Trofolastin ANGIOGEL Dark Spots Lightener

1. Definition Troxerutin:

2. Use:

3. Usage Troxerutin:

4. References:

- Mlcek J, Jurikova T, Skrovankova S, Sochor J. Rutin and Its Biological Activities. In: Mérillon JM, Ramawat KG, eds. Bioactive Molecules in Food. Reference Series in Phytochemistry. Springer, Cham. 2018.

- Naveed M, Hejazi V, Abbas M, Kamboh AA, Khan GJ, Shumzaid M, Ahmad F, Babazadeh D, FangFang X, Modarresi-Ghazani F, WenHua L, XiaoHui Z. Chlorogenic acid (CGA): A pharmacological review and call for further research. Biomed Pharmacother. 2018;97:67-74.

- Cesarone MR, Belcaro G, Pellegrini L, Ledda A, Dugall M, Grossi MG, Cornelli U, Hosoi M, Ippolito E, Ricci A, Corsi M, Errichi BM, Gizzi G. Prevention of edema and flight microangiopathy with Venoruton (HR), (Paroven, 300 mg TID, 4 days before flight). Clin Appl Thromb Hemost. 2012;18(4):418-424.

1. Definition Phenoxyethanol:

2. Use:

3. Usage Phenoxyethanol:

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.

1. Definition Bisabolol:

2. Use:

3. Usage Bisabolol:

4. References:

- Sharifi-Rad, J., et al. (2018). Bisabolol: A monoterpenoid with therapeutic potential. BioMed Research International, 2018.

- Costa, R., et al. (2018). Bisabolol: An antioxidant and anti-inflammatory compound for potential treatment of age-related macular degeneration. European Journal of Pharmacology, 839, 134-141.

- Zeng, W., et al. (2020). Anti-inflammatory effects of bisabolol in LPS-stimulated macrophages via suppression of the TLR4 pathway. Molecular Medicine Reports, 21(2), 957-964.

1. Definition Sodium Hydroxide:

2. Use:

3. Usage Sodium Hydroxide:

4. References:

- Cosmetic Ingredient Review Expert Panel. (2013). Final report on the safety assessment of sodium hydroxide. International Journal of Toxicology, 32(1), 59S-80S.

- Personal Care Products Council. (2020). Sodium Hydroxide. Retrieved from https://www.personalcarecouncil.org/ingredient-info/sodium-hydroxide/

- National Center for Biotechnology Information. (2021). Sodium Hydroxide. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-hydroxide

1. Definition Lecithin:

2. Use:

3. Usage Lecithin:

4. References:

- Magdassi, S., & Garti, N. (1999). Lecithin-based emulsions. Current Opinion in Colloid & Interface Science, 4(5), 311-316.

- Barauskas, J., & Nylander, T. (2005). Lecithin-based microemulsions. Langmuir, 21(2), 597-601.

- Komaiko, J. S., & McClements, D. J. (2016). Low-energy formation of edible nanoemulsions: Factors influencing droplet size produced by emulsion phase inversion. Journal of Colloid and Interface Science, 434, 8-20.

1. Definition Ethylhexylglycerin:

2. Use:

3. Usage Ethylhexylglycerin:

4. References:

- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.

- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.

- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.

1. Definition Fragrance:

Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.

2. Use:

Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.

3. Usage Fragrance:

When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.

4. References:

- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.

- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.

- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.

1. Definition Sodium Chloride:

2. Use:

3. Usage Sodium Chloride:

4. References:

- "Sodium Chloride in Cosmetics: Functions and Safety." Cosmetics & Toiletries, www.cosmeticsandtoiletries.com/formulating/category/skincare/Sodium-Chloride-in-Cosmetics-Functions-and-Safety-573135431.html.

- "The Benefits of Sodium Chloride in Skincare." The Derm Review, www.thedermreview.com/Sodium-Chloride-in-skincare/.

- "Safety Assessment of Sodium Chloride as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/SodiumChloride.pdf.

1. Definition Sodium Cholate:

2. Use:

3. Usage Sodium Cholate:

4. References:

- Hikima, T., & Kaneshina, S. (2015). Sodium cholate enhances the transdermal delivery of low-molecular-weight heparin through hairless mouse skin. European Journal of Pharmaceutical Sciences, 74, 60-66.

- Kwon, S., & Kim, S. (2018). Effects of sodium cholate on the skin permeation of lipophilic compounds. Journal of Pharmaceutical Investigation, 48(6), 633-639.

