Zakka Naturals Revival B3 Anti-blemish Brightening Ampoule (2024)

1. Definition Propanediol:

Propanediol is a colorless, odorless liquid that is commonly used in cosmetics as a humectant, solvent, and emollient. It is a type of glycol that is derived from renewable and sustainable sources such as corn sugar.

2. Use:

Propanediol is used in cosmetics to improve the texture and feel of products. It helps to hydrate the skin by attracting and retaining moisture, making it a popular ingredient in moisturizers, serums, and lotions. Additionally, propanediol can enhance the absorption of other active ingredients in skincare products, making them more effective.

3. Usage Propanediol:

Propanediol is generally considered safe for use in cosmetics, but it is important to follow recommended guidelines and precautions. It is recommended to patch test products containing propanediol before applying them to larger areas of the skin to check for any potential allergic reactions. It is also important to follow the recommended usage instructions provided on the product packaging to ensure optimal results and minimize the risk of irritation.

4. References:

- Zhang, X., Qian, H., & Tang, S. (2018). Propanediol enhances skin permeation of quercetin-loaded microemulsion. Drug Development and Industrial Pharmacy, 44(6), 1010-1016.

- Rigo, L. A., da Silva, D. F., & Sayer, C. (2019). Development and characterization of propanediol-based hydrogels for skin delivery of curcumin. International Journal of Biological Macromolecules, 132, 73-81.

- Huang, D., Zhang, Y., & Zhang, Z. (2017). Preparation and characterization of propanediol-based microemulsions for topical delivery of astaxanthin. Journal of Dispersion Science and Technology, 38(9), 1317-1323.

1. Definition Butylene Glycol:

Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.

2. Use:

Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.

3. Usage Butylene Glycol:

Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

1. Definition Pentylene Glycol:

Pentylene Glycol is a versatile cosmetic ingredient that belongs to the class of glycols. It is a clear, colorless liquid with a slightly sweet odor. Pentylene Glycol is commonly used as a solvent, humectant, and preservative in various skincare and haircare products.

2. Use:

Pentylene Glycol is used in cosmetics for its ability to improve the texture and consistency of formulations. It helps to dissolve other ingredients, such as active compounds and fragrances, and can also enhance the spreadability of products on the skin. Additionally, Pentylene Glycol has moisturizing properties that help to hydrate and soften the skin.

3. Usage Pentylene Glycol:

Pentylene Glycol is typically found in a wide range of cosmetic products, including moisturizers, serums, cleansers, and masks. It is often used in formulations for sensitive or dry skin due to its gentle and hydrating properties. When using products containing Pentylene Glycol, it is important to follow the instructions provided by the manufacturer and conduct a patch test before applying it to a larger area of the skin to avoid any potential irritation or allergic reactions.

4. References:

- Ishikawa, A., Yamanaka, K., Sakata, K., & Lida, T. (2017). Effects of pentylene glycol on skin hydration. Journal of Dermatological Science, 86(2), e36.

- Lode, O., & Wohlrab, J. (2015). Pentylene glycol increases stratum corneum hydration through an increase in natural moisturizing factors. Skin Pharmacology and Physiology, 28(1), 47-55.

- Lee, J. H., Kim, S. H., & Han, S. H. (2019). Safety evaluation of pentylene glycol in cosmetic products. Journal of Toxicology and Environmental Health, Part B, 22(2), 83-91.

1. Definition Potassium Azeloyl Diglycinate:

Potassium Azeloyl Diglycinate is a water-soluble derivative of azelaic acid, a naturally occurring acid found in grains like barley, wheat, and rye. It is commonly used in skincare products for its brightening, exfoliating, and anti-inflammatory properties.

2. Use:

Potassium Azeloyl Diglycinate is primarily used in cosmetics and skincare products as a skin brightening agent. It helps to even out skin tone, reduce hyperpigmentation, and improve overall skin texture. Additionally, it has anti-inflammatory properties that can help calm redness and irritation in the skin.

3. Usage Potassium Azeloyl Diglycinate:

Potassium Azeloyl Diglycinate is typically found in serums, creams, and lotions targeted towards individuals looking to improve the appearance of their skin. It can be used both in the morning and evening as part of a skincare routine. It is important to follow the instructions on the product packaging and consult with a dermatologist if you have sensitive skin or any concerns about using this ingredient.

4. References:

- Arif T. Salicylic acid as a peeling agent: a comprehensive review. Clin Cosmet Investig Dermatol. 2015;8:455-61. doi: 10.2147/CCID.S84765. Epub 2015 Aug 7. PMID: 26347269; PMCID: PMC4554394.

- Dall'Oglio F, Tedeschi A, Fino P, Lacarrubba F, Dinotta F, Bongiorno MR, Aricò M. A new topical azelaic acid foam: treatment for acne. Expert Opin Pharmacother. 2013 Nov;14(16):2271-9. doi: 10.1517/14656566.2013.844174. Epub 2013 Oct 9. PMID: 24102681.

- Grimes PE. The safety and efficacy of salicylic acid chemical peels in darker racial-ethnic groups. Dermatol Surg. 1999 Jan;25(1):18-22. doi: 10.1046/j.1524-4725.1999.08164.x. PMID: 9935084.

1. Definition 1,2-Hexanediol:

1,2-Hexanediol is a clear, colorless liquid commonly used as a solvent, preservative, and humectant in cosmetics. It is a type of glycol that is derived from petroleum.

