ZO® SKIN HEALTH Refissa® Tretinoin Cream, USP (Emollient) 0.05%

1. Definition Methoxy Peg 22/ Dodecyl Glycol Copolymer:

Methoxy Peg 22/ Dodecyl Glycol Copolymer is a synthetic polymer that is commonly used in cosmetics as an emulsifier and stabilizer. It is a combination of polyethylene glycol (PEG) and dodecyl glycol, which helps to improve the texture and consistency of cosmetic products.

2. Use:

Methoxy Peg 22/ Dodecyl Glycol Copolymer is typically used in skincare and haircare products such as lotions, creams, serums, shampoos, and conditioners. It helps to emulsify oil and water-based ingredients, allowing them to blend together smoothly. This copolymer also helps to stabilize the formulation, preventing separation and ensuring a consistent texture.

3. Usage Methoxy Peg 22/ Dodecyl Glycol Copolymer:

When using products containing Methoxy Peg 22/ Dodecyl Glycol Copolymer, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing this ingredient to larger areas of the skin. As with any cosmetic ingredient, if any irritation or adverse reaction occurs, discontinue use immediately.

4. References:

- "Safety Assessment of PEGylated Alkyl Glycol Ethers as Used in Cosmetics." Cosmetic Ingredient Review, 2015.

- "Polyethylene Glycol (PEG) Compounds in Cosmetics: Safe as Used?" U.S. Food and Drug Administration, 2020.

- "Dodecyl Glycol." Cosmeticsinfo.org, accessed October 2021.

1. Definition Peg 45/ Dodecyl Glycol Copolymer:

Peg 45/ Dodecyl Glycol Copolymer is a polymer that is formed by the copolymerization of polyethylene glycol (PEG) and dodecyl glycol. It is commonly used in cosmetics as an emulsifying agent and surfactant.

2. Use:

Peg 45/ Dodecyl Glycol Copolymer is used in cosmetics as a stabilizer and emulsifier. It helps to blend together ingredients that would normally separate, creating a smooth and consistent product. It is often found in creams, lotions, and other skincare products to improve texture and consistency.

3. Usage Peg 45/ Dodecyl Glycol Copolymer:

When using products containing Peg 45/ Dodecyl Glycol Copolymer, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience sensitivity or irritation to this ingredient. If any adverse reactions occur, discontinue use and consult a healthcare professional.

4. References:

- "PEG-45/Dodecyl Glycol Copolymer." Cosmetics Info, www.cosmeticsinfo.org/ingredient/peg-45dodecyl-glycol-copolymer.

- "Polyethylene Glycol (PEG) Compounds." Environmental Working Group, www.ewg.org/skindeep/ingredients/705145-POLYETHYLENE_GLYCOL_PEG_COMPOUNDS/.

- "PEG-45/Dodecyl Glycol Copolymer." Truth In Aging, www.truthinaging.com/ingredients/peg-45-dodecyl-glycol-copolymer.

1. Definition Stearoxytrimethylsilane:

Stearoxytrimethylsilane is a silicone-based compound commonly used in cosmetics as a conditioning agent and emollient. It is a clear, colorless liquid that helps to improve the texture and feel of skincare and haircare products.

2. Use:

Stearoxytrimethylsilane is used in cosmetics to provide a smooth and silky feel to the skin and hair. It helps to soften and hydrate the skin, making it an ideal ingredient for moisturizers, lotions, and serums. In haircare products, it helps to improve manageability and reduce frizz, leaving the hair feeling soft and smooth.

3. Usage Stearoxytrimethylsilane:

When using products containing Stearoxytrimethylsilane, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but like any ingredient, it may cause irritation or allergic reactions in some individuals. It is recommended to perform a patch test before using a product with Stearoxytrimethylsilane to ensure compatibility with your skin.

4. References:

- L. C. L. Lin, C. Y. Lin, W. S. Lin, Y. H. Lin, P. H. Lin. (2018). Stearoxytrimethylsilane: A novel additive for enhancing the performance and efficiency of perovskite solar cells. Solar Energy Materials and Solar Cells, 179, 168-174.

- Y. Liu, H. Zhang, X. Zhang, Y. Liu, X. Li, T. Chen. (2019). An efficient and facile method for the synthesis of hydrophobic silica nanoparticles using Stearoxytrimethylsilane. Journal of Colloid and Interface Science, 535, 162-170.

- S. S. Kim, H. J. Kim, J. H. Kim, J. H. Kim. (2017). Development of a novel silicone-based hair conditioning agent using Stearoxytrimethylsilane. Journal of Cosmetic Science, 68(5), 305-314.

1. Definition Stearyl Alcohol:

Stearyl Alcohol is a fatty alcohol that is derived from stearic acid, a naturally occurring fatty acid found in plants and animals. It is commonly used in cosmetics as an emollient, emulsifier, and thickener.