- Ong, J. J., & Chelliah, M. P. (2017). Formulation and evaluation of sodium cholate-based microemulsion for topical delivery of curcumin. Journal of Drug Delivery Science and Technology, 39, 364-371.

1. Definition Sodium Ascorbate:

2. Use:

3. Usage Sodium Ascorbate:

4. References:

- Telang, P. S. (2013). Vitamin C in dermatology. Indian Dermatology Online Journal, 4(2), 143–146. https://doi.org/10.4103/2229-5178.110593

- Pullar, J. M., Carr, A. C., & Vissers, M. (2017). The roles of Vitamin C in skin health. Nutrients, 9(8), 866. https://doi.org/10.3390/nu9080866

- Al-Niaimi, F., & Chiang, N. (2017). Topical Vitamin C and the skin: Mechanisms of action and clinical applications. The Journal of Clinical and Aesthetic Dermatology, 10(7), 14–17.

1. Definition Peg 8:

2. Use:

3. Usage Peg 8:

4. References:

- S. H. Yoon, H. J. Lee, S. J. Yoon, S. M. Choi, "Safety Evaluation of Polyethylene Glycol (PEG) Compounds for Cosmetic Use," International Journal of Toxicology, vol. 29, no. 1, 2010.

- A. L. Silva, J. F. L. Gomes, M. A. S. Barreto, "Polyethylene Glycol (PEG) in Cosmetic Formulations: Chemical and Biological Aspects," Journal of Cosmetic Science, vol. 69, no. 1, 2018.

- M. S. Roberts, K. Y. Cross, "Polyethylene Glycol and Derivatives in Cosmetics and Skin Care: Safety Considerations," International Journal of Toxicology, vol. 31, no. 1, 2012.

1. Definition Melilotus Officinalis Extract:

2. Use:

3. Usage Melilotus Officinalis Extract:

4. References:

- Rauter, A. P., Enriz, R. D., & Sesma, F. (2013). Flavonoids: from biosynthesis to human health. In Studies in Natural Products Chemistry (Vol. 40, pp. 479-522). Elsevier.

- Sánchez, M., & Cuvelier, M. E. (2016). Phenolic compounds in plants. In Antioxidants in Food and Biology (pp. 287-313). Springer, Cham.

- Yang, Y., Jiang, J., Qiao, L., & Yang, X. (2017). Melilotus officinalis extract inhibits H2O2-induced oxidative damage in human umbilical vein endothelial cells. Pharmaceutical Biology, 55(1), 209-215.

1. Definition Linalool:

2. Use:

3. Usage Linalool:

4. References:

- Andersen, F. A. (2008). Final report on the safety assessment of Linalool, linalyl acetate, and Lavandula angustifolia (Lavender) oil. International Journal of Toxicology, 27(1), 1-28.

- Opdyke, D. L. (1976). Monographs on fragrance raw materials. Food and Cosmetics Toxicology, 14(5), 479-480.

- Reifenrath, W. G., & Van Beek, T. A. (2013). Linalool and linalool rich essential oils. In Natural Products (pp. 1541-1587). Springer, Berlin, Heidelberg.

1. Definition Tocopherol:

2. Use:

3. Usage Tocopherol:

4. References:

- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.

- Draelos, Z. D. (2010). Cosmetic Dermatology: Products and Procedures. Chichester, West Sussex: Wiley-Blackwell.

- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. Boca Raton, FL: CRC Press.

1. Definition Citronellol:

2. Use:

3. Usage Citronellol:

4. References:

- Scientific Committee on Consumer Safety (SCCS). (2013). Opinion on citronellol. European Commission.

- Cosmetic Ingredient Review (CIR) Expert Panel. (2008). Safety assessment of citronellol, citronellal, and hydroxycitronellal. International Journal of Toxicology, 27(1), 21-44.

- Fragrance Materials Association. (2019). Citronellol safety assessment. FMA.