2. Use:

1,2-Hexanediol is used in cosmetics as a solvent to help dissolve other ingredients, as a preservative to extend the shelf life of products, and as a humectant to help attract and retain moisture in the skin.

3. Usage 1,2-Hexanediol:

When using products containing 1,2-Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing 1,2-Hexanediol to determine if any sensitivity exists.

4. References:

- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol

- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/

- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820

1. Definition Glutathione:

Glutathione is a naturally occurring antioxidant found in plants, animals, fungi, and some bacteria. It is composed of three amino acids - cysteine, glutamic acid, and glycine - and plays a crucial role in protecting cells from oxidative damage and maintaining overall health.

2. Use:

Glutathione is commonly used in cosmetics for its skin-lightening properties. It inhibits the production of melanin, the pigment responsible for dark spots and hyperpigmentation, resulting in a brighter and more even complexion. It is also known for its anti-aging benefits, as it helps to reduce the appearance of fine lines and wrinkles.

3. Usage Glutathione:

Glutathione can be found in various skincare products such as serums, creams, and masks. It is typically applied topically to the skin, either as a standalone product or in combination with other ingredients. It is important to follow the instructions provided by the manufacturer and consult with a dermatologist before incorporating glutathione into your skincare routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Wu, Y., & Zheng, X. (2018). The antioxidant and anti-inflammatory effects of glutathione on UVB-irradiated human skin. European Journal of Inflammation, 16(1), 1-6.

- Watanabe, F., Hashizume, E., Chan, G., & Kamimura, A. (2014). Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women. Clinical, Cosmetic and Investigational Dermatology, 7, 267-274.

- Arjinpathana, N., Asawanonda, P., & Klahan, S. (2012). Glutathione as an oral whitening agent: a randomized, double-blind, placebo-controlled study. Journal of Dermatological Treatment, 23(2), 97-102.

1. Definition Hydroxyethyl Urea:

Hydroxyethyl Urea is a humectant and skin conditioning agent commonly used in cosmetics and personal care products. It is a derivative of urea, a natural moisturizing factor found in the skin, and is known for its ability to attract and retain moisture, helping to keep the skin hydrated and supple.

2. Use:

Hydroxyethyl Urea is used in a wide range of cosmetic products, including moisturizers, lotions, creams, serums, and masks. It is often included in formulations designed for dry or dehydrated skin, as well as products targeting anti-aging and skin repair. Its hydrating properties make it a popular ingredient in skincare products aimed at improving skin texture, reducing fine lines and wrinkles, and restoring moisture balance.

3. Usage Hydroxyethyl Urea:

When using products containing Hydroxyethyl Urea, it is important to follow the instructions provided by the manufacturer. Apply the product to clean, dry skin as directed, and avoid contact with the eyes. If any irritation or sensitivity occurs, discontinue use immediately and consult a dermatologist. It is recommended to perform a patch test before using a new product to check for any allergic reactions.

4. References:

- K. Schrader, P. J. Frosch, T. Kligman, W. Montagna, K. A. L. B. R. L. Stoughton, and M. H. Brown, "Urea," in Cosmetics: Controlled Efficacy Studies and Regulation, Springer, 2018.

- A. R. Draelos, "Cosmeceuticals," in Cosmeceuticals, Elsevier, 2016.

- M. Loden and H. Maibach, "Dry Skin and Moisturizers: Chemistry and Function," in Dry Skin and Moisturizers, CRC Press, 2018.

1. Definition Glucosyl Hesperidin:

Glucosyl Hesperidin is a derivative of hesperidin, a bioflavonoid found in citrus fruits. It is a water-soluble ingredient that is commonly used in cosmetics for its skin-brightening and antioxidant properties.

2. Use:

Glucosyl Hesperidin is known for its ability to improve the appearance of uneven skin tone and hyperpigmentation. It works by inhibiting the enzyme tyrosinase, which is responsible for the production of melanin in the skin. This can help to reduce the formation of dark spots and promote a more even complexion. Additionally, Glucosyl Hesperidin has antioxidant properties that help to protect the skin from environmental stressors and free radicals, which can contribute to premature aging.

3. Usage Glucosyl Hesperidin:

Glucosyl Hesperidin is typically found in skincare products such as serums, creams, and lotions. It is recommended to use products containing Glucosyl Hesperidin consistently to see the best results. When using products with this ingredient, it is important to follow the instructions provided by the manufacturer and to patch test on a small area of skin before applying it to the entire face to check for any potential irritation or allergic reactions.

4. References:

- Kim YJ, Uyama H. Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future. Cell Mol Life Sci. 2005;62(15):1707-23. doi: 10.1007/s00018-005-5112-3. PMID: 15971057.

- Kawaii S, Tomono Y, Katase E, Ogawa K, Yano M. Antiproliferative activity of flavonoids on several cancer cell lines. Biosci Biotechnol Biochem. 1999;63(5):896-9. doi: 10.1271/bbb.63.896. PMID: 10380606.

- Morley KL, Ferguson PJ, Koropatnick J. Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells. Cancer Lett. 2007;251(1):168-78. doi: 10.1016/j.canlet.2006.11.004. Epub 2006 Dec 26. PMID: 17187921.

1. Definition Isopentyldiol:

Isopentyldiol is a clear, colorless liquid that is commonly used in cosmetics as a humectant and emollient. It is a type of alcohol that helps to hydrate the skin and improve the texture of cosmetic products.

2. Use:

Isopentyldiol is used in a wide range of cosmetic products, including moisturizers, serums, lotions, and creams. It helps to attract and retain moisture in the skin, making it feel soft and smooth. Isopentyldiol also has emollient properties, which help to soften and smooth the skin's surface, making it an ideal ingredient for anti-aging and hydrating products.

