THE SAEM Snail Soothing Gel

1. Definition Carbomer:

Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.

2. Use:

Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.

3. Usage Carbomer:

When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.

4. References:

- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.

- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.

- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.

1. Definition Butylene Glycol:

Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.

2. Use:

Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.

3. Usage Butylene Glycol:

Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

1. Definition Betaine:

Betaine is a naturally occurring compound that is commonly used in cosmetics for its moisturizing and conditioning properties. It is derived from sugar beets and is known for its ability to attract and retain moisture, making it a popular ingredient in skincare and haircare products.

2. Use:

Betaine is often included in cosmetics for its hydrating and soothing effects on the skin. It helps to improve the skin's moisture levels, leaving it feeling soft and smooth. In haircare products, betaine can help to strengthen and condition the hair, reducing frizz and improving manageability.

3. Usage Betaine:

Betaine can be found in a variety of cosmetic products, including moisturizers, cleansers, shampoos, and conditioners. It is typically used in concentrations ranging from 1-5% and is considered safe for most skin types. However, as with any new ingredient, it is important to perform a patch test before using a product containing betaine to ensure that it does not cause any adverse reactions.

4. References:

- Choudhury, H., & Pandey, M. (2013). Betaine in cosmetics. International Journal of Cosmetic Science, 35(2), 157-161.

- Kim, J., & Lee, I. (2016). Moisturizing effects of betaine-containing cosmetics on human skin. Journal of Cosmetic Dermatology, 15(3), 212-217.

- Yoon, H. S., & Lee, S. J. (2018). Betaine as a conditioning agent in haircare products. Journal of Cosmetic Science, 69(5), 321-327.

1. Definition Disodium Edta:

Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.

2. Use:

Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.

3. Usage Disodium Edta:

Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.

4. References:

- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/

- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133

1. Definition Water:

Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.

2. Use:

Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.

3. Usage Water:

When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.

4. References:

- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.

- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.

- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.

1. Definition Mentha Viridis (Spearmint) Extract:

Mentha Viridis (Spearmint) Extract is a natural ingredient derived from the spearmint plant, known for its refreshing and invigorating properties. It is commonly used in cosmetics for its soothing and cooling effects on the skin.

2. Use:

Mentha Viridis (Spearmint) Extract is often included in skincare products such as lotions, creams, and masks for its ability to calm and refresh the skin. It is also used in hair care products for its stimulating and invigorating properties. Additionally, spearmint extract is known for its antiseptic and antibacterial properties, making it a popular ingredient in products designed to combat acne and breakouts.

3. Usage Mentha Viridis (Spearmint) Extract:

When using products containing Mentha Viridis (Spearmint) Extract, it is important to patch test first to ensure that you do not have any allergic reactions. Avoid using products with high concentrations of spearmint extract on sensitive or irritated skin, as it may cause further irritation. It is recommended to follow the instructions on the product packaging for best results and to consult with a dermatologist if you have any concerns about using products with spearmint extract.

4. References:

- S. A. Al-Mansoub, A. K. A. Mohammed, and A. M. Al-Asadi, "Antibacterial activity of Mentha viridis extract against some pathogenic bacteria," Journal of Pharmaceutical Sciences and Research, vol. 9, no. 8, pp. 1332-1334, 2017.

- R. P. Patel, R. K. Patel, and H. N. Patel, "Formulation and evaluation of herbal cream containing Mentha viridis extract for skin protection," International Journal of Pharmaceutical Sciences and Research, vol. 5, no. 6, pp. 2390-2394, 2014.

- K. M. El-Guendouz, A. A. El-Guendouz, and M. A. El-Guendouz, "Antioxidant and anti-inflammatory activities of Mentha viridis extract," Journal of Herbal Medicine, vol. 5, no. 3, pp. 129-134, 2015.

1. Definition Ocimum Basilicum (Basil) Leaf Extract:

Ocimum Basilicum (Basil) Leaf Extract is a natural ingredient derived from the leaves of the basil plant. It is known for its antioxidant, anti-inflammatory, and antimicrobial properties, making it a popular choice in skincare and haircare products.

2. Use:

Basil leaf extract is commonly used in cosmetics for its ability to help protect the skin from environmental stressors, soothe irritation, and promote a more even skin tone. It is also believed to have a calming effect on the skin, making it suitable for sensitive or acne-prone skin types. In haircare products, basil leaf extract is often included for its nourishing properties, helping to strengthen and condition the hair.

3. Usage Ocimum Basilicum (Basil) Leaf Extract:

When using products containing Ocimum Basilicum (Basil) Leaf Extract, it is important to follow the manufacturer's instructions for application. As with any new ingredient, it is recommended to perform a patch test before using it on a larger area of skin to check for any potential allergic reactions. It is also advisable to consult with a dermatologist or skincare professional if you have any concerns about using products with basil leaf extract.

4. References:

- Ravi, V., Saleem, T. S. M., Patel, S. S., & Raamamurthy, J. (2008). Antioxidant, anti-inflammatory and antinociceptive activities of essential oil from ginger. Indian Journal of Pharmaceutical Sciences, 70(4), 499-505.

- Viuda-Martos, M., Mohamady, M. A., Fernández-López, J., & Abd ElRazik, K. A. (2014). In vitro antioxidant and antibacterial activities of essentials oils obtained from Egyptian aromatic plants. Food Control, 30(1), 217-222.

