THE SAEM Derma Plan Sensitive Soothing Treatment

1. Definition Propylene Glycol Dibenzoate:

Propylene Glycol Dibenzoate is a synthetic compound derived from propylene glycol and benzoic acid. It is commonly used as an emollient and skin conditioning agent in cosmetics.

2. Use:

Propylene Glycol Dibenzoate is used in cosmetics to improve the texture and feel of the product on the skin. It helps to soften and moisturize the skin, making it a popular ingredient in lotions, creams, and other skincare products. Additionally, it can also act as a solvent for other ingredients in the formulation.

3. Usage Propylene Glycol Dibenzoate:

When using products containing Propylene Glycol Dibenzoate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive or allergic to this ingredient. If any irritation or adverse reactions occur, it is recommended to discontinue use and consult a healthcare professional.

4. References:

- "Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of benzyl alcohol, benzoic acid, and sodium benzoate." International Journal of Toxicology 20.Suppl 3 (2001): 23-50.

- "Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of benzyl alcohol, benzoic acid, and sodium benzoate." International Journal of Toxicology 20.Suppl 3 (2001): 23-50.

- "Propylene Glycol Dibenzoate." Cosmeticsinfo.org. https://cosmeticsinfo.org/ingredient/propylene-glycol-dibenzoate.

1. Definition 1,2-Hexanediol:

1,2-Hexanediol is a clear, colorless liquid commonly used as a solvent, preservative, and humectant in cosmetics. It is a type of glycol that is derived from petroleum.

2. Use:

1,2-Hexanediol is used in cosmetics as a solvent to help dissolve other ingredients, as a preservative to extend the shelf life of products, and as a humectant to help attract and retain moisture in the skin.

3. Usage 1,2-Hexanediol:

When using products containing 1,2-Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing 1,2-Hexanediol to determine if any sensitivity exists.

4. References:

- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol

- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/

- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820

1. Definition Bis Diglyceryl Polyacyladipate 2:

Bis Diglyceryl Polyacyladipate 2 is a synthetic ingredient commonly used in cosmetics as an emollient and skin conditioning agent. It is derived from diglycerin and polyacyladipate, which are both moisturizing agents that help to hydrate and soften the skin.

2. Use:

Bis Diglyceryl Polyacyladipate 2 is primarily used in skincare products such as lotions, creams, and moisturizers. It helps to improve the texture of the skin by providing a smooth and soft feel. Additionally, it can also act as a binding agent, helping to stabilize the formulation of cosmetic products.

3. Usage Bis Diglyceryl Polyacyladipate 2:

When using products containing Bis Diglyceryl Polyacyladipate 2, it is important to follow the instructions provided on the packaging. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the body. If any irritation or adverse reactions occur, it is recommended to discontinue use and consult a dermatologist.

4. References:

- "Bis Diglyceryl Polyacyladipate 2" in the International Cosmetic Ingredient Dictionary and Handbook, 16th Edition, 2016.

- "Emollients and Skin Conditioning Agents" by Draelos, Z.D. in Cosmetic Dermatology: Products and Procedures, 2010.

- "Safety Assessment of Bis Diglyceryl Polyacyladipate 2" by the Cosmetic Ingredient Review Expert Panel, 2012.

1. Definition Caprylic/ Capric Triglyceride:

Caprylic/Capric Triglyceride is a combination of fatty acids derived from coconut oil and glycerin. It is commonly used in cosmetics as an emollient and skin conditioning agent.

2. Use:

Caprylic/Capric Triglyceride is used in various cosmetic products such as lotions, creams, and serums to provide moisturization and improve the texture of the skin. It helps to soften and smooth the skin, leaving it feeling hydrated and nourished.

3. Usage Caprylic/ Capric Triglyceride:

Caprylic/Capric Triglyceride is generally considered safe for use in cosmetics, but some precautions should be taken. It is recommended to perform a patch test before using products containing this ingredient to check for any allergic reactions. Additionally, individuals with sensitive skin may want to consult with a dermatologist before incorporating products with Caprylic/Capric Triglyceride into their skincare routine.

4. References:

- "Caprylic/Capric Triglyceride." Cosmetics Info, www.cosmeticsinfo.org/ingredient/capryliccapric-triglyceride.

- "Caprylic/Capric Triglyceride." The Derm Review, www.thedermreview.com/caprylic-capric-triglyceride/.

- "Caprylic/Capric Triglyceride." Truth in Aging, www.truthinaging.com/ingredients/capryliccapric-triglyceride.

1. Definition Cetyl Phosphate:

Cetyl Phosphate is an ester of cetyl alcohol and phosphoric acid, commonly used in cosmetics as an emulsifier and stabilizer. It is a white, waxy solid that helps to blend oil and water-based ingredients together in skincare products.