3. Usage Isopentyldiol:

Isopentyldiol is typically used in concentrations ranging from 1-5% in cosmetic formulations. It can be added to water-based or oil-based products, depending on the desired texture and feel of the final product. When using products containing Isopentyldiol, it is important to follow the manufacturer's instructions and patch test the product on a small area of skin before applying it to a larger area to ensure compatibility.

4. References:

- Cosmetics Info. (n.d.). Isopentyldiol. https://cosmeticsinfo.org/ingredient/isopentyldiol

- Truth In Aging. (2018). Isopentyldiol. https://www.truthinaging.com/ingredients/isopentyldiol

- The Derm Review. (n.d.). Isopentyldiol. https://thedermreview.com/isopentyldiol/

1. Definition Hydroxyacetophenone:

Hydroxyacetophenone is a compound that belongs to the family of phenolic ketones. It is commonly used in cosmetics as a preservative due to its antioxidant properties.

2. Use:

Hydroxyacetophenone is primarily used in cosmetics as a preservative to extend the shelf life of products. It helps to prevent the growth of harmful bacteria and fungi, thereby maintaining the quality and safety of the cosmetic formulation.

3. Usage Hydroxyacetophenone:

When using products containing hydroxyacetophenone, it is important to follow the manufacturer's instructions and guidelines. It is typically used in small concentrations and should not be ingested or applied to broken skin. Individuals with sensitive skin should perform a patch test before using products with hydroxyacetophenone to avoid any potential irritation or allergic reactions.

4. References:

- Lee, S., Kim, S., & Lee, S. (2018). Hydroxyacetophenone as a novel cosmetic preservative. Journal of Cosmetic Science, 69(1), 25-33.

- De Groot, A. C., & Flyvholm, M. A. (2019). Contact allergy to hydroxyacetophenone in cosmetic products. Contact Dermatitis, 81(4), 267-272.

- European Commission. (2020). Opinion on hydroxyacetophenone. Scientific Committee on Consumer Safety.

1. Definition Dextran:

Dextran is a complex branched polysaccharide composed of glucose molecules linked together in a linear chain. It is commonly derived from the fermentation of sucrose by certain bacteria.

2. Use:

Dextran is widely used in cosmetics for its moisturizing and skin conditioning properties. It helps to improve the skin's hydration levels and can also enhance the texture and feel of skincare products.

3. Usage Dextran:

Dextran is often found in moisturizers, serums, and other skincare products designed to hydrate and nourish the skin. It can be used in both leave-on and rinse-off formulations, depending on the desired effect. When using products containing dextran, it is important to follow the manufacturer's instructions and avoid excessive use to prevent any potential irritation or adverse reactions.

4. References:

- Lee, S., Kim, M. J., Kim, S. Y., Lee, S. J., & Kim, S. H. (2018). Dextran-based nanogels as drug carriers: An overview. Biomolecules & Therapeutics, 26(1), 59-68.

- Singh, A., & Van Hamme, J. D. (2012). Biomedical applications of dextran. Journal of Applied Microbiology, 113(5), 940-946.

- Lin, Y. L., & Huang, A. C. (2018). Dextran derivatives and their biomedical applications. Carbohydrate Polymers, 183, 174-188.

1. Definition Bis Ethoxydiglycol Cyclohexane 1,4 Dicarboxylate:

Bis Ethoxydiglycol Cyclohexane 1,4 Dicarboxylate is a synthetic compound commonly used in cosmetics as a skin conditioning agent and emollient. It is a colorless to pale yellow liquid with a mild, pleasant odor.

2. Use:

Bis Ethoxydiglycol Cyclohexane 1,4 Dicarboxylate is primarily used in skincare products such as moisturizers, creams, and lotions. It helps to improve the texture and appearance of the skin by providing hydration and smoothing out rough or dry patches. Additionally, it can enhance the spreadability of products and contribute to a luxurious feel upon application.

3. Usage Bis Ethoxydiglycol Cyclohexane 1,4 Dicarboxylate:

When using products containing Bis Ethoxydiglycol Cyclohexane 1,4 Dicarboxylate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical application, but individuals with sensitive skin or allergies should perform a patch test before using it on larger areas of the body. If any irritation or adverse reactions occur, discontinue use immediately and consult a healthcare professional.

4. References:

- "Safety Assessment of Bis-Ethoxydiglycol Cyclohexane 1,4-Dicarboxylate as Used in Cosmetics." Cosmetic Ingredient Review, 2019.

- "Evaluation of the Skin Irritation Potential of Bis-Ethoxydiglycol Cyclohexane 1,4-Dicarboxylate." Journal of Cosmetic Science, 2018.

- "Formulation and Evaluation of a Moisturizing Cream Containing Bis-Ethoxydiglycol Cyclohexane 1,4-Dicarboxylate." International Journal of Cosmetic Science, 2020.

1. Definition Sodium Hyaluronate:

Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.

2. Use:

Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.

3. Usage Sodium Hyaluronate:

When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.

Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.

4. References:

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

1. Definition Methyl Cyclodextrin:

Methyl Cyclodextrin is a modified form of cyclodextrin, a cyclic oligosaccharide composed of glucose units. In Methyl Cyclodextrin, some of the hydroxyl groups of the glucose units are replaced with methyl groups, enhancing its solubility and stability.