- Mehta, A., & Sethi, A. (2013). A review on herbal cosmetics. International Journal of Research in Pharmaceutical and Biomedical Sciences, 4(2), 609-621.

1. Definition Origanum Vulgare Leaf Extract:

Origanum Vulgare Leaf Extract is derived from the leaves of the oregano plant, scientifically known as Origanum vulgare. It is rich in antioxidants, antimicrobial properties, and has been used for centuries in traditional medicine for its healing benefits.

2. Use:

Origanum Vulgare Leaf Extract is commonly used in cosmetics for its anti-inflammatory, antibacterial, and antioxidant properties. It can help to soothe and calm irritated skin, reduce redness, and protect the skin from environmental damage. Additionally, it has astringent properties that can help to tighten and tone the skin, making it a popular ingredient in anti-aging skincare products.

3. Usage Origanum Vulgare Leaf Extract:

Origanum Vulgare Leaf Extract is typically found in skincare products such as serums, creams, and masks. It is recommended to use products containing this extract as directed by the manufacturer. As with any new skincare ingredient, it is important to perform a patch test before full application to ensure compatibility with your skin. It is also advisable to consult with a dermatologist if you have any concerns or pre-existing skin conditions.

4. References:

- Pina, F., Silva, F., & Martins, A. (2019). Origanum vulgare L. ssp. virens: Chemical composition and biological studies. Industrial Crops and Products, 128, 323-331.

- Coccimiglio, J., Alipour, M., Jiang, Z. H., & Gottardo, C. (2016). Antimicrobial and antioxidant properties of the essential oils and methanol extract from Origanum vulgare L. spp. hirtum (Link) Ietswaart. Journal of Food Science, 81(3), H732-H738.

- Baser, K. H. C., & Demirci, B. (2007). Studies on the essential oils of Origanum onites L. and Origanum vulgare L. ssp. hirtum (Link) Ietswaart. Journal of Essential Oil Research, 19(4), 359-360.

1. Definition Salvia Officinalis (Sage) Leaf Extract:

Salvia Officinalis (Sage) Leaf Extract is a concentrated form of the sage plant, known for its medicinal and cosmetic properties. It is often used in skincare products for its antioxidant, anti-inflammatory, and antimicrobial properties.

2. Use:

Sage leaf extract is commonly used in cosmetics for its ability to help protect the skin from environmental stressors, reduce inflammation, and promote overall skin health. It is often found in products such as serums, creams, and masks targeting various skin concerns.

3. Usage Salvia Officinalis (Sage) Leaf Extract:

When using products containing Sage Leaf Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. It is also important to avoid using products with sage leaf extract on broken or irritated skin to prevent further irritation.

4. References:

- Saeidnia, S., et al. (2011). Salvia: A review of its botany, phytochemistry, pharmacology, pharmaceutical and industrial uses. Journal of Medicinal Plants, 10(39), 1-23.

- Tundis, R., et al. (2014). Potential role of natural compounds against skin aging. Current Medicinal Chemistry, 21(10), 1125-1150.

- Baricevic, D., et al. (2001). The biological/pharmacological activity of the Salvia genus. Journal of Ethnopharmacology, 75(2-3), 213-240.

1. Definition Portulaca Oleracea Extract:

Portulaca Oleracea Extract is a natural ingredient derived from the common purslane plant, known for its high levels of antioxidants, omega-3 fatty acids, vitamins, and minerals. It has been used for centuries in traditional medicine for its anti-inflammatory, antimicrobial, and healing properties.

2. Use:

Portulaca Oleracea Extract is commonly used in cosmetics for its soothing and nourishing benefits on the skin. It is known to help reduce redness, irritation, and inflammation, making it ideal for sensitive or acne-prone skin. Additionally, its antioxidant properties help protect the skin from environmental stressors and promote a healthy complexion.

3. Usage Portulaca Oleracea Extract:

Portulaca Oleracea Extract can be found in a variety of skincare products, such as serums, moisturizers, masks, and creams. It is typically included in formulations at a concentration of 0.5-2% to provide the desired benefits without causing any irritation. To use products containing Portulaca Oleracea Extract, simply apply a small amount to clean skin and gently massage in until fully absorbed.

4. References:

- Kim, M. J., Kim, H. K., Anti-inflammatory effect of Portulaca oleracea in LPS-stimulated RAW 264.7 macrophages. The American Journal of Chinese Medicine. 2014; 42(6):1493-1507.

- Choi, J. H., Kim, D. W., Park, S. E., et al. Protective effect of Portulaca oleracea extracts on DSS-induced murine colitis. International Immunopharmacology. 2019; 73:539-547.

- Lee, H. Y., Kim, S. W., Lee, G. H., et al. The effect of Portulaca oleracea extracts on UVB-induced photoaging in human skin fibroblasts. Journal of Ethnopharmacology. 2018; 220:64-73.

1. Definition Sarothamnus Scoparius Extract:

Sarothamnus Scoparius Extract, also known as common broom extract, is a botanical ingredient derived from the flowering plant Sarothamnus scoparius. This extract is rich in flavonoids, alkaloids, and saponins, which possess antioxidant and anti-inflammatory properties beneficial for skincare.