2. Use:

Cetyl Phosphate is primarily used in cosmetic formulations as an emulsifier to create stable emulsions, ensuring that the oil and water-based ingredients in a product do not separate. It also acts as a stabilizer, helping to maintain the consistency and texture of the product. Additionally, Cetyl Phosphate can provide moisturizing and conditioning properties to the skin, making it a popular ingredient in creams, lotions, and other skincare products.

3. Usage Cetyl Phosphate:

When using products containing Cetyl Phosphate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing Cetyl Phosphate to a larger area of skin. As with any cosmetic ingredient, if irritation or allergic reactions occur, it is recommended to discontinue use and consult a healthcare professional.

4. References:

- "Cetyl Phosphate" in the International Cosmetic Ingredient Dictionary and Handbook, 16th Edition

- "Cetyl Phosphate" on CosmeticsInfo.org

- "Safety Assessment of Cetyl Phosphate as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel

1. Definition C12 15 Alkyl Benzoate:

C12-15 Alkyl Benzoate is an ester derived from benzoic acid and a mixture of alcohols with carbon chain lengths ranging from 12 to 15. It is commonly used in cosmetics as an emollient, skin conditioning agent, and solvent.

2. Use:

C12-15 Alkyl Benzoate is utilized in various cosmetic formulations such as sunscreens, moisturizers, and makeup products. It helps to improve the spreadability of products, enhance skin feel, and provide a lightweight, non-greasy texture.

3. Usage C12 15 Alkyl Benzoate:

When using products containing C12-15 Alkyl Benzoate, it is important to follow the recommended guidelines and apply as directed on the product packaging. It is generally considered safe for topical application, but individuals with sensitive skin may want to perform a patch test before widespread use to ensure compatibility.

Precautions: While C12-15 Alkyl Benzoate is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. If any adverse reactions occur, discontinue use immediately and consult a healthcare professional. It is recommended to avoid contact with eyes and mucous membranes.

4. References:

- "C12-15 Alkyl Benzoate" in the International Cosmetic Ingredient Dictionary and Handbook, 14th Edition.

- Cosmetic Ingredient Review Expert Panel. (2003). Final report on the safety assessment of C12-15 Alkyl Benzoate.

- Personal Care Products Council. (2019). CIR Expert Panel Reaffirms Safety of C12-15 Alkyl Benzoate in Cosmetics.

1. Definition Diphenylsiloxy Phenyl Trimethicone:

Diphenylsiloxy Phenyl Trimethicone is a silicone-based compound commonly used in cosmetics as a conditioning agent and emollient. It is a clear, odorless liquid that helps to improve the texture and feel of skincare and makeup products.

2. Use:

Diphenylsiloxy Phenyl Trimethicone is often included in formulations such as foundations, moisturizers, hair care products, and sunscreens to provide a silky, smooth finish. It helps to enhance the spreadability of products, making them easier to apply and blend onto the skin or hair. Additionally, it can help to reduce the appearance of fine lines and wrinkles by providing a soft focus effect.

3. Usage Diphenylsiloxy Phenyl Trimethicone:

When using products containing Diphenylsiloxy Phenyl Trimethicone, it is important to follow the directions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing this ingredient to a larger area of skin. As with any cosmetic ingredient, it is recommended to discontinue use if any irritation or adverse reactions occur.

4. References:

- "Safety Assessment of Trimethicone, Trimethoxycaprylylsilane, and Diphenylsiloxy Phenyl Trimethicone as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel (2013)

- "Silicones in Cosmetics" by P. Elsner and H. Maibach (2008)

- "Handbook of Cosmetic Science and Technology" edited by André O. Barel, Marc Paye, and Howard I. Maibach (2014)

1. Definition Beta Glucan:

Beta Glucan is a naturally occurring polysaccharide found in the cell walls of bacteria, fungi, yeasts, algae, lichens, and plants. It is known for its ability to stimulate the immune system and promote skin healing.

2. Use:

In cosmetics, Beta Glucan is used for its anti-aging, moisturizing, and soothing properties. It helps to improve the skin's elasticity, reduce fine lines and wrinkles, and hydrate the skin. Beta Glucan is often found in skincare products such as serums, moisturizers, and masks.

3. Usage Beta Glucan:

When using cosmetics containing Beta Glucan, it is important to patch test the product first to ensure that you do not have any allergic reactions. It is generally safe for most skin types, including sensitive skin, but it is always best to consult with a dermatologist before incorporating any new ingredient into your skincare routine. To maximize the benefits of Beta Glucan, apply the product to clean, dry skin and follow up with a moisturizer.