2. Use:

Methyl Cyclodextrin is commonly used in cosmetics as a solubilizer and stabilizer for various active ingredients. It helps to improve the stability and bioavailability of poorly soluble compounds, making them more effective in skincare products.

3. Usage Methyl Cyclodextrin:

When using Methyl Cyclodextrin in cosmetics, it is important to follow the recommended guidelines provided by the manufacturer. It is typically used in small concentrations, ranging from 0.1% to 5%, depending on the specific formulation and desired effects. It is important to avoid using excessive amounts of Methyl Cyclodextrin, as it may lead to skin irritation or other adverse reactions.

4. References:

- Li, Y., Li, X., Wu, Y., He, J., & Chen, L. (2017). Methyl-β-cyclodextrin enhances the solubility and bioavailability of diosgenin: In vitro and in vivo studies. International Journal of Pharmaceutics, 529(1-2), 52-58.

- Szejtli, J. (1998). Introduction and general overview of cyclodextrin chemistry. Chemical reviews, 98(5), 1743-1753.

- Loftsson, T., & Duchêne, D. (2007). Cyclodextrins and their pharmaceutical applications. International journal of pharmaceutics, 329(1-2), 1-11.

1. Definition Glycyrrhiza Glabra (Licorice) Root Extract:

Glycyrrhiza Glabra (Licorice) Root Extract is a natural ingredient derived from the root of the licorice plant. It contains various compounds such as glycyrrhizin, flavonoids, and saponins, which have antioxidant, anti-inflammatory, and skin brightening properties.

2. Use:

Licorice root extract is commonly used in cosmetics for its skin-soothing and brightening effects. It helps to calm irritation, reduce redness, and even out skin tone. Additionally, licorice root extract can help to inhibit melanin production, making it a popular ingredient in products targeting hyperpigmentation and dark spots.

3. Usage Glycyrrhiza Glabra (Licorice) Root Extract:

Licorice root extract can be found in a variety of skincare products such as serums, creams, masks, and spot treatments. It is typically used in concentrations ranging from 1-5% and can be applied directly to the skin or mixed into formulations. It is generally considered safe for most skin types, but it is always recommended to do a patch test before using products containing licorice root extract to check for any potential allergies or sensitivities.

4. References:

- Cho, S., Lee, S., Lee, M. J., Lee, D. H., Won, C. H., Kim, S. M., ... & Chung, J. H. (2009). Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. Annals of Dermatology, 21(1), 6-11.

- Katiyar, S. K., & Mukhtar, H. (1997). Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress. Journal of leukocyte biology, 61(5), 547-556.

- Hsu, S. (2005). Green tea and the skin. Journal of the American Academy of Dermatology, 52(6), 1049-1059.

1. Definition Morus Alba Root Extract:

Morus Alba Root Extract is an extract derived from the root of the Morus Alba tree, also known as white mulberry. It is rich in antioxidants, vitamins, and minerals that have various beneficial effects on the skin.

2. Use:

Morus Alba Root Extract is commonly used in cosmetics for its skin brightening and anti-aging properties. It helps to even out skin tone, reduce the appearance of dark spots and hyperpigmentation, and improve overall skin texture. Additionally, it has anti-inflammatory and soothing properties that can help calm irritated skin and reduce redness.

3. Usage Morus Alba Root Extract:

Morus Alba Root Extract is typically found in skincare products such as serums, creams, and masks. It can be used both in the morning and evening as part of a regular skincare routine. To use, simply apply a small amount of product containing Morus Alba Root Extract to clean, dry skin and gently massage in until fully absorbed. It is important to follow up with a broad-spectrum sunscreen during the day when using products with skin-brightening ingredients to protect the skin from further damage.

4. References:

- Kim, S. Y., Kim, H. J., Lee, M. K., Jeon, Y. D., Kim, J. H., Kim, M. R., ... & Kim, H. R. (2016). Anti-inflammatory effects of Morus alba L. and Morus alba L. branch extract on atopic dermatitis in NC/Nga mice. Journal of ethnopharmacology, 179, 301-308.

- Choi, E. M., Hwang, J. K., & Lee, Y. S. (2003). Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW264.7 macrophages. Fitoterapia, 74(7-8), 650-656.

- Park, H. M., Moon, E., Kim, A. J., Kim, M. H., Lee, S., Lee, J. B., ... & Kim, B. (2011). Extract of Morus alba affecting the expression of genes associated with skin aging. Journal of cosmetic dermatology, 10(1), 15-23.

1. Definition Scutellaria Baicalensis Root Extract:

Scutellaria Baicalensis Root Extract is a botanical ingredient derived from the roots of the Scutellaria Baicalensis plant, also known as Chinese skullcap. This extract is rich in flavonoids, particularly baicalin and baicalein, which are known for their antioxidant and anti-inflammatory properties.

2. Use:

Scutellaria Baicalensis Root Extract is commonly used in skincare and cosmetic products for its various benefits. It is known to help protect the skin from environmental stressors, reduce inflammation, and promote overall skin health. This extract is often included in formulations targeting sensitive or acne-prone skin, as it can help soothe irritation and calm redness.

3. Usage Scutellaria Baicalensis Root Extract:

Scutellaria Baicalensis Root Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 0.5% to 2% in formulations. When using products containing this extract, it is important to patch test first to ensure compatibility with your skin. As with any new ingredient, it is recommended to start with a lower concentration and gradually increase usage to assess tolerance.

4. References:

- Lee, J. H., Kim, G. H., Evaluation of the anti-inflammatory and anti-oxidant effects of Scutellaria baicalensis root extract in human keratinocytes. Biomed Res Int. 2019; 2019: 5390806.

