TONYMOLY Regencia Homme Multi Fluid

1. Definition Dimethicone:

Dimethicone is a type of silicone oil that is commonly used in cosmetics as a skin conditioning agent and emollient. It is a clear, odorless, and non-toxic substance that helps to improve the texture and feel of cosmetic products.

2. Use:

Dimethicone is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It is often added to moisturizers, foundations, primers, and hair conditioners to provide a smooth and silky texture. Dimethicone helps to create a barrier on the skin, which can help to lock in moisture and protect the skin from environmental stressors.

3. Usage Dimethicone:

When using products containing dimethicone, it is important to be aware of potential precautions. While dimethicone is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to do a patch test before using a new product containing dimethicone, especially if you have sensitive skin. Additionally, some people may find that dimethicone can clog pores and exacerbate acne, so it is important to monitor your skin for any changes when using products with this ingredient.

4. References:

- Lanigan, R. S., & Yamarik, T. A. (2002). Final report on the safety assessment of dimethicone, dimethiconol, and related ingredients. International journal of toxicology, 21(1), 7-41.

- Draelos, Z. D. (2010). Cosmetic vehicle efficacy. Dermatologic therapy, 23(4), 314-317.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... & Andersen, F. A. (2016). Safety assessment of dimethicone crosspolymers as used in cosmetics. International journal of toxicology, 35(1_suppl), 5S-24S.

1. Definition Betaine:

Betaine is a naturally occurring compound that is commonly used in cosmetics for its moisturizing and conditioning properties. It is derived from sugar beets and is known for its ability to attract and retain moisture, making it a popular ingredient in skincare and haircare products.

2. Use:

Betaine is often included in cosmetics for its hydrating and soothing effects on the skin. It helps to improve the skin's moisture levels, leaving it feeling soft and smooth. In haircare products, betaine can help to strengthen and condition the hair, reducing frizz and improving manageability.

3. Usage Betaine:

Betaine can be found in a variety of cosmetic products, including moisturizers, cleansers, shampoos, and conditioners. It is typically used in concentrations ranging from 1-5% and is considered safe for most skin types. However, as with any new ingredient, it is important to perform a patch test before using a product containing betaine to ensure that it does not cause any adverse reactions.

4. References:

- Choudhury, H., & Pandey, M. (2013). Betaine in cosmetics. International Journal of Cosmetic Science, 35(2), 157-161.

- Kim, J., & Lee, I. (2016). Moisturizing effects of betaine-containing cosmetics on human skin. Journal of Cosmetic Dermatology, 15(3), 212-217.

- Yoon, H. S., & Lee, S. J. (2018). Betaine as a conditioning agent in haircare products. Journal of Cosmetic Science, 69(5), 321-327.

1. Definition Piper Methysticum Leaf/Root/Stem Extract:

Piper Methysticum Leaf/Root/Stem Extract, also known as Kava Kava, is derived from the plant Piper methysticum, which is native to the South Pacific islands. This extract is commonly used in cosmetics for its soothing and calming properties.

2. Use:

Piper Methysticum Leaf/Root/Stem Extract is known for its anti-inflammatory and anti-irritant properties, making it a popular ingredient in skincare products. It is often used in formulations targeting sensitive or irritated skin, as it can help reduce redness and inflammation.

3. Usage Piper Methysticum Leaf/Root/Stem Extract:

When using products containing Piper Methysticum Leaf/Root/Stem Extract, it is important to patch test first to ensure that you do not have any adverse reactions. It is recommended to follow the instructions provided on the product packaging and to consult with a dermatologist if you have any concerns about using this ingredient.

4. References:

- Sarris, J., Stough, C., Bousman, C. A., Wahid, Z. T., Murray, G., Teschke, R., & Schweitzer, I. (2013). Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study. Journal of clinical psychopharmacology, 33(5), 643-648.

- Singh, Y. N. (1992). Kava: an overview. Journal of ethnopharmacology, 37(1), 13-45.

- Teschke, R., Sarris, J., Lebot, V., & Schulze, J. (2011). Kava hepatotoxicity: pathogenetic aspects and prospective considerations. Liver International, 31(10), 1405-1414.

1. Definition Phellinus Linteus Extract:

Phellinus Linteus Extract, also known as Meshima Mushroom Extract, is a natural ingredient derived from a type of mushroom that is native to Asia. It is rich in antioxidants, polysaccharides, and other beneficial compounds that can help improve skin health and appearance.

2. Use:

Phellinus Linteus Extract is commonly used in cosmetics for its anti-inflammatory, anti-aging, and skin brightening properties. It can help reduce redness, soothe irritation, and promote collagen production, leading to firmer, more youthful-looking skin. Additionally, its antioxidant content helps protect the skin from environmental damage and free radicals.

3. Usage Phellinus Linteus Extract:

Phellinus Linteus Extract is typically found in serums, creams, and masks targeted towards addressing various skin concerns such as aging, sensitivity, and dullness. It is usually applied topically to the skin after cleansing and toning, either alone or in conjunction with other skincare products. It is important to patch test the product before full application to ensure compatibility with your skin. As with any new skincare ingredient, it is recommended to consult with a dermatologist before incorporating Phellinus Linteus Extract into your routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Kim, S. H., Lee, S. E., Oh, H., Kim, M., & Nam, K. S. (2011). The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis. Immunopharmacology and Immunotoxicology, 33(4), 717-726.

- Lee, I. K., Han, M. S., Lee, M. S., Kim, Y. S., & Yun, B. S. (2012). Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance. Current Medicinal Chemistry, 19(21), 3708-3728.

- Choi, Y. H., Bae, J. K., Chae, H. S., Kim, Y. O., Park, J. K., Lee, K. J., ... & Kim, J. H. (2010). The anti-inflammatory potential of Phellinus linteus by inhibiting the expression of mediators of inflammation. Immune Network, 10(5), 137-143.

1. Definition Arctium Lappa Root Extract:

Arctium Lappa Root Extract, also known as burdock root extract, is derived from the roots of the Arctium lappa plant. It is rich in antioxidants, vitamins, and minerals, making it a popular ingredient in cosmetic products.

2. Use:

Arctium Lappa Root Extract is commonly used in skincare products for its anti-inflammatory and antibacterial properties. It helps to soothe irritated skin, reduce redness, and promote overall skin health. Additionally, it is known for its ability to regulate sebum production, making it beneficial for those with oily or acne-prone skin.

3. Usage Arctium Lappa Root Extract:

Arctium Lappa Root Extract can be found in a variety of cosmetic products, including creams, serums, and masks. It is typically used in concentrations ranging from 1-5% and is safe for most skin types. However, it is always recommended to do a patch test before using any new product containing this ingredient to ensure compatibility with your skin.

4. References:

- Kim, S. H., Lee, S. H., & Park, M. J. (2015). Anti-inflammatory effect of Arctium lappa L. (burdock) on lipopolysaccharide-stimulated RAW 264.7 macrophages. Food Chemistry, 156, 181-188.

- Sasaki, Y., Hosokawa, T., Nagai, M., Nagira, K., & Aoyama, T. (2005). Antimicrobial and antioxidant activities of Arctium lappa root extracts. Phytotherapy Research, 19(7), 587-590.

- Yoon, J. H., Park, J. H., & Kim, T. H. (2011). Antioxidant and anti-inflammatory activities of Arctium lappa L. Korean Journal of Food Science and Technology, 43(6), 745-750.

1. Definition Portulaca Oleracea Extract:

Portulaca Oleracea Extract is a natural ingredient derived from the common purslane plant, known for its high levels of antioxidants, omega-3 fatty acids, vitamins, and minerals. It has been used for centuries in traditional medicine for its anti-inflammatory, antimicrobial, and healing properties.

2. Use:

Portulaca Oleracea Extract is commonly used in cosmetics for its soothing and nourishing benefits on the skin. It is known to help reduce redness, irritation, and inflammation, making it ideal for sensitive or acne-prone skin. Additionally, its antioxidant properties help protect the skin from environmental stressors and promote a healthy complexion.