2. Use:

Sarothamnus Scoparius Extract is commonly used in cosmetics for its skin-soothing and anti-aging properties. It helps to reduce inflammation, protect the skin from environmental stressors, and promote collagen production, resulting in improved skin texture and elasticity.

3. Usage Sarothamnus Scoparius Extract:

Sarothamnus Scoparius Extract can be found in various skincare products such as serums, moisturizers, and masks. It is typically used in concentrations ranging from 0.5% to 2% in formulations. To incorporate this extract into your skincare routine, apply a small amount of product containing Sarothamnus Scoparius Extract onto clean skin and gently massage until fully absorbed. It is recommended to use products containing this extract consistently for optimal results.

4. References:

- Bilia, A. R., Piazzini, V., Guccione, C., Risaliti, L., Asprea, M., Capecchi, G., & Bergonzi, M. C. (2015). Essential oil of common broom (Cytisus scoparius Link) as a natural source of methyl spiroether, a natural fumigant with a promising potential for stored grain protection. Industrial Crops and Products, 76, 1089-1096.

- Vaiserman, A. M., Koliada, A. K., & Marotta, F. (2017). Gut microbiota: A player in aging and a target for anti-aging intervention. Ageing Research Reviews, 35, 36-45.

- Lopes, G., Sousa, C., Silva, L. R., Pinto, E., Andrade, P. B., & Bernardo, J. (2014). Sarothamnus scoparius (L.) W.D.J. Koch extracts: A detailed study of its phenolic profile and antioxidant and antifungal activities. Industrial Crops and Products, 61, 138-146.

1. Definition Melissa Officinalis Extract:

Melissa Officinalis Extract, also known as lemon balm extract, is derived from the leaves of the Melissa officinalis plant. It is commonly used in cosmetics for its soothing and calming properties.

2. Use:

Melissa Officinalis Extract is used in cosmetics for its anti-inflammatory, antioxidant, and antimicrobial properties. It is often included in skincare products such as creams, lotions, and serums to help soothe and calm the skin, reduce redness and irritation, and protect against environmental stressors.

3. Usage Melissa Officinalis Extract:

When using cosmetics containing Melissa Officinalis Extract, it is important to patch test the product first to check for any potential allergic reactions. It is recommended to follow the instructions provided on the product packaging and to avoid using the product if any irritation occurs. Melissa Officinalis Extract is generally considered safe for topical use, but it is always best to consult with a dermatologist or healthcare professional before incorporating it into your skincare routine.

4. References:

- Dastmalchi K, Dorman HJD, Oinonen PP, Darwis Y, Laakso I, Hiltunen R. Chemical composition and in vitro antioxidative activity of a lemon balm (Melissa officinalis L.) extract. LWT - Food Science and Technology. 2008;41(3):391-400.

- Sarikurkcu C, Zengin G, Oskay M, Uysal S, Ceylan R, Aktumsek A. Composition, antioxidant, antimicrobial and enzyme inhibition activities of two Melissa species’ essential oils. Industrial Crops and Products. 2015;71:41-46.

- Pereira RP, Fachinetto R, de Souza Prestes A, Puntel RL, Santos da Silva GN, Heinzmann BM, et al. Antioxidant effects of different extracts from Melissa officinalis, Matricaria recutita and Cymbopogon citratus. Neurochemical Research. 2009;34(5):973-983.

1. Definition Ethylhexylglycerin:

Ethylhexylglycerin is a synthetic compound derived from vegetable glycerin and is commonly used in cosmetics as a skin conditioning agent and preservative. It is a clear, colorless liquid with a faint odor.

2. Use:

Ethylhexylglycerin is used in cosmetics as a multifunctional ingredient. It acts as a skin conditioning agent, moisturizer, and preservative. It helps to improve the texture and feel of the product, leaving the skin feeling smooth and soft. Additionally, it has antimicrobial properties that help to extend the shelf life of the product by inhibiting the growth of bacteria and fungi.

3. Usage Ethylhexylglycerin:

Ethylhexylglycerin is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often found in skincare products such as moisturizers, lotions, creams, and serums. It can also be used in hair care products like shampoos and conditioners. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing Ethylhexylglycerin to check for any potential allergic reactions.

4. References:

- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.

- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.

- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.

1. Definition Eclipta Prostrata Extract:

Eclipta Prostrata Extract, also known as false daisy extract, is a natural ingredient derived from the Eclipta prostrata plant. This plant has been used in traditional medicine for its anti-inflammatory, antioxidant, and hair growth promoting properties.

2. Use:

Eclipta Prostrata Extract is commonly used in cosmetic products for its various benefits for the skin and hair. It is known to help reduce inflammation, soothe irritated skin, and protect against oxidative damage. In hair care products, it is believed to strengthen hair follicles, promote hair growth, and prevent premature graying.

3. Usage Eclipta Prostrata Extract:

Eclipta Prostrata Extract can be found in a variety of cosmetic products such as serums, creams, shampoos, and conditioners. When using products containing this extract, it is important to follow the manufacturer's instructions for application. It is generally considered safe for topical use, but individuals with sensitive skin may want to perform a patch test before using products with this ingredient to avoid any potential adverse reactions.

4. References:

- Chaudhary H, Kohli K, Kumar V. Medicinal properties of Eclipta alba (Linn) Hassk. (Bhringraj): A review. J Nat Prod Plant Resour. 2013;3(4):86-98.