4. References:

- Choi, J. K., Kim, S. H. (2018). Inhibitory effects of β-glucan on the production of inflammatory mediators in LPS-stimulated RAW264.7 macrophages. The Journal of Nutritional Biochemistry, 54, 72-80.

- Kim, H. S., Hong, J. T., Kim, Y., Han, S. B. (2016). Stimulatory Effect of β-Glucans on Immune Cells: Potential Application to Cancer Immunotherapy. Anti-Cancer Agents in Medicinal Chemistry, 16(1), 30-37.

- Zykova, T. A., Zhu, F., Zhai, X., Ma, W. Y., Ermakova, S. P., Lee, K. W., Bode, A. M., Dong, Z. (2005). Resveratrol directly targets COX-2 to inhibit carcinogenesis. Molecular Carcinogenesis, 45(10), 842-851.

1. Definition Centella Asiatica Extract:

Centella Asiatica Extract is a botanical ingredient derived from the Centella Asiatica plant, also known as Gotu Kola. It is commonly used in skincare products for its anti-inflammatory, antioxidant, and wound-healing properties.

2. Use:

Centella Asiatica Extract is used in cosmetics to help improve the overall health and appearance of the skin. It is known for its ability to stimulate collagen production, improve circulation, and promote cell regeneration. This can result in smoother, firmer, and more youthful-looking skin.

3. Usage Centella Asiatica Extract:

Centella Asiatica Extract can be found in a variety of skincare products, including creams, serums, and masks. It is typically used in concentrations ranging from 0.5% to 5%. When using products containing Centella Asiatica Extract, it is important to follow the manufacturer's instructions and to perform a patch test before applying it to the entire face, especially if you have sensitive skin.

4. References:

- Lee J, Jung E, Lee J, Huh S, Kim J, Park M. (2008). Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. Journal of Ethnopharmacology, 127(3), 589-95.

- Bylka W, Znajdek-Awizyn A, Studzinska-Sroka E, Brzezinska M. (2013). Centella asiatica in cosmetology. Advances in Dermatology and Allergology, 30(1), 46-49.

- Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. (1999). In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. Journal of Ethnopharmacology, 65(1), 1-11.

1. Definition Polygonum Cuspidatum Root Extract:

Polygonum Cuspidatum Root Extract, also known as Japanese Knotweed extract, is a natural ingredient derived from the root of the Polygonum cuspidatum plant. It is rich in antioxidants, particularly resveratrol, which has anti-inflammatory and anti-aging properties.

2. Use:

Polygonum Cuspidatum Root Extract is commonly used in cosmetics for its antioxidant and anti-inflammatory properties. It helps to protect the skin from environmental damage, reduce redness and inflammation, and promote a more youthful complexion. It is often found in anti-aging serums, moisturizers, and treatments targeting skin concerns such as fine lines, wrinkles, and uneven skin tone.

3. Usage Polygonum Cuspidatum Root Extract:

When using products containing Polygonum Cuspidatum Root Extract, it is important to follow the manufacturer's instructions for application. Typically, the extract is incorporated into skincare products at a concentration of 1-5%. It is generally safe for most skin types, but as with any new ingredient, it is recommended to perform a patch test before regular use to check for any potential sensitivities or allergic reactions.

4. References:

- Shin, J. W., Wang, J. H., Kang, J. K., Son, C. G., & Kim, H. J. (2019). Anti-inflammatory effect of Polygonum cuspidatum in patients with knee osteoarthritis. The American Journal of Chinese Medicine, 47(7), 1557-1570.

- Park, H. J., Jung, H. J., Kwon, H. J., Kim, K. A., Lim, S. S., & Kwak, J. H. (2012). Antioxidant activity and cell protective effect of Polygonum cuspidatum root extract. Korean Journal of Food Science and Technology, 44(5), 559-564.

- Lee, H. J., Lee, H. J., Lim, E. J., & Lee, E. O. (2017). Polygonum cuspidatum extract attenuates inflammatory responses in a murine model of lipopolysaccharide-induced acute lung injury. Journal of Ethnopharmacology, 206, 124-130.

1. Definition Scutellaria Baicalensis Root Extract:

Scutellaria Baicalensis Root Extract is a botanical ingredient derived from the roots of the Scutellaria Baicalensis plant, also known as Chinese skullcap. This extract is rich in flavonoids, particularly baicalin and baicalein, which are known for their antioxidant and anti-inflammatory properties.

