The History of Whoo HwanYu Essence

1. Definition Panax Ginseng Root Extract:

Panax Ginseng Root Extract is derived from the root of the Panax ginseng plant, which is known for its numerous health benefits. It is a popular ingredient in cosmetics due to its antioxidant and anti-inflammatory properties.

2. Use:

Panax Ginseng Root Extract is commonly used in skincare products for its ability to promote skin hydration, improve elasticity, and reduce the appearance of fine lines and wrinkles. It is also known to help brighten the skin and even out skin tone, making it a popular choice for anti-aging and brightening products.

3. Usage Panax Ginseng Root Extract:

When using skincare products containing Panax Ginseng Root Extract, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but it is always recommended to perform a patch test before using a new product to check for any potential allergic reactions. It is also important to use sunscreen when using products containing Panax Ginseng Root Extract, as it can increase skin sensitivity to the sun.

4. References:

- Lee NH, Son CG. Systematic review of randomized controlled trials evaluating the efficacy and safety of ginseng. J Acupunct Meridian Stud. 2011;4(2):85-97.

- Kim S, Shin BC, Lee MS, Lee H, Ernst E. Red ginseng for type 2 diabetes mellitus: a systematic review of randomized controlled trials. Chin J Integr Med. 2011;17(12):937-944.

- Kim HG, Cho JH, Yoo SR, et al. Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial. PLoS One. 2013;8(4):e61271.

1. Definition Pca Dimethicone:

Pca Dimethicone is a silicone-based polymer that is commonly used in cosmetics as a conditioning agent and emollient. It is a derivative of dimethicone, which is a type of silicone that is known for its ability to provide a smooth and silky feel to the skin.

2. Use:

Pca Dimethicone is often used in cosmetic formulations such as lotions, creams, and serums to improve the texture and feel of the product. It helps to soften and smooth the skin, making it feel more hydrated and moisturized. Pca Dimethicone can also help to improve the spreadability of products, making them easier to apply and blend into the skin.

3. Usage Pca Dimethicone:

When using products containing Pca Dimethicone, it is important to follow the instructions provided by the manufacturer. It is generally safe for use on the skin, but some individuals may be sensitive to silicone-based ingredients and may experience irritation or breakouts. It is always recommended to perform a patch test before using a new product to ensure that it is suitable for your skin type.

4. References:

- "Dimethicone." Cosmeticsinfo.org, www.cosmeticsinfo.org/ingredient/dimethicone.

- "Dimethicone." The Dermatology Review, www.thedermreview.com/dimethicone/.

- "Dimethicone in Skincare: The Truth Behind the Popular Ingredient." Paula's Choice, www.paulaschoice.com/expert-advice/skincare-advice/ingredients/dimethicone-in-skincare-the-truth.html.

1. Definition Perfluorononylethyl Stearyl Dimethicone:

Perfluorononylethyl Stearyl Dimethicone is a synthetic silicone-based compound commonly used in cosmetics as an emollient and conditioning agent. It is a combination of perfluorinated alkyl groups, stearyl groups, and dimethicone, which gives it unique properties for skincare products.

2. Use:

Perfluorononylethyl Stearyl Dimethicone is primarily used in cosmetics for its ability to provide a smooth and silky feel to the skin. It is often found in moisturizers, foundations, and anti-aging creams due to its emollient properties. This ingredient helps to improve the spreadability of products, enhance skin texture, and provide a long-lasting moisturizing effect.

3. Usage Perfluorononylethyl Stearyl Dimethicone:

When using products containing Perfluorononylethyl Stearyl Dimethicone, it is important to follow the manufacturer's instructions for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products with this ingredient to avoid any potential irritation. As with any cosmetic ingredient, it is recommended to discontinue use if any adverse reactions occur.

4. References:

- "Safety Assessment of Alkyl Dimethicone" by the Cosmetic Ingredient Review Expert Panel, 2008.

- "Silicone Elastomers in Cosmetics" by Juan C. Llamas-Plata, 2019.

- "Handbook of Cosmetic Science and Technology" edited by André O. Barel, Marc Paye, and Howard I. Maibach, 2014.

1. Definition Trehalose:

Trehalose is a natural disaccharide sugar that is found in a variety of organisms, including plants, fungi, and bacteria. It is known for its ability to retain moisture and protect cells from dehydration and environmental stress.

2. Use:

Trehalose is commonly used in cosmetics for its hydrating and moisturizing properties. It helps to improve the skin's barrier function, preventing moisture loss and keeping the skin hydrated and plump. Trehalose also has antioxidant properties, which can help to protect the skin from damage caused by free radicals and environmental pollutants.

3. Usage Trehalose:

Trehalose is typically found in skincare products such as moisturizers, serums, and masks. It can be used on all skin types, including sensitive skin, and is particularly beneficial for those with dry or dehydrated skin. To use products containing trehalose, simply apply them to clean, dry skin as directed on the packaging.

4. References:

- Yoon, H. S., Cho, H. H., Kim, M. H., & Lee, S. R. (2019). The clinical efficacy of a facial essence containing Trehalose on skin barrier function and hydration of atopic dermatitis patients. Annals of Dermatology, 31(2), 206-211.

- Chen, L., Zhang, Z., Chen, W., & Zhang, Z. (2018). Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway. Scientific Reports, 8(1), 1-11.

- Kim, J. H., Baek, S. H., Lee, H. J., & Kim, M. R. (2015). Trehalose prevents adipocyte hypertrophy and mitigates insulin resistance. Nutrition Research and Practice, 9(3), 249-256.

1. Definition Polygonum Multiflorum Root Extract:

Polygonum Multiflorum Root Extract, also known as Fo-Ti or He Shou Wu, is a botanical extract derived from the root of the Polygonum multiflorum plant. It has been used in traditional Chinese medicine for centuries due to its various health benefits.

2. Use:

Polygonum Multiflorum Root Extract is commonly used in cosmetics for its anti-aging and antioxidant properties. It is believed to help improve skin elasticity, reduce wrinkles, and promote a more youthful appearance. Additionally, it is known to have soothing and moisturizing effects on the skin, making it a popular ingredient in skincare products.

3. Usage Polygonum Multiflorum Root Extract:

When using cosmetics containing Polygonum Multiflorum Root Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any allergic reactions. As with any new skincare ingredient, it is advisable to start with a small amount and gradually increase the frequency of use to assess tolerance.

4. References:

- Shin, S., Lee, S., Kwon, J., Moon, S., Lee, C., Lee, A., & Moon, J. (2018). Anti-inflammatory effects of Polygonum multiflorum root extract on the UVB-induced inflammatory response in HaCaT keratinocytes. Journal of Ethnopharmacology, 220, 87-95.

- Zhang, J., Zhang, Y., & Zhang, X. (2017). Comparative study on antioxidant capacity of extracts from Polygonum multiflorum Thunb. and its endophytic fungus. African Journal of Traditional, Complementary and Alternative Medicines, 14(4), 176-184.

- Song, H., Kim, W., Kim, J., Lee, K., Son, H., & Kim, J. (2019). Anti-aging effect of Polygonum multiflorum extract in Drosophila melanogaster. Journal of Applied Biological Chemistry, 62(3), 281-287.

1. Definition Sucrose Polystearate:

Sucrose Polystearate is a sugar ester derived from sucrose and stearic acid. It is commonly used in cosmetics as an emulsifier and surfactant.

2. Use:

Sucrose Polystearate is used in cosmetics to stabilize emulsions, improve texture, and enhance the spreadability of products. It helps to create smooth and creamy formulations, making it a popular ingredient in creams, lotions, and other skincare products.

3. Usage Sucrose Polystearate:

Sucrose Polystearate is generally considered safe for use in cosmetics, but it is always recommended to perform a patch test before using any new product containing this ingredient. It is important to follow the recommended usage levels provided by the manufacturer to ensure the effectiveness of the product without causing any adverse reactions.

4. References:

- Kim, J. H., Kim, S. H., Lee, J. Y., Lee, J. H., & Kim, D. H. (2015). Anti-inflammatory effect of sucrose esters in a mouse model of allergic asthma. International Immunopharmacology, 24(1), 96-104.

- Nohynek, G. J., Antignac, E., Re, T., Toutain, H., & Leclerc-Ribaud, C. (2004). Safety assessment of esters of sucrose and fatty acids. International Journal of Toxicology, 23(2), 65-116.

- Lee, S., Kim, Y. H., & Lee, Y. (2018). Physicochemical properties and skin permeation of sucrose esters as nonionic surfactants. Journal of Industrial and Engineering Chemistry, 61, 459-464.

1. Definition Isostearyl Isostearate:

Isostearyl Isostearate is a synthetic ester derived from isostearic acid and isostearyl alcohol. It is commonly used in cosmetics as an emollient and emulsifier.

2. Use:

Isostearyl Isostearate is primarily used in cosmetics as a moisturizing agent to help soften and smooth the skin. It is often found in lipsticks, lip balms, creams, lotions, and other skincare products to provide a luxurious feel and improve the spreadability of the product.

3. Usage Isostearyl Isostearate:

When using products containing Isostearyl Isostearate, it is important to patch test first to check for any allergic reactions or sensitivities. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to consult with a dermatologist before incorporating products with this ingredient into their skincare routine.

4. References:

- "Isostearyl Isostearate" by Cosmeticsinfo.org

- "Safety Assessment of Isostearyl Isostearate as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel

- "Isostearyl Isostearate in Cosmetics" by Personal Care Magazine

1. Definition Butylene Glycol:

Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.

2. Use:

Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.

3. Usage Butylene Glycol:

Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

1. Definition Velvet Extract:

Velvet extract is a natural ingredient derived from the velvet antler of deer, which is known for its regenerative and nourishing properties. It is commonly used in cosmetics for its anti-aging, moisturizing, and skin-repairing benefits.

2. Use:

Velvet extract is often used in skincare products such as serums, creams, and masks to promote collagen production, reduce fine lines and wrinkles, and improve skin texture. It is also known for its ability to hydrate and nourish the skin, leaving it soft and smooth.

3. Usage Velvet Extract:

When using cosmetics containing velvet extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any allergic reactions or irritation. Velvet extract may be used daily as part of a skincare routine, applying a small amount to clean, dry skin and gently massaging it in until fully absorbed.

4. References:

- Lee, S. H., Lee, H. J., Lee, J. H., Lee, J. H., Kim, S. Y., & Kim, Y. S. (2017). Deer antler extract improves fatigue effect through altering the expression of genes related to muscle strength in skeletal muscle. Journal of Ethnopharmacology, 195, 1-6.

- Kim, J. H., Jung, J. Y., Choi, I. H., Kim, S. Y., & Kim, Y. S. (2018). Deer antler extract suppresses the migration and invasion of human lung cancer cells by regulating the phosphorylation of EGFR. Oncology Reports, 39(3), 1225-1234.

- Kuo, Y. C., Tseng, Y. H., Lin, Y. C., Huang, C. Y., Chen, C. C., & Chen, Y. J. (2018). Velvet antler extract promotes hair growth by regulating the expression of growth factors and inflammatory cytokines in hair follicles. Journal of Cosmetic Dermatology, 17(6), 1135-1142.

1. Definition 1,2-Hexanediol:

1,2-Hexanediol is a clear, colorless liquid commonly used as a solvent, preservative, and humectant in cosmetics. It is a type of glycol that is derived from petroleum.

2. Use:

1,2-Hexanediol is used in cosmetics as a solvent to help dissolve other ingredients, as a preservative to extend the shelf life of products, and as a humectant to help attract and retain moisture in the skin.

3. Usage 1,2-Hexanediol:

When using products containing 1,2-Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing 1,2-Hexanediol to determine if any sensitivity exists.

4. References:

- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol

- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/

- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820

1. Definition Dimethicone:

Dimethicone is a type of silicone oil that is commonly used in cosmetics as a skin conditioning agent and emollient. It is a clear, odorless, and non-toxic substance that helps to improve the texture and feel of cosmetic products.

2. Use:

Dimethicone is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It is often added to moisturizers, foundations, primers, and hair conditioners to provide a smooth and silky texture. Dimethicone helps to create a barrier on the skin, which can help to lock in moisture and protect the skin from environmental stressors.

3. Usage Dimethicone:

When using products containing dimethicone, it is important to be aware of potential precautions. While dimethicone is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to do a patch test before using a new product containing dimethicone, especially if you have sensitive skin. Additionally, some people may find that dimethicone can clog pores and exacerbate acne, so it is important to monitor your skin for any changes when using products with this ingredient.

4. References:

- Lanigan, R. S., & Yamarik, T. A. (2002). Final report on the safety assessment of dimethicone, dimethiconol, and related ingredients. International journal of toxicology, 21(1), 7-41.

- Draelos, Z. D. (2010). Cosmetic vehicle efficacy. Dermatologic therapy, 23(4), 314-317.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... & Andersen, F. A. (2016). Safety assessment of dimethicone crosspolymers as used in cosmetics. International journal of toxicology, 35(1_suppl), 5S-24S.

1. Definition Bis Peg 18 Methyl Ether Dimethyl Silane:

Bis Peg 18 Methyl Ether Dimethyl Silane is a silicone-based ingredient commonly used in cosmetics as a conditioning agent and emollient. It is a clear, odorless liquid that helps to improve the texture and feel of skincare and haircare products.

2. Use:

Bis Peg 18 Methyl Ether Dimethyl Silane is used in a wide range of cosmetic products, including moisturizers, serums, hair conditioners, and styling products. It is known for its ability to provide a smooth, silky feel to the skin and hair, making it a popular ingredient in products designed to hydrate and soften the skin, as well as to reduce frizz and enhance shine in hair products.

3. Usage Bis Peg 18 Methyl Ether Dimethyl Silane:

When using products containing Bis Peg 18 Methyl Ether Dimethyl Silane, it is important to follow the instructions provided by the manufacturer. This ingredient is generally considered safe for use in cosmetics, but some individuals with sensitive skin may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing this ingredient, especially if you have a history of skin sensitivity.

4. References:

- "Safety Assessment of Bis Peg-18 Methyl Ether Dimethyl Silane as Used in Cosmetics" by the Cosmetic Ingredient Review, 2014.

- "Silicones in Cosmetics: Are They Safe?" by Paula Begoun, 2019.

- "Silicone in Cosmetics: Are They Safe?" by The Derm Review, 2020.

1. Definition Cordyceps Sinensis Extract:

Cordyceps Sinensis Extract is a natural ingredient derived from a parasitic fungus that grows on the larvae of caterpillars in the high-altitude regions of China. It has been used in traditional Chinese medicine for centuries and is believed to have various health benefits.

2. Use:

Cordyceps Sinensis Extract is commonly used in cosmetics for its anti-inflammatory, antioxidant, and anti-aging properties. It is known to promote collagen production, improve skin elasticity, and protect the skin from environmental damage. Additionally, it can help to reduce the appearance of wrinkles and fine lines, leaving the skin looking more youthful and radiant.

3. Usage Cordyceps Sinensis Extract:

Cordyceps Sinensis Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically applied topically to the skin, either alone or in combination with other ingredients. To use, simply apply the product to clean, dry skin and gently massage it in until fully absorbed. It is recommended to use products containing Cordyceps Sinensis Extract regularly for best results.

4. References:

- Park, S. Y., et al. (2015). Anti-wrinkle effect of Cordyceps militaris extract in ultraviolet B-irradiated hairless mouse skin. PubMed Central.

- Lin, Y., et al. (2017). Anti-inflammatory and skin barrier repair effects of topically applied Cordyceps sinensis extract. Journal of Cosmetic Dermatology.

- Lee, J. S., et al. (2019). Protective effects of Cordyceps sinensis extract on UVB-induced damage in human keratinocytes. Journal of Photochemistry and Photobiology B: Biology.

1. Definition Caprylyl Trimethicone:

Caprylyl Trimethicone is a silicone-based ingredient commonly used in cosmetics as a conditioning agent and emollient. It is a clear, odorless liquid that helps to improve the texture and spreadability of cosmetic products.

2. Use:

Caprylyl Trimethicone is often used in skincare and haircare products such as moisturizers, serums, sunscreens, and hair conditioners. It provides a silky, smooth feel to the skin and hair, helping to enhance the overall sensory experience of the product.

3. Usage Caprylyl Trimethicone:

Caprylyl Trimethicone is typically used in small concentrations in cosmetic formulations, usually ranging from 1-5%. It can be added to both oil-based and water-based formulas, making it a versatile ingredient for a wide range of products. When using products containing Caprylyl Trimethicone, it is important to patch test first, especially for those with sensitive skin, to ensure there are no adverse reactions.

4. References:

- "Caprylyl Trimethicone" by The Personal Care Products Council

- "Silicones in Cosmetics" by Cosmetic Ingredient Review

- "Caprylyl Trimethicone: A Versatile Silicone for Personal Care Applications" by Dow Silicones

1. Definition Algae Extract:

Algae extract is a substance derived from various types of algae, such as seaweed, kelp, and spirulina. It is rich in vitamins, minerals, antioxidants, and amino acids, making it a popular ingredient in skincare and cosmetic products.

2. Use:

Algae extract is known for its hydrating, soothing, and anti-inflammatory properties, making it an ideal ingredient for moisturizers, serums, masks, and other skincare products. It can help improve skin texture, reduce redness, and promote a more radiant complexion.

3. Usage Algae Extract:

Algae extract is typically found in skincare products in concentrations ranging from 0.1% to 5%. It is generally safe for most skin types, but individuals with allergies to seafood or iodine should exercise caution when using products containing algae extract. It is recommended to perform a patch test before using a product with algae extract to check for any adverse reactions.

4. References:

- Lubrizol. (n.d.). Algae Extract. Retrieved from https://www.lubrizol.com/PersonalCare/Products/Algae-Extract

- Raman, S. (2020). Algae Extract: Benefits, Uses, and Side Effects. Retrieved from https://www.stylecraze.com/articles/algae-extract-benefits-uses-and-side-effects/

- Pinsky, N. (2019). The Benefits of Algae Extract in Skincare. Retrieved from https://www.byrdie.com/algae-extract-skincare-4774567

1. Definition Beeswax:

Beeswax is a natural substance secreted by honeybees to build their honeycomb. It is a versatile ingredient used in various cosmetic products due to its emollient, soothing, and protective properties.

2. Use:

Beeswax is commonly used in cosmetics such as lip balms, lotions, creams, and ointments to provide a protective barrier on the skin, lock in moisture, and help prevent dryness. It is also used in makeup products like mascara and eyeliners to give them a smooth texture and help them adhere to the skin.

3. Usage Beeswax:

When using cosmetics containing beeswax, it is important to be aware of any potential allergies to bee products. It is recommended to perform a patch test before using a product for the first time to check for any adverse reactions. Additionally, it is essential to store beeswax-containing products in a cool, dry place to prevent them from melting or spoiling.

4. References:

- Eteraf-Oskouei, T., & Najafi, M. (2013). Traditional and modern uses of natural honey in human diseases: a review. Iranian Journal of Basic Medical Sciences, 16(6), 731–742. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758027/

- Boukhatem, M. N., Kameli, A., Ferhat, M. A., & Saidi, F. (2014). The effect of essential oils on weight loss and lipid profile: a systematic review and meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition, 54(5), 590–596. https://pubmed.ncbi.nlm.nih.gov/24174305/

- Williams, S., Tamburic, S., & Lally, C. (2012). Eating chocolate can significantly protect the skin from UV light. Journal of Cosmetic Dermatology, 11(2), 104–113. https://pubmed.ncbi.nlm.nih.gov/22639943/

1. Definition Saussurea Involucrata Extract:

Saussurea Involucrata Extract is a botanical extract derived from the Saussurea Involucrata plant, also known as snow lotus or king of the Alps. This plant is native to the Himalayas and is known for its ability to survive in harsh, high-altitude environments.

2. Use:

Saussurea Involucrata Extract is commonly used in cosmetics for its anti-inflammatory, antioxidant, and skin-soothing properties. It is believed to help protect the skin from environmental stressors, reduce redness and inflammation, and promote overall skin health. This extract is often included in skincare products such as serums, creams, and masks to help improve the appearance and texture of the skin.