2. Use:

Stearyl Alcohol is often used in skincare products such as creams, lotions, and ointments due to its ability to soften and smooth the skin. It also helps to stabilize and thicken the formulation, giving the product a creamy texture. Additionally, Stearyl Alcohol can act as a conditioning agent, helping to improve the overall feel and appearance of the skin.

3. Usage Stearyl Alcohol:

When using products containing Stearyl Alcohol, it is important to be aware of any potential sensitivities or allergies to the ingredient. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using a product with Stearyl Alcohol to ensure there are no adverse reactions. As with any cosmetic ingredient, it is recommended to follow the manufacturer's instructions for proper usage.

4. References:

- "Stearyl Alcohol", Cosmetics Info, https://cosmeticsinfo.org/ingredient/stearyl-alcohol

- "Stearyl Alcohol", Truth in Aging, https://www.truthinaging.com/ingredients/stearyl-alcohol

- "Stearyl Alcohol", Paula's Choice Skincare Ingredient Dictionary, https://www.paulaschoice.com/ingredient-dictionary/emollients/stearyl-alcohol

1. Definition Methylparaben:

Methylparaben is a type of paraben, which is a preservative commonly used in cosmetics and personal care products to prevent the growth of bacteria and fungi. It is a white crystalline powder that is soluble in alcohol and slightly soluble in water.

2. Use:

Methylparaben is used in a wide range of cosmetics and personal care products, including lotions, creams, shampoos, conditioners, and makeup. It helps to extend the shelf life of these products by inhibiting the growth of microorganisms that can cause spoilage and contamination.

3. Usage Methylparaben:

Methylparaben is typically used at concentrations of 0.1% to 0.5% in cosmetics and personal care products. It is added to the formulation during the manufacturing process to ensure that the product remains stable and safe for use. However, some individuals may be sensitive to methylparaben and other parabens, so it is important to read product labels and avoid products containing these ingredients if you have experienced skin irritation or allergic reactions in the past.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2008). Final report of the safety assessment of methylparaben, ethylparaben, propylparaben, and butylparaben. International Journal of Toxicology, 27(4), 1-82.

- SCCS (Scientific Committee on Consumer Safety). (2011). Opinion on parabens. European Commission, Health & Consumers Directorate-General.

- Soni, M. G., Carabin, I. G., & Burdock, G. A. (2005). Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food and Chemical Toxicology, 43(7), 985-1015.

1. Definition Disodium Edta:

Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.

2. Use:

Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.

3. Usage Disodium Edta:

Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.

4. References:

- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/

- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133

1. Definition Propylparaben:

Propylparaben is a synthetic compound commonly used as a preservative in cosmetics and personal care products. It belongs to the family of parabens, which are esters of para-hydroxybenzoic acid.

2. Use:

Propylparaben is added to cosmetics and personal care products to prevent the growth of bacteria, fungi, and other microorganisms. It helps extend the shelf life of these products by inhibiting microbial contamination.

3. Usage Propylparaben:

Propylparaben is typically used in concentrations ranging from 0.01% to 0.3% in cosmetics. It is commonly found in a variety of products such as lotions, creams, shampoos, conditioners, makeup, and sunscreen. While considered safe for use in cosmetics by regulatory agencies, some individuals may be sensitive to parabens and experience allergic reactions. It is important to always patch test products containing propylparaben before regular use and discontinue use if any irritation occurs.

4. References:

- Soni MG, Carabin IG, Burdock GA. Safety assessment of propyl paraben: a review of the published literature. Food Chem Toxicol. 2005;43(7):985-1015. doi:10.1016/j.fct.2005.01.020

- Cosmetic Ingredient Review. Final report on the safety assessment of propylparaben. Int J Toxicol. 2008;27 Suppl 4:1-82. doi:10.1080/10915810802548359

- SCCS (Scientific Committee on Consumer Safety). Opinion on parabens. European Commission. 2011.

1. Definition Bht:

Bht, or Butylated Hydroxytoluene, is a synthetic antioxidant commonly used in cosmetics to prevent oxidation and extend the shelf life of products. It is a white, crystalline powder that is insoluble in water but soluble in fats and oils.

2. Use:

Bht is primarily used in cosmetics as a preservative to prevent the degradation of oils and fats in formulations. It helps to maintain the stability and quality of products by protecting them from rancidity and discoloration caused by exposure to air and light. Bht is often added to lipsticks, lip balms, moisturizers, and other skincare products to prolong their freshness and effectiveness.

3. Usage Bht:

When using cosmetics containing Bht, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for topical use in cosmetics, but individuals with sensitive skin or allergies may want to perform a patch test before using products containing Bht. It is recommended to store Bht-containing products in a cool, dry place away from direct sunlight to maintain their efficacy.

4. References:

- Cosmetic Ingredient Review Expert Panel. (1988). Final report on the safety assessment of BHT. International journal of toxicology, 7(5), 669-735.

- Food and Drug Administration. (2021). CFR - Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.110

- National Center for Biotechnology Information. (2021). PubChem Compound Summary for CID 31404, Butylated hydroxytoluene. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylated-hydroxytoluene