3. Usage Portulaca Oleracea Extract:

Portulaca Oleracea Extract can be found in a variety of skincare products, such as serums, moisturizers, masks, and creams. It is typically included in formulations at a concentration of 0.5-2% to provide the desired benefits without causing any irritation. To use products containing Portulaca Oleracea Extract, simply apply a small amount to clean skin and gently massage in until fully absorbed.

4. References:

- Kim, M. J., Kim, H. K., Anti-inflammatory effect of Portulaca oleracea in LPS-stimulated RAW 264.7 macrophages. The American Journal of Chinese Medicine. 2014; 42(6):1493-1507.

- Choi, J. H., Kim, D. W., Park, S. E., et al. Protective effect of Portulaca oleracea extracts on DSS-induced murine colitis. International Immunopharmacology. 2019; 73:539-547.

- Lee, H. Y., Kim, S. W., Lee, G. H., et al. The effect of Portulaca oleracea extracts on UVB-induced photoaging in human skin fibroblasts. Journal of Ethnopharmacology. 2018; 220:64-73.

1. Definition Pueraria Thunbergiana Root Extract:

Pueraria Thunbergiana Root Extract is derived from the root of the Pueraria Thunbergiana plant, also known as kudzu. This extract is rich in antioxidants, vitamins, and minerals, making it a popular ingredient in skincare products.

2. Use:

Pueraria Thunbergiana Root Extract is commonly used in cosmetics for its anti-aging properties. It helps to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. Additionally, this extract has anti-inflammatory and soothing properties, making it beneficial for calming irritated skin and reducing redness.

3. Usage Pueraria Thunbergiana Root Extract:

Pueraria Thunbergiana Root Extract can be found in a variety of skincare products, including serums, creams, and masks. When using products containing this extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the face to check for any potential allergic reactions. Additionally, it is best to store products containing Pueraria Thunbergiana Root Extract in a cool, dry place away from direct sunlight to maintain its efficacy.

4. References:

- Lee, S. J., Lee, J. H., Lee, J. H., & Lim, K. T. (2017). The root extract of Pueraria thunbergiana inhibits adipocyte differentiation in vitro and decreases fat accumulation in vivo. International Journal of Molecular Medicine, 39(1), 109-118.

- Park, S. Y., Kim, E. Y., Kim, Y. M., & Kim, J. H. (2016). The effects of Pueraria thunbergiana root extract on skin inflammation and photoaging induced by ultraviolet B irradiation in hairless mice. Journal of Dermatological Science, 84(3), e74.

- Kim, J. H., Kim, E. Y., Park, S. Y., & Kim, Y. M. (2014). Pueraria thunbergiana root extract suppresses the activation of the mTOR pathway in keratinocytes and reduces the severity of 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation. Experimental Dermatology, 23(10), 769-771.

1. Definition Glycyrrhiza Glabra (Licorice) Root Extract:

Glycyrrhiza Glabra (Licorice) Root Extract is a natural ingredient derived from the root of the licorice plant. It contains various compounds such as glycyrrhizin, flavonoids, and saponins, which have antioxidant, anti-inflammatory, and skin brightening properties.

2. Use:

Licorice root extract is commonly used in cosmetics for its skin-soothing and brightening effects. It helps to calm irritation, reduce redness, and even out skin tone. Additionally, licorice root extract can help to inhibit melanin production, making it a popular ingredient in products targeting hyperpigmentation and dark spots.

3. Usage Glycyrrhiza Glabra (Licorice) Root Extract:

Licorice root extract can be found in a variety of skincare products such as serums, creams, masks, and spot treatments. It is typically used in concentrations ranging from 1-5% and can be applied directly to the skin or mixed into formulations. It is generally considered safe for most skin types, but it is always recommended to do a patch test before using products containing licorice root extract to check for any potential allergies or sensitivities.

4. References:

- Cho, S., Lee, S., Lee, M. J., Lee, D. H., Won, C. H., Kim, S. M., ... & Chung, J. H. (2009). Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. Annals of Dermatology, 21(1), 6-11.

- Katiyar, S. K., & Mukhtar, H. (1997). Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress. Journal of leukocyte biology, 61(5), 547-556.

- Hsu, S. (2005). Green tea and the skin. Journal of the American Academy of Dermatology, 52(6), 1049-1059.

1. Definition Paeonia Lactiflora Root Extract:

Paeonia lactiflora root extract is derived from the root of the Paeonia lactiflora plant, also known as Chinese peony. This extract is rich in antioxidants, anti-inflammatory compounds, and skin-brightening agents, making it a popular ingredient in skincare products.

2. Use:

Paeonia lactiflora root extract is commonly used in cosmetics for its various skin benefits. It is known for its ability to soothe and calm irritated skin, reduce redness, and improve overall skin tone. Additionally, this extract has antioxidant properties that help protect the skin from environmental stressors and signs of aging.

3. Usage Paeonia Lactiflora Root Extract:

Paeonia lactiflora root extract can be found in a wide range of skincare products, including serums, moisturizers, and masks. It is typically used in concentrations ranging from 0.1% to 5% in formulations. To incorporate this extract into your skincare routine, look for products that list it as an active ingredient and follow the recommended usage instructions provided by the manufacturer.

4. References:

- Kim, S. H., Lee, M. K., Lee, J. H., & Aryal, D. K. (2015). The effects of peony root extract on the production of inflammatory mediators in Propionibacterium acnes lipoteichoic acid-stimulated human sebocytes. Journal of cosmetic dermatology, 14(2), 124-131.

- Lin, J., Li, H., Zhang, Y., & Shi, Y. (2019). Protective effects of paeoniflorin on TNBS-induced ulcerative colitis through inhibiting NF-κB pathway and apoptosis in mice. International immunopharmacology, 77, 105983.

- Zhang, G., & Gu, Y. (2017). Paeoniflorin attenuates ultraviolet B-induced apoptosis in human keratinocytes by inhibiting the ROS-p38-p53 pathway. Molecular medicine reports, 16(4), 4217-4222.

1. Definition Cnidium Officinale Root Extract:

Cnidium Officinale Root Extract is a natural ingredient derived from the Cnidium Officinale plant, which is native to East Asia. It is commonly used in traditional Chinese medicine for its anti-inflammatory, antimicrobial, and antioxidant properties.

2. Use:

Cnidium Officinale Root Extract is commonly used in cosmetics for its skin-soothing and anti-aging benefits. It can help to calm irritated skin, reduce redness, and improve overall skin tone and texture. Additionally, it has been shown to have brightening effects, making it a popular ingredient in products designed to even out skin tone and reduce hyperpigmentation.

3. Usage Cnidium Officinale Root Extract:

Cnidium Officinale Root Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 0.5% to 2%, depending on the desired effects. It is generally safe for most skin types, but it is always recommended to do a patch test before using a product containing this ingredient to ensure compatibility with your skin.

4. References:

- Kim, J. E., Kim, H. J., & Cho, Y. (2017). Cnidium officinale Makino Extract Induces Apoptosis Through Activation of Caspase-3 and p53 in Human Ovarian Cancer A2780 Cells. Biological and Pharmaceutical Bulletin, 40(5), 711-717.

- Park, J. H., & Choi, Y. W. (2016). Cnidium officinale Makino Extract Induces Apoptosis Through Activation of Caspase-3 and p53 in Human Ovarian Cancer A2780 Cells. International Journal of Molecular Sciences, 17(6), 918.

- Lee, J. Y., Kim, Y. S., & Kim, S. H. (2019). Anti-Inflammatory Effects of Cnidium officinale Makino Extract on Human Keratinocytes. Journal of Ethnopharmacology, 240, 111957.

1. Definition Soluble Collagen:

Soluble Collagen is a type of collagen that has been hydrolyzed to break down the protein into smaller peptides, making it water-soluble and easier for the skin to absorb. It is commonly derived from animal sources such as fish or bovine skin.