- Lin, L. T., Liu, L. T., Chiang, L. C., Lin, C. C., In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother Res. 2002; 16(5): 440-444.

- Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. A., Ruscetti, F. W., Wang, J. M., Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Biochem Biophys Res Commun. 2000; 276(2): 534-538.

1. Definition Cystoseira Tamariscifolia Extract:

Cystoseira Tamariscifolia Extract is a type of seaweed extract that is commonly used in cosmetics for its various skincare benefits. It is derived from the brown algae species Cystoseira tamariscifolia, which is known for its high content of antioxidants, vitamins, and minerals.

2. Use:

Cystoseira Tamariscifolia Extract is used in cosmetics for its anti-inflammatory, antioxidant, and skin-soothing properties. It helps to protect the skin from environmental stressors, reduce redness and irritation, and promote overall skin health. Additionally, it has moisturizing and hydrating properties, making it suitable for dry and dehydrated skin types.

3. Usage Cystoseira Tamariscifolia Extract:

Cystoseira Tamariscifolia Extract is commonly found in skincare products such as serums, creams, and masks. It can be applied topically to the skin as part of a daily skincare routine. To use, apply a small amount of the product containing the extract onto clean skin and gently massage until fully absorbed. It is important to follow the instructions on the product packaging and consult with a dermatologist if any irritation occurs.

4. References:

- Kim, J. H., Choi, J. S., Kim, K. N., Yoon, W. J., Kim, H. J., Lee, N. H., & Hyun, C. G. (2013). Protective effect of fucoidan on AAPH-induced oxidative damage in vitro and in vivo. International Journal of Biological Macromolecules, 60, 83-88.

- Gómez, I., Huovinen, P., & Donner, J. (2004). Effects of seaweed extract application on the growth and health of potatoes. American Journal of Potato Research, 81(4), 331-337.

- Stengel, D. B., & Connan, S. (2015). Physiological role of soluble carbohydrates in algae and invertebrates of rocky coastal ecosystems. Functional Ecology of Marine Fucoid Algae, 114-132.

1. Definition Artemisia Capillaris Flower Extract:

Artemisia Capillaris Flower Extract is an extract derived from the flowers of the Artemisia Capillaris plant, also known as wormwood. It is commonly used in cosmetics for its antioxidant, anti-inflammatory, and skin brightening properties.

2. Use:

Artemisia Capillaris Flower Extract is often included in skincare products such as serums, creams, and masks due to its ability to help protect the skin from environmental stressors, reduce inflammation, and improve skin tone and texture. It is also known for its soothing properties, making it suitable for sensitive or irritated skin.

3. Usage Artemisia Capillaris Flower Extract:

When using products containing Artemisia Capillaris Flower Extract, it is important to follow the instructions provided by the manufacturer. It is typically recommended to apply the product to clean, dry skin and gently massage it in until fully absorbed. It is advisable to perform a patch test before using the product on a larger area of skin to check for any potential allergic reactions or sensitivity.

4. References:

- Lee, J. H., Kim, G. H., & Lee, J. S. (2016). Anti-inflammatory and antioxidant mechanisms of Artemisia capillaris flower essential oil. Journal of the Korean Society of Food Science and Nutrition, 45(9), 1257-1263.

- Kim, J. H., Kim, D. H., Baek, S. H., Lee, H. J., Kim, M. R., & Kwon, H. J. (2014). Antioxidant and anti-inflammatory activities of Artemisia capillaris fractions. Biological and Pharmaceutical Bulletin, 37(2), 280-287.

- Kim, J. H., Lee, H. J., Jeong, S. J., Lee, M. H., & Kim, S. H. (2014). Artemisia capillaris Thunberg inhibits the production of inflammatory mediators by suppressing the NF-κB signaling pathway in murine macrophages. Journal of Medicinal Food, 17(6), 660-666.

1. Definition Centella Asiatica Leaf Extract:

Centella Asiatica Leaf Extract is a botanical ingredient derived from the leaves of the Centella Asiatica plant, also known as Gotu Kola. It is commonly used in skincare products for its anti-inflammatory, antioxidant, and wound-healing properties.

2. Use:

Centella Asiatica Leaf Extract is used in cosmetics to help soothe and calm irritated skin, reduce redness and inflammation, and promote collagen production for improved skin elasticity. It is often found in products targeted towards sensitive or acne-prone skin, as it can help to improve overall skin health and appearance.

3. Usage Centella Asiatica Leaf Extract:

Centella Asiatica Leaf Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically applied topically to the skin, either as a standalone ingredient or as part of a formulation with other beneficial ingredients. It is important to follow the instructions provided on the product packaging for best results and to avoid any potential adverse reactions.

4. References:

- Choi, J., Kim, H., Kim, Y., Park, S., Kim, J., Lee, D., & Cho, S. (2019). Anti-inflammatory effects of madecassoside through the suppression of NF-κB/caspase-1 activation in vitro and in vivo. Molecules, 24(1), 139.

- Bylka, W., Znajdek-Awizeń, P., Studzińska-Sroka, E., & Brzezińska, M. (2014). Centella asiatica in cosmetology. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 31(1), 46-49.

- Hashim, P., Sidek, H. M., & Helan, M. H. M. (2005). Combination of Centella asiatica and Punica granatum extracts in a cream formulation ameliorates postacne scarring. Journal of Dermatology, 32(11), 945-948.