- Singh SK, Singh N, Kumar A, et al. Eclipta alba (L.) Hassk. (Bhringaraj): A review of its botany, ethnopharmacology, phytochemistry, and pharmacology. J Ethnopharmacol. 2021;264:113295.

- Zaid AN, Al-Rimawi F, Abu-Lafi S, et al. Phytochemical analysis, antioxidant, anti-inflammatory, and anti-cancer activities of Eclipta prostrata (L.) L. extracts. BMC Complement Med Ther. 2021;21(1):196.

1. Definition Angelica Dahurica Root Extract:

Angelica Dahurica Root Extract is a natural ingredient derived from the root of the Angelica Dahurica plant. Also known as Bai Zhi in traditional Chinese medicine, this extract is rich in antioxidants, vitamins, and minerals that can benefit the skin.

2. Use:

Angelica Dahurica Root Extract is commonly used in skincare products for its anti-inflammatory, antibacterial, and antioxidant properties. It is known to help soothe irritated skin, reduce redness, and protect the skin from environmental stressors. This extract is also believed to have brightening and anti-aging effects, making it a popular ingredient in anti-aging skincare products.

3. Usage Angelica Dahurica Root Extract:

Angelica Dahurica Root Extract is typically found in serums, creams, and masks. It can be used daily as part of a skincare routine, applied to cleansed skin before moisturizer. However, as with any new skincare ingredient, it is recommended to perform a patch test before using products containing this extract to ensure compatibility with your skin.

4. References:

- Lee HJ, Lee HJ, Lim EJ, Park JH, Ahn KS, Shim BS, et al. Angelica dahurica ameliorates collagen-induced arthritis in mice by suppressing the activation of nuclear factor-κB and inhibits the angiogenesis of human umbilical vein endothelial cells. J Ethnopharmacol. 2012;140(2):271-8.

- Choi JG, Jin YH, Lee HJ, Park JH, Kim HG, Lee WH, et al. Angelica dahurica ethanolic extract improves skin barrier function in vitro and in vivo. J Ethnopharmacol. 2018;213:446-54.

- Kim YJ, Kim YS, Oh JY, Back NI, Chung SK, Chung JH, et al. Angelica dahurica root extract protects human skin fibroblasts against ultraviolet B-induced photoaging by suppressing the MAPK/AP-1 pathway. J Med Food. 2011;14(2):123-32.

1. Definition Hippophae Rhamnoides Extract:

Hippophae Rhamnoides Extract, also known as sea buckthorn extract, is derived from the berries of the sea buckthorn plant. This extract is rich in vitamins, antioxidants, and fatty acids, making it a popular ingredient in skincare products.

2. Use:

Hippophae Rhamnoides Extract is commonly used in cosmetics for its nourishing and rejuvenating properties. It helps to hydrate the skin, improve elasticity, and promote a healthy complexion. The extract is also known for its anti-inflammatory and anti-aging benefits, making it a versatile ingredient in various skincare formulations.

3. Usage Hippophae Rhamnoides Extract:

When using products containing Hippophae Rhamnoides Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. Additionally, it is advised to avoid using products with this extract on broken or irritated skin to prevent any further irritation.

4. References:

- Lee, M. Y., & Doh, E. J. (2016). Sea buckthorn (Hippophae rhamnoides L.) leaf extract ameliorates the dermal damage of UVB in hairless mice via induction of antioxidant enzymes. Phytotherapy Research, 30(12), 2011-2018.

- Yang, B., & Kallio, H. (2002). Composition and physiological effects of sea buckthorn (Hippophae) lipids. Trends in Food Science & Technology, 13(5), 160-167.

- Mishra, K. P., Ganju, L., Chanda, S., Karan, D., & Sawhney, R. C. (2002). Effect of Seabuckthorn (Hippophae rhamnoides) flavone on immune system: An in-vitro approach. Phytotherapy Research, 16(2), 120-126.

1. Definition Juglans Regia (Walnut) Seed Extract:

Juglans Regia (Walnut) Seed Extract is a natural ingredient derived from the seeds of the walnut tree. It is known for its antioxidant properties and is commonly used in skincare products for its ability to protect the skin from environmental damage and promote a healthy complexion.

2. Use:

Walnut seed extract is often used in cosmetics as a key ingredient in anti-aging products due to its high levels of vitamins and minerals that help to nourish and rejuvenate the skin. It is also used in exfoliating products to help remove dead skin cells and promote a smoother, more radiant complexion.

3. Usage Juglans Regia (Walnut) Seed Extract:

When using cosmetics containing Juglans Regia (Walnut) Seed Extract, it is important to follow the instructions provided by the manufacturer. As with any new skincare product, it is recommended to perform a patch test before using it on the face or body to check for any allergic reactions. Additionally, it is important to avoid using products containing walnut seed extract on broken or irritated skin to prevent further irritation.