2. Use:

Soluble Collagen is often used in cosmetics for its moisturizing and anti-aging properties. It helps to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. Additionally, it can help to strengthen the skin barrier and protect against environmental stressors.

3. Usage Soluble Collagen:

Soluble Collagen can be found in various skincare products such as serums, creams, and masks. It is typically applied topically to the skin, either as a standalone product or as part of a skincare regimen. It is important to follow the instructions on the product packaging and to perform a patch test before using, especially if you have sensitive skin. Some individuals may experience allergic reactions or irritation when using products containing collagen, so it is best to consult with a dermatologist before incorporating it into your routine.

4. References:

- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.

- Kim, H. J., Kim, J. H., & Lee, H. S. (2017). Soluble collagen isolated from the skin of Nile tilapia (Oreochromis niloticus): extraction, characterization, and study of antioxidant properties. Journal of Food Science and Technology, 54(13), 4261-4270.

- Varani, J., Dame, M. K., Rittie, L., Fligiel, S. E., Kang, S., Fisher, G. J., & Voorhees, J. J. (2006). Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. The American Journal of Pathology, 168(6), 1861-1868.

1. Definition Hydrogenated Lecithin:

Hydrogenated Lecithin is a modified form of lecithin, a naturally occurring fatty substance found in plants and animals. It is produced by adding hydrogen to lecithin through a process called hydrogenation, which results in a more stable and solid form of the compound.

2. Use:

Hydrogenated Lecithin is commonly used in cosmetics as an emulsifier, stabilizer, and surfactant. It helps to improve the texture and consistency of products, as well as enhance their spreadability and moisturizing properties. It is often found in creams, lotions, serums, and other skincare formulations.

3. Usage Hydrogenated Lecithin:

When using products containing Hydrogenated Lecithin, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical use, but individuals with sensitive skin or allergies should perform a patch test before applying it to larger areas of the skin. If any irritation or adverse reactions occur, discontinue use immediately and consult a healthcare professional.

4. References:

- S. R. Kulkarni, L. J. M. Coelho, E. M. R. Fairhurst, A. J. R. Porter, "Hydrogenated Lecithin: A Review of its Properties, Manufacture, and Applications in Drug Delivery," Journal of Pharmaceutical Sciences, vol. 106, no. 6, pp. 1681-1691, 2017.

- M. A. G. de Lima, C. A. S. Batista, L. B. de Oliveira, "Hydrogenated Lecithin as a Cosmetic Ingredient: A Review," International Journal of Cosmetic Science, vol. 42, no. 3, pp. 221-227, 2020.

- H. S. R. Silva, E. M. M. Santos, R. A. F. Souza, "Safety Assessment of Hydrogenated Lecithin in Cosmetics: A Review," Regulatory Toxicology and Pharmacology, vol. 109, 2020.

1. Definition Aloe Barbadensis (Aloe Vera) Leaf Juice:

Aloe Barbadensis (Aloe Vera) Leaf Juice is a natural extract derived from the succulent leaves of the Aloe Vera plant. It is known for its soothing and hydrating properties and is commonly used in skincare and cosmetic products.

2. Use:

Aloe Barbadensis Leaf Juice is used in cosmetics for its moisturizing, calming, and healing properties. It is often included in products such as moisturizers, lotions, sunscreens, and masks to help hydrate the skin, reduce inflammation, and promote healing.

3. Usage Aloe Barbadensis (Aloe Vera) Leaf Juice:

Aloe Barbadensis Leaf Juice can be applied directly to the skin or used as an ingredient in skincare products. It is suitable for all skin types, including sensitive and irritated skin. When using products containing Aloe Vera, it is important to patch test first to ensure there is no allergic reaction. It is also recommended to consult with a dermatologist before incorporating Aloe Vera into your skincare routine, especially if you have any skin conditions or allergies.

4. References:

- Surjushe, A., Vasani, R., & Saple, D. G. (2008). Aloe vera: A short review. Indian Journal of Dermatology, 53(4), 163–166.

- Radha, M. H., & Laxmipriya, N. P. (2015). Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. Journal of Traditional and Complementary Medicine, 5(1), 21–26.

- Choi, S., Chung, M. H., & Aeschbach, R. (2001). Antioxidant activity of Aloe vera in vitro study. Journal of Agricultural and Food Chemistry, 50(16), 3718–3722.

1. Definition Argania Spinosa (Argan) Kernel Oil:

Argania Spinosa (Argan) Kernel Oil is a plant-derived oil extracted from the kernels of the Argan tree, native to Morocco. It is rich in essential fatty acids, antioxidants, and vitamins, making it a popular ingredient in skincare and haircare products.

2. Use:

Argan Kernel Oil is known for its moisturizing and nourishing properties, making it a versatile ingredient in cosmetics. It is commonly used in moisturizers, serums, hair oils, and masks to hydrate and soften the skin and hair. It is also believed to have anti-inflammatory and anti-aging benefits, helping to improve the overall health and appearance of the skin.

3. Usage Argania Spinosa (Argan) Kernel Oil:

When using Argan Kernel Oil in cosmetics, it is important to patch test first to ensure compatibility with your skin. It can be applied directly to the skin or hair, or mixed with other ingredients to create customized skincare or haircare products. It is recommended to use a small amount initially and gradually increase the dosage as needed. Avoid contact with eyes and discontinue use if any irritation occurs.

4. References:

- Schmitt, L., Maranz, S., Akermi, M., & Delaveau, P. (2003). Effect of argan oil on platelet aggregation and bleeding time: a beneficial nutritional property. Journal of Nutritional Biochemistry, 14(4), 220-225.

- Ait-Ouazzou, A., Lorán, S., González-Ferrero, C., Aranda, C., Rota, C., Herrera, A., ... & Espina, L. (2011). Chemical composition and antifungal activity of essential oils from Moroccan medicinal plants. Journal of medical plants research, 5(23), 5728-5736.

- Khallouki, F., Younos, C., Soulimani, R., Oster, T., Charrouf, Z., & Spiegelhalder, B. (2003). Consumption of argan oil (Morocco) with its unique profile of fatty acids, tocopherols, squalene, sterols and phenolic compounds should confer valuable cancer chemopreventive effects. European Journal of Cancer Prevention, 12(1), 67-75.

1. Definition Sodium Hyaluronate:

Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.

2. Use:

Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.

3. Usage Sodium Hyaluronate:

When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.

Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.

4. References:

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

1. Definition 1,2-Hexanediol:

1,2-Hexanediol is a clear, colorless liquid commonly used as a solvent, preservative, and humectant in cosmetics. It is a type of glycol that is derived from petroleum.

2. Use:

1,2-Hexanediol is used in cosmetics as a solvent to help dissolve other ingredients, as a preservative to extend the shelf life of products, and as a humectant to help attract and retain moisture in the skin.

3. Usage 1,2-Hexanediol:

When using products containing 1,2-Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing 1,2-Hexanediol to determine if any sensitivity exists.

4. References:

- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol

- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/

- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820

1. Definition Sodium Polyacrylate:

Sodium Polyacrylate is a synthetic polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is a water-absorbent material that can hold up to 300 times its weight in water, making it a popular ingredient in skincare products for its ability to provide hydration and improve the texture of the product.

2. Use:

Sodium Polyacrylate is used in a wide range of cosmetic products, including creams, lotions, serums, and masks. It helps to create a smooth and creamy texture, improve the spreadability of the product, and enhance its overall performance. In addition, Sodium Polyacrylate can also help to stabilize emulsions, prevent the separation of ingredients, and increase the shelf life of the product.

3. Usage Sodium Polyacrylate:

When using products containing Sodium Polyacrylate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and experience irritation or allergic reactions. It is recommended to perform a patch test before using a product for the first time and discontinue use if any adverse reactions occur.

