Valeant Pharmaceuticals International, Inc. Atralin® (tretinoin) gel 0.05%

1. Definition Carbomer 940:

Carbomer 940 is a synthetic polymer used in cosmetics as a thickening agent and emulsifier. It is a white, fluffy powder that swells in water to form a gel-like consistency.

2. Use:

Carbomer 940 is commonly used in skincare products such as lotions, creams, and gels to provide a smooth and thick texture. It helps to stabilize emulsions, improve product consistency, and enhance the spreadability of the product on the skin.

3. Usage Carbomer 940:

When using Carbomer 940 in cosmetics, it is important to follow the recommended usage guidelines provided by the manufacturer. Typically, it is added to the water phase of the formulation and mixed thoroughly to ensure proper dispersion. Overuse of Carbomer 940 can result in a sticky or tacky texture, so it is essential to measure and add the correct amount based on the formulation requirements.

Precautions: It is recommended to wear gloves and protective eyewear when handling Carbomer 940 in its powdered form to avoid irritation or allergic reactions. In case of skin or eye contact, rinse thoroughly with water and seek medical attention if irritation persists. It is also important to store Carbomer 940 in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.

4. References:

- P. D. Coates, M. J. Betts, in Cosmetics Additives, 1995.

- M. A. O'Lenick, in Surfactants in Cosmetics, 2006.

- B. M. Lawrence, in Cosmetics, 1995.

1. Definition Ethylparaben:

Ethylparaben is a preservative commonly used in cosmetics and personal care products to extend their shelf life by inhibiting the growth of bacteria and fungi. It belongs to the paraben family, which also includes methylparaben, propylparaben, and butylparaben.

2. Use:

Ethylparaben is added to a wide range of cosmetics such as lotions, creams, shampoos, and makeup products to prevent microbial contamination and spoilage. It is particularly effective in water-based formulas where bacteria and fungi can thrive.

3. Usage Ethylparaben:

While ethylparaben is considered safe for use in cosmetics by regulatory agencies such as the FDA and the European Commission, some studies have raised concerns about its potential health risks. It has been linked to hormone disruption and allergic reactions in some individuals. Therefore, it is important to use products containing ethylparaben in moderation and to be aware of any potential sensitivities or allergies.

4. References:

- SCCS (Scientific Committee on Consumer Safety). (2005). Opinion on Parabens. European Commission.

- Darbre, P. D., & Harvey, P. W. (2008). Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks. Journal of Applied Toxicology, 28(5), 561-578.

- FDA (U.S. Food and Drug Administration). (2019). Parabens in Cosmetics. U.S. Department of Health and Human Services.

1. Definition Hydrolyzed Collagen:

Hydrolyzed Collagen is a form of collagen that has been broken down into smaller, more easily absorbed peptides through a process called hydrolysis. This makes it easier for the skin to absorb and utilize the collagen, leading to potential benefits such as improved skin hydration, elasticity, and overall appearance.

2. Use:

Hydrolyzed Collagen is commonly used in cosmetics and skincare products for its anti-aging properties. It is often found in moisturizers, serums, and masks to help improve skin firmness, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. Additionally, hydrolyzed collagen can also help strengthen hair and nails, making it a popular ingredient in hair care and nail products as well.

3. Usage Hydrolyzed Collagen:

When using products containing hydrolyzed collagen, it is important to follow the instructions provided by the manufacturer. Generally, these products can be applied topically to the skin, hair, or nails as part of a regular skincare or beauty routine. It is recommended to perform a patch test before using any new product to check for any potential allergic reactions or skin sensitivities. Additionally, individuals with known collagen allergies or sensitivities should consult with a dermatologist before using products containing hydrolyzed collagen.

4. References:

- Choi, F.D., Sung, C.T., Juhasz, M.L., & Mesinkovsk, N.A. (2019). Oral Collagen Supplementation: A Systematic Review of Dermatological Applications. Journal of Drugs in Dermatology, 18(1), 9-16.

- Asserin, J., Lati, E., Shioya, T., & Prawitt, J. (2015). The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, 14(4), 291-301.

- Bolke, L., Schlippe, G., Gerß, J., & Voss, W. (2019). A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study. Nutrients, 11(10), 2494.

1. Definition Glycerin:

Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.

2. Use:

Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.

3. Usage Glycerin:

When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.

1. Definition Isobutylparaben:

Isobutylparaben is a type of paraben, which is a preservative commonly used in cosmetics and personal care products to prevent the growth of bacteria, mold, and yeast. Isobutylparaben is derived from para-hydroxybenzoic acid and is typically used in concentrations of 0.3% to 0.8% in cosmetic formulations.

2. Use:

Isobutylparaben is primarily used as a preservative in cosmetics such as lotions, creams, makeup, and hair care products. It helps to extend the shelf life of these products by inhibiting the growth of microorganisms, which can cause spoilage and degradation. By preventing microbial contamination, isobutylparaben helps to maintain the safety and efficacy of cosmetic products.

3. Usage Isobutylparaben:

When using cosmetics containing isobutylparaben, it is important to follow the manufacturer's instructions and guidelines for application. It is recommended to perform a patch test before using a new product to check for any potential allergic reactions or sensitivities to the preservative. Additionally, individuals with sensitive skin or skin conditions may want to avoid products containing isobutylparaben to prevent any potential irritation or adverse reactions.

4. References:

- SCCS (Scientific Committee on Consumer Safety). (2011). Opinion on Parabens. European Commission.