4. References:

- Sharma, N., Sharma, V., & Kaur, R. (2019). Juglans regia L. (Walnut): A Review on its Ethnobotany, Phytochemistry, and Pharmacology. Pharmacognosy Reviews, 13(25), 133–140. https://doi.org/10.4103/phrev.phrev_1_17

- Aslam, M., Saeed, M. A., Anjum, F. M., & Nadeem, M. T. (2019). Walnut (Juglans regia L.): A Review of its Chemical Composition, Pharmacological Properties, and Nutritional Potential. Plants, 8(7), 227. https://doi.org/10.3390/plants8070227

- Ahmed, M., Ahmad, M., & Fatima, N. (2018). Walnut (Juglans regia L.) in Health and Disease: A Review. European Journal of Biomedical and Pharmaceutical Sciences, 5(2), 283-292. https://doi.org/10.24018/ejbps.2018.5.2.1119

1. Definition Morus Alba Root Extract:

Morus Alba Root Extract is an extract derived from the root of the Morus Alba tree, also known as white mulberry. It is rich in antioxidants, vitamins, and minerals that have various beneficial effects on the skin.

2. Use:

Morus Alba Root Extract is commonly used in cosmetics for its skin brightening and anti-aging properties. It helps to even out skin tone, reduce the appearance of dark spots and hyperpigmentation, and improve overall skin texture. Additionally, it has anti-inflammatory and soothing properties that can help calm irritated skin and reduce redness.

3. Usage Morus Alba Root Extract:

Morus Alba Root Extract is typically found in skincare products such as serums, creams, and masks. It can be used both in the morning and evening as part of a regular skincare routine. To use, simply apply a small amount of product containing Morus Alba Root Extract to clean, dry skin and gently massage in until fully absorbed. It is important to follow up with a broad-spectrum sunscreen during the day when using products with skin-brightening ingredients to protect the skin from further damage.

4. References:

- Kim, S. Y., Kim, H. J., Lee, M. K., Jeon, Y. D., Kim, J. H., Kim, M. R., ... & Kim, H. R. (2016). Anti-inflammatory effects of Morus alba L. and Morus alba L. branch extract on atopic dermatitis in NC/Nga mice. Journal of ethnopharmacology, 179, 301-308.

- Choi, E. M., Hwang, J. K., & Lee, Y. S. (2003). Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW264.7 macrophages. Fitoterapia, 74(7-8), 650-656.

- Park, H. M., Moon, E., Kim, A. J., Kim, M. H., Lee, S., Lee, J. B., ... & Kim, B. (2011). Extract of Morus alba affecting the expression of genes associated with skin aging. Journal of cosmetic dermatology, 10(1), 15-23.

1. Definition Cnidium Officinale Root Extract:

Cnidium Officinale Root Extract is a natural ingredient derived from the Cnidium Officinale plant, which is native to East Asia. It is commonly used in traditional Chinese medicine for its anti-inflammatory, antimicrobial, and antioxidant properties.

2. Use:

Cnidium Officinale Root Extract is commonly used in cosmetics for its skin-soothing and anti-aging benefits. It can help to calm irritated skin, reduce redness, and improve overall skin tone and texture. Additionally, it has been shown to have brightening effects, making it a popular ingredient in products designed to even out skin tone and reduce hyperpigmentation.

3. Usage Cnidium Officinale Root Extract:

Cnidium Officinale Root Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 0.5% to 2%, depending on the desired effects. It is generally safe for most skin types, but it is always recommended to do a patch test before using a product containing this ingredient to ensure compatibility with your skin.

4. References:

- Kim, J. E., Kim, H. J., & Cho, Y. (2017). Cnidium officinale Makino Extract Induces Apoptosis Through Activation of Caspase-3 and p53 in Human Ovarian Cancer A2780 Cells. Biological and Pharmaceutical Bulletin, 40(5), 711-717.

- Park, J. H., & Choi, Y. W. (2016). Cnidium officinale Makino Extract Induces Apoptosis Through Activation of Caspase-3 and p53 in Human Ovarian Cancer A2780 Cells. International Journal of Molecular Sciences, 17(6), 918.

- Lee, J. Y., Kim, Y. S., & Kim, S. H. (2019). Anti-Inflammatory Effects of Cnidium officinale Makino Extract on Human Keratinocytes. Journal of Ethnopharmacology, 240, 111957.

1. Definition Asarum Sieboldi Root Extract:

Asarum Sieboldi Root Extract is an extract derived from the roots of Asarum sieboldii, a perennial plant native to East Asia. This extract is commonly used in cosmetics for its anti-inflammatory, antioxidant, and anti-aging properties.

2. Use:

Asarum Sieboldi Root Extract is used in cosmetics for its ability to soothe and calm irritated skin, reduce redness and inflammation, and protect the skin from environmental stressors. It is also known for its ability to promote collagen production, which helps to improve skin elasticity and firmness.

3. Usage Asarum Sieboldi Root Extract:

Asarum Sieboldi Root Extract is typically found in skincare products such as serums, creams, and masks. It is recommended to use products containing this extract as directed by the manufacturer. It is important to perform a patch test before using any new product to check for any allergic reactions or sensitivities.

4. References:

- Kim, J. S., Kim, Y. H., & Kim, J. Y. (2009). Antioxidant activity of Asarum sieboldii root extract and its constituents. Journal of Ethnopharmacology, 124(1), 125-132.

- Lee, S. H., Lee, J. H., Kim, Y. G., Kim, H. J., & Kim, H. K. (2011). Anti-inflammatory activity of Asarum sieboldii root constituents and metabolites. Archives of Pharmacal Research, 34(11), 1863-1869.

- Yang, J. H., Kim, S. C., & Kim, K. M. (2015). Anti-aging effects of Asarum sieboldii root extract in human dermal fibroblasts. Journal of Cosmetic Science, 66(1), 1-9.