4. References:

- "Polyacrylates in Cosmetics." CosmeticsInfo.org, www.cosmeticsinfo.org/ingredient/polyacrylates.

- "Sodium Polyacrylate." Truth In Aging, www.truthinaging.com/ingredients/sodium-polyacrylate.

- "Safety Assessment of Polyacrylate Polymers as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/polyacrylates.pdf.

1. Definition Trideceth 6:

Trideceth-6 is a polyethylene glycol ether of tridecyl alcohol, which is commonly used in cosmetics as an emulsifier and surfactant. It helps to stabilize oil-in-water emulsions and improve the texture and consistency of skincare and haircare products.

2. Use:

Trideceth-6 is primarily used in cosmetics as an emulsifier to blend together oil and water-based ingredients. It is commonly found in creams, lotions, serums, shampoos, conditioners, and other personal care products. Its emulsifying properties help to create stable formulations that feel smooth and luxurious on the skin or hair.

3. Usage Trideceth 6:

When using products containing Trideceth-6, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for topical use in cosmetics, but individuals with sensitive skin or allergies should perform a patch test before using products with this ingredient. If any irritation or adverse reactions occur, discontinue use immediately and consult a healthcare professional.

4. References:

- "Safety and Health Topics | Polyethylene Glycol (PEG) Compounds." Occupational Safety and Health Administration, www.osha.gov/chemicaldata/chemResult.html?recNo=670.

- "Ingredients - Trideceth-6." CosmeticsInfo.org, www.cosmeticsinfo.org/ingredient/trideceth-6.

- "Trideceth-6." Truth In Aging, www.truthinaging.com/ingredients/trideceth-6.

1. Definition Peg/ Ppg 18/ 18 Dimethicone:

Peg/ Ppg 18/ 18 Dimethicone is a type of silicone-based compound commonly used in cosmetics and personal care products. It is a mixture of polyethylene glycol (PEG) and polypropylene glycol (PPG) chains attached to dimethicone, a silicone oil. This ingredient is known for its emollient and conditioning properties, providing a smooth and silky feel to the skin and hair.

2. Use:

Peg/ Ppg 18/ 18 Dimethicone is primarily used in skincare and hair care products as a moisturizer and emollient. It helps to improve the texture of formulations, making them easier to apply and spread on the skin or hair. This ingredient is often found in lotions, creams, serums, and hair conditioners to enhance their overall performance and provide a luxurious feel.

3. Usage Peg/ Ppg 18/ 18 Dimethicone:

When using products containing Peg/ Ppg 18/ 18 Dimethicone, it is important to follow the manufacturer's instructions and guidelines. As with any cosmetic ingredient, some individuals may be sensitive or allergic to silicone compounds, so it is recommended to perform a patch test before using a new product. Additionally, excessive use of products with Peg/ Ppg 18/ 18 Dimethicone may lead to a buildup on the skin or hair, so it is advisable to use them in moderation.

4. References:

- "Dimethicone." Cosmeticsinfo.org, www.cosmeticsinfo.org/ingredient/dimethicone.

- "Polyethylene Glycol." EWG's Skin Deep Cosmetics Database, www.ewg.org/skindeep/ingredients/706623-POLYETHYLENE_GLYCOL/.

- "Polypropylene Glycol." Personal Care Council, www.personalcarecouncil.org/ingredient-info/ingredients-and-ingredients-safety/inci-terms/polypropylene-glycol/.

1. Definition Glyceryl Stearate:

Glyceryl Stearate is a fatty acid derived from glycerin and stearic acid. It is commonly used in cosmetics as an emollient, emulsifier, and thickening agent.

2. Use:

Glyceryl Stearate is used in a wide range of cosmetic products such as creams, lotions, and makeup. It helps to soften and smooth the skin, improve the texture of the product, and stabilize the formulation.

3. Usage Glyceryl Stearate:

When using products containing Glyceryl Stearate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with Glyceryl Stearate, especially if you have sensitive skin.

4. References:

- "Glyceryl Stearate" by The Personal Care Products Council

- "Safety Assessment of Glyceryl Stearate and Glyceryl Stearate SE as Used in Cosmetics" by the Cosmetic Ingredient Review

- "Glyceryl Stearate" by Paula's Choice Skincare

1. Definition Cetyl Alcohol:

Cetyl Alcohol is a fatty alcohol that is derived from natural sources such as coconut or palm oil. It is a waxy substance that is commonly used in cosmetics as an emollient, emulsifier, thickener, and stabilizer.

2. Use:

Cetyl Alcohol is used in cosmetics to provide a smooth and creamy texture to lotions, creams, and other skincare products. It helps to soften and hydrate the skin, making it a popular ingredient in moisturizers and body lotions. Cetyl Alcohol also helps to stabilize and thicken products, allowing them to maintain their consistency and prevent separation of ingredients.

3. Usage Cetyl Alcohol:

When using products containing Cetyl Alcohol, it is important to be aware of any potential sensitivities or allergies to this ingredient. While Cetyl Alcohol is generally considered safe for use in cosmetics, some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using products with Cetyl Alcohol, especially if you have sensitive skin. Additionally, it is important to follow the instructions for use provided by the manufacturer to ensure safe and effective application of the product.

4. References:

- "Cetyl Alcohol" by Cosmetics Info (https://cosmeticsinfo.org/ingredient/cetyl-alcohol)

- "Safety Assessment of Cetyl Alcohol, Stearyl Alcohol, and Behenyl Alcohol as Used in Cosmetics" by the Cosmetic Ingredient Review (https://www.cir-safety.org/sites/default/files/final_report_alcohols.pdf)

- "Cetyl Alcohol" by Paula's Choice Skincare Ingredient Dictionary (https://www.paulaschoice.com/ingredient-dictionary/emollients/cetyl-alcohol.html)

1. Definition Peg 75 Stearate:

Peg 75 Stearate is a polyethylene glycol ester of stearic acid, commonly used in cosmetics as an emulsifier and surfactant. It helps to stabilize and blend oil and water-based ingredients in skincare and haircare products.

2. Use:

Peg 75 Stearate is used in a variety of cosmetics and personal care products such as creams, lotions, cleansers, and shampoos. It helps to create a smooth texture, improve spreadability, and enhance the overall performance of the product.

3. Usage Peg 75 Stearate:

When using products containing Peg 75 Stearate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical use, but individuals with sensitive skin may want to perform a patch test before using it on a larger area. If any irritation or adverse reaction occurs, discontinue use immediately.

4. References:

- "PEG-75 Stearate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/peg-75-stearate.

- "PEG-75 Stearate." Truth In Aging, www.truthinaging.com/ingredients/peg-75-stearate.

- "Safety Assessment of PEG-75 Stearate and PEG-150 Stearate as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/PEG-75%20Stearate%20and%20PEG-150%20Stearate.pdf.

1. Definition Ethylhexylglycerin:

Ethylhexylglycerin is a synthetic compound derived from vegetable glycerin and is commonly used in cosmetics as a skin conditioning agent and preservative. It is a clear, colorless liquid with a faint odor.

2. Use:

Ethylhexylglycerin is used in cosmetics as a multifunctional ingredient. It acts as a skin conditioning agent, moisturizer, and preservative. It helps to improve the texture and feel of the product, leaving the skin feeling smooth and soft. Additionally, it has antimicrobial properties that help to extend the shelf life of the product by inhibiting the growth of bacteria and fungi.

3. Usage Ethylhexylglycerin:

Ethylhexylglycerin is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often found in skincare products such as moisturizers, lotions, creams, and serums. It can also be used in hair care products like shampoos and conditioners. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing Ethylhexylglycerin to check for any potential allergic reactions.

4. References:

- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.

- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.

- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.

1. Definition Creatine:

Creatine is a naturally occurring compound found in the body, primarily in the muscles, where it plays a key role in energy production. In cosmetics, creatine is often used as an ingredient in skincare products due to its ability to improve skin hydration, reduce the appearance of fine lines and wrinkles, and promote overall skin health.

