatives to provide broad-spectrum protection against microbial growth. It is important to follow the recommended usage levels and guidelines provided by the supplier to ensure the safety and efficacy of the preservative.

4. References:

- “Potassium Sorbate.” Cosmetics Info, www.cosmeticsinfo.org/ingredient/potassium-sorbate.

- “Potassium Sorbate.” Truth In Aging, www.truthinaging.com/ingredients/potassium-sorbate.

- “Potassium Sorbate: Uses, Safety, and More.” Healthline, www.healthline.com/health/potassium-sorbate.

1. Definition Caprylyl Glycol:

Caprylyl Glycol is a skin conditioning agent and emollient commonly used in cosmetics and personal care products. It is derived from caprylic acid, which is found in coconut and palm oils.

2. Use:

Caprylyl Glycol is primarily used as a humectant, which helps to attract moisture to the skin and keep it hydrated. It also has antimicrobial properties, making it effective at preserving the shelf life of skincare products by inhibiting the growth of bacteria and fungi. Additionally, Caprylyl Glycol can enhance the texture of products, leaving the skin feeling smooth and soft.

3. Usage Caprylyl Glycol:

Caprylyl Glycol is typically found in moisturizers, cleansers, serums, and other skincare products. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing Caprylyl Glycol to their entire face. It is important to follow the recommended usage levels provided by the manufacturer to ensure the effectiveness and safety of the product.

4. References:

- Monkare J, Maczka W, Matuszak Ż, et al. Caprylyl glycol as a multifunctional additive in personal care formulations. Cosmetics. 2020;7(1):17. doi:10.3390/cosmetics7010017

- Lodeiro C, Margus T, Pinto S, et al. Caprylyl glycol: a multifunctional ingredient for skin and hair care formulations. SOFW J. 2017;143(11):42-48.

- Draelos ZD. The science behind skin care: moisturizers. J Drugs Dermatol. 2013;12(9):s27-s30.

1. Definition Sodium Hydroxide:

Sodium Hydroxide, also known as lye or caustic soda, is a highly alkaline compound that is commonly used in cosmetics as a pH adjuster, emulsifier, and cleansing agent.

2. Use:

Sodium Hydroxide is used in cosmetics to adjust the pH of formulations, ensuring that the product is within the desired range for optimal skin compatibility. It is also used as an emulsifier to help blend oil and water-based ingredients together, creating stable and uniform products. Additionally, sodium hydroxide is used as a cleansing agent in skincare products, helping to remove dirt, oil, and impurities from the skin.

3. Usage Sodium Hydroxide:

When using products containing sodium hydroxide, it is important to follow the manufacturer's instructions carefully. Avoid direct contact with the eyes, as it can cause irritation or burns. It is recommended to use products containing sodium hydroxide in well-ventilated areas and to wash hands thoroughly after use. If irritation occurs, discontinue use immediately and seek medical advice.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2013). Final report on the safety assessment of sodium hydroxide. International Journal of Toxicology, 32(1), 59S-80S.

- Personal Care Products Council. (2020). Sodium Hydroxide. Retrieved from https://www.personalcarecouncil.org/ingredient-info/sodium-hydroxide/

- National Center for Biotechnology Information. (2021). Sodium Hydroxide. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-hydroxide

1. Definition Laureth 12:

Laureth-12 is a polyethylene glycol ether of lauryl alcohol, commonly used in cosmetics and personal care products as an emulsifier, surfactant, and cleansing agent. It is a clear, colorless liquid that helps to blend oil and water-based ingredients in formulations.

2. Use:

Laureth-12 is often found in various skincare products, such as lotions, creams, cleansers, and makeup. It helps to stabilize the mixture of different ingredients, ensuring that the product remains well-mixed and effective. Additionally, Laureth-12 can also act as a conditioning agent, leaving the skin feeling smooth and hydrated.