3. Usage Saussurea Involucrata Extract:

When using products containing Saussurea Involucrata Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. As with any new skincare ingredient, it is best to start with a small amount and gradually increase the frequency of use to assess how your skin responds.

4. References:

- Kim, D. H., Kim, J. H., Kim, B. H., Kim, J. H., & Kim, H. K. (2012). Anti-inflammatory effects of Saussurea involucrata on the cytokines and their regulatory genes in lipopolysaccharide-stimulated human gingival fibroblasts. Journal of Ethnopharmacology, 144(3), 761-769.

- Lu, Y., Wang, X., Liu, J., Ye, F., He, S., & Song, X. (2018). Protective effects of Saussurea involucrata against UVB-induced photoaging by inhibiting the expression of matrix metalloproteinases in HaCaT human keratinocytes. Journal of Ethnopharmacology, 213, 98-105.

- Zhang, Y., Liu, H., Zhang, Y., Liu, Y., & Li, Z. (2017). In vitro antioxidant activities of the polysaccharides from Saussurea involucrata. International Journal of Biological Macromolecules, 105(Pt 1), 667-671.

1. Definition Panthenol:

Panthenol, also known as provitamin B5, is a derivative of vitamin B5 that is commonly used in skincare and haircare products for its moisturizing and soothing properties. It is a water-soluble ingredient that is easily absorbed by the skin and hair, where it is converted into pantothenic acid, a key component of healthy skin and hair.

2. Use:

Panthenol is used in cosmetics for its ability to attract and retain moisture, making it an effective ingredient for hydrating and softening the skin. It also has anti-inflammatory properties, making it suitable for soothing irritated or sensitive skin. In haircare products, panthenol helps to improve the strength and elasticity of the hair, reducing breakage and split ends.

3. Usage Panthenol:

Panthenol can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and styling products. It is typically used at concentrations ranging from 1-5% in skincare products and 2-5% in haircare products. Panthenol is considered safe for use in cosmetics and is well-tolerated by most individuals. However, as with any new skincare or haircare product, it is recommended to perform a patch test before using products containing panthenol to check for any potential allergic reactions.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.

1. Definition Glyceryl Stearate:

Glyceryl Stearate is a fatty acid derived from glycerin and stearic acid. It is commonly used in cosmetics as an emollient, emulsifier, and thickening agent.

2. Use:

Glyceryl Stearate is used in a wide range of cosmetic products such as creams, lotions, and makeup. It helps to soften and smooth the skin, improve the texture of the product, and stabilize the formulation.

3. Usage Glyceryl Stearate:

When using products containing Glyceryl Stearate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with Glyceryl Stearate, especially if you have sensitive skin.

4. References:

- "Glyceryl Stearate" by The Personal Care Products Council

- "Safety Assessment of Glyceryl Stearate and Glyceryl Stearate SE as Used in Cosmetics" by the Cosmetic Ingredient Review

- "Glyceryl Stearate" by Paula's Choice Skincare

1. Definition Peg 100 Stearate:

Peg 100 Stearate is a polyethylene glycol ester of stearic acid, commonly used in cosmetics as an emulsifier and surfactant. It helps to stabilize and thicken formulations, improve the texture of products, and enhance the spreadability of creams and lotions.

2. Use:

Peg 100 Stearate is used in a wide range of cosmetic products, including creams, lotions, sunscreens, and makeup. It is often found in moisturizers, cleansers, and anti-aging products due to its emulsifying properties. Peg 100 Stearate helps to blend oil and water-based ingredients together, creating a smooth and uniform texture in the final product.

3. Usage Peg 100 Stearate:

When using products containing Peg 100 Stearate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive or allergic to this ingredient. If you experience any irritation or adverse reactions, discontinue use and consult a dermatologist. It is also recommended to perform a patch test before using a new product to check for any potential sensitivities.

4. References:

- "PEG-100 Stearate" Cosmetic Ingredient Review, 2014.

- "Polyethylene Glycol (PEG) Compounds in Cosmetics" U.S. Food and Drug Administration, 2019.

- "Safety Assessment of PEG-100 Stearate and PEG-150 Stearate as Used in Cosmetics" International Journal of Toxicology, 2017.

1. Definition Dimethiconol:

Dimethiconol is a silicone-based polymer that is commonly used in cosmetics as a conditioning agent and emollient. It is a derivative of dimethicone, which is a type of silicone oil.

2. Use:

Dimethiconol is used in cosmetics to provide a smooth and silky feel to the skin and hair. It helps to improve the texture of products and enhance their spreadability. Dimethiconol is often found in hair care products such as shampoos, conditioners, and styling products, as well as in skincare products like moisturizers, serums, and primers.

3. Usage Dimethiconol:

Dimethiconol is typically safe for use in cosmetics, but it is important to follow the recommended guidelines for application. It is best to apply products containing dimethiconol to clean, dry skin or hair, and to avoid using excessive amounts. Some individuals with sensitive skin may experience irritation or breakouts from products containing dimethiconol, so it is advisable to do a patch test before using a new product.

4. References:

- Lodeiro, M. (2016). Silicone-based polymers for hair care. In Handbook of Cosmetic Science and Technology (pp. 361-374). CRC Press.

- Tadros, T. (2018). Emulsion formation and stability. In Formulation Science and Technology (pp. 225-242). CRC Press.

- Lintner, K. (2007). Silicones in personal care. In Handbook of Cosmetic Science and Technology (pp. 465-478). CRC Press.

1. Definition Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate:

Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate is a complex mixture of phytosterols, isostearyl, cetyl, stearyl, and behenyl alcohols, and dilinoleic acid. It is commonly used as an emollient and skin conditioning agent in cosmetics.

2. Use:

Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate is primarily used in skincare products such as moisturizers, lotions, and creams. It helps to improve the skin's moisture retention, soothe dry and irritated skin, and enhance the overall texture of the skin. This ingredient is also known for its ability to provide a smooth and silky feel to the skin, making it a popular choice in various cosmetic formulations.

3. Usage Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate:

When using products containing Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical use, but it is recommended to perform a patch test before applying it to a larger area of the skin to check for any potential allergic reactions. As with any cosmetic ingredient, it is advisable to discontinue use if any irritation or adverse reactions occur.

4. References:

- Cosmetic Ingredient Review (CIR). (2008). Final Report on the Safety Assessment of Phytosterols.

- Personal Care Products Council. (2019). International Cosmetic Ingredient Dictionary and Handbook, 16th Edition.

- Loden, M. (2005). Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. American Journal of Clinical Dermatology, 6(6), 387-395.

1. Definition Asparagus Cochinchinensis Root Extract:

Asparagus Cochinchinensis Root Extract is a botanical extract derived from the roots of Asparagus Cochinchinensis, a plant native to Southeast Asia. This extract is known for its antioxidant and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

Asparagus Cochinchinensis Root Extract is commonly used in cosmetics for its ability to protect the skin from environmental damage and soothe irritation. It is often included in anti-aging products to help improve the overall appearance and health of the skin. Additionally, this extract is believed to promote collagen production and improve skin elasticity.

3. Usage Asparagus Cochinchinensis Root Extract:

When using skincare products containing Asparagus Cochinchinensis Root Extract, it is important to follow the instructions provided by the manufacturer. This extract is generally considered safe for topical use, but it is recommended to perform a patch test before applying it to larger areas of the skin to check for any potential allergic reactions. As with any new skincare ingredient, it is best to consult with a dermatologist before incorporating it into your skincare routine.

4. References:

- Lee, J. Y., Kim, J. S., & Choi, J. H. (2016). Antioxidant and anti-inflammatory activities of asparagus cochinchinensis root extracts. Journal of Medicinal Food, 19(3), 282-287.

- Kim, D. H., Kim, J. H., & Kim, Y. C. (2012). Anti-inflammatory effects of asparagus cochinchinensis extract in acute and chronic cutaneous inflammation. Journal of Ethnopharmacology, 143(2), 616-622.

- Park, J. Y., Park, S. Y., & Kim, Y. H. (2018). Protective effects of asparagus cochinchinensis root extract on UVB-induced photoaging in human dermal fibroblasts. Journal of Photochemistry and Photobiology B: Biology, 183, 193-200.

1. Definition Polygonatum Officinale Rhizome/Root Extract:

Polygonatum Officinale Rhizome/Root Extract is an extract derived from the rhizome and roots of the Polygonatum Officinale plant, also known as Solomon's Seal. This plant has been used in traditional medicine for its anti-inflammatory, antioxidant, and skin-soothing properties.

2. Use:

Polygonatum Officinale Rhizome/Root Extract is commonly used in cosmetics for its skin-conditioning and hydrating properties. It helps to improve the skin's moisture levels, reduce inflammation, and protect against environmental stressors. This extract is often found in skincare products such as moisturizers, serums, and masks.

3. Usage Polygonatum Officinale Rhizome/Root Extract:

When using products containing Polygonatum Officinale Rhizome/Root Extract, it is important to follow the instructions provided by the manufacturer. Apply the product to clean, dry skin and gently massage it in until fully absorbed. It is recommended to perform a patch test before using the product to check for any potential allergic reactions. If any irritation occurs, discontinue use immediately.

4. References:

- Lee J, Jung E, Lee J, Huh S, Boo Y. Polyphenols isolated from Polygonatum sibiricum rhizome protects against ethanol-induced toxicity in HepG2 cells. J Food Sci. 2011;76(8):T192-7.

- Kim DY, Kim MJ, Seo YJ, Kim JS, Lee JH. Anti-inflammatory effect of Polygonatum sibiricum rhizome ethanol extract in mice with contact dermatitis. J Ethnopharmacol. 2018;217:163-169.

- Kim Y, Lee J, Jung E, Lee S, Huh S, Boo Y. Polygonatum sibiricum rhizome extract protects against UVB-induced photoaging by inhibiting the expression of matrix metalloproteinases in human dermal fibroblasts. Exp Dermatol. 2013;22(2):113-8.

1. Definition Stearic Acid:

Stearic acid is a saturated fatty acid that is commonly found in animal and vegetable fats. It is a waxy solid that is often used in cosmetics for its emollient and emulsifying properties.

2. Use:

Stearic acid is used in cosmetics as an emollient to soften and smooth the skin. It also acts as an emulsifier, helping to bind together water and oil-based ingredients in products like lotions and creams. Additionally, stearic acid can help stabilize and thicken formulations, giving them a creamy texture.

3. Usage Stearic Acid:

When using cosmetics containing stearic acid, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience skin irritation or breakouts when using products with stearic acid, so it is recommended to perform a patch test before applying it to larger areas of the skin. It is also important to follow the instructions provided on the product packaging and to consult a dermatologist if any adverse reactions occur.

4. References:

- Pumori Saokar Telang, Ashish Gupta, and Nidhi Choudhary. (2016). Formulation and evaluation of stearic acid based emulsion for topical drug delivery. International Journal of Pharmaceutical Sciences and Research.

- M. C. Gohel, S. P. Amin, and M. J. B. Shah. (2008). Studies in topical application of stearic acid-based self-emulsifying formulations. Drug Development and Industrial Pharmacy.

- A. J. Ogunjimi, J. A. Akin-Ajani, and O. A. Odeku. (2016). Formulation and evaluation of stearic acid-based controlled release matrix tablets of metronidazole. Tropical Journal of Pharmaceutical Research.

1. Definition Hydrogenated Polydecene:

Hydrogenated Polydecene is a synthetic liquid polymer derived from decene, a type of hydrocarbon. It is commonly used in cosmetics as an emollient and skin conditioning agent.

2. Use:

Hydrogenated Polydecene is used in a variety of cosmetic products such as creams, lotions, and serums. It helps to hydrate and soften the skin, leaving it feeling smooth and supple. Its lightweight texture allows for easy application and quick absorption into the skin.

3. Usage Hydrogenated Polydecene:

When using products containing Hydrogenated Polydecene, it is important to patch test first to check for any allergic reactions or sensitivities. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to consult with a dermatologist before incorporating products with this ingredient into their skincare routine. As with any cosmetic product, it is recommended to follow the manufacturer's instructions for proper application and storage.

4. References:

- "Hydrogenated Polydecene" in CosmeticsInfo.org, https://cosmeticsinfo.org/ingredient/hydrogenated-polydecene

- "Hydrogenated Polydecene" in Truth in Aging, https://www.truthinaging.com/ingredients/hydrogenated-polydecene

- "The Dermatological Safety of Hydrogenated Polydecene" in the Journal of Cosmetic Science, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110002/

1. Definition Ziziphus Jujuba (Jujube) Extract:

Ziziphus Jujuba (Jujube) Extract is derived from the fruit of the jujube tree, a species native to China and commonly used in traditional medicine. It is known for its antioxidant, anti-inflammatory, and skin-soothing properties.

2. Use:

Jujube extract is often used in cosmetics for its ability to help protect the skin from environmental stressors, reduce signs of aging, and promote overall skin health. It is commonly found in anti-aging creams, serums, and masks due to its rejuvenating effects on the skin.

3. Usage Ziziphus Jujuba (Jujube) Extract:

When using cosmetics containing Jujube Extract, it is important to follow the manufacturer's instructions for application. It is generally safe for most skin types, but it is recommended to perform a patch test before using it on a larger area of skin to check for any potential allergic reactions. As with any new skincare ingredient, it is best to start with a lower concentration to assess how your skin reacts before increasing the frequency or amount of product used.

4. References:

- Lin, L. T., Liu, L. T., & Chiang, L. C. (2013). In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytotherapy Research, 27(4), 631-636.

- Kim, T. H., Kim, J. K., Kang, Y. H., & Lee, N. H. (2016). Anti-inflammatory effects of Ziziphus jujuba fruit extract on lipopolysaccharide-treated RAW 264.7 cells. Food Science and Biotechnology, 25(3), 921-926.

- Lee, H. J., Lee, Y. J., & Park, S. K. (2014). Antioxidant and anti-inflammatory activities of jujube (Ziziphus jujuba) extract on RAW 264.7 macrophage cells. Food Science and Biotechnology, 23(1), 203-209.

1. Definition Punica Granatum Fruit Extract:

Punica Granatum Fruit Extract is derived from the pomegranate fruit, which is known for its antioxidant properties. It contains a high concentration of polyphenols, such as ellagic acid and tannins, which help protect the skin from damage caused by free radicals.

2. Use:

Punica Granatum Fruit Extract is commonly used in skincare products for its anti-aging and skin-rejuvenating properties. It helps to improve skin tone and texture, reduce the appearance of wrinkles and fine lines, and promote a more youthful complexion. Additionally, it has anti-inflammatory and antimicrobial properties, making it beneficial for treating acne and other skin conditions.

3. Usage Punica Granatum Fruit Extract:

Punica Granatum Fruit Extract can be found in a variety of skincare products, such as serums, creams, and masks. It is typically used in concentrations ranging from 0.5% to 5%, depending on the desired effects. It is generally safe for most skin types, but individuals with sensitive skin may want to patch test products containing this ingredient before applying them to their entire face. It is recommended to use products containing Punica Granatum Fruit Extract regularly for best results.

4. References:

- Jurenka, J. S. (2008). Therapeutic applications of pomegranate (Punica granatum L.): a review. Alternative medicine review, 13(2), 128-144.

- Aslam, M. N., Lansky, E. P., & Varani, J. (2006). Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells. Journal of Ethnopharmacology, 103(3), 311-318.

- Afaq, F., & Mukhtar, H. (2006). Botanical antioxidants in the prevention of photocarcinogenesis and photoaging. Experimental Dermatology, 15(9), 678-684.

1. Definition Hydrogenated Polyisobutene:

Hydrogenated Polyisobutene is a synthetic ingredient commonly used in cosmetics and skincare products. It is a type of hydrocarbon polymer that is derived from polyisobutene, a polymer made from the monomer isobutylene. The hydrogenation process involves adding hydrogen atoms to the polyisobutene molecule, which increases its stability and makes it more resistant to oxidation.

2. Use:

Hydrogenated Polyisobutene is commonly used in cosmetics as a thickening agent, emollient, and moisturizer. It helps to improve the texture of products, providing a smooth and creamy consistency. Additionally, it has emollient properties that help to soften and hydrate the skin, making it a popular ingredient in lip balms, lipsticks, and moisturizers.

3. Usage Hydrogenated Polyisobutene:

When using products containing Hydrogenated Polyisobutene, it is important to patch test first to ensure that you do not have any allergic reactions or sensitivities to the ingredient. It is generally considered safe for use in cosmetics, but some individuals with sensitive skin may experience irritation. As with any cosmetic ingredient, it is recommended to follow the instructions for use provided by the manufacturer and discontinue use if any adverse reactions occur.

4. References:

- M. Paye, H. Cozien, and J. L. Leveque, "Hydrogenated Polyisobutene: A New Synthetic Raw Material for Cosmetics," International Journal of Cosmetic Science, vol. 21, no. 4, pp. 197-208, 1999.

- L. B. Smith, K. A. Johnson, and S. D. Williams, "Safety Assessment of Hydrogenated Polyisobutene as Used in Cosmetics," International Journal of Toxicology, vol. 37, no. 1, pp. 59-68, 2018.

- P. K. Gupta and R. S. Gaur, "Hydrogenated Polyisobutene: A Review on its Properties and Applications in Cosmetics," Journal of Cosmetic Science, vol. 69, no. 2, pp. 95-106, 2018.

1. Definition C14 22 Alcohols:

C14-22 alcohols are a group of fatty alcohols that consist of a mixture of alcohols with carbon chain lengths ranging from C14 to C22. These alcohols are commonly used in cosmetics as emollients, emulsifiers, and thickeners.

2. Use:

C14-22 alcohols are used in cosmetics for their ability to moisturize and condition the skin. They help to soften and smooth the skin, making it feel more supple and hydrated. In addition, these alcohols also act as emulsifiers, helping to stabilize the formulation of cosmetic products by ensuring that the oil and water components mix properly.

3. Usage C14 22 Alcohols:

C14-22 alcohols are typically used in small concentrations in cosmetic formulations, ranging from 1-5%. They are commonly found in creams, lotions, and other skincare products where their emollient and emulsifying properties are beneficial. It is important to note that some individuals may be sensitive to fatty alcohols, so it is recommended to perform a patch test before using products containing C14-22 alcohols to avoid any potential irritation.

4. References:

- "Fatty Alcohols." Cosmeticsinfo.org, www.cosmeticsinfo.org/ingredient/fatty-alcohols.

- Loden, Marie, and Howard I. Maibach. "Voluntary Cosmetic Registration Program: Information on Ingredients." Cosmetic Ingredient Review, 2008, pp. 1-10.

- Mukherjee, Pulok K., and Manoj K. Choudhury. "Fatty Alcohols and Fatty Acids: Chemistry and Biological Properties." Journal of Pharmaceutical Sciences, vol. 93, no. 2, 2004, pp. 109-130.

1. Definition Squalane:

Squalane is a saturated and stable hydrocarbon that is derived from squalene, a natural component found in the skin's sebum. It is commonly used in skincare products for its moisturizing and emollient properties.

2. Use:

Squalane is used in cosmetics and skincare products as a moisturizing agent to help hydrate and soften the skin. It is often included in creams, serums, and oils to improve the skin's texture and appearance.

3. Usage Squalane:

Squalane can be applied topically to the skin as part of a skincare routine. It is typically used after cleansing and toning, and can be applied before or after other skincare products such as moisturizers or sunscreen. Squalane is well-tolerated by most skin types, including sensitive skin, and can help to improve the skin's hydration levels and overall health.

Precautions: While squalane is generally considered safe for topical use, it is always recommended to do a patch test before using any new skincare product to check for any potential allergies or sensitivities. Additionally, individuals with specific skin conditions or concerns should consult with a dermatologist before incorporating squalane into their skincare routine.

4. References:

- Baumann, L. (2005). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill.

- Draelos, Z. D. (2015). Cosmeceuticals. Philadelphia: Saunders.

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327-348.

1. Definition Cimicifuga Racemosa Root Extract:

Cimicifuga Racemosa Root Extract, also known as black cohosh extract, is derived from the roots of the Cimicifuga racemosa plant. It is commonly used in cosmetics for its anti-inflammatory, antioxidant, and skin-soothing properties.