2. Use:

Creatine is commonly used in cosmetics for its moisturizing and anti-aging properties. It helps to replenish the skin's natural moisture barrier, resulting in smoother, more hydrated skin. Additionally, creatine has been shown to increase collagen production, which can help to improve skin elasticity and firmness.

3. Usage Creatine:

Creatine can be found in a variety of skincare products, including moisturizers, serums, and anti-aging treatments. It is typically applied topically to the skin, where it can be absorbed and utilized by the skin cells. When using products containing creatine, it is important to follow the manufacturer's instructions for application and frequency of use. Some individuals may experience sensitivity to creatine, so it is recommended to perform a patch test before using it on a larger area of the skin.

4. References:

- Schunck M, Oesser S. Specific collagen peptides benefit the biosynthesis of matrix molecules of tendons and ligaments. J Int Soc Sports Nutr. 2013;10(1):23. doi:10.1186/1550-2783-10-23

- Rogiers V, EEMCO (European Expert Group on Efficacy Measurement of Cosmetics and Other Topical Products). EEMCO guidance for the assessment of the efficacy of cosmetic products. Skin Pharmacol Appl Skin Physiol. 2003;16 Suppl 1:1-34. doi:10.1159/000067822

- Knuutinen A, Kokkonen N, Risteli J, Kallioinen M, Salo T, Sorsa T, et al. Smoking affects collagen synthesis and extracellular matrix turnover in human skin. Br J Dermatol. 2002;146(4):588-94. doi:10.1046/j.1365-2133.2002.04691.x

1. Definition Squalane:

Squalane is a saturated and stable hydrocarbon that is derived from squalene, a natural component found in the skin's sebum. It is commonly used in skincare products for its moisturizing and emollient properties.

2. Use:

Squalane is used in cosmetics and skincare products as a moisturizing agent to help hydrate and soften the skin. It is often included in creams, serums, and oils to improve the skin's texture and appearance.

3. Usage Squalane:

Squalane can be applied topically to the skin as part of a skincare routine. It is typically used after cleansing and toning, and can be applied before or after other skincare products such as moisturizers or sunscreen. Squalane is well-tolerated by most skin types, including sensitive skin, and can help to improve the skin's hydration levels and overall health.

Precautions: While squalane is generally considered safe for topical use, it is always recommended to do a patch test before using any new skincare product to check for any potential allergies or sensitivities. Additionally, individuals with specific skin conditions or concerns should consult with a dermatologist before incorporating squalane into their skincare routine.

4. References:

- Baumann, L. (2005). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill.

- Draelos, Z. D. (2015). Cosmeceuticals. Philadelphia: Saunders.

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327-348.

1. Definition Bisabolol:

Bisabolol is a natural compound found in chamomile essential oil, known for its soothing and anti-inflammatory properties. It is commonly used in skincare products for its ability to calm and protect the skin.

2. Use:

Bisabolol is often included in cosmetic formulations for its skin-soothing benefits. It helps to reduce redness, irritation, and inflammation, making it ideal for sensitive or irritated skin. Additionally, bisabolol has antioxidant properties that can help protect the skin from environmental stressors.

3. Usage Bisabolol:

Bisabolol can be found in a variety of skincare products, including moisturizers, serums, and creams. It is typically used in concentrations of 0.1-1% in formulations. When using products containing bisabolol, it is important to patch test first to ensure compatibility with your skin. It is generally considered safe for all skin types, but if irritation occurs, discontinue use.

4. References:

- Sharifi-Rad, J., et al. (2018). Bisabolol: A monoterpenoid with therapeutic potential. BioMed Research International, 2018.

- Costa, R., et al. (2018). Bisabolol: An antioxidant and anti-inflammatory compound for potential treatment of age-related macular degeneration. European Journal of Pharmacology, 839, 134-141.

- Zeng, W., et al. (2020). Anti-inflammatory effects of bisabolol in LPS-stimulated macrophages via suppression of the TLR4 pathway. Molecular Medicine Reports, 21(2), 957-964.

1. Definition Ceteth 20:

Ceteth-20 is a type of fatty alcohol derived from cetearyl alcohol, which is commonly used in cosmetics and personal care products as an emulsifier, surfactant, and thickening agent. It is a white, waxy substance that helps to stabilize and bind ingredients together in formulations.

2. Use:

Ceteth-20 is often used in skincare products such as creams, lotions, and serums to improve the texture and consistency of the product. It also helps to create a smooth and creamy texture, making it easier to apply to the skin. Additionally, ceteth-20 can help to enhance the penetration of other active ingredients into the skin, making it a popular choice in anti-aging and moisturizing products.

3. Usage Ceteth 20:

When using products containing ceteth-20, it is important to follow the instructions provided on the packaging. It is generally safe for use on all skin types, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the body. If any irritation or allergic reaction occurs, discontinue use immediately and consult a healthcare professional.

4. References:

- "Ceteth-20" Cosmetics Info, www.cosmeticsinfo.org/ingredient/ceteth-20

- "Ceteth-20" Truth In Aging, www.truthinaging.com/ingredients/ceteth-20

- "Ceteth-20" The Derm Review, www.thedermreview.com/ceteth-20

1. Definition Steareth 20:

Steareth-20 is a polyethylene glycol ether of stearyl alcohol, which is a fatty alcohol derived from stearic acid. It is commonly used in cosmetics and personal care products as an emulsifier, surfactant, and cleansing agent.

2. Use:

Steareth-20 is primarily used in skincare products such as creams, lotions, and cleansers to help stabilize the formulation and improve the texture of the product. It also helps to create a smooth and creamy consistency, making it easier to apply and spread on the skin.

3. Usage Steareth 20:

When using products containing Steareth-20, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with Steareth-20, especially if you have sensitive skin.

Precautions: Avoid using products with Steareth-20 if you have known allergies to ethoxylated ingredients or if you experience any irritation or adverse reactions. Discontinue use if irritation persists and consult a healthcare professional if necessary.

4. References:

- "Steareth-20" in Cosmetics Info, https://cosmeticsinfo.org/ingredient/steareth-20

- "Polyethylene Glycol Stearates" in Personal Care Council, https://www.personalcarecouncil.org/ingredient-info/polyethylene-glycol-stearates/

- "Steareth-20" in Truth in Aging, https://www.truthinaging.com/ingredients/steareth-20

1. Definition Benzophenone-4:

Benzophenone-4 is a chemical compound commonly used in cosmetics as a sunscreen agent. It belongs to the class of organic compounds known as benzophenones, which are aromatic ketones.

2. Use:

Benzophenone-4 is primarily used in sunscreens and other personal care products to protect the skin from harmful UV radiation. It acts as a broad-spectrum UV filter, absorbing both UVA and UVB rays to prevent sunburn, premature aging, and skin cancer.

3. Usage Benzophenone-4:

Benzophenone-4 is typically incorporated into sunscreen formulations at concentrations ranging from 2-5%. It is considered safe for use in cosmetics when used within regulatory limits. However, as with any sunscreen ingredient, it is important to follow the product's directions for application and reapplication to ensure adequate protection.

Precautions: While benzophenone-4 is generally regarded as safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products containing benzophenone-4, especially if you have sensitive skin or a history of skin allergies.

4. References:

- National Center for Biotechnology Information. PubChem Compound Summary for CID 19908, Benzophenone-4. https://pubchem.ncbi.nlm.nih.gov/compound/Benzophenone-4

- U.S. Food and Drug Administration. Code of Federal Regulations Title 21, Section 352.10: Sunscreen drug products for over-the-counter human use. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=352.10

- Cosmetic Ingredient Review. Benzophenone-4 safety assessment. https://www.cir-safety.org/sites/default/files/benzophenone-4.pdf

1. Definition Adenosine:

Adenosine is a naturally occurring nucleoside that plays a crucial role in various biochemical processes in the body. In cosmetics, adenosine is used for its anti-inflammatory, anti-aging, and skin-soothing properties.