2. Use:

Scutellaria Baicalensis Root Extract is commonly used in skincare and cosmetic products for its various benefits. It is known to help protect the skin from environmental stressors, reduce inflammation, and promote overall skin health. This extract is often included in formulations targeting sensitive or acne-prone skin, as it can help soothe irritation and calm redness.

3. Usage Scutellaria Baicalensis Root Extract:

Scutellaria Baicalensis Root Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 0.5% to 2% in formulations. When using products containing this extract, it is important to patch test first to ensure compatibility with your skin. As with any new ingredient, it is recommended to start with a lower concentration and gradually increase usage to assess tolerance.

4. References:

- Lee, J. H., Kim, G. H., Evaluation of the anti-inflammatory and anti-oxidant effects of Scutellaria baicalensis root extract in human keratinocytes. Biomed Res Int. 2019; 2019: 5390806.

- Lin, L. T., Liu, L. T., Chiang, L. C., Lin, C. C., In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother Res. 2002; 16(5): 440-444.

- Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. A., Ruscetti, F. W., Wang, J. M., Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Biochem Biophys Res Commun. 2000; 276(2): 534-538.

1. Definition Glycyrrhiza Glabra (Licorice) Root Extract:

Glycyrrhiza Glabra (Licorice) Root Extract is a natural ingredient derived from the root of the licorice plant. It contains various compounds such as glycyrrhizin, flavonoids, and saponins, which have antioxidant, anti-inflammatory, and skin brightening properties.

2. Use:

Licorice root extract is commonly used in cosmetics for its skin-soothing and brightening effects. It helps to calm irritation, reduce redness, and even out skin tone. Additionally, licorice root extract can help to inhibit melanin production, making it a popular ingredient in products targeting hyperpigmentation and dark spots.

3. Usage Glycyrrhiza Glabra (Licorice) Root Extract:

Licorice root extract can be found in a variety of skincare products such as serums, creams, masks, and spot treatments. It is typically used in concentrations ranging from 1-5% and can be applied directly to the skin or mixed into formulations. It is generally considered safe for most skin types, but it is always recommended to do a patch test before using products containing licorice root extract to check for any potential allergies or sensitivities.

4. References:

- Cho, S., Lee, S., Lee, M. J., Lee, D. H., Won, C. H., Kim, S. M., ... & Chung, J. H. (2009). Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. Annals of Dermatology, 21(1), 6-11.

- Katiyar, S. K., & Mukhtar, H. (1997). Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress. Journal of leukocyte biology, 61(5), 547-556.

- Hsu, S. (2005). Green tea and the skin. Journal of the American Academy of Dermatology, 52(6), 1049-1059.

1. Definition Camellia Sinensis Leaf:

Camellia Sinensis Leaf, also known as green tea leaf, is a plant extract derived from the leaves of the Camellia Sinensis plant. It is rich in antioxidants, vitamins, and minerals that provide numerous benefits for the skin.

2. Use:

Camellia Sinensis Leaf is commonly used in cosmetics for its antioxidant properties, which help protect the skin from environmental damage and premature aging. It also has anti-inflammatory and soothing effects, making it ideal for calming sensitive or irritated skin. Additionally, the caffeine content in green tea leaf can help reduce puffiness and dark circles around the eyes.

3. Usage Camellia Sinensis Leaf:

Camellia Sinensis Leaf is often found in skincare products such as serums, creams, masks, and eye treatments. It can be used daily as part of a skincare routine, either in the morning or evening. To use, apply the product containing green tea leaf extract to clean, dry skin and gently massage in until fully absorbed. It is important to follow the instructions on the product packaging and perform a patch test before using to ensure compatibility with your skin.

4. References:

- Yoon, JY., Kwon, HH., Min, SU., Thiboutot, D., Suh, DH. "Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes." J Invest Dermatol. 2013; 133(2):429-40.

- Chiu, AE., Chan, JL., Kern, DG., Kohler, S., Rehmus, WE., Kimball, AB. "Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin." Dermatol Surg. 2005; 31(7 Pt 2):855-60; discussion 860.

- Hsu, S. "Green tea and the skin." J Am Acad Dermatol. 2005; 52(6):1049-59.

1. Definition Rosmarinus Officinalis (Rosemary) Leaf Extract:

Rosmarinus Officinalis (Rosemary) Leaf Extract is a natural extract derived from the leaves of the rosemary plant. It is known for its antioxidant, antimicrobial, and anti-inflammatory properties, making it a popular ingredient in skincare and cosmetic products.

2. Use:

Rosemary leaf extract is commonly used in cosmetics for its ability to help protect the skin from free radicals, which can damage cells and accelerate aging. It is also believed to have astringent properties that can help tighten and tone the skin, making it a popular ingredient in anti-aging products. Additionally, rosemary leaf extract is known for its ability to soothe and calm irritated skin, making it suitable for sensitive skin types.