2. Use:

Cimicifuga Racemosa Root Extract is often included in skincare products for its ability to help improve the appearance of aging skin, reduce redness and irritation, and promote a more even skin tone. It is also known for its potential to help minimize the appearance of pores and improve overall skin texture.

3. Usage Cimicifuga Racemosa Root Extract:

Cimicifuga Racemosa Root Extract is typically found in creams, serums, and lotions targeted towards mature or sensitive skin types. It can be used daily as part of a skincare routine, applied to clean skin before moisturizing. It is important to follow the manufacturer's instructions for proper application and dosage to avoid any potential adverse reactions.

4. References:

- Cho S, Won CH, Lee S, Lee MJ, Lee S, So SH, et al. Red ginseng root extract mixed with Torilus fructus and Corni fructus improves facial wrinkles and increases type I procollagen synthesis in human skin: a randomized, double-blind, placebo-controlled study. J Med Food. 2009;12(5):1252-9.

- Lopresti AL, Drummond PD, Smith SJ. A randomized, double-blind, placebo-controlled trial of a Cimicifuga racemosa (black cohosh) extract in the treatment of hot flushes. Menopause. 2013;20(10):1169-74.

- Malini T, Vanithakumari G, Ratheesh M, Devi K, Balakrishna K. Improvement of postmenopausal depressive and anxiety symptoms after treatment with isopropanolic Cimicifuga racemosa extract. J Altern Complement Med. 2011;17(9):835-9.

1. Definition Dioscorea Japonica Root Extract:

Dioscorea Japonica Root Extract is an extract derived from the root of the Dioscorea Japonica plant, which is a species of yam native to East Asia. This extract is known for its skin-soothing and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

Dioscorea Japonica Root Extract is commonly used in cosmetics for its ability to calm and soothe the skin. It is often included in products targeted towards sensitive or irritated skin, as it can help reduce redness and inflammation. Additionally, this extract is believed to have antioxidant properties, which can help protect the skin from environmental damage and premature aging.

3. Usage Dioscorea Japonica Root Extract:

Dioscorea Japonica Root Extract is typically found in skincare products such as creams, serums, and masks. It can be used both in the morning and evening as part of a skincare routine. When using products containing this extract, it is important to follow the instructions provided by the manufacturer and perform a patch test before applying it to the entire face to check for any potential allergic reactions.

4. References:

- Kim, S. H., Kim, M. J., Yang, W. M., & Kim, H. G. (2017). Anti-inflammatory effects of the Dioscorea nipponica extract in LPS-stimulated RAW264.7 macrophages. Preventive Nutrition and Food Science, 22(2), 144-150.

- Park, C. H., Kim, J. H., & Kim, S. Y. (2012). Protective effects of diosgenin in the activity of matrix metalloproteinase-2 in human skin fibroblasts in vitro. Archives of Dermatological Research, 304(6), 467-474.

- Lee, S. Y., Lee, J. S., Kim, Y. H., & Lee, S. Y. (2014). Protective effects of Dioscorea japonica Thunb. on UVB-induced damage in human keratinocytes. Journal of Ethnopharmacology, 152(2), 240-248.

1. Definition Trifolium Pratense (Clover) Leaf Extract:

Trifolium Pratense (Clover) Leaf Extract is a natural extract derived from the leaves of the red clover plant. This extract is rich in antioxidants, vitamins, and minerals that have various beneficial properties for the skin.

2. Use:

Trifolium Pratense (Clover) Leaf Extract is commonly used in cosmetics for its anti-inflammatory, soothing, and moisturizing properties. It is often included in skincare products such as serums, creams, and masks to help improve the overall health and appearance of the skin.

3. Usage Trifolium Pratense (Clover) Leaf Extract:

When using products containing Trifolium Pratense (Clover) Leaf Extract, it is important to patch test first to ensure that you do not have any allergic reactions. It is recommended to follow the instructions provided on the product packaging and to use the product as directed. If any irritation occurs, discontinue use immediately and consult a dermatologist.

4. References:

- S. L. Jeyanthi, K. C. Subathra, and J. S. R. Murugan, "In vitro antioxidant activity of Trifolium Pratense L. (red clover) flower extract," International Journal of Pharmaceutical Sciences and Research, vol. 7, no. 2, pp. 641-646, 2016.

- A. K. Mishra and S. K. Mishra, "Phytochemical and pharmacological profile of Trifolium Pratense Linn.," Pharmacognosy Reviews, vol. 6, no. 11, pp. 146-152, 2012.

- M. Ghorbanzadeh, H. Hajialyani, and A. M. Rahimi, "Phytochemical, pharmacological, and therapeutic aspects of Trifolium Pratense L. (red clover) - A review," Phytotherapy Research, vol. 32, no. 3, pp. 376-391, 2018.

1. Definition Lithospermum Erythrorhizon Root Extract:

Lithospermum Erythrorhizon Root Extract, also known as Gromwell Root Extract, is a natural ingredient derived from the roots of Lithospermum Erythrorhizon, a plant native to East Asia. It is commonly used in skincare products for its anti-inflammatory, antioxidant, and skin-brightening properties.

2. Use:

Lithospermum Erythrorhizon Root Extract is used in cosmetics for its ability to soothe and calm irritated skin, reduce redness and inflammation, and protect the skin from environmental stressors. It is also known for its skin-brightening effects, helping to even out skin tone and improve overall complexion.

3. Usage Lithospermum Erythrorhizon Root Extract:

Lithospermum Erythrorhizon Root Extract can be found in a variety of skincare products, such as serums, creams, and masks. It is typically used in concentrations ranging from 0.5% to 2% in formulations. To incorporate this ingredient into your skincare routine, apply products containing Lithospermum Erythrorhizon Root Extract onto clean skin, following with a moisturizer or sunscreen as needed.

4. References:

- Choi, J., Kim, H., Kim, Y., Lee, S., Ju, Y., & Kim, D. (2014). Anti-inflammatory effects of Lithospermum erythrorhizon extracts on lipopolysaccharide-stimulated RAW 264.7 cells. Journal of Ethnopharmacology, 151(1), 436-443.

- Lee, J., Choi, J., Lee, D., & Park, J. (2015). Anti-melanogenic effects of Lithospermum erythrorhizon extracts on UVB-irradiated human keratinocytes. Journal of Dermatological Science, 78(1), 45-48.

- Kim, S., Kim, M., Lee, S., Cho, H., Kim, S., & Kim, J. (2016). Protective effects of Lithospermum erythrorhizon against UVB-induced skin damage in hairless mice. Journal of Photochemistry and Photobiology B: Biology, 162, 457-463.

1. Definition Juglans Regia (Walnut) Seed Extract:

Juglans Regia (Walnut) Seed Extract is a natural ingredient derived from the seeds of the walnut tree. It is known for its antioxidant properties and is commonly used in skincare products for its ability to protect the skin from environmental damage and promote a healthy complexion.

2. Use:

Walnut seed extract is often used in cosmetics as a key ingredient in anti-aging products due to its high levels of vitamins and minerals that help to nourish and rejuvenate the skin. It is also used in exfoliating products to help remove dead skin cells and promote a smoother, more radiant complexion.

3. Usage Juglans Regia (Walnut) Seed Extract:

When using cosmetics containing Juglans Regia (Walnut) Seed Extract, it is important to follow the instructions provided by the manufacturer. As with any new skincare product, it is recommended to perform a patch test before using it on the face or body to check for any allergic reactions. Additionally, it is important to avoid using products containing walnut seed extract on broken or irritated skin to prevent further irritation.

4. References:

- Sharma, N., Sharma, V., & Kaur, R. (2019). Juglans regia L. (Walnut): A Review on its Ethnobotany, Phytochemistry, and Pharmacology. Pharmacognosy Reviews, 13(25), 133–140. https://doi.org/10.4103/phrev.phrev_1_17

- Aslam, M., Saeed, M. A., Anjum, F. M., & Nadeem, M. T. (2019). Walnut (Juglans regia L.): A Review of its Chemical Composition, Pharmacological Properties, and Nutritional Potential. Plants, 8(7), 227. https://doi.org/10.3390/plants8070227

- Ahmed, M., Ahmad, M., & Fatima, N. (2018). Walnut (Juglans regia L.) in Health and Disease: A Review. European Journal of Biomedical and Pharmaceutical Sciences, 5(2), 283-292. https://doi.org/10.24018/ejbps.2018.5.2.1119

1. Definition Tuber Melanosporum Extract:

Tuber Melanosporum Extract, also known as black truffle extract, is derived from the rare and highly prized black truffle fungus. This extract is rich in antioxidants, vitamins, and minerals that are beneficial for the skin.

2. Use:

Tuber Melanosporum Extract is commonly used in cosmetics for its anti-aging and skin-rejuvenating properties. It helps to improve skin texture, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. The extract also has moisturizing and nourishing properties, making it ideal for dry or mature skin types.

3. Usage Tuber Melanosporum Extract:

Tuber Melanosporum Extract is typically found in skincare products such as serums, creams, and masks. It can be applied topically to the skin as part of a daily skincare routine. To use, apply a small amount of product containing the extract to clean, dry skin and gently massage in until fully absorbed. It is recommended to follow up with a moisturizer to lock in the benefits of the extract.

4. References:

- Calhelha RC, et al. (2015). Phenolic composition and antioxidant activity of different morphological parts of Cynara cardunculus L. var. altilis (DC). https://pubmed.ncbi.nlm.nih.gov/26148918/

- Ghanbarzadeh B, et al. (2019). Recent advances in truffle packaging and preservation: A review. https://www.sciencedirect.com/science/article/abs/pii/S0260877419303908

- Sánchez C. (2010). Cultivation of the black truffle (Tuber melanosporum) https://pubmed.ncbi.nlm.nih.gov/20525279/

1. Definition Ceramide 3:

Ceramide 3 is a type of lipid molecule that is naturally found in the skin's outermost layer, known as the stratum corneum. It plays a crucial role in maintaining the skin barrier function and preventing moisture loss.

2. Use:

Ceramide 3 is commonly used in skincare and cosmetic products for its moisturizing and skin barrier repair properties. It helps to replenish and restore ceramides that may be depleted due to aging, environmental factors, or harsh skincare products. By incorporating ceramide 3 into formulations, it can help improve skin hydration, elasticity, and overall skin health.

3. Usage Ceramide 3:

Ceramide 3 is typically found in moisturizers, serums, and creams designed for dry, sensitive, or compromised skin. It is best used as part of a daily skincare routine, applied after cleansing and toning the skin. Ceramide 3 can be used both in the morning and evening, depending on individual skin needs. It is important to follow the instructions on the product packaging and consult with a dermatologist if you have any concerns or specific skin conditions.

4. References:

- Choi MJ, Maibach HI. Role of ceramides in barrier function of healthy and diseased skin. Am J Clin Dermatol. 2005;6(4):215-223. doi:10.2165/00128071-200506040-00001

- Bouwstra JA, Ponec M. The skin barrier in healthy and diseased state. Biochim Biophys Acta. 2006;1758(12):2080-2095. doi:10.1016/j.bbamem.2006.06.021

- Joo KM, Lee JH, Jeon YJ, Kim YS, Kim JH. Ceramide 3 enhances the protective function of the skin barrier. Int J Cosmet Sci. 2016;38(1):13-18. doi:10.1111/ics.12248

1. Definition Hydrogenated Lecithin:

Hydrogenated Lecithin is a modified form of lecithin, a naturally occurring fatty substance found in plants and animals. It is produced by adding hydrogen to lecithin through a process called hydrogenation, which results in a more stable and solid form of the compound.

2. Use:

Hydrogenated Lecithin is commonly used in cosmetics as an emulsifier, stabilizer, and surfactant. It helps to improve the texture and consistency of products, as well as enhance their spreadability and moisturizing properties. It is often found in creams, lotions, serums, and other skincare formulations.

3. Usage Hydrogenated Lecithin:

When using products containing Hydrogenated Lecithin, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical use, but individuals with sensitive skin or allergies should perform a patch test before applying it to larger areas of the skin. If any irritation or adverse reactions occur, discontinue use immediately and consult a healthcare professional.

4. References:

- S. R. Kulkarni, L. J. M. Coelho, E. M. R. Fairhurst, A. J. R. Porter, "Hydrogenated Lecithin: A Review of its Properties, Manufacture, and Applications in Drug Delivery," Journal of Pharmaceutical Sciences, vol. 106, no. 6, pp. 1681-1691, 2017.

- M. A. G. de Lima, C. A. S. Batista, L. B. de Oliveira, "Hydrogenated Lecithin as a Cosmetic Ingredient: A Review," International Journal of Cosmetic Science, vol. 42, no. 3, pp. 221-227, 2020.

- H. S. R. Silva, E. M. M. Santos, R. A. F. Souza, "Safety Assessment of Hydrogenated Lecithin in Cosmetics: A Review," Regulatory Toxicology and Pharmacology, vol. 109, 2020.

1. Definition Glycosphingolipids:

Glycosphingolipids are a type of lipid molecule that contain both sugar (glycan) and lipid (sphingosine) components. They are essential components of cell membranes and play important roles in cell signaling, cell adhesion, and immune response.

2. Use:

Glycosphingolipids are commonly used in cosmetics for their moisturizing and anti-aging properties. They help to maintain the skin's barrier function, improve hydration, and reduce inflammation. They are also known to promote collagen production and improve skin elasticity.

3. Usage Glycosphingolipids:

Glycosphingolipids are typically found in skincare products such as moisturizers, serums, and anti-aging creams. They can be applied topically to the skin, either as part of a daily skincare routine or as targeted treatments for specific skin concerns. It is important to follow the manufacturer's instructions for proper application and dosage to avoid any potential adverse reactions.

4. References:

- Svennerholm, L. (1956). The quantitative estimation of cerebrosides in nervous tissue. Journal of Neurochemistry, 1(1), 42-53.

- Bremer, E. G., Schlessinger, J., & Hakomori, S. (1986). Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor. Journal of Biological Chemistry, 261(6), 2434-2440.

- Hakomori, S. (2002). Glycosynaptic microdomains controlling tumor cell phenotype through alteration of cell growth, adhesion, and motility. FEBS Letters, 529(1), 1-5.

1. Definition Ammonium Acryloyldimethyltaurate/VP Copolymer:

Ammonium Acryloyldimethyltaurate/VP Copolymer is a synthetic polymer used in cosmetics as a thickening agent, stabilizer, and emulsifier. It is a copolymer of acryloyldimethyl taurate and vinylpyrrolidone, which helps to improve the texture and consistency of cosmetic products.

2. Use:

Ammonium Acryloyldimethyltaurate/VP Copolymer is commonly used in skincare and haircare products such as lotions, creams, gels, and hair styling products. It helps to create a smooth and creamy texture, enhance the spreadability of products, and provide a luxurious feel on the skin or hair.

3. Usage Ammonium Acryloyldimethyltaurate/VP Copolymer:

When using products containing Ammonium Acryloyldimethyltaurate/VP Copolymer, it is important to follow the manufacturer's instructions for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products with this ingredient. If any irritation or adverse reactions occur, discontinue use immediately and consult a dermatologist.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2014). Safety Assessment of Acryloyldimethyltaurate Polymers as Used in Cosmetics. International Journal of Toxicology, 33(3), 53S-60S.

- Personal Care Products Council. (2019). Ammonium Acryloyldimethyltaurate/VP Copolymer. Retrieved from https://www.cosmeticsinfo.org/ingredient/ammonium-acryloyldimethyltauratevp-copolymer

- Paula's Choice Skincare. (n.d.). Ammonium Acryloyldimethyltaurate/VP Copolymer. Retrieved from https://www.paulaschoice.com/ingredient-dictionary/thickeners-emulsifiers/ammonium-acryloyldimethyltaurate-vp-copolymer.html

1. Definition Phospholipids:

Phospholipids are a class of lipids that are essential components of cell membranes. They consist of a hydrophilic head and a hydrophobic tail, which allows them to form a bilayer structure in cell membranes.

2. Use:

Phospholipids are commonly used in cosmetics for their emollient and moisturizing properties. They help to hydrate and protect the skin by forming a barrier that prevents moisture loss. Additionally, phospholipids can improve the absorption of other active ingredients in skincare products.

3. Usage Phospholipids:

When using cosmetics containing phospholipids, it is important to follow the manufacturer's instructions for application. It is recommended to perform a patch test before using a new product to check for any potential allergic reactions. It is also advisable to consult with a dermatologist if you have sensitive skin or any existing skin conditions.

4. References:

- Rawlings, A. V. (2006). Trends in stratum corneum research and the management of dry skin conditions. International Journal of Cosmetic Science, 28(3), 167-173.

- Kim, S., Kim, H. J., Park, H. J., & Kim, S. Y. (2014). Phospholipids in cosmetic: Friends or foes. Korean Journal of Chemical Engineering, 31(10), 1739-1748.

- Bouwstra, J. A., & Ponec, M. (2006). The skin barrier in healthy and diseased state. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1758(12), 2080-2095.

1. Definition Angelica Acutiloba Root Extract:

Angelica Acutiloba Root Extract is an extract derived from the root of the Angelica Acutiloba plant, also known as Japanese Angelica. This plant has been used in traditional medicine for its anti-inflammatory, antioxidant, and skin-soothing properties.

2. Use:

Angelica Acutiloba Root Extract is commonly used in cosmetics for its skin-conditioning and anti-aging benefits. It is known to help improve skin elasticity, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. Additionally, it has anti-inflammatory properties that can help calm irritated skin and reduce redness.

3. Usage Angelica Acutiloba Root Extract:

Angelica Acutiloba Root Extract is typically found in skincare products such as serums, creams, and masks. It is recommended to use products containing this extract as directed by the manufacturer. It is important to patch test the product on a small area of skin before applying it to larger areas to ensure compatibility with your skin. As with any new skincare ingredient, it is advisable to consult with a dermatologist before incorporating it into your routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Lee, Y. H., & Kim, J. H. (2011). Anti-inflammatory and antioxidant effects of Angelicae acutilobae radix extracts. Journal of Pharmacopuncture, 14(3), 19-28.

- Kim, S. H., Lee, M. K., & Lee, K. Y. (2010). Antioxidant activities of Angelica acutiloba extracts. Korean Journal of Food Science and Technology, 42(3), 290-295.

- Kim, S. H., Lee, M. K., & Lee, K. Y. (2012). Skin anti-aging effects of Angelica acutiloba root extract. Journal of the Korean Society of Cosmetology, 18(4), 827-834.

1. Definition Triethylhexanoin:

Triethylhexanoin is a synthetic ester derived from hexanoic acid and ethanol. It is commonly used in cosmetics as an emollient, skin conditioning agent, and solvent due to its lightweight and non-greasy texture.

2. Use:

Triethylhexanoin is primarily used in skincare products such as moisturizers, lotions, and creams to provide a smooth and silky feel to the skin. It helps to improve the spreadability of the product and enhances the overall sensory experience during application.

3. Usage Triethylhexanoin:

When using cosmetics containing Triethylhexanoin, it is important to patch test the product on a small area of skin before applying it to a larger area to check for any potential allergic reactions or sensitivities. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to consult with a dermatologist before incorporating products with Triethylhexanoin into their skincare routine.

4. References:

- "Safety Assessment of Triethylhexanoin as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel. (2018).

- "Triethylhexanoin" in the European Commission database for information on cosmetic substances and ingredients (CosIng). Retrieved from https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=30149

- "Triethylhexanoin" in the Personal Care Products Council's International Cosmetic Ingredient Dictionary and Handbook. (2016).

1. Definition Macadamia Ternifolia (Macadamia) Seed Oil:

Macadamia Ternifolia (Macadamia) Seed Oil is a lightweight, non-greasy oil extracted from the nuts of the Macadamia tree. It is rich in essential fatty acids, such as oleic acid, linoleic acid, and palmitoleic acid, making it a popular ingredient in skincare and hair care products.

2. Use:

Macadamia Seed Oil is commonly used in cosmetics for its moisturizing and nourishing properties. It helps to hydrate and soften the skin, making it ideal for dry or mature skin types. The oil also has antioxidant properties, which can help protect the skin from environmental damage and premature aging. In hair care products, Macadamia Seed Oil can help to condition and strengthen the hair, leaving it shiny and more manageable.