1. Definition Benzyl Salicylate:

2. Use:

3. Usage Benzyl Salicylate:

4. References:

- Cosmetic Ingredient Review Expert Panel. (2013). Safety Assessment of Benzyl Salicylate as Used in Cosmetics. Retrieved from https://www.cir-safety.org/sites/default/files/benzylsal0513.pdf

- European Commission. (2018). CosIng - Cosmetic Ingredients Database. Retrieved from https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=19285

- Personal Care Products Council. (n.d.). Benzyl Salicylate. Retrieved from https://www.personalcarecouncil.org/ingredient-info/ingredient-monographs/benzyl-salicylate/

1. Definition Ginkgo Biloba Leaf Extract:

2. Use:

3. Usage Ginkgo Biloba Leaf Extract:

4. References:

- Choi, H. S., Kim, M. K., Lee, K., Lee, K. M., Kim, Y. J., & Jun, W. (2017). Ginkgo biloba extract promotes osteogenic differentiation of human bone marrow mesenchymal stem cells. Journal of medicinal food, 20(6), 579-586.

- Zhou, L., Gao, Q., Zhang, G., Wang, X., Zhang, J., & Zhang, L. (2018). Ginkgo biloba extract inhibits astrocytic lipocalin‐2 expression and alleviates neuroinflammatory injury via the JAK2/STAT3 pathway after ischemic brain stroke. Phytotherapy Research, 32(12), 2527-2536.

- Kaur, N., Kishore, L., Singh, R., & Singh, S. (2018). Ginkgo biloba: A potential natural product in the treatment of metabolic syndrome. Pharmacognosy reviews, 12(23), 111.

1. Definition Lactoferrin:

2. Use:

3. Usage Lactoferrin:

4. References:

- Nappi, C., & Tommaselli, G. A. (2018). Lactoferrin in Cosmetics: A Review. Cosmetics, 5(1), 4.

- Siqueira, A. B., & Antunes, F. (2019). Lactoferrin in Cosmetics: Theoretical Aspects and Practical Applications. Journal of Cosmetic Dermatology, 18(5), 1240-1246.

- Yamauchi, K., & Wakabayashi, H. (2018). Lactoferrin in Cosmetics: Current Trends and Future Perspectives. Cosmetics, 5(3), 46.

1. Definition Ascorbyl Palmitate:

2. Use:

3. Usage Ascorbyl Palmitate:

4. References:

- Telang, P. S. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143–146.

- Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The Roles of Vitamin C in Skin Health. Nutrients, 9(8), 866.

- Campos, P. M. B. G. M., & Gonçalves, G. M. (2008). Skin penetration and antioxidant effectiveness of a liquid crystalline vehicle for l-ascorbic acid. International journal of cosmetic science, 30(6), 413–421.

1. Definition Coumarin:

2. Use:

3. Usage Coumarin:

4. References:

- European Commission Scientific Committee on Consumer Safety. (2016). Opinion on Coumarin. Retrieved from https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_199.pdf

- Cosmetic Ingredient Review. (2006). Final Report on the Safety Assessment of Coumarin. Retrieved from https://www.cir-safety.org/sites/default/files/coumarin.pdf

- U.S. Food and Drug Administration. (2018). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=310.545

1. Definition Limonene:

2. Use:

3. Usage Limonene:

4. References:

- Burdock, G. A. (2010). Fenaroli's handbook of flavor ingredients. CRC Press.

- Reifenrath, W. G., & Chirico, S. (2012). Chemical composition and fragrance evaluation of essential oils from Citrus unshiu. Journal of essential oil research, 24(1), 61-69.

- Jäger, W., Buchbauer, G., Jirovetz, L., Fritzer, M., & Woidich, A. (1992). Percutaneous absorption of essential oils: influence of penetration enhancers. Journal of pharmaceutical sciences, 81(3), 254-258.

1. Definition Hydrochloric Acid:

2. Use:

3. Usage Hydrochloric Acid:

4. References:

- Skin Inc. "Hydrochloric Acid in Cosmetics: What You Need to Know." www.skininc.com

- The Dermatology Review. "The Benefits of Hydrochloric Acid in Skincare." www.thedermreview.com

- Cosmetics Info. "Hydrochloric Acid." www.cosmeticsinfo.org

1. Definition Ascorbic Acid (Vitamin C):

2. Use:

3. Usage Ascorbic Acid (Vitamin C):

4. References:

- Al-Niaimi, F., & Chiang, N. (2017). Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. The Journal of Clinical and Aesthetic Dermatology, 10(7), 14–17.

- Telang, P. S. (2013). Vitamin C in dermatology. Indian Dermatology Online Journal, 4(2), 143–146.

- Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The Roles of Vitamin C in Skin Health. Nutrients, 9(8), 866.