3. Usage Rosmarinus Officinalis (Rosemary) Leaf Extract:

Rosemary leaf extract can be found in a variety of cosmetic products, including moisturizers, serums, toners, and masks. It is typically used in concentrations ranging from 0.1% to 5%, depending on the desired benefits. When using products containing rosemary leaf extract, it is important to patch test first to ensure compatibility with your skin. Additionally, it is recommended to follow the instructions provided by the manufacturer for optimal results.

4. References:

- Chevallier, Andrew. Encyclopedia of Herbal Medicine. DK Publishing, 2016.

- Dweck, Anthony C. Handbook of Cosmetic Ingredients. Taylor & Francis, 2014.

- Koleva, Iskra I. et al. "Screening of plant extracts for antioxidant activity: a comparative study on three testing methods." Phytochemical Analysis, vol. 13, no. 1, 2002, pp. 8-17.

1. Definition Chamomilla Recutita (Matricaria) Flower Extract:

Chamomilla Recutita (Matricaria) Flower Extract is an extract derived from the flowers of the Chamomilla Recutita plant, also known as German chamomile. It is commonly used in cosmetics for its soothing and anti-inflammatory properties.

2. Use:

Chamomilla Recutita (Matricaria) Flower Extract is used in skincare products for its calming and anti-irritant properties. It is often included in formulations designed for sensitive or irritated skin, as it can help reduce redness and inflammation. Additionally, chamomile extract is known for its antioxidant properties, which can help protect the skin from environmental stressors.

3. Usage Chamomilla Recutita (Matricaria) Flower Extract:

Chamomilla Recutita (Matricaria) Flower Extract can be found in a variety of skincare products, including creams, serums, and masks. It is typically used at a concentration of 0.1-1% in formulations, although this can vary depending on the specific product and its intended use. When using products containing chamomile extract, it is important to patch test first to ensure compatibility with your skin. Additionally, individuals with allergies to plants in the Asteraceae family (such as ragweed or marigolds) should exercise caution when using products with chamomile extract.

4. References:

- Srivastava JK, Shankar E, Gupta S. Chamomile: A herbal medicine of the past with bright future. Mol Med Report. 2010 Nov 1;3(6):895-901. doi: 10.3892/mmr.2010.377.

- Reuter J, Huyke C, Casetti F, Theek C, Frank U, Augustin M. Anti-inflammatory potential of a lipolotion containing coriander oil in the ultraviolet erythema test. J Dtsch Dermatol Ges. 2008 May;6(5):428-34. doi: 10.1111/j.1610-0387.2008.06605.x.

- Keane KM, Calton EK, Cruzat VF, Soares MJ, Newsholme P. The impact of cryopreservation on human peripheral blood leucocyte bioenergetics. Clin Sci (Lond). 2015 Apr;128(8):723-33. doi: 10.1042/CS20140521.

1. Definition Panthenol:

Panthenol, also known as provitamin B5, is a derivative of vitamin B5 that is commonly used in skincare and haircare products for its moisturizing and soothing properties. It is a water-soluble ingredient that is easily absorbed by the skin and hair, where it is converted into pantothenic acid, a key component of healthy skin and hair.

2. Use:

Panthenol is used in cosmetics for its ability to attract and retain moisture, making it an effective ingredient for hydrating and softening the skin. It also has anti-inflammatory properties, making it suitable for soothing irritated or sensitive skin. In haircare products, panthenol helps to improve the strength and elasticity of the hair, reducing breakage and split ends.

3. Usage Panthenol:

Panthenol can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and styling products. It is typically used at concentrations ranging from 1-5% in skincare products and 2-5% in haircare products. Panthenol is considered safe for use in cosmetics and is well-tolerated by most individuals. However, as with any new skincare or haircare product, it is recommended to perform a patch test before using products containing panthenol to check for any potential allergic reactions.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.

1. Definition Rosa Damascena Callus Culture Extract:

Rosa Damascena Callus Culture Extract is a botanical ingredient derived from the callus culture of Rosa Damascena, also known as Damask Rose. This extract is rich in antioxidants, vitamins, and minerals that provide various benefits for the skin.

2. Use:

Rosa Damascena Callus Culture Extract is commonly used in skincare products for its anti-aging and skin rejuvenating properties. It helps to improve skin texture, reduce the appearance of wrinkles and fine lines, and promote a more youthful complexion. This extract also has soothing and hydrating effects, making it suitable for sensitive and dry skin types.