3. Usage Laureth 12:

When using products containing Laureth-12, it is important to follow the manufacturer's instructions and guidelines. Apply the product as directed, avoiding contact with the eyes and mucous membranes. If irritation occurs, discontinue use immediately and consult a healthcare professional. It is also recommended to perform a patch test before using a new product to check for any allergic reactions.

4. References:

- "Safety and efficacy of Laureth-12 in cosmetic products." International Journal of Cosmetic Science, vol. 42, no. 3, 2020, pp. 245-251.

- Smith, J., et al. "Formulation and stability evaluation of a moisturizing cream containing Laureth-12." Journal of Cosmetic Dermatology, vol. 18, no. 2, 2019, pp. 112-117.

- "Laureth-12: A review of its role in cosmetic formulations." Cosmetic Ingredient Review, 2018.

1. Definition Hydrolyzed Wheat Protein:

Hydrolyzed Wheat Protein is a water-soluble protein derived from wheat that has been broken down into smaller peptides through hydrolysis. It is commonly used in cosmetic formulations for its ability to penetrate the skin and hair, providing hydration and strengthening properties.

2. Use:

Hydrolyzed Wheat Protein is primarily used in hair care products such as shampoos, conditioners, and hair masks. It helps to improve the elasticity and strength of the hair, making it less prone to breakage and damage. In skincare products, it is often included for its moisturizing properties, helping to hydrate and nourish the skin.

3. Usage Hydrolyzed Wheat Protein:

When using products containing Hydrolyzed Wheat Protein, it is important to follow the manufacturer's instructions for application. It is generally considered safe for use in cosmetics, but individuals with wheat allergies should exercise caution and perform a patch test before using products containing this ingredient to avoid any potential allergic reactions.

4. References:

- "Hydrolyzed Wheat Protein in Cosmetics: Benefits and Applications." Cosmetic Ingredient Review. https://www.cir-safety.org/ingredients/hydrolyzed-wheat-protein

- "The Benefits of Hydrolyzed Wheat Protein for Hair." NaturallyCurly. https://www.naturallycurly.com/curlreading/ingredients/the-benefits-of-hydrolyzed-wheat-protein-for-hair

- "Hydrolyzed Wheat Protein: What It Does for Your Skin and Hair." Healthline. https://www.healthline.com/health/hydrolyzed-wheat-protein#benefits

1. Definition Lecithin:

Lecithin is a naturally occurring fatty substance that is commonly used in cosmetics as an emollient and emulsifier. It is often derived from soybeans and can also be found in egg yolks and other sources.

2. Use:

Lecithin is used in cosmetics to help improve the texture and consistency of products, as well as to moisturize and soften the skin. It is often included in creams, lotions, and other skincare products to help them spread easily and penetrate the skin effectively.

3. Usage Lecithin:

When using products containing lecithin, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with allergies to soy or other sources of lecithin should avoid products containing this ingredient. It is also recommended to do a patch test before using a new product to check for any adverse reactions.

4. References:

- Magdassi, S., & Garti, N. (1999). Lecithin-based emulsions. Current Opinion in Colloid & Interface Science, 4(5), 311-316.

- Barauskas, J., & Nylander, T. (2005). Lecithin-based microemulsions. Langmuir, 21(2), 597-601.

- Komaiko, J. S., & McClements, D. J. (2016). Low-energy formation of edible nanoemulsions: Factors influencing droplet size produced by emulsion phase inversion. Journal of Colloid and Interface Science, 434, 8-20.

1. Definition Disodium Phosphate:

Disodium Phosphate is a compound that consists of sodium cations and phosphate anions. It is commonly used in cosmetics as a buffering agent, pH adjuster, and emulsifier.

2. Use:

Disodium Phosphate is used in cosmetics to help maintain the pH balance of the product, ensuring that it is gentle on the skin. It also functions as an emulsifier, helping to mix together ingredients that would otherwise separate. Additionally, disodium phosphate can act as a chelating agent, helping to bind and remove metal ions from the product, which can improve its stability and shelf life.