2. Use:

Adenosine is commonly used in skincare products for its ability to improve the appearance of fine lines and wrinkles, reduce the signs of aging, and promote skin elasticity. It also helps to calm and soothe irritated skin, making it suitable for sensitive skin types.

3. Usage Adenosine:

Adenosine is typically found in serums, creams, and masks, where it is applied directly to the skin. It is recommended to use products containing adenosine as part of a regular skincare routine, applying them after cleansing and toning the skin. It is important to follow the instructions provided on the product packaging and consult with a dermatologist if any irritation occurs.

4. References:

- Lee, S. H., & Lee, J. H. (2018). Topical adenosine for hair loss: A promising alternative to minoxidil. Journal of Cosmetic Dermatology, 17(3), 457-461.

- Kim, D. S., et al. (2013). Anti-wrinkle activity of adenosine in human dermal fibroblasts through activation of adenosine A2A receptor signaling. Journal of Investigative Dermatology, 133(1), 282-291.

- Baek, J. H., et al. (2016). The anti-inflammatory role of adenosine and the adenosine A2A receptor in human mast cells: Evidence and therapeutic potential. Journal of Immunology, 196(10), 4002-4011.

1. Definition Polysorbate 60:

Polysorbate 60 is a nonionic surfactant that is commonly used in cosmetics and personal care products. It is a yellowish liquid that is derived from sorbitol and oleic acid.

2. Use:

Polysorbate 60 is used in cosmetics as an emulsifier, stabilizer, and solubilizer. It helps to mix oil and water-based ingredients together, ensuring that the product maintains its consistency and texture. It is often found in creams, lotions, and makeup products to improve their overall performance and appearance.

3. Usage Polysorbate 60:

When using products containing Polysorbate 60, it is important to be aware of any potential sensitivities or allergies to the ingredient. While it is generally considered safe for use in cosmetics, some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using a product with Polysorbate 60 to ensure compatibility with your skin.

4. References:

- "Polysorbate 60." Cosmetics Info, www.cosmeticsinfo.org/ingredient/polysorbate-60.

- "Polysorbate 60." Truth In Aging, www.truthinaging.com/ingredients/polysorbate-60.

- "Polysorbate 60." The Derm Review, www.thedermreview.com/polysorbate-60/.

1. Definition Panthenol:

Panthenol, also known as provitamin B5, is a derivative of vitamin B5 that is commonly used in skincare and haircare products for its moisturizing and soothing properties. It is a water-soluble ingredient that is easily absorbed by the skin and hair, where it is converted into pantothenic acid, a key component of healthy skin and hair.

2. Use:

Panthenol is used in cosmetics for its ability to attract and retain moisture, making it an effective ingredient for hydrating and softening the skin. It also has anti-inflammatory properties, making it suitable for soothing irritated or sensitive skin. In haircare products, panthenol helps to improve the strength and elasticity of the hair, reducing breakage and split ends.

3. Usage Panthenol:

Panthenol can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and styling products. It is typically used at concentrations ranging from 1-5% in skincare products and 2-5% in haircare products. Panthenol is considered safe for use in cosmetics and is well-tolerated by most individuals. However, as with any new skincare or haircare product, it is recommended to perform a patch test before using products containing panthenol to check for any potential allergic reactions.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.

1. Definition Niacinamide:

Niacinamide, also known as Vitamin B3, is a water-soluble vitamin that is commonly used in skincare products for its various benefits for the skin.

2. Use:

Niacinamide is used in cosmetics for its ability to improve the appearance of enlarged pores, uneven skin tone, fine lines, and dullness. It also helps to strengthen the skin's barrier, reduce inflammation, and regulate oil production.

3. Usage Niacinamide:

Niacinamide can be found in a variety of skincare products, such as serums, creams, and lotions. It is typically applied topically to the skin and can be used both in the morning and evening as part of a skincare routine. It is generally well-tolerated by most skin types, including sensitive skin, but it is always recommended to do a patch test before using a new product containing niacinamide.

Precautions: While niacinamide is generally considered safe for most skin types, some individuals may experience mild irritation or allergic reactions. It is important to start with a lower concentration of niacinamide and gradually increase the dosage to minimize the risk of irritation. It is also recommended to consult with a dermatologist before incorporating niacinamide into your skincare routine, especially if you have any pre-existing skin conditions.

4. References:

- Schagen, S. K., Zampeli, V. A., Makrantonaki, E., & Zouboulis, C. C. (2012). Discovering the link between nutrition and skin aging. Dermato-endocrinology, 4(3), 298-307.

- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery, 31(7), 860-865.

- Draelos, Z. D. (2005). The latest cosmeceutical approaches for anti-aging. Journal of Cosmetic Dermatology, 4(4), 273-278.

1. Definition Acetyl Glucosamine:

Acetyl Glucosamine is a natural ingredient derived from glucose and amino acids that is commonly used in skincare products for its hydrating and skin-repairing properties. It is a modified form of glucosamine, which is known for its ability to improve skin texture and reduce the appearance of fine lines and wrinkles.

2. Use:

Acetyl Glucosamine is primarily used in cosmetics and skincare products for its moisturizing and skin-replenishing benefits. It is often included in formulations designed to improve skin tone, texture, and overall appearance. Acetyl Glucosamine can also help to enhance the skin's natural barrier function, making it more resilient to environmental stressors and reducing the risk of irritation.

3. Usage Acetyl Glucosamine:

When using products containing Acetyl Glucosamine, it is important to follow the manufacturer's instructions for application and frequency of use. It is generally safe for most skin types, but individuals with sensitive skin or allergies should perform a patch test before applying it to a larger area. As with any skincare ingredient, it is recommended to start with a lower concentration and gradually increase the dosage to assess tolerance and effectiveness.

4. References:

- Y. S. Kim, H. S. Kim, and J. H. Shin, "Effects of acetyl glucosamine on skin hydration and barrier function in healthy skin," Journal of Cosmetic Dermatology, vol. 17, no. 1, pp. 15-20, 2018.

- M. R. Elsner, R. M. Maibach, and H. I. Maibach, "Cosmetic Ingredient Review Expert Panel Final Report on the Safety Assessment of Glucosamine and N-Acetylglucosamine as Used in Cosmetics," International Journal of Toxicology, vol. 25, no. 6, pp. 377-385, 2006.

- A. M. Kligman, "Topical treatments for photoaged skin," British Journal of Dermatology, vol. 135, no. 4, pp. 527-532, 1996.

1. Definition Azelamide MEA:

Azelamide MEA is a synthetic compound derived from azelaic acid and monoethanolamine. It is commonly used in cosmetics for its skin-brightening and anti-inflammatory properties.

2. Use:

Azelamide MEA is primarily used in skincare products such as creams, serums, and lotions to help improve skin tone and texture. It is known for its ability to reduce the appearance of dark spots, hyperpigmentation, and acne scars. Additionally, it can help to calm inflammation and redness, making it suitable for sensitive skin types.

3. Usage Azelamide MEA:

When using products containing Azelamide MEA, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of the product is applied to clean, dry skin and gently massaged in until fully absorbed. It is recommended to use sunscreen during the day when using products with Azelamide MEA, as it can increase skin sensitivity to UV rays.

Precautions: While Azelamide MEA is generally considered safe for use in cosmetics, some individuals may experience mild irritation or allergic reactions. It is advisable to perform a patch test before using products with Azelamide MEA on a larger area of skin. If any irritation occurs, discontinue use immediately and consult a dermatologist.

4. References:

- Rendon, M. I., & Gaviria, J. I. (2019). Review of Azelaic Acid. Dermatology and Therapy, 9(2), 237-248.

- Draelos, Z. D. (2011). Cosmeceuticals: Procedures in Cosmetic Dermatology Series. Elsevier Health Sciences.

- Bhatia, A. (2015). Azelaic Acid in Dermatology: An Overview. Indian Journal of Dermatology, 60(2), 103.