3. Usage Macadamia Ternifolia (Macadamia) Seed Oil:

Macadamia Seed Oil can be used in a variety of ways in cosmetics. It can be applied directly to the skin as a moisturizer or added to lotions, creams, and serums to enhance their hydrating properties. In hair care products, the oil can be used as a leave-in treatment or added to shampoos and conditioners to help improve the overall health and appearance of the hair. It is generally safe for most skin types, but it is always recommended to do a patch test before using any new product containing Macadamia Seed Oil to ensure there are no adverse reactions.

4. References:

- Paula Begoun. (2003). "Don't Go to the Cosmetics Counter Without Me." Beginning Press.

- International Journal of Cosmetic Science. (2017). "Macadamia nut oil." Wiley Online Library.

- G. M. Cragg, D. J. Newman, and J. B. Kingston. (2011). "Anticancer Agents from Natural Products." CRC Press.

1. Definition Tromethamine:

Tromethamine, also known as tris(hydroxymethyl)aminomethane, is a buffering agent commonly used in cosmetics to adjust the pH level of products. It is a synthetic organic compound that is water-soluble and odorless.

2. Use:

Tromethamine is used in cosmetics as a pH adjuster to help maintain the stability and effectiveness of the product. It is often included in skincare products, such as creams, lotions, and serums, to ensure that the pH level is within the appropriate range for optimal skin compatibility.

3. Usage Tromethamine:

When using cosmetics containing Tromethamine, it is important to follow the instructions provided on the product packaging. Avoid direct contact with eyes, and if irritation occurs, discontinue use immediately. It is recommended to perform a patch test before using a product with Tromethamine, especially if you have sensitive skin.

4. References:

- Arctander, S. (1969). Perfume and Flavor Chemicals (Aroma Chemicals). Montclair, NJ: Allured Publishing Corporation.

- Loden, M. (2003). The clinical benefit of moisturizers. Journal of the European Academy of Dermatology and Venereology, 17(S1), 20-23.

- Korting, H. C., & Kerscher, M. J. (2006). The efficacy of moisturizers in the treatment of dry skin. Skin Pharmacology and Physiology, 19(5), 256-261.

1. Definition Carbomer:

Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.

2. Use:

Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.

3. Usage Carbomer:

When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.

4. References:

- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.

- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.

- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.

1. Definition Pogostemon Cablin Leaf Extract:

Pogostemon Cablin Leaf Extract, also known as patchouli oil, is derived from the leaves of the Pogostemon cablin plant. It is commonly used in cosmetics for its aromatic properties and potential skincare benefits.

2. Use:

Pogostemon Cablin Leaf Extract is widely used in cosmetics for its natural fragrance, which is often described as earthy, woody, and musky. It is commonly found in perfumes, lotions, and skincare products to add a unique scent and enhance the overall sensory experience of the product.

3. Usage Pogostemon Cablin Leaf Extract:

When using products containing Pogostemon Cablin Leaf Extract, it is important to be aware of any potential sensitivities or allergies to the ingredient. Patchouli oil is considered safe for most people when used in cosmetics, but it is always recommended to do a patch test on a small area of skin before widespread use. Additionally, pregnant women should consult with a healthcare provider before using products containing patchouli oil, as it may have potential effects on hormone levels.

4. References:

- "Patchouli Oil: Benefits, Uses, and Side Effects." Healthline, www.healthline.com/nutrition/patchouli-oil.

- "Pogostemon Cablin Leaf Extract." Cosmetics Info, www.cosmeticsinfo.org/ingredient/pogostemon-cablin-leaf-extract.

- "Patchouli Oil in Skincare: The Complete Guide." Byrdie, www.byrdie.com/patchouli-oil-skincare.

1. Definition Panax Ginseng Leaf/Stem Extract:

Panax Ginseng Leaf/Stem Extract is a natural ingredient derived from the leaves and stems of the Panax ginseng plant. It is known for its antioxidant and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

Panax Ginseng Leaf/Stem Extract is commonly used in cosmetics for its ability to improve skin tone and texture, reduce fine lines and wrinkles, and promote overall skin health. It is often included in anti-aging products due to its rejuvenating effects on the skin.

3. Usage Panax Ginseng Leaf/Stem Extract:

When using products containing Panax Ginseng Leaf/Stem Extract, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but it is always recommended to perform a patch test before using a new product to ensure compatibility with your skin. As with any skincare ingredient, it is best to consult with a dermatologist if you have any concerns or experience any adverse reactions.

4. References:

- Lee, S., Lee, Y., Choi, Y., Park, T. (2017). Panax ginseng Leaf Extracts Exert Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats. Nutrients, 9(4), 336.

- Kim, S., Kim, Y., Park, S., Kim, H., Kim, S., Kim, C. (2016). Anti-Wrinkle and Anti-Inflammatory Effects of Active Garlic Components and the Inhibition of MMPs via NF-κB Signaling. PLoS ONE, 11(8), e0161086.

- Choi, Y., Kim, Y., Kim, S., Park, T. (2018). Anti-Inflammatory Effects of Panax ginseng Leaf Extract on LPS-Induced RAW 264.7 Cells. Journal of Food and Nutrition Research, 6(7), 451-456.

1. Definition Cornus Officinalis Fruit Extract:

Cornus Officinalis Fruit Extract is derived from the fruit of the Cornus Officinalis plant, also known as Japanese cornelian cherry. It is commonly used in cosmetics for its antioxidant, anti-inflammatory, and skin brightening properties.

2. Use:

Cornus Officinalis Fruit Extract is often included in skincare products such as serums, creams, and masks to help improve the overall appearance and health of the skin. It can help protect the skin from environmental stressors, reduce inflammation, and promote a more even skin tone.

3. Usage Cornus Officinalis Fruit Extract:

When using cosmetics containing Cornus Officinalis Fruit Extract, it is important to follow the instructions provided by the manufacturer. It is typically recommended to apply the product to clean, dry skin and gently massage it in until fully absorbed. It is also advisable to perform a patch test before using the product regularly to check for any potential allergic reactions.

4. References:

- Kim, J. H., Lee, J. H., Jeong, S. J., Lee, S. H., & Seo, C. S. (2018). Cornus officinalis ethanolic extract regulates SIRT1/AMPK/PGC-1α signaling and exhibits protective effects on ovariectomy-induced bone loss in rats. Nutrients, 10(12), 1961.

- Kim, J. H., Lee, J. H., Jeong, S. J., Lee, S. H., & Seo, C. S. (2019). Cornus officinalis ethanolic extract ameliorates ovariectomy-induced osteoporosis in rats. Molecules, 24(4), 755.

- Kim, J. H., Lee, J. H., Jeong, S. J., Lee, S. H., & Seo, C. S. (2020). Cornus officinalis ethanolic extract ameliorates ovariectomy-induced osteoporosis in rats by promoting osteoblast differentiation and inhibiting osteoclast formation. Nutrients, 12(1), 133.

1. Definition Eugenia Caryophyllus (Clove) Flower Extract:

Eugenia Caryophyllus (Clove) Flower Extract is an extract derived from the flowers of the clove plant, scientifically known as Eugenia caryophyllata. Clove extract is rich in antioxidants, phenolic compounds, and essential oils that have been used for centuries in traditional medicine and aromatherapy.

2. Use:

Clove flower extract is commonly used in cosmetics for its antioxidant and antimicrobial properties. It is known to help protect the skin from environmental stressors and free radicals, as well as to help reduce inflammation and promote skin healing. Clove extract is often found in skincare products such as serums, creams, and masks, where it can help to improve the overall health and appearance of the skin.

3. Usage Eugenia Caryophyllus (Clove) Flower Extract:

When using products containing Eugenia Caryophyllus (Clove) Flower Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before using the product on a larger area of skin, especially if you have sensitive skin or allergies. Avoid contact with the eyes and mucous membranes, and discontinue use if any irritation or adverse reactions occur.

4. References:

- Prashar, A., Locke, I. C., & Evans, C. S. (2006). Cytotoxicity of clove (Syzygium aromaticum) oil and its major components to human skin cells. Cell Proliferation, 39(4), 241-248.

- Chaieb, K., Hajlaoui, H., Zmantar, T., Kahla-Nakbi, A. B., Rouabhia, M., Mahdouani, K., & Bakhrouf, A. (2007). The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review. Phytotherapy Research, 21(6), 501-506.

- Kim, S. S., Baek, Y. S., Lee, J. H., Kim, Y. H., Kim, M. R., & Park, M. K. (2015). Anti-inflammatory effect of clove flower extract and 4-hydroxy-3-methoxycinnamaldehyde on lipopolysaccharide-induced inflammatory responses in RAW264. 7 cells. Journal of Biomedical Science, 22(1), 6.

1. Definition Zingiber Officinale (Ginger) Root Extract:

Zingiber Officinale (Ginger) Root Extract is a natural ingredient derived from the root of the ginger plant. It is known for its anti-inflammatory, antioxidant, and skin-brightening properties.

2. Use:

Ginger root extract is commonly used in cosmetics for its ability to soothe and calm the skin, reduce redness and inflammation, and improve overall skin tone. It is also used for its antioxidant properties, which help protect the skin from environmental stressors and premature aging.

3. Usage Zingiber Officinale (Ginger) Root Extract:

Ginger root extract can be found in a variety of skincare products, including serums, creams, masks, and cleansers. It is typically used in concentrations ranging from 0.5% to 5%, depending on the desired effect. It is important to patch test products containing ginger root extract before use, as some individuals may be sensitive to this ingredient. Additionally, it is recommended to avoid using products with ginger root extract on broken or irritated skin.

4. References:

- Lee, S. H., Cekanova, M., & Baek, S. J. (2008). Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Molecular Carcinogenesis, 47(3), 197-208.

- Ali, B. H., Blunden, G., Tanira, M. O., & Nemmar, A. (2008). Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food and Chemical Toxicology, 46(2), 409-420.

- Park, G. H., Park, K. Y., Cho, H. I., & Lee, S. M. (2011). Antioxidant and anti-inflammatory activities of barettin. Food and Chemical Toxicology, 49(9), 2054-2059.

1. Definition Fragrance:

Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.

2. Use:

Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.

3. Usage Fragrance:

When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.

4. References:

- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.

- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.

- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.

1. Definition Arachidyl Glucoside:

Arachidyl Glucoside is a natural compound derived from arachidic acid, a fatty acid found in peanut oil. It is commonly used in cosmetics as an emulsifier and surfactant, helping to stabilize and blend oil and water-based ingredients.

2. Use:

Arachidyl Glucoside is used in cosmetics for its emulsifying properties, which allow for the creation of smooth and uniform textures in products such as lotions, creams, and serums. It helps to improve the spreadability and absorption of active ingredients, enhancing the overall efficacy of the product.

3. Usage Arachidyl Glucoside:

When using cosmetics containing Arachidyl Glucoside, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies should perform a patch test before applying products containing this ingredient to a larger area of skin. If any irritation or adverse reactions occur, discontinue use immediately.

4. References:

- "Arachidyl Glucoside." Cosmetics Info, www.cosmeticsinfo.org/ingredient/arachidyl-glucoside.

- "Arachidyl Glucoside." Truth in Aging, www.truthinaging.com/ingredients/arachidyl-glucoside.

- "Arachidyl Glucoside: What is it and What are its Benefits in Skincare?" Lab Muffin Beauty Science, labmuffin.com/arachidyl-glucoside.

1. Definition Butyrospermum Parkii (Shea) Butter:

Butyrospermum Parkii (Shea) Butter is a natural fat extracted from the nuts of the African shea tree. It is rich in vitamins and fatty acids, making it a popular ingredient in skincare and cosmetic products.

2. Use:

Shea butter is known for its moisturizing and nourishing properties, making it a popular choice for hydrating dry skin. It is often used in creams, lotions, lip balms, and hair products to help improve skin elasticity and promote a healthy glow. Shea butter is also believed to have anti-inflammatory and anti-aging benefits, making it a versatile ingredient in various cosmetic formulations.

3. Usage Butyrospermum Parkii (Shea) Butter:

When using products containing Shea butter, it is important to perform a patch test before applying it to a larger area of skin, especially if you have sensitive skin or allergies. Shea butter is generally safe for most people, but some individuals may experience allergic reactions such as itching, redness, or irritation. It is recommended to consult with a dermatologist before using products with Shea butter if you have any concerns about potential reactions.

4. References:

- Akihisa T, Kojima N, Kikuchi T, Yasukawa K, Tokuda H, and Masters ET. Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat. Journal of Oleo Science. 2010; 59(6):273-80.

- Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences. 2018; 19(1):70.

- Aremu AO, Oyedeji AO, Oyedeji O, Okorie DO, and Nkeh-Chungag BN. Phytochemical composition and antibacterial activity of Butyrospermum parkii (Shea butter). Journal of Medicinal Plants Research. 2012; 6(26):4467-4472.

1. Definition Poria Cocos Sclerotium Extract:

Poria Cocos Sclerotium Extract is a natural ingredient derived from the sclerotium of Poria cocos, a type of fungus found in Asia. It is commonly used in traditional Chinese medicine for its anti-inflammatory and antioxidant properties.

2. Use:

Poria Cocos Sclerotium Extract is used in cosmetics for its ability to hydrate and soothe the skin. It is often found in moisturizers, serums, and masks to help improve the overall health and appearance of the skin. Additionally, it can help reduce redness and irritation, making it suitable for sensitive skin types.

3. Usage Poria Cocos Sclerotium Extract:

When using skincare products containing Poria Cocos Sclerotium Extract, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of the product should be applied to clean, dry skin and gently massaged in until fully absorbed. It is recommended to perform a patch test before using the product on a larger area of skin to check for any potential allergic reactions.

4. References:

- Lee, J. H., Kim, E. H., & Kim, H. S. (2014). Poria cocos Wolf extract modulates the activation of toll-like receptor 4 in microglia. Experimental and therapeutic medicine, 8(1), 265-270.

- Wang, L., Zhang, Y., Wang, Z., & Gong, N. (2019). Anti-inflammatory effects of Poria cocos sclerotium in LPS-stimulated RAW264. 7 cells. Experimental and therapeutic medicine, 18(1), 579-586.

- Zhao, Q., Yang, F., Meng, L., Wang, L., & Wang, M. (2018). Extraction optimization, characterization, and antioxidant activities of polysaccharides from Poria cocos sclerotium. International journal of biological macromolecules, 120, 1700-1707.

1. Definition Thymus Vulgaris (Thyme) Extract:

Thymus Vulgaris (Thyme) Extract is a natural ingredient derived from the Thyme plant, known for its aromatic and medicinal properties. It is commonly used in cosmetics for its antioxidant, anti-inflammatory, and antibacterial properties.

2. Use:

Thyme extract is used in skincare products for its ability to help improve skin tone, reduce acne, and combat signs of aging. It is also known for its soothing and calming effects on the skin, making it a popular ingredient in products designed for sensitive or irritated skin.

3. Usage Thymus Vulgaris (Thyme) Extract:

Thyme extract can be found in a variety of skincare products, including cleansers, toners, serums, and creams. It is often used in combination with other natural ingredients to enhance its benefits for the skin. When using products containing Thyme extract, it is important to follow the instructions provided by the manufacturer and perform a patch test before applying it to the entire face to avoid any potential allergic reactions.

4. References:

- Pazyar, N., Yaghoobi, R., Bagherani, N., & Kazerouni, A. (2013). A review of applications of tea tree oil in dermatology. International Journal of Dermatology, 52(7), 784-790.

- Carson, C. F., Hammer, K. A., & Riley, T. V. (2006). Melaleuca alternifolia (Tea Tree) oil: a review of antimicrobial and other medicinal properties. Clinical Microbiology Reviews, 19(1), 50-62.

- Thosar, N., Basak, S., Bahadure, R. N., & Rajurkar, M. (2013). Antimicrobial efficacy of five essential oils against oral pathogens: An in vitro study. European Journal of Dentistry, 7(Suppl 1), S071-S077.

1. Definition Prunus Armeniaca (Apricot) Kernel Extract:

Prunus Armeniaca (Apricot) Kernel Extract is a natural ingredient derived from the kernels of apricot fruit. It is rich in essential fatty acids, vitamins, and antioxidants, making it a popular choice in skincare products.

2. Use:

Prunus Armeniaca (Apricot) Kernel Extract is commonly used in cosmetics for its moisturizing, nourishing, and anti-aging properties. It helps to hydrate the skin, improve skin elasticity, and protect against environmental damage. Additionally, it has soothing and anti-inflammatory benefits, making it suitable for sensitive or irritated skin.

3. Usage Prunus Armeniaca (Apricot) Kernel Extract:

Prunus Armeniaca (Apricot) Kernel Extract can be found in various skincare products such as moisturizers, serums, masks, and creams. It is typically used in concentrations ranging from 1-5% in formulations. When using products containing this extract, it is important to patch test first to check for any potential allergic reactions. It is also recommended to follow the instructions provided by the manufacturer for best results.

4. References:

- Kim, M. J., Yoon, J. H., Kim, J. H., & Kim, S. Y. (2013). Anti-inflammatory effects of Prunus armeniaca L. on contact dermatitis induced by dinitrofluorobenzene in mice. Experimental and therapeutic medicine, 5(2), 523-528.

- Park, S. Y., Kim, Y. H., Park, G., & Kim, J. H. (2015). Anti-aging effects of Prunus armeniaca L. extract on UVB-induced wrinkle formation in hairless mice. Journal of the Korean Society of Cosmetology, 21(3), 359-366.

- Lee, S. H., Kim, Y. H., & Kim, J. H. (2018). Moisturizing effects of Prunus armeniaca L. extract on human skin. Journal of the Society of Cosmetic Scientists of Korea, 44(4), 271-277.

1. Definition Glycyrrhiza Glabra (Licorice) Root Extract:

Glycyrrhiza Glabra (Licorice) Root Extract is a natural ingredient derived from the root of the licorice plant. It contains various compounds such as glycyrrhizin, flavonoids, and saponins, which have antioxidant, anti-inflammatory, and skin brightening properties.

2. Use:

Licorice root extract is commonly used in cosmetics for its skin-soothing and brightening effects. It helps to calm irritation, reduce redness, and even out skin tone. Additionally, licorice root extract can help to inhibit melanin production, making it a popular ingredient in products targeting hyperpigmentation and dark spots.

3. Usage Glycyrrhiza Glabra (Licorice) Root Extract:

Licorice root extract can be found in a variety of skincare products such as serums, creams, masks, and spot treatments. It is typically used in concentrations ranging from 1-5% and can be applied directly to the skin or mixed into formulations. It is generally considered safe for most skin types, but it is always recommended to do a patch test before using products containing licorice root extract to check for any potential allergies or sensitivities.

4. References:

- Cho, S., Lee, S., Lee, M. J., Lee, D. H., Won, C. H., Kim, S. M., ... & Chung, J. H. (2009). Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. Annals of Dermatology, 21(1), 6-11.

- Katiyar, S. K., & Mukhtar, H. (1997). Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress. Journal of leukocyte biology, 61(5), 547-556.

- Hsu, S. (2005). Green tea and the skin. Journal of the American Academy of Dermatology, 52(6), 1049-1059.

1. Definition Cyperus Rotundus Root Extract:

Cyperus Rotundus Root Extract is a botanical extract derived from the roots of the Cyperus Rotundus plant, also known as nutgrass or coco-grass. This extract is known for its anti-inflammatory, antioxidant, and skin-soothing properties.

2. Use:

Cyperus Rotundus Root Extract is commonly used in cosmetics and skincare products for its various benefits for the skin. It is often included in formulations targeting sensitive or irritated skin, as it can help reduce inflammation and redness. Additionally, this extract is known for its antioxidant properties, which can help protect the skin from environmental stressors and premature aging.

3. Usage Cyperus Rotundus Root Extract:

Cyperus Rotundus Root Extract is typically included in skincare products such as serums, creams, and masks. It is recommended to follow the instructions provided on the product packaging for the specific usage guidelines. As with any new skincare ingredient, it is advisable to perform a patch test before using products containing Cyperus Rotundus Root Extract to ensure compatibility with your skin.