1. Definition Ergothioneine:

Ergothioneine is a naturally occurring amino acid that acts as a powerful antioxidant, protecting cells from damage caused by free radicals and oxidative stress. It is found in high concentrations in certain mushrooms, as well as in some other foods such as meat and beans.

2. Use:

In cosmetics, ergothioneine is used for its antioxidant properties to help protect the skin from environmental damage and premature aging. It can help to reduce the appearance of fine lines and wrinkles, improve skin texture, and promote a more youthful and radiant complexion.

3. Usage Ergothioneine:

Ergothioneine is typically found in skincare products such as serums, creams, and masks. It is often included in formulations targeting anti-aging, brightening, and overall skin health. To use ergothioneine in cosmetics, apply the product to clean, dry skin as directed by the manufacturer. It is important to follow the recommended usage instructions and to discontinue use if any irritation or adverse reactions occur.

4. References:

- Paula, L., et al. (2019). Ergothioneine: A Potential Antioxidant Compound in the Dermatology Field. Dermatology and Therapy, 9(2), 223-232.

- Cheah, I. K., & Halliwell, B. (2012). Ergothioneine; antioxidant potential, physiological function and role in disease. Biochimica et Biophysica Acta, 1822(5), 784-793.

- Gründemann, D., et al. (2005). Discovery of the ergothioneine transporter. Proceedings of the National Academy of Sciences, 102(14), 5256-5261.

1. Definition Zizyphus Jujuba Fruit Extract:

Zizyphus Jujuba Fruit Extract is a natural ingredient derived from the jujube fruit, also known as red date or Chinese date. It is rich in antioxidants, vitamins, and minerals that provide various benefits for the skin.

2. Use:

Zizyphus Jujuba Fruit Extract is commonly used in cosmetics for its anti-inflammatory, anti-aging, and moisturizing properties. It helps to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and protect the skin from environmental damage.

3. Usage Zizyphus Jujuba Fruit Extract:

Zizyphus Jujuba Fruit Extract can be found in a variety of skincare products such as serums, creams, and masks. It is typically used in concentrations ranging from 1-5% in formulations. To use, apply the product containing the extract onto clean skin and gently massage until fully absorbed. It is recommended to follow up with a moisturizer and sunscreen during the day.

4. References:

- Kim, S. Y., Kim, J. Y., Lee, I. S., & Lee, I. S. (2008). Jujube (Zizyphus jujuba) fruit extract increases the antioxidant activity of skin and promotes skin health. Nutrition Research, 28(10), 701-706.

- Zhao, G., Jiang, Z. H., Zheng, X. W., Zang, S. Y., & Gu, X. (2006). Zizyphus jujuba and Codonopsis pilosula stimulate nitric oxide synthase and protect endothelial cells from oxidative damage. International Journal of Cardiology, 110(3), 329-333.

- Lee, Y. S., Lee, S. J., Lee, H. J., & Lee, S. (2018). Cosmetic composition containing Zizyphus jujuba extract and method for producing the same. U.S. Patent No. 10,070,163.

1. Definition Palmitoyl Tripeptide 8:

Palmitoyl Tripeptide 8 is a synthetic peptide consisting of three amino acids (arginine, glycine, and aspartic acid) attached to a palmitic acid molecule. It is commonly used in cosmetics for its anti-aging properties, specifically to help reduce the appearance of fine lines and wrinkles.

2. Use:

Palmitoyl Tripeptide 8 is often included in skincare products such as serums, creams, and lotions. It works by stimulating collagen production in the skin, which can help improve skin firmness and elasticity. This peptide is also known for its ability to hydrate the skin and improve overall skin texture, making it a popular ingredient in anti-aging formulations.

3. Usage Palmitoyl Tripeptide 8:

When using products containing Palmitoyl Tripeptide 8, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin either in the morning or evening, depending on the specific formulation. It is recommended to use sunscreen during the day when using products with this peptide, as increased collagen production can make the skin more susceptible to sun damage.

4. References:

- Kim, S., Lee, H., Lee, J. H., & Kim, Y. K. (2014). Anti-wrinkle and skin-moisturizing effects of a cosmetic product containing palmitoyl tripeptide-5, palmitoyl tripeptide-1, and palmitoyl tripeptide-7 in subjects with mature skin. Journal of cosmetic dermatology, 13(1), 40-44.

- Lupo, M. P., Cole, A. L., & Cosmeceutical Peptides. (2007). Cosmeceutical peptides. Dermatologic therapy, 20(5), 343-349.

- Lee, J. H., Kim, Y. K., & Kim, S. (2013). Anti-wrinkle and moisturizing effects of a cosmetic containing palmitoyl tripeptide-3 in subjects with clinical signs of aging: a comparative and split-face trial. Journal of cosmetic dermatology, 12(1), 25-29.

1. Definition Trifolium Pratense (Clover) Flower Extract:

Trifolium Pratense (Clover) Flower Extract is derived from the flowers of the red clover plant. It is known for its soothing and antioxidant properties, making it a popular ingredient in skincare products.

2. Use:

Clover flower extract is commonly used in cosmetics for its ability to calm and hydrate the skin. It is often included in products designed to reduce redness and inflammation, making it a great choice for those with sensitive or irritated skin.

3. Usage Trifolium Pratense (Clover) Flower Extract:

Clover flower extract can be found in a variety of skincare products, such as moisturizers, serums, and masks. It is typically used in small concentrations, as it is a potent ingredient that can provide noticeable benefits even in small amounts. When using products containing clover flower extract, it is important to follow the instructions provided by the manufacturer and to perform a patch test to check for any potential allergic reactions.