- Cosmetic Ingredient Review. (2006). Final Report on the Safety Assessment of Methylparaben, Ethylparaben, Propylparaben, and Butylparaben. International Journal of Toxicology, 25(1), 1-82.

- National Institute of Environmental Health Sciences. (2020). Parabens. U.S. Department of Health and Human Services.

1. Definition Methylparaben:

Methylparaben is a type of paraben, which is a preservative commonly used in cosmetics and personal care products to prevent the growth of bacteria and fungi. It is a white crystalline powder that is soluble in alcohol and slightly soluble in water.

2. Use:

Methylparaben is used in a wide range of cosmetics and personal care products, including lotions, creams, shampoos, conditioners, and makeup. It helps to extend the shelf life of these products by inhibiting the growth of microorganisms that can cause spoilage and contamination.

3. Usage Methylparaben:

Methylparaben is typically used at concentrations of 0.1% to 0.5% in cosmetics and personal care products. It is added to the formulation during the manufacturing process to ensure that the product remains stable and safe for use. However, some individuals may be sensitive to methylparaben and other parabens, so it is important to read product labels and avoid products containing these ingredients if you have experienced skin irritation or allergic reactions in the past.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2008). Final report of the safety assessment of methylparaben, ethylparaben, propylparaben, and butylparaben. International Journal of Toxicology, 27(4), 1-82.

- SCCS (Scientific Committee on Consumer Safety). (2011). Opinion on parabens. European Commission, Health & Consumers Directorate-General.

- Soni, M. G., Carabin, I. G., & Burdock, G. A. (2005). Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food and Chemical Toxicology, 43(7), 985-1015.

1. Definition Octoxynol 9:

Octoxynol 9 is a nonionic surfactant that is commonly used in cosmetics and personal care products. It is also known by its chemical name, Polyoxyethylene (9) Octylphenyl Ether, and is often used as an emulsifier and cleansing agent in various skincare and haircare products.

2. Use:

Octoxynol 9 is primarily used in cosmetics as a surfactant, which means it helps to lower the surface tension between two substances, allowing them to mix more easily. In skincare products, it can help to emulsify oils and water-based ingredients, creating a stable and uniform formulation. It is also used in cleansing products, such as shampoos and body washes, to help remove dirt, oil, and impurities from the skin and hair.

3. Usage Octoxynol 9:

When using products containing Octoxynol 9, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics when used in accordance with regulations and recommended concentrations. However, as with any ingredient, some individuals may be sensitive or allergic to Octoxynol 9, so it is advisable to perform a patch test before using a new product. Additionally, it is recommended to avoid contact with the eyes and to rinse thoroughly with water if contact occurs.

4. References:

- Chemical Safety Facts. (n.d.). Octoxynol. https://www.chemicalsafetyfacts.org/octoxynol/

- Cosmeticsinfo.org. (n.d.). Octoxynol-9. https://cosmeticsinfo.org/ingredient/octoxynol-9

- Personal Care Council. (2019). Octoxynol 9. https://www.personalcarecouncil.org/ingredient/octoxynol-9/

1. Definition Phenoxyethanol:

Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.

2. Use:

Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.

3. Usage Phenoxyethanol:

When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.

1. Definition Propylparaben:

Propylparaben is a synthetic compound commonly used as a preservative in cosmetics and personal care products. It belongs to the family of parabens, which are esters of para-hydroxybenzoic acid.

2. Use:

Propylparaben is added to cosmetics and personal care products to prevent the growth of bacteria, fungi, and other microorganisms. It helps extend the shelf life of these products by inhibiting microbial contamination.

3. Usage Propylparaben:

Propylparaben is typically used in concentrations ranging from 0.01% to 0.3% in cosmetics. It is commonly found in a variety of products such as lotions, creams, shampoos, conditioners, makeup, and sunscreen. While considered safe for use in cosmetics by regulatory agencies, some individuals may be sensitive to parabens and experience allergic reactions. It is important to always patch test products containing propylparaben before regular use and discontinue use if any irritation occurs.

4. References:

- Soni MG, Carabin IG, Burdock GA. Safety assessment of propyl paraben: a review of the published literature. Food Chem Toxicol. 2005;43(7):985-1015. doi:10.1016/j.fct.2005.01.020

- Cosmetic Ingredient Review. Final report on the safety assessment of propylparaben. Int J Toxicol. 2008;27 Suppl 4:1-82. doi:10.1080/10915810802548359

- SCCS (Scientific Committee on Consumer Safety). Opinion on parabens. European Commission. 2011.

1. Definition Mineral Water:

Mineral water in cosmetics refers to water sourced from natural mineral springs that contains various minerals and trace elements beneficial for the skin.

2. Use:

Mineral water is commonly used in cosmetics as a hydrating and refreshing ingredient. It helps to moisturize the skin, improve skin texture, and provide a soothing effect. Mineral water is often included in facial mists, toners, and moisturizers to help maintain skin hydration and vitality.

3. Usage Mineral Water:

Mineral water can be used in various ways in skincare routines. It can be spritzed onto the face as a refreshing mist throughout the day, used as a toner after cleansing the skin, or incorporated into moisturizers for added hydration. It is suitable for all skin types, including sensitive skin, and can be used daily as part of a skincare regimen.

4. References:

- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.

- Baumann, L. (2009). Cosmetic dermatology: principles and practice. McGraw-Hill Medical.

- Loden, M., & Maibach, H. I. (2012). Dry skin and moisturizers: chemistry and function. CRC Press.

1. Definition Sodium Hyaluronate:

Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.

2. Use:

Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.

3. Usage Sodium Hyaluronate:

When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.

Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.

4. References:

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.