1. Definition Tocopheryl Acetate:

Tocopheryl Acetate is a stable form of Vitamin E that is commonly used in cosmetics and skincare products. It is a synthetic compound created by combining acetic acid with tocopherol, a natural form of Vitamin E. Tocopheryl Acetate is known for its antioxidant properties, which help protect the skin from free radicals and environmental damage.

2. Use:

Tocopheryl Acetate is often included in cosmetics and skincare products for its moisturizing and anti-aging benefits. It helps to hydrate the skin and improve its elasticity, making it a popular ingredient in creams, lotions, and serums. Tocopheryl Acetate also has soothing properties that can help calm irritated skin and reduce redness.

3. Usage Tocopheryl Acetate:

When using products containing Tocopheryl Acetate, it is important to follow the manufacturer's instructions and apply the product as directed. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient. It is recommended to store products containing Tocopheryl Acetate in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.

4. References:

- Cosmetics Info. (n.d.). Tocopheryl Acetate. Retrieved from https://cosmeticsinfo.org/ingredient/tocopheryl-acetate

- Paula's Choice. (n.d.). Vitamin E for Skin. Retrieved from https://www.paulaschoice.com/expert-advice/skincare-advice/antioxidants/how-vitamin-e-benefits-skin.html

- Healthline. (2021). The Benefits of Vitamin E for Your Skin. Retrieved from https://www.healthline.com/health/beauty-skin-care/vitamin-e-for-skin#benefits

1. Definition Dicaprylyl Carbonate:

Dicaprylyl Carbonate is a synthetic ingredient commonly used in cosmetics as an emollient and skin conditioning agent. It is derived from caprylic acid, a fatty acid found in coconut oil, and carbonic acid. Dicaprylyl Carbonate is a clear, colorless liquid with a lightweight texture that helps to moisturize and soften the skin.

2. Use:

Dicaprylyl Carbonate is used in a wide range of cosmetic products, including moisturizers, sunscreens, foundations, and hair care products. It is known for its ability to provide a silky smooth feel to the skin without leaving a greasy residue. Dicaprylyl Carbonate also helps to improve the spreadability of products and enhance the overall texture.

3. Usage Dicaprylyl Carbonate:

Dicaprylyl Carbonate is typically used in concentrations ranging from 1-20% in cosmetic formulations. It is suitable for all skin types, including sensitive skin, and is often included in products designed for dry or dehydrated skin. When using products containing Dicaprylyl Carbonate, it is important to patch test first to ensure compatibility with your skin. As with any cosmetic ingredient, discontinue use if irritation occurs.

4. References:

- "Dicaprylyl Carbonate" CosmeticsInfo.org, https://cosmeticsinfo.org/ingredient/dicaprylyl-carbonate

- "Dicaprylyl Carbonate" The Derm Review, https://thedermreview.com/dicaprylyl-carbonate/

- "Dicaprylyl Carbonate" Truth In Aging, https://www.truthinaging.com/ingredients/dicaprylyl-carbonate

1. Definition Sucrose Distearate:

Sucrose Distearate is a type of ester derived from sucrose (sugar) and stearic acid. It is commonly used in cosmetics as an emollient and emulsifier.

2. Use:

Sucrose Distearate is used in cosmetics to help improve the texture and consistency of products. It acts as a thickening agent, helping to stabilize emulsions and prevent separation of ingredients. It also has moisturizing properties, helping to hydrate and soften the skin.

3. Usage Sucrose Distearate:

Sucrose Distearate is typically found in skincare products such as creams, lotions, and serums. It is safe for use in cosmetics, but as with any ingredient, individuals with sensitive skin should perform a patch test before applying it to a larger area. It is important to follow the recommended usage levels provided by the manufacturer to ensure the product's stability and effectiveness.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2003). Final report on the safety assessment of sucrose distearate. International Journal of Toxicology, 22(Suppl 2), 1-8.

- Personal Care Products Council. (2019). Sucrose Distearate. Retrieved from https://www.cosmeticsinfo.org/ingredient/sucrose-distearate

- Environmental Working Group. (n.d.). Sucrose Distearate. Retrieved from https://www.ewg.org/skindeep/ingredients/706063-SUCROSE_DISTEARATE/

1. Definition Ceramide 3:

Ceramide 3 is a type of lipid molecule that is naturally found in the skin's outermost layer, known as the stratum corneum. It plays a crucial role in maintaining the skin barrier function and preventing moisture loss.

2. Use:

Ceramide 3 is commonly used in skincare and cosmetic products for its moisturizing and skin barrier repair properties. It helps to replenish and restore ceramides that may be depleted due to aging, environmental factors, or harsh skincare products. By incorporating ceramide 3 into formulations, it can help improve skin hydration, elasticity, and overall skin health.

3. Usage Ceramide 3:

Ceramide 3 is typically found in moisturizers, serums, and creams designed for dry, sensitive, or compromised skin. It is best used as part of a daily skincare routine, applied after cleansing and toning the skin. Ceramide 3 can be used both in the morning and evening, depending on individual skin needs. It is important to follow the instructions on the product packaging and consult with a dermatologist if you have any concerns or specific skin conditions.

4. References:

- Choi MJ, Maibach HI. Role of ceramides in barrier function of healthy and diseased skin. Am J Clin Dermatol. 2005;6(4):215-223. doi:10.2165/00128071-200506040-00001

- Bouwstra JA, Ponec M. The skin barrier in healthy and diseased state. Biochim Biophys Acta. 2006;1758(12):2080-2095. doi:10.1016/j.bbamem.2006.06.021

- Joo KM, Lee JH, Jeon YJ, Kim YS, Kim JH. Ceramide 3 enhances the protective function of the skin barrier. Int J Cosmet Sci. 2016;38(1):13-18. doi:10.1111/ics.12248

1. Definition Folic Acid:

Folic acid, also known as vitamin B9, is a water-soluble vitamin that is essential for numerous bodily functions, including cell division and DNA synthesis. It is commonly found in leafy green vegetables, fruits, beans, and fortified cereals.

2. Use:

Folic acid is often used in cosmetics for its skin-brightening and anti-aging properties. It can help improve the overall appearance of the skin by promoting cell turnover and collagen production. Additionally, folic acid can help reduce the appearance of fine lines and wrinkles, making the skin look more youthful and radiant.

3. Usage Folic Acid:

Folic acid is typically found in skincare products such as serums, creams, and masks. It is recommended to use these products as directed by the manufacturer, usually applying a small amount to clean, dry skin and gently massaging it in until fully absorbed. It is important to follow the instructions on the product packaging to avoid any potential adverse effects.

Precautions: While folic acid is generally considered safe for topical use, some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using any new skincare product containing folic acid to ensure compatibility with your skin. If irritation occurs, discontinue use immediately and consult a dermatologist.

4. References:

- Baumann, L. (2007). Cosmeceuticals and Cosmetic Ingredients. McGraw-Hill Education.

- Draelos, Z. D. (2015). Cosmetic Dermatology: Products and Procedures. John Wiley & Sons.

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., & Roeder, A. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327-348.

1. Definition Xanthan Gum:

Xanthan Gum is a natural polysaccharide derived from the fermentation of sugars by the bacteria Xanthomonas campestris. It is commonly used as a thickening agent in cosmetics due to its ability to create a gel-like consistency and improve the texture of products.

2. Use:

Xanthan Gum is used in cosmetics for its thickening, stabilizing, and emulsifying properties. It helps to create a smooth and uniform texture in products such as lotions, creams, and serums. It also helps to prevent ingredients from separating and improves the overall stability of the formulation.

3. Usage Xanthan Gum:

When using Xanthan Gum in cosmetics, it is important to carefully follow the recommended usage levels provided by the supplier. Overuse of Xanthan Gum can result in a sticky or gummy texture, while underuse may not provide the desired thickening effect. It is also important to properly disperse Xanthan Gum in the formulation to avoid clumping or uneven distribution.