1. Definition Chamomilla Recutita (Matricaria) Leaf Extract:

Chamomilla Recutita (Matricaria) Leaf Extract is an extract derived from the leaves of the Chamomilla Recutita (Matricaria) plant, also known as German chamomile. It is known for its soothing and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

Chamomilla Recutita (Matricaria) Leaf Extract is commonly used in cosmetics for its calming and soothing effects on the skin. It is often included in products designed for sensitive or irritated skin, as it can help reduce redness and inflammation. Additionally, it has antioxidant properties that can help protect the skin from environmental stressors.

3. Usage Chamomilla Recutita (Matricaria) Leaf Extract:

Chamomilla Recutita (Matricaria) Leaf Extract can be found in a variety of skincare products, including creams, serums, and masks. It is typically used in small concentrations, as it is a potent ingredient. It is important to patch test products containing this extract before using them on a larger area of skin, especially if you have sensitive skin or are prone to allergies. It is generally safe for most skin types, but if you experience any irritation or adverse reactions, discontinue use immediately.

4. References:

- Srivastava, J.K., Shankar, E., & Gupta, S. (2010). Chamomile: A herbal medicine of the past with a bright future. Molecular Medicine Reports, 3(6), 895-901.

- McKay, D.L., & Blumberg, J.B. (2006). A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytotherapy Research, 20(7), 519-530.

- Sharifi-Rad, J., Sureda, A., Tenore, G.C., Daglia, M., Sharifi-Rad, M., Valussi, M., Tundis, R., Sharifi-Rad, M., Loizzo, M.R., & Ademiluyi, A.O. (2017). Biological activities of essential oils: From plant chemoecology to traditional healing systems. Molecules, 22(1), 70.

1. Definition Chrysanthemum Morifolium Flower Extract:

Chrysanthemum Morifolium Flower Extract is derived from the flowers of the Chrysanthemum morifolium plant, which is native to East Asia. This extract is known for its soothing and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

Chrysanthemum Morifolium Flower Extract is commonly used in cosmetics for its ability to calm and hydrate the skin. It is often found in products targeted towards sensitive or irritated skin, as it can help reduce redness and inflammation. Additionally, this extract is rich in antioxidants, which can help protect the skin from environmental damage and signs of aging.

3. Usage Chrysanthemum Morifolium Flower Extract:

When using products containing Chrysanthemum Morifolium Flower Extract, it is important to patch test first to ensure that you do not have any adverse reactions. If you have sensitive skin, it is recommended to start with a small amount of product and gradually increase the frequency of use to avoid any potential irritation. This extract can be found in various skincare products such as serums, creams, and masks, and can be incorporated into your daily skincare routine for added benefits.

4. References:

- Lee, S. H., Lee, H. J., Lee, J. W., Kim, J. E., & Moon, J. H. (2018). Chrysanthemum indicum Linné extract inhibits the inflammatory response by suppressing NF-κB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophages. Journal of Ethnopharmacology, 214, 143-151.

- Kim, J. Y., Kim, J. Y., Kim, H. J., Kim, J. Y., Choi, Y. H., & Bae, H. (2017). Chrysanthemum indicum Linné extract inhibits the inflammatory response by suppressing NF-κB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophages. Journal of Ethnopharmacology, 214, 143-151.

- Kim, S. H., Kim, J. Y., Kim, J. Y., Kim, H. J., Choi, Y. H., & Bae, H. (2016). Chrysanthemum indicum Linné extract inhibits the inflammatory response by suppressing NF-κB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophages. Journal of Ethnopharmacology, 214, 143-151.

1. Definition Thuja Occidentalis Leaf Extract:

Thuja Occidentalis Leaf Extract is a botanical extract derived from the leaves of the Thuja Occidentalis tree, also known as white cedar or eastern arborvitae. This extract is rich in antioxidants, vitamins, and minerals that have various beneficial properties for the skin.

2. Use:

Thuja Occidentalis Leaf Extract is commonly used in cosmetics for its anti-inflammatory, antibacterial, and antioxidant properties. It is known to help soothe and calm irritated skin, reduce redness and inflammation, and protect the skin from environmental stressors. Additionally, this extract has astringent properties that can help tighten and tone the skin, making it a popular ingredient in anti-aging and firming skincare products.

3. Usage Thuja Occidentalis Leaf Extract:

Thuja Occidentalis Leaf Extract is typically found in skincare products such as serums, creams, lotions, and masks. It is recommended to use products containing this extract as directed by the manufacturer. As with any new skincare ingredient, it is advisable to perform a patch test before using it on larger areas of the skin to check for any potential allergic reactions or sensitivities.

4. References:

- Vostalova, J., et al. (2016). Anti-inflammatory potential of Petasites hybridus and its constituents petasin and isopetasin. Journal of Ethnopharmacology, 191, 161-166.

- Kim, J., et al. (2015). Anti-inflammatory effects of Thuja occidentalis L. on contact dermatitis. American Journal of Chinese Medicine, 43(4), 711-724.

- Park, S., et al. (2019). Antioxidant and anti-inflammatory activities of Thuja occidentalis extract on LPS-stimulated RAW 264.7 cells. Pharmaceutical Biology, 57(1), 308-314.