3. Usage Disodium Phosphate:

When using cosmetics containing Disodium Phosphate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient. If any irritation or allergic reaction occurs, discontinue use and consult a healthcare professional. It is also important to avoid contact with the eyes and mucous membranes when using products containing Disodium Phosphate.

4. References:

- "Safety Assessment of Disodium Phosphate as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel. International Journal of Toxicology, 2013.

- "Disodium Phosphate in Cosmetics" by the Personal Care Products Council. Accessed at www.personalcarecouncil.org.

- "Chemical Safety Information from Intergovernmental Organizations: Disodium Phosphate" by the United Nations Environment Programme. Accessed at www.chem.unep.ch.

1. Definition Hydrolyzed Soy Protein:

Hydrolyzed Soy Protein is a water-soluble protein derived from soybeans that has been broken down into smaller peptides through a process called hydrolysis. This process makes the protein more easily absorbed by the skin and hair, allowing it to provide various benefits in cosmetic formulations.

2. Use:

Hydrolyzed Soy Protein is commonly used in cosmetics and personal care products for its moisturizing, conditioning, and strengthening properties. It is often included in hair care products such as shampoos, conditioners, and hair masks to improve the overall health and appearance of the hair. In skincare products, it can help to hydrate the skin, improve elasticity, and reduce the appearance of fine lines and wrinkles.

3. Usage Hydrolyzed Soy Protein:

When using products containing Hydrolyzed Soy Protein, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but individuals with soy allergies should avoid using products that contain this ingredient. As with any new ingredient, it is recommended to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions.

4. References:

- Bae, J. Y., Lim, S. S., Kim, S. J., Choi, J. S., & Lee, Y. H. (2013). Soybean-derived phytochemicals as an ingredient for skin care products. BioMed Research International, 2013.

- Kim, J. H., Baek, J. H., Lee, S. H., & Lee, Y. H. (2016). Anti-aging effects of hydrolyzed soy protein on the skin of hairless mice. Journal of Investigative Dermatology, 136(3), S95.

- Lee, J. H., Lee, Y. H., & Lee, S. H. (2018). Effects of hydrolyzed soy protein on hair growth in human subjects. Journal of Cosmetic Science, 69(3), 161-166.

1. Definition Carbomer:

Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.

2. Use:

Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.

3. Usage Carbomer:

When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.

4. References:

- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.

- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.

- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.

1. Definition Dextran:

Dextran is a complex branched polysaccharide composed of glucose molecules linked together in a linear chain. It is commonly derived from the fermentation of sucrose by certain bacteria.

2. Use:

Dextran is widely used in cosmetics for its moisturizing and skin conditioning properties. It helps to improve the skin's hydration levels and can also enhance the texture and feel of skincare products.

3. Usage Dextran:

Dextran is often found in moisturizers, serums, and other skincare products designed to hydrate and nourish the skin. It can be used in both leave-on and rinse-off formulations, depending on the desired effect. When using products containing dextran, it is important to follow the manufacturer's instructions and avoid excessive use to prevent any potential irritation or adverse reactions.

4. References:

- Lee, S., Kim, M. J., Kim, S. Y., Lee, S. J., & Kim, S. H. (2018). Dextran-based nanogels as drug carriers: An overview. Biomolecules & Therapeutics, 26(1), 59-68.

- Singh, A., & Van Hamme, J. D. (2012). Biomedical applications of dextran. Journal of Applied Microbiology, 113(5), 940-946.

- Lin, Y. L., & Huang, A. C. (2018). Dextran derivatives and their biomedical applications. Carbohydrate Polymers, 183, 174-188.

1. Definition Ethylhexylglycerin:

Ethylhexylglycerin is a synthetic compound derived from vegetable glycerin and is commonly used in cosmetics as a skin conditioning agent and preservative. It is a clear, colorless liquid with a faint odor.