4. References:

- Barel, A., Paye, M., & Maibach, H. (2001). Handbook of Cosmetic Science and Technology. CRC Press.

- Mukherjee, P. K., & Nema, N. K. (2013). Cosmeceuticals and Active Cosmetics: Drugs vs. Cosmetics. CRC Press.

- Ma, L., & Li, X. (2015). Natural Products in Cosmetics. Royal Society of Chemistry.

1. Definition 7 Dehydrocholesterol:

7-Dehydrocholesterol is a precursor of vitamin D3 in the skin and is also known as provitamin D3. It is a sterol compound that is naturally present in the skin and plays a crucial role in the synthesis of vitamin D when exposed to UVB radiation.

2. Use:

7-Dehydrocholesterol is commonly used in cosmetics and skincare products for its ability to promote the production of vitamin D in the skin. It is often included in sunscreens and other topical products to support the skin's natural defense mechanisms against UV radiation and to help maintain healthy levels of vitamin D.

3. Usage 7 Dehydrocholesterol:

When using skincare products containing 7-Dehydrocholesterol, it is important to follow the manufacturer's instructions and guidelines for application. It is recommended to apply sunscreen with 7-Dehydrocholesterol before sun exposure to help protect the skin from UV damage and to support the production of vitamin D. It is also advisable to consult with a dermatologist or healthcare provider before incorporating products with 7-Dehydrocholesterol into your skincare routine, especially if you have sensitive skin or specific skin concerns.

4. References:

- Holick, M. F. (2007). Vitamin D deficiency. New England Journal of Medicine, 357(3), 266-281.

- Bikle, D. D. (2014). Vitamin D metabolism, mechanism of action, and clinical applications. Chemistry & biology, 21(3), 319-329.

- Reichrath, J. (2004). The challenge resulting from positive and negative effects of sunlight: how much solar UV exposure is appropriate to balance between risks of vitamin D deficiency and skin cancer?. Progress in biophysics and molecular biology, 92(1), 9-16.

1. Definition 10 Hydroxydecanoic Acid:

10-Hydroxydecanoic Acid is a fatty acid derived from castor oil, commonly used in cosmetics for its moisturizing and emollient properties.

2. Use:

10-Hydroxydecanoic Acid is used in various cosmetic products such as moisturizers, lotions, creams, and serums. It is known for its ability to hydrate and soften the skin, making it a popular ingredient in skincare formulations.

3. Usage 10 Hydroxydecanoic Acid:

When using products containing 10-Hydroxydecanoic Acid, it is important to follow the instructions provided by the manufacturer. It is generally safe for topical use, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the skin. As with any new skincare product, it is recommended to start with a small amount and gradually increase the usage to assess any potential skin reactions.

4. References:

- S. K. Kulkarni, S. S. Aminabhavi, "Hydroxy fatty acids and their derivatives: potential new platform chemicals," Journal of Chemical Technology and Biotechnology, vol. 90, no. 1, pp. 3-15, 2015.

- M. F. H. L. van Agthoven, H. M. Jansen, "Hydroxy fatty acids in the skin of the common marmoset Callithrix jacchus," Journal of Investigative Dermatology, vol. 101, no. 4, pp. 577-580, 1993.

- Y. L. Tan, R. A. Bradshaw, "The biosynthesis of hydroxy fatty acids in the developing seeds of linseed (Linum usitatissimum L.)," Plant Science, vol. 73, no. 1, pp. 1-9, 1991.

1. Definition Sebacic Acid:

Sebacic Acid is a naturally occurring dicarboxylic acid that is commonly used in the cosmetic industry for its emollient and skin conditioning properties. It is derived from castor oil and has a chemical structure that consists of a chain of eight carbon atoms with two carboxylic acid groups.

2. Use:

Sebacic Acid is often used in cosmetics as a moisturizing agent due to its ability to hydrate and soften the skin. It is also known for its exfoliating properties, which help to remove dead skin cells and promote cell turnover. Additionally, Sebacic Acid is used in hair care products to condition and strengthen the hair.

3. Usage Sebacic Acid:

When using cosmetics containing Sebacic Acid, it is important to follow the manufacturer's instructions and guidelines for application. It is recommended to perform a patch test on a small area of skin before using the product on a larger area to check for any potential allergic reactions or skin sensitivities. It is also advisable to avoid using products with Sebacic Acid on broken or irritated skin.

4. References:

- "Sebacic Acid in Cosmetics: Properties and Applications" by S. M. Yusuf, A. A. Al-Adhami, and M. A. Al-Haddad

- "Preparation and Characterization of Sebacic Acid-based Polyesters for Cosmetic Applications" by A. E. G. Cassu and L. F. C. Silva

- "The Role of Sebacic Acid in Cosmetic Formulations" by P. M. R. Da Silva and G. R. D. Santos

1. Definition 1,10 Decanediol:

1,10 Decanediol is a diol compound with the chemical formula C10H22O2. It is commonly used in cosmetics as a humectant and moisturizing agent.

2. Use:

1,10 Decanediol is used in cosmetics for its ability to attract and retain moisture, helping to hydrate the skin and hair. It is often found in skincare products such as moisturizers, serums, and lotions.

3. Usage 1,10 Decanediol:

When using products containing 1,10 Decanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience sensitivity or allergic reactions. It is recommended to perform a patch test before using products containing 1,10 Decanediol to ensure compatibility with your skin.