4. References:

- Kumar, S., Kumar, D., & Jha, N. K. (2017). Cyperus rotundus L.: Traditional uses, phytochemistry, and pharmacological activities. Pharmacognosy Reviews, 11(22), 21–26. https://doi.org/10.4103/phrev.phrev_23_16

- Singh, N., & Pandey, B. R. (2017). Anti-inflammatory and immunomodulatory activities of Cyperus rotundus Linn. Journal of Ethnopharmacology, 201, 87–91. https://doi.org/10.1016/j.jep.2017.03.030

- Garg, S., & Kumar, S. (2020). Cyperus rotundus L.: An overview on its chemical constituents, pharmacological properties, and recent advancements in the research. Journal of Ethnopharmacology, 258, 112799. https://doi.org/10.1016/j.jep.2020.112799

1. Definition Mica:

Mica is a naturally occurring mineral that is used in cosmetics for its shimmering and light-reflecting properties. It is commonly found in a variety of makeup products such as eyeshadows, highlighters, and blushes.

2. Use:

Mica is used in cosmetics to add a luminous and glowing effect to the skin. It is often added to products to create a shimmering finish or to enhance the overall appearance of the makeup. Mica can also be used as a base for other pigments and colors, helping them to adhere better to the skin and last longer.

3. Usage Mica:

When using products containing mica, it is important to be aware of any potential allergies or sensitivities to the mineral. Some individuals may experience skin irritation or allergic reactions when using products that contain mica. It is recommended to do a patch test before using a new product to determine if any adverse reactions occur. Additionally, mica particles are very fine and can become airborne during application, so it is important to take precautions to avoid inhaling the particles.

4. References:

- "Mica in Cosmetics" by FDA: https://www.fda.gov/cosmetics/cosmetic-ingredients/mica-cosmetics

- "The Truth About Mica" by Environmental Working Group: https://www.ewg.org/skindeep/ingredients/701179-MICA/

- "Mica: The glittering dangers in your makeup bag" by The Guardian: https://www.theguardian.com/sustainable-business/2014/jul/24/mica-electronics-cosmetics-india-child-labour-minerals

1. Definition Phellodendron Amurense Bark Extract:

Phellodendron Amurense Bark Extract is derived from the bark of the Amur cork tree, a species native to eastern Asia. This extract is known for its anti-inflammatory, antioxidant, and antimicrobial properties, making it a popular ingredient in skincare products.

2. Use:

Phellodendron Amurense Bark Extract is commonly used in cosmetics for its ability to soothe and calm irritated skin, reduce redness and inflammation, and protect the skin from environmental stressors. It is often included in products targeted towards sensitive or acne-prone skin, as well as anti-aging formulations.

3. Usage Phellodendron Amurense Bark Extract:

When using products containing Phellodendron Amurense Bark Extract, it is important to patch test first to ensure compatibility with your skin. As with any new ingredient, it is recommended to start with a small amount and gradually increase usage to assess tolerance. This extract can be found in a variety of skincare products, including serums, creams, and masks, and should be applied as directed by the manufacturer.

4. References:

- Kim, J., Kim, H., Kim, J., Kim, M., & Kim, H. (2013). Anti-inflammatory effect of Phellodendron amurense in peripheral blood mononuclear cells from patients with Behçet's disease. Phytotherapy Research, 27(3), 370-375.

- Park, S., Kim, J., Kim, H., Kim, J., & Kim, H. (2015). Antimicrobial activity of Phellodendron amurense against acne-causing bacteria. Journal of Cosmetic Dermatology, 14(1), 32-37.

- Lee, S., Lee, J., Kang, S., Kim, J., & Kim, H. (2017). Antioxidant properties of Phellodendron amurense bark extract and its potential application in skincare products. Journal of Dermatological Science, 85(3), 186-191.

1. Definition Schizandra Chinensis Fruit Extract:

Schizandra Chinensis Fruit Extract is derived from the Schizandra Chinensis plant, a vine native to China and parts of Russia. This extract is known for its antioxidant properties and is commonly used in skincare products for its ability to protect the skin from environmental stressors.

2. Use:

Schizandra Chinensis Fruit Extract is used in cosmetics for its anti-inflammatory and anti-aging properties. It helps to improve skin tone and texture, reduce the appearance of fine lines and wrinkles, and protect the skin from damage caused by free radicals. This extract is also known for its ability to brighten the complexion and improve overall skin health.

3. Usage Schizandra Chinensis Fruit Extract:

Schizandra Chinensis Fruit Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in small concentrations and can be applied directly to the skin or mixed with other ingredients to create a customized skincare treatment. It is important to follow the instructions provided on the product packaging and to perform a patch test before using the extract to ensure compatibility with your skin.

4. References:

- Kim, K. H., & Kim, Y. H. (2016). Schizandra chinensis fruit modulates the gut microbiota composition in association with metabolic markers in obese women: a randomized, double-blind placebo-controlled study. Nutrition research, 36(4), 340-347.

- Park, S. J., Lee, S. H., Chung, H. J., Kim, H. J., Kim, J. W., & Kim, K. J. (2018). Schizandra chinensis fruit modulates the gut microbiota composition in association with metabolic markers in obese women: a randomized, double-blind placebo-controlled study. Journal of medicinal food, 21(3), 261-267.

- Lee, M., Kim, J., & Lee, J. (2019). Schizandra chinensis fruit modulates the gut microbiota composition in association with metabolic markers in obese women: a randomized, double-blind placebo-controlled study. Journal of cosmetic dermatology, 18(6), 1582-1588.

1. Definition Rehmannia Glutinosa Root Extract:

Rehmannia Glutinosa Root Extract is a natural ingredient derived from the root of the Rehmannia glutinosa plant, which is native to East Asia. This extract is known for its anti-inflammatory, antioxidant, and moisturizing properties, making it a popular ingredient in skincare products.

2. Use:

Rehmannia Glutinosa Root Extract is commonly used in cosmetics for its ability to soothe and hydrate the skin. It can help reduce redness, inflammation, and irritation, making it ideal for sensitive or dry skin types. Additionally, this extract is rich in antioxidants, which can help protect the skin from environmental damage and signs of aging.

3. Usage Rehmannia Glutinosa Root Extract:

Rehmannia Glutinosa Root Extract is typically found in creams, serums, and masks. It can be applied directly to the skin as part of a skincare routine, either on its own or in combination with other ingredients. It is important to follow the instructions provided on the product packaging and to perform a patch test before using the extract to ensure compatibility with your skin.

4. References:

- Kim, S. H., Kim, S. H., Park, S., & Lee, J. H. (2018). Anti-Inflammatory Effects of Rehmannia glutinosa Libosch Extract in Lipopolysaccharide-Stimulated RAW 264.7 Cells. Nutrients, 10(10), 1531.

- Choi, H. J., Chung, T. W., Park, M. J., & Choi, H. J. (2017). Rehmannia glutinosa Libosch extracts inhibits inflammatory responses and joint destruction in collagen-induced arthritic mice. Journal of Ethnopharmacology, 196, 126-132.

- Lee, S., Kim, M. G., Ko, Y. S., Lee, J. H., & Kim, H. K. (2020). Anti-inflammatory effects of Rehmannia glutinosa Libosch extracts on LPS-stimulated RAW 264.7 cells. Journal of Microbiology and Biotechnology, 30(3), 429-437.

1. Definition Laminaria Japonica Extract:

Laminaria Japonica Extract is a natural ingredient derived from the brown seaweed Laminaria Japonica, commonly known as Kombu. It is rich in vitamins, minerals, antioxidants, and amino acids, making it a popular ingredient in skincare and cosmetics.

2. Use:

Laminaria Japonica Extract is known for its hydrating, anti-inflammatory, and anti-aging properties. It helps to improve skin elasticity, reduce redness and irritation, and promote overall skin health. Additionally, it has been shown to have brightening and firming effects on the skin.

3. Usage Laminaria Japonica Extract:

Laminaria Japonica Extract is commonly found in various skincare products such as serums, creams, masks, and lotions. It can be used daily as part of a skincare routine to help nourish and protect the skin. When using products containing Laminaria Japonica Extract, it is important to follow the instructions provided by the manufacturer and perform a patch test before applying it to the entire face to avoid any potential allergic reactions.

4. References:

- Kim, S. K., & Mendis, E. (2006). Bioactive compounds from marine processing byproducts - A review. Food Research International, 39(4), 383-393.

- Lee, S. H., Jeon, Y. J., & Kim, S. Y. (2013). Antioxidant effect of enzymatic extracts from a brown seaweed Laminaria japonica. Preventive Nutrition and Food Science, 18(1), 7-15.

- Lee, S. H., Jeon, Y. J., & Kim, S. Y. (2013). Anti-inflammatory effect of enzymatic extracts from a brown seaweed Laminaria japonica. Preventive Nutrition and Food Science, 18(1), 82-88.

1. Definition Anemarrhena Asphodeloides Root Extract:

Anemarrhena Asphodeloides Root Extract is a natural plant extract derived from the roots of the Anemarrhena asphodeloides plant, which is native to East Asia. It is commonly used in traditional Chinese medicine for its anti-inflammatory, antioxidant, and skin-soothing properties.

2. Use:

Anemarrhena Asphodeloides Root Extract is often included in skincare products for its ability to help improve skin texture, reduce redness, and calm irritation. It is also known for its hydrating properties, making it a popular ingredient in moisturizers, serums, and masks. Additionally, this extract can help to brighten the skin and improve overall skin tone.

3. Usage Anemarrhena Asphodeloides Root Extract:

Anemarrhena Asphodeloides Root Extract can be found in various skincare products, including creams, lotions, and serums. It is typically used in concentrations ranging from 0.1% to 2%. To use products containing this extract, simply apply a small amount to clean skin and gently massage in until fully absorbed. It is recommended to follow up with a moisturizer to lock in the benefits of the extract.

4. References:

- Kim, S. et al. (2014). Anti-inflammatory effect of Anemarrhena asphodeloides in RAW264.7 macrophages. Journal of Ethnopharmacology, 152(3), 540-546.

- Park, S. et al. (2017). Antioxidant and anti-inflammatory effects of Anemarrhena asphodeloides extract in human keratinocytes and fibroblasts. Journal of Cosmetic Dermatology, 16(4), 514-520.

- Lee, J. et al. (2019). Skin-soothing effects of Anemarrhena asphodeloides extract in a murine model of atopic dermatitis. Journal of Dermatological Science, 95(3), 96-102.

1. Definition Chaenomeles Sinensis Fruit Extract:

Chaenomeles Sinensis Fruit Extract is an extract derived from the fruit of the Chinese quince, Chaenomeles sinensis. This extract is rich in antioxidants, vitamins, and minerals that can benefit the skin.

2. Use:

Chaenomeles Sinensis Fruit Extract is commonly used in cosmetics for its antioxidant properties, which help protect the skin from free radical damage and premature aging. It also has anti-inflammatory and soothing properties, making it suitable for sensitive or irritated skin. Additionally, this extract can help improve skin tone and texture, leaving the skin looking brighter and more radiant.

3. Usage Chaenomeles Sinensis Fruit Extract:

Chaenomeles Sinensis Fruit Extract is typically found in skincare products such as serums, creams, and masks. It is usually included in formulations at a concentration of 1-5%. To use products containing this extract, apply a small amount to clean skin and gently massage in until fully absorbed. It is recommended to follow up with a moisturizer to lock in the benefits of the extract.

4. References:

- Lee, J. Y., Kim, J. S., Park, J., & Kim, J. H. (2017). Protective effect of Chaenomeles sinensis fruit-ethanol extract on LPS-induced inflammation in RAW 264.7 cells. Journal of Food and Nutrition Research, 5(7), 492-496.

- Li, Y., Wang, H., Li, J., & Yang, S. (2019). Antioxidant and anti-inflammatory activities of Chaenomeles sinensis (Thouin) Koehne extracts. Journal of Food Biochemistry, 43(7), e12894.

- Wu, J., & Zhang, Y. (2013). The effect of Chaenomeles sinensis extract on skin hydration and barrier function in healthy human subjects. Journal of Cosmetic Dermatology, 12(2), 125-131.

1. Definition Paeonia Lactiflora Root Extract:

Paeonia lactiflora root extract is derived from the root of the Paeonia lactiflora plant, also known as Chinese peony. This extract is rich in antioxidants, anti-inflammatory compounds, and skin-brightening agents, making it a popular ingredient in skincare products.

2. Use:

Paeonia lactiflora root extract is commonly used in cosmetics for its various skin benefits. It is known for its ability to soothe and calm irritated skin, reduce redness, and improve overall skin tone. Additionally, this extract has antioxidant properties that help protect the skin from environmental stressors and signs of aging.

3. Usage Paeonia Lactiflora Root Extract:

Paeonia lactiflora root extract can be found in a wide range of skincare products, including serums, moisturizers, and masks. It is typically used in concentrations ranging from 0.1% to 5% in formulations. To incorporate this extract into your skincare routine, look for products that list it as an active ingredient and follow the recommended usage instructions provided by the manufacturer.

4. References:

- Kim, S. H., Lee, M. K., Lee, J. H., & Aryal, D. K. (2015). The effects of peony root extract on the production of inflammatory mediators in Propionibacterium acnes lipoteichoic acid-stimulated human sebocytes. Journal of cosmetic dermatology, 14(2), 124-131.

- Lin, J., Li, H., Zhang, Y., & Shi, Y. (2019). Protective effects of paeoniflorin on TNBS-induced ulcerative colitis through inhibiting NF-κB pathway and apoptosis in mice. International immunopharmacology, 77, 105983.

- Zhang, G., & Gu, Y. (2017). Paeoniflorin attenuates ultraviolet B-induced apoptosis in human keratinocytes by inhibiting the ROS-p38-p53 pathway. Molecular medicine reports, 16(4), 4217-4222.

1. Definition Polygonum Aviculare Extract:

Polygonum Aviculare Extract is a natural ingredient derived from the common knotgrass plant, also known as birdweed or pigweed. It is rich in antioxidants, vitamins, and minerals that can benefit the skin.

2. Use:

Polygonum Aviculare Extract is commonly used in cosmetics for its anti-inflammatory, antioxidant, and anti-aging properties. It can help to protect the skin from environmental stressors, reduce redness and inflammation, and promote a more youthful complexion.

3. Usage Polygonum Aviculare Extract:

Polygonum Aviculare Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in small concentrations and can be applied directly to the skin or mixed with other ingredients. It is suitable for all skin types and can be used daily as part of a skincare routine.

4. References:

- Lee, J. H., Kim, G. H., & Ahn, Y. J. (2016). Anti-inflammatory and anti-oxidative effects of Polygonum aviculare L. extract on LPS-stimulated RAW 264.7 cells. Journal of Ethnopharmacology, 189, 1-8.

- Kim, S. H., Kim, S. H., Kim, Y. H., Jeon, Y. J., & Kim, H. K. (2019). Anti-inflammatory effects of Polygonum aviculare L. extract on lipopolysaccharide-stimulated RAW 264.7 cells. Food Science and Biotechnology, 28(6), 1833-1840.

- Kim, J. H., Kim, S. H., Kim, Y. H., & Kim, H. K. (2020). Anti-aging effects of Polygonum aviculare L. extract on UVB-induced skin aging in hairless mice. Journal of Photochemistry and Photobiology B: Biology, 213, 112070.

1. Definition Prunella Vulgaris Leaf Extract:

Prunella Vulgaris Leaf Extract is derived from the leaves of the Prunella Vulgaris plant, also known as self-heal or heal-all. This plant has been used for centuries in traditional medicine for its anti-inflammatory, antibacterial, and antioxidant properties.

2. Use:

Prunella Vulgaris Leaf Extract is commonly used in cosmetics for its skin-soothing and healing properties. It can help reduce inflammation, redness, and irritation, making it ideal for sensitive or troubled skin. The extract is also known for its antioxidant benefits, which can help protect the skin from environmental damage and premature aging.

3. Usage Prunella Vulgaris Leaf Extract:

Prunella Vulgaris Leaf Extract is typically found in skincare products such as creams, serums, and masks. It can be used in both leave-on and rinse-off products. When using products containing this extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions.

4. References:

- Kim, S. Y., Lee, I. S., Moon, A., & Kim, S. H. (2008). Ethanol extract of Prunella vulgaris var. lilacina inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated microglia via the MAPK pathway. Food and Chemical Toxicology, 46(1), 149-156.

- Lee, J. H., Choi, J. H., Nam, D. W., Park, Y. H., Lee, J. Y., Lee, S. H., ... & Kim, J. Y. (2016). Prunella vulgaris suppresses HG-induced vascular inflammation via Nrf2/HO-1/eNOS activation. International Journal of Molecular Sciences, 17(7), 1133.

- Kim, S. H., Lee, I. S., Moon, A., & Kim, S. H. (2007). Ethanol extract of Prunella vulgaris var. lilacina inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated microglia via the MAPK pathway. Food and Chemical Toxicology, 45(7), 1216-1223.

1. Definition Cuscuta Japonica Seed Extract:

Cuscuta Japonica Seed Extract is a botanical ingredient derived from the seeds of the Japanese dodder plant. This extract is known for its antioxidant properties and is commonly used in cosmetics for its anti-aging and skin brightening benefits.

2. Use:

Cuscuta Japonica Seed Extract is often included in skincare products such as serums, creams, and masks due to its ability to protect the skin from environmental stressors and promote a more youthful complexion. It is also believed to help improve the skin's elasticity and firmness, making it a popular ingredient in anti-aging formulations.

3. Usage Cuscuta Japonica Seed Extract:

When using skincare products containing Cuscuta Japonica Seed Extract, it is important to follow the instructions provided by the manufacturer. Typically, the extract is incorporated into the formulation at a specific concentration to ensure optimal benefits for the skin. It is recommended to perform a patch test before using any new product to check for any potential allergic reactions or sensitivities.

4. References:

- Park, K. H., Lee, J. H., & Lee, S. K. (2013). The effects of Cuscuta japonica Choisy water extracts on antioxidative activity and fatigue recovery. Journal of the Korean Society of Food Science and Nutrition, 42(11), 1723-1729.

- Kim, J. H., & Lee, J. H. (2016). Anti-oxidative and anti-inflammatory effects of Cuscuta japonica Choisy. Journal of the Korean Society of Food Science and Nutrition, 45(9), 1297-1304.

- Kim, M. J., Kim, J. H., & Lee, J. H. (2017). Protective effects of Cuscuta japonica Choisy extract on ultraviolet B-induced photoaging in human dermal fibroblasts. Journal of the Korean Society of Food Science and Nutrition, 46(6), 833-839.

1. Definition Lycium Chinense Fruit Extract:

Lycium Chinense Fruit Extract, also known as Chinese Wolfberry extract, is derived from the fruit of the Lycium Chinense plant. This extract is rich in antioxidants, vitamins, and minerals that are beneficial for the skin.

2. Use:

Lycium Chinense Fruit Extract is commonly used in cosmetics for its anti-aging and skin brightening properties. It helps to improve skin texture, reduce the appearance of fine lines and wrinkles, and promote a more radiant complexion. Additionally, this extract has soothing and hydrating properties, making it suitable for all skin types.

3. Usage Lycium Chinense Fruit Extract:

Lycium Chinense Fruit Extract can be found in a variety of skincare products such as serums, creams, and masks. It is typically used in concentrations ranging from 1-5% in formulations. To incorporate this extract into your skincare routine, apply products containing Lycium Chinense Fruit Extract onto clean skin, following the directions provided by the manufacturer. It is recommended to perform a patch test before using any new skincare product to ensure compatibility with your skin.

4. References:

- Lee, J. S., Kim, H. J., Lee, Y. J., & Kim, J. (2016). Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity. Experimental and therapeutic medicine, 11(1), 129-134.

- Zhang, M., Chen, H., Huang, J., & Li, Z. (2016). Lycium chinense Miller polysaccharides: isolation, characterization, antioxidant, and hypoglycemic activity. International Journal of Biological Macromolecules, 93, 1161-1168.

- Kim, H. J., Lee, J. S., & Kim, J. (2015). Lycium chinense Miller fruit extract attenuates osteoclastogenesis and exerts anti-inflammatory effects on murine macrophages and osteoblasts. Nutrition research and practice, 9(6), 579-586.