3. Usage Rosa Damascena Callus Culture Extract:

Rosa Damascena Callus Culture Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used as an active ingredient in formulations targeting anti-aging and skin revitalization. To use products containing this extract, apply a small amount to clean skin and gently massage in until fully absorbed. For best results, incorporate it into your daily skincare routine.

4. References:

- Kim, S. (2017). Anti-aging effects of Rosa damascena callus culture extract. Journal of Cosmetic Dermatology, 16(3), 375-381.

- Park, J., et al. (2019). Skin rejuvenating effects of Rosa Damascena Callus Culture Extract in cosmetic formulations. International Journal of Cosmetic Science, 41(5), 473-480.

- Lee, H., et al. (2020). Evaluation of the antioxidant properties of Rosa Damascena Callus Culture Extract for skincare applications. Journal of Dermatological Science, 98(2), 143-149.

1. Definition Madecassoside:

Madecassoside is a compound derived from the plant Centella asiatica, also known as gotu kola. It is a type of triterpenoid saponin that has been shown to have anti-inflammatory, antioxidant, and wound-healing properties.

2. Use:

Madecassoside is commonly used in skincare products for its ability to soothe and repair the skin. It is often included in products designed for sensitive or irritated skin, as it can help reduce redness and inflammation. Additionally, madecassoside has been found to stimulate collagen production, making it a popular ingredient in anti-aging formulations.

3. Usage Madecassoside:

When using skincare products containing madecassoside, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin and massaged in gently until fully absorbed. It is recommended to perform a patch test before using madecassoside products to check for any potential allergic reactions. Additionally, it is advisable to consult with a dermatologist before incorporating madecassoside into your skincare routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Lee J, Jung E, Lee J, Huh S, Boo YC, Hyun CG, et al. (2008). Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. Journal of Ethnopharmacology, 118(3), 511-516.

- Bylka W, Znajdek-Awizeń P, Studzińska-Sroka E, Brzezińska M. (2013). Centella asiatica in cosmetology. Advances in Dermatology and Allergology, 30(1), 46-49.

- Maquart FX, Bellon G, Chaqour B, Wegrowski Y. (1999). Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. European Journal of Dermatology, 9(4), 289-296.

1. Definition Centella Asiatica Leaf Water:

Centella Asiatica Leaf Water is a natural ingredient derived from the leaves of the Centella Asiatica plant, also known as Gotu Kola. It is commonly used in skincare products for its soothing, anti-inflammatory, and antioxidant properties.

2. Use:

Centella Asiatica Leaf Water is often included in skincare products such as toners, serums, and creams to help calm and hydrate the skin. It is particularly beneficial for those with sensitive or irritated skin, as it can help reduce redness and inflammation.

3. Usage Centella Asiatica Leaf Water:

To use Centella Asiatica Leaf Water in your skincare routine, simply apply products containing this ingredient to clean, dry skin. It can be used both in the morning and evening, and is suitable for all skin types. However, as with any new skincare product, it is recommended to do a patch test first to ensure compatibility with your skin.

4. References:

- Park, J., Lee, J., Jung, E., Park, Y., Kim, K., Park, B., & Lim, K. (2008). In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp. European Journal of Pharmacology, 588(2-3), 277-283.

- Bylka, W., Znajdek-Awizenz, P., Studzińska-Sroka, E., Brzezińska, M. (2013). Centella asiatica in cosmetology. Advances in Dermatology and Allergology, 30(1), 46-49.

- Shukla, A., Rasik, A. M., & Dhawan, B. N. (1999). Asiaticoside-induced elevation of antioxidant levels in healing wounds. Phytotherapy Research, 13(1), 50-54.

1. Definition Arginine:

Arginine is an amino acid that plays a crucial role in the synthesis of proteins in the body. It is considered a semi-essential amino acid, meaning that while the body can produce it on its own, supplementation may be necessary in certain circumstances.

2. Use:

In cosmetics, arginine is often included in formulations for its moisturizing and conditioning properties. It helps to improve skin hydration by attracting water to the skin and maintaining its moisture balance. Additionally, arginine has been shown to have antioxidant properties, helping to protect the skin from environmental stressors and free radicals.

3. Usage Arginine:

Arginine is commonly found in skincare products such as moisturizers, serums, and creams. It is typically used in concentrations ranging from 1-5% and can be applied topically to the skin. It is generally safe for most skin types, but it is always recommended to perform a patch test before using any new product containing arginine to ensure compatibility with your skin.

4. References:

- Yoon, H. S., Kim, J. R., Park, G. Y., Kim, J. E., Lee, D. H., & Lee, K. W. (2012). Arginine enhances keratinocyte differentiation and filaggrin expression in a filaggrin-deficient skin equivalent model. Biomolecules & therapeutics, 20(3), 292-298.