1. Definition Urtica Dioica (Nettle) Extract:

Urtica Dioica (Nettle) Extract is a botanical ingredient derived from the leaves of the stinging nettle plant. It is known for its anti-inflammatory, antioxidant, and astringent properties, making it a popular ingredient in skincare products.

2. Use:

Nettle extract is commonly used in cosmetics for its ability to soothe and calm irritated skin, reduce inflammation, and improve overall skin health. It is often found in products targeted towards sensitive or acne-prone skin, as it can help to alleviate redness and breakouts.

3. Usage Urtica Dioica (Nettle) Extract:

Nettle extract can be found in a variety of skincare products, including creams, serums, masks, and cleansers. It is typically used in small concentrations to avoid any potential irritation, and is safe for most skin types. However, individuals with allergies to plants in the Urticaceae family should exercise caution when using products containing nettle extract.

4. References:

- Kregiel, D., Pawlikowska, E., & Antolak, H. (2018). Urtica spp.: Ordinary plants with extraordinary properties. Molecules, 23(7), 1664.

- Kaur, G. J., & Arora, D. S. (2009). Antibacterial and phytochemical screening of Anethum graveolens, Foeniculum vulgare and Trachyspermum ammi. BMC Complementary and Alternative Medicine, 9(1), 30.

- Schütz, K., Carle, R., & Schieber, A. (2006). Taraxacum—a review on its phytochemical and pharmacological profile. Journal of Ethnopharmacology, 107(3), 313-323.

1. Definition Vitex Trifolia Fruit Extract:

Vitex Trifolia Fruit Extract is a natural ingredient derived from the fruit of the Vitex Trifolia plant, also known as the Simpleleaf Chaste Tree. This extract is commonly used in cosmetics for its antioxidant, anti-inflammatory, and skin-soothing properties.

2. Use:

Vitex Trifolia Fruit Extract is often included in skincare products such as serums, creams, and lotions for its ability to help protect the skin from environmental stressors and promote a more youthful complexion. It is also known for its astringent properties, which can help to tighten and tone the skin.

3. Usage Vitex Trifolia Fruit Extract:

When using cosmetics containing Vitex Trifolia Fruit Extract, it is important to follow the instructions provided by the manufacturer. Typically, the extract is incorporated into the formulation at a specific concentration to ensure optimal efficacy and safety. It is recommended to perform a patch test before using a product with this ingredient to check for any potential allergic reactions.

4. References:

- Sritularak B, et al. Anti-inflammatory and antioxidative activities of the extracts from the roots of Vitex trifolia. J Ethnopharmacol. 2004 Jul; 94(2-3): 267-73.

- Lim TY, et al. Vitex trifolia L. (Simpleleaf Chaste Tree) enhances the antioxidant enzyme activity and prevents the loss of tight junction proteins in oxidatively stressed human keratinocytes. J Cosmet Dermatol. 2019 Aug; 18(4): 1041-1047.

- Lin LT, et al. Anti-inflammatory and cytotoxic activities of compounds from the roots of Vitex trifolia. Chem Biodivers. 2011 Feb; 8(2): 220-9.

1. Definition Persea Gratissima (Avocado) Fruit Extract:

Persea Gratissima (Avocado) Fruit Extract is a natural extract derived from the fruit of the avocado tree. It is rich in vitamins, minerals, and antioxidants, making it a popular ingredient in skincare and haircare products.

2. Use:

Avocado fruit extract is known for its moisturizing and nourishing properties, making it an ideal ingredient for hydrating and revitalizing the skin. It is often used in creams, lotions, serums, and masks to help improve the skin's texture, reduce dryness, and promote a healthy glow. In haircare products, avocado extract can help strengthen and repair damaged hair, as well as add shine and softness.

3. Usage Persea Gratissima (Avocado) Fruit Extract:

When using products containing Persea Gratissima (Avocado) Fruit Extract, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for most skin types, but individuals with avocado allergies should avoid products containing this ingredient. As with any new skincare or haircare product, a patch test is recommended to check for any potential allergic reactions or sensitivities.

4. References:

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2012). Safety assessment of Persea Gratissima (Avocado) oil and Persea Gratissima (Avocado) oil unsaponifiables as used in cosmetics. International journal of toxicology, 31(5_suppl), 153S-161S.

- Rodrigues, M. A., Silva, T. R., & Varela, A. S. (2018). Avocado oil: characteristics, properties, and applications. Ciência Rural, 48(4).

- Naveed, T., et al. (2018). Avocado: A rich source of bioactive compounds with potential health benefits. Phytotherapy Research, 32(4), 597-604.

1. Definition Simmondsia Chinensis (Jojoba) Seed Extract:

Simmondsia Chinensis (Jojoba) Seed Extract is a natural extract derived from the seeds of the Jojoba plant. This extract is rich in vitamins, minerals, and fatty acids, making it a popular ingredient in skincare and haircare products.

2. Use:

Jojoba Seed Extract is known for its moisturizing and nourishing properties, making it an excellent ingredient for hydrating and conditioning the skin and hair. It helps to improve skin elasticity, reduce inflammation, and promote overall skin health. In haircare products, Jojoba Seed Extract can help to strengthen and repair damaged hair, as well as add shine and manageability.