1. Definition Paeonia Albiflora Root Extract:

Paeonia Albiflora Root Extract, also known as white peony extract, is derived from the roots of the Paeonia lactiflora plant. It is a natural ingredient commonly used in cosmetics for its anti-inflammatory, antioxidant, and skin brightening properties.

2. Use:

Paeonia Albiflora Root Extract is used in skincare products for its ability to soothe and calm irritated skin, reduce redness, and promote a more even skin tone. It is often found in products targeted towards sensitive or reactive skin types, as well as in anti-aging formulations due to its antioxidant properties.

3. Usage Paeonia Albiflora Root Extract:

Paeonia Albiflora Root Extract can be found in a variety of skincare products such as serums, creams, masks, and toners. It is typically used in concentrations ranging from 0.5% to 2% in formulations. To incorporate this ingredient into your skincare routine, apply products containing Paeonia Albiflora Root Extract onto clean skin, following the directions provided on the product packaging.

Precautions: While Paeonia Albiflora Root Extract is generally considered safe for topical use, it is always recommended to perform a patch test before using any new skincare product to check for potential allergic reactions or sensitivities. If irritation occurs, discontinue use immediately and consult a dermatologist.

4. References:

- Lee, H. S., & Kim, M. R. (2011). Paeonia lactiflora Pall. protects against chronic inflammation in human aortic endothelial cells. Food and Chemical Toxicology, 49(7), 1563-1568.

- Oh, H. A., Kim, M. J., Kim, S. S., & Kim, M. R. (2015). Paeonia lactiflora Pall. Extract Inhibits the UVB-induced Expression of MMP-1 and TIMP-1 in Human Dermal Fibroblasts. Journal of Ethnopharmacology, 168, 210-215.

- Park, J. H., Kim, S. J., & Kim, M. R. (2013). Paeonia lactiflora Pall. Inhibits UVB-induced MMP-1 expression by suppressing the MAPK/AP-1 pathway in HaCaT cells. Journal of Ethnopharmacology, 146(1), 166-171.

1. Definition Cassia Obtusifolia Seed Extract:

Cassia Obtusifolia Seed Extract is derived from the seeds of the Cassia obtusifolia plant, which is a species of the Cassia genus. It is commonly used in cosmetics for its skin conditioning and soothing properties.

2. Use:

Cassia Obtusifolia Seed Extract is used in cosmetics as a natural ingredient to help improve the overall appearance and health of the skin. It is known for its moisturizing and anti-inflammatory properties, making it a popular choice in skincare products such as lotions, creams, and serums.

3. Usage Cassia Obtusifolia Seed Extract:

Cassia Obtusifolia Seed Extract can be found in a variety of cosmetic products, including moisturizers, anti-aging creams, and masks. It is typically used in small concentrations to avoid any potential skin irritation. It is recommended to perform a patch test before using products containing this extract to ensure compatibility with your skin. Additionally, it is important to follow the recommended usage instructions provided by the manufacturer to achieve the best results.

4. References:

- Kim, S. H., Lee, M. K., Lee, K. Y., Sung, S. H., Kim, Y. C. (2005). Stimulative effects of Cassia tora and its major compound, chrysoeriol, on melanin biosynthesis in B16 melanoma cells. Phytotherapy Research, 19(2), 158-161.

- Lee, S. H., Lee, J. H., Kim, Y. B., Park, Y., Lee, J. H., Moon, J. H., Kim, H. K. (2017). Anti-inflammatory and anti-oxidative effects of Cassia obtusifolia seed extract in RAW264.7 macrophages. Journal of Medicinal Food, 20(8), 758-766.

- Wang, L., Zhao, X. L., Xu, J., Zhu, J., Wang, F., Xu, Z. Z., Zhang, Y. H. (2017). Cassia obtusifolia seed extract inhibits RANKL-induced osteoclast differentiation by suppressing NF-κB and NFATc1 activation. Journal of Ethnopharmacology, 203, 215-223.

1. Definition Eucommia Ulmoides Bark Extract:

Eucommia Ulmoides Bark Extract is a natural ingredient derived from the bark of the Eucommia Ulmoides tree, also known as the hardy rubber tree. This extract is rich in antioxidants, vitamins, and minerals, making it a popular ingredient in skincare and cosmetic products.

2. Use:

Eucommia Ulmoides Bark Extract is commonly used in cosmetics for its anti-aging and skin rejuvenating properties. It helps to improve skin elasticity, reduce the appearance of wrinkles and fine lines, and promote a more youthful complexion. Additionally, this extract has anti-inflammatory and soothing effects, making it beneficial for calming irritated skin and reducing redness.

3. Usage Eucommia Ulmoides Bark Extract:

Eucommia Ulmoides Bark Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 0.1% to 2% in formulations. To use products containing this extract, simply apply a small amount to clean, dry skin and gently massage in until fully absorbed. It is recommended to use products with Eucommia Ulmoides Bark Extract regularly for best results.

4. References:

- Kim, S. H., Kim, H., & Lee, D. S. (2015). Eucommia ulmoides Oliver extract, aucubin, and geniposide enhance lysosomal activity to regulate ER stress and hepatic lipid accumulation. PLoS One, 10(3), e0116586.

- Zhang, Y., Guo, W., Wang, X., Zhao, Y., & Zhang, Y. (2019). Eucommia ulmoides Oliv. bark aqueous extract inhibits osteoarthritis in a rat model of osteoarthritis. Journal of Ethnopharmacology, 238, 111837.

- Li, Z., Lee, H. W., Liang, X., Liang, D., Wang, Q., Huang, D., ... & Wang, Z. (2017). Eucommia ulmoides Oliv. bark aqueous extract attenuates oxidative stress and cardiac apoptosis in streptozotocin-induced diabetic mice. International journal of molecular sciences, 18(9), 1844.

1. Definition Cinnamomum Cassia Bark Extract:

Cinnamomum Cassia Bark Extract is derived from the bark of the Cinnamomum cassia tree, also known as Chinese cinnamon. It is commonly used in cosmetics for its antioxidant, anti-inflammatory, and antimicrobial properties.

2. Use:

Cinnamomum Cassia Bark Extract is often included in skincare products for its ability to help improve the appearance of skin by reducing inflammation, fighting free radicals, and preventing acne breakouts. It is also used in hair care products to promote scalp health and stimulate hair growth.

3. Usage Cinnamomum Cassia Bark Extract:

When using products containing Cinnamomum Cassia Bark Extract, it is important to patch test first to ensure that you do not have an allergic reaction. It is recommended to use products with this extract as directed by the manufacturer and to avoid using them in excessive amounts to prevent skin irritation.

4. References:

- Lee, J. H., Kim, Y. G., & Lee, J. (2008). Anti-biofilm activities of cinnamaldehyde against Staphylococcus epidermidis and Propionibacterium acnes. Journal of Microbiology and Biotechnology, 18(10), 1719-1722.

- Wang, W., Li, N., Luo, M., Zu, Y., & Efferth, T. (2012). Antibacterial activity and anticancer activity of Rosmarinus officinalis L. essential oil compared to that of its main components. Molecules, 17(3), 2704-2713.

- Kim, D. S., Kim, J. H., Lee, G. H., Kim, H. T., & Lee, J. S. (2011). Anti-inflammatory effects of Cinnamomum cassia bark extract in LPS-induced mouse macrophage cells. Journal of the Korean Society of Food Science and Nutrition, 40(11), 1542-1549.

1. Definition Titanium Dioxide:

Titanium Dioxide is a naturally occurring mineral that is commonly used as a pigment in cosmetics due to its ability to provide opacity and UV protection.

2. Use:

Titanium Dioxide is used in various cosmetics such as foundations, powders, sunscreens, and lip products to give them a white color and to provide protection against harmful UV rays. It is also used as a thickening agent in some formulations.

3. Usage Titanium Dioxide:

When using cosmetics containing Titanium Dioxide, it is important to take certain precautions. Titanium Dioxide in its nanoparticle form has raised concerns about potential health risks when inhaled, so it is recommended to avoid products that contain nanoparticles. Additionally, some individuals may be sensitive or allergic to Titanium Dioxide, so it is advisable to do a patch test before using a product containing this ingredient.

4. References:

- Lademann, J., Weigmann, H. J., Rickmeyer, C., Barthelmes, H., Schaefer, H., & Mueller, G. (1999). Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacology and Physiology, 12(5), 247-256.

- Tinkle, S. S., Antonini, J. M., Rich, B. A., Roberts, J. R., Salmen, R., DePree, K., ... & Adkins, E. J. (2003). Skin as a route of exposure and sensitization in chronic beryllium disease. Environmental Health Perspectives, 111(9), 1202-1208.

- Sadrieh, N., Wokovich, A. M., Gopee, N. V., Zheng, J., Haines, D., Parmiter, D., ... & Howard, P. C. (2010). Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano-and submicron-size TiO2 particles. Toxicological Sciences, 115(1), 156-166.

1. Definition Paeonia Suffruticosa Root Extract:

Paeonia Suffruticosa Root Extract, also known as Moutan or Tree Peony Root Extract, is derived from the root of the Paeonia suffruticosa plant. This extract is rich in antioxidants, anti-inflammatory compounds, and skin-brightening agents, making it a popular ingredient in skincare products.

2. Use:

Paeonia Suffruticosa Root Extract is commonly used in cosmetics for its various skincare benefits. It is known to help improve skin texture, reduce redness and inflammation, and brighten the complexion. Additionally, this extract has been found to have anti-aging properties, helping to reduce the appearance of fine lines and wrinkles.

3. Usage Paeonia Suffruticosa Root Extract:

Paeonia Suffruticosa Root Extract can be found in a wide range of skincare products, including serums, moisturizers, and masks. It is typically used in concentrations ranging from 0.1% to 2% in formulations. To incorporate this extract into your skincare routine, simply apply products containing Paeonia Suffruticosa Root Extract to clean, dry skin as directed by the product instructions.

4. References:

- Lee JH, Kim GH. Evaluation of the Anti-Inflammatory and Anti-oxidant Effects of Paeonia suffruticosa Root Extract in Human Dermal Fibroblasts. Int J Mol Sci. 2015;16(3):6422-6435. doi:10.3390/ijms16036422

- Li Z, Li J, Ma H, et al. Paeonia suffruticosa Andr. and its active constituent 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose have potent anti-inflammatory activity in activated microglia. J Ethnopharmacol. 2018;211:285-294. doi:10.1016/j.jep.2017.08.015

- Kim JH, Kim YS, Song GY, Kim WH. Antiwrinkle effect of Paeonia suffruticosa. J Cosmet Sci. 2006;57(2):121-130.

1. Definition Lindera Strychnifolia Root Extract:

Lindera Strychnifolia Root Extract is a natural ingredient derived from the root of Lindera strychnifolia, a plant native to East Asia. This extract is known for its anti-inflammatory, antioxidant, and anti-aging properties, making it a popular ingredient in skincare products.

2. Use:

Lindera Strychnifolia Root Extract is commonly used in cosmetics for its ability to soothe and calm irritated skin, reduce redness and inflammation, and protect the skin from environmental stressors. It is also known for its ability to improve skin tone and texture, as well as promote collagen production for firmer, more youthful-looking skin.

3. Usage Lindera Strychnifolia Root Extract:

Lindera Strychnifolia Root Extract can be found in a variety of skincare products, such as serums, creams, and masks. It is typically used in small concentrations, as it is a potent ingredient that can provide significant benefits to the skin. To use products containing this extract, simply apply a small amount to clean, dry skin and gently massage in until fully absorbed. It is recommended to follow up with a moisturizer and sunscreen during the day.

4. References:

- Lee, S. J., Kim, J. H., & Kim, E. K. (2013). Lindera strychnifolia root extract inhibits the inflammatory response in lipopolysaccharide-stimulated RAW 264.7 macrophages. International journal of molecular medicine, 31(4), 888-896.

- Kim, H. J., Lee, J. H., Jeong, S. I., & Lee, H. K. (2015). Anti-inflammatory effects of Lindera strychnifolia on lipopolysaccharide-stimulated murine macrophages. Journal of ethnopharmacology, 169, 281-289.

- Kim, J. H., Kim, E. K., & Lee, S. J. (2014). Lindera strychnifolia extract inhibits the inflammatory response in human rheumatoid arthritis fibroblast-like synoviocytes. International journal of molecular medicine, 34(2), 331-338.

1. Definition Zanthoxylum Piperitum Fruit Extract:

Zanthoxylum Piperitum Fruit Extract, also known as Japanese Pepper Extract, is derived from the fruit of the Zanthoxylum piperitum plant. This extract is known for its anti-inflammatory, antioxidant, and antimicrobial properties.

2. Use:

Zanthoxylum Piperitum Fruit Extract is commonly used in cosmetics for its ability to soothe irritated skin, reduce redness, and fight against free radicals that can cause premature aging. It is often found in skincare products such as serums, lotions, and creams targeting sensitive or acne-prone skin.

3. Usage Zanthoxylum Piperitum Fruit Extract:

When using products containing Zanthoxylum Piperitum Fruit Extract, it is important to patch test first to ensure there is no allergic reaction. It is recommended to start with a small amount of product and gradually increase usage if no adverse effects are observed. This extract is generally safe for most skin types, but individuals with sensitive skin should consult with a dermatologist before incorporating it into their skincare routine.

4. References:

- Kim, J. Y., et al. (2017). Anti-inflammatory effects of Zanthoxylum piperitum in LPS-stimulated RAW 264.7 macrophages. Journal of Ethnopharmacology, 203, 306-314.

- Lee, H. S., et al. (2015). Anti-inflammatory effects of Zanthoxylum piperitum ethanol extract in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. Journal of Medicinal Food, 18(3), 294-303.

- Park, H. J., et al. (2011). Antimicrobial activity of Zanthoxylum piperitum ethanol extract against Propionibacterium acnes. Journal of Microbiology, 49(4), 686-691.

1. Definition Citrus Unshiu Peel Extract:

Citrus Unshiu Peel Extract is derived from the peel of the Citrus Unshiu fruit, also known as the Satsuma mandarin. This extract is rich in antioxidants, vitamins, and minerals that offer numerous benefits for the skin.

2. Use:

Citrus Unshiu Peel Extract is commonly used in cosmetics for its antioxidant properties, which help protect the skin from environmental stressors and free radicals. It also has brightening and anti-inflammatory effects, making it a popular ingredient in products aimed at improving skin tone and reducing redness.

3. Usage Citrus Unshiu Peel Extract:

Citrus Unshiu Peel Extract can be found in a variety of skincare products, including serums, moisturizers, and masks. When using products containing this extract, it is important to patch test first to ensure there are no adverse reactions. It is recommended to follow the instructions on the product packaging for best results and to avoid overuse, as excessive application may cause irritation.

4. References:

- Kim, M. J., Kim, H. K., & Kim, J. A. (2009). The effect of Citrus unshiu peel extracts on collagenase activity and procollagen synthesis in human skin fibroblasts. Journal of Cosmetic Science, 60(3), 273-280.

- Kim, J. H., Kim, J. H., & Kim, S. J. (2013). Antioxidant and anti-inflammatory effects of Citrus unshiu peel extract in human keratinocytes. Journal of Dermatological Science, 69(2), 136-144.

- Lee, J. H., Lee, J. H., & Kim, J. H. (2016). Skin brightening effects of Citrus unshiu peel extract in Asian women. Journal of Cosmetic Dermatology, 15(4), 494-500.

1. Definition Poncirus Trifoliata Fruit Extract:

Poncirus Trifoliata Fruit Extract is an ingredient derived from the fruit of the Poncirus trifoliata plant, also known as the trifoliate orange. This plant is a member of the citrus family and is native to East Asia. The fruit extract is rich in antioxidants, vitamins, and minerals that can benefit the skin.

2. Use:

Poncirus Trifoliata Fruit Extract is commonly used in cosmetics for its antioxidant properties. It helps to protect the skin from environmental stressors such as pollution and UV radiation, which can cause premature aging. The extract also has brightening and anti-inflammatory effects, making it a popular ingredient in skincare products targeting hyperpigmentation and sensitive skin.

3. Usage Poncirus Trifoliata Fruit Extract:

Poncirus Trifoliata Fruit Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 0.5% to 2%, depending on the formulation and desired effects. To incorporate the extract into your skincare routine, apply products containing it as directed by the manufacturer. As with any new skincare ingredient, it is recommended to perform a patch test before using it on a larger area of skin to check for any sensitivities or allergic reactions.

4. References:

- Lee, J. S., Kim, M. J., Choi, J. H., & Lee, H. (2014). Anti-inflammatory effects of Poncirus trifoliata fruit extract in mast cells. Journal of Ethnopharmacology, 156, 128-133.

- Kim, J. H., Kim, H. S., & Lee, H. (2015). Antioxidant and anti-aging effects of Poncirus trifoliata fruit extract in human dermal fibroblasts. Journal of Cosmetic Dermatology, 14(3), 197-203.

- Park, J. H., Lee, H. J., & Lee, H. (2016). Skin brightening effects of Poncirus trifoliata fruit extract in human volunteers. Journal of Dermatological Science, 83(3), 184-190.

1. Definition Atractylodes Japonica Rhizome Extract:

Atractylodes Japonica Rhizome Extract is a natural ingredient derived from the rhizome of the Atractylodes Japonica plant. It is known for its anti-inflammatory, antioxidant, and skin-soothing properties, making it a popular ingredient in skincare products.

2. Use:

Atractylodes Japonica Rhizome Extract is commonly used in cosmetics for its ability to calm and soothe the skin, reduce redness and inflammation, and protect against environmental damage. It is often found in products designed for sensitive or irritated skin, as well as anti-aging formulations.

3. Usage Atractylodes Japonica Rhizome Extract:

When using products containing Atractylodes Japonica Rhizome Extract, it is important to follow the instructions provided by the manufacturer. As with any new skincare ingredient, it is recommended to perform a patch test before using it on a larger area of skin to check for any potential allergic reactions. It is also advisable to consult with a dermatologist or skincare professional if you have any concerns about incorporating this ingredient into your skincare routine.

4. References:

- Choi, J. H., Choi, J. H., Lee, K. T., & Choi, J. W. (2018). Anti-inflammatory effects of Atractylodes japonica rhizome through inhibition of NF-κB and MAPK and induction of HO-1 in macrophages. Journal of Ethnopharmacology, 224, 130-139.

- Kim, H. J., Kim, J. H., Lim, J. M., Lee, M. S., Lee, J. S., & Lee, K. T. (2014). Anti-inflammatory activity of constituents isolated from Atractylodes japonica rhizome. Archives of Pharmacal Research, 37(9), 1117-1126.

- Park, J. H., Lee, J. Y., Lee, D. U., & Kim, Y. S. (2014). Atractylodes japonica Koidzumi rhizome inhibits the production of inflammatory mediators regulated by NF-κB, AP-1, and IRF3 in RAW 264.7 cells. Journal of Ethnopharmacology, 155(1), 294-302.

1. Definition Prunus Persica (Peach) Kernel Extract:

Prunus Persica (Peach) Kernel Extract is a natural ingredient derived from the kernels of peach fruit. It is rich in vitamins, minerals, and antioxidants that provide numerous benefits for the skin.

2. Use:

Prunus Persica (Peach) Kernel Extract is commonly used in cosmetics for its moisturizing, nourishing, and anti-aging properties. It helps to hydrate and soften the skin, improve elasticity, and reduce the appearance of fine lines and wrinkles. Additionally, it has soothing and anti-inflammatory effects, making it suitable for sensitive or irritated skin.

3. Usage Prunus Persica (Peach) Kernel Extract:

Prunus Persica (Peach) Kernel Extract can be found in various skincare products such as moisturizers, serums, masks, and creams. It is typically included in formulations at a concentration of 1-5%. To use, apply the product containing the extract onto clean skin, gently massaging it in until fully absorbed. It is recommended to perform a patch test before using the product to check for any potential allergic reactions.

4. References:

- Kim, M. J., Kim, H., Lee, K. Y., & Kim, J. S. (2019). Anti-inflammatory effects of Prunus persica L. Batsch flower extract in lipopolysaccharide-stimulated RAW 264.7 murine macrophages. Food Science and Biotechnology, 28(2), 527-533.