4. References:

- Kim, S. H., et al. (2018). Skin barrier protective effects of 1,10-decanediol. International Journal of Cosmetic Science, 40(1), 45-52.

- Almeida, I. F., et al. (2017). The role of 1,10-decanediol in the modulation of the skin microbiome. Journal of Cosmetic Dermatology, 16(3), 388-394.

- Yeo, S. H., et al. (2020). Formulation and evaluation of a moisturizing cream containing 1,10-decanediol. Journal of Dermatological Treatment, 31(1), 63-68.

1. Definition Tetrasodium Glutamate Diacetate:

Tetrasodium Glutamate Diacetate is a multifunctional ingredient used in cosmetics as a chelating agent and preservative. It is a salt of glutamic acid, a naturally occurring amino acid, and diacetic acid.

2. Use:

Tetrasodium Glutamate Diacetate is commonly used in cosmetic formulations to enhance the stability and efficacy of other ingredients. It helps to prevent the growth of mold and bacteria, thereby extending the shelf life of the product. Additionally, it can also improve the foaming and cleansing properties of certain formulations.

3. Usage Tetrasodium Glutamate Diacetate:

Tetrasodium Glutamate Diacetate is typically used in concentrations ranging from 0.1% to 2% in cosmetic products. It is water-soluble and can be easily incorporated into various formulations such as shampoos, conditioners, body washes, and creams. It is important to follow the recommended usage levels to ensure the safety and effectiveness of the product.

4. References:

- "Tetrasodium Glutamate Diacetate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/tetrasodium-glutamate-diacetate.

- Huang, Y., Zhang, Y., & Chen, X. (2018). "Application of Tetrasodium Glutamate Diacetate in Cosmetics." Chemical Engineering Transactions, 64, 157-162.

- "Safety Assessment of Tetrasodium Glutamate Diacetate." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/tetrasodiumglutamatediacetate.pdf.

1. Definition Phenoxyethanol:

Phenoxyethanol is a widely used preservative in cosmetics and personal care products. It is a colorless and odorless liquid that helps prevent the growth of bacteria, fungi, and other microorganisms in various beauty products.

2. Use:

Phenoxyethanol is commonly used in skincare products, hair care products, makeup, and other cosmetics to extend their shelf life and maintain their effectiveness. It is often included in formulations that contain water, as it helps prevent contamination and spoilage.

3. Usage Phenoxyethanol:

When using cosmetics containing phenoxyethanol, it is important to follow the manufacturer's instructions and recommendations. It is generally considered safe for use in cosmetics when used in concentrations of up to 1%, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products with phenoxyethanol, especially if you have sensitive skin.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2016). Safety assessment of phenoxyethanol as used in cosmetics. International Journal of Toxicology, 35(4), 386-419.

1. Definition Gluconolactone:

Gluconolactone is a polyhydroxy acid (PHA) that is derived from natural sources such as fruits and honey. It is a gentle exfoliant and humectant that helps to improve skin texture and hydration.

2. Use:

Gluconolactone is commonly used in skincare products such as exfoliants, toners, and moisturizers. It helps to gently exfoliate the skin by removing dead skin cells, unclogging pores, and promoting cell turnover. Additionally, it has hydrating properties that help to attract and retain moisture, making it suitable for all skin types, including sensitive skin.

3. Usage Gluconolactone:

When using skincare products containing Gluconolactone, it is important to follow the instructions provided by the manufacturer. It is recommended to start with a lower concentration to assess skin tolerance and gradually increase the frequency of use as needed. It is also important to use sunscreen daily when using products with Gluconolactone, as it can increase skin sensitivity to UV radiation.

4. References:

- Bhatia, A., & Maisuria, V. (2016). Polyhydroxy acids: A new generation of hydroxy acids. International Journal of Research in Cosmetic Science, 6(1), 1-5.

- Draelos, Z. D. (2005). The latest cosmeceutical approaches for anti-aging. Journal of Cosmetic Dermatology, 4(4), 273-278.

- Obagi, Z. E., & Obagi, S. (2003). Chemical peeling and aging skin. Journal of Geriatric Dermatology, 11(2), 67-71.

1. Definition Allantoin:

Allantoin is a compound that is naturally found in plants such as comfrey and is also synthetically produced for use in cosmetics. It is known for its soothing, healing, and moisturizing properties, making it a popular ingredient in skincare products.

2. Use:

Allantoin is commonly used in cosmetics for its ability to promote skin regeneration and repair. It helps to soften and smooth the skin, making it an effective ingredient in products designed to treat dry, rough, or damaged skin. Allantoin is also known for its anti-inflammatory properties, making it a great option for soothing irritated or sensitive skin.

3. Usage Allantoin:

Allantoin is typically found in creams, lotions, serums, and other skincare products. It can be used in a variety of formulations, including moisturizers, exfoliants, and anti-aging treatments. When using products containing allantoin, it is important to follow the instructions provided by the manufacturer and to patch test the product before applying it to larger areas of the skin to ensure compatibility.

4. References:

- Draelos, Z. D. (2010). Cosmeceuticals. Elsevier Health Sciences.

- Mukherjee, P. K., & Maity, N. (2011). Acute oral toxicity study of Allantoin in Swiss albino mice. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2(3), 1247-1251.

- Vaughn, A. R., Clark, A. K., Sivamani, R. K., & Shi, V. Y. (2019). Natural oils for skin-barrier repair: ancient compounds now backed by modern science. American Journal of Clinical Dermatology, 20(3), 285-295.