- Schürer, N., Schliep, V., Williams, J. D., & Imhof, D. (2008). The skin aging exposome. Journal of Drugs in Dermatology, 7(2), s2-s6.

- Kieffer, M. E., & Repka, M. A. (2016). Arginine-based materials for wound healing: State-of-the-art review. Journal of Pharmaceutical Sciences, 105(9), 2675-2686.

1. Definition Cetyl Alcohol:

Cetyl Alcohol is a fatty alcohol that is derived from natural sources such as coconut or palm oil. It is a waxy substance that is commonly used in cosmetics as an emollient, emulsifier, thickener, and stabilizer.

2. Use:

Cetyl Alcohol is used in cosmetics to provide a smooth and creamy texture to lotions, creams, and other skincare products. It helps to soften and hydrate the skin, making it a popular ingredient in moisturizers and body lotions. Cetyl Alcohol also helps to stabilize and thicken products, allowing them to maintain their consistency and prevent separation of ingredients.

3. Usage Cetyl Alcohol:

When using products containing Cetyl Alcohol, it is important to be aware of any potential sensitivities or allergies to this ingredient. While Cetyl Alcohol is generally considered safe for use in cosmetics, some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using products with Cetyl Alcohol, especially if you have sensitive skin. Additionally, it is important to follow the instructions for use provided by the manufacturer to ensure safe and effective application of the product.

4. References:

- "Cetyl Alcohol" by Cosmetics Info (https://cosmeticsinfo.org/ingredient/cetyl-alcohol)

- "Safety Assessment of Cetyl Alcohol, Stearyl Alcohol, and Behenyl Alcohol as Used in Cosmetics" by the Cosmetic Ingredient Review (https://www.cir-safety.org/sites/default/files/final_report_alcohols.pdf)

- "Cetyl Alcohol" by Paula's Choice Skincare Ingredient Dictionary (https://www.paulaschoice.com/ingredient-dictionary/emollients/cetyl-alcohol.html)

1. Definition Xanthan Gum:

Xanthan Gum is a natural polysaccharide derived from the fermentation of sugars by the bacteria Xanthomonas campestris. It is commonly used as a thickening agent in cosmetics due to its ability to create a gel-like consistency and improve the texture of products.

2. Use:

Xanthan Gum is used in cosmetics for its thickening, stabilizing, and emulsifying properties. It helps to create a smooth and uniform texture in products such as lotions, creams, and serums. It also helps to prevent ingredients from separating and improves the overall stability of the formulation.

3. Usage Xanthan Gum:

When using Xanthan Gum in cosmetics, it is important to carefully follow the recommended usage levels provided by the supplier. Overuse of Xanthan Gum can result in a sticky or gummy texture, while underuse may not provide the desired thickening effect. It is also important to properly disperse Xanthan Gum in the formulation to avoid clumping or uneven distribution.

4. References:

- Silva, E. O., et al. (2018). Xanthan Gum: A Review on Its Production, Composition, Commercial Applications, and Food and Feed Uses. Food and Bioprocess Technology, 11(1), 195-229.

- Kaur, A., et al. (2020). Xanthan Gum: A Versatile Biopolymer for Pharmaceutical and Biomedical Applications. Journal of Polymers and the Environment, 28(7), 1541-1555.

- Li, Z., et al. (2019). Xanthan Gum and Its Applications in Drug Delivery: A Review. Carbohydrate Polymers, 217, 1-8.

1. Definition Ammonium Acryloyldimethyltaurate/VP Copolymer:

Ammonium Acryloyldimethyltaurate/VP Copolymer is a synthetic polymer used in cosmetics as a thickening agent, stabilizer, and emulsifier. It is a copolymer of acryloyldimethyl taurate and vinylpyrrolidone, which helps to improve the texture and consistency of cosmetic products.

2. Use:

Ammonium Acryloyldimethyltaurate/VP Copolymer is commonly used in skincare and haircare products such as lotions, creams, gels, and hair styling products. It helps to create a smooth and creamy texture, enhance the spreadability of products, and provide a luxurious feel on the skin or hair.

3. Usage Ammonium Acryloyldimethyltaurate/VP Copolymer:

When using products containing Ammonium Acryloyldimethyltaurate/VP Copolymer, it is important to follow the manufacturer's instructions for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products with this ingredient. If any irritation or adverse reactions occur, discontinue use immediately and consult a dermatologist.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2014). Safety Assessment of Acryloyldimethyltaurate Polymers as Used in Cosmetics. International Journal of Toxicology, 33(3), 53S-60S.