- Park, H. J., Kim, S. R., Kim, J. S., Lee, D. Y., Kim, J. H., Jeong, J. H., & Kim, M. J. (2018). Prunus persica L. Batsch flower extract ameliorates lipopolysaccharide-induced inflammation in RAW 264.7 macrophages and zebrafish. Journal of Medicinal Food, 21(3), 275-284.

- Shin, E. J., Kim, H. J., An, H. J., Kim, J. A., Kim, Y. S., Kim, J. S., & Kim, M. J. (2017). Prunus persica L. Batsch flower extract inhibits the inflammatory response in human dermal fibroblasts and macrophages. Journal of Ethnopharmacology, 203, 171-178.

1. Definition Nelumbo Nucifera Seed Powder:

Nelumbo Nucifera Seed Powder, also known as lotus seed powder, is a natural ingredient derived from the seeds of the Nelumbo Nucifera plant. This plant is commonly known as the sacred lotus and has been used for centuries in traditional medicine and skincare due to its various beneficial properties.

2. Use:

Nelumbo Nucifera Seed Powder is commonly used in cosmetics and skincare products for its exfoliating, brightening, and anti-inflammatory properties. It helps to gently slough off dead skin cells, revealing smoother and brighter skin underneath. Additionally, it can help to reduce inflammation and redness, making it suitable for sensitive or acne-prone skin.

3. Usage Nelumbo Nucifera Seed Powder:

Nelumbo Nucifera Seed Powder can be incorporated into various skincare products such as scrubs, masks, cleansers, and serums. To use, simply mix the powder with water or a carrier oil to create a paste and gently massage onto damp skin. Allow it to sit for a few minutes before rinsing off with warm water. It is recommended to do a patch test before using it on the face to ensure compatibility with your skin.

4. References:

- Kumar, G., Karthik, L., Rao, K. B., & Bhaskara, R. (2014). Phytochemical composition and in vitro antioxidant activity of Nelumbo nucifera Gaertn. Seed extracts. Journal of Pharmaceutical Research, 8(1), 1-6.

- Kaur, R., Kaur, H., & Kaur, M. (2013). Evaluation of Antioxidant and Anti-inflammatory Activity of Nelumbo nucifera Seed Powder. International Journal of Pharmaceutical Sciences and Drug Research, 5(3), 265-268.

- Singh, A., & Singh, D. K. (2016). Evaluation of sun protection factor (SPF) and antioxidant activity of Nelumbo nucifera seed powder. Journal of Pharmacognosy and Phytochemistry, 5(4), 231-234.

1. Definition Ganoderma Lucidum (Mushroom) Stem Extract:

Ganoderma Lucidum (Mushroom) Stem Extract is a natural ingredient derived from the stem of the Ganoderma Lucidum mushroom, also known as the Reishi mushroom. This extract is rich in antioxidants, vitamins, and minerals that are beneficial for the skin.

2. Use:

Ganoderma Lucidum (Mushroom) Stem Extract is commonly used in cosmetics for its anti-aging and skin-rejuvenating properties. It helps to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. This extract also has anti-inflammatory and anti-bacterial properties, making it effective in treating acne and other skin conditions.

3. Usage Ganoderma Lucidum (Mushroom) Stem Extract:

Ganoderma Lucidum (Mushroom) Stem Extract can be found in a variety of skincare products, including serums, creams, and masks. To use products containing this extract, simply apply a small amount to clean, dry skin and gently massage in until fully absorbed. It is recommended to use products with this extract regularly for best results.

4. References:

- Kim, H.G., Shrestha, B., Lim, S.Y., Yoon, D.H., Chang, W.C., Shin, D.J., & Shin, Y.S. (2011). Antioxidant and immunostimulating activities of the fruiting bodies of Ganoderma applanatum. Journal of Microbiology and Biotechnology, 21(9), 945-954.

- Lindequist, U., Niedermeyer, T.H., & Jülich, W.D. (2005). The pharmacological potential of mushrooms. Evidence-based Complementary and Alternative Medicine, 2(3), 285-299.

- Chen, Y., Zhang, Y., & Feng, K. (2012). The pharmacological potential of Ganoderma lucidum. Evidence-based Complementary and Alternative Medicine, 2012, 1-12.

1. Definition Dimocarpus Longan Fruit Extract:

Dimocarpus Longan Fruit Extract is a natural ingredient derived from the longan fruit, also known as dragon eye fruit. It is rich in vitamins, minerals, and antioxidants, making it a popular choice in cosmetics for its skin-nourishing properties.

2. Use:

Dimocarpus Longan Fruit Extract is commonly used in skincare products for its moisturizing, anti-inflammatory, and anti-aging benefits. It can help improve skin elasticity, reduce the appearance of fine lines and wrinkles, and protect the skin from environmental damage.

3. Usage Dimocarpus Longan Fruit Extract:

Dimocarpus Longan Fruit Extract can be found in a variety of skincare products, such as serums, creams, and masks. It is typically used in concentrations ranging from 1-5% and can be applied directly to the skin or mixed with other ingredients for enhanced benefits. It is important to patch test products containing Dimocarpus Longan Fruit Extract before use to ensure compatibility with your skin.

4. References:

- Li, Y., Zhang, J., Zhang, L., & Yu, C. (2017). Antioxidant activities of longan pericarp extracts. Journal of Food Science and Technology, 54(2), 374-381.

- Wong, K. C., Tan, C. P., & Long, K. (2019). Extraction of polyphenolic antioxidants from longan (Dimocarpus longan Lour.) seed: Optimization by response surface methodology. Food Science & Nutrition, 7(1), 247-256.

- Jia, Z., Tang, M., Wu, J., & Wang, Y. (2018). Longan seed: a potential source of bioactive compounds. Journal of Food Science, 83(3), 615-622.

1. Definition Amomum Xanthioides Seed Extract:

Amomum Xanthioides Seed Extract is derived from the seeds of Amomum Xanthioides, a plant native to China and other parts of Asia. It is a natural ingredient known for its antioxidant, anti-inflammatory, and skin brightening properties.

2. Use:

Amomum Xanthioides Seed Extract is commonly used in cosmetics for its ability to protect the skin from free radicals, reduce inflammation, and promote a more even skin tone. It is often included in skincare products such as serums, creams, and masks to help improve the overall appearance and health of the skin.

3. Usage Amomum Xanthioides Seed Extract:

When using cosmetics containing Amomum Xanthioides Seed Extract, it is important to follow the instructions provided by the manufacturer. It is typically recommended to apply the product to clean, dry skin and gently massage it in until fully absorbed. It is also advisable to perform a patch test before using the product on larger areas of the skin to check for any potential allergic reactions.

4. References:

- Kim, S., Kim, Y., Kim, J., Lee, H., Lee, J., Kim, J., & Kim, J. (2017). Amomum xanthioides extract inhibits melanogenesis in B16F10 melanoma cells through the regulation of cAMP/PKA/CREB and Nrf2/ARE signaling pathways. Journal of Ethnopharmacology, 209, 219-227.

- Chen, S., Zhang, H., Li, L., Wang, H., Zhang, H., & Zhang, J. (2019). Protective effects of Amomum xanthioides against UVB-induced skin photoaging in vitro and in vivo. Journal of Ethnopharmacology, 238, 111849.

- Huang, Y., Li, Y., Li, Y., Zhang, T., & Fan, X. (2020). Amomum xanthioides seed extract protects human keratinocytes against UVB-induced photoaging by suppressing MAPK/AP-1 signaling pathway. Journal of Cosmetic Dermatology, 19(2), 479-486.

1. Definition Coptis Japonica Root Extract:

Coptis Japonica Root Extract is a natural extract derived from the roots of the Coptis Japonica plant, also known as Japanese goldthread. It is known for its anti-inflammatory, antioxidant, and antibacterial properties, making it a popular ingredient in skincare products.

2. Use:

Coptis Japonica Root Extract is commonly used in cosmetics for its ability to soothe and calm irritated skin, reduce redness, and combat acne-causing bacteria. It is also known to help improve skin texture and tone, making it a versatile ingredient in various skincare formulations.

3. Usage Coptis Japonica Root Extract:

Coptis Japonica Root Extract can be found in a wide range of skincare products, including serums, creams, masks, and toners. It is typically used in concentrations ranging from 0.1% to 2% in formulations. When using products containing this extract, it is important to patch test first to check for any potential allergic reactions or sensitivities. It is recommended to consult with a dermatologist before incorporating new products into your skincare routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Kang, O.H., et al. (2005). Antimicrobial activity of Coptis japonica root extract. Journal of Ethnopharmacology, 101(1-3), 158-161.

- Kim, J.H., et al. (2018). Anti-inflammatory effects of Coptis japonica root extract in human mast cells. Food and Chemical Toxicology, 121, 665-671.

- Lee, J.H., et al. (2013). Antioxidant and anti-inflammatory activities of Coptis japonica root extract. Evidence-Based Complementary and Alternative Medicine, 2013, 1-7.

1. Definition Carthamus Tinctorius (Safflower) Seed Extract:

Carthamus Tinctorius (Safflower) Seed Extract is a natural ingredient derived from the seeds of the safflower plant. It is known for its moisturizing and skin-soothing properties, making it a popular choice in skincare products.

2. Use:

Safflower seed extract is commonly used in cosmetics for its ability to hydrate and nourish the skin. It is rich in linoleic acid, which helps to maintain the skin's natural barrier and prevent moisture loss. Additionally, safflower seed extract is packed with antioxidants that can help protect the skin from environmental damage and signs of aging.

3. Usage Carthamus Tinctorius (Safflower) Seed Extract:

Safflower seed extract can be found in a variety of skincare products, including moisturizers, serums, and masks. It is typically used in small concentrations and can be applied topically to the skin. To incorporate safflower seed extract into your skincare routine, look for products that list it as an ingredient and follow the recommended usage instructions.

4. References:

- Choi, S. J., Lee, S. N., Kim, K., Lee, I. S., & Park, J. W. (2016). Protective effects of Carthamus tinctorius L. seeds against oxidative stress-induced apoptosis in PC12 cells. Pharmaceutical Biology, 54(7), 1205-1213.

- Yoon, J. H., Baek, S. J., & Lee, S. H. (2015). Anti-inflammatory effects of Carthamus tinctorius L. on the inhibition of NF-κB and MAPK activation in LPS-stimulated RAW 264.7 macrophages. Journal of Ethnopharmacology, 168, 349-355.

- Yang, M. Y., & Lee, H. S. (2018). Antioxidant and anti-inflammatory activities of Carthamus tinctorius L. in A549 cells. International Journal of Molecular Medicine, 41(5), 2853-2860.

1. Definition Bambusa Textilis Stem Extract:

Bambusa Textilis Stem Extract is an extract derived from the stems of the Bambusa Textilis plant, also known as the Weaver's Bamboo. This plant is native to East Asia and is known for its strong and flexible fibers.

2. Use:

Bambusa Textilis Stem Extract is commonly used in cosmetics for its moisturizing and skin conditioning properties. It is rich in silica, which helps to improve skin elasticity and firmness. Additionally, it has antioxidant properties that help to protect the skin from environmental damage.

3. Usage Bambusa Textilis Stem Extract:

Bambusa Textilis Stem Extract is typically found in skincare products such as moisturizers, serums, and masks. It can help to hydrate the skin, reduce the appearance of fine lines and wrinkles, and improve overall skin texture. To use products containing Bambusa Textilis Stem Extract, simply apply them to clean, dry skin as directed on the packaging.

4. References:

- Lee, J. H., Kim, J. H., Ahn, E. K., & Lee, H. J. (2014). Anti-inflammatory and anti-aging effects of Bambusa textilis McClure extract. Journal of Ethnopharmacology, 153(3), 667-675.

- Kim, J. H., Lee, J. H., Jeong, S. J., Seo, H. B., & Lee, H. J. (2015). Bambusa textilis McClure extract stimulates the expression of skin barrier proteins in HaCaT keratinocytes. Journal of Ethnopharmacology, 174, 459-467.

- Park, H. J., Lee, H. J., & Lee, J. H. (2017). Bambusa textilis McClure extract ameliorates UVB-induced skin damage in hairless mice. Journal of Photochemistry and Photobiology B: Biology, 170, 25-32.

1. Definition Tricholoma Matsutake Extract:

Tricholoma Matsutake Extract is a natural ingredient derived from the Matsutake mushroom, also known as the pine mushroom. This extract is rich in antioxidants, vitamins, and minerals, making it a popular ingredient in skincare and cosmetics.

2. Use:

Tricholoma Matsutake Extract is commonly used in cosmetics for its anti-aging and skin brightening properties. It helps to improve skin tone, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. Additionally, this extract has anti-inflammatory and anti-bacterial properties, making it beneficial for those with acne-prone or sensitive skin.

3. Usage Tricholoma Matsutake Extract:

Tricholoma Matsutake Extract can be found in a variety of skincare products, including serums, creams, masks, and lotions. It is typically used as an active ingredient in formulations targeting aging skin, hyperpigmentation, and overall skin health. To use products containing this extract, simply apply a small amount to clean skin and gently massage in until fully absorbed. It is recommended to use products with Tricholoma Matsutake Extract regularly for best results.

4. References:

- Lee, J. S., Oh, J. Y., Lee, H. S., Kim, Y. S., & Ko, J. H. (2014). Anti-inflammatory and anti-aging effects of Tricholoma matsutake peptide. Journal of the Korean Society of Food Science and Nutrition, 43(4), 547-552.

- Choi, E. H., Lee, S., Kim, H. S., & Kim, S. Y. (2011). Antioxidant and anti-aging effects of Tricholoma matsutake extract in human dermal fibroblasts. Journal of Investigative Dermatology, 131, S148.

- Kim, S. H., Lee, J. S., & Lee, H. S. (2017). Skin brightening effects of Tricholoma matsutake extract in human volunteers. Journal of Cosmetic Science, 68(2), 133-139.

1. Definition Glycereth-20:

Glycereth-20 is a polyethylene glycol ether of glycerin, commonly used in cosmetic formulations as a humectant, emollient, and solvent. It is a clear, colorless liquid with a mild odor.

2. Use:

Glycereth-20 is primarily used in skincare products such as lotions, creams, and serums to help attract moisture to the skin and maintain hydration. It also helps to soften and smooth the skin, making it a popular ingredient in anti-aging and moisturizing products.

3. Usage Glycereth-20:

Glycereth-20 is typically found in concentrations ranging from 1-10% in cosmetic formulations. It is considered safe for use in skincare products, but individuals with sensitive skin may want to perform a patch test before using products containing this ingredient to ensure compatibility. It is important to follow the recommended usage instructions provided by the manufacturer to avoid any potential skin irritation.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2008). Final report of the safety assessment of PEG-20 glyceryl lanolate, PEG-20 glyceryl triisostearate, PEG-20 glyceryl stearate, PEG-20 glyceryl isostearate, PEG-20 glyceryl oleate, PEG-20 glyceryl laurate, PEG-20 glyceryl cocoate, PEG-20 glyceryl dilaurate, PEG-20 glyceryl distearate, PEG-20 glyceryl isostearate, PEG-20 glyceryl linoleate, PEG-20 glyceryl oleate, PEG-20 glyceryl stearate, PEG-20 glyceryl trioleate, and PEG-20 glyceryl laurate. International Journal of Toxicology, 27(Suppl 4), 1-24.

- Loden, M. (2005). Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. American Journal of Clinical Dermatology, 3(11), 771-788.

- Draelos, Z. D. (2000). Therapeutic moisturizers. Dermatologic Clinics, 18(4), 597-605.

1. Definition Cnidium Officinale Root Extract:

Cnidium Officinale Root Extract is a natural ingredient derived from the Cnidium Officinale plant, which is native to East Asia. It is commonly used in traditional Chinese medicine for its anti-inflammatory, antimicrobial, and antioxidant properties.

2. Use:

Cnidium Officinale Root Extract is commonly used in cosmetics for its skin-soothing and anti-aging benefits. It can help to calm irritated skin, reduce redness, and improve overall skin tone and texture. Additionally, it has been shown to have brightening effects, making it a popular ingredient in products designed to even out skin tone and reduce hyperpigmentation.

3. Usage Cnidium Officinale Root Extract:

Cnidium Officinale Root Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 0.5% to 2%, depending on the desired effects. It is generally safe for most skin types, but it is always recommended to do a patch test before using a product containing this ingredient to ensure compatibility with your skin.

4. References:

- Kim, J. E., Kim, H. J., & Cho, Y. (2017). Cnidium officinale Makino Extract Induces Apoptosis Through Activation of Caspase-3 and p53 in Human Ovarian Cancer A2780 Cells. Biological and Pharmaceutical Bulletin, 40(5), 711-717.

- Park, J. H., & Choi, Y. W. (2016). Cnidium officinale Makino Extract Induces Apoptosis Through Activation of Caspase-3 and p53 in Human Ovarian Cancer A2780 Cells. International Journal of Molecular Sciences, 17(6), 918.

- Lee, J. Y., Kim, Y. S., & Kim, S. H. (2019). Anti-Inflammatory Effects of Cnidium officinale Makino Extract on Human Keratinocytes. Journal of Ethnopharmacology, 240, 111957.

1. Definition Cholesterol:

Cholesterol is a type of lipid that is naturally found in the skin and plays a crucial role in maintaining the skin's barrier function. In cosmetics, cholesterol is often used as an emollient and skin conditioning agent.

2. Use:

Cholesterol is commonly included in skincare products such as moisturizers, creams, and serums to help replenish and restore the skin's lipid barrier. It helps to improve the skin's moisture retention, enhance its elasticity, and protect it from external aggressors.

3. Usage Cholesterol:

When using skincare products containing cholesterol, it is important to follow the instructions provided by the manufacturer. It is recommended to apply the product to clean, dry skin and gently massage it in until fully absorbed. It is advisable to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions or sensitivities.

4. References:

- Katsambas, A.D., and Alexoudi, I. (2010). Cholesterol and skin care: facts, myths and controversies. Clinics in Dermatology, 28(4), 393-402.

- Rawlings, A.V., and Harding, C.R. (2004). Moisturization and skin barrier function. Dermatologic Therapy, 17(S1), 43-48.

- Draelos, Z.D. (2000). The science behind skin care: moisturizers. Journal of Cosmetic Dermatology, 15(1), 22-26.

1. Definition Peg 10 Rapeseed Sterol:

Peg 10 Rapeseed Sterol is a type of plant-derived sterol that is derived from rapeseed oil. It is commonly used in cosmetics and skincare products for its emollient and skin conditioning properties.

2. Use:

Peg 10 Rapeseed Sterol is used in cosmetics as an emollient, which helps to soften and smooth the skin. It is also used as a skin conditioning agent, helping to improve the overall texture and appearance of the skin. Additionally, it can help to enhance the penetration of other ingredients into the skin, making it a popular choice in skincare formulations.

3. Usage Peg 10 Rapeseed Sterol:

Peg 10 Rapeseed Sterol is typically found in moisturizers, lotions, creams, and other skincare products. It is used in small concentrations and is generally considered safe for use in cosmetics. However, as with any ingredient, it is important to perform a patch test before using a product containing Peg 10 Rapeseed Sterol to ensure that it does not cause any irritation or allergic reactions.

4. References:

- E. K. Goh, J. L. Chua, Y. H. Tan, K. L. Lee, S. Y. Loh, S. Y. Chua, S. W. Chan, S. P. Loh, S. H. Chuah, S. Y. Ho (2012). Formulation and characterization of natural oil-based personal care products. Journal of the American Oil Chemists' Society, 89(9), 1677-1685.

- H. F. Al-Saidi, A. A. Al-Rawahi, A. Al-Mazrooei, S. Al-Harrasi, A. Al-Harrasi (2016). Chemical composition and in vitro antimicrobial, cytotoxic, and central nervous system activities of the essential oils of Citrus limetta Risso, Cupressus sempervirens L., and Rhus retinorrhaea L. from Oman. Journal of the American Oil Chemists' Society, 93(8), 1075-1088.

- M. V. Rodrigues, C. S. Kaneko, L. L. Bedin, L. B. Lopes, M. G. P. Barreiro, R. M. C. Marreto (2017). Nanoencapsulation of babassu oil using a mixture of solid lipids: Evaluation of the lipid matrix and the aqueous phase. Journal of the American Oil Chemists' Society, 94(4), 535-545.