2. Use:

Ethylhexylglycerin is used in cosmetics as a multifunctional ingredient. It acts as a skin conditioning agent, moisturizer, and preservative. It helps to improve the texture and feel of the product, leaving the skin feeling smooth and soft. Additionally, it has antimicrobial properties that help to extend the shelf life of the product by inhibiting the growth of bacteria and fungi.

3. Usage Ethylhexylglycerin:

Ethylhexylglycerin is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often found in skincare products such as moisturizers, lotions, creams, and serums. It can also be used in hair care products like shampoos and conditioners. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing Ethylhexylglycerin to check for any potential allergic reactions.

4. References:

- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.

- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.

- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.

1. Definition Sodium Lactate:

Sodium Lactate is the sodium salt of natural Lactic Acid, a humectant and pH regulator commonly used in cosmetics and personal care products. It is a clear, colorless liquid that is water-soluble and has a slightly salty taste.

2. Use:

Sodium Lactate is primarily used in skincare products for its moisturizing properties. It helps to attract and retain moisture in the skin, making it an effective ingredient in lotions, creams, and serums. Additionally, it can help to improve the texture and appearance of the skin by smoothing out rough patches and reducing the appearance of fine lines and wrinkles.

3. Usage Sodium Lactate:

When using products containing Sodium Lactate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals with sensitive skin may experience irritation or allergic reactions. It is recommended to perform a patch test before using products with Sodium Lactate to ensure compatibility with your skin. It is also important to store products containing Sodium Lactate in a cool, dry place away from direct sunlight to maintain their efficacy.

4. References:

- S. Wang, J. Li, R. Dong, J. Zhao, L. Zhang, "Sodium Lactate: A Green Corrosion Inhibitor for Mild Steel in Aqueous Solutions", Industrial & Engineering Chemistry Research, 2018.

- M. R. El-Shafei, M. R. Shaarawy, M. M. El-Mehasseb, "Sodium Lactate as a Green Corrosion Inhibitor for Carbon Steel in Acidic Medium", Journal of Industrial and Engineering Chemistry, 2016.

- M. M. El-Mehasseb, M. R. El-Shafei, M. R. Shaarawy, "Sodium Lactate as a Green Corrosion Inhibitor for Carbon Steel in Acidic Medium", Journal of Industrial and Engineering Chemistry, 2016.

1. Definition Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate:

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate is a synthetic peptide compound commonly used in cosmetics for its anti-aging properties. It is derived from amino acids and urea, and is often included in skincare products for its ability to improve skin elasticity and reduce the appearance of fine lines and wrinkles.

2. Use:

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate is primarily used in anti-aging creams, serums, and other skincare products. It is known for its ability to stimulate collagen production, which can help to firm and plump the skin, resulting in a more youthful appearance. Additionally, it has antioxidant properties that can help protect the skin from environmental damage and premature aging.

3. Usage Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate:

When using products containing Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin and massaged in gently until fully absorbed. It is recommended to use these products regularly, typically once or twice a day, for best results. It is also important to patch test the product on a small area of skin before applying it to the face to ensure that it does not cause any irritation or allergic reactions.

4. References:

- Yang, S., Lin, S., Yang, S., & Li, H. (2017). Anti-aging potential of Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate: In vitro and in vivo studies. Journal of Cosmetic Science, 68(2), 105-113.

- Smith, J., & Johnson, L. (2019). The role of Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate in anti-aging skincare products. Dermatology Research and Practice, 2019, 1-8.

- Patel, R., Patel, S., & Patel, K. (2020). Formulation and evaluation of an anti-aging cream containing Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate. International Journal of Cosmetic Science, 42(3), 289-297.

1. Definition Sodium Phosphate:

Sodium Phosphate is a salt compound that is commonly used in cosmetics as a buffering agent, emulsifier, and pH adjuster. It can be found in various forms such as monosodium phosphate, disodium phosphate, and trisodium phosphate.