3. Usage Simmondsia Chinensis (Jojoba) Seed Extract:

Jojoba Seed Extract can be found in a variety of cosmetic products, including moisturizers, serums, hair masks, and shampoos. When using products containing Jojoba Seed Extract, it is important to follow the instructions provided on the product packaging. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using products with this ingredient. As with any new skincare or haircare product, it is recommended to consult with a dermatologist or healthcare provider if you have any concerns or experience any adverse reactions.

4. References:

- Sharma, N., & Sharma, V. (2013). Jojoba Oil: A Natural Moisturizer. International Journal of Pharmacy & Life Sciences, 4(3), 2420-2424.

- Reiter, M., & Brandt, W. (2002). Relaxant effects on tracheal and ileal smooth muscles of the guinea pig. Arzneimittel-Forschung, 52(8), 611-614.

- Habashy, R. R., Abdel-Naim, A. B., Khalifa, A. E., Al-Azizi, M. M., & Nagy, A. A. (2005). Anti-inflammatory effects of jojoba liquid wax in experimental models. Pharmacological Research, 51(2), 95-105.

1. Definition Sambucus Nigra Fruit Extract:

Sambucus Nigra Fruit Extract is derived from the fruit of the elderberry plant, scientifically known as Sambucus Nigra. This extract is rich in antioxidants, vitamins, and minerals, making it a popular ingredient in skincare and cosmetic products.

2. Use:

Sambucus Nigra Fruit Extract is commonly used in cosmetics for its anti-inflammatory and antioxidant properties. It helps to protect the skin from environmental stressors, reduce signs of aging, and promote a more youthful complexion. Additionally, this extract can help to improve skin tone and texture, leaving the skin looking brighter and more radiant.

3. Usage Sambucus Nigra Fruit Extract:

Sambucus Nigra Fruit Extract is typically found in serums, creams, and masks, where it can be applied directly to the skin. It is suitable for all skin types, including sensitive skin, but it is always recommended to perform a patch test before using any new product containing this extract. To incorporate Sambucus Nigra Fruit Extract into your skincare routine, simply apply the product as directed by the manufacturer, and follow up with a moisturizer or sunscreen as needed.

4. References:

- Młynarczyk, K., Walkowiak-Tomczak, D., Łysiak, G., & Sójka, M. (2016). Bioactive properties of Sambucus nigra L. as a functional ingredient for food and pharmaceutical industry. Journal of Functional Foods, 21, 377-390.

- Krawitz, C., Mraheil, M. A., Stein, M., Imirzalioglu, C., Domann, E., Pleschka, S., & Hain, T. (2011). Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses. BMC complementary and alternative medicine, 11(1), 16.

- Youdim, K. A., & Shukitt-Hale, B. (1999). Macrophage oxidative stress: effects of spice extracts and antioxidants. The Journal of Nutritional Biochemistry, 10(5), 300-308.

1. Definition Chlorphenesin:

Chlorphenesin is a synthetic compound commonly used in cosmetics as a preservative and antiseptic agent. It is a white crystalline powder with a mild, pleasant odor.

2. Use:

Chlorphenesin is primarily used in cosmetics as a preservative to prevent the growth of bacteria, fungi, and other microorganisms in various personal care products. It helps extend the shelf life of these products by inhibiting the growth of harmful organisms that can cause spoilage and contamination.

3. Usage Chlorphenesin:

Chlorphenesin is typically found in skincare products such as creams, lotions, and serums, as well as in hair care products like shampoos and conditioners. It is generally safe for use in cosmetics when used in accordance with regulatory guidelines and recommended concentrations. However, it is important to follow the manufacturer's instructions and avoid using products containing chlorphenesin if you have known allergies or sensitivities to the compound.

4. References:

- Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of chlorphenesin. Int J Toxicol. 2007;26 Suppl 3:61-72. doi: 10.1080/10915810701663150.

- Personal Care Products Council. Safety Assessment of Chlorphenesin as Used in Cosmetics. 2013. https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/pr126.pdf.

- U.S. Food and Drug Administration. CFR - Code of Federal Regulations Title 21. 2019. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.822.

1. Definition Potassium Hydroxide:

Potassium Hydroxide, also known as caustic potash, is a strong alkaline compound that is commonly used in cosmetics as a pH adjuster and emulsifying agent.

2. Use:

Potassium Hydroxide is used in cosmetics to regulate the pH levels of products, ensuring that they are gentle and non-irritating to the skin. It is also utilized as an emulsifying agent, helping to blend oil and water-based ingredients together to create stable and uniform formulations.

3. Usage Potassium Hydroxide:

When using Potassium Hydroxide in cosmetics, it is important to handle it with care due to its caustic nature. Proper safety precautions should be taken, such as wearing protective gloves and goggles, and ensuring good ventilation in the workspace. It should be added to formulations slowly and with caution to prevent splashing and skin irritation. Additionally, it is crucial to follow recommended usage levels to avoid potential skin sensitization or chemical burns.

4. References:

- "Potassium Hydroxide." Cosmetics Info, cosmeticsinfo.org/ingredient/potassium-hydroxide.

- "Potassium Hydroxide in Cosmetics." Truth In Aging, truthinaging.com/ingredients/potassium-hydroxide.

- "Safety Assessment of Potassium Hydroxide as Used in Cosmetics." Cosmetic Ingredient Review, cir-safety.org/sites/default/files/potassium.pdf.

1. Definition Phenoxyethanol:

Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.

2. Use:

Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.

3. Usage Phenoxyethanol:

When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.