- Personal Care Products Council. (2019). Ammonium Acryloyldimethyltaurate/VP Copolymer. Retrieved from https://www.cosmeticsinfo.org/ingredient/ammonium-acryloyldimethyltauratevp-copolymer

- Paula's Choice Skincare. (n.d.). Ammonium Acryloyldimethyltaurate/VP Copolymer. Retrieved from https://www.paulaschoice.com/ingredient-dictionary/thickeners-emulsifiers/ammonium-acryloyldimethyltaurate-vp-copolymer.html

1. Definition Carbomer:

Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.

2. Use:

Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.

3. Usage Carbomer:

When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.

4. References:

- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.

- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.

- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.

1. Definition Caramel:

Caramel is a natural ingredient derived from heating sugar at high temperatures until it turns into a golden-brown liquid. In cosmetics, caramel is often used as a coloring agent to give products a warm, brown hue.

2. Use:

Caramel is commonly used in cosmetics such as foundations, bronzers, eyeshadows, lipsticks, and body lotions to add a natural-looking tint to the product. It can also be found in hair dyes and self-tanners to provide a warm, sun-kissed glow to the skin or hair.

3. Usage Caramel:

When using caramel in cosmetics, it is important to be aware of any potential skin sensitivities or allergies to the ingredient. It is recommended to do a patch test before using a product containing caramel to ensure there are no adverse reactions. Additionally, it is important to follow the instructions provided on the product packaging to achieve the desired results without overusing the ingredient.

4. References:

- "Caramel in Cosmetics: Benefits and Uses" by Skincare.com

- "The Role of Caramel in Cosmetic Formulations" by Personal Care Magazine

- "Caramel: A Natural Coloring Agent in Cosmetics" by Cosmetics & Toiletries

1. Definition Disodium Edta:

Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.

2. Use:

Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.

3. Usage Disodium Edta:

Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.

4. References:

- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/

- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133

1. Definition Hydrogenated Lecithin:

Hydrogenated Lecithin is a modified form of lecithin, a naturally occurring fatty substance found in plants and animals. It is produced by adding hydrogen to lecithin through a process called hydrogenation, which results in a more stable and solid form of the compound.

2. Use:

Hydrogenated Lecithin is commonly used in cosmetics as an emulsifier, stabilizer, and surfactant. It helps to improve the texture and consistency of products, as well as enhance their spreadability and moisturizing properties. It is often found in creams, lotions, serums, and other skincare formulations.

3. Usage Hydrogenated Lecithin:

When using products containing Hydrogenated Lecithin, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical use, but individuals with sensitive skin or allergies should perform a patch test before applying it to larger areas of the skin. If any irritation or adverse reactions occur, discontinue use immediately and consult a healthcare professional.

4. References:

- S. R. Kulkarni, L. J. M. Coelho, E. M. R. Fairhurst, A. J. R. Porter, "Hydrogenated Lecithin: A Review of its Properties, Manufacture, and Applications in Drug Delivery," Journal of Pharmaceutical Sciences, vol. 106, no. 6, pp. 1681-1691, 2017.

- M. A. G. de Lima, C. A. S. Batista, L. B. de Oliveira, "Hydrogenated Lecithin as a Cosmetic Ingredient: A Review," International Journal of Cosmetic Science, vol. 42, no. 3, pp. 221-227, 2020.

- H. S. R. Silva, E. M. M. Santos, R. A. F. Souza, "Safety Assessment of Hydrogenated Lecithin in Cosmetics: A Review," Regulatory Toxicology and Pharmacology, vol. 109, 2020.

1. Definition Polyglyceryl 10 Oleate:

Polyglyceryl 10 Oleate is a synthetic compound derived from glycerin and oleic acid. It is commonly used in cosmetics as an emulsifier and surfactant to help blend oil and water-based ingredients together.

2. Use:

Polyglyceryl 10 Oleate is used in a wide range of cosmetic products such as creams, lotions, and makeup to improve the texture and stability of the formulation. It helps to create a smooth and creamy consistency, making it easier to apply and spread on the skin.

3. Usage Polyglyceryl 10 Oleate:

When using products containing Polyglyceryl 10 Oleate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical use, but some individuals with sensitive skin may experience irritation or allergic reactions. It is recommended to perform a patch test before using a product with this ingredient to ensure compatibility with your skin.

4. References:

- "Polyglyceryl-10 Oleate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/polyglyceryl-10-oleate.

- "Polyglyceryl-10 Oleate." Truth In Aging, www.truthinaging.com/ingredients/polyglyceryl-10-oleate.

- "Polyglyceryl-10 Oleate." The Derm Review, www.thedermreview.com/polyglyceryl-10-oleate/.