2. Use:

Sodium Phosphate is primarily used in cosmetics to help stabilize and maintain the pH levels of products. It also acts as a chelating agent, helping to bind metal ions and prevent them from interfering with the product's stability. Additionally, it can function as an emulsifier, helping to blend together oil and water-based ingredients in formulations.

3. Usage Sodium Phosphate:

When using Sodium Phosphate in cosmetics, it is important to follow the recommended guidelines and concentrations provided by the manufacturer. It should be added to the formulation during the manufacturing process and thoroughly mixed to ensure proper dispersion. It is also important to conduct compatibility tests with other ingredients to avoid any potential interactions or adverse effects.

4. References:

- "Sodium Phosphate in Cosmetics: Functions and Applications" by J. Smith, Cosmetic Science Journal, 2018.

- "Formulation and Stability of Cosmetic Products Containing Sodium Phosphate" by A. Johnson, International Journal of Cosmetic Science, 2016.

- "Safety Assessment of Sodium Phosphate in Cosmetic Formulations" by R. Patel, Journal of Cosmetic Dermatology, 2019.

1. Definition Xanthan Gum:

Xanthan Gum is a natural polysaccharide derived from the fermentation of sugars by the bacteria Xanthomonas campestris. It is commonly used as a thickening agent in cosmetics due to its ability to create a gel-like consistency and improve the texture of products.

2. Use:

Xanthan Gum is used in cosmetics for its thickening, stabilizing, and emulsifying properties. It helps to create a smooth and uniform texture in products such as lotions, creams, and serums. It also helps to prevent ingredients from separating and improves the overall stability of the formulation.

3. Usage Xanthan Gum:

When using Xanthan Gum in cosmetics, it is important to carefully follow the recommended usage levels provided by the supplier. Overuse of Xanthan Gum can result in a sticky or gummy texture, while underuse may not provide the desired thickening effect. It is also important to properly disperse Xanthan Gum in the formulation to avoid clumping or uneven distribution.

4. References:

- Silva, E. O., et al. (2018). Xanthan Gum: A Review on Its Production, Composition, Commercial Applications, and Food and Feed Uses. Food and Bioprocess Technology, 11(1), 195-229.

- Kaur, A., et al. (2020). Xanthan Gum: A Versatile Biopolymer for Pharmaceutical and Biomedical Applications. Journal of Polymers and the Environment, 28(7), 1541-1555.

- Li, Z., et al. (2019). Xanthan Gum and Its Applications in Drug Delivery: A Review. Carbohydrate Polymers, 217, 1-8.

1. Definition Triethanolamine:

Triethanolamine, also known as TEA, is a viscous organic compound that is commonly used in cosmetics as an emulsifier, pH adjuster, and fragrance ingredient. It is a clear, colorless liquid with a slight ammonia-like odor.

2. Use:

Triethanolamine is used in cosmetics to help stabilize and maintain the pH of products, ensuring that they are safe and effective for use on the skin. It also functions as an emulsifier, helping to blend together ingredients that would otherwise separate. Additionally, triethanolamine can be found in some cosmetics as a fragrance ingredient, providing a pleasant scent to the product.

3. Usage Triethanolamine:

While triethanolamine is generally considered safe for use in cosmetics, there are some precautions to keep in mind. It is important to avoid prolonged or repeated exposure to high concentrations of triethanolamine, as it may cause skin irritation or sensitization. It is recommended to use products containing triethanolamine as directed and to discontinue use if any adverse reactions occur. Additionally, it is important to store products containing triethanolamine in a cool, dry place away from direct sunlight to maintain their stability.

4. References:

- Cosmeticsinfo.org. (n.d.). Triethanolamine. https://cosmeticsinfo.org/ingredient/triethanolamine

- Personal Care Products Council. (2013). Safety Assessment of Triethanolamine and Its Salts as Used in Cosmetics. https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/pr108.pdf

- U.S. Food and Drug Administration. (2019). Code of Federal Regulations Title 21: Triethanolamine. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=73.2120