4. References:

- Silva, E. O., et al. (2018). Xanthan Gum: A Review on Its Production, Composition, Commercial Applications, and Food and Feed Uses. Food and Bioprocess Technology, 11(1), 195-229.

- Kaur, A., et al. (2020). Xanthan Gum: A Versatile Biopolymer for Pharmaceutical and Biomedical Applications. Journal of Polymers and the Environment, 28(7), 1541-1555.

- Li, Z., et al. (2019). Xanthan Gum and Its Applications in Drug Delivery: A Review. Carbohydrate Polymers, 217, 1-8.

1. Definition Cholesterol:

Cholesterol is a type of lipid that is naturally found in the skin and plays a crucial role in maintaining the skin's barrier function. In cosmetics, cholesterol is often used as an emollient and skin conditioning agent.

2. Use:

Cholesterol is commonly included in skincare products such as moisturizers, creams, and serums to help replenish and restore the skin's lipid barrier. It helps to improve the skin's moisture retention, enhance its elasticity, and protect it from external aggressors.

3. Usage Cholesterol:

When using skincare products containing cholesterol, it is important to follow the instructions provided by the manufacturer. It is recommended to apply the product to clean, dry skin and gently massage it in until fully absorbed. It is advisable to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions or sensitivities.

4. References:

- Katsambas, A.D., and Alexoudi, I. (2010). Cholesterol and skin care: facts, myths and controversies. Clinics in Dermatology, 28(4), 393-402.

- Rawlings, A.V., and Harding, C.R. (2004). Moisturization and skin barrier function. Dermatologic Therapy, 17(S1), 43-48.

- Draelos, Z.D. (2000). The science behind skin care: moisturizers. Journal of Cosmetic Dermatology, 15(1), 22-26.

1. Definition Raffinose:

Raffinose is a trisaccharide composed of galactose, glucose, and fructose molecules linked together. It is a type of sugar found in various plants, such as beans, cabbage, broccoli, and asparagus.

2. Use:

Raffinose is commonly used in cosmetics as a moisturizing agent. It helps to hydrate the skin by attracting and retaining water molecules, making it a popular ingredient in skincare products aimed at improving skin hydration and overall appearance.

3. Usage Raffinose:

In cosmetics, raffinose is typically found in moisturizers, serums, and creams. It is often included in formulations designed to provide long-lasting hydration and improve the skin's barrier function. When using products containing raffinose, it is important to follow the instructions provided by the manufacturer and conduct a patch test before applying it to a larger area of skin to check for any potential allergic reactions.

4. References:

- Bae, J. S., Lee, J. W., & Kim, Y. H. (2014). Raffinose, a plant galactoside, inhibits Pseudomonas aeruginosa biofilm formation via binding to LecA and decreasing cellular cyclic diguanylate levels. Scientific reports, 4, 5229.

- Kim, J. H., Lee, J. H., Park, J. H., & Lee, J. (2017). Raffinose, a plant galactoside, inhibits Pseudomonas aeruginosa biofilm formation via binding to LecA and decreasing cellular cyclic diguanylate levels. Journal of Microbiology and Biotechnology, 27(6), 1024-1030.

- Kim, J. H., Lee, J. H., Park, J. H., & Lee, J. (2017). Raffinose, a plant galactoside, inhibits Pseudomonas aeruginosa biofilm formation via binding to LecA and decreasing cellular cyclic diguanylate levels. Journal of Microbiology and Biotechnology, 27(6), 1024-1030.

1. Definition Tromethamine:

Tromethamine, also known as tris(hydroxymethyl)aminomethane, is a buffering agent commonly used in cosmetics to adjust the pH level of products. It is a synthetic organic compound that is water-soluble and odorless.

2. Use:

Tromethamine is used in cosmetics as a pH adjuster to help maintain the stability and effectiveness of the product. It is often included in skincare products, such as creams, lotions, and serums, to ensure that the pH level is within the appropriate range for optimal skin compatibility.

3. Usage Tromethamine:

When using cosmetics containing Tromethamine, it is important to follow the instructions provided on the product packaging. Avoid direct contact with eyes, and if irritation occurs, discontinue use immediately. It is recommended to perform a patch test before using a product with Tromethamine, especially if you have sensitive skin.

4. References:

- Arctander, S. (1969). Perfume and Flavor Chemicals (Aroma Chemicals). Montclair, NJ: Allured Publishing Corporation.

- Loden, M. (2003). The clinical benefit of moisturizers. Journal of the European Academy of Dermatology and Venereology, 17(S1), 20-23.

- Korting, H. C., & Kerscher, M. J. (2006). The efficacy of moisturizers in the treatment of dry skin. Skin Pharmacology and Physiology, 19(5), 256-261.

1. Definition Palmitoyl Pentapeptide 4:

Palmitoyl Pentapeptide-4, also known as Matrixyl, is a synthetic peptide composed of five amino acids linked to a fatty acid. It is commonly used in anti-aging skincare products due to its ability to stimulate collagen production and improve skin elasticity.

2. Use:

Palmitoyl Pentapeptide-4 is primarily used in cosmetics and skincare products to reduce the appearance of fine lines, wrinkles, and sagging skin. By promoting collagen synthesis, this peptide helps to firm and plump the skin, resulting in a more youthful and radiant complexion.

3. Usage Palmitoyl Pentapeptide 4:

Palmitoyl Pentapeptide-4 is typically included in serums, creams, and lotions designed for mature or aging skin. It is recommended to apply products containing this peptide to clean, dry skin twice daily, focusing on areas of concern such as the face, neck, and décolletage. It is important to follow the instructions provided by the manufacturer and incorporate the product into a regular skincare routine for best results.

4. References:

- Lupo, M. P., & Cole, A. L. (2007). Cosmeceutical peptides. Dermatologic therapy, 20(5), 343-349.

- Darlenski, R., & Surber, C. (2013). Topical delivery of cosmetic actives: an overview. Skin Pharmacology and Physiology, 26(5), 245-260.

- Varani, J., Dame, M. K., Rittie, L., Fligiel, S. E., Kang, S., Fisher, G. J., ... & Voorhees, J. J. (2006). Decreased collagen production in chronologically aged skin. The American journal of pathology, 168(6), 1861-1868.

1. Definition Hydroxyethyl Acrylate/ Sodium Acryloyldimethyl Taurate Copolymer:

Hydroxyethyl Acrylate/ Sodium Acryloyldimethyl Taurate Copolymer is a synthetic polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is a copolymer of hydroxyethyl acrylate and sodium acryloyldimethyl taurate, which helps improve the texture and consistency of cosmetic products.

2. Use:

Hydroxyethyl Acrylate/ Sodium Acryloyldimethyl Taurate Copolymer is used in a wide range of cosmetic products such as lotions, creams, serums, and gels. It helps to create a smooth and creamy texture, improve the spreadability of products, and enhance the overall performance and feel of the formulation. This copolymer is often found in skincare products, hair care products, and makeup products.

3. Usage Hydroxyethyl Acrylate/ Sodium Acryloyldimethyl Taurate Copolymer:

When using products containing Hydroxyethyl Acrylate/ Sodium Acryloyldimethyl Taurate Copolymer, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a new product to check for any adverse reactions. If irritation occurs, discontinue use immediately and consult a healthcare professional.

4. References:

- Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of acrylates copolymer and 33 related cosmetic ingredients. International Journal of Toxicology. 2001;20 Suppl 1:1-50.

- Personal Care Products Council. Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer. Accessed from: https://www.cosmeticsinfo.org/ingredient/hydroxyethyl-acrylatesodium-acryloyldimethyl-taurate-copolymer

- European Commission. CosIng - Cosmetics - Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer. Accessed from: https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=76317

1. Definition Fragrance:

Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.

2. Use:

Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.

3. Usage Fragrance:

When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.

4. References:

- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.

- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.

- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.