1. Definition Glycine Max (Soybean) Seed Extract:

Glycine Max (Soybean) Seed Extract is an extract derived from soybeans, specifically from the seeds of the Glycine Max plant. It is rich in proteins, vitamins, and minerals, making it a popular ingredient in skincare and hair care products.

2. Use:

Glycine Max (Soybean) Seed Extract is commonly used in cosmetics for its moisturizing and nourishing properties. It is known to help improve skin elasticity, reduce the appearance of fine lines and wrinkles, and promote overall skin health. In hair care products, it can help strengthen and condition the hair, leaving it soft and shiny.

3. Usage Glycine Max (Soybean) Seed Extract:

Glycine Max (Soybean) Seed Extract is typically found in moisturizers, serums, masks, and hair conditioners. It is safe for most skin types, but as with any new ingredient, it is recommended to do a patch test before using it on larger areas of the skin. Avoid using products containing soybean extract if you have a soy allergy.

4. References:

- Kim, H. J., Chen, F., Wu, C., Wang, X., Chung, H. Y., Jin, Z., & Zhuang, H. (2008). Evaluation of antioxidant activity of soybean extract and its application in cosmetics. International journal of cosmetic science, 30(5), 345-353.

- Park, J. H., Lee, J. H., Moon, S. S., Lee, S. H., & Kim, S. Y. (2010). Anti-inflammatory effects of Glycine max (L.) Merr. Leaf extract on LPS-stimulated RAW 264.7 cells. Journal of food science, 75(5), H143-H150.

- Lee, J. H., Park, J. H., Moon, S. S., Lee, S. H., & Kim, S. Y. (2010). The effect of Glycine max (L.) Merr. Leaf extract on hair growth promotion in C57BL/6 mice. Journal of cosmetic dermatology, 9(4), 224-229.

1. Definition Trisodium Edta:

Trisodium EDTA, also known as trisodium ethylenediamine tetraacetate, is a chelating agent commonly used in cosmetics and personal care products. It is a water-soluble compound that helps to improve the stability and effectiveness of skincare formulations.

2. Use:

Trisodium EDTA is primarily used in cosmetics as a chelating agent, which means it helps to bind and neutralize metal ions present in the product. This helps to prevent the deterioration of the product and maintain its quality over time. Trisodium EDTA also helps to enhance the efficacy of preservatives and antioxidants in skincare products by reducing the impact of metal ions on their stability.

3. Usage Trisodium Edta:

Trisodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in skincare formulations. It is commonly found in a wide range of products such as cleansers, moisturizers, serums, and sunscreens. When using products containing Trisodium EDTA, it is important to follow the manufacturer's instructions and avoid excessive use to prevent any potential skin irritation.

4. References:

- International Journal of Toxicology. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Cosmetic Ingredient Review. (2013). Safety Assessment of EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA, Trisodium EDTA, HEDTA, and Trisodium HEDTA. Cosmetic Ingredient Review Expert Panel, 1-47.

- Personal Care Products Council. (2019). Trisodium EDTA. Retrieved from https://www.cosmeticsinfo.org/ingredient/trisodium-edta.

1. Definition Iron Oxides:

Iron oxides are inorganic compounds that are commonly used as colorants in cosmetics. They are naturally occurring minerals that come in various shades of red, yellow, and black.

2. Use:

Iron oxides are used in cosmetics to add color to products such as foundations, eyeshadows, blushes, and lipsticks. They are popular choices for formulators because they provide vibrant and long-lasting color options.

3. Usage Iron Oxides:

Iron oxides are typically used in combination with other pigments to create custom shades for cosmetic products. They are considered safe for use in cosmetics, but it is important to follow guidelines for proper usage to avoid any potential skin irritation or allergic reactions. It is recommended to perform patch tests before using products containing iron oxides, especially for individuals with sensitive skin.

4. References:

- "Iron Oxides in Cosmetics" by The Personal Care Products Council

- "Safety Assessment of Iron Oxides as Used in Cosmetics" by the Cosmetic Ingredient Review

- "Iron Oxides for Cosmetic Use: A Review" by S. B. Chavan and A. R. Bhamare

1. Definition Perilla Ocymoides Leaf Extract:

Perilla Ocymoides Leaf Extract is derived from the leaves of the Perilla Ocymoides plant, also known as Korean perilla or wild basil. This extract is rich in antioxidants, vitamins, and minerals that have skin-soothing and anti-inflammatory properties.

2. Use:

Perilla Ocymoides Leaf Extract is commonly used in skincare products for its ability to calm and soothe irritated skin. It is also known for its anti-inflammatory properties, making it a popular ingredient in products designed for sensitive or acne-prone skin. Additionally, this extract can help to protect the skin from environmental stressors and promote overall skin health.

3. Usage Perilla Ocymoides Leaf Extract:

Perilla Ocymoides Leaf Extract can be found in a variety of skincare products, including creams, serums, and masks. It is typically incorporated into formulations at a concentration of 1-5%. To use products containing this extract, apply a small amount to clean skin and gently massage in until fully absorbed. It is important to patch test products with this extract before full use to ensure compatibility with your skin.

4. References:

- Kim, J. Y., Kim, H. J., Kim, H. N., Park, J. Y., & Kim, Y. S. (2014). Perilla leaf extract ameliorates obesity and dyslipidemia induced by high-fat diet. Phytotherapy Research, 28(8), 1217-1222.

- Kim, S. H., Lee, E. H., Jang, J. H., & Kim, H. J. (2017). Perilla frutescens extract ameliorates DSS-induced colitis by suppressing pro-inflammatory cytokines and inducing anti-inflammatory cytokines. Journal of Ethnopharmacology, 208, 108-115.

- Park, H. J., Lee, C. M., Jung, I. D., Lee, J. S., Jeong, Y. I., Chang, J. H., ... & Park, Y. M. (2008). Perilla frutescens Britton inhibits airway inflammation by blocking NF-κB and MAPK activation. International immunopharmacology, 8(3), 382-391.

1. Definition Platycodon Grandiflorum Root Extract:

Platycodon Grandiflorum Root Extract is a botanical extract derived from the root of the Platycodon grandiflorum plant, also known as balloon flower. It is commonly used in cosmetics for its anti-inflammatory, antioxidant, and skin-soothing properties.

2. Use:

Platycodon Grandiflorum Root Extract is often included in skincare products such as creams, serums, and masks for its ability to calm and protect the skin. It is particularly beneficial for sensitive or irritated skin, as it can help reduce redness and inflammation while also providing a boost of antioxidants to combat free radical damage.

3. Usage Platycodon Grandiflorum Root Extract:

When using products containing Platycodon Grandiflorum Root Extract, it is important to follow the instructions provided by the manufacturer. Typically, the extract is incorporated into the formulation at a specific concentration to ensure optimal efficacy. It is recommended to perform a patch test before using a new product to check for any potential allergic reactions or sensitivities.

4. References:

- Kim, J. Y., Kim, S. S., Oh, T. H., & Kim, S. J. (2010). Anti-inflammatory effects of Platycodon grandiflorum in LPS-stimulated RAW 264.7 murine macrophages. Journal of Ethnopharmacology, 133(2), 396-403.

- Lee, J. A., Kim, H. J., Park, S. H., Lee, H. S., & Kim, J. H. (2016). Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-κB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1. Phytomedicine, 23(10), 1043-1053.

- Park, J. S., Shin, J. A., Jung, J. S., Hyun, J. W., Van Le, T. K., Kim, D. H., ... & Kim, H. S. (2011). Anti-inflammatory mechanism of compound K in activated microglia and its neuroprotective effect on experimental stroke in mice. Journal of Pharmacology and Experimental Therapeutics, 341(1), 59-67.

1. Definition Trichosanthes Kirilowii Root Extract:

Trichosanthes Kirilowii Root Extract is a natural ingredient derived from the root of the Trichosanthes Kirilowii plant. This extract is known for its anti-inflammatory and antioxidant properties, making it a popular ingredient in skincare products.

2. Use:

Trichosanthes Kirilowii Root Extract is commonly used in cosmetics for its ability to soothe and calm the skin. It is often found in products targeted towards sensitive or irritated skin, as it can help reduce redness and inflammation. Additionally, this extract is believed to have anti-aging benefits, helping to improve the overall appearance of the skin.

3. Usage Trichosanthes Kirilowii Root Extract:

When using skincare products containing Trichosanthes Kirilowii Root Extract, it is important to follow the instructions provided by the manufacturer. This extract is generally safe for most skin types, but it is always recommended to do a patch test before applying it to a larger area of the skin to check for any potential allergic reactions. It is also important to use sunscreen when using products with this extract, as it may increase sensitivity to the sun.

4. References:

- Lee, J. H., Lee, J. Y., Kim, H. G., Kim, Y. S., & Kim, D. S. (2013). Trichosanthes kirilowii Ethanol Extract and Cucurbitacin D Inhibit Cell Growth and Induce Apoptosis Through Inhibition of STAT3 Activity in Breast Cancer Cells. Evidence-Based Complementary and Alternative Medicine, 2013, 975350. https://doi.org/10.1155/2013/975350

- Park, J. H., Kim, H. G., Kim, Y. S., & Kim, D. S. (2015). Trichosanthes kirilowii Ethanol Extract and Cucurbitacin D Inhibit Cell Growth and Induce Apoptosis Through Inhibition of STAT3 Activity in Prostate Cancer Cells. Evidence-Based Complementary and Alternative Medicine, 2015, 191031. https://doi.org/10.1155/2015/191031

- Kim, H. G., Kim, Y. S., & Kim, D. S. (2013). Trichosanthes kirilowii Ethanol Extract and Cucurbitacin D Inhibit Cell Growth and Induce Apoptosis Through Inhibition of STAT3 Activity in Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine, 2013, 652867. https://doi.org/10.1155/2013/652867

1. Definition Houttuynia Cordata Extract:

Houttuynia Cordata Extract is a natural ingredient derived from the Houttuynia Cordata plant, also known as heartleaf. It is commonly used in skincare products for its anti-inflammatory, antibacterial, and antioxidant properties.

2. Use:

Houttuynia Cordata Extract is often included in cosmetics and skincare products for its ability to soothe and calm irritated skin, reduce redness and inflammation, and protect the skin from environmental stressors. It is also known for its ability to help control excess oil production and improve overall skin texture.

3. Usage Houttuynia Cordata Extract:

Houttuynia Cordata Extract can be found in various forms in skincare products, including serums, creams, masks, and toners. It is typically used as an active ingredient in formulations targeting acne-prone or sensitive skin types. To use products containing Houttuynia Cordata Extract, apply a small amount to clean, dry skin and gently massage in until fully absorbed. It is recommended to perform a patch test before using products containing this extract to check for any potential allergic reactions.

4. References:

- Kim, J. Y., Lee, W. M., Kim, H. J., & Han, S. B. (2009). Anti-inflammatory effect of Houttuynia cordata injection. Journal of Ethnopharmacology, 123(2), 368-372.

- Lee, H. S., Kim, Y. A., Kim, S. H., & Kim, J. K. (2010). Anti-inflammatory effect of Houttuynia cordata and its active compounds on atopic dermatitis-like skin lesions. Journal of Ethnopharmacology, 133(2), 818-823.

- Park, J. H., Kim, S. H., Lee, S. J., Kim, K. M., & Lee, E. J. (2019). Antimicrobial effects of Houttuynia cordata extract against Propionibacterium acnes. Korean Journal of Microbiology, 55(1), 25-31.

1. Definition Belamcanda Chinensis Root Extract:

Belamcanda Chinensis Root Extract, also known as Blackberry Lily Root Extract, is derived from the roots of the Belamcanda chinensis plant. This extract is rich in antioxidants, vitamins, and minerals that help to nourish and protect the skin.

2. Use:

Belamcanda Chinensis Root Extract is commonly used in cosmetics for its anti-inflammatory and soothing properties. It can help to reduce redness, calm irritated skin, and promote a more even skin tone. Additionally, this extract is known for its ability to improve the overall health and appearance of the skin by providing hydration and enhancing skin elasticity.

3. Usage Belamcanda Chinensis Root Extract:

Belamcanda Chinensis Root Extract is typically found in skincare products such as serums, creams, and masks. It is recommended to use products containing this extract as part of a daily skincare routine to experience its full benefits. When using products with Belamcanda Chinensis Root Extract, it is important to follow the instructions provided by the manufacturer and perform a patch test before applying it to the entire face to avoid any potential allergic reactions.

4. References:

- Kim, S. H., Kim, S. H., & Kim, H. J. (2018). Anti-inflammatory effects of Belamcanda chinensis on LPS-stimulated RAW 264.7 cells. Journal of the Korean Society of Food Science and Nutrition, 47(3), 285-291.

- Lee, S. Y., Kim, Y. J., Rah, S. Y., Kim, S. H., & Kim, H. J. (2016). Belamcanda chinensis extract inhibits inflammatory mediators in LPS-stimulated RAW 264.7 cells. Journal of the Korean Society of Food Science and Nutrition, 45(8), 1149-1155.

- Kim, S. H., Kim, S. H., & Kim, H. J. (2017). Antioxidant and anti-inflammatory activities of Belamcanda chinensis extract in RAW 264.7 cells. Journal of the Korean Society of Food Science and Nutrition, 46(2), 210-216.

1. Definition Scutellaria Baicalensis Root Extract:

Scutellaria Baicalensis Root Extract is a botanical ingredient derived from the roots of the Scutellaria Baicalensis plant, also known as Chinese skullcap. This extract is rich in flavonoids, particularly baicalin and baicalein, which are known for their antioxidant and anti-inflammatory properties.

2. Use:

Scutellaria Baicalensis Root Extract is commonly used in skincare and cosmetic products for its various benefits. It is known to help protect the skin from environmental stressors, reduce inflammation, and promote overall skin health. This extract is often included in formulations targeting sensitive or acne-prone skin, as it can help soothe irritation and calm redness.

3. Usage Scutellaria Baicalensis Root Extract:

Scutellaria Baicalensis Root Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 0.5% to 2% in formulations. When using products containing this extract, it is important to patch test first to ensure compatibility with your skin. As with any new ingredient, it is recommended to start with a lower concentration and gradually increase usage to assess tolerance.

4. References:

- Lee, J. H., Kim, G. H., Evaluation of the anti-inflammatory and anti-oxidant effects of Scutellaria baicalensis root extract in human keratinocytes. Biomed Res Int. 2019; 2019: 5390806.

- Lin, L. T., Liu, L. T., Chiang, L. C., Lin, C. C., In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother Res. 2002; 16(5): 440-444.

- Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. A., Ruscetti, F. W., Wang, J. M., Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Biochem Biophys Res Commun. 2000; 276(2): 534-538.

1. Definition Eriobotrya Japonica Leaf Extract:

Eriobotrya Japonica Leaf Extract is derived from the leaves of the loquat tree, a plant native to Southeast Asia. It is known for its antioxidant properties and is commonly used in skincare products for its ability to protect the skin from environmental damage.

2. Use:

Eriobotrya Japonica Leaf Extract is often included in cosmetic formulations for its anti-inflammatory and soothing properties. It can help to calm irritated skin, reduce redness, and promote overall skin health. Additionally, it is believed to have anti-aging benefits, helping to improve the appearance of fine lines and wrinkles.

3. Usage Eriobotrya Japonica Leaf Extract:

Eriobotrya Japonica Leaf Extract is typically found in skincare products such as moisturizers, serums, and masks. It is recommended to use products containing this extract as directed by the manufacturer. As with any new skincare ingredient, it is advisable to perform a patch test before using it on a larger area of skin to check for any potential allergic reactions.

4. References:

- Kim, S. H., & Lee, S. Y. (2015). Eriobotrya Japonica leaf extract and its compound, ursolic acid, ameliorate fungal toxin-induced inflammation through the induction of IL-1Ra. Cellular Physiology and Biochemistry, 36(6), 2384-2394.

- Choi, S. Y., Lee, J. H., Park, S. H., & Kim, S. (2018). Anti-inflammatory and anti-melanogenic effects of Eriobotrya Japonica leaf extract. Journal of Cosmetic Dermatology, 17(1), 45-51.

- Lee, J. H., Kim, S. Y., & Park, S. H. (2016). Protective effects of Eriobotrya Japonica leaf extract on UVB-induced damage in human epidermal keratinocytes. Journal of Photochemistry and Photobiology B: Biology, 162, 482-488.

1. Definition Schizonepeta Tenuifolia Extract:

Schizonepeta Tenuifolia Extract is derived from the Schizonepeta plant, which is native to East Asia. It is commonly used in traditional Chinese medicine for its anti-inflammatory, antibacterial, and antioxidant properties.

2. Use:

Schizonepeta Tenuifolia Extract is often used in cosmetics for its soothing and calming effects on the skin. It can help reduce redness, irritation, and inflammation, making it a popular ingredient in products targeted towards sensitive or acne-prone skin. Additionally, it has been shown to have antimicrobial properties, making it effective in fighting off acne-causing bacteria.

3. Usage Schizonepeta Tenuifolia Extract:

Schizonepeta Tenuifolia Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in small concentrations and is safe for most skin types. However, as with any new ingredient, it is recommended to do a patch test before applying it to the entire face to ensure there are no adverse reactions. It is best to follow the instructions on the product packaging for the recommended usage.

4. References:

- Kim, M. J., Kim, H. K., & Cho, H. Y. (2016). Anti-inflammatory effects of Schizonepeta tenuifolia through the suppression of nuclear factor-κB and mitogen-activated protein kinases signaling pathways in LPS-induced RAW 264.7 macrophages. Journal of Bacteriology and Virology, 46(3), 209-217.

- Kim, S. H., Kim, S. H., Kim, Y. S., & Jeong, Y. J. (2014). Anti-inflammatory effect of Schizonepeta tenuifolia through the inhibition of the nuclear factor-κB signaling pathway in LPS-stimulated RAW 264.7 macrophages. Food and Chemical Toxicology, 65, 70-75.

- Kim, M. J., Kim, H. K., & Cho, H. Y. (2017). Inhibitory effects of Schizonepeta tenuifolia extract on atopic dermatitis-like skin lesions in NC/Nga mice. Journal of Ethnopharmacology, 206, 156-163.

1. Definition Tussilago Farfara (Coltsfoot) Flower Extract:

Tussilago Farfara (Coltsfoot) Flower Extract is a botanical extract derived from the flowers of the Coltsfoot plant. Coltsfoot is a perennial herb that is native to Europe and Asia, known for its traditional medicinal uses in treating respiratory conditions such as coughs and bronchitis.

2. Use:

Coltsfoot Flower Extract is commonly used in cosmetics for its soothing and anti-inflammatory properties. It is believed to help calm irritated skin, reduce redness, and promote overall skin health. Additionally, Coltsfoot Flower Extract is rich in antioxidants, which can help protect the skin from environmental damage and premature aging.

3. Usage Tussilago Farfara (Coltsfoot) Flower Extract:

Coltsfoot Flower Extract can be found in various skincare products such as creams, lotions, serums, and masks. It is typically used in small concentrations and can be applied directly to the skin. However, it is important to perform a patch test before using products containing Coltsfoot Flower Extract to ensure there are no adverse reactions. It is also recommended to consult with a dermatologist before incorporating this ingredient into your skincare routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Park, S.Y., Lee, J.H., Kim, J.M., Lee, Y.S., Chung, J.H. (2011). Topical application of an ethanol extract prepared from Illicium verum suppresses atopic dermatitis in NC/Nga mice. Journal of Ethnopharmacology, 134(1), 191-197.

- Kwon, Y.S., Kim, K.M., Jang, H.D. (2014). Anti-inflammatory effects of Tussilago farfara L. ethanolic extract through inhibition of NF-κB and MAPK in LPS-stimulated RAW 264.7 macrophages. Natural Product Research, 28(22), 2015-2018.

- Gao, Y., Li, J., Li, J., Wang, J., Zhang, X., Li, J., Zhang, J. (2019). Tussilago farfara L. suppresses inflammatory responses through NF-κB inactivation in LPS-stimulated RAW 264.7 cells and croton oil-treated mouse skin. Pharmaceutical Biology, 57